Hub : Genes

Qser1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC intron excision ratio chr3_111603227_111604953 0.18 0.16 4.7e-03 0.07 0.06 0.07 0.06 6.4e-04 1.8e-03 4.8e-04 1.1e-03
2 Adipose mRNA stability Qser1 0.02 0.02 7.6e-03 0.01 0.01 0.01 0.01 2.5e-02 1.0e-02 4.3e-02 1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.61.11.21.0-1.1
Area under the delay curve0.10.10.1-0.30.4
BMI with tail0.00.10.10.4-0.1
BMI without tail0.20.60.60.8-0.8
Body weight0.83.33.41.8-1.8
Weight adjusted by age0.20.30.4-0.30.6
Bone surface0.20.40.50.6-0.7
Bone volume0.81.41.41.1-1.2
Breakpoint value in progressive ratio session1.01.21.4-1.21.0
Number of licking bursts0.20.30.40.6-0.5
Context. condit. distance diff. score4.75.75.92.4-2.4
Locomotion velocity, session 11.71.82.0-1.41.3
Locomotion distance, session 10.20.20.2-0.50.5
Locomotion velocity, session 20.00.00.0-0.00.1
Locomotion distance, session 20.00.00.0-0.2-0.0
Locomotion velocity, session 30.00.00.10.3-0.1
Locomotion distance, session 30.10.10.10.3-0.2
Stereotopy head waving bouts, day 30.20.20.3-0.40.6
Stereotopy head waving duration, day 30.10.20.20.4-0.4
Locomotion velocity, session 70.20.20.20.4-0.4
Locomotion distance, session 70.10.10.1-0.30.2
Stereotopy head waving bouts, day 70.10.10.1-0.20.3
Stereotopy head waving duration, day 70.10.10.1-0.20.3
Locomotion velocity, session 80.20.20.30.5-0.5
Locomotion distance, session 82.73.94.31.9-2.1
Degree of sensitization distance0.20.20.3-0.60.3
Degree of sensitization stereotypy0.30.30.3-0.50.6
Conditioned locomotion6.27.17.8-2.52.8
Cocaine response after cond. corrected3.54.34.3-2.02.1
Cocaine response after cond. not corrected1.01.11.2-1.11.1
Cocaine response before conditioning5.97.17.52.6-2.7
Saline control response0.10.10.20.4-0.3
Bone: connectivity density0.60.91.00.9-1.0
Bone: cortical apparent density0.10.10.20.3-0.4
Bone: cortical area0.81.31.31.1-1.1
Bone: cortical porosity0.20.20.2-0.40.5
Bone: cortical porosity0.10.10.1-0.30.3
Bone: cortical thickness0.10.10.20.3-0.4
Bone: cortical thickness1.51.71.8-1.31.4
Bone: cortical tissue density0.10.10.20.3-0.4
Condit. Reinf. active minus inactive responses2.52.72.81.7-1.7
Condit. Reinf. active-inactive response ratio7.07.47.52.7-2.7
Condit. Reinf. active responses0.40.50.50.7-0.7
Condit. Reinf. inactive responses2.12.52.7-1.71.5
Incentive salience index mean1.51.91.91.3-1.4
Condit. Reinf. lever presses0.30.50.50.6-0.7
Condit. Reinf. active minus inactive responses1.82.42.41.5-1.6
Condit. Reinf. active-inactive response ratio4.85.65.72.3-2.4
Condit. Reinf. active responses1.11.51.61.3-1.2
Condit. Reinf. inactive responses0.00.10.1-0.20.3
Condit. Reinf. lever presses1.72.32.31.5-1.5
Condit. Reinf. lever reinforcers received1.21.71.71.3-1.3
Conditioned reinforcement - actives4.27.27.32.7-2.7
Conditioned reinforcement - inactives8.212.012.33.5-3.4
Conditioned locomotion3.54.65.02.2-2.0
Patch foraging indifference point 0 sec0.00.10.1-0.00.4
Patch foraging indifference point AUC0.81.21.2-1.11.1
Delay disc. indifference point, 0s delay0.10.10.10.3-0.4
Delay disc. indifference point, 16s delay0.60.70.7-0.80.8
Delay disc. indifference point, 2s delay0.10.10.20.5-0.2
Delay disc. indifference point, 24s delay0.60.60.6-0.80.8
Delay disc. indifference point, 4s delay0.30.30.3-0.50.6
Delay disc. indifference point, 8s delay0.00.00.00.1-0.1
Indifference point function ln k0.50.91.00.9-1.0
Indifference point function log k0.50.91.00.9-1.0
Patch foraging total patch changes 0 sec0.00.10.1-0.00.3
Patch foraging total patch changes 12 sec0.10.20.30.5-0.3
Patch foraging total patch changes 18 sec0.10.20.3-0.30.5
Patch foraging total patch changes 24 sec0.10.20.4-0.30.6
Patch foraging total patch changes 6 sec0.10.10.2-0.30.4
Patch foraging time to switch 0 sec0.30.60.70.8-0.7
Patch foraging water rate 0 sec0.00.00.0-0.10.1
Patch foraging water rate 12 sec0.00.10.1-0.30.2
Patch foraging water rate 18 sec0.40.50.60.7-0.8
Patch foraging water rate 24 sec0.00.10.10.2-0.3
Patch foraging water rate 6 sec0.10.10.1-0.40.2
Seeking ratio, delayed vs. immediate footshock0.10.20.20.3-0.5
Distance traveled before self-admin0.00.10.10.2-0.2
Distance traveled after self-admin0.50.60.70.8-0.8
Extensor digitorum longus weight0.10.40.5-0.60.7
Bone: elastic displacement0.50.60.6-0.80.7
Bone: elastic work0.00.00.0-0.10.1
Bone: endosteal estimation0.00.10.1-0.20.3
Bone: endosteal perimeter0.30.50.60.8-0.7
Epididymis fat weight1.44.74.92.2-2.1
Delta time in closed arm before/after self-admin0.20.20.2-0.40.5
Delta time in open arm before/after self-admin0.20.20.2-0.40.4
Diff in mean of infusions in LGA sessions0.20.20.2-0.50.4
Delay discount exponential model param0.10.20.20.3-0.5
Extinction: sum of active levers before priming0.10.10.1-0.40.2
Active lever presses in extinction session 60.50.50.60.8-0.7
Bone: final force0.30.60.60.7-0.7
Bone: final moment0.20.40.40.6-0.6
Food consumed during 24 hour testing period3.85.25.72.2-2.4
Glucose2.23.53.91.8-2.0
Heart weight0.30.50.6-0.80.7
Delay discount hyperbolic model param0.20.20.30.4-0.5
Intermittent access intake day 1-15 change1.02.02.21.5-1.3
Intermittent access intake escalation1.22.42.71.6-1.5
Intermittent access intake escalation 21.51.71.81.3-1.3
Intermitt. access day 1 inactive lever presses1.03.63.81.9-2.0
Intermitt. access day 15 inactive lever presses0.81.71.91.2-1.4
Intermitt. access escalation Index0.40.50.6-0.70.8
Intermittent access day 1 total infusions2.43.94.01.9-2.0
Intermittent access day 15 total infusions3.85.65.82.4-2.3
Intermittent access terminal intake (last 3 days)3.04.04.22.0-1.9
Intermittent access total infusions3.54.14.32.0-2.1
Intermittent access day 1 locomotion2.53.13.31.8-1.7
Intermittent access day 15 total locomotion0.50.91.11.0-0.8
Intermittent access total locomotion3.03.53.92.0-1.8
Intermittent access standard deviation1.53.23.41.7-1.8
Left kidney weight1.25.45.42.3-2.3
Right kidney weight1.88.28.32.9-2.8
Cocaine induced anxiety0.20.30.30.5-0.5
Post-drug Anxiety0.20.20.2-0.40.4
Baseline Anxiety2.63.03.0-1.71.7
Tail length0.41.62.01.1-1.4
Length with tail1.45.96.42.3-2.5
Length without tail1.44.44.42.1-2.1
Times rat made contact with spout0.40.40.40.7-0.6
Lifetime Intake3.13.73.91.9-2.0
Liver weight, left3.04.95.12.3-2.2
Liver weight, right1.93.33.41.8-1.8
Locomotor activity0.00.00.1-0.20.2
Locomotor testing distance1.62.93.11.6-1.7
Locomotor testing rearing0.30.60.70.7-0.9
Locomotion in novel chamber0.60.70.80.9-0.8
Locomotion in novel chamber post-restriction0.71.21.3-1.11.0
Fecal boli incidents, locomotor time 14.56.56.9-2.62.5
Change in fecal boli incidents, locomotor task2.42.32.51.6-1.5
Time >=10cm from walls, locomotor time 10.80.91.2-1.10.8
Bouts of movement, locomotor time 10.00.00.1-0.20.0
Total resting periods, locomotor time 10.10.10.2-0.40.2
Rest time, locomotor task time 13.34.14.9-2.21.8
Distance moved, locomotor task time 11.72.52.51.6-1.6
Vertical activity count, locomotor time 10.20.60.60.8-0.7
Time >=10cm from walls, locomotor time 21.92.83.21.6-1.8
Bouts of movement, locomotor time 21.01.61.71.3-1.2
Total resting periods, locomotor time 21.01.71.81.3-1.3
Rest time, locomotor task time 22.83.63.7-1.91.9
Distance moved, locomotor task time 22.93.54.11.7-2.0
Vertical activity count, locomotor time 22.63.53.71.8-1.9
Light reinforcement 10.10.10.10.3-0.4
Light reinforcement 20.40.60.8-0.90.6
Bone: marrow area0.00.10.1-0.20.4
Bone: maximum diameter0.30.50.50.7-0.7
Bone: maximum force0.71.21.41.2-1.0
Bone: maximum moment0.40.70.90.9-0.8
Mean time between licks in bursts0.20.50.6-0.60.8
Mean num. licks in bursts0.00.00.0-0.1-0.0
Cd content in liver2.12.32.61.4-1.6
Co content in liver1.11.31.4-1.21.0
Cu content in liver1.21.41.6-1.21.1
Fe content in liver0.00.00.0-0.10.1
K content in liver0.90.91.0-0.91.0
Mg content in liver0.10.20.2-0.40.4
Mn content in liver1.01.11.3-1.21.0
Na content in liver1.11.21.41.0-1.2
Rb content in liver1.21.41.5-1.21.1
Se content in liver4.45.25.5-2.22.3
Sr content in liver0.00.00.0-0.10.1
Zn content in liver0.00.00.0-0.0-0.1
Bone: minimum diameter1.62.93.11.8-1.7
Time in familiar zone, hab. session 11.11.01.0-1.01.0
Time in novel zone, hab. session 11.91.91.91.4-1.3
Total zone transitions, hab. session 11.72.42.41.6-1.6
Total locomotion distance, hab. session 10.30.50.60.8-0.6
Locomotion velocity, hab. session 10.20.30.40.7-0.4
Time in familiar zone, hab. session 20.20.20.3-0.50.5
Time in novel zone, hab. session 20.20.20.30.4-0.5
Total zone transitions, hab. session 20.50.60.70.7-0.8
Total locomotion distance, hab. session 20.40.50.5-0.70.7
Locomotion velocity, hab. session 20.30.40.4-0.60.7
Novel to familiar place preference ratio3.23.53.81.9-1.8
Novelty place preference3.53.84.12.0-1.9
Time in novel zone, NPP test2.93.13.31.8-1.7
Total zone transitions, NPP test1.72.52.7-1.61.5
Total locomotion distance, NPP test2.33.13.1-1.81.8
Locomotion velocity, NPP test1.92.72.7-1.61.7
Intraocular pressure0.40.60.6-0.80.8
Delta distance traveled before/after self-admin0.00.00.00.2-0.2
Delta ambulatory time before/after self-admin0.30.40.40.6-0.6
Parametrial fat weight0.00.00.00.00.1
Pavlov. Cond. lever latency0.40.60.7-0.60.8
Pavlov. Cond. magazine entry latency1.01.31.51.0-1.2
Pavlov. Cond. change in total contacts0.00.00.0-0.20.1
Pavlov. Cond. index score0.20.30.40.4-0.6
Pavlov. Cond. latency score0.30.40.50.5-0.7
Pavlov. Cond. lever contacts0.50.60.70.6-0.8
Pavlov. Cond. magazine entry number1.31.71.9-1.21.4
Pavlov. Cond. intertrial magazine entries0.10.10.10.4-0.2
Pavlov. Cond. lever-magazine prob. diff.0.10.20.20.3-0.5
Pavlov. Cond. response bias0.91.11.30.9-1.1
Pavlov. Cond. lever latency1.72.32.4-1.51.6
Pavlov. Cond. magazine entry latency1.01.21.21.1-1.1
Pavlov. Cond. change in total contacts0.40.60.70.7-0.8
Pavlov. Cond. index score2.02.72.81.6-1.7
Pavlov. Cond. latency score1.82.32.51.5-1.6
Pavlov. Cond. lever contacts2.53.53.71.8-1.9
Pavlov. Cond. magazine entry number1.21.41.5-1.21.2
Pavlov. Cond. intertrial magazine entries0.00.00.00.00.0
Pavlov. Cond. lever-magazine prob. diff.1.72.32.41.5-1.6
Pavlov. Cond. response bias2.83.83.91.9-2.0
Time in closed arm before self-admin5.77.37.42.7-2.7
Time in closed arm after self-admin3.23.54.02.0-1.7
Time in open arm before self-admin5.86.36.4-2.52.5
Time in open arm after self-admin5.96.56.6-2.52.6
Bone: periosteal estimation0.10.10.10.4-0.3
Bone: periosteal perimeter0.71.31.31.2-1.1
Bone: post-yield work0.00.00.0-0.10.1
Progressive ratio test 1 active lever presses1.82.22.51.4-1.6
Progressive ratio test 1 breakpoint1.72.12.41.3-1.6
Progressive ratio test 1 inactive lever presses2.23.23.31.8-1.8
Progressive ratio test 2 active lever presses6.27.27.42.6-2.7
Progressive ratio test 2 breakpoint6.47.37.52.7-2.7
Progressive ratio test 2 inactive lever presses5.48.78.73.0-2.9
Incentive Sensitization - Responses3.44.85.02.2-2.2
Incentive Sensitization - Breakpoint3.64.74.82.1-2.2
Sum of active levers in priming session hrs 5-62.62.42.7-1.71.4
Progressive ratio0.81.31.41.2-1.1
Food seeking constrained by brief footshock0.10.10.20.3-0.4
Seeking ratio, punishment vs. effort0.40.60.6-0.80.8
Retroperitoneal fat weight20.085.589.69.5-9.0
Reaction time number correct0.20.30.4-0.60.5
Reaction time mean minus median0.00.00.1-0.30.1
Reaction time mean minus median AUC0.00.00.0-0.20.0
Reaction time num false alarms2.12.93.3-1.61.8
Reaction time num false alarms AUC2.64.14.5-1.92.1
Reaction time trials correct on left0.20.30.4-0.60.5
Reaction time trials on left0.20.40.5-0.70.5
Reaction time mean0.20.40.50.5-0.7
Reaction time mean AUC0.40.70.80.7-0.9
Median of all reaction times0.60.81.00.8-1.0
Reaction time omissions0.20.30.4-0.60.6
Reaction time false alarm rate2.23.13.6-1.61.9
Reaction time premature initiation rate0.00.00.00.00.1
Reaction time premature initiations0.10.20.2-0.40.5
Std. dev. reaction times0.00.00.00.1-0.2
Reaction time trials completed0.20.40.5-0.70.5
Reaction time trials AUC0.10.20.3-0.50.4
Run reversals in cocaine runway, females2.52.42.51.6-1.5
Run reversals in cocaine runway, males0.10.10.1-0.20.3
Latency to leave start box in cocaine runway0.70.80.9-0.90.9
Latency to leave start box in cocaine runway, F0.50.60.6-0.80.8
Latency to leave start box in cocaine runway, M0.00.00.1-0.10.2
Std. dev. time between licks in bursts0.30.40.50.7-0.6
Total sessions with >9 infusions1.11.41.51.1-1.2
Short access day 1 total inactive lever presses1.41.81.91.4-1.3
Short access day 10 total inactive lever presses0.30.70.80.8-0.9
Short access day 1 total infusions2.83.74.01.9-2.0
Short access day 10 total infusions1.41.81.91.3-1.4
Short access total infusions1.51.92.21.2-1.5
Short access day 1 locomotion1.21.51.61.3-1.2
Short access day 10 total locomotion1.73.23.21.8-1.8
Short access total locomotion1.72.02.01.4-1.4
One hour access (0.3 mA shock)4.95.75.82.4-2.4
Compulsive drug intake3.23.83.9-1.92.0
One hour access (shock baseline)5.68.58.52.9-2.9
Social response proportion3.64.04.3-2.11.9
Social responses0.30.40.6-0.70.5
Social time5.98.18.7-3.02.7
Soleus weight0.30.91.0-0.91.0
Bone: stiffness1.21.92.11.5-1.3
Tibialis anterior weight1.55.15.4-2.22.3
Time to tail flick, vehicle, before self-admin0.40.40.40.6-0.6
Time to tail flick, vehicle, after self-admin3.34.44.62.2-2.1
Time to tail flick, test, before self-admin1.61.71.81.2-1.3
Time to tail flick, test, after self-admin2.62.72.81.7-1.6
Delta time to tail flick, vehicle, before/after SA1.21.11.21.1-1.0
Delta time to tail flick, test, before/after SA0.10.10.2-0.20.4
Tibia length0.10.40.5-0.70.4
Ambulatory time before self-admin0.00.00.00.1-0.1
Ambulatory time after self-admin0.91.01.11.0-1.0
Bone: tissue strength0.40.40.4-0.70.6
Total heroin consumption0.40.40.5-0.70.6
Bone: trabecular number0.50.80.90.8-0.9
Bone: trabecular spacing0.00.00.10.3-0.1
Bone: trabecular thickness0.40.60.70.7-0.8
Bone: trabecular tissue density0.40.50.6-0.70.7
Water consumed over 24 hours0.91.21.31.0-1.1
Number of responses in last shaping day5.56.16.12.5-2.5