Hub : Genes

Ptbp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Ptbp1	0.04	0.03	6.2e-03	0.02	0.01	0.02	0.01	3.2e-03	1.2e-02	6.3e-03	7.1e-03
2	Liver	alternative polyA	NM_022516.5	0.05	0.04	9.1e-03	0.01	0.01	0.02	0.01	3.3e-02	1.8e-02	4.5e-03	1.7e-02
3	NAcc	intron excision ratio	chr7_9844539_9844945	0.01	0.01	7.4e-03	0.01	0.01	0.01	0.01	2.2e-02	1.8e-02	4.7e-02	2.2e-02
4	Adipose	alternative polyA	NM_022516.5	0.06	0.04	7.2e-03	0.02	0.01	0.02	0.02	1.7e-03	7.9e-03	5.4e-03	2.7e-03
5	Adipose	alternative polyA	XM_039078591.1	0.06	0.04	7.0e-03	0.02	0.01	0.02	0.02	1.6e-03	7.0e-03	5.0e-03	2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	2.2	3.7	5.9	-1.0	-2.3	-0.5	-2.4	2.4
Area under the delay curve	1.1	1.2	2.8	1.6	0.7	-1.7	0.2	-0.2
BMI with tail	3.4	10.9	23.0	4.8	2.5	-4.7	1.1	-1.1
BMI without tail	2.6	5.4	9.0	3.0	2.5	-2.1	1.9	-1.9
Body weight	0.7	2.8	6.1	2.5	1.3	-2.3	0.7	-0.7
Weight adjusted by age	1.6	1.8	2.7	1.2	1.6	-0.6	1.5	-1.5
Bone surface	4.5	7.9	12.0	-2.0	-3.4	0.0	-3.5	3.5
Bone volume	4.4	7.4	11.4	-1.9	-3.3	-0.1	-3.4	3.4
Breakpoint value in progressive ratio session	2.1	2.4	6.8	-2.1	-0.4	2.6	0.4	-0.4
Number of licking bursts	1.0	1.2	1.9	0.7	1.4	-0.1	1.3	-1.3
Context. condit. distance diff. score	0.3	0.3	0.6	0.8	0.5	-0.2	0.5	-0.5
Locomotion velocity, session 1	1.6	1.8	2.5	-1.3	-1.6	0.6	-1.5	1.5
Locomotion distance, session 1	4.0	5.1	8.1	-1.4	-2.8	0.4	-2.8	2.8
Locomotion velocity, session 2	6.6	7.7	10.3	-3.0	-3.2	2.3	-2.6	2.6
Locomotion distance, session 2	5.6	7.8	11.3	-2.6	-3.4	1.2	-3.1	3.1
Locomotion velocity, session 3	2.8	3.2	9.3	-2.5	-0.7	3.0	0.1	-0.1
Locomotion distance, session 3	0.2	0.2	0.3	0.3	0.4	0.2	0.6	-0.6
Stereotopy head waving bouts, day 3	3.8	4.4	7.6	-2.7	-2.0	2.8	-1.3	1.3
Stereotopy head waving duration, day 3	3.5	4.2	8.8	-2.8	-1.6	3.0	-0.9	0.9
Locomotion velocity, session 7	0.3	0.3	1.1	-0.4	0.0	1.0	0.4	-0.4
Locomotion distance, session 7	1.2	1.5	2.2	1.0	1.4	-0.2	1.5	-1.5
Stereotopy head waving bouts, day 7	1.0	1.2	1.9	-0.6	-1.4	0.2	-1.3	1.3
Stereotopy head waving duration, day 7	1.5	1.8	2.7	-1.0	-1.6	0.4	-1.6	1.6
Locomotion velocity, session 8	3.2	3.8	5.9	-1.6	-2.4	0.9	-2.2	2.2
Locomotion distance, session 8	0.7	1.1	1.7	-0.8	-1.3	0.6	-1.2	1.2
Degree of sensitization distance	0.2	0.2	0.4	0.6	0.2	-0.6	0.1	-0.1
Degree of sensitization stereotypy	0.8	0.9	2.3	1.0	-0.3	-1.5	-0.8	0.8
Conditioned locomotion	2.3	2.7	3.5	1.9	1.9	-1.2	1.6	-1.6
Cocaine response after cond. corrected	6.8	7.6	11.3	3.4	3.1	-2.5	2.4	-2.4
Cocaine response after cond. not corrected	7.4	8.1	11.8	3.4	3.2	-2.5	2.5	-2.5
Cocaine response before conditioning	0.4	0.4	0.8	-0.8	-0.6	0.9	-0.3	0.3
Saline control response	0.0	0.0	0.1	0.3	0.2	-0.2	0.2	-0.2
Bone: connectivity density	1.2	1.9	3.1	-0.3	-1.6	-0.8	-1.8	1.8
Bone: cortical apparent density	0.4	0.6	1.6	0.9	0.6	-1.3	0.1	-0.1
Bone: cortical area	0.4	0.6	1.0	0.5	-0.5	-1.0	-0.8	0.8
Bone: cortical porosity	0.9	1.0	1.4	-1.0	-1.2	0.6	-1.0	1.0
Bone: cortical porosity	1.4	1.5	2.3	-0.7	-1.5	0.0	-1.5	1.5
Bone: cortical thickness	0.5	0.8	2.3	1.0	-0.1	-1.5	-0.5	0.5
Bone: cortical thickness	1.0	1.2	1.8	0.6	1.3	-0.0	1.3	-1.3
Bone: cortical tissue density	0.3	0.4	1.2	0.7	0.6	-1.1	0.2	-0.2
Condit. Reinf. active minus inactive responses	2.2	2.5	6.3	-2.2	-1.1	2.5	-0.3	0.3
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.6	-1.1	0.3	1.6	0.7	-0.7
Condit. Reinf. active responses	3.6	4.5	7.0	-2.7	-2.2	2.3	-1.6	1.6
Condit. Reinf. inactive responses	3.2	3.8	5.8	-1.8	-2.4	1.0	-2.1	2.1
Incentive salience index mean	2.4	2.9	4.2	-2.0	-1.8	1.9	-1.3	1.3
Condit. Reinf. lever presses	3.0	4.0	6.3	-1.1	-2.5	0.0	-2.5	2.5
Condit. Reinf. active minus inactive responses	1.0	1.2	2.4	-1.1	0.6	1.5	1.0	-1.0
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.7	0.3	1.3	-0.0	1.3	-1.3
Condit. Reinf. active responses	0.7	1.0	2.6	-1.3	0.2	1.6	0.6	-0.6
Condit. Reinf. inactive responses	0.4	0.5	1.7	-1.0	-0.2	1.3	0.1	-0.1
Condit. Reinf. lever presses	0.9	1.2	3.1	-1.2	0.3	1.7	0.9	-0.9
Condit. Reinf. lever reinforcers received	0.7	1.0	1.9	-0.9	0.6	1.4	1.0	-1.0
Conditioned reinforcement - actives	0.9	0.9	2.0	-1.4	-0.6	1.4	-0.1	0.1
Conditioned reinforcement - inactives	0.8	0.9	1.1	1.1	1.0	-0.6	0.9	-0.9
Conditioned locomotion	3.0	3.6	8.6	-2.8	-1.2	2.9	-0.2	0.2
Patch foraging indifference point 0 sec	0.1	0.2	0.3	0.3	-0.2	-0.6	-0.4	0.4
Patch foraging indifference point AUC	0.3	0.3	0.8	-0.8	-0.2	0.9	0.0	-0.0
Delay disc. indifference point, 0s delay	3.8	4.1	9.0	1.7	-1.0	-3.0	-1.9	1.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	0.3	-0.4	0.1	-0.1
Delay disc. indifference point, 2s delay	2.2	2.4	6.9	2.1	0.2	-2.6	-0.6	0.6
Delay disc. indifference point, 24s delay	0.7	0.7	1.2	1.1	0.9	-1.0	0.5	-0.5
Delay disc. indifference point, 4s delay	0.3	0.4	1.0	0.8	0.1	-1.0	-0.2	0.2
Delay disc. indifference point, 8s delay	1.5	1.5	2.6	1.6	1.3	-1.2	1.0	-1.0
Indifference point function ln k	0.3	0.4	0.7	0.8	0.7	-0.6	0.6	-0.6
Indifference point function log k	0.3	0.4	0.7	0.8	0.7	-0.6	0.6	-0.6
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	0.3	-0.1	-0.4	-0.2	0.2
Patch foraging total patch changes 12 sec	0.5	0.6	0.9	0.9	0.8	-0.7	0.7	-0.7
Patch foraging total patch changes 18 sec	0.5	0.6	1.4	-1.2	-0.5	1.2	-0.2	0.2
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	-0.4	-0.3	0.1	-0.3	0.3
Patch foraging total patch changes 6 sec	0.2	0.3	0.5	-0.7	-0.5	0.4	-0.5	0.5
Patch foraging time to switch 0 sec	1.6	2.5	4.1	0.2	-1.7	-1.2	-2.0	2.0
Patch foraging water rate 0 sec	2.2	3.5	5.5	1.1	2.3	0.1	2.3	-2.3
Patch foraging water rate 12 sec	3.2	4.8	7.1	2.2	2.7	-1.2	2.3	-2.3
Patch foraging water rate 18 sec	5.0	6.7	11.0	1.3	3.2	0.3	3.3	-3.3
Patch foraging water rate 24 sec	5.1	7.1	10.7	2.0	3.3	-0.5	3.2	-3.2
Patch foraging water rate 6 sec	2.0	2.9	4.9	0.5	2.0	0.6	2.2	-2.2
Seeking ratio, delayed vs. immediate footshock	2.4	2.8	5.8	-2.4	-1.4	2.2	-0.8	0.8
Distance traveled before self-admin	0.3	0.3	0.8	0.5	-0.2	-0.9	-0.6	0.6
Distance traveled after self-admin	0.4	0.5	0.8	-0.9	-0.7	0.7	-0.6	0.6
Extensor digitorum longus weight	3.1	12.1	24.1	4.9	3.2	-4.1	2.2	-2.2
Bone: elastic displacement	0.1	0.2	0.4	-0.6	-0.3	0.2	-0.3	0.3
Bone: elastic work	0.1	0.2	0.6	0.5	0.1	-0.8	-0.2	0.2
Bone: endosteal estimation	0.1	0.1	0.2	0.4	-0.1	-0.5	-0.3	0.3
Bone: endosteal perimeter	0.3	0.7	0.9	-0.9	-1.0	0.7	-0.8	0.8
Epididymis fat weight	0.1	0.3	0.8	-0.6	0.0	0.9	0.3	-0.3
Delta time in closed arm before/after self-admin	4.6	4.5	6.8	1.8	2.6	-0.7	2.4	-2.4
Delta time in open arm before/after self-admin	0.5	0.5	1.4	0.8	-0.1	-1.2	-0.4	0.4
Diff in mean of infusions in LGA sessions	1.0	1.1	2.5	-1.5	-0.6	1.6	-0.2	0.2
Delay discount exponential model param	1.1	1.2	2.5	-1.6	-0.8	1.6	-0.3	0.3
Extinction: sum of active levers before priming	0.6	0.6	1.4	-0.6	0.4	1.2	0.7	-0.7
Active lever presses in extinction session 6	1.3	1.3	2.7	-1.6	-0.9	1.5	-0.6	0.6
Bone: final force	0.5	0.8	2.2	1.2	-0.1	-1.5	-0.5	0.5
Bone: final moment	0.4	0.7	1.8	1.0	-0.1	-1.3	-0.5	0.5
Food consumed during 24 hour testing period	0.5	0.6	1.1	1.1	0.9	-0.8	0.5	-0.5
Glucose	0.9	1.3	2.7	1.6	0.9	-1.6	0.4	-0.4
Heart weight	0.3	0.5	0.8	-0.2	0.7	0.5	0.9	-0.9
Delay discount hyperbolic model param	1.4	1.5	3.5	-1.8	-0.8	1.9	-0.2	0.2
Intermittent access intake day 1-15 change	2.6	2.5	7.3	-2.2	-0.6	2.7	0.2	-0.2
Intermittent access intake escalation	2.5	2.4	6.9	-1.7	0.3	2.6	1.1	-1.1
Intermittent access intake escalation 2	2.9	2.9	8.2	-2.0	0.2	2.9	1.0	-1.0
Intermitt. access day 1 inactive lever presses	0.6	0.7	1.2	0.3	0.9	0.3	1.1	-1.1
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.7	-0.5	0.2	0.8	0.4	-0.4
Intermitt. access escalation Index	0.8	0.7	1.2	-0.1	-0.9	-0.5	-1.1	1.1
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.2	0.0	-0.3	-0.0	0.0
Intermittent access day 15 total infusions	0.8	0.9	2.4	-1.0	0.2	1.5	0.7	-0.7
Intermittent access terminal intake (last 3 days)	0.4	0.4	1.2	-0.8	-0.1	1.1	0.3	-0.3
Intermittent access total infusions	0.1	0.1	0.2	-0.2	0.2	0.5	0.4	-0.4
Intermittent access day 1 locomotion	0.2	0.2	0.5	-0.5	0.0	0.7	0.3	-0.3
Intermittent access day 15 total locomotion	1.5	1.6	4.4	-1.8	-0.6	2.1	0.1	-0.1
Intermittent access total locomotion	0.4	0.5	1.1	-1.0	-0.5	1.0	-0.1	0.1
Intermittent access standard deviation	1.0	1.1	3.0	-1.2	0.2	1.7	0.7	-0.7
Left kidney weight	0.2	0.6	0.9	-0.5	-0.9	0.1	-0.9	0.9
Right kidney weight	0.7	1.9	4.0	-2.0	-1.0	2.0	-0.5	0.5
Cocaine induced anxiety	1.7	2.0	2.9	-1.3	-1.7	0.6	-1.6	1.6
Post-drug Anxiety	1.6	1.8	2.6	-1.3	-1.6	0.6	-1.5	1.5
Baseline Anxiety	0.6	0.6	1.1	0.0	0.8	0.5	1.0	-1.0
Tail length	1.2	3.6	11.0	-2.5	-0.5	3.3	0.5	-0.5
Length with tail	1.0	3.5	7.1	-2.6	-1.5	2.7	-0.8	0.8
Length without tail	0.7	1.6	2.4	-0.9	-1.6	0.2	-1.5	1.5
Times rat made contact with spout	0.9	1.0	1.6	0.9	1.3	-0.4	1.1	-1.1
Lifetime Intake	0.0	0.0	0.1	-0.1	0.1	0.3	0.2	-0.2
Liver weight, left	1.2	1.9	4.0	2.0	1.1	-1.9	0.6	-0.6
Liver weight, right	0.5	0.9	2.4	1.4	0.2	-1.5	-0.3	0.3
Locomotor activity	2.8	4.5	7.3	-2.7	-2.3	2.1	-1.7	1.7
Locomotor testing distance	1.3	2.2	4.1	-2.0	-1.5	1.6	-1.1	1.1
Locomotor testing rearing	0.3	0.5	0.8	0.3	0.8	0.1	0.9	-0.9
Locomotion in novel chamber	0.1	0.1	0.2	-0.3	0.3	0.4	0.3	-0.3
Locomotion in novel chamber post-restriction	0.4	0.5	1.5	-0.7	0.2	1.2	0.5	-0.5
Fecal boli incidents, locomotor time 1	1.0	1.1	2.5	1.6	0.9	-1.4	0.5	-0.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.4	0.4
Time >=10cm from walls, locomotor time 1	1.0	1.0	1.4	0.4	-0.8	-1.1	-1.2	1.2
Bouts of movement, locomotor time 1	0.1	0.1	0.4	-0.2	0.2	0.7	0.3	-0.3
Total resting periods, locomotor time 1	0.1	0.1	0.5	-0.4	-0.0	0.7	0.2	-0.2
Rest time, locomotor task time 1	0.4	0.4	0.8	-0.7	-0.7	0.9	-0.4	0.4
Distance moved, locomotor task time 1	0.7	0.8	1.4	0.3	-0.7	-1.2	-1.0	1.0
Vertical activity count, locomotor time 1	0.9	0.9	1.4	0.9	1.2	-0.8	1.0	-1.0
Time >=10cm from walls, locomotor time 2	1.3	1.4	2.8	1.7	1.1	-1.4	0.7	-0.7
Bouts of movement, locomotor time 2	1.6	1.7	2.4	-1.3	-1.5	0.7	-1.4	1.4
Total resting periods, locomotor time 2	1.6	1.7	2.5	-1.3	-1.6	0.6	-1.5	1.5
Rest time, locomotor task time 2	0.8	0.9	1.2	-1.1	-1.1	0.8	-0.9	0.9
Distance moved, locomotor task time 2	0.6	0.7	1.2	1.1	0.8	-0.9	0.6	-0.6
Vertical activity count, locomotor time 2	1.7	1.8	2.4	1.5	1.5	-0.8	1.4	-1.4
Light reinforcement 1	3.7	6.8	13.9	-3.7	-2.3	3.4	-1.4	1.4
Light reinforcement 2	1.4	1.9	4.0	-2.0	-1.3	1.6	-0.8	0.8
Bone: marrow area	0.1	0.1	0.2	0.5	-0.1	-0.5	-0.3	0.3
Bone: maximum diameter	1.0	1.9	2.5	-1.5	-1.6	1.1	-1.3	1.3
Bone: maximum force	0.5	0.9	2.2	1.4	0.3	-1.5	-0.1	0.1
Bone: maximum moment	0.4	0.7	1.8	1.2	0.2	-1.4	-0.2	0.2
Mean time between licks in bursts	1.6	2.3	6.3	-2.2	-0.5	2.5	0.2	-0.2
Mean num. licks in bursts	0.0	0.0	0.1	0.0	-0.2	-0.2	-0.3	0.3
Cd content in liver	0.1	0.1	0.5	0.3	-0.1	-0.7	-0.2	0.2
Co content in liver	0.2	0.3	0.8	-0.7	-0.2	0.9	0.2	-0.2
Cu content in liver	0.7	0.9	1.5	-0.2	-1.1	-0.4	-1.2	1.2
Fe content in liver	0.1	0.2	0.3	0.1	0.3	0.5	0.5	-0.5
K content in liver	1.5	1.5	2.5	-0.6	-1.6	0.1	-1.5	1.5
Mg content in liver	1.4	1.5	2.3	-0.6	-1.5	-0.1	-1.5	1.5
Mn content in liver	4.1	4.6	7.3	-1.9	-2.7	1.0	-2.4	2.4
Na content in liver	1.1	1.2	1.8	0.3	-1.2	-0.8	-1.3	1.3
Rb content in liver	0.9	1.1	1.9	-0.0	-1.2	-0.7	-1.4	1.4
Se content in liver	0.3	0.3	0.6	-0.6	-0.6	0.8	-0.4	0.4
Sr content in liver	0.9	0.8	1.4	0.4	1.1	0.1	1.2	-1.2
Zn content in liver	1.9	2.1	3.1	-0.5	1.3	1.4	1.8	-1.8
Bone: minimum diameter	0.1	0.2	0.3	-0.1	-0.6	0.1	-0.6	0.6
Time in familiar zone, hab. session 1	1.1	1.0	2.4	-1.1	0.4	1.6	0.8	-0.8
Time in novel zone, hab. session 1	0.9	0.9	1.4	0.6	-0.7	-1.2	-1.1	1.1
Total zone transitions, hab. session 1	2.9	4.1	6.0	-1.9	-2.4	1.1	-2.2	2.2
Total locomotion distance, hab. session 1	4.5	6.4	9.8	-2.2	-3.1	1.3	-2.8	2.8
Locomotion velocity, hab. session 1	4.6	6.6	9.7	-2.4	-3.1	1.6	-2.7	2.7
Time in familiar zone, hab. session 2	2.6	2.7	7.3	-1.9	0.3	2.7	1.1	-1.1
Time in novel zone, hab. session 2	2.0	2.0	5.6	1.7	-0.1	-2.4	-0.9	0.9
Total zone transitions, hab. session 2	4.0	5.2	8.9	-1.0	-2.7	-0.4	-3.0	3.0
Total locomotion distance, hab. session 2	3.5	4.6	6.2	-2.0	-2.5	1.1	-2.4	2.4
Locomotion velocity, hab. session 2	4.7	6.3	8.8	-2.2	-3.0	1.1	-2.9	2.9
Novel to familiar place preference ratio	2.3	2.3	5.4	1.5	-0.6	-2.3	-1.3	1.3
Novelty place preference	1.6	1.6	3.3	1.1	-0.7	-1.8	-1.3	1.3
Time in novel zone, NPP test	1.5	1.6	3.6	1.3	-0.5	-1.9	-1.1	1.1
Total zone transitions, NPP test	2.2	3.1	5.0	-1.0	-2.1	-0.1	-2.2	2.2
Total locomotion distance, NPP test	2.1	2.9	4.8	-0.8	-2.1	-0.0	-2.2	2.2
Locomotion velocity, NPP test	2.3	3.2	5.0	-1.1	-2.2	0.2	-2.2	2.2
Intraocular pressure	1.8	2.5	4.0	0.7	2.0	0.0	2.0	-2.0
Delta distance traveled before/after self-admin	0.9	0.9	2.2	-1.4	-0.7	1.5	-0.2	0.2
Delta ambulatory time before/after self-admin	1.1	1.2	2.5	-1.5	-0.9	1.6	-0.4	0.4
Parametrial fat weight	0.2	0.3	0.9	-0.4	0.3	0.9	0.5	-0.5
Pavlov. Cond. lever latency	1.2	1.5	2.5	0.5	1.6	-0.2	1.5	-1.5
Pavlov. Cond. magazine entry latency	1.6	2.1	5.9	-1.9	-0.8	2.4	-0.1	0.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	-0.4	-0.6	0.6	-0.4	0.4
Pavlov. Cond. index score	1.0	1.3	1.9	-1.1	-1.4	1.1	-1.0	1.0
Pavlov. Cond. latency score	1.6	2.0	3.2	-1.2	-1.8	1.1	-1.4	1.4
Pavlov. Cond. lever contacts	1.8	2.1	3.6	-0.8	-1.9	0.4	-1.8	1.8
Pavlov. Cond. magazine entry number	0.6	0.7	1.8	1.0	0.7	-1.3	0.3	-0.3
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.0	0.0	0.9	0.3	1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.4	1.9	-1.3	-1.4	1.4	-0.9	0.9
Pavlov. Cond. response bias	0.9	1.1	2.5	-1.3	-0.9	1.6	-0.4	0.4
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.6	-0.1	-0.8	-0.3	0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	-0.5	-0.2	0.8	0.1	-0.1
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	-0.6	0.2	0.7	0.5	-0.5
Pavlov. Cond. index score	0.3	0.3	0.9	-0.6	0.1	0.9	0.4	-0.4
Pavlov. Cond. latency score	0.2	0.2	0.7	-0.7	-0.1	0.8	0.2	-0.2
Pavlov. Cond. lever contacts	0.3	0.5	0.8	-0.4	0.5	0.9	0.8	-0.8
Pavlov. Cond. magazine entry number	0.3	0.3	1.0	0.7	0.2	-1.0	-0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.3	0.9	1.1	-0.5	1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.9	-0.7	-0.1	0.9	0.2	-0.2
Pavlov. Cond. response bias	0.7	0.9	2.2	-0.9	0.4	1.5	0.8	-0.8
Time in closed arm before self-admin	1.4	1.6	2.6	0.1	-1.4	-0.9	-1.6	1.6
Time in closed arm after self-admin	0.0	0.0	0.0	-0.0	0.2	0.2	0.2	-0.2
Time in open arm before self-admin	0.3	0.3	0.8	-0.6	0.1	0.9	0.4	-0.4
Time in open arm after self-admin	0.4	0.5	1.0	1.0	0.6	-1.0	0.3	-0.3
Bone: periosteal estimation	0.3	0.6	0.8	0.3	-0.7	-0.8	-0.9	0.9
Bone: periosteal perimeter	0.4	0.7	1.2	-0.5	-1.1	0.2	-1.0	1.0
Bone: post-yield work	0.4	0.5	1.1	1.1	0.7	-0.6	0.6	-0.6
Progressive ratio test 1 active lever presses	0.4	0.4	0.7	0.5	0.8	-0.1	0.8	-0.8
Progressive ratio test 1 breakpoint	0.4	0.4	0.6	0.6	0.8	-0.2	0.7	-0.7
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.2	0.0	0.2	0.1	-0.1
Progressive ratio test 2 active lever presses	0.4	0.5	0.8	0.1	0.7	0.4	0.9	-0.9
Progressive ratio test 2 breakpoint	0.1	0.2	0.2	-0.2	0.3	0.5	0.5	-0.5
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.2	0.2
Incentive Sensitization - Responses	0.4	0.4	0.7	0.2	0.7	0.3	0.8	-0.8
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	0.1	0.6	0.4	0.7	-0.7
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.2	0.2
Progressive ratio	0.1	0.1	0.2	0.4	0.3	-0.2	0.2	-0.2
Food seeking constrained by brief footshock	0.6	0.7	1.0	-0.9	-1.0	0.8	-0.8	0.8
Seeking ratio, punishment vs. effort	0.4	0.5	0.7	-0.8	-0.8	0.5	-0.7	0.7
Retroperitoneal fat weight	0.1	0.5	1.0	1.0	0.7	-0.7	0.5	-0.5
Reaction time number correct	2.4	3.4	5.1	1.6	2.3	-0.7	2.1	-2.1
Reaction time mean minus median	0.3	0.3	0.8	-0.5	0.2	0.9	0.5	-0.5
Reaction time mean minus median AUC	0.3	0.4	0.6	-0.3	-0.8	-0.0	-0.8	0.8
Reaction time num false alarms	1.4	1.9	2.8	1.1	1.6	-0.3	1.7	-1.7
Reaction time num false alarms AUC	1.8	2.5	3.6	1.3	1.8	-0.3	1.9	-1.9
Reaction time trials correct on left	2.4	3.4	5.1	1.6	2.3	-0.7	2.1	-2.1
Reaction time trials on left	2.2	3.1	4.7	1.6	2.2	-0.7	2.0	-2.0
Reaction time mean	0.1	0.1	0.2	-0.1	-0.3	-0.3	-0.4	0.4
Reaction time mean AUC	0.1	0.1	0.2	-0.0	-0.3	-0.4	-0.5	0.5
Median of all reaction times	0.2	0.3	0.6	0.3	-0.3	-0.8	-0.6	0.6
Reaction time omissions	0.3	0.4	0.6	-0.8	-0.6	0.4	-0.6	0.6
Reaction time false alarm rate	0.1	0.1	0.2	0.4	0.3	-0.2	0.4	-0.4
Reaction time premature initiation rate	0.4	0.6	1.2	-0.8	0.4	1.1	0.7	-0.7
Reaction time premature initiations	1.4	2.0	3.4	0.0	1.6	0.9	1.8	-1.8
Std. dev. reaction times	0.0	0.1	0.2	-0.3	-0.0	0.4	0.1	-0.1
Reaction time trials completed	2.2	3.1	4.7	1.6	2.2	-0.7	2.0	-2.0
Reaction time trials AUC	2.7	3.9	5.9	1.7	2.4	-0.6	2.3	-2.3
Run reversals in cocaine runway, females	0.3	0.3	0.5	-0.7	-0.5	0.7	-0.3	0.3
Run reversals in cocaine runway, males	1.1	1.1	2.2	-1.5	-0.9	1.3	-0.6	0.6
Latency to leave start box in cocaine runway	1.8	2.0	2.7	-1.4	-1.6	0.4	-1.6	1.6
Latency to leave start box in cocaine runway, F	2.5	2.7	4.6	-0.7	-1.9	-0.7	-2.1	2.1
Latency to leave start box in cocaine runway, M	1.3	1.3	3.2	-1.0	0.5	1.8	1.0	-1.0
Std. dev. time between licks in bursts	0.5	0.6	1.0	-1.0	-0.7	0.9	-0.5	0.5
Total sessions with >9 infusions	0.1	0.1	0.2	0.0	-0.3	-0.2	-0.4	0.4
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.3	-0.2	0.3	-0.1	0.1
Short access day 10 total inactive lever presses	0.1	0.1	0.1	0.2	0.3	-0.0	0.3	-0.3
Short access day 1 total infusions	0.6	0.6	1.0	-0.8	-1.0	0.4	-0.8	0.8
Short access day 10 total infusions	0.3	0.3	0.6	0.2	0.6	0.3	0.7	-0.7
Short access total infusions	0.0	0.0	0.0	-0.0	-0.1	-0.0	-0.1	0.1
Short access day 1 locomotion	0.7	0.8	1.4	-1.2	-0.9	1.0	-0.6	0.6
Short access day 10 total locomotion	1.4	1.5	4.5	-1.7	-0.3	2.1	0.4	-0.4
Short access total locomotion	0.4	0.4	0.8	-0.9	-0.5	0.9	-0.2	0.2
One hour access (0.3 mA shock)	0.1	0.2	0.2	0.5	0.4	-0.4	0.3	-0.3
Compulsive drug intake	0.7	0.7	1.7	0.8	-0.3	-1.3	-0.7	0.7
One hour access (shock baseline)	0.6	0.7	1.2	0.2	0.9	0.4	1.1	-1.1
Social response proportion	1.4	1.5	2.0	-1.4	-1.4	0.8	-1.2	1.2
Social responses	4.1	5.3	10.5	-3.2	-2.1	2.9	-1.2	1.2
Social time	0.3	0.3	0.9	0.6	-0.2	-1.0	-0.5	0.5
Soleus weight	4.5	13.1	28.4	5.2	2.6	-5.3	1.2	-1.2
Bone: stiffness	1.1	1.8	4.3	2.1	0.5	-2.1	-0.0	0.0
Tibialis anterior weight	0.6	1.9	4.6	2.1	1.0	-1.9	0.5	-0.5
Time to tail flick, vehicle, before self-admin	1.3	1.3	1.8	-1.1	-1.4	0.5	-1.3	1.3
Time to tail flick, vehicle, after self-admin	1.0	1.0	1.8	0.2	1.1	0.5	1.4	-1.4
Time to tail flick, test, before self-admin	1.0	1.0	1.4	-0.8	-1.2	0.3	-1.2	1.2
Time to tail flick, test, after self-admin	0.4	0.4	0.6	-0.8	-0.7	0.6	-0.6	0.6
Delta time to tail flick, vehicle, before/after SA	2.5	2.4	3.5	1.3	1.9	-0.3	1.9	-1.9
Delta time to tail flick, test, before/after SA	0.5	0.5	0.8	-0.0	0.7	0.6	0.9	-0.9
Tibia length	0.3	1.0	2.6	-1.4	-0.4	1.6	0.1	-0.1
Ambulatory time before self-admin	0.3	0.3	0.7	0.5	-0.1	-0.8	-0.4	0.4
Ambulatory time after self-admin	0.3	0.3	0.5	-0.7	-0.6	0.5	-0.5	0.5
Bone: tissue strength	0.7	0.7	2.1	1.0	0.1	-1.5	-0.4	0.4
Total heroin consumption	1.0	1.1	2.4	-1.6	-0.7	1.6	-0.3	0.3
Bone: trabecular number	1.6	2.4	3.6	-1.6	-1.9	0.8	-1.7	1.7
Bone: trabecular spacing	4.0	5.2	7.9	1.8	2.8	-0.5	2.7	-2.7
Bone: trabecular thickness	5.7	6.8	11.0	-1.4	-3.1	-0.6	-3.3	3.3
Bone: trabecular tissue density	0.9	1.2	2.5	1.6	1.0	-1.4	0.6	-0.6
Water consumed over 24 hours	0.3	0.4	0.8	0.5	-0.3	-0.9	-0.7	0.7
Number of responses in last shaping day	0.0	0.0	0.1	-0.2	0.0	0.3	0.2	-0.2