Hub : Genes

Ptk7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Ptk7	0.19	0.09	0.0e+00	0.18	0.18	0.18	0.18	2.7e-19	1.2e-19	2.4e-19	2.8e-19
2	Brain	gene expression	Ptk7	0.23	0.1	0.0e+00	0.26	0.24	0.25	0.26	1.7e-24	1.1e-22	7.1e-23	2.7e-24
3	Brain	mRNA stability	Ptk7	0.09	0.06	1.8e-05	0.03	0.03	0.04	0.04	6.9e-04	5.6e-04	6.9e-05	8.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.9	1.5	3.3	-0.9	0.7	-1.8
Area under the delay curve	5.4	5.7	9.2	-2.8	3.0	0.2
BMI with tail	3.7	12.0	15.6	3.9	-3.7	2.7
BMI without tail	10.2	21.0	29.0	5.4	-5.0	2.9
Body weight	2.2	9.4	13.7	3.7	-3.5	1.4
Weight adjusted by age	0.2	0.2	0.3	0.5	-0.6	0.2
Bone surface	1.8	3.2	4.1	-1.7	1.6	-2.0
Bone volume	0.8	1.4	2.1	-1.1	1.0	-1.4
Breakpoint value in progressive ratio session	0.1	0.1	0.4	0.0	0.1	0.6
Number of licking bursts	2.5	2.9	4.8	1.8	-2.2	-0.8
Context. condit. distance diff. score	0.1	0.1	0.1	0.4	-0.4	-0.3
Locomotion velocity, session 1	1.4	1.6	3.2	1.0	-0.7	1.8
Locomotion distance, session 1	1.7	2.2	3.3	1.8	-1.7	0.7
Locomotion velocity, session 2	5.2	6.1	8.0	2.8	-2.6	1.9
Locomotion distance, session 2	1.3	1.9	2.4	1.6	-1.4	1.1
Locomotion velocity, session 3	1.3	1.5	3.1	1.0	-0.7	1.8
Locomotion distance, session 3	0.5	0.6	1.0	-0.7	1.0	0.5
Stereotopy head waving bouts, day 3	1.1	1.2	1.6	1.3	-1.3	0.7
Stereotopy head waving duration, day 3	2.2	2.6	2.9	1.7	-1.6	1.5
Locomotion velocity, session 7	0.8	0.9	2.2	0.7	-0.3	1.5
Locomotion distance, session 7	0.6	0.8	2.1	0.5	-0.1	1.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.4	-0.5	-0.1
Stereotopy head waving duration, day 7	0.3	0.3	0.8	-0.3	0.1	-0.9
Locomotion velocity, session 8	0.6	0.7	0.9	0.9	-0.9	0.6
Locomotion distance, session 8	0.7	1.1	1.7	1.3	-1.1	0.6
Degree of sensitization distance	1.8	1.8	2.2	1.5	-1.3	1.2
Degree of sensitization stereotypy	0.6	0.6	0.8	-0.8	0.7	-0.9
Conditioned locomotion	1.4	1.6	2.6	-1.2	1.6	0.9
Cocaine response after cond. corrected	0.2	0.2	0.3	-0.6	0.5	-0.0
Cocaine response after cond. not corrected	0.3	0.3	0.5	-0.7	0.6	0.2
Cocaine response before conditioning	0.2	0.3	0.7	0.3	-0.2	0.8
Saline control response	0.0	0.0	0.1	0.0	0.1	0.3
Bone: connectivity density	2.1	3.3	6.8	-1.4	1.0	-2.6
Bone: cortical apparent density	0.5	0.7	0.9	-0.9	1.0	-0.4
Bone: cortical area	0.7	1.1	1.4	1.2	-0.8	1.2
Bone: cortical porosity	0.1	0.1	0.1	0.3	-0.3	-0.2
Bone: cortical porosity	0.1	0.1	0.2	0.3	-0.2	0.5
Bone: cortical thickness	1.0	1.6	2.1	1.5	-1.1	1.2
Bone: cortical thickness	0.1	0.1	0.2	-0.1	0.1	-0.4
Bone: cortical tissue density	0.4	0.6	0.8	-0.9	0.9	-0.4
Condit. Reinf. active minus inactive responses	1.4	1.6	2.2	1.4	-1.5	0.7
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.5	-0.6	-0.1
Condit. Reinf. active responses	2.2	2.6	3.9	1.9	-2.0	0.5
Condit. Reinf. inactive responses	1.6	1.9	2.9	1.7	-1.7	0.2
Incentive salience index mean	2.1	2.5	3.3	1.8	-1.7	1.2
Condit. Reinf. lever presses	3.4	4.5	6.4	2.5	-2.3	1.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.1	-0.3	-0.8
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.3	0.6	-1.1	-0.9
Condit. Reinf. active responses	0.0	0.0	0.1	-0.1	-0.1	-0.3
Condit. Reinf. inactive responses	0.2	0.2	0.5	-0.0	0.3	0.7
Condit. Reinf. lever presses	0.4	0.5	0.6	0.7	-0.8	-0.6
Condit. Reinf. lever reinforcers received	0.0	0.1	0.1	-0.2	-0.1	-0.4
Conditioned reinforcement - actives	0.9	0.9	1.1	-0.7	1.0	1.1
Conditioned reinforcement - inactives	1.3	1.5	2.6	1.1	-0.8	1.6
Conditioned locomotion	0.0	0.0	0.0	0.1	0.0	0.2
Patch foraging indifference point 0 sec	0.6	0.9	1.3	1.1	-1.1	0.4
Patch foraging indifference point AUC	2.3	2.6	5.5	1.3	-0.9	2.3
Delay disc. indifference point, 0s delay	1.1	1.2	1.4	-1.2	1.2	0.9
Delay disc. indifference point, 16s delay	7.9	8.0	12.4	-3.4	3.5	-0.5
Delay disc. indifference point, 2s delay	2.0	2.2	3.1	-1.7	1.7	0.7
Delay disc. indifference point, 24s delay	1.0	1.0	1.4	-1.2	1.0	-0.8
Delay disc. indifference point, 4s delay	2.7	2.9	3.7	-1.3	1.9	1.8
Delay disc. indifference point, 8s delay	3.3	3.4	5.6	-2.1	2.4	0.4
Indifference point function ln k	0.3	0.4	0.7	-0.8	0.8	0.2
Indifference point function log k	0.3	0.4	0.7	-0.8	0.8	0.2
Patch foraging total patch changes 0 sec	0.8	1.3	1.8	1.3	-1.3	0.7
Patch foraging total patch changes 12 sec	1.5	2.0	2.9	1.4	-1.0	1.7
Patch foraging total patch changes 18 sec	2.1	2.7	3.8	1.6	-1.3	1.9
Patch foraging total patch changes 24 sec	1.0	1.3	1.5	1.2	-0.9	1.2
Patch foraging total patch changes 6 sec	1.8	2.6	3.7	1.9	-1.8	1.0
Patch foraging time to switch 0 sec	5.8	9.0	10.7	-3.0	2.7	-3.3
Patch foraging water rate 0 sec	5.5	8.8	16.5	2.6	-1.8	4.1
Patch foraging water rate 12 sec	5.3	8.1	10.2	3.2	-2.7	2.6
Patch foraging water rate 18 sec	1.5	2.0	2.5	1.5	-1.2	1.6
Patch foraging water rate 24 sec	2.5	3.5	4.5	1.9	-1.6	2.1
Patch foraging water rate 6 sec	1.4	2.1	5.4	0.8	-0.4	2.3
Seeking ratio, delayed vs. immediate footshock	1.8	2.1	2.9	-1.7	1.7	-0.7
Distance traveled before self-admin	0.2	0.2	0.5	0.5	0.0	0.7
Distance traveled after self-admin	2.9	3.3	4.7	2.2	-2.0	1.0
Extensor digitorum longus weight	0.1	0.4	0.4	0.7	-0.5	0.7
Bone: elastic displacement	0.2	0.2	0.4	-0.6	0.5	-0.2
Bone: elastic work	0.1	0.1	0.4	0.1	-0.2	-0.6
Bone: endosteal estimation	0.3	0.8	1.2	-1.0	1.1	-0.2
Bone: endosteal perimeter	0.0	0.0	0.0	0.0	0.1	0.1
Epididymis fat weight	1.4	3.1	5.1	2.0	-2.3	-0.5
Delta time in closed arm before/after self-admin	0.2	0.2	0.6	0.2	-0.3	-0.8
Delta time in open arm before/after self-admin	0.4	0.3	0.4	-0.5	0.6	0.7
Diff in mean of infusions in LGA sessions	0.8	0.9	1.8	0.8	-0.6	1.3
Delay discount exponential model param	5.2	5.5	8.8	2.8	-3.0	-0.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.1	-0.0	0.4
Active lever presses in extinction session 6	0.6	0.6	1.6	0.4	-0.2	1.3
Bone: final force	0.3	0.4	0.7	0.9	-0.6	0.4
Bone: final moment	0.4	0.7	0.8	0.9	-0.6	0.9
Food consumed during 24 hour testing period	1.0	1.2	1.7	1.0	-0.9	1.3
Glucose	3.6	5.4	8.5	2.7	-2.9	0.4
Heart weight	0.9	1.3	2.2	-1.3	1.5	0.3
Delay discount hyperbolic model param	4.6	4.9	7.9	2.6	-2.8	-0.4
Intermittent access intake day 1-15 change	0.2	0.2	0.5	0.3	-0.1	0.7
Intermittent access intake escalation	0.0	0.0	0.0	0.0	0.1	0.1
Intermittent access intake escalation 2	0.3	0.3	0.7	0.4	-0.2	0.9
Intermitt. access day 1 inactive lever presses	1.2	1.2	1.7	1.3	-1.3	0.6
Intermitt. access day 15 inactive lever presses	1.5	1.7	2.3	1.5	-1.4	0.8
Intermitt. access escalation Index	0.0	0.0	0.1	-0.1	0.1	-0.2
Intermittent access day 1 total infusions	0.4	0.4	0.7	0.7	-0.8	-0.4
Intermittent access day 15 total infusions	0.2	0.2	0.3	0.5	-0.5	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.3	-0.3	-0.5
Intermittent access total infusions	0.2	0.2	0.4	0.2	-0.3	-0.7
Intermittent access day 1 locomotion	0.3	0.3	0.5	0.3	-0.5	-0.7
Intermittent access day 15 total locomotion	0.2	0.2	0.4	0.6	-0.5	0.1
Intermittent access total locomotion	0.4	0.4	1.3	-0.1	-0.1	-1.1
Intermittent access standard deviation	3.4	3.6	4.2	-2.1	1.9	-1.8
Left kidney weight	0.5	1.4	3.0	1.0	-0.5	1.7
Right kidney weight	0.5	1.5	4.2	0.5	0.1	2.0
Cocaine induced anxiety	0.2	0.2	0.4	0.2	-0.4	-0.6
Post-drug Anxiety	0.4	0.5	1.3	-0.2	-0.1	-1.2
Baseline Anxiety	0.2	0.2	0.3	-0.5	0.5	-0.1
Tail length	1.2	3.8	5.8	2.4	-2.3	0.3
Length with tail	0.1	0.2	0.3	0.5	-0.4	-0.6
Length without tail	2.3	5.0	6.6	-2.6	2.4	-1.6
Times rat made contact with spout	3.5	4.0	6.7	2.3	-2.6	0.2
Lifetime Intake	0.1	0.1	0.2	-0.3	0.3	-0.5
Liver weight, left	0.7	1.1	1.9	0.9	-0.7	1.4
Liver weight, right	0.4	0.7	1.0	1.0	-1.0	0.2
Locomotor activity	1.7	2.7	4.6	1.8	-2.2	-0.5
Locomotor testing distance	1.4	2.4	4.0	1.6	-2.0	-0.7
Locomotor testing rearing	3.1	4.8	6.0	2.4	-2.5	1.5
Locomotion in novel chamber	0.6	0.7	1.2	-0.9	1.1	0.1
Locomotion in novel chamber post-restriction	1.2	1.4	1.9	-0.9	1.4	1.3
Fecal boli incidents, locomotor time 1	1.1	1.2	2.9	-0.3	0.8	1.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.1	0.2	0.5
Time >=10cm from walls, locomotor time 1	0.9	1.0	2.2	0.7	-0.4	1.5
Bouts of movement, locomotor time 1	0.1	0.2	0.2	-0.4	0.3	-0.5
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.2	-0.2	-0.2
Rest time, locomotor task time 1	0.7	0.7	1.0	-0.8	1.0	0.8
Distance moved, locomotor task time 1	0.3	0.3	0.8	0.1	-0.3	-0.9
Vertical activity count, locomotor time 1	0.5	0.6	0.7	-0.8	0.7	-0.7
Time >=10cm from walls, locomotor time 2	1.1	1.1	2.2	1.0	-0.5	1.5
Bouts of movement, locomotor time 2	0.2	0.3	0.4	0.6	-0.6	-0.3
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.2	-0.3	-0.6
Rest time, locomotor task time 2	0.6	0.7	1.0	-1.0	1.0	-0.3
Distance moved, locomotor task time 2	0.8	0.9	1.5	1.1	-1.2	0.0
Vertical activity count, locomotor time 2	0.1	0.1	0.1	-0.2	0.3	0.3
Light reinforcement 1	1.9	3.4	4.4	2.1	-2.0	1.4
Light reinforcement 2	1.6	2.2	3.2	1.7	-1.8	-0.5
Bone: marrow area	0.4	0.9	1.3	-1.1	1.2	-0.2
Bone: maximum diameter	0.4	0.8	1.7	0.8	-0.4	1.3
Bone: maximum force	0.1	0.1	0.3	0.1	-0.0	-0.6
Bone: maximum moment	0.0	0.0	0.0	0.1	0.1	-0.0
Mean time between licks in bursts	1.9	2.6	2.8	-1.7	1.6	-1.6
Mean num. licks in bursts	0.4	0.5	0.6	-0.6	0.8	0.8
Cd content in liver	0.7	0.8	1.2	-0.9	1.1	0.6
Co content in liver	0.0	0.0	0.0	0.2	-0.2	0.2
Cu content in liver	0.6	0.7	1.3	-0.5	0.8	1.1
Fe content in liver	0.5	0.6	0.7	-0.7	0.8	-0.7
K content in liver	2.3	2.2	5.4	-1.0	0.6	-2.3
Mg content in liver	1.6	1.7	2.2	-1.5	1.5	-0.7
Mn content in liver	0.6	0.6	1.1	0.9	-1.0	0.2
Na content in liver	0.1	0.1	0.1	0.3	-0.2	0.3
Rb content in liver	4.8	6.0	8.9	-2.9	3.0	-0.9
Se content in liver	0.2	0.3	0.4	0.5	-0.4	0.6
Sr content in liver	0.9	0.8	0.9	0.9	-0.9	0.9
Zn content in liver	3.3	3.7	5.7	-2.0	2.4	1.2
Bone: minimum diameter	0.2	0.4	0.6	0.8	-0.4	0.7
Time in familiar zone, hab. session 1	1.5	1.4	2.7	1.0	-0.7	1.6
Time in novel zone, hab. session 1	0.9	0.9	1.2	-1.1	0.9	-0.9
Total zone transitions, hab. session 1	3.1	4.3	6.5	2.6	-2.4	0.9
Total locomotion distance, hab. session 1	4.0	5.7	7.6	2.8	-2.5	1.8
Locomotion velocity, hab. session 1	3.6	5.1	6.8	2.6	-2.3	1.8
Time in familiar zone, hab. session 2	2.6	2.6	2.9	-1.6	1.5	-1.7
Time in novel zone, hab. session 2	0.9	0.9	1.7	0.7	-0.6	1.3
Total zone transitions, hab. session 2	1.9	2.5	3.9	1.7	-2.0	-0.9
Total locomotion distance, hab. session 2	2.1	2.7	4.2	2.0	-2.1	0.1
Locomotion velocity, hab. session 2	1.6	2.2	3.5	1.7	-1.9	-0.1
Novel to familiar place preference ratio	0.1	0.1	0.1	0.3	-0.3	0.2
Novelty place preference	0.0	0.0	0.0	0.1	-0.1	0.1
Time in novel zone, NPP test	0.0	0.0	0.1	0.1	-0.0	0.2
Total zone transitions, NPP test	4.7	6.7	10.1	3.2	-3.1	0.5
Total locomotion distance, NPP test	4.2	5.8	8.6	2.9	-2.9	0.5
Locomotion velocity, NPP test	4.4	6.3	9.6	3.0	-3.1	0.2
Intraocular pressure	0.6	0.8	1.2	-1.1	1.1	0.1
Delta distance traveled before/after self-admin	3.6	3.9	6.7	2.2	-2.6	0.3
Delta ambulatory time before/after self-admin	3.0	3.3	5.8	2.0	-2.4	0.3
Parametrial fat weight	4.3	8.4	12.7	3.5	-3.6	0.6
Pavlov. Cond. lever latency	2.5	3.2	4.2	-2.0	1.6	-1.7
Pavlov. Cond. magazine entry latency	1.6	2.1	4.0	1.2	-0.8	2.0
Pavlov. Cond. change in total contacts	2.1	2.3	2.9	1.7	-1.3	1.5
Pavlov. Cond. index score	3.1	3.9	4.6	2.1	-1.7	2.1
Pavlov. Cond. latency score	2.4	3.1	4.2	1.8	-1.3	2.0
Pavlov. Cond. lever contacts	3.4	4.0	5.3	2.3	-1.9	1.8
Pavlov. Cond. magazine entry number	2.3	2.9	3.5	-1.8	1.4	-1.9
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.2	-1.1	1.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	3.1	3.8	4.6	2.1	-1.6	2.1
Pavlov. Cond. response bias	4.2	5.1	6.6	2.6	-2.2	2.0
Pavlov. Cond. lever latency	1.5	2.1	3.0	-1.7	1.7	0.6
Pavlov. Cond. magazine entry latency	1.0	1.2	1.9	1.4	-1.3	-0.2
Pavlov. Cond. change in total contacts	1.6	2.1	3.4	1.7	-1.9	-0.5
Pavlov. Cond. index score	2.7	3.5	5.4	2.3	-2.3	-0.2
Pavlov. Cond. latency score	3.0	3.7	5.7	2.4	-2.3	-0.3
Pavlov. Cond. lever contacts	1.6	2.2	3.3	1.8	-1.8	-0.5
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	-0.9	0.8	0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.0	-0.1	0.2
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.4	5.2	2.3	-2.2	-0.3
Pavlov. Cond. response bias	0.6	0.8	0.9	1.0	-0.9	-0.8
Time in closed arm before self-admin	0.5	0.6	1.2	-0.6	0.2	-1.1
Time in closed arm after self-admin	1.0	1.1	3.0	-0.4	-0.1	-1.7
Time in open arm before self-admin	2.6	2.8	3.8	2.0	-1.4	1.6
Time in open arm after self-admin	1.4	1.5	3.3	1.0	-0.6	1.8
Bone: periosteal estimation	0.2	0.4	1.0	0.4	-0.0	1.0
Bone: periosteal perimeter	0.4	0.7	1.2	1.1	-0.8	0.5
Bone: post-yield work	0.2	0.2	0.7	-0.1	0.1	-0.8
Progressive ratio test 1 active lever presses	0.8	0.8	1.2	0.9	-1.1	-0.6
Progressive ratio test 1 breakpoint	0.6	0.6	1.0	0.9	-1.0	-0.3
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.3	1.1	-1.0	0.9
Progressive ratio test 2 active lever presses	1.1	1.2	1.6	1.3	-1.0	1.0
Progressive ratio test 2 breakpoint	1.6	1.8	2.5	1.6	-1.3	1.2
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.7	0.9	-0.7	0.7
Incentive Sensitization - Responses	1.3	1.3	1.6	1.3	-0.9	1.2
Incentive Sensitization - Breakpoint	1.3	1.3	1.7	1.3	-1.0	1.2
Sum of active levers in priming session hrs 5-6	1.2	1.2	2.2	-0.6	1.0	1.5
Progressive ratio	0.4	0.5	0.7	-0.8	0.8	-0.4
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.1	-0.2	-0.3
Seeking ratio, punishment vs. effort	0.4	0.5	0.7	0.8	-0.9	0.4
Retroperitoneal fat weight	1.9	6.1	7.0	2.6	-2.3	2.5
Reaction time number correct	0.9	1.4	3.8	0.0	0.5	2.0
Reaction time mean minus median	0.2	0.3	0.6	-0.4	0.2	-0.8
Reaction time mean minus median AUC	0.6	0.8	1.6	-0.9	0.5	-1.2
Reaction time num false alarms	0.6	0.8	1.0	-1.0	1.0	-0.6
Reaction time num false alarms AUC	0.3	0.5	0.7	-0.8	0.8	-0.2
Reaction time trials correct on left	0.9	1.4	3.8	0.0	0.5	2.0
Reaction time trials on left	0.9	1.2	3.5	0.1	0.4	1.9
Reaction time mean	1.9	2.7	7.5	-0.7	0.2	-2.7
Reaction time mean AUC	2.2	2.9	8.2	-0.7	0.2	-2.9
Median of all reaction times	1.9	2.6	7.4	-0.6	0.1	-2.7
Reaction time omissions	0.3	0.5	0.7	0.7	-0.9	-0.4
Reaction time false alarm rate	0.9	1.3	2.0	-1.1	0.8	-1.4
Reaction time premature initiation rate	0.8	1.0	1.5	1.2	-1.2	0.5
Reaction time premature initiations	1.3	1.9	2.9	1.3	-1.0	1.7
Std. dev. reaction times	1.3	1.8	4.9	-0.7	0.3	-2.2
Reaction time trials completed	0.9	1.2	3.5	0.1	0.4	1.9
Reaction time trials AUC	0.9	1.4	4.0	0.2	0.3	2.0
Run reversals in cocaine runway, females	0.9	0.8	1.1	1.0	-0.7	1.0
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.3	-0.1	0.5
Latency to leave start box in cocaine runway	1.9	2.0	2.6	1.6	-1.3	1.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.5	-0.4	0.3
Latency to leave start box in cocaine runway, M	4.7	4.5	5.9	2.4	-2.1	1.7
Std. dev. time between licks in bursts	1.4	1.7	3.0	-1.4	1.7	-0.2
Total sessions with >9 infusions	0.1	0.1	0.2	0.0	0.2	0.5
Short access day 1 total inactive lever presses	0.5	0.6	1.6	0.4	-0.1	1.2
Short access day 10 total inactive lever presses	1.3	1.4	2.1	1.2	-0.9	1.4
Short access day 1 total infusions	0.3	0.3	0.5	-0.5	0.7	0.4
Short access day 10 total infusions	0.3	0.4	1.1	-0.2	-0.0	-1.0
Short access total infusions	0.4	0.4	0.5	-0.7	0.7	-0.6
Short access day 1 locomotion	0.5	0.5	0.9	-0.8	0.9	-0.3
Short access day 10 total locomotion	2.8	3.1	3.7	-1.8	1.6	-1.9
Short access total locomotion	1.7	1.8	2.6	-1.6	1.6	-0.4
One hour access (0.3 mA shock)	0.4	0.5	1.1	-0.3	0.6	1.1
Compulsive drug intake	0.5	0.5	1.4	0.0	0.1	1.2
One hour access (shock baseline)	0.1	0.1	0.2	0.4	-0.4	-0.2
Social response proportion	1.2	1.2	1.4	-1.1	1.2	-1.1
Social responses	1.9	2.5	3.4	-1.7	1.8	-1.0
Social time	1.6	2.1	3.4	-0.9	1.5	1.8
Soleus weight	0.3	0.8	1.3	1.1	-1.0	0.2
Bone: stiffness	0.1	0.1	0.2	-0.1	0.2	-0.4
Tibialis anterior weight	0.1	0.4	0.6	0.8	-0.7	0.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.5	0.2	-0.2
Time to tail flick, vehicle, after self-admin	3.9	4.2	6.0	-1.9	1.6	-2.5
Time to tail flick, test, before self-admin	3.2	3.2	5.0	-2.0	2.2	0.6
Time to tail flick, test, after self-admin	0.3	0.3	0.6	-0.8	0.6	-0.2
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.3	-0.9	0.9	-1.2
Delta time to tail flick, test, before/after SA	1.9	1.7	3.2	0.7	-1.2	-1.8
Tibia length	2.2	6.2	8.1	2.8	-2.6	2.0
Ambulatory time before self-admin	0.3	0.3	0.8	0.1	0.4	0.9
Ambulatory time after self-admin	2.8	3.0	4.4	2.1	-2.0	0.9
Bone: tissue strength	0.1	0.1	0.1	-0.2	0.3	0.2
Total heroin consumption	0.0	0.0	0.1	0.2	0.1	-0.2
Bone: trabecular number	0.8	1.2	1.9	-1.0	0.9	-1.4
Bone: trabecular spacing	1.0	1.3	2.4	1.0	-0.8	1.5
Bone: trabecular thickness	1.1	1.4	1.9	-1.1	1.0	-1.4
Bone: trabecular tissue density	1.1	1.6	4.6	0.1	0.3	2.2
Water consumed over 24 hours	2.4	2.9	3.4	1.8	-1.6	1.6
Number of responses in last shaping day	0.4	0.4	0.9	0.5	-0.3	1.0