Hub : Genes

R3hdm4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb mRNA stability R3hdm4 0.49 0.19 3.9e-11 0.42 0.35 0.37 0.39 3.9e-11 4.2e-09 8.8e-10 2.7e-10
2 Liver mRNA stability R3hdm4 0.18 0.11 0.0e+00 0.15 0.13 0.14 0.14 5.0e-16 1.4e-14 8.6e-15 4.3e-15
3 NAcc mRNA stability R3hdm4 0.32 0.14 0.0e+00 0.3 0.29 0.3 0.3 2.3e-35 3.6e-34 1.2e-34 1.5e-34
4 BLA mRNA stability R3hdm4 0.27 0.13 1.1e-12 0.23 0.22 0.21 0.22 2.5e-12 6.2e-12 2.2e-11 5.8e-12
5 Adipose mRNA stability R3hdm4 0.27 0.14 0.0e+00 0.21 0.21 0.21 0.21 1.4e-22 9.0e-23 1.3e-22 1.4e-22
6 OFC mRNA stability R3hdm4 0.65 0.17 6.0e-14 0.45 0.45 0.46 0.46 3.5e-12 3.8e-12 1.7e-12 2.0e-12
7 Brain mRNA stability R3hdm4 0.64 0.13 0.0e+00 0.43 0.42 0.42 0.42 5.8e-43 6.7e-42 3.9e-42 5.0e-42
8 PL mRNA stability R3hdm4 0.69 0.17 0.0e+00 0.39 0.39 0.4 0.4 8.4e-46 4.9e-46 9.1e-47 7.5e-47
9 IL mRNA stability R3hdm4 0.6 0.18 8.7e-11 0.22 0.19 0.19 0.21 4.9e-06 2.4e-05 2.7e-05 1.1e-05
10 OFC gene expression R3hdm4 0.68 0.16 0.0e+00 0.55 0.53 0.55 0.55 2.1e-15 7.0e-15 1.2e-15 1.6e-15
11 IL gene expression R3hdm4 0.75 0.14 0.0e+00 0.42 0.4 0.41 0.41 3.2e-11 9.8e-11 6.0e-11 4.5e-11
12 LHb gene expression R3hdm4 0.4 0.18 3.9e-07 0.23 0.17 0.18 0.2 3.9e-06 6.0e-05 4.0e-05 1.7e-05
13 BLA gene expression R3hdm4 0.83 0.08 0.0e+00 0.58 0.62 0.62 0.64 1.5e-37 1.6e-41 3.7e-42 2.1e-43
14 NAcc gene expression R3hdm4 0.59 0.19 0.0e+00 0.53 0.54 0.54 0.54 7.1e-73 4.7e-75 5.4e-75 7.4e-74
15 Brain gene expression R3hdm4 0.81 0.07 0.0e+00 0.58 0.62 0.63 0.63 5.0e-65 6.5e-74 2.1e-75 6.5e-76
16 pVTA gene expression R3hdm4 0.37 0.17 3.6e-13 0.26 0.3 0.29 0.3 1.0e-11 3.0e-13 4.5e-13 2.5e-13
17 Liver gene expression R3hdm4 0.09 0.06 1.3e-07 0.06 0.06 0.06 0.06 5.2e-07 1.9e-07 1.0e-07 1.5e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bone: apparent density0.71.23.4-0.9-0.9-0.8-1.00.7-1.1-0.91.0-1.0-0.7-0.6-0.61.01.51.31.5-1.9
Area under the delay curve2.32.52.91.71.71.71.5-1.61.61.6-1.61.6-1.6-1.6-1.61.61.51.51.4-1.3
BMI with tail6.220.023.84.74.74.74.9-4.84.74.7-4.74.7-4.5-4.5-4.54.34.03.93.7-3.4
BMI without tail2.75.59.42.72.72.62.6-2.73.02.9-3.13.1-2.0-2.1-2.11.81.31.41.3-0.7
Body weight1.25.06.22.32.32.32.4-2.42.42.4-2.52.5-2.2-2.3-2.32.11.82.01.9-1.5
Weight adjusted by age0.80.91.81.31.31.21.3-1.21.31.2-1.21.2-0.4-0.4-0.40.20.1-0.0-0.20.2
Bone surface1.42.54.4-1.8-1.9-1.8-2.01.7-2.1-1.92.0-2.0-0.3-0.2-0.20.81.41.21.5-1.9
Bone volume1.42.34.0-1.7-1.7-1.7-1.91.5-2.0-1.71.9-1.9-0.4-0.3-0.30.91.51.21.6-2.0
Breakpoint value in progressive ratio session5.05.57.0-2.1-2.1-2.1-2.12.2-2.0-2.12.1-2.12.72.72.7-2.7-2.5-2.6-2.52.4
Number of licking bursts0.40.40.70.90.80.90.9-0.70.80.8-0.70.70.00.00.0-0.3-0.4-0.4-0.70.7
Context. condit. distance diff. score0.20.20.70.30.30.30.3-0.50.70.7-0.80.8-0.5-0.6-0.60.40.00.40.30.2
Locomotion velocity, session 10.80.91.8-1.2-1.2-1.2-1.21.2-1.3-1.31.2-1.20.50.50.5-0.20.0-0.00.1-0.3
Locomotion distance, session 11.31.73.8-1.9-1.9-1.9-1.81.6-1.6-1.41.4-1.4-0.2-0.1-0.10.50.50.91.2-0.9
Locomotion velocity, session 25.36.211.5-3.4-3.4-3.4-3.33.1-3.1-3.03.0-3.01.71.71.7-1.4-1.3-0.9-0.60.7
Locomotion distance, session 22.63.67.3-2.5-2.5-2.5-2.42.4-2.7-2.52.6-2.60.91.01.0-0.5-0.1-0.00.3-0.6
Locomotion velocity, session 36.27.38.9-2.7-2.7-2.7-2.52.6-2.4-2.52.5-2.52.92.92.9-2.8-3.0-2.7-2.72.8
Locomotion distance, session 30.00.00.2-0.0-0.10.00.2-0.10.20.2-0.30.30.1-0.0-0.0-0.1-0.4-0.1-0.10.5
Stereotopy head waving bouts, day 35.56.59.0-3.0-3.0-3.0-2.82.9-2.8-2.82.8-2.82.42.32.3-2.1-2.3-1.8-1.81.8
Stereotopy head waving duration, day 36.27.48.8-2.9-2.9-3.0-2.93.0-2.9-2.92.9-2.92.72.72.7-2.5-2.6-2.2-2.32.2
Locomotion velocity, session 70.60.71.8-1.0-1.0-1.0-0.80.7-0.4-0.40.4-0.30.70.70.7-0.8-1.2-0.8-0.81.3
Locomotion distance, session 70.40.51.10.70.70.70.8-0.91.11.0-1.01.0-0.2-0.2-0.2-0.0-0.3-0.2-0.30.6
Stereotopy head waving bouts, day 70.30.40.8-0.9-0.9-0.9-0.70.7-0.7-0.70.6-0.6-0.1-0.1-0.10.30.20.50.6-0.5
Stereotopy head waving duration, day 70.60.71.5-1.2-1.2-1.2-1.01.1-1.1-1.11.0-1.00.20.20.20.00.10.30.4-0.4
Locomotion velocity, session 81.41.74.1-2.0-2.0-2.0-1.71.7-1.7-1.61.6-1.60.40.40.4-0.1-0.30.30.4-0.2
Locomotion distance, session 80.40.61.6-1.3-1.3-1.2-1.21.0-0.9-0.90.8-0.80.30.20.2-0.1-0.20.20.30.0
Degree of sensitization distance0.30.30.50.50.50.50.4-0.60.70.7-0.60.6-0.7-0.7-0.70.60.50.60.5-0.4
Degree of sensitization stereotypy1.61.73.10.90.90.91.0-1.00.91.0-1.01.0-1.5-1.6-1.61.71.61.71.8-1.7
Conditioned locomotion1.72.03.81.71.71.71.9-1.81.91.9-1.91.9-1.0-1.0-1.00.80.50.50.4-0.1
Cocaine response after cond. corrected6.57.311.73.43.43.43.3-3.33.43.4-3.43.4-2.1-2.1-2.11.71.51.31.0-0.9
Cocaine response after cond. not corrected6.77.411.93.43.43.43.3-3.33.53.4-3.43.4-2.1-2.2-2.21.71.51.31.1-0.8
Cocaine response before conditioning0.60.71.2-1.1-1.1-1.1-0.90.9-0.8-0.90.8-0.80.70.70.7-0.6-0.8-0.6-0.50.7
Saline control response0.00.10.20.30.30.30.5-0.30.30.3-0.30.3-0.2-0.2-0.20.20.10.10.2-0.1
Bone: connectivity density0.50.82.9-0.3-0.4-0.3-0.50.2-0.5-0.40.4-0.4-0.9-0.9-0.91.21.51.31.5-1.7
Bone: cortical apparent density0.91.22.21.51.51.51.2-1.21.01.0-0.80.8-1.0-0.9-0.90.91.20.80.6-1.1
Bone: cortical area0.60.81.80.40.40.30.4-0.60.40.5-0.50.5-1.2-1.2-1.21.31.21.31.3-1.2
Bone: cortical porosity0.60.61.2-1.1-1.1-1.1-1.01.0-1.1-1.01.0-1.00.50.40.4-0.3-0.3-0.10.0-0.0
Bone: cortical porosity0.40.40.8-0.9-0.9-0.8-0.70.7-0.8-0.70.7-0.7-0.2-0.3-0.30.50.50.70.9-0.7
Bone: cortical thickness1.01.72.61.01.01.01.1-1.11.01.1-1.01.0-1.6-1.5-1.51.61.61.61.6-1.5
Bone: cortical thickness0.30.40.60.80.80.80.7-0.70.80.7-0.60.60.20.20.2-0.4-0.4-0.6-0.70.6
Bone: cortical tissue density0.60.81.81.31.31.31.1-1.00.80.8-0.70.7-0.8-0.7-0.70.71.00.60.4-0.9
Condit. Reinf. active minus inactive responses4.55.15.9-2.4-2.4-2.4-2.42.4-2.2-2.32.2-2.22.32.32.3-2.2-2.3-2.0-1.92.0
Condit. Reinf. active-inactive response ratio1.92.13.4-1.0-1.0-1.0-1.11.2-1.1-1.21.1-1.11.81.71.7-1.8-1.7-1.8-1.81.7
Condit. Reinf. active responses4.45.48.6-2.9-2.9-2.9-2.82.7-2.7-2.62.7-2.62.02.02.0-1.8-1.7-1.4-1.21.2
Condit. Reinf. inactive responses1.72.04.4-2.1-2.0-2.1-1.81.8-1.9-1.71.8-1.80.70.70.7-0.4-0.2-0.10.2-0.2
Incentive salience index mean2.93.55.9-2.4-2.4-2.4-2.32.2-2.1-2.12.1-2.01.61.51.5-1.3-1.4-1.1-0.91.0
Condit. Reinf. lever presses0.91.22.1-1.4-1.4-1.4-1.21.1-1.3-1.11.1-1.1-0.3-0.3-0.30.70.81.01.3-1.2
Condit. Reinf. active minus inactive responses1.72.14.3-0.8-0.8-0.8-0.70.9-0.9-0.91.1-1.11.81.91.9-1.9-1.9-2.0-2.11.8
Condit. Reinf. active-inactive response ratio0.40.40.80.80.80.80.8-0.60.50.4-0.30.30.50.50.5-0.6-0.4-0.8-0.90.5
Condit. Reinf. active responses1.62.23.6-1.0-1.0-1.0-0.91.1-1.1-1.11.3-1.31.81.81.8-1.8-1.8-1.9-1.91.7
Condit. Reinf. inactive responses1.01.21.9-1.0-1.0-1.0-1.01.0-0.9-0.91.0-1.01.11.21.2-1.1-1.4-1.1-1.21.3
Condit. Reinf. lever presses1.82.54.1-1.2-1.2-1.2-1.11.2-1.1-1.21.2-1.21.91.91.9-2.0-1.9-2.0-1.91.9
Condit. Reinf. lever reinforcers received1.21.73.5-0.7-0.6-0.6-0.50.8-0.7-0.80.9-0.91.61.61.6-1.7-1.7-1.8-1.91.7
Conditioned reinforcement - actives1.91.92.7-1.6-1.6-1.6-1.51.4-1.3-1.41.4-1.41.41.41.4-1.4-1.2-1.3-1.11.1
Conditioned reinforcement - inactives0.50.51.10.80.80.80.8-0.91.01.1-1.11.1-0.5-0.5-0.50.30.30.20.2-0.0
Conditioned locomotion6.47.79.0-3.0-3.0-3.0-2.92.9-2.7-2.82.8-2.82.92.92.9-2.8-2.6-2.6-2.42.3
Patch foraging indifference point 0 sec0.20.30.60.30.30.30.4-0.30.30.3-0.30.3-0.6-0.6-0.60.70.70.70.7-0.6
Patch foraging indifference point AUC0.60.70.9-0.8-0.7-0.7-0.80.8-0.8-0.80.9-0.90.90.90.9-0.9-0.8-0.9-0.80.7
Delay disc. indifference point, 0s delay6.47.013.11.71.71.71.7-1.81.51.7-1.71.7-3.2-3.2-3.23.43.53.53.6-3.6
Delay disc. indifference point, 16s delay0.10.10.30.60.50.60.4-0.40.30.3-0.30.3-0.3-0.3-0.30.20.40.20.1-0.3
Delay disc. indifference point, 2s delay5.15.77.62.12.12.12.0-2.22.02.1-2.12.1-2.7-2.7-2.72.82.62.72.7-2.5
Delay disc. indifference point, 24s delay1.01.01.71.31.31.31.2-1.11.11.1-1.11.1-0.8-0.8-0.80.80.80.60.5-0.6
Delay disc. indifference point, 4s delay0.80.81.20.80.80.80.7-0.80.70.8-0.80.8-1.0-1.0-1.01.11.11.01.0-1.0
Delay disc. indifference point, 8s delay1.71.72.71.61.61.61.4-1.51.61.6-1.61.6-1.1-1.1-1.11.00.80.80.7-0.5
Indifference point function ln k0.30.40.70.80.80.80.8-0.80.80.8-0.80.8-0.5-0.5-0.50.40.30.30.3-0.1
Indifference point function log k0.30.40.70.80.80.80.8-0.80.80.8-0.80.8-0.5-0.5-0.50.40.30.30.3-0.1
Patch foraging total patch changes 0 sec0.10.20.30.30.30.30.4-0.30.30.4-0.30.3-0.4-0.5-0.50.50.50.50.6-0.4
Patch foraging total patch changes 12 sec0.40.50.90.80.80.80.8-0.90.90.9-0.90.9-0.5-0.6-0.60.40.40.30.3-0.2
Patch foraging total patch changes 18 sec1.01.21.4-1.2-1.1-1.1-1.11.2-1.1-1.11.2-1.21.21.11.1-1.1-1.1-1.0-0.90.9
Patch foraging total patch changes 24 sec0.00.10.2-0.2-0.2-0.2-0.30.3-0.4-0.40.4-0.40.20.20.2-0.1-0.0-0.1-0.0-0.1
Patch foraging total patch changes 6 sec0.20.20.5-0.5-0.4-0.4-0.40.5-0.7-0.70.7-0.70.50.40.4-0.4-0.2-0.3-0.30.1
Patch foraging time to switch 0 sec1.11.74.7-0.1-0.1-0.1-0.1-0.20.00.2-0.30.3-1.6-1.6-1.61.81.92.12.2-2.0
Patch foraging water rate 0 sec0.61.02.01.11.11.11.3-1.01.31.1-1.11.10.40.30.3-0.7-1.0-1.0-1.11.4
Patch foraging water rate 12 sec1.92.95.72.42.42.42.3-2.22.32.2-2.22.2-0.9-0.9-0.90.50.30.1-0.10.1
Patch foraging water rate 18 sec1.52.04.01.41.41.41.4-1.21.51.3-1.31.30.80.80.8-1.3-1.5-1.7-1.92.0
Patch foraging water rate 24 sec1.82.44.82.02.12.02.1-1.92.22.0-2.02.0-0.0-0.0-0.0-0.4-0.7-0.9-1.01.3
Patch foraging water rate 6 sec0.71.02.70.70.70.70.6-0.50.70.6-0.50.50.90.90.9-1.2-1.4-1.5-1.61.6
Seeking ratio, delayed vs. immediate footshock4.04.65.8-2.2-2.2-2.2-2.42.3-2.4-2.42.4-2.42.12.12.1-1.9-1.8-1.8-1.71.5
Distance traveled before self-admin0.50.61.20.60.70.50.5-0.50.40.5-0.50.5-0.9-0.9-0.91.01.01.00.9-1.1
Distance traveled after self-admin0.50.60.9-0.9-0.8-0.9-0.90.9-0.9-0.90.9-0.90.60.60.6-0.5-0.5-0.4-0.50.3
Extensor digitorum longus weight4.417.424.14.54.54.54.7-4.74.94.9-4.94.9-4.1-4.1-4.13.63.03.22.9-2.2
Bone: elastic displacement0.10.20.4-0.2-0.2-0.2-0.30.4-0.5-0.30.6-0.60.50.50.5-0.4-0.1-0.4-0.3-0.1
Bone: elastic work0.30.40.70.70.70.70.5-0.60.50.7-0.50.4-0.7-0.7-0.70.70.80.70.7-0.8
Bone: endosteal estimation0.10.30.50.40.40.30.4-0.40.40.6-0.40.4-0.7-0.7-0.70.70.40.70.5-0.5
Bone: endosteal perimeter0.30.61.4-1.1-1.1-1.2-1.11.0-0.9-1.00.9-0.90.50.50.5-0.4-0.4-0.2-0.20.3
Epididymis fat weight0.30.60.9-0.7-0.7-0.7-0.70.7-0.6-0.60.6-0.60.90.90.9-1.0-0.9-1.0-0.90.9
Delta time in closed arm before/after self-admin1.91.83.71.81.91.91.7-1.71.91.8-1.81.8-0.4-0.4-0.40.1-0.1-0.3-0.50.7
Delta time in open arm before/after self-admin1.11.01.70.90.80.80.8-0.80.70.8-0.80.8-1.2-1.2-1.21.21.31.21.1-1.3
Diff in mean of infusions in LGA sessions2.02.22.4-1.5-1.5-1.5-1.51.5-1.5-1.51.5-1.51.61.61.6-1.5-1.4-1.4-1.41.2
Delay discount exponential model param2.22.32.8-1.7-1.6-1.7-1.51.6-1.6-1.61.6-1.61.61.61.6-1.5-1.4-1.4-1.21.2
Extinction: sum of active levers before priming1.11.11.9-0.7-0.8-0.8-0.80.8-0.6-0.60.7-0.71.21.21.2-1.3-1.3-1.4-1.31.4
Active lever presses in extinction session 62.22.12.9-1.5-1.5-1.6-1.71.6-1.6-1.61.6-1.61.51.51.5-1.4-1.1-1.2-1.10.8
Bone: final force1.32.03.11.11.11.01.1-1.21.11.4-1.21.2-1.7-1.7-1.71.81.51.81.7-1.4
Bone: final moment1.01.62.51.01.01.01.0-1.11.01.2-1.01.0-1.5-1.5-1.51.61.31.61.5-1.3
Food consumed during 24 hour testing period0.80.92.01.41.41.41.0-1.11.11.1-1.11.1-0.8-0.8-0.80.70.60.60.3-0.4
Glucose1.62.43.41.81.81.81.9-1.71.51.5-1.61.6-1.4-1.5-1.51.41.41.31.2-1.2
Heart weight0.20.30.90.00.00.0-0.00.1-0.1-0.30.1-0.10.80.70.7-0.8-0.7-1.0-0.90.7
Delay discount hyperbolic model param3.03.23.5-1.9-1.8-1.9-1.71.8-1.8-1.81.8-1.81.91.91.9-1.8-1.7-1.7-1.61.5
Intermittent access intake day 1-15 change5.95.86.9-2.3-2.4-2.3-2.32.4-2.1-2.22.2-2.22.62.62.6-2.6-2.6-2.5-2.42.5
Intermittent access intake escalation5.45.38.2-1.9-1.9-1.9-1.91.9-1.6-1.71.7-1.72.72.72.7-2.8-2.8-2.8-2.72.9
Intermittent access intake escalation 26.56.49.3-2.1-2.2-2.1-2.12.1-1.8-2.02.0-2.03.02.92.9-3.0-3.0-3.1-3.03.0
Intermitt. access day 1 inactive lever presses0.20.20.70.10.20.10.1-0.10.30.3-0.30.30.50.50.5-0.6-0.6-0.7-0.80.9
Intermitt. access day 15 inactive lever presses0.50.50.9-0.6-0.6-0.6-0.60.6-0.4-0.50.5-0.50.80.80.8-0.9-0.9-0.9-0.90.9
Intermitt. access escalation Index0.30.31.00.00.00.10.0-0.0-0.2-0.10.1-0.1-0.6-0.6-0.60.80.80.90.9-1.0
Intermittent access day 1 total infusions0.00.00.20.10.10.10.0-0.10.20.2-0.20.2-0.2-0.2-0.20.20.40.20.3-0.3
Intermittent access day 15 total infusions1.71.92.9-1.1-1.2-1.1-1.21.2-1.0-1.01.0-1.01.61.61.6-1.7-1.6-1.7-1.61.7
Intermittent access terminal intake (last 3 days)0.90.91.2-1.0-1.1-1.0-1.11.0-0.8-0.80.8-0.81.11.11.1-1.1-1.0-1.1-0.91.1
Intermittent access total infusions0.20.20.4-0.3-0.4-0.3-0.40.3-0.2-0.20.2-0.20.50.50.5-0.6-0.5-0.6-0.50.6
Intermittent access day 1 locomotion0.40.40.6-0.5-0.6-0.5-0.60.6-0.5-0.50.5-0.50.80.80.8-0.8-0.7-0.8-0.80.7
Intermittent access day 15 total locomotion3.43.74.3-1.9-1.9-1.9-2.01.9-1.8-1.81.8-1.82.12.12.1-2.0-1.9-2.0-1.91.8
Intermittent access total locomotion0.91.01.3-1.1-1.1-1.1-1.21.1-1.0-1.01.0-1.01.01.01.0-1.0-0.9-0.9-0.80.8
Intermittent access standard deviation2.32.43.7-1.3-1.3-1.3-1.21.3-1.1-1.21.2-1.21.81.81.8-1.9-1.9-1.9-1.91.9
Left kidney weight0.00.10.3-0.3-0.3-0.3-0.50.4-0.5-0.60.5-0.5-0.0-0.1-0.10.20.10.30.2-0.4
Right kidney weight1.13.24.2-1.8-1.8-1.8-2.11.9-1.9-1.91.9-1.91.81.81.8-1.7-1.7-1.5-1.71.4
Cocaine induced anxiety0.80.91.8-1.2-1.3-1.2-1.31.2-1.4-1.31.3-1.30.40.40.4-0.2-0.00.10.2-0.3
Post-drug Anxiety0.80.91.8-1.3-1.3-1.3-1.31.2-1.3-1.31.3-1.30.50.50.5-0.2-0.10.00.1-0.3
Baseline Anxiety0.30.31.0-0.00.0-0.00.00.00.10.0-0.00.00.60.60.6-0.8-0.9-0.9-1.01.0
Tail length2.78.110.2-2.8-2.8-2.8-2.92.8-2.4-2.62.4-2.43.12.92.9-3.0-3.2-2.9-2.83.1
Length with tail1.66.07.9-2.7-2.7-2.8-2.82.7-2.6-2.72.6-2.62.42.32.3-2.2-2.2-2.0-1.81.9
Length without tail0.20.51.0-1.0-0.9-1.0-0.80.8-1.0-0.91.0-1.00.00.10.10.10.20.30.4-0.6
Times rat made contact with spout0.50.51.31.11.11.10.9-0.90.90.9-0.90.9-0.3-0.3-0.30.1-0.0-0.0-0.40.3
Lifetime Intake0.10.10.1-0.2-0.3-0.3-0.30.2-0.1-0.10.1-0.10.30.30.3-0.3-0.3-0.4-0.30.4
Liver weight, left2.03.24.01.91.91.91.9-1.92.01.9-2.02.0-1.8-1.8-1.81.71.61.51.5-1.3
Liver weight, right1.32.13.01.21.21.21.1-1.31.31.4-1.41.4-1.7-1.7-1.71.71.51.71.6-1.4
Locomotor activity3.04.87.9-2.7-2.6-2.7-2.82.6-2.7-2.52.7-2.71.81.81.8-1.5-1.3-1.2-1.00.9
Locomotor testing distance1.72.84.4-2.0-2.0-2.0-2.12.0-2.0-1.92.0-2.01.51.51.5-1.3-1.1-1.1-0.90.8
Locomotor testing rearing0.10.10.30.30.30.30.3-0.30.40.3-0.30.30.30.30.3-0.4-0.5-0.5-0.50.6
Locomotion in novel chamber0.10.20.70.20.10.1-0.00.1-0.1-0.10.3-0.30.50.50.5-0.5-0.6-0.6-0.90.6
Locomotion in novel chamber post-restriction0.91.02.3-0.8-0.8-0.8-0.70.8-0.6-0.70.7-0.71.11.11.1-1.2-1.4-1.2-1.31.5
Fecal boli incidents, locomotor time 11.71.92.51.41.41.41.4-1.41.51.6-1.61.6-1.4-1.4-1.41.31.11.21.1-0.9
Change in fecal boli incidents, locomotor task0.10.10.2-0.4-0.4-0.4-0.30.4-0.4-0.40.4-0.40.20.20.2-0.1-0.3-0.0-0.00.2
Time >=10cm from walls, locomotor time 10.90.92.40.50.50.40.4-0.40.30.4-0.40.4-1.2-1.2-1.21.31.51.41.4-1.5
Bouts of movement, locomotor time 10.20.20.9-0.3-0.3-0.3-0.40.4-0.2-0.20.2-0.20.40.40.4-0.5-0.8-0.5-0.60.9
Total resting periods, locomotor time 10.30.30.7-0.5-0.5-0.5-0.60.5-0.4-0.40.4-0.40.50.50.5-0.6-0.8-0.5-0.60.9
Rest time, locomotor task time 10.50.51.0-1.0-1.0-1.0-1.00.9-0.7-0.70.7-0.70.50.50.5-0.4-0.8-0.3-0.30.8
Distance moved, locomotor task time 10.80.92.90.60.60.60.5-0.50.30.3-0.30.3-1.1-1.1-1.11.21.61.31.3-1.7
Vertical activity count, locomotor time 10.60.71.51.21.21.21.2-1.00.90.9-0.90.9-0.3-0.3-0.30.20.50.0-0.1-0.4
Time >=10cm from walls, locomotor time 22.02.12.81.61.61.61.6-1.61.71.7-1.71.7-1.4-1.4-1.41.21.11.10.9-0.8
Bouts of movement, locomotor time 20.80.91.9-1.1-1.2-1.1-1.31.2-1.4-1.31.3-1.30.50.50.5-0.3-0.1-0.1-0.0-0.2
Total resting periods, locomotor time 20.80.91.8-1.1-1.2-1.1-1.31.2-1.3-1.31.3-1.30.50.50.5-0.2-0.0-0.00.0-0.2
Rest time, locomotor task time 20.60.71.5-1.0-1.0-1.0-1.21.1-1.1-1.11.1-1.10.60.60.6-0.5-0.4-0.3-0.40.3
Distance moved, locomotor task time 20.70.81.20.91.00.91.0-1.11.11.1-1.11.1-0.8-0.8-0.80.70.70.60.6-0.5
Vertical activity count, locomotor time 21.01.12.31.21.31.21.4-1.41.51.5-1.51.5-0.7-0.7-0.70.50.30.30.2-0.1
Light reinforcement 16.111.114.9-3.7-3.7-3.7-3.83.7-3.7-3.93.7-3.73.23.23.2-2.9-2.6-2.6-2.32.0
Light reinforcement 22.33.14.4-2.0-2.1-2.0-1.91.9-2.0-2.12.0-2.01.71.71.7-1.5-1.1-1.3-1.10.9
Bone: marrow area0.10.30.50.40.40.30.4-0.40.40.6-0.40.5-0.7-0.7-0.70.70.40.70.5-0.4
Bone: maximum diameter0.81.52.9-1.6-1.6-1.7-1.61.5-1.6-1.61.5-1.50.80.80.8-0.6-0.6-0.4-0.30.3
Bone: maximum force1.22.13.01.21.31.21.3-1.41.31.6-1.41.4-1.7-1.7-1.71.71.41.61.5-1.2
Bone: maximum moment1.01.72.41.21.21.11.2-1.31.21.4-1.21.2-1.5-1.5-1.51.51.31.51.3-1.2
Mean time between licks in bursts3.85.36.5-2.2-2.2-2.2-2.02.2-2.1-2.22.2-2.22.52.52.5-2.5-2.5-2.4-2.42.3
Mean num. licks in bursts0.00.00.10.10.10.1-0.10.0-0.0-0.1-0.00.0-0.2-0.2-0.20.20.30.20.3-0.3
Cd content in liver0.30.30.50.50.50.50.7-0.50.40.4-0.30.3-0.6-0.5-0.50.60.70.60.7-0.7
Co content in liver0.50.60.8-0.9-0.9-0.9-0.70.7-0.6-0.70.7-0.70.80.80.8-0.8-0.9-0.8-0.70.9
Cu content in liver0.20.30.8-0.3-0.3-0.3-0.30.2-0.2-0.10.2-0.2-0.6-0.5-0.50.70.80.80.9-0.9
Fe content in liver0.10.20.8-0.6-0.6-0.6-0.10.20.10.0-0.10.10.30.20.2-0.4-0.8-0.4-0.30.9
K content in liver0.50.51.2-1.1-1.1-1.1-0.60.6-0.7-0.60.6-0.6-0.4-0.3-0.30.60.30.70.9-0.4
Mg content in liver0.40.40.8-0.9-0.9-0.9-0.50.5-0.6-0.60.6-0.6-0.4-0.4-0.40.60.50.80.9-0.7
Mn content in liver2.12.35.5-2.3-2.3-2.3-2.11.9-2.0-1.81.9-1.90.40.50.5-0.1-0.20.20.4-0.2
Na content in liver0.80.92.7-0.4-0.4-0.40.1-0.20.20.4-0.30.3-1.3-1.2-1.21.41.11.51.6-1.2
Rb content in liver0.50.61.8-0.1-0.1-0.1-0.0-0.0-0.1-0.0-0.00.0-1.0-1.0-1.01.11.11.31.3-1.3
Se content in liver0.40.51.1-1.1-1.1-1.1-1.00.8-0.6-0.60.6-0.60.40.50.5-0.4-0.7-0.3-0.20.7
Sr content in liver0.20.20.50.40.40.40.4-0.40.50.4-0.40.40.30.20.2-0.4-0.5-0.5-0.60.7
Zn content in liver1.81.95.0-0.3-0.3-0.3-0.40.5-0.4-0.60.5-0.51.81.81.8-2.0-1.9-2.2-2.22.1
Bone: minimum diameter0.00.10.2-0.4-0.4-0.5-0.20.2-0.1-0.10.1-0.1-0.3-0.2-0.20.30.00.40.3-0.1
Time in familiar zone, hab. session 12.12.03.2-1.0-1.0-1.0-1.31.1-1.0-1.11.1-1.11.61.71.7-1.8-1.6-1.8-1.81.7
Time in novel zone, hab. session 11.21.12.50.60.60.60.7-0.60.50.6-0.60.6-1.2-1.3-1.31.51.41.51.6-1.5
Total zone transitions, hab. session 11.52.14.0-2.0-2.0-2.0-1.91.9-2.0-1.91.9-1.90.80.80.8-0.5-0.4-0.10.1-0.1
Total locomotion distance, hab. session 12.13.06.6-2.6-2.6-2.5-2.42.3-2.3-2.12.2-2.20.70.70.7-0.3-0.30.10.4-0.2
Locomotion velocity, hab. session 12.63.77.7-2.8-2.8-2.7-2.62.5-2.5-2.32.4-2.41.01.01.0-0.7-0.7-0.20.00.1
Time in familiar zone, hab. session 25.55.78.6-1.6-1.7-1.7-2.12.1-1.9-2.12.0-2.02.92.82.8-2.9-2.8-2.9-2.92.7
Time in novel zone, hab. session 24.54.56.31.81.91.81.8-1.81.61.8-1.71.7-2.5-2.4-2.42.52.42.52.3-2.4
Total zone transitions, hab. session 20.91.23.3-0.8-0.8-0.8-0.90.9-1.2-0.91.0-1.0-0.8-0.7-0.71.21.31.51.6-1.8
Total locomotion distance, hab. session 21.72.34.7-1.9-1.9-1.8-2.12.0-2.2-2.02.0-2.00.80.80.8-0.5-0.2-0.1-0.0-0.2
Locomotion velocity, hab. session 21.92.65.6-2.0-2.0-2.0-2.32.2-2.4-2.22.2-2.20.70.70.7-0.3-0.00.10.2-0.5
Novel to familiar place preference ratio4.14.27.41.41.41.41.6-1.51.31.5-1.51.5-2.4-2.4-2.42.62.62.72.7-2.6
Novelty place preference2.62.65.01.01.01.01.1-1.10.91.0-1.11.1-1.9-1.9-1.92.12.12.22.2-2.2
Time in novel zone, NPP test2.82.95.11.21.21.21.2-1.31.11.2-1.31.3-2.0-2.0-2.02.12.12.22.3-2.1
Total zone transitions, NPP test0.50.71.5-0.9-0.9-0.9-0.90.9-1.1-1.01.0-1.0-0.3-0.2-0.20.60.80.91.0-1.2
Total locomotion distance, NPP test0.50.71.4-1.1-1.1-1.0-0.90.9-1.0-0.80.8-0.8-0.4-0.4-0.40.70.71.01.2-1.1
Locomotion velocity, NPP test0.60.91.6-1.2-1.2-1.2-1.11.1-1.3-1.11.1-1.1-0.1-0.1-0.10.40.50.70.9-0.9
Intraocular pressure0.50.71.31.11.11.10.9-0.80.90.7-0.70.70.50.50.5-0.8-0.6-1.0-1.10.9
Delta distance traveled before/after self-admin1.71.92.5-1.5-1.6-1.5-1.41.4-1.3-1.41.3-1.31.41.41.4-1.3-1.4-1.2-1.11.2
Delta ambulatory time before/after self-admin1.92.13.0-1.7-1.7-1.6-1.61.6-1.5-1.51.5-1.51.41.41.4-1.3-1.4-1.2-1.11.2
Parametrial fat weight0.30.51.1-0.5-0.5-0.5-0.70.6-0.4-0.50.4-0.40.90.70.7-0.9-1.0-0.8-0.81.0
Pavlov. Cond. lever latency0.40.51.41.21.11.11.0-0.80.70.5-0.50.50.30.30.3-0.5-0.2-0.7-0.90.4
Pavlov. Cond. magazine entry latency3.54.55.9-2.4-2.4-2.4-2.32.2-1.9-2.01.9-1.92.12.12.1-2.1-2.3-1.9-1.82.1
Pavlov. Cond. change in total contacts0.30.30.9-1.0-0.9-0.9-0.80.6-0.4-0.40.4-0.40.20.20.2-0.2-0.5-0.1-0.10.5
Pavlov. Cond. index score1.01.23.2-1.8-1.7-1.7-1.61.4-1.2-1.11.1-1.10.60.60.6-0.5-0.8-0.3-0.10.6
Pavlov. Cond. latency score1.11.43.9-2.0-1.9-1.9-1.71.5-1.4-1.31.2-1.20.50.50.5-0.3-0.6-0.00.10.4
Pavlov. Cond. lever contacts0.60.72.0-1.4-1.4-1.3-1.21.0-1.0-0.80.8-0.8-0.2-0.1-0.10.30.20.60.8-0.4
Pavlov. Cond. magazine entry number1.11.42.41.61.51.51.4-1.31.11.2-1.01.0-1.0-1.0-1.01.01.20.90.8-1.1
Pavlov. Cond. intertrial magazine entries0.20.31.00.30.30.30.2-0.20.20.1-0.00.00.60.60.6-0.7-0.6-0.9-1.00.7
Pavlov. Cond. lever-magazine prob. diff.1.41.73.8-1.9-1.9-1.9-1.81.6-1.4-1.41.3-1.30.90.90.9-0.8-1.0-0.5-0.40.9
Pavlov. Cond. response bias1.61.93.3-1.8-1.8-1.8-1.61.5-1.3-1.31.3-1.31.21.21.2-1.2-1.4-1.0-0.91.3
Pavlov. Cond. lever latency0.40.60.90.70.60.60.5-0.60.50.6-0.60.6-0.9-0.9-0.90.90.90.90.9-0.9
Pavlov. Cond. magazine entry latency0.40.40.6-0.7-0.7-0.7-0.60.6-0.5-0.60.5-0.50.70.60.6-0.6-0.8-0.6-0.60.8
Pavlov. Cond. change in total contacts0.40.61.1-0.4-0.4-0.4-0.30.5-0.5-0.60.6-0.60.91.01.0-1.0-0.9-1.1-1.00.8
Pavlov. Cond. index score0.50.71.1-0.7-0.7-0.6-0.50.6-0.6-0.70.6-0.61.01.01.0-1.0-1.1-1.0-1.01.0
Pavlov. Cond. latency score0.50.60.8-0.7-0.7-0.7-0.60.7-0.6-0.70.7-0.70.90.90.9-0.9-0.9-0.8-0.80.8
Pavlov. Cond. lever contacts0.50.61.3-0.5-0.4-0.4-0.30.4-0.3-0.50.4-0.41.01.01.0-1.1-1.1-1.1-1.11.1
Pavlov. Cond. magazine entry number0.60.71.01.01.01.00.8-0.80.70.8-0.70.7-0.9-0.9-0.90.91.00.80.8-1.0
Pavlov. Cond. intertrial magazine entries0.40.51.11.01.01.01.0-1.01.01.0-0.90.9-0.4-0.4-0.40.30.10.1-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.60.71.0-0.8-0.8-0.8-0.70.7-0.7-0.80.7-0.70.90.90.9-0.9-1.0-0.9-0.90.9
Pavlov. Cond. response bias1.21.72.9-0.9-0.9-0.9-0.80.9-0.8-1.00.9-0.91.61.61.6-1.6-1.7-1.7-1.71.7
Time in closed arm before self-admin0.80.92.60.0-0.1-0.20.1-0.1-0.10.1-0.10.1-1.1-1.1-1.11.31.41.51.5-1.6
Time in closed arm after self-admin0.00.00.1-0.1-0.0-0.00.00.0-0.0-0.00.0-0.00.20.20.2-0.2-0.3-0.2-0.20.3
Time in open arm before self-admin0.60.61.1-0.6-0.6-0.4-0.60.6-0.5-0.60.6-0.60.90.90.9-0.9-1.0-1.0-0.91.1
Time in open arm after self-admin0.80.91.21.11.11.11.0-1.01.01.0-1.01.0-0.9-0.9-0.90.90.90.80.7-0.7
Bone: periosteal estimation0.30.61.50.20.30.20.2-0.40.30.4-0.30.3-1.0-1.0-1.01.11.01.21.1-1.0
Bone: periosteal perimeter0.20.30.7-0.8-0.8-0.9-0.70.6-0.6-0.60.6-0.6-0.1-0.1-0.10.20.20.40.4-0.3
Bone: post-yield work0.50.61.20.70.70.60.9-0.91.11.1-1.01.0-0.8-0.8-0.80.70.20.60.5-0.0
Progressive ratio test 1 active lever presses0.10.20.30.50.50.50.4-0.40.60.5-0.50.5-0.0-0.0-0.0-0.1-0.1-0.2-0.30.4
Progressive ratio test 1 breakpoint0.20.20.40.60.60.60.5-0.50.60.6-0.60.6-0.1-0.1-0.10.0-0.1-0.1-0.10.3
Progressive ratio test 1 inactive lever presses0.00.00.1-0.1-0.2-0.1-0.30.2-0.2-0.20.2-0.20.20.20.2-0.2-0.1-0.2-0.20.2
Progressive ratio test 2 active lever presses0.20.20.60.0-0.00.0-0.00.00.20.1-0.10.10.50.50.5-0.6-0.6-0.7-0.70.8
Progressive ratio test 2 breakpoint0.20.20.4-0.3-0.3-0.3-0.30.3-0.2-0.20.2-0.20.50.50.5-0.6-0.5-0.6-0.60.6
Progressive ratio test 2 inactive lever presses0.10.10.2-0.4-0.4-0.4-0.50.3-0.3-0.20.2-0.20.10.10.1-0.10.1-0.10.10.0
Incentive Sensitization - Responses0.10.10.40.10.00.10.0-0.10.20.2-0.20.20.40.40.4-0.5-0.5-0.6-0.60.6
Incentive Sensitization - Breakpoint0.10.10.4-0.0-0.1-0.0-0.10.10.10.1-0.10.10.50.50.5-0.6-0.5-0.6-0.60.7
Sum of active levers in priming session hrs 5-60.00.00.0-0.1-0.1-0.1-0.20.1-0.1-0.10.1-0.0-0.1-0.1-0.10.10.20.10.2-0.2
Progressive ratio0.10.10.20.20.20.20.3-0.30.40.5-0.40.4-0.3-0.3-0.30.20.10.20.20.0
Food seeking constrained by brief footshock0.50.61.2-1.1-1.1-1.1-1.11.1-1.0-0.90.9-0.90.40.40.4-0.4-0.5-0.2-0.20.5
Seeking ratio, punishment vs. effort0.30.40.7-0.8-0.8-0.8-0.70.8-0.8-0.90.8-0.80.40.40.4-0.3-0.2-0.2-0.10.1
Retroperitoneal fat weight0.20.71.20.91.00.90.9-0.91.01.0-1.11.1-0.8-0.8-0.80.70.50.60.5-0.4
Reaction time number correct1.11.63.21.71.71.71.7-1.61.81.6-1.71.7-0.4-0.4-0.40.1-0.2-0.2-0.50.6
Reaction time mean minus median0.50.61.2-0.6-0.6-0.6-0.50.6-0.5-0.60.5-0.50.91.01.0-1.0-1.1-1.0-1.11.1
Reaction time mean minus median AUC0.10.10.2-0.4-0.3-0.4-0.30.3-0.3-0.30.3-0.3-0.3-0.2-0.20.30.20.50.5-0.4
Reaction time num false alarms0.40.61.40.70.70.81.0-1.01.21.0-1.11.1-0.1-0.1-0.1-0.1-0.3-0.4-0.40.7
Reaction time num false alarms AUC0.60.81.90.90.90.91.2-1.11.41.2-1.31.3-0.1-0.1-0.1-0.1-0.3-0.4-0.50.8
Reaction time trials correct on left1.11.63.21.71.71.71.7-1.61.81.6-1.71.7-0.4-0.4-0.40.1-0.2-0.2-0.50.6
Reaction time trials on left1.11.53.01.71.71.71.7-1.61.71.6-1.61.6-0.5-0.4-0.40.1-0.1-0.2-0.40.5
Reaction time mean0.00.00.20.20.10.10.1-0.1-0.0-0.10.1-0.1-0.2-0.2-0.20.30.30.30.3-0.5
Reaction time mean AUC0.10.10.40.20.20.20.2-0.20.00.00.0-0.0-0.3-0.3-0.30.40.40.40.4-0.6
Median of all reaction times0.30.41.00.50.50.50.5-0.50.30.3-0.30.3-0.7-0.7-0.70.80.90.80.8-1.0
Reaction time omissions0.20.30.8-0.3-0.4-0.4-0.50.6-0.8-0.90.8-0.80.50.50.5-0.4-0.1-0.3-0.4-0.1
Reaction time false alarm rate0.00.00.1-0.1-0.0-0.00.2-0.30.40.3-0.40.4-0.1-0.1-0.10.10.10.00.10.1
Reaction time premature initiation rate0.81.12.0-0.5-0.5-0.5-0.60.7-0.7-0.80.8-0.81.41.31.3-1.4-1.3-1.4-1.41.2
Reaction time premature initiations0.71.13.20.40.40.40.3-0.10.2-0.00.0-0.01.21.21.2-1.5-1.5-1.6-1.81.6
Std. dev. reaction times0.10.10.2-0.3-0.2-0.2-0.10.2-0.3-0.40.3-0.30.40.40.4-0.4-0.5-0.4-0.50.4
Reaction time trials completed1.11.53.01.71.71.71.7-1.61.71.6-1.61.6-0.5-0.4-0.40.1-0.1-0.2-0.40.5
Reaction time trials AUC1.21.73.41.81.81.81.8-1.61.81.7-1.71.7-0.4-0.3-0.3-0.0-0.3-0.3-0.60.7
Run reversals in cocaine runway, females0.40.40.7-0.7-0.7-0.8-0.80.8-0.7-0.60.7-0.70.60.60.6-0.6-0.6-0.5-0.40.5
Run reversals in cocaine runway, males1.71.62.2-1.4-1.4-1.4-1.41.4-1.5-1.51.5-1.51.21.21.2-1.1-1.0-1.0-0.90.8
Latency to leave start box in cocaine runway0.80.92.0-1.2-1.2-1.2-1.11.1-1.4-1.31.4-1.40.50.50.5-0.20.2-0.00.2-0.6
Latency to leave start box in cocaine runway, F0.80.83.4-0.4-0.4-0.4-0.30.4-0.7-0.60.7-0.7-0.7-0.7-0.71.11.51.21.5-1.8
Latency to leave start box in cocaine runway, M2.52.44.2-1.1-1.1-1.1-1.01.1-0.9-1.01.0-1.01.91.91.9-2.0-2.1-2.0-2.12.0
Std. dev. time between licks in bursts0.60.71.0-1.0-1.0-1.0-0.80.9-1.0-1.01.0-1.00.80.80.8-0.7-0.8-0.6-0.60.6
Total sessions with >9 infusions0.10.10.20.0-0.10.0-0.10.0-0.00.0-0.00.0-0.3-0.3-0.30.30.40.40.4-0.4
Short access day 1 total inactive lever presses0.10.10.3-0.4-0.4-0.4-0.50.4-0.4-0.30.3-0.30.30.30.3-0.2-0.1-0.2-0.20.2
Short access day 10 total inactive lever presses0.00.00.00.20.20.20.1-0.10.20.2-0.20.2-0.0-0.0-0.0-0.00.0-0.1-0.10.1
Short access day 1 total infusions0.40.40.9-0.9-0.9-0.9-1.00.8-0.8-0.80.8-0.80.20.20.2-0.10.00.00.2-0.1
Short access day 10 total infusions0.10.10.40.10.00.10.0-0.00.20.2-0.20.20.40.40.4-0.5-0.5-0.6-0.50.7
Short access total infusions0.00.00.0-0.1-0.2-0.1-0.20.1-0.1-0.00.0-0.0-0.1-0.1-0.10.10.10.10.2-0.1
Short access day 1 locomotion1.01.11.9-1.2-1.3-1.2-1.41.3-1.2-1.21.2-1.20.90.90.9-0.8-0.7-0.7-0.50.5
Short access day 10 total locomotion3.33.74.7-1.8-1.8-1.8-1.71.7-1.6-1.71.7-1.72.12.12.1-2.2-2.2-2.1-2.02.0
Short access total locomotion0.70.81.1-1.0-1.0-1.0-1.01.0-0.9-0.90.9-0.90.80.80.8-0.8-0.8-0.7-0.60.7
One hour access (0.3 mA shock)0.10.10.20.30.30.30.4-0.40.50.5-0.50.5-0.3-0.3-0.30.20.30.20.3-0.1
Compulsive drug intake1.31.32.20.80.80.80.9-0.90.70.8-0.80.8-1.4-1.4-1.41.51.41.51.5-1.5
One hour access (shock baseline)0.20.30.90.0-0.00.00.1-0.00.20.2-0.20.20.60.60.6-0.7-0.7-0.9-0.80.9
Social response proportion0.91.02.0-1.2-1.2-1.2-1.11.2-1.4-1.31.4-1.40.70.70.7-0.5-0.4-0.3-0.30.1
Social responses6.38.110.6-3.3-3.2-3.2-3.23.2-3.2-3.03.2-3.22.62.72.7-2.5-2.4-2.2-2.01.9
Social time0.50.71.30.70.60.60.7-0.60.50.6-0.60.6-0.9-1.0-1.01.01.11.01.2-1.1
Soleus weight8.525.027.95.25.25.25.1-5.35.25.2-5.25.2-5.2-5.2-5.24.94.74.54.4-3.9
Bone: stiffness2.64.15.91.61.61.61.8-1.91.92.0-2.12.1-2.4-2.4-2.42.41.92.32.2-1.6
Tibialis anterior weight1.03.64.71.81.71.71.9-2.02.02.0-2.22.2-2.0-2.1-2.11.91.51.81.8-1.2
Time to tail flick, vehicle, before self-admin0.60.71.4-1.0-1.0-1.1-1.11.1-1.2-1.11.0-1.00.40.40.4-0.20.0-0.00.0-0.3
Time to tail flick, vehicle, after self-admin0.30.41.4-0.0-0.10.10.0-0.10.30.2-0.20.20.60.60.6-0.8-0.9-1.0-0.91.2
Time to tail flick, test, before self-admin0.40.40.8-0.7-0.8-0.7-0.90.8-0.9-0.80.9-0.90.20.20.2-0.00.20.20.3-0.4
Time to tail flick, test, after self-admin0.40.40.7-0.8-0.8-0.8-0.70.8-0.8-0.80.8-0.80.50.50.5-0.4-0.4-0.3-0.20.3
Delta time to tail flick, vehicle, before/after SA0.80.81.81.01.01.11.1-1.11.31.3-1.21.2-0.2-0.2-0.2-0.1-0.3-0.4-0.30.8
Delta time to tail flick, test, before/after SA0.30.31.1-0.2-0.1-0.2-0.00.10.0-0.0-0.00.00.60.60.6-0.7-0.9-0.8-0.91.0
Tibia length0.82.22.8-1.3-1.3-1.4-1.41.4-1.3-1.31.4-1.41.61.71.7-1.6-1.6-1.6-1.51.4
Ambulatory time before self-admin0.50.51.10.60.60.60.5-0.60.40.5-0.50.5-0.8-0.8-0.80.90.90.90.8-1.0
Ambulatory time after self-admin0.30.30.5-0.6-0.6-0.7-0.70.7-0.7-0.70.7-0.70.40.40.4-0.4-0.3-0.3-0.30.1
Bone: tissue strength1.71.62.21.11.11.11.1-1.21.01.1-1.01.0-1.5-1.4-1.41.51.51.41.4-1.4
Total heroin consumption1.92.22.7-1.5-1.5-1.5-1.61.6-1.5-1.61.6-1.61.51.51.5-1.5-1.3-1.4-1.21.1
Bone: trabecular number1.01.53.2-1.7-1.7-1.7-1.81.6-1.6-1.61.6-1.60.60.60.6-0.4-0.1-0.10.1-0.2
Bone: trabecular spacing1.62.03.91.91.91.91.9-1.72.01.9-1.81.8-0.2-0.2-0.2-0.3-0.6-0.6-0.91.0
Bone: trabecular thickness1.72.05.6-1.2-1.2-1.2-1.41.1-1.5-1.31.4-1.4-0.9-0.8-0.81.31.91.72.0-2.4
Bone: trabecular tissue density1.52.13.01.61.61.61.6-1.61.61.7-1.61.6-1.4-1.4-1.41.31.01.21.0-0.7
Water consumed over 24 hours0.60.71.20.70.70.70.6-0.60.50.7-0.50.5-1.0-1.0-1.01.11.01.10.9-1.0
Number of responses in last shaping day0.10.10.2-0.4-0.4-0.4-0.40.3-0.2-0.20.2-0.20.40.40.4-0.4-0.2-0.4-0.30.4