Hub : Genes

Qpctl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL isoform ratio XR_005501477.2 0.08 0.2 2.7e-03 0.03 0.02 0.02 0.03 5.2e-04 3.5e-03 2.5e-03 7.4e-04
2 Adipose alternative polyA XM_063283177.1 0.04 0.04 3.6e-04 0.03 0.03 0.03 0.03 2.7e-04 4.0e-04 2.9e-04 2.2e-04
3 Brain gene expression Qpctl 0.03 0.03 4.6e-03 0.02 0.02 0 0.02 7.6e-03 4.0e-03 2.3e-01 7.5e-03
4 NAcc intron excision ratio chr1_87919724_87921201 0.01 0.01 6.6e-03 0.01 0.01 0 0.01 1.4e-02 1.1e-02 8.0e-02 2.1e-02
5 PL gene expression Qpctl 0.09 0.07 2.4e-10 0.09 0.09 0.09 0.09 1.9e-10 4.9e-10 3.4e-10 4.5e-10
6 Liver gene expression Qpctl 0.08 0.1 3.2e-03 0.01 0.01 0.02 0.01 1.6e-02 4.3e-02 4.5e-03 5.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density0.00.00.00.1-0.1-0.0-0.0-0.1-0.1
Area under the delay curve1.31.51.8-1.01.01.31.41.3-1.3
BMI with tail0.72.54.32.1-2.0-1.5-1.5-1.50.5
BMI without tail1.03.25.92.4-2.4-1.6-1.6-1.50.3
Body weight1.46.310.43.2-3.2-2.4-2.4-2.30.9
Weight adjusted by age0.00.00.00.1-0.1-0.1-0.10.0-0.1
Bone surface0.30.50.80.9-0.9-0.7-0.7-0.60.1
Bone volume0.20.30.40.7-0.7-0.6-0.6-0.60.2
Breakpoint value in progressive ratio session2.02.43.3-1.81.71.71.61.5-0.8
Number of licking bursts2.23.64.51.9-1.9-2.0-2.0-2.11.4
Context. condit. distance diff. score0.10.10.20.1-0.1-0.3-0.3-0.40.4
Locomotion velocity, session 10.10.10.3-0.50.50.30.30.10.3
Locomotion distance, session 10.00.00.1-0.20.2-0.1-0.1-0.00.4
Locomotion velocity, session 21.31.62.11.5-1.4-1.3-1.3-1.30.6
Locomotion distance, session 20.20.30.40.6-0.6-0.6-0.6-0.50.3
Locomotion velocity, session 30.20.30.50.7-0.7-0.5-0.5-0.4-0.0
Locomotion distance, session 30.70.81.1-0.70.80.90.91.0-1.0
Stereotopy head waving bouts, day 30.91.11.41.0-1.1-1.1-1.1-1.20.8
Stereotopy head waving duration, day 30.91.01.50.9-0.9-1.1-1.1-1.20.9
Locomotion velocity, session 70.20.20.3-0.50.50.40.40.5-0.1
Locomotion distance, session 70.00.00.10.3-0.2-0.1-0.10.10.0
Stereotopy head waving bouts, day 70.91.11.60.8-0.9-1.1-1.1-1.31.0
Stereotopy head waving duration, day 70.70.91.30.8-0.9-1.0-1.0-1.10.8
Locomotion velocity, session 80.00.00.0-0.10.10.10.10.10.0
Locomotion distance, session 80.00.00.00.0-0.0-0.1-0.00.00.1
Degree of sensitization distance0.50.50.60.7-0.7-0.8-0.8-0.70.7
Degree of sensitization stereotypy1.01.11.50.9-0.9-1.1-1.1-1.21.0
Conditioned locomotion0.00.10.1-0.30.30.20.20.3-0.1
Cocaine response after cond. corrected0.50.60.70.6-0.6-0.8-0.8-0.80.8
Cocaine response after cond. not corrected1.31.51.71.2-1.2-1.3-1.3-1.31.1
Cocaine response before conditioning1.61.92.31.5-1.5-1.4-1.4-1.41.0
Saline control response1.82.42.81.6-1.6-1.7-1.7-1.70.9
Bone: connectivity density0.00.10.20.1-0.10.10.20.3-0.4
Bone: cortical apparent density0.00.00.1-0.20.20.20.30.3-0.0
Bone: cortical area1.52.32.61.6-1.6-1.6-1.6-1.60.9
Bone: cortical porosity0.10.20.2-0.40.40.40.40.4-0.3
Bone: cortical porosity0.00.00.00.0-0.0-0.0-0.0-0.1-0.1
Bone: cortical thickness0.50.91.10.9-0.9-1.0-1.0-1.00.7
Bone: cortical thickness1.31.51.91.2-1.2-1.3-1.3-1.40.9
Bone: cortical tissue density0.10.10.1-0.30.30.40.40.4-0.1
Condit. Reinf. active minus inactive responses0.60.60.91.0-1.0-0.7-0.7-0.80.4
Condit. Reinf. active-inactive response ratio0.40.50.70.9-0.8-0.6-0.6-0.70.3
Condit. Reinf. active responses0.30.40.60.8-0.8-0.6-0.6-0.60.3
Condit. Reinf. inactive responses0.10.10.2-0.30.30.20.30.4-0.2
Incentive salience index mean0.40.50.91.0-0.9-0.6-0.6-0.70.2
Condit. Reinf. lever presses0.10.20.40.6-0.6-0.2-0.2-0.2-0.2
Condit. Reinf. active minus inactive responses0.10.10.20.1-0.2-0.3-0.3-0.30.4
Condit. Reinf. active-inactive response ratio0.20.20.40.3-0.3-0.6-0.6-0.50.6
Condit. Reinf. active responses0.00.10.1-0.30.30.30.30.2-0.0
Condit. Reinf. inactive responses0.50.60.8-0.80.80.90.90.7-0.5
Condit. Reinf. lever presses0.10.20.30.5-0.5-0.4-0.4-0.40.2
Condit. Reinf. lever reinforcers received0.10.10.2-0.40.40.40.40.3-0.1
Conditioned reinforcement - actives1.42.33.61.9-1.8-1.6-1.5-1.40.5
Conditioned reinforcement - inactives0.81.22.41.6-1.5-0.9-0.9-0.8-0.2
Conditioned locomotion1.82.42.81.4-1.4-1.7-1.7-1.71.4
Patch foraging indifference point 0 sec0.30.50.80.4-0.4-0.8-0.8-0.90.8
Patch foraging indifference point AUC3.34.76.52.5-2.5-2.2-2.2-2.11.2
Delay disc. indifference point, 0s delay0.91.01.3-0.70.71.11.11.1-1.1
Delay disc. indifference point, 16s delay0.80.91.3-0.60.71.01.11.1-1.2
Delay disc. indifference point, 2s delay2.83.13.9-1.31.41.91.92.0-1.9
Delay disc. indifference point, 24s delay0.00.00.1-0.00.0-0.2-0.2-0.20.1
Delay disc. indifference point, 4s delay0.00.00.00.1-0.10.00.00.1-0.0
Delay disc. indifference point, 8s delay1.31.61.9-1.31.31.41.41.3-0.8
Indifference point function ln k1.22.24.0-2.02.01.31.31.2-0.4
Indifference point function log k1.22.24.0-2.02.01.31.31.2-0.4
Patch foraging total patch changes 0 sec0.40.71.10.5-0.6-1.0-1.0-1.10.8
Patch foraging total patch changes 12 sec1.72.23.41.8-1.8-1.4-1.4-1.40.6
Patch foraging total patch changes 18 sec1.72.63.41.4-1.5-1.7-1.7-1.81.4
Patch foraging total patch changes 24 sec0.40.71.11.0-1.0-0.8-0.8-0.80.3
Patch foraging total patch changes 6 sec2.13.33.91.8-1.8-1.9-1.9-2.01.2
Patch foraging time to switch 0 sec2.04.25.1-2.12.12.32.32.1-1.3
Patch foraging water rate 0 sec2.45.06.02.3-2.3-2.5-2.4-2.41.4
Patch foraging water rate 12 sec0.10.20.30.3-0.3-0.5-0.5-0.50.3
Patch foraging water rate 18 sec0.10.10.20.4-0.3-0.4-0.4-0.3-0.2
Patch foraging water rate 24 sec0.40.61.00.4-0.5-0.8-0.8-1.00.9
Patch foraging water rate 6 sec0.60.81.01.0-1.0-1.0-1.0-0.90.3
Seeking ratio, delayed vs. immediate footshock1.82.12.8-1.71.61.51.51.5-0.7
Distance traveled before self-admin0.00.00.10.1-0.1-0.2-0.2-0.1-0.1
Distance traveled after self-admin0.30.40.6-0.80.80.50.50.5-0.6
Extensor digitorum longus weight1.76.88.22.8-2.9-2.7-2.7-2.61.5
Bone: elastic displacement0.70.81.0-0.90.91.01.00.8-0.5
Bone: elastic work0.10.10.10.4-0.4-0.2-0.2-0.30.1
Bone: endosteal estimation0.00.00.10.2-0.10.20.20.2-0.3
Bone: endosteal perimeter0.00.00.00.2-0.10.00.0-0.1-0.1
Epididymis fat weight0.10.40.7-0.50.50.80.80.7-0.6
Delta time in closed arm before/after self-admin0.40.40.9-0.90.90.40.40.40.2
Delta time in open arm before/after self-admin0.20.20.50.5-0.50.00.00.1-0.7
Diff in mean of infusions in LGA sessions1.31.62.7-1.61.51.31.31.1-0.6
Delay discount exponential model param1.01.11.30.8-0.9-1.1-1.1-1.11.1
Extinction: sum of active levers before priming0.00.00.1-0.20.20.20.2-0.00.2
Active lever presses in extinction session 60.20.20.30.6-0.5-0.3-0.3-0.4-0.1
Bone: final force0.40.70.90.9-0.9-0.8-0.8-0.90.5
Bone: final moment0.61.01.31.2-1.1-1.0-1.0-1.00.5
Food consumed during 24 hour testing period4.66.37.1-2.72.72.72.72.6-1.6
Glucose0.30.50.9-0.90.90.70.70.60.0
Heart weight1.82.83.31.6-1.7-1.8-1.8-1.81.2
Delay discount hyperbolic model param0.91.01.20.8-0.8-1.1-1.1-1.11.0
Intermittent access intake day 1-15 change0.10.20.20.5-0.5-0.4-0.4-0.40.3
Intermittent access intake escalation0.10.30.40.7-0.6-0.5-0.5-0.50.2
Intermittent access intake escalation 20.00.10.1-0.30.30.0-0.0-0.10.4
Intermitt. access day 1 inactive lever presses0.00.10.20.5-0.4-0.1-0.1-0.1-0.3
Intermitt. access day 15 inactive lever presses0.00.00.10.2-0.3-0.1-0.1-0.00.1
Intermitt. access escalation Index0.20.30.4-0.60.60.50.50.6-0.1
Intermittent access day 1 total infusions1.82.84.52.1-2.1-1.7-1.6-1.50.6
Intermittent access day 15 total infusions0.91.42.11.4-1.4-1.1-1.1-1.00.6
Intermittent access terminal intake (last 3 days)1.21.51.91.4-1.4-1.3-1.3-1.21.0
Intermittent access total infusions2.63.03.81.9-2.0-1.8-1.8-1.71.3
Intermittent access day 1 locomotion0.40.51.01.0-1.0-0.7-0.7-0.60.1
Intermittent access day 15 total locomotion0.10.30.40.6-0.6-0.5-0.5-0.50.0
Intermittent access total locomotion1.61.92.61.6-1.6-1.4-1.4-1.40.7
Intermittent access standard deviation0.10.20.3-0.50.50.50.50.4-0.1
Left kidney weight5.324.631.45.6-5.6-5.2-5.1-4.92.8
Right kidney weight4.821.926.65.2-5.2-4.9-4.9-4.82.8
Cocaine induced anxiety0.10.10.3-0.00.00.40.40.4-0.6
Post-drug Anxiety0.00.00.0-0.10.10.20.20.1-0.1
Baseline Anxiety0.40.51.0-1.00.90.20.1-0.00.9
Tail length0.52.03.71.9-1.9-1.3-1.3-1.20.2
Length with tail0.52.03.41.9-1.8-1.3-1.3-1.20.3
Length without tail0.31.11.51.2-1.2-1.1-1.1-1.00.7
Times rat made contact with spout0.10.10.2-0.40.40.20.20.20.1
Lifetime Intake2.73.34.42.1-2.1-1.8-1.8-1.71.2
Liver weight, left2.23.64.42.1-2.1-2.0-2.0-2.00.9
Liver weight, right1.72.94.62.1-2.1-1.6-1.6-1.70.7
Locomotor activity1.82.93.41.6-1.6-1.8-1.8-1.81.3
Locomotor testing distance1.01.72.11.4-1.4-1.5-1.4-1.30.7
Locomotor testing rearing4.08.19.83.1-3.1-3.0-3.0-2.91.6
Locomotion in novel chamber0.40.51.1-1.01.00.60.50.60.1
Locomotion in novel chamber post-restriction0.91.41.8-1.31.31.21.21.3-0.6
Fecal boli incidents, locomotor time 10.10.10.20.5-0.4-0.2-0.2-0.1-0.3
Change in fecal boli incidents, locomotor task0.50.50.7-0.60.70.90.90.8-0.6
Time >=10cm from walls, locomotor time 10.00.00.1-0.00.00.00.00.1-0.3
Bouts of movement, locomotor time 12.12.42.9-1.71.71.71.71.6-0.9
Total resting periods, locomotor time 12.73.03.5-1.81.81.91.91.8-1.1
Rest time, locomotor task time 10.10.20.2-0.40.40.50.50.5-0.3
Distance moved, locomotor task time 10.30.50.60.7-0.7-0.7-0.7-0.80.6
Vertical activity count, locomotor time 10.00.10.20.4-0.3-0.0-0.0-0.1-0.4
Time >=10cm from walls, locomotor time 20.00.10.1-0.20.20.30.30.3-0.3
Bouts of movement, locomotor time 24.57.29.9-3.13.12.82.82.6-1.3
Total resting periods, locomotor time 23.86.69.6-3.13.02.62.62.5-1.1
Rest time, locomotor task time 20.10.10.3-0.50.50.20.20.20.2
Distance moved, locomotor task time 20.81.01.21.1-1.1-1.0-1.0-1.00.6
Vertical activity count, locomotor time 20.10.10.50.4-0.30.20.20.1-0.7
Light reinforcement 10.00.10.20.4-0.4-0.4-0.4-0.2-0.1
Light reinforcement 20.30.41.01.0-0.9-0.4-0.4-0.1-0.5
Bone: marrow area0.00.00.10.3-0.20.10.10.1-0.3
Bone: maximum diameter2.24.24.92.2-2.2-2.1-2.1-2.21.4
Bone: maximum force0.20.30.50.7-0.7-0.5-0.5-0.60.3
Bone: maximum moment0.30.50.70.8-0.8-0.7-0.7-0.70.3
Mean time between licks in bursts0.00.00.1-0.10.10.20.20.2-0.2
Mean num. licks in bursts2.74.25.1-2.22.32.12.12.2-1.3
Cd content in liver0.20.20.5-0.70.60.30.30.30.2
Co content in liver1.11.31.5-1.21.21.21.21.2-0.5
Cu content in liver0.30.40.50.7-0.7-0.6-0.7-0.60.3
Fe content in liver4.25.16.62.1-2.2-2.4-2.5-2.61.8
K content in liver0.30.30.60.8-0.7-0.4-0.4-0.4-0.3
Mg content in liver0.70.71.11.1-1.0-0.8-0.8-0.80.1
Mn content in liver1.01.11.61.3-1.2-1.1-1.1-1.00.3
Na content in liver0.10.10.20.0-0.1-0.4-0.4-0.40.2
Rb content in liver0.00.00.10.2-0.1-0.3-0.3-0.20.1
Se content in liver3.74.35.12.3-2.3-2.2-2.2-2.21.1
Sr content in liver0.00.00.00.2-0.2-0.2-0.2-0.20.1
Zn content in liver0.80.91.31.1-1.1-1.0-1.0-0.90.3
Bone: minimum diameter0.20.30.50.7-0.7-0.6-0.6-0.60.1
Time in familiar zone, hab. session 10.10.10.10.2-0.2-0.4-0.4-0.30.4
Time in novel zone, hab. session 10.70.70.80.9-0.9-0.8-0.8-0.90.5
Total zone transitions, hab. session 10.10.10.20.2-0.2-0.4-0.4-0.40.4
Total locomotion distance, hab. session 10.30.50.6-0.70.70.70.70.8-0.5
Locomotion velocity, hab. session 11.11.61.9-1.21.31.31.31.4-1.0
Time in familiar zone, hab. session 20.30.30.40.6-0.6-0.6-0.6-0.70.4
Time in novel zone, hab. session 20.20.20.3-0.60.60.30.30.2-0.1
Total zone transitions, hab. session 20.40.50.80.7-0.7-0.8-0.8-0.90.5
Total locomotion distance, hab. session 20.40.60.7-0.80.80.80.80.7-0.6
Locomotion velocity, hab. session 20.30.40.5-0.60.60.70.70.7-0.6
Novel to familiar place preference ratio0.40.40.60.7-0.6-0.7-0.7-0.50.4
Novelty place preference0.30.30.50.6-0.6-0.7-0.7-0.40.4
Time in novel zone, NPP test0.40.40.60.6-0.6-0.8-0.8-0.50.5
Total zone transitions, NPP test0.10.10.10.3-0.3-0.4-0.4-0.40.4
Total locomotion distance, NPP test0.10.10.20.1-0.1-0.3-0.3-0.30.5
Locomotion velocity, NPP test0.00.10.10.1-0.1-0.2-0.3-0.20.3
Intraocular pressure0.20.20.5-0.70.60.20.1-0.00.7
Delta distance traveled before/after self-admin1.31.41.9-0.80.91.31.31.2-1.4
Delta ambulatory time before/after self-admin0.30.40.7-0.30.40.60.60.6-0.8
Parametrial fat weight0.10.20.40.6-0.6-0.4-0.4-0.40.1
Pavlov. Cond. lever latency0.50.60.8-0.90.90.80.80.9-0.4
Pavlov. Cond. magazine entry latency0.10.10.20.5-0.5-0.3-0.3-0.40.1
Pavlov. Cond. change in total contacts0.50.50.6-0.70.70.80.80.7-0.4
Pavlov. Cond. index score0.30.40.50.7-0.7-0.6-0.6-0.70.3
Pavlov. Cond. latency score0.10.10.10.4-0.4-0.3-0.3-0.40.1
Pavlov. Cond. lever contacts0.40.40.60.7-0.8-0.7-0.7-0.70.3
Pavlov. Cond. magazine entry number0.00.10.1-0.30.30.20.20.30.0
Pavlov. Cond. intertrial magazine entries0.10.10.30.1-0.1-0.2-0.2-0.20.5
Pavlov. Cond. lever-magazine prob. diff.0.30.40.50.6-0.7-0.6-0.6-0.70.3
Pavlov. Cond. response bias0.91.11.41.2-1.2-1.1-1.1-1.10.5
Pavlov. Cond. lever latency0.00.00.0-0.20.20.10.10.1-0.0
Pavlov. Cond. magazine entry latency0.00.00.10.1-0.1-0.1-0.1-0.00.2
Pavlov. Cond. change in total contacts0.20.40.5-0.70.70.60.60.6-0.4
Pavlov. Cond. index score0.00.00.1-0.10.10.20.20.2-0.2
Pavlov. Cond. latency score0.10.10.1-0.20.20.30.30.3-0.2
Pavlov. Cond. lever contacts0.10.10.20.4-0.4-0.3-0.3-0.30.1
Pavlov. Cond. magazine entry number0.30.30.50.6-0.6-0.6-0.6-0.70.3
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.10.1-0.1-0.1-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.1-0.1-0.0-0.00.1-0.0
Pavlov. Cond. response bias0.00.00.00.0-0.00.10.10.1-0.0
Time in closed arm before self-admin0.60.80.90.9-0.9-1.0-1.0-0.80.7
Time in closed arm after self-admin1.11.22.1-1.51.41.01.01.1-0.2
Time in open arm before self-admin0.60.70.9-0.80.90.90.90.7-0.6
Time in open arm after self-admin0.10.10.30.3-0.20.20.20.1-0.5
Bone: periosteal estimation0.30.61.11.0-1.0-0.8-0.7-0.80.3
Bone: periosteal perimeter0.30.60.90.9-0.9-0.7-0.7-0.80.3
Bone: post-yield work0.60.91.2-0.70.81.01.01.1-1.0
Progressive ratio test 1 active lever presses2.93.65.42.3-2.3-1.9-1.9-1.70.8
Progressive ratio test 1 breakpoint2.83.45.62.4-2.3-1.8-1.8-1.60.7
Progressive ratio test 1 inactive lever presses1.52.13.31.8-1.8-1.4-1.4-1.30.3
Progressive ratio test 2 active lever presses2.63.14.42.1-2.1-1.8-1.7-1.70.8
Progressive ratio test 2 breakpoint2.93.44.82.2-2.2-1.8-1.8-1.80.9
Progressive ratio test 2 inactive lever presses0.50.71.81.3-1.3-0.6-0.6-0.4-0.3
Incentive Sensitization - Responses1.21.82.41.5-1.5-1.3-1.3-1.30.6
Incentive Sensitization - Breakpoint1.21.62.11.5-1.5-1.3-1.3-1.30.6
Sum of active levers in priming session hrs 5-60.40.30.8-0.90.80.50.50.30.2
Progressive ratio0.81.21.6-1.11.11.21.21.1-0.6
Food seeking constrained by brief footshock5.06.27.1-2.62.62.62.62.7-1.8
Seeking ratio, punishment vs. effort0.60.91.2-0.90.90.90.91.1-0.9
Retroperitoneal fat weight0.00.10.20.4-0.4-0.3-0.3-0.40.3
Reaction time number correct3.16.07.92.2-2.2-2.7-2.7-2.81.9
Reaction time mean minus median0.30.81.9-1.41.30.60.50.40.7
Reaction time mean minus median AUC0.10.31.3-0.60.5-0.2-0.2-0.31.1
Reaction time num false alarms4.66.48.73.0-2.9-2.6-2.6-2.51.3
Reaction time num false alarms AUC3.65.78.12.8-2.8-2.4-2.4-2.31.1
Reaction time trials correct on left3.16.07.92.2-2.2-2.7-2.7-2.81.9
Reaction time trials on left3.26.07.92.2-2.3-2.7-2.7-2.81.9
Reaction time mean1.32.13.1-1.81.71.51.41.4-0.3
Reaction time mean AUC1.01.72.7-1.61.61.31.31.2-0.2
Median of all reaction times1.42.02.4-1.61.61.51.51.5-0.6
Reaction time omissions0.00.00.10.1-0.2-0.0-0.00.00.3
Reaction time false alarm rate0.30.51.11.1-1.0-0.5-0.5-0.4-0.0
Reaction time premature initiation rate0.40.61.0-0.40.50.70.80.9-1.0
Reaction time premature initiations0.10.30.40.5-0.5-0.6-0.6-0.60.0
Std. dev. reaction times0.40.81.7-1.31.20.70.70.60.4
Reaction time trials completed3.26.07.92.2-2.3-2.7-2.7-2.81.9
Reaction time trials AUC3.97.49.52.5-2.5-3.0-3.0-3.12.1
Run reversals in cocaine runway, females0.30.30.5-0.30.30.50.50.7-0.7
Run reversals in cocaine runway, males0.40.40.50.6-0.6-0.7-0.7-0.70.6
Latency to leave start box in cocaine runway0.00.00.1-0.30.3-0.1-0.10.10.2
Latency to leave start box in cocaine runway, F0.30.40.60.3-0.2-0.7-0.7-0.60.8
Latency to leave start box in cocaine runway, M0.20.10.2-0.40.40.30.40.5-0.4
Std. dev. time between licks in bursts0.00.10.20.4-0.4-0.2-0.2-0.1-0.0
Total sessions with >9 infusions3.74.55.12.2-2.2-2.2-2.2-2.11.6
Short access day 1 total inactive lever presses1.31.74.12.0-1.9-1.0-1.0-0.8-0.2
Short access day 10 total inactive lever presses0.51.11.4-1.11.11.21.21.1-0.8
Short access day 1 total infusions2.12.83.31.8-1.8-1.7-1.7-1.71.3
Short access day 10 total infusions3.74.76.12.5-2.4-2.2-2.2-2.11.4
Short access total infusions2.53.24.32.1-2.1-1.8-1.8-1.71.1
Short access day 1 locomotion3.64.56.42.5-2.5-2.1-2.1-2.01.1
Short access day 10 total locomotion0.00.00.0-0.20.1-0.0-0.0-0.10.2
Short access total locomotion0.81.01.41.2-1.2-1.0-1.0-0.90.5
One hour access (0.3 mA shock)0.10.10.20.4-0.4-0.2-0.2-0.20.1
Compulsive drug intake0.10.10.20.1-0.1-0.4-0.4-0.40.5
One hour access (shock baseline)1.01.62.31.5-1.5-1.2-1.2-1.10.8
Social response proportion0.70.81.00.8-0.8-1.0-1.0-0.90.6
Social responses0.70.91.11.0-1.0-1.0-1.0-0.90.5
Social time3.14.35.5-1.71.82.12.22.4-2.1
Soleus weight0.10.30.40.7-0.7-0.6-0.6-0.50.3
Bone: stiffness0.71.11.51.2-1.2-1.1-1.1-1.10.5
Tibialis anterior weight3.110.412.83.6-3.6-3.4-3.4-3.31.8
Time to tail flick, vehicle, before self-admin2.52.63.31.5-1.5-1.8-1.8-1.81.1
Time to tail flick, vehicle, after self-admin0.10.10.4-0.60.60.0-0.0-0.00.4
Time to tail flick, test, before self-admin0.30.30.4-0.60.50.60.60.50.2
Time to tail flick, test, after self-admin0.20.20.70.00.10.30.30.5-0.8
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.70.70.40.40.40.0
Delta time to tail flick, test, before/after SA0.70.71.11.1-1.0-1.0-0.9-0.8-0.1
Tibia length0.30.91.61.3-1.2-0.8-0.8-0.80.6
Ambulatory time before self-admin0.00.00.1-0.20.20.10.10.0-0.2
Ambulatory time after self-admin0.60.71.1-1.01.00.70.70.7-0.8
Bone: tissue strength0.80.81.0-0.90.90.90.91.0-0.7
Total heroin consumption0.00.00.10.2-0.20.00.00.0-0.3
Bone: trabecular number0.00.00.0-0.10.10.20.20.1-0.2
Bone: trabecular spacing0.00.00.00.1-0.0-0.2-0.2-0.10.1
Bone: trabecular thickness1.41.82.31.4-1.4-1.4-1.4-1.51.0
Bone: trabecular tissue density0.30.40.50.6-0.6-0.7-0.7-0.70.6
Water consumed over 24 hours0.20.20.4-0.70.60.40.40.5-0.1
Number of responses in last shaping day2.93.24.31.5-1.6-1.8-1.8-1.82.1