Psmc5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Psmc5	0.04	0.02	7.0e-04	0.02	0.02	0.02	0.01	6.4e-03	4.9e-03	5.7e-03	2.7e-02
2	Brain	mRNA stability	Psmc5	0.1	0.05	2.5e-04	0.03	0.03	0.04	0.04	1.3e-03	7.4e-04	1.5e-04	2.5e-04
3	Brain	gene expression	Psmc5	0.09	0.04	8.6e-04	0.02	0.02	0.02	0.02	3.8e-03	5.0e-03	6.2e-03	3.5e-03
4	PL	gene expression	Psmc5	0.06	0.03	1.9e-03	0.01	0.02	0.02	0.02	6.8e-02	2.5e-03	1.9e-03	2.5e-03
5	Adipose	gene expression	Psmc5	0.29	0.08	0.0e+00	0.22	0.24	0.25	0.25	6.8e-24	1.1e-26	1.2e-27	3.6e-27

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	4.7	7.8	9.8	-2.7	-2.8	-3.1	2.5	2.8
Area under the delay curve	0.1	0.1	0.3	0.2	-0.2	-0.3	-0.5	0.5
BMI with tail	2.4	7.9	21.5	3.0	1.5	2.1	-4.6	-1.5
BMI without tail	2.4	4.9	17.0	1.5	0.4	1.7	-4.1	-1.5
Body weight	0.6	2.6	7.9	-0.0	-0.5	1.0	-2.8	-2.0
Weight adjusted by age	1.0	1.1	1.9	1.4	1.3	0.9	-0.9	-0.7
Bone surface	7.8	13.7	19.6	-4.4	-4.3	-3.9	3.4	1.9
Bone volume	6.3	10.7	14.6	-3.8	-3.8	-3.5	2.9	2.0
Breakpoint value in progressive ratio session	0.7	0.7	1.4	-1.2	-0.5	0.4	0.7	-1.2
Number of licking bursts	0.1	0.1	0.1	-0.3	0.1	-0.3	0.4	-0.1
Context. condit. distance diff. score	1.7	2.1	2.6	0.9	1.5	1.5	-1.6	-1.5
Locomotion velocity, session 1	1.8	2.0	2.8	-1.6	-1.7	-1.4	0.9	1.2
Locomotion distance, session 1	0.5	0.6	1.3	-0.4	-0.6	-0.8	-0.7	1.2
Locomotion velocity, session 2	1.8	2.1	4.8	-2.2	-1.3	-1.3	1.6	0.3
Locomotion distance, session 2	0.2	0.3	0.9	-1.0	0.3	-0.3	-0.5	0.1
Locomotion velocity, session 3	0.3	0.3	0.7	-0.2	0.3	-0.8	-0.2	0.8
Locomotion distance, session 3	0.5	0.6	1.2	-0.9	-0.2	-1.1	0.7	0.6
Stereotopy head waving bouts, day 3	0.5	0.6	2.2	0.1	-0.2	-0.8	0.3	1.5
Stereotopy head waving duration, day 3	0.2	0.3	0.5	0.5	0.7	0.3	-0.6	0.4
Locomotion velocity, session 7	0.1	0.1	0.4	0.1	0.2	-0.3	0.3	0.6
Locomotion distance, session 7	0.3	0.3	0.8	0.4	0.6	0.4	-0.9	-0.4
Stereotopy head waving bouts, day 7	0.5	0.5	1.2	-0.6	-0.0	-0.9	0.6	1.1
Stereotopy head waving duration, day 7	0.5	0.6	1.2	-0.5	0.8	-0.4	1.1	0.9
Locomotion velocity, session 8	0.7	0.9	2.9	-0.3	0.6	1.0	-0.0	-1.7
Locomotion distance, session 8	0.9	1.3	1.8	-0.0	1.4	1.1	-1.3	-1.3
Degree of sensitization distance	1.4	1.4	2.2	0.9	0.6	1.5	-1.5	-1.2
Degree of sensitization stereotypy	0.2	0.3	0.4	-0.6	0.4	-0.6	0.3	0.6
Conditioned locomotion	0.3	0.3	0.8	0.1	-0.1	0.9	-0.4	-0.9
Cocaine response after cond. corrected	0.4	0.5	1.2	0.4	-0.2	-1.1	0.6	0.8
Cocaine response after cond. not corrected	2.1	2.3	4.8	-0.7	-0.8	-2.2	1.9	1.5
Cocaine response before conditioning	1.5	1.8	2.9	-1.7	-0.7	-1.5	1.5	1.1
Saline control response	1.1	1.4	3.7	-0.1	-0.2	1.5	-1.1	-1.9
Bone: connectivity density	5.0	7.9	9.9	-3.1	-2.9	-3.0	2.5	2.3
Bone: cortical apparent density	2.4	3.1	4.8	2.2	2.2	0.7	-1.8	1.6
Bone: cortical area	2.1	3.1	5.9	-1.6	-2.1	-2.4	0.2	1.6
Bone: cortical porosity	11.8	12.9	20.3	-4.0	-4.5	-3.7	3.8	0.6
Bone: cortical porosity	6.8	7.4	11.9	-3.0	-3.5	-3.1	2.5	0.7
Bone: cortical thickness	2.7	4.5	14.3	1.3	0.4	-2.1	-1.3	3.8
Bone: cortical thickness	2.2	2.5	8.4	0.3	-0.2	-2.0	-0.3	2.9
Bone: cortical tissue density	2.3	3.0	4.8	2.1	2.2	0.8	-1.7	1.5
Condit. Reinf. active minus inactive responses	1.3	1.4	3.4	-1.8	-1.7	-0.6	0.5	-0.6
Condit. Reinf. active-inactive response ratio	0.8	0.8	2.2	-1.5	-1.1	-0.5	0.5	-0.5
Condit. Reinf. active responses	1.1	1.3	3.6	-1.9	-1.5	-0.4	0.5	-0.8
Condit. Reinf. inactive responses	0.1	0.1	0.5	-0.7	-0.5	-0.0	0.0	-0.0
Incentive salience index mean	2.3	2.8	6.4	-2.5	-2.0	-1.3	1.5	0.1
Condit. Reinf. lever presses	1.1	1.5	2.9	-1.7	-0.9	-1.0	1.6	0.4
Condit. Reinf. active minus inactive responses	4.8	5.9	15.0	-3.9	-2.7	-2.3	1.3	0.5
Condit. Reinf. active-inactive response ratio	5.6	5.9	10.6	-3.3	-2.6	-2.4	2.2	0.9
Condit. Reinf. active responses	2.9	4.0	11.0	-3.3	-2.6	-1.4	0.6	-0.2
Condit. Reinf. inactive responses	0.7	0.8	1.9	-0.7	-0.6	0.7	-1.4	-1.0
Condit. Reinf. lever presses	1.1	1.5	4.0	-2.0	-1.6	-1.1	0.2	-0.0
Condit. Reinf. lever reinforcers received	2.8	3.9	9.6	-3.1	-2.6	-1.5	0.7	0.0
Conditioned reinforcement - actives	0.6	0.6	1.2	-0.0	-0.1	1.1	-0.6	-1.1
Conditioned reinforcement - inactives	0.2	0.3	0.7	-0.6	-0.8	-0.3	-0.4	-0.3
Conditioned locomotion	0.7	0.8	2.8	-1.0	-1.7	-0.1	-0.1	-0.5
Patch foraging indifference point 0 sec	0.7	1.2	2.4	-1.5	-1.2	-0.0	-1.2	-0.8
Patch foraging indifference point AUC	0.7	0.8	1.8	-0.1	0.3	1.0	-1.0	-1.3
Delay disc. indifference point, 0s delay	0.2	0.2	0.5	0.7	0.7	0.2	-0.2	0.3
Delay disc. indifference point, 16s delay	0.3	0.3	0.4	0.4	-0.5	-0.4	-0.7	0.5
Delay disc. indifference point, 2s delay	0.4	0.5	0.9	-0.9	-0.4	-0.7	0.3	1.0
Delay disc. indifference point, 24s delay	0.7	0.6	2.7	0.2	-0.3	0.5	-1.7	-0.3
Delay disc. indifference point, 4s delay	0.7	0.8	1.8	0.0	-0.4	-1.3	0.7	1.2
Delay disc. indifference point, 8s delay	0.5	0.5	1.7	0.3	-0.1	-0.6	-0.4	1.3
Indifference point function ln k	0.8	1.1	3.0	-0.4	-0.5	-1.4	0.5	1.7
Indifference point function log k	0.8	1.1	3.0	-0.4	-0.5	-1.4	0.5	1.7
Patch foraging total patch changes 0 sec	0.8	1.2	2.6	-1.6	-1.4	-0.2	-1.1	-0.7
Patch foraging total patch changes 12 sec	1.5	1.9	4.8	-1.5	-0.4	1.3	-0.9	-2.2
Patch foraging total patch changes 18 sec	0.7	0.9	2.0	-1.0	-0.9	0.1	-0.9	-1.4
Patch foraging total patch changes 24 sec	0.9	1.1	2.8	-1.7	-1.4	-0.4	-0.8	-0.2
Patch foraging total patch changes 6 sec	0.5	0.8	1.8	-1.3	-1.1	-0.3	-0.6	-0.6
Patch foraging time to switch 0 sec	0.3	0.5	2.0	-0.2	-0.5	-0.3	1.4	0.1
Patch foraging water rate 0 sec	0.3	0.6	1.4	-0.4	-1.0	-0.4	-1.2	0.2
Patch foraging water rate 12 sec	1.0	1.6	3.8	0.6	-0.1	-1.7	-0.7	2.0
Patch foraging water rate 18 sec	1.4	1.9	4.2	-1.1	-0.6	-1.9	0.2	2.1
Patch foraging water rate 24 sec	0.2	0.2	0.6	-0.3	0.1	-0.8	-0.1	0.6
Patch foraging water rate 6 sec	1.3	1.9	5.2	-0.3	-1.1	-1.8	0.2	2.3
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	1.7	0.8	0.5	1.1	-1.3	-1.0
Distance traveled before self-admin	0.3	0.3	0.9	-0.0	-0.1	-0.9	0.8	0.1
Distance traveled after self-admin	0.2	0.3	1.0	-0.3	0.1	-0.3	0.4	-1.0
Extensor digitorum longus weight	4.9	19.2	35.5	6.0	3.9	4.8	-3.7	-2.9
Bone: elastic displacement	0.8	0.9	2.8	0.2	0.2	-1.2	0.1	1.7
Bone: elastic work	1.3	1.7	3.4	-0.6	-1.2	-1.7	0.6	1.9
Bone: endosteal estimation	6.4	14.0	28.2	-5.3	-5.0	-2.0	3.0	-2.0
Bone: endosteal perimeter	5.7	11.7	23.8	-4.9	-4.6	-1.7	2.3	-2.4
Epididymis fat weight	0.3	0.7	1.1	0.9	-0.9	0.6	-1.0	-0.5
Delta time in closed arm before/after self-admin	1.0	1.0	1.5	-1.1	-0.6	-1.2	1.2	0.6
Delta time in open arm before/after self-admin	2.6	2.5	4.0	1.7	1.5	2.0	-1.5	-0.8
Diff in mean of infusions in LGA sessions	0.7	0.8	1.4	1.2	1.0	0.8	-0.9	-0.3
Delay discount exponential model param	0.1	0.1	0.1	-0.0	0.3	0.3	0.3	-0.4
Extinction: sum of active levers before priming	1.4	1.4	2.6	0.4	0.9	1.5	-1.1	-1.6
Active lever presses in extinction session 6	0.9	0.9	2.4	-1.0	-1.5	-0.6	0.6	-0.6
Bone: final force	1.9	3.1	6.0	-1.7	-1.7	-2.5	0.6	1.8
Bone: final moment	2.3	3.7	6.9	-1.9	-1.8	-2.6	0.8	1.9
Food consumed during 24 hour testing period	0.9	1.1	2.7	-0.0	-0.2	1.1	-1.1	-1.6
Glucose	0.3	0.5	1.3	1.1	1.0	0.3	-0.2	-0.1
Heart weight	0.6	0.9	2.3	1.0	0.8	0.4	-1.5	-0.5
Delay discount hyperbolic model param	0.1	0.1	0.3	-0.0	0.3	0.4	0.3	-0.6
Intermittent access intake day 1-15 change	0.5	0.5	1.3	-0.1	-0.4	0.0	1.0	-1.1
Intermittent access intake escalation	0.3	0.3	0.7	0.1	-0.1	0.1	0.8	-0.8
Intermittent access intake escalation 2	0.5	0.5	1.4	-0.4	-0.8	-0.1	1.2	-0.8
Intermitt. access day 1 inactive lever presses	3.2	3.5	7.4	-2.7	-2.2	-2.1	1.0	0.3
Intermitt. access day 15 inactive lever presses	2.7	3.0	6.7	-1.2	-2.6	-1.9	1.3	1.1
Intermitt. access escalation Index	0.9	0.8	2.9	0.8	1.7	0.5	0.0	-0.2
Intermittent access day 1 total infusions	0.3	0.3	1.5	-0.1	-0.1	0.1	-1.2	-0.2
Intermittent access day 15 total infusions	0.6	0.7	1.5	0.4	0.2	1.0	-0.8	-1.2
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.3	-0.5	-0.7	0.5	-0.2	-1.1
Intermittent access total infusions	0.5	0.6	1.0	-0.8	-0.6	0.5	-0.7	-1.0
Intermittent access day 1 locomotion	0.8	0.9	2.4	-1.1	-1.5	-0.0	-0.7	-0.6
Intermittent access day 15 total locomotion	1.2	1.3	2.1	-1.5	-1.4	0.5	-0.4	-1.5
Intermittent access total locomotion	1.7	1.9	4.8	-1.9	-2.2	-0.1	-0.6	-1.0
Intermittent access standard deviation	0.4	0.4	1.4	-0.6	-1.2	-0.6	0.1	-0.1
Left kidney weight	0.5	1.5	4.5	0.8	0.9	-0.6	-2.1	1.2
Right kidney weight	0.3	0.9	2.2	-0.2	0.3	-1.1	-1.0	1.5
Cocaine induced anxiety	1.6	1.8	3.7	-0.0	-1.4	-1.7	0.6	1.9
Post-drug Anxiety	1.7	1.9	3.8	0.4	-1.4	-1.8	0.7	2.0
Baseline Anxiety	0.3	0.3	0.7	0.9	0.6	-0.0	-0.4	0.5
Tail length	0.4	1.2	3.0	-1.7	-1.6	-0.3	0.2	-0.6
Length with tail	0.7	2.7	6.7	-2.6	-1.8	-1.0	1.4	-0.4
Length without tail	0.9	2.1	4.6	-1.7	-1.0	-1.3	2.1	0.5
Times rat made contact with spout	0.3	0.4	0.8	-0.9	-0.9	-0.2	0.4	-0.2
Lifetime Intake	0.5	0.6	1.1	-1.1	-0.8	0.1	-0.8	-0.7
Liver weight, left	0.5	0.8	3.0	-1.7	-0.2	-0.4	0.9	0.0
Liver weight, right	0.9	1.4	4.9	0.2	0.3	-1.3	-0.6	2.2
Locomotor activity	0.6	0.9	2.0	-1.2	0.3	0.5	-1.4	-0.9
Locomotor testing distance	0.8	1.3	2.1	-1.3	-0.5	0.7	-1.4	-1.4
Locomotor testing rearing	1.0	1.6	4.7	-1.3	-0.7	1.0	-0.4	-2.2
Locomotion in novel chamber	0.3	0.4	0.7	-0.7	-0.6	-0.9	0.6	0.1
Locomotion in novel chamber post-restriction	0.5	0.6	1.3	-1.1	-1.0	-0.4	0.8	-0.2
Fecal boli incidents, locomotor time 1	0.3	0.3	0.6	0.7	0.3	0.6	0.0	-0.7
Change in fecal boli incidents, locomotor task	0.6	0.6	1.6	1.3	0.2	0.2	-1.1	0.3
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.6	0.5	1.3	-0.1	0.1	0.0
Bouts of movement, locomotor time 1	0.3	0.3	1.0	1.0	-0.0	0.0	-0.4	0.6
Total resting periods, locomotor time 1	0.4	0.4	1.0	1.0	-0.2	-0.2	-0.2	0.9
Rest time, locomotor task time 1	0.6	0.7	1.3	-0.1	-0.5	-0.7	1.1	1.1
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.4	-0.3	-0.0	-0.4	-0.3
Vertical activity count, locomotor time 1	0.4	0.4	0.7	-0.7	-0.7	-0.8	0.2	0.4
Time >=10cm from walls, locomotor time 2	1.2	1.3	3.1	-0.8	-0.9	-1.3	1.8	0.6
Bouts of movement, locomotor time 2	0.4	0.4	1.6	1.3	0.1	0.3	-0.6	0.1
Total resting periods, locomotor time 2	0.4	0.5	1.8	1.3	0.2	0.2	-0.6	0.2
Rest time, locomotor task time 2	1.2	1.4	4.4	2.1	1.4	0.5	-0.2	0.6
Distance moved, locomotor task time 2	1.0	1.1	2.0	-1.4	-1.2	-1.0	1.0	0.3
Vertical activity count, locomotor time 2	2.1	2.3	4.7	-2.2	-2.1	-1.1	1.1	0.1
Light reinforcement 1	0.4	0.8	3.0	0.4	0.5	0.5	-1.7	0.3
Light reinforcement 2	0.4	0.5	1.5	-0.2	-0.6	-0.5	-0.4	1.2
Bone: marrow area	6.5	14.0	28.0	-5.3	-5.0	-2.0	3.1	-1.9
Bone: maximum diameter	3.3	6.1	10.8	-3.2	-3.3	-2.6	1.7	0.5
Bone: maximum force	1.3	2.2	4.0	-1.4	-1.9	-2.0	-0.3	1.3
Bone: maximum moment	1.6	2.7	4.8	-1.6	-2.1	-2.2	0.1	1.4
Mean time between licks in bursts	0.4	0.6	1.0	1.0	0.3	0.8	-1.0	-0.7
Mean num. licks in bursts	0.2	0.2	0.4	0.3	-0.5	0.5	-0.6	-0.1
Cd content in liver	2.1	2.3	4.0	1.9	2.0	1.6	-1.0	-0.7
Co content in liver	1.3	1.6	2.7	0.7	1.4	1.6	0.0	-1.6
Cu content in liver	0.3	0.3	0.7	-0.3	-0.8	-0.2	0.8	0.3
Fe content in liver	0.0	0.1	0.1	-0.3	0.3	0.1	-0.3	0.1
K content in liver	1.1	1.0	2.6	-1.6	-0.3	-0.3	1.6	-0.2
Mg content in liver	0.6	0.6	2.0	-0.6	0.6	0.6	1.4	-0.1
Mn content in liver	1.2	1.4	2.7	-1.6	-0.1	-1.1	1.1	1.4
Na content in liver	0.6	0.7	2.2	-1.5	0.3	-0.0	0.8	-0.6
Rb content in liver	0.6	0.8	2.9	0.5	1.7	0.5	0.4	0.6
Se content in liver	1.2	1.5	3.7	1.0	1.9	1.2	-1.0	-0.4
Sr content in liver	0.6	0.6	1.2	-0.6	-0.9	-1.1	0.2	0.7
Zn content in liver	0.2	0.2	0.5	-0.7	0.2	-0.3	0.2	0.6
Bone: minimum diameter	4.2	7.8	17.8	-3.8	-4.2	-1.9	1.5	-1.1
Time in familiar zone, hab. session 1	1.3	1.2	3.4	0.5	0.4	1.4	-0.3	-1.8
Time in novel zone, hab. session 1	1.1	1.1	3.4	0.1	-0.4	-1.4	0.0	1.8
Total zone transitions, hab. session 1	0.3	0.5	2.0	0.1	0.5	0.3	-1.4	-0.3
Total locomotion distance, hab. session 1	1.0	1.5	2.4	-1.3	-1.1	-1.6	-0.4	1.4
Locomotion velocity, hab. session 1	0.8	1.2	2.0	-1.4	-1.1	-1.3	-0.3	1.0
Time in familiar zone, hab. session 2	1.7	1.7	5.9	-0.5	0.4	1.4	-0.5	-2.4
Time in novel zone, hab. session 2	2.8	2.8	8.9	0.3	-0.8	-2.0	0.6	3.0
Total zone transitions, hab. session 2	0.6	0.8	1.1	0.1	1.0	0.9	-1.1	-0.9
Total locomotion distance, hab. session 2	0.2	0.3	1.3	-0.2	0.3	0.4	-1.1	0.0
Locomotion velocity, hab. session 2	0.3	0.3	1.4	-0.1	0.4	0.4	-1.2	0.1
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.2	-0.7	-0.5	0.2	0.3
Novelty place preference	0.2	0.2	0.3	-0.2	-0.5	-0.5	0.2	0.4
Time in novel zone, NPP test	0.3	0.3	0.5	-0.4	-0.6	-0.7	0.3	0.5
Total zone transitions, NPP test	0.4	0.6	2.4	-0.2	0.7	0.1	-1.6	0.3
Total locomotion distance, NPP test	0.6	0.8	1.2	-1.1	-0.7	-1.0	-0.4	1.1
Locomotion velocity, NPP test	0.3	0.5	1.9	-0.2	-0.1	-0.2	-1.4	0.6
Intraocular pressure	1.1	1.5	3.8	1.5	-0.3	0.9	-2.0	-0.7
Delta distance traveled before/after self-admin	0.1	0.1	0.5	-0.1	0.4	0.2	-0.7	-0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.4	-0.0	0.0	-0.3	-0.1
Parametrial fat weight	1.4	2.8	3.2	-1.2	-1.8	-1.8	1.8	1.7
Pavlov. Cond. lever latency	2.6	3.3	6.9	2.6	1.7	2.0	-1.5	-0.8
Pavlov. Cond. magazine entry latency	2.8	3.6	8.0	-2.8	-2.0	-1.7	1.7	0.3
Pavlov. Cond. change in total contacts	2.7	2.9	6.2	-2.5	-1.8	-1.5	1.7	0.4
Pavlov. Cond. index score	2.6	3.3	7.7	-2.8	-1.8	-1.8	1.5	0.3
Pavlov. Cond. latency score	1.9	2.4	6.5	-2.6	-1.4	-1.5	1.2	0.1
Pavlov. Cond. lever contacts	2.0	2.3	4.7	-2.2	-1.5	-1.4	1.6	0.2
Pavlov. Cond. magazine entry number	2.7	3.4	7.2	2.7	1.8	1.7	-1.7	-0.6
Pavlov. Cond. intertrial magazine entries	1.9	2.3	5.1	0.7	0.5	1.8	-2.3	-1.6
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.2	6.8	-2.6	-1.8	-1.9	1.6	0.5
Pavlov. Cond. response bias	5.1	6.2	10.7	-3.3	-2.6	-2.6	2.4	1.2
Pavlov. Cond. lever latency	0.2	0.3	1.3	1.1	0.4	0.4	-0.0	0.2
Pavlov. Cond. magazine entry latency	0.6	0.7	2.4	0.7	1.6	0.6	-0.1	-0.2
Pavlov. Cond. change in total contacts	0.5	0.7	1.6	-1.0	0.2	0.8	-0.1	-1.3
Pavlov. Cond. index score	0.1	0.1	0.5	-0.7	0.1	-0.1	0.1	-0.4
Pavlov. Cond. latency score	0.1	0.2	0.6	-0.8	-0.0	-0.3	0.3	-0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.8	-0.9	-0.4	-0.3	-0.3	-0.1
Pavlov. Cond. magazine entry number	0.5	0.6	2.3	-0.6	-1.5	-0.3	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	2.2	2.9	9.4	-1.8	-3.1	-0.5	0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	-0.6	0.2	-0.1	0.1	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.6	0.0	-0.1	-0.3	-0.1
Time in closed arm before self-admin	0.2	0.3	0.8	-0.2	0.1	-0.6	-0.2	0.9
Time in closed arm after self-admin	0.4	0.4	0.9	-0.9	0.3	-0.4	1.0	0.2
Time in open arm before self-admin	0.2	0.3	0.5	0.4	-0.2	-0.7	0.7	0.3
Time in open arm after self-admin	1.1	1.2	2.5	1.6	0.4	1.2	-1.0	-1.0
Bone: periosteal estimation	5.5	11.3	22.0	-4.5	-4.7	-3.0	2.3	0.1
Bone: periosteal perimeter	3.7	6.2	10.6	-3.3	-3.2	-2.7	1.6	0.3
Bone: post-yield work	0.8	1.0	2.0	-1.3	-1.4	-0.6	0.6	-0.8
Progressive ratio test 1 active lever presses	1.0	1.0	2.7	-1.7	-1.2	-0.1	-0.6	-0.7
Progressive ratio test 1 breakpoint	1.2	1.2	2.6	-1.6	-1.3	0.1	-0.8	-1.1
Progressive ratio test 1 inactive lever presses	1.0	1.1	3.1	-1.8	-0.9	0.0	-0.8	-1.0
Progressive ratio test 2 active lever presses	1.1	1.1	3.1	-1.5	-1.8	-0.1	0.0	-0.5
Progressive ratio test 2 breakpoint	1.4	1.6	4.3	-1.7	-2.1	-0.2	0.3	-0.7
Progressive ratio test 2 inactive lever presses	0.6	0.6	1.3	-1.0	-1.1	0.2	-0.7	-0.5
Incentive Sensitization - Responses	0.9	0.9	1.9	-1.2	-1.4	0.0	0.6	-0.7
Incentive Sensitization - Breakpoint	0.9	0.9	1.9	-1.3	-1.4	0.0	0.7	-0.7
Sum of active levers in priming session hrs 5-6	1.7	1.6	2.8	0.7	1.5	1.7	-0.7	-1.4
Progressive ratio	0.1	0.1	0.2	0.2	0.3	0.2	0.4	-0.0
Food seeking constrained by brief footshock	1.4	1.7	4.2	-1.5	-0.9	0.8	0.9	-2.0
Seeking ratio, punishment vs. effort	0.5	0.6	1.1	-1.0	-0.8	0.1	0.1	-1.0
Retroperitoneal fat weight	0.2	0.6	1.5	-0.9	-1.2	-0.0	-0.4	-0.6
Reaction time number correct	0.5	0.7	1.0	0.9	0.8	-0.3	-1.0	0.9
Reaction time mean minus median	0.1	0.2	0.5	0.7	-0.2	-0.1	0.6	0.2
Reaction time mean minus median AUC	0.2	0.3	0.7	0.8	0.7	0.0	-0.1	0.7
Reaction time num false alarms	1.0	1.3	3.9	-2.0	-1.2	-0.6	0.1	-0.9
Reaction time num false alarms AUC	1.1	1.5	4.7	-2.2	-1.4	-0.7	0.5	-0.6
Reaction time trials correct on left	0.5	0.7	1.0	0.9	0.8	-0.3	-1.0	0.9
Reaction time trials on left	0.5	0.7	1.0	0.9	0.7	-0.4	-0.9	1.0
Reaction time mean	0.4	0.6	1.5	-0.1	-0.1	-0.8	1.2	1.0
Reaction time mean AUC	0.4	0.6	1.6	-0.0	0.0	-0.6	1.3	0.8
Median of all reaction times	0.5	0.7	1.4	-0.3	-0.1	-0.9	1.2	1.0
Reaction time omissions	1.4	1.9	3.0	-0.2	-1.6	-1.6	1.2	1.7
Reaction time false alarm rate	1.5	2.1	5.5	-2.3	-1.6	-0.6	1.1	-1.0
Reaction time premature initiation rate	0.2	0.3	0.8	-0.1	-0.9	0.3	-0.8	-0.1
Reaction time premature initiations	0.3	0.4	1.8	0.4	-0.3	0.3	-1.3	0.2
Std. dev. reaction times	0.4	0.5	1.9	0.3	-0.3	-0.5	1.4	0.7
Reaction time trials completed	0.5	0.7	1.0	0.9	0.7	-0.4	-0.9	1.0
Reaction time trials AUC	0.5	0.7	1.0	0.9	0.8	-0.3	-1.0	0.9
Run reversals in cocaine runway, females	1.0	1.0	1.8	1.3	-0.8	-0.9	0.3	1.3
Run reversals in cocaine runway, males	0.3	0.3	0.8	0.2	-0.5	-0.9	0.3	0.6
Latency to leave start box in cocaine runway	0.0	0.1	0.1	0.3	0.0	-0.3	0.0	0.3
Latency to leave start box in cocaine runway, F	0.3	0.4	1.2	0.2	-0.1	-1.1	-0.1	0.7
Latency to leave start box in cocaine runway, M	0.3	0.3	0.7	0.1	0.4	0.8	0.5	-0.4
Std. dev. time between licks in bursts	0.3	0.3	0.6	0.8	0.3	0.6	-0.6	-0.4
Total sessions with >9 infusions	1.0	1.1	4.4	0.1	0.7	0.6	-2.1	-0.2
Short access day 1 total inactive lever presses	0.7	0.8	1.4	-1.1	-1.1	-1.2	-0.1	0.4
Short access day 10 total inactive lever presses	0.0	0.1	0.1	0.1	-0.2	-0.4	-0.2	-0.2
Short access day 1 total infusions	1.1	1.1	4.2	-0.3	0.5	0.7	-2.1	-0.7
Short access day 10 total infusions	0.9	1.0	1.7	-1.3	-1.3	-0.3	-0.8	-0.9
Short access total infusions	0.7	0.8	1.9	-1.4	-0.8	-0.1	-1.0	-0.8
Short access day 1 locomotion	1.1	1.2	4.1	-0.3	-0.9	0.5	-2.0	-0.8
Short access day 10 total locomotion	2.2	2.4	4.9	-1.9	-2.2	0.3	-0.6	-1.9
Short access total locomotion	1.5	1.5	2.7	-1.0	-1.2	0.5	-1.6	-1.5
One hour access (0.3 mA shock)	0.3	0.4	1.3	-0.7	-0.4	0.3	-0.0	-1.1
Compulsive drug intake	0.7	0.7	1.6	-0.0	-0.1	-1.2	0.7	1.3
One hour access (shock baseline)	0.8	0.9	2.7	-0.4	0.0	1.0	-0.7	-1.6
Social response proportion	0.5	0.6	1.5	1.2	0.5	0.4	-0.8	-0.4
Social responses	0.3	0.3	0.7	0.1	0.4	0.5	-0.8	-0.7
Social time	0.3	0.3	0.9	0.3	-0.9	-0.3	0.7	-0.3
Soleus weight	0.0	0.1	0.2	-0.3	-0.4	-0.4	-0.5	-0.2
Bone: stiffness	0.2	0.3	1.0	-1.0	-0.2	-0.2	-0.6	-0.3
Tibialis anterior weight	1.4	4.8	7.3	2.3	1.3	2.7	-2.1	-2.3
Time to tail flick, vehicle, before self-admin	2.0	2.0	3.5	-0.5	-1.2	-1.9	1.8	1.4
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.2	-0.1	-0.5	0.1	0.1	0.1
Time to tail flick, test, before self-admin	0.3	0.3	0.6	0.8	0.2	0.3	0.8	-0.2
Time to tail flick, test, after self-admin	0.3	0.3	0.6	0.1	-0.4	-0.7	0.2	0.8
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	-0.5	-0.4	0.8	-0.2	-0.5
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.4	0.3	-0.2	-0.2	0.4
Tibia length	0.4	1.2	2.5	-0.8	-0.3	-1.6	-0.6	1.6
Ambulatory time before self-admin	0.2	0.2	0.5	-0.2	-0.1	-0.7	0.6	-0.2
Ambulatory time after self-admin	0.3	0.4	0.9	-0.7	-0.5	-0.9	0.3	-0.3
Bone: tissue strength	0.5	0.4	1.0	0.6	1.0	0.0	-0.8	0.5
Total heroin consumption	1.1	1.3	3.0	-1.7	-1.1	-1.1	1.1	0.1
Bone: trabecular number	4.7	7.3	9.5	-3.1	-2.9	-3.0	2.2	2.3
Bone: trabecular spacing	3.3	4.2	6.2	1.7	2.1	2.5	-1.4	-2.4
Bone: trabecular thickness	6.1	7.3	10.8	-2.1	-3.3	-3.2	2.2	2.5
Bone: trabecular tissue density	1.1	1.6	3.9	1.0	0.4	-0.7	-1.5	2.0
Water consumed over 24 hours	0.1	0.1	0.4	-0.1	-0.3	-0.4	-0.4	0.6
Number of responses in last shaping day	0.7	0.7	2.0	-0.7	-1.4	-1.1	-0.1	0.1