Hub : Genes

Qpctl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	isoform ratio	XR_005501477.2	0.08	0.2	2.7e-03	0.03	0.02	0.02	0.03	5.2e-04	3.5e-03	2.5e-03	7.7e-04
2	Adipose	alternative polyA	XM_063283177.1	0.04	0.04	3.6e-04	0.03	0.03	0.03	0.03	2.7e-04	4.0e-04	2.9e-04	2.0e-04
3	Brain	gene expression	Qpctl	0.03	0.03	4.6e-03	0.02	0.02	0	0.02	7.6e-03	4.0e-03	2.2e-01	8.4e-03
4	NAcc	intron excision ratio	chr1_87919724_87921201	0.01	0.01	6.6e-03	0.01	0.01	0	0.01	1.4e-02	1.1e-02	8.0e-02	2.2e-02
5	PL	gene expression	Qpctl	0.09	0.07	2.4e-10	0.09	0.09	0.09	0.09	1.9e-10	4.9e-10	3.4e-10	4.7e-10
6	Liver	gene expression	Qpctl	0.08	0.1	3.2e-03	0.01	0.01	0.02	0.01	1.6e-02	4.3e-02	4.5e-03	5.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.0	0.1	0.1
Area under the delay curve	1.0	1.5	1.8	1.0	1.0	1.3	1.4	-1.3	1.3
BMI with tail	0.7	2.5	4.3	-2.1	-2.0	-1.5	-1.5	1.5	-0.5
BMI without tail	0.6	3.2	5.9	-2.4	-2.4	-1.6	-1.6	1.5	-0.3
Body weight	1.4	6.3	10.4	-3.2	-3.2	-2.4	-2.4	2.3	-0.9
Weight adjusted by age	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.0	0.1
Bone surface	0.2	0.5	0.8	-0.9	-0.9	-0.7	-0.7	0.6	-0.1
Bone volume	0.2	0.3	0.4	-0.7	-0.7	-0.6	-0.6	0.6	-0.2
Breakpoint value in progressive ratio session	1.3	2.4	3.3	1.8	1.7	1.7	1.6	-1.5	0.8
Number of licking bursts	1.2	3.6	4.5	-1.9	-1.9	-2.0	-2.0	2.1	-1.4
Context. condit. distance diff. score	0.1	0.1	0.2	-0.1	-0.1	-0.3	-0.3	0.4	-0.4
Locomotion velocity, session 1	0.1	0.1	0.3	0.5	0.5	0.3	0.3	-0.1	-0.3
Locomotion distance, session 1	0.0	0.0	0.1	0.2	0.2	-0.1	-0.1	0.0	-0.4
Locomotion velocity, session 2	1.3	1.6	2.1	-1.5	-1.4	-1.3	-1.3	1.3	-0.6
Locomotion distance, session 2	0.2	0.3	0.4	-0.6	-0.6	-0.6	-0.6	0.5	-0.3
Locomotion velocity, session 3	0.2	0.3	0.5	-0.7	-0.7	-0.5	-0.5	0.4	0.0
Locomotion distance, session 3	0.7	0.8	1.1	0.7	0.8	0.9	0.9	-1.0	1.0
Stereotopy head waving bouts, day 3	0.9	1.1	1.4	-1.0	-1.1	-1.1	-1.1	1.2	-0.8
Stereotopy head waving duration, day 3	0.8	1.0	1.5	-0.9	-0.9	-1.1	-1.1	1.2	-0.9
Locomotion velocity, session 7	0.2	0.2	0.3	0.5	0.5	0.4	0.4	-0.5	0.1
Locomotion distance, session 7	0.0	0.0	0.1	-0.3	-0.2	-0.1	-0.1	-0.1	-0.0
Stereotopy head waving bouts, day 7	0.9	1.1	1.6	-0.8	-0.9	-1.1	-1.1	1.3	-1.0
Stereotopy head waving duration, day 7	0.7	0.9	1.3	-0.8	-0.9	-1.0	-1.0	1.1	-0.8
Locomotion velocity, session 8	0.0	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	-0.0
Locomotion distance, session 8	0.0	0.0	0.0	-0.0	-0.0	-0.1	-0.0	-0.0	-0.1
Degree of sensitization distance	0.5	0.5	0.6	-0.7	-0.7	-0.8	-0.8	0.7	-0.7
Degree of sensitization stereotypy	1.0	1.1	1.5	-0.9	-0.9	-1.1	-1.1	1.2	-1.0
Conditioned locomotion	0.0	0.1	0.1	0.3	0.3	0.2	0.2	-0.3	0.1
Cocaine response after cond. corrected	0.4	0.6	0.7	-0.6	-0.6	-0.8	-0.8	0.8	-0.8
Cocaine response after cond. not corrected	1.0	1.5	1.7	-1.2	-1.2	-1.3	-1.3	1.3	-1.1
Cocaine response before conditioning	1.6	1.9	2.3	-1.5	-1.5	-1.4	-1.4	1.4	-1.0
Saline control response	1.7	2.4	2.8	-1.6	-1.6	-1.7	-1.7	1.7	-0.9
Bone: connectivity density	0.0	0.1	0.2	-0.1	-0.1	0.1	0.2	-0.3	0.4
Bone: cortical apparent density	0.0	0.0	0.1	0.2	0.2	0.2	0.3	-0.3	0.0
Bone: cortical area	1.4	2.3	2.6	-1.6	-1.6	-1.6	-1.6	1.6	-0.9
Bone: cortical porosity	0.1	0.2	0.2	0.4	0.4	0.4	0.4	-0.4	0.3
Bone: cortical porosity	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.0	0.1	0.1
Bone: cortical thickness	0.5	0.9	1.1	-0.9	-0.9	-1.0	-1.0	1.0	-0.7
Bone: cortical thickness	1.3	1.5	1.9	-1.2	-1.2	-1.3	-1.3	1.4	-0.9
Bone: cortical tissue density	0.1	0.1	0.1	0.3	0.3	0.4	0.4	-0.4	0.1
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	-1.0	-1.0	-0.7	-0.7	0.8	-0.4
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.7	-0.9	-0.8	-0.6	-0.6	0.7	-0.3
Condit. Reinf. active responses	0.3	0.4	0.6	-0.8	-0.8	-0.6	-0.6	0.6	-0.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.3	0.3	0.2	0.3	-0.4	0.2
Incentive salience index mean	0.4	0.5	0.9	-1.0	-0.9	-0.6	-0.6	0.7	-0.2
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.6	-0.6	-0.2	-0.2	0.2	0.2
Condit. Reinf. active minus inactive responses	0.0	0.1	0.2	-0.1	-0.2	-0.3	-0.3	0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.3	-0.3	-0.6	-0.6	0.5	-0.6
Condit. Reinf. active responses	0.0	0.1	0.1	0.3	0.3	0.3	0.3	-0.2	0.0
Condit. Reinf. inactive responses	0.4	0.6	0.8	0.8	0.8	0.9	0.9	-0.7	0.5
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.5	-0.5	-0.4	-0.4	0.4	-0.2
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	0.4	0.4	0.4	0.4	-0.3	0.1
Conditioned reinforcement - actives	0.6	2.3	3.6	-1.9	-1.8	-1.6	-1.5	1.4	-0.5
Conditioned reinforcement - inactives	0.4	1.2	2.4	-1.6	-1.5	-0.9	-0.9	0.8	0.2
Conditioned locomotion	1.6	2.4	2.8	-1.4	-1.4	-1.7	-1.7	1.7	-1.4
Patch foraging indifference point 0 sec	0.2	0.5	0.8	-0.4	-0.4	-0.8	-0.8	0.9	-0.8
Patch foraging indifference point AUC	2.0	4.7	6.5	-2.5	-2.5	-2.2	-2.2	2.1	-1.2
Delay disc. indifference point, 0s delay	0.8	1.0	1.3	0.7	0.7	1.1	1.1	-1.1	1.1
Delay disc. indifference point, 16s delay	0.6	0.9	1.3	0.6	0.7	1.0	1.1	-1.1	1.2
Delay disc. indifference point, 2s delay	2.7	3.1	3.9	1.3	1.4	1.9	1.9	-2.0	1.9
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.0	0.0	-0.2	-0.2	0.2	-0.1
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	-0.1	-0.1	0.0	0.0	-0.1	0.0
Delay disc. indifference point, 8s delay	0.9	1.6	1.9	1.3	1.3	1.4	1.4	-1.3	0.8
Indifference point function ln k	0.7	2.2	4.0	2.0	2.0	1.3	1.3	-1.2	0.4
Indifference point function log k	0.7	2.2	4.0	2.0	2.0	1.3	1.3	-1.2	0.4
Patch foraging total patch changes 0 sec	0.2	0.7	1.1	-0.5	-0.6	-1.0	-1.0	1.1	-0.8
Patch foraging total patch changes 12 sec	1.7	2.2	3.4	-1.8	-1.8	-1.4	-1.4	1.4	-0.6
Patch foraging total patch changes 18 sec	1.1	2.6	3.4	-1.4	-1.5	-1.7	-1.7	1.8	-1.4
Patch foraging total patch changes 24 sec	0.2	0.7	1.1	-1.0	-1.0	-0.8	-0.8	0.8	-0.3
Patch foraging total patch changes 6 sec	1.9	3.3	3.9	-1.8	-1.8	-1.9	-1.9	2.0	-1.2
Patch foraging time to switch 0 sec	1.1	4.1	5.1	2.1	2.1	2.3	2.3	-2.1	1.3
Patch foraging water rate 0 sec	1.3	5.0	6.0	-2.3	-2.3	-2.5	-2.4	2.4	-1.4
Patch foraging water rate 12 sec	0.0	0.2	0.3	-0.3	-0.3	-0.5	-0.5	0.5	-0.3
Patch foraging water rate 18 sec	0.1	0.1	0.2	-0.4	-0.3	-0.4	-0.4	0.3	0.2
Patch foraging water rate 24 sec	0.4	0.6	1.0	-0.4	-0.5	-0.8	-0.8	1.0	-0.9
Patch foraging water rate 6 sec	0.6	0.8	1.0	-1.0	-1.0	-1.0	-1.0	0.9	-0.3
Seeking ratio, delayed vs. immediate footshock	1.5	2.1	2.8	1.7	1.6	1.5	1.5	-1.5	0.7
Distance traveled before self-admin	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.2	0.1	0.1
Distance traveled after self-admin	0.2	0.4	0.6	0.8	0.8	0.5	0.5	-0.5	0.6
Extensor digitorum longus weight	1.7	6.8	8.2	-2.8	-2.9	-2.7	-2.7	2.6	-1.5
Bone: elastic displacement	0.6	0.8	1.0	0.9	0.9	1.0	1.0	-0.8	0.5
Bone: elastic work	0.1	0.1	0.1	-0.4	-0.4	-0.2	-0.2	0.3	-0.1
Bone: endosteal estimation	0.0	0.0	0.1	-0.2	-0.1	0.2	0.2	-0.2	0.3
Bone: endosteal perimeter	0.0	0.0	0.0	-0.2	-0.1	0.0	0.0	0.1	0.1
Epididymis fat weight	0.1	0.4	0.7	0.5	0.5	0.8	0.8	-0.7	0.6
Delta time in closed arm before/after self-admin	0.4	0.4	0.9	0.9	0.9	0.4	0.4	-0.4	-0.2
Delta time in open arm before/after self-admin	0.1	0.2	0.5	-0.5	-0.5	0.0	0.0	-0.1	0.7
Diff in mean of infusions in LGA sessions	0.9	1.6	2.7	1.6	1.5	1.3	1.3	-1.1	0.6
Delay discount exponential model param	0.8	1.1	1.3	-0.8	-0.9	-1.1	-1.1	1.1	-1.1
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.2	0.2	0.2	0.2	0.0	-0.2
Active lever presses in extinction session 6	0.2	0.2	0.3	-0.6	-0.5	-0.3	-0.3	0.4	0.1
Bone: final force	0.4	0.7	0.9	-0.9	-0.9	-0.8	-0.8	0.9	-0.5
Bone: final moment	0.6	1.0	1.3	-1.2	-1.1	-1.0	-1.0	1.0	-0.5
Food consumed during 24 hour testing period	3.1	6.3	7.1	2.7	2.7	2.7	2.7	-2.6	1.6
Glucose	0.3	0.5	0.9	0.9	0.9	0.7	0.7	-0.6	-0.0
Heart weight	1.7	2.8	3.3	-1.6	-1.7	-1.8	-1.8	1.8	-1.2
Delay discount hyperbolic model param	0.7	1.0	1.2	-0.8	-0.8	-1.1	-1.1	1.1	-1.0
Intermittent access intake day 1-15 change	0.0	0.2	0.2	-0.5	-0.5	-0.4	-0.4	0.4	-0.3
Intermittent access intake escalation	0.0	0.3	0.4	-0.7	-0.6	-0.5	-0.5	0.5	-0.2
Intermittent access intake escalation 2	0.0	0.1	0.1	0.3	0.3	0.0	-0.0	0.1	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.5	-0.4	-0.1	-0.1	0.1	0.3
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.1	0.0	-0.1
Intermitt. access escalation Index	0.1	0.3	0.4	0.6	0.6	0.5	0.5	-0.6	0.1
Intermittent access day 1 total infusions	1.0	2.8	4.5	-2.1	-2.1	-1.7	-1.6	1.5	-0.6
Intermittent access day 15 total infusions	0.6	1.4	2.1	-1.4	-1.4	-1.1	-1.1	1.0	-0.6
Intermittent access terminal intake (last 3 days)	0.9	1.5	1.9	-1.4	-1.4	-1.3	-1.3	1.2	-1.0
Intermittent access total infusions	2.6	3.0	3.8	-1.9	-2.0	-1.8	-1.8	1.7	-1.3
Intermittent access day 1 locomotion	0.3	0.5	1.0	-1.0	-1.0	-0.7	-0.7	0.6	-0.1
Intermittent access day 15 total locomotion	0.1	0.3	0.4	-0.6	-0.6	-0.5	-0.5	0.5	-0.0
Intermittent access total locomotion	1.6	1.9	2.6	-1.6	-1.6	-1.4	-1.4	1.4	-0.7
Intermittent access standard deviation	0.0	0.2	0.3	0.5	0.5	0.5	0.5	-0.4	0.1
Left kidney weight	3.1	24.6	31.4	-5.6	-5.6	-5.2	-5.1	4.9	-2.8
Right kidney weight	3.1	21.9	26.5	-5.2	-5.2	-4.9	-4.9	4.8	-2.8
Cocaine induced anxiety	0.1	0.1	0.3	0.0	0.0	0.4	0.4	-0.4	0.6
Post-drug Anxiety	0.0	0.0	0.0	0.1	0.1	0.2	0.2	-0.1	0.1
Baseline Anxiety	0.3	0.5	1.0	1.0	0.9	0.2	0.1	0.0	-0.9
Tail length	0.4	2.0	3.7	-1.9	-1.9	-1.3	-1.3	1.2	-0.2
Length with tail	0.4	2.0	3.4	-1.9	-1.8	-1.3	-1.3	1.2	-0.3
Length without tail	0.2	1.1	1.5	-1.2	-1.2	-1.1	-1.1	1.0	-0.7
Times rat made contact with spout	0.1	0.1	0.2	0.4	0.4	0.2	0.2	-0.2	-0.1
Lifetime Intake	2.6	3.3	4.4	-2.1	-2.1	-1.8	-1.8	1.7	-1.2
Liver weight, left	2.1	3.6	4.4	-2.1	-2.1	-2.0	-2.0	2.0	-0.9
Liver weight, right	1.7	2.9	4.6	-2.1	-2.1	-1.6	-1.6	1.7	-0.7
Locomotor activity	1.8	2.9	3.4	-1.6	-1.6	-1.8	-1.8	1.8	-1.3
Locomotor testing distance	0.7	1.7	2.1	-1.4	-1.4	-1.5	-1.4	1.3	-0.7
Locomotor testing rearing	2.2	8.1	9.8	-3.1	-3.1	-3.0	-3.0	2.9	-1.6
Locomotion in novel chamber	0.4	0.5	1.1	1.0	1.0	0.6	0.5	-0.6	-0.1
Locomotion in novel chamber post-restriction	0.5	1.4	1.8	1.3	1.3	1.2	1.2	-1.3	0.6
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	-0.5	-0.4	-0.2	-0.2	0.1	0.3
Change in fecal boli incidents, locomotor task	0.5	0.5	0.7	0.6	0.7	0.9	0.9	-0.8	0.6
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.0	0.0	0.0	0.0	-0.1	0.3
Bouts of movement, locomotor time 1	1.9	2.4	2.9	1.7	1.7	1.7	1.7	-1.6	0.9
Total resting periods, locomotor time 1	2.6	3.0	3.5	1.8	1.8	1.9	1.9	-1.8	1.1
Rest time, locomotor task time 1	0.1	0.2	0.2	0.4	0.4	0.5	0.5	-0.5	0.3
Distance moved, locomotor task time 1	0.2	0.5	0.6	-0.7	-0.7	-0.7	-0.7	0.8	-0.6
Vertical activity count, locomotor time 1	0.0	0.1	0.2	-0.4	-0.3	-0.0	-0.0	0.1	0.4
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	0.2	0.2	0.3	0.3	-0.3	0.3
Bouts of movement, locomotor time 2	2.2	7.2	9.9	3.1	3.1	2.8	2.8	-2.6	1.3
Total resting periods, locomotor time 2	1.6	6.6	9.6	3.1	3.0	2.6	2.6	-2.5	1.1
Rest time, locomotor task time 2	0.1	0.1	0.3	0.5	0.5	0.2	0.2	-0.2	-0.2
Distance moved, locomotor task time 2	0.7	1.0	1.2	-1.1	-1.1	-1.0	-1.0	1.0	-0.6
Vertical activity count, locomotor time 2	0.1	0.1	0.5	-0.4	-0.3	0.2	0.2	-0.1	0.7
Light reinforcement 1	0.0	0.1	0.2	-0.4	-0.4	-0.4	-0.4	0.2	0.1
Light reinforcement 2	0.2	0.4	1.0	-1.0	-0.9	-0.4	-0.4	0.1	0.5
Bone: marrow area	0.0	0.0	0.1	-0.3	-0.2	0.1	0.1	-0.1	0.3
Bone: maximum diameter	2.1	4.2	4.9	-2.2	-2.2	-2.1	-2.1	2.2	-1.4
Bone: maximum force	0.2	0.3	0.5	-0.7	-0.7	-0.5	-0.5	0.6	-0.3
Bone: maximum moment	0.2	0.5	0.7	-0.8	-0.8	-0.7	-0.7	0.7	-0.3
Mean time between licks in bursts	0.0	0.0	0.1	0.1	0.1	0.2	0.2	-0.2	0.2
Mean num. licks in bursts	1.6	4.2	5.1	2.2	2.3	2.1	2.1	-2.2	1.3
Cd content in liver	0.2	0.2	0.5	0.7	0.6	0.3	0.3	-0.3	-0.2
Co content in liver	1.1	1.3	1.5	1.2	1.2	1.2	1.2	-1.2	0.5
Cu content in liver	0.3	0.4	0.5	-0.7	-0.7	-0.6	-0.7	0.6	-0.3
Fe content in liver	4.2	5.1	6.6	-2.1	-2.2	-2.4	-2.5	2.6	-1.8
K content in liver	0.3	0.3	0.6	-0.8	-0.7	-0.4	-0.4	0.4	0.3
Mg content in liver	0.6	0.7	1.1	-1.1	-1.0	-0.8	-0.8	0.8	-0.1
Mn content in liver	1.0	1.1	1.6	-1.3	-1.2	-1.1	-1.1	1.0	-0.3
Na content in liver	0.1	0.1	0.2	-0.0	-0.1	-0.4	-0.4	0.4	-0.2
Rb content in liver	0.0	0.0	0.1	-0.2	-0.1	-0.3	-0.3	0.2	-0.1
Se content in liver	3.7	4.3	5.1	-2.3	-2.3	-2.2	-2.2	2.2	-1.1
Sr content in liver	0.0	0.0	0.0	-0.2	-0.2	-0.2	-0.2	0.2	-0.1
Zn content in liver	0.7	0.9	1.3	-1.1	-1.1	-1.0	-1.0	0.9	-0.3
Bone: minimum diameter	0.2	0.3	0.5	-0.7	-0.7	-0.6	-0.6	0.6	-0.1
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.2	-0.2	-0.4	-0.4	0.3	-0.4
Time in novel zone, hab. session 1	0.6	0.7	0.8	-0.9	-0.9	-0.8	-0.8	0.9	-0.5
Total zone transitions, hab. session 1	0.1	0.1	0.2	-0.2	-0.2	-0.4	-0.4	0.4	-0.4
Total locomotion distance, hab. session 1	0.3	0.5	0.6	0.7	0.7	0.7	0.7	-0.8	0.5
Locomotion velocity, hab. session 1	1.1	1.6	1.9	1.2	1.3	1.3	1.3	-1.4	1.0
Time in familiar zone, hab. session 2	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.6	0.7	-0.4
Time in novel zone, hab. session 2	0.1	0.2	0.3	0.6	0.6	0.3	0.3	-0.2	0.1
Total zone transitions, hab. session 2	0.4	0.5	0.8	-0.7	-0.7	-0.8	-0.8	0.9	-0.5
Total locomotion distance, hab. session 2	0.4	0.6	0.7	0.8	0.8	0.8	0.8	-0.7	0.6
Locomotion velocity, hab. session 2	0.3	0.4	0.5	0.6	0.6	0.7	0.7	-0.7	0.6
Novel to familiar place preference ratio	0.3	0.4	0.6	-0.7	-0.6	-0.7	-0.7	0.5	-0.4
Novelty place preference	0.2	0.3	0.5	-0.6	-0.6	-0.7	-0.7	0.4	-0.4
Time in novel zone, NPP test	0.3	0.4	0.6	-0.6	-0.6	-0.8	-0.8	0.5	-0.5
Total zone transitions, NPP test	0.1	0.1	0.1	-0.3	-0.3	-0.4	-0.4	0.4	-0.4
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.1	-0.1	-0.3	-0.3	0.3	-0.5
Locomotion velocity, NPP test	0.0	0.1	0.1	-0.1	-0.1	-0.2	-0.3	0.2	-0.3
Intraocular pressure	0.1	0.2	0.5	0.7	0.6	0.2	0.1	0.0	-0.7
Delta distance traveled before/after self-admin	1.2	1.4	1.9	0.8	0.9	1.3	1.3	-1.2	1.4
Delta ambulatory time before/after self-admin	0.2	0.4	0.7	0.3	0.4	0.6	0.6	-0.6	0.8
Parametrial fat weight	0.1	0.2	0.4	-0.6	-0.6	-0.4	-0.4	0.4	-0.1
Pavlov. Cond. lever latency	0.5	0.6	0.8	0.9	0.9	0.8	0.8	-0.9	0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.5	-0.5	-0.3	-0.3	0.4	-0.1
Pavlov. Cond. change in total contacts	0.4	0.5	0.6	0.7	0.7	0.8	0.8	-0.7	0.4
Pavlov. Cond. index score	0.3	0.4	0.5	-0.7	-0.7	-0.6	-0.6	0.7	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.4	-0.4	-0.3	-0.3	0.4	-0.1
Pavlov. Cond. lever contacts	0.4	0.4	0.6	-0.7	-0.8	-0.7	-0.7	0.7	-0.3
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	0.3	0.3	0.2	0.2	-0.3	-0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.1	-0.1	-0.2	-0.2	0.2	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	-0.6	-0.7	-0.6	-0.6	0.7	-0.3
Pavlov. Cond. response bias	0.9	1.1	1.4	-1.2	-1.2	-1.1	-1.1	1.1	-0.5
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.2	0.2	0.1	0.1	-0.1	0.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	0.0	-0.2
Pavlov. Cond. change in total contacts	0.1	0.4	0.5	0.7	0.7	0.6	0.6	-0.6	0.4
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	0.1	0.2	0.2	-0.2	0.2
Pavlov. Cond. latency score	0.0	0.1	0.1	0.2	0.2	0.3	0.3	-0.3	0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.3	0.3	-0.1
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	-0.6	-0.6	-0.6	-0.6	0.7	-0.3
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.0	-0.1	0.0
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.0	-0.0	0.1	0.1	-0.1	0.0
Time in closed arm before self-admin	0.4	0.8	0.9	-0.9	-0.9	-1.0	-1.0	0.8	-0.7
Time in closed arm after self-admin	1.1	1.2	2.1	1.5	1.4	1.0	1.0	-1.1	0.2
Time in open arm before self-admin	0.6	0.7	0.9	0.8	0.9	0.9	0.9	-0.7	0.6
Time in open arm after self-admin	0.1	0.1	0.3	-0.3	-0.2	0.2	0.2	-0.1	0.5
Bone: periosteal estimation	0.3	0.6	1.1	-1.0	-1.0	-0.8	-0.7	0.8	-0.3
Bone: periosteal perimeter	0.3	0.6	0.9	-0.9	-0.9	-0.7	-0.7	0.8	-0.3
Bone: post-yield work	0.5	0.9	1.2	0.7	0.8	1.0	1.0	-1.1	1.0
Progressive ratio test 1 active lever presses	2.0	3.6	5.4	-2.3	-2.3	-1.9	-1.9	1.7	-0.8
Progressive ratio test 1 breakpoint	2.0	3.4	5.6	-2.4	-2.3	-1.8	-1.8	1.6	-0.7
Progressive ratio test 1 inactive lever presses	0.8	2.1	3.3	-1.8	-1.8	-1.4	-1.4	1.3	-0.3
Progressive ratio test 2 active lever presses	2.2	3.1	4.4	-2.1	-2.1	-1.8	-1.7	1.7	-0.8
Progressive ratio test 2 breakpoint	2.6	3.4	4.8	-2.2	-2.2	-1.8	-1.8	1.8	-0.9
Progressive ratio test 2 inactive lever presses	0.2	0.7	1.8	-1.3	-1.3	-0.6	-0.6	0.4	0.3
Incentive Sensitization - Responses	0.6	1.8	2.4	-1.5	-1.5	-1.3	-1.3	1.3	-0.6
Incentive Sensitization - Breakpoint	0.7	1.6	2.1	-1.5	-1.5	-1.3	-1.3	1.3	-0.6
Sum of active levers in priming session hrs 5-6	0.4	0.3	0.8	0.9	0.8	0.5	0.5	-0.3	-0.2
Progressive ratio	0.4	1.2	1.6	1.1	1.1	1.2	1.2	-1.1	0.6
Food seeking constrained by brief footshock	4.9	6.2	7.1	2.6	2.6	2.6	2.6	-2.7	1.8
Seeking ratio, punishment vs. effort	0.4	0.9	1.2	0.9	0.9	0.9	0.9	-1.1	0.9
Retroperitoneal fat weight	0.0	0.1	0.2	-0.4	-0.4	-0.3	-0.3	0.4	-0.3
Reaction time number correct	1.7	6.0	7.9	-2.2	-2.2	-2.7	-2.7	2.8	-1.9
Reaction time mean minus median	0.1	0.8	1.9	1.4	1.3	0.6	0.5	-0.4	-0.7
Reaction time mean minus median AUC	0.1	0.3	1.3	0.6	0.5	-0.2	-0.2	0.3	-1.1
Reaction time num false alarms	3.8	6.4	8.7	-3.0	-2.9	-2.6	-2.6	2.5	-1.3
Reaction time num false alarms AUC	2.5	5.7	8.1	-2.8	-2.8	-2.4	-2.4	2.3	-1.1
Reaction time trials correct on left	1.7	6.0	7.9	-2.2	-2.2	-2.7	-2.7	2.8	-1.9
Reaction time trials on left	1.8	6.0	7.9	-2.2	-2.3	-2.7	-2.7	2.8	-1.9
Reaction time mean	0.9	2.1	3.1	1.8	1.7	1.5	1.4	-1.4	0.3
Reaction time mean AUC	0.7	1.7	2.7	1.6	1.6	1.3	1.3	-1.2	0.2
Median of all reaction times	1.3	2.0	2.4	1.6	1.6	1.5	1.5	-1.5	0.6
Reaction time omissions	0.0	0.0	0.1	-0.1	-0.2	-0.0	-0.0	-0.0	-0.3
Reaction time false alarm rate	0.3	0.5	1.1	-1.1	-1.0	-0.5	-0.5	0.4	0.0
Reaction time premature initiation rate	0.4	0.6	1.0	0.4	0.5	0.7	0.8	-0.9	1.0
Reaction time premature initiations	0.1	0.3	0.4	-0.5	-0.5	-0.6	-0.6	0.6	-0.0
Std. dev. reaction times	0.2	0.8	1.7	1.3	1.2	0.7	0.7	-0.6	-0.4
Reaction time trials completed	1.8	6.0	7.9	-2.2	-2.3	-2.7	-2.7	2.8	-1.9
Reaction time trials AUC	2.1	7.4	9.5	-2.5	-2.5	-3.0	-3.0	3.1	-2.1
Run reversals in cocaine runway, females	0.3	0.3	0.5	0.3	0.3	0.5	0.5	-0.7	0.7
Run reversals in cocaine runway, males	0.4	0.4	0.5	-0.6	-0.6	-0.7	-0.7	0.7	-0.6
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.3	0.3	-0.1	-0.1	-0.1	-0.2
Latency to leave start box in cocaine runway, F	0.3	0.4	0.6	-0.3	-0.2	-0.7	-0.7	0.6	-0.8
Latency to leave start box in cocaine runway, M	0.2	0.1	0.2	0.4	0.4	0.3	0.4	-0.5	0.4
Std. dev. time between licks in bursts	0.0	0.1	0.2	-0.4	-0.4	-0.2	-0.2	0.1	0.0
Total sessions with >9 infusions	3.6	4.5	5.1	-2.2	-2.2	-2.2	-2.2	2.1	-1.6
Short access day 1 total inactive lever presses	0.9	1.7	4.1	-2.0	-1.9	-1.0	-1.0	0.8	0.2
Short access day 10 total inactive lever presses	0.2	1.1	1.4	1.1	1.1	1.2	1.2	-1.1	0.8
Short access day 1 total infusions	1.4	2.8	3.3	-1.8	-1.8	-1.7	-1.7	1.7	-1.3
Short access day 10 total infusions	2.9	4.7	6.1	-2.5	-2.4	-2.2	-2.2	2.1	-1.4
Short access total infusions	2.3	3.2	4.3	-2.1	-2.1	-1.8	-1.8	1.7	-1.1
Short access day 1 locomotion	2.7	4.5	6.4	-2.5	-2.5	-2.1	-2.1	2.0	-1.1
Short access day 10 total locomotion	0.0	0.0	0.0	0.2	0.1	-0.0	-0.0	0.1	-0.2
Short access total locomotion	0.6	1.0	1.4	-1.2	-1.2	-1.0	-1.0	0.9	-0.5
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.4	-0.4	-0.2	-0.2	0.2	-0.1
Compulsive drug intake	0.1	0.1	0.2	-0.1	-0.1	-0.4	-0.4	0.4	-0.5
One hour access (shock baseline)	0.6	1.6	2.3	-1.5	-1.5	-1.2	-1.2	1.1	-0.8
Social response proportion	0.6	0.8	1.0	-0.8	-0.8	-1.0	-1.0	0.9	-0.6
Social responses	0.7	0.9	1.1	-1.0	-1.0	-1.0	-1.0	0.9	-0.5
Social time	2.7	4.3	5.5	1.7	1.8	2.1	2.2	-2.4	2.1
Soleus weight	0.1	0.3	0.4	-0.7	-0.7	-0.6	-0.6	0.5	-0.3
Bone: stiffness	0.6	1.1	1.5	-1.2	-1.2	-1.1	-1.1	1.1	-0.5
Tibialis anterior weight	3.0	10.4	12.8	-3.6	-3.6	-3.4	-3.4	3.3	-1.8
Time to tail flick, vehicle, before self-admin	2.1	2.6	3.3	-1.5	-1.6	-1.8	-1.8	1.8	-1.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	0.6	0.6	0.0	-0.0	0.0	-0.4
Time to tail flick, test, before self-admin	0.2	0.3	0.4	0.6	0.5	0.6	0.6	-0.5	-0.2
Time to tail flick, test, after self-admin	0.2	0.2	0.7	-0.0	0.1	0.3	0.3	-0.5	0.8
Delta time to tail flick, vehicle, before/after SA	0.2	0.3	0.6	0.7	0.7	0.4	0.4	-0.4	-0.0
Delta time to tail flick, test, before/after SA	0.6	0.7	1.1	-1.1	-1.0	-1.0	-0.9	0.8	0.1
Tibia length	0.3	0.9	1.6	-1.3	-1.2	-0.8	-0.8	0.8	-0.6
Ambulatory time before self-admin	0.0	0.0	0.1	0.2	0.2	0.1	0.1	-0.0	0.2
Ambulatory time after self-admin	0.4	0.7	1.1	1.0	1.0	0.7	0.7	-0.7	0.8
Bone: tissue strength	0.8	0.8	1.0	0.9	0.9	0.9	0.9	-1.0	0.7
Total heroin consumption	0.0	0.0	0.1	-0.2	-0.2	0.0	0.0	-0.0	0.3
Bone: trabecular number	0.0	0.0	0.0	0.1	0.1	0.2	0.2	-0.1	0.2
Bone: trabecular spacing	0.0	0.0	0.0	-0.1	-0.0	-0.2	-0.2	0.1	-0.1
Bone: trabecular thickness	1.3	1.8	2.3	-1.4	-1.4	-1.4	-1.4	1.5	-1.0
Bone: trabecular tissue density	0.2	0.4	0.5	-0.6	-0.6	-0.7	-0.7	0.7	-0.6
Water consumed over 24 hours	0.1	0.2	0.4	0.7	0.6	0.4	0.4	-0.5	0.1
Number of responses in last shaping day	2.5	3.2	4.3	-1.5	-1.6	-1.8	-1.8	1.8	-2.1