Hub : Genes

Psmb9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr20_4670788_4672059 0.08 0.04 2.4e-04 0.01 0.02 0.02 0.02 9.5e-03 1.4e-03 3.3e-03 1.5e-03
2 Liver intron excision ratio chr20_4669110_4670721 0.07 0.04 7.9e-04 0.03 0.02 0.01 0.02 2.8e-04 2.6e-03 1.3e-02 1.3e-03
3 Adipose mRNA stability Psmb9 0.03 0.02 9.5e-04 0.02 0.03 0.02 0.03 5.5e-03 3.4e-04 1.3e-03 5.9e-04
4 Liver gene expression Psmb9 0.36 0.1 0.0e+00 0.43 0.42 0.43 0.43 2.5e-51 1.4e-50 1.9e-51 1.6e-51
5 LHb gene expression Psmb9 0.2 0.1 3.3e-04 0.04 0.14 0.12 0.11 4.4e-02 4.4e-04 1.2e-03 1.4e-03
6 PL gene expression Psmb9 0.14 0.06 1.2e-15 0.13 0.14 0.12 0.13 1.9e-14 1.2e-14 2.2e-13 1.4e-13
7 IC gene expression Psmb9 0.17 0.08 9.0e-06 0.09 0.1 0.07 0.09 2.0e-04 3.8e-05 4.7e-04 2.1e-04
8 BLA gene expression Psmb9 0.25 0.09 3.5e-12 0.2 0.22 0.19 0.22 8.5e-11 6.5e-12 2.6e-10 8.7e-12
9 Brain gene expression Psmb9 0.16 0.07 5.7e-13 0.16 0.14 0.15 0.15 1.1e-14 1.9e-13 3.6e-14 3.6e-14
10 pVTA gene expression Psmb9 0.2 0.08 2.8e-14 0.14 0.16 0.16 0.16 1.4e-11 3.2e-13 4.6e-13 1.0e-12
11 RMTg gene expression Psmb9 0.15 0.09 4.3e-03 0.06 0.02 -0.01 0 1.1e-02 7.8e-02 6.3e-01 2.8e-01
12 NAcc gene expression Psmb9 0.33 0.21 0.0e+00 0.2 0.19 0.21 0.21 3.1e-30 3.8e-28 1.8e-30 1.7e-30
13 Adipose gene expression Psmb9 0.12 0.06 5.0e-10 0.05 0.08 0.1 0.07 1.2e-06 3.2e-09 4.0e-11 1.4e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.71.35.01.9-1.8-1.22.2-1.4-0.4-0.3-0.3-0.10.60.2-0.10.6
Area under the delay curve0.30.30.8-0.80.60.7-0.50.90.70.60.60.50.20.50.40.1
BMI with tail0.30.94.12.0-1.21.5-1.70.70.30.1-0.20.3-0.2-0.20.5-0.3
BMI without tail0.92.98.10.4-0.42.8-2.62.61.81.71.61.50.91.21.50.1
Body weight0.62.716.4-0.51.12.7-4.12.10.50.3-0.0-0.1-1.2-0.5-0.0-1.9
Weight adjusted by age0.71.04.4-1.31.10.9-2.10.70.1-0.2-0.3-0.9-1.0-0.4-0.9-1.2
Bone surface0.20.40.8-0.40.5-0.50.5-0.5-0.7-0.6-0.6-0.9-0.5-0.6-0.8-0.9
Bone volume0.10.20.90.7-0.6-0.40.9-0.4-0.3-0.2-0.2-0.20.1-0.0-0.2-0.3
Breakpoint value in progressive ratio session0.10.10.2-0.30.3-0.40.4-0.3-0.4-0.3-0.2-0.1-0.1-0.30.00.1
Number of licking bursts0.81.32.6-1.61.6-1.00.4-0.7-1.3-1.1-1.0-1.1-1.1-1.2-0.9-1.0
Context. condit. distance diff. score5.66.812.9-1.11.6-3.62.9-3.3-3.2-3.0-2.8-2.5-2.2-2.5-2.5-1.4
Locomotion velocity, session 10.40.41.5-1.20.7-1.11.2-0.6-0.2-0.2-0.10.20.0-0.10.20.0
Locomotion distance, session 10.50.62.31.1-1.0-1.01.5-1.1-0.4-0.3-0.20.10.40.00.11.1
Locomotion velocity, session 20.20.20.6-0.50.5-0.70.8-0.4-0.6-0.4-0.3-0.2-0.2-0.4-0.2-0.2
Locomotion distance, session 20.81.23.10.7-0.3-1.61.2-1.8-1.3-1.3-1.3-0.8-0.8-0.9-0.9-0.2
Locomotion velocity, session 31.11.21.80.5-0.81.0-0.21.11.21.31.31.31.31.21.31.3
Locomotion distance, session 30.50.62.20.8-0.8-1.01.5-0.9-0.3-0.1-0.00.30.50.20.31.1
Stereotopy head waving bouts, day 30.91.03.0-1.71.60.6-1.70.7-0.2-0.2-0.3-0.9-0.9-0.6-0.8-1.1
Stereotopy head waving duration, day 30.70.82.7-1.61.30.9-1.61.20.50.40.40.0-0.20.10.1-0.5
Locomotion velocity, session 72.83.18.91.4-0.9-2.72.6-3.0-1.8-1.9-1.8-1.0-0.9-1.2-1.0-0.3
Locomotion distance, session 71.72.17.91.1-1.2-2.62.8-2.5-1.1-1.1-1.0-0.40.0-0.3-0.40.4
Stereotopy head waving bouts, day 72.02.34.6-1.10.41.3-0.41.91.61.71.92.11.51.42.11.1
Stereotopy head waving duration, day 71.31.63.1-0.80.31.4-1.01.81.41.41.51.51.01.11.50.9
Locomotion velocity, session 83.23.87.8-2.72.8-1.90.8-1.4-2.1-2.0-1.8-1.7-2.0-2.0-1.7-1.6
Locomotion distance, session 85.88.415.9-0.31.1-4.02.9-4.0-3.6-3.5-3.3-2.7-2.5-2.9-2.8-1.4
Degree of sensitization distance1.21.22.4-1.01.1-0.90.2-0.9-1.1-1.1-1.1-1.3-1.2-1.1-1.2-1.5
Degree of sensitization stereotypy1.81.94.6-0.5-0.10.70.71.31.31.51.62.11.61.42.11.4
Conditioned locomotion0.91.12.0-0.40.9-0.0-0.7-0.3-1.0-1.0-1.1-1.4-1.3-1.2-1.4-1.4
Cocaine response after cond. corrected1.92.34.00.60.1-1.30.2-1.8-1.9-1.9-2.0-1.7-1.7-1.8-1.7-1.4
Cocaine response after cond. not corrected1.21.42.5-0.91.2-0.4-0.8-0.5-1.2-1.2-1.3-1.3-1.5-1.5-1.3-1.6
Cocaine response before conditioning2.53.08.0-2.41.82.3-2.32.81.61.61.70.90.61.00.9-0.1
Saline control response4.76.210.91.0-1.53.3-2.23.13.13.02.82.42.32.62.41.4
Bone: connectivity density1.01.53.51.4-1.0-1.51.8-1.9-1.2-1.1-1.2-1.2-0.5-0.7-1.2-0.2
Bone: cortical apparent density1.01.42.71.6-1.41.7-1.31.21.21.21.01.00.91.00.90.4
Bone: cortical area0.10.10.3-0.50.60.4-0.20.50.00.10.10.2-0.1-0.10.1-0.4
Bone: cortical porosity2.93.15.3-1.50.51.00.21.92.02.02.22.21.91.92.31.8
Bone: cortical porosity1.71.84.2-2.01.10.60.11.41.41.41.61.51.21.31.61.2
Bone: cortical thickness1.42.33.71.6-1.61.6-0.31.41.51.61.51.91.61.51.81.2
Bone: cortical thickness2.12.53.91.9-2.02.0-1.11.61.61.61.51.61.51.51.51.0
Bone: cortical tissue density0.91.22.61.5-1.31.6-1.31.21.21.11.00.80.80.90.80.3
Condit. Reinf. active minus inactive responses0.40.40.9-0.3-0.2-0.10.60.20.80.70.80.70.91.00.70.5
Condit. Reinf. active-inactive response ratio1.11.21.90.2-0.61.2-0.71.21.41.31.31.11.21.31.00.9
Condit. Reinf. active responses0.20.20.60.4-0.8-0.40.7-0.40.40.30.30.30.60.60.30.2
Condit. Reinf. inactive responses0.70.82.81.7-1.6-1.01.5-1.2-0.2-0.2-0.20.10.50.2-0.00.4
Incentive salience index mean0.91.12.9-0.70.7-1.71.6-1.4-1.1-1.1-0.9-0.8-0.6-0.7-0.8-0.6
Condit. Reinf. lever presses4.56.310.7-0.71.4-3.32.3-3.2-3.1-3.0-2.9-2.4-2.3-2.6-2.5-1.6
Condit. Reinf. active minus inactive responses0.50.61.5-1.10.71.0-0.91.20.90.80.80.40.30.60.4-0.3
Condit. Reinf. active-inactive response ratio0.60.73.2-1.81.40.6-1.10.90.30.20.3-0.1-0.3-0.1-0.1-1.1
Condit. Reinf. active responses0.20.30.7-0.40.10.6-0.40.80.80.80.80.50.60.70.50.3
Condit. Reinf. inactive responses0.50.61.01.0-1.00.6-0.10.50.70.80.70.80.90.80.71.0
Condit. Reinf. lever presses0.40.51.0-0.2-0.2-0.21.00.20.70.80.90.91.00.90.90.9
Condit. Reinf. lever reinforcers received0.30.40.8-0.60.20.6-0.20.80.80.80.90.70.70.70.60.3
Conditioned reinforcement - actives0.10.10.40.6-0.6-0.10.1-0.20.20.10.10.20.30.30.20.0
Conditioned reinforcement - inactives0.10.10.30.2-0.40.1-0.30.10.50.30.30.50.30.40.50.1
Conditioned locomotion0.10.10.3-0.20.1-0.50.2-0.5-0.2-0.3-0.3-0.4-0.3-0.1-0.4-0.4
Patch foraging indifference point 0 sec2.03.76.80.7-1.12.6-2.42.42.42.12.02.11.51.81.90.5
Patch foraging indifference point AUC0.40.61.5-1.00.40.9-0.81.20.80.91.00.50.60.60.40.5
Delay disc. indifference point, 0s delay0.60.61.3-0.81.0-0.60.0-0.6-0.8-0.9-0.9-0.6-1.0-0.9-0.6-1.1
Delay disc. indifference point, 16s delay0.70.81.30.4-0.60.90.00.91.11.11.10.91.01.10.81.0
Delay disc. indifference point, 2s delay0.60.63.7-1.91.50.3-0.90.60.20.10.10.0-0.5-0.1-0.0-0.6
Delay disc. indifference point, 24s delay1.31.42.6-0.80.21.3-0.91.61.61.41.51.10.91.31.20.8
Delay disc. indifference point, 4s delay0.80.92.3-1.10.91.3-1.41.50.90.80.80.70.10.40.7-0.1
Delay disc. indifference point, 8s delay0.10.10.3-0.40.20.30.00.50.50.40.40.40.20.40.30.2
Indifference point function ln k0.20.30.9-0.90.9-0.70.7-0.4-0.6-0.5-0.4-0.2-0.4-0.4-0.3-0.7
Indifference point function log k0.20.30.9-0.90.9-0.70.7-0.4-0.6-0.5-0.4-0.2-0.4-0.4-0.3-0.7
Patch foraging total patch changes 0 sec2.14.07.20.9-1.22.7-2.42.52.52.22.12.21.61.92.10.6
Patch foraging total patch changes 12 sec2.02.64.90.5-0.92.2-1.92.12.01.91.81.41.41.51.21.1
Patch foraging total patch changes 18 sec1.82.85.62.4-2.32.0-1.61.41.71.61.41.51.51.41.31.2
Patch foraging total patch changes 24 sec1.32.25.42.1-2.31.0-0.10.71.51.41.31.41.71.51.41.4
Patch foraging total patch changes 6 sec2.23.45.41.0-1.42.3-1.72.12.32.11.92.11.61.81.91.0
Patch foraging time to switch 0 sec0.51.04.22.1-1.1-0.2-0.2-1.0-0.9-1.0-1.2-1.0-0.8-0.8-1.1-0.2
Patch foraging water rate 0 sec0.10.21.5-0.50.30.6-1.20.60.40.20.20.2-0.10.00.2-0.4
Patch foraging water rate 12 sec0.30.71.41.1-1.20.40.10.30.70.70.71.20.90.81.00.8
Patch foraging water rate 18 sec0.20.30.70.3-0.40.8-0.70.70.60.60.50.40.30.50.40.4
Patch foraging water rate 24 sec0.30.40.70.7-0.70.6-0.50.50.60.60.60.80.60.60.60.6
Patch foraging water rate 6 sec0.20.20.50.7-0.70.6-0.60.40.40.40.30.50.40.30.40.5
Seeking ratio, delayed vs. immediate footshock2.32.86.8-0.4-0.02.3-1.82.61.72.02.01.51.51.41.41.2
Distance traveled before self-admin0.81.11.90.10.5-0.5-0.3-0.8-1.4-1.3-1.3-1.3-1.3-1.3-1.3-0.9
Distance traveled after self-admin0.50.62.7-0.70.71.3-1.61.30.30.40.4-0.1-0.2-0.0-0.3-0.6
Extensor digitorum longus weight0.41.42.1-1.01.3-1.00.0-0.9-1.3-1.3-1.3-1.4-1.4-1.3-1.4-1.0
Bone: elastic displacement1.31.52.80.4-0.90.80.30.91.51.41.41.71.41.51.71.1
Bone: elastic work0.30.30.9-0.0-0.10.6-0.10.70.70.60.61.00.40.51.00.2
Bone: endosteal estimation2.35.014.2-3.63.80.1-2.10.4-1.3-1.4-1.4-2.2-2.5-2.0-2.0-3.0
Bone: endosteal perimeter2.55.411.0-2.93.3-1.3-0.4-1.1-2.3-2.2-2.2-2.5-2.7-2.5-2.4-2.7
Epididymis fat weight2.99.837.66.1-5.33.3-1.91.82.62.41.92.72.42.22.61.6
Delta time in closed arm before/after self-admin0.50.41.4-0.20.5-0.1-0.6-0.4-0.6-0.7-0.8-0.1-1.0-0.9-0.2-1.2
Delta time in open arm before/after self-admin0.30.30.80.5-0.70.40.10.40.70.70.70.40.80.90.00.4
Diff in mean of infusions in LGA sessions1.51.94.00.6-0.1-1.91.7-2.0-1.7-1.5-1.5-1.5-0.9-1.1-1.4-0.3
Delay discount exponential model param0.50.51.20.9-0.6-0.80.6-1.1-0.9-0.7-0.8-0.7-0.3-0.6-0.6-0.2
Extinction: sum of active levers before priming0.90.91.3-0.91.0-1.00.3-1.0-1.1-1.1-1.1-1.1-1.0-1.0-1.0-0.8
Active lever presses in extinction session 60.20.20.50.7-0.7-0.30.5-0.50.20.00.00.50.20.20.70.4
Bone: final force0.50.73.80.8-0.51.6-2.01.10.50.40.20.4-0.20.10.4-0.5
Bone: final moment0.40.62.80.7-0.41.4-1.71.00.60.40.30.4-0.10.10.4-0.4
Food consumed during 24 hour testing period1.21.73.2-0.41.0-0.4-0.9-0.7-1.4-1.4-1.6-1.5-1.8-1.7-1.4-1.6
Glucose4.47.013.4-3.73.6-2.60.3-2.1-2.5-2.7-2.5-2.8-2.8-2.6-2.7-2.2
Heart weight0.91.43.3-1.81.21.5-1.61.81.31.01.00.60.20.70.7-0.7
Delay discount hyperbolic model param0.60.61.41.1-0.7-0.90.6-1.2-0.9-0.8-0.9-0.8-0.4-0.7-0.7-0.2
Intermittent access intake day 1-15 change0.10.30.7-0.20.00.7-0.30.80.50.60.70.50.60.50.60.2
Intermittent access intake escalation0.91.82.70.4-0.71.4-0.51.61.51.61.61.51.51.41.51.0
Intermittent access intake escalation 20.10.20.4-0.60.30.30.20.50.40.40.50.50.40.30.60.1
Intermitt. access day 1 inactive lever presses0.72.64.1-1.31.7-1.1-0.5-1.1-1.9-1.8-1.8-1.5-1.9-2.0-1.3-2.0
Intermitt. access day 15 inactive lever presses0.10.10.8-0.40.40.3-0.90.3-0.0-0.1-0.1-0.1-0.3-0.2-0.0-0.6
Intermitt. access escalation Index1.21.83.40.10.4-1.71.5-1.7-1.8-1.6-1.5-1.2-1.0-1.4-1.3-0.6
Intermittent access day 1 total infusions0.40.62.60.3-0.6-1.51.6-1.4-0.1-0.4-0.30.10.10.20.10.4
Intermittent access day 15 total infusions0.60.91.50.6-1.00.20.50.31.11.01.01.21.21.21.21.0
Intermittent access terminal intake (last 3 days)0.60.81.50.2-0.70.30.10.51.21.01.11.21.11.21.20.8
Intermittent access total infusions0.40.50.90.4-0.8-0.20.6-0.10.90.70.70.90.90.90.90.8
Intermittent access day 1 locomotion0.10.20.60.8-0.8-0.50.4-0.60.1-0.1-0.1-0.00.20.20.00.3
Intermittent access day 15 total locomotion0.10.31.00.1-0.10.9-1.00.70.60.50.40.20.10.40.30.1
Intermittent access total locomotion0.30.40.70.6-0.70.6-0.20.50.90.70.70.50.60.80.60.6
Intermittent access standard deviation0.81.64.10.5-0.61.9-2.01.71.51.31.21.10.81.11.10.1
Left kidney weight0.73.212.00.30.13.4-3.52.91.61.51.31.00.30.81.1-0.3
Right kidney weight0.52.212.50.40.22.9-3.52.20.90.80.50.3-0.40.20.4-0.9
Cocaine induced anxiety0.60.91.6-0.30.6-0.7-0.0-0.7-1.3-1.1-1.1-1.2-1.0-1.2-1.2-0.8
Post-drug Anxiety0.20.30.5-0.30.50.1-0.50.0-0.6-0.5-0.5-0.7-0.6-0.6-0.7-0.5
Baseline Anxiety0.10.20.3-0.20.00.6-0.50.60.50.50.40.20.20.40.2-0.2
Tail length1.14.215.2-3.93.32.1-3.32.70.90.90.90.2-0.60.10.2-1.7
Length with tail1.14.814.5-3.63.52.0-3.82.20.2-0.1-0.1-0.8-1.7-0.8-0.8-2.9
Length without tail1.44.611.6-1.32.20.8-3.10.1-1.4-1.7-2.0-2.1-3.0-2.3-1.9-3.4
Times rat made contact with spout3.03.45.21.4-1.91.00.51.21.92.02.02.22.32.22.12.3
Lifetime Intake0.30.40.70.3-0.7-0.10.3-0.10.80.60.60.80.70.80.80.7
Liver weight, left1.82.96.1-2.12.5-0.2-1.6-0.2-1.5-1.5-1.5-1.9-2.1-1.9-1.8-1.6
Liver weight, right2.34.08.6-2.82.9-0.6-1.2-0.4-1.6-1.7-1.7-2.1-2.3-1.9-2.0-2.8
Locomotor activity0.81.33.3-1.61.41.4-1.61.80.70.91.00.70.30.50.80.5
Locomotor testing distance0.20.41.5-1.01.20.7-1.20.8-0.10.10.1-0.0-0.3-0.1-0.10.0
Locomotor testing rearing0.30.62.0-0.71.10.4-1.40.3-0.6-0.6-0.6-0.6-1.0-0.7-0.8-0.9
Locomotion in novel chamber0.10.10.20.4-0.30.40.20.30.20.30.20.20.20.20.20.4
Locomotion in novel chamber post-restriction0.20.41.80.4-0.31.1-1.30.80.60.40.30.30.10.40.0-0.1
Fecal boli incidents, locomotor time 10.50.71.90.7-0.5-1.20.8-1.4-0.8-0.9-0.9-0.6-0.5-0.6-0.7-0.5
Change in fecal boli incidents, locomotor task1.11.13.2-1.71.80.4-1.50.5-0.5-0.5-0.5-0.9-1.1-0.9-0.8-1.2
Time >=10cm from walls, locomotor time 12.42.54.7-0.81.50.2-2.2-0.2-1.4-1.5-1.6-1.7-2.1-1.9-2.1-1.8
Bouts of movement, locomotor time 10.10.10.60.1-0.1-0.20.7-0.1-0.10.10.20.20.30.20.20.3
Total resting periods, locomotor time 10.10.10.4-0.10.1-0.40.6-0.2-0.2-0.10.0-0.10.10.0-0.10.1
Rest time, locomotor task time 10.10.20.5-0.70.6-0.50.6-0.2-0.4-0.3-0.20.2-0.3-0.30.2-0.5
Distance moved, locomotor task time 10.20.31.30.1-0.10.9-1.20.80.50.50.4-0.10.10.3-0.20.3
Vertical activity count, locomotor time 10.30.72.80.7-0.61.4-1.71.00.90.70.50.10.20.50.10.5
Time >=10cm from walls, locomotor time 20.91.34.8-1.41.50.6-2.20.4-0.3-0.6-0.6-1.2-1.4-0.8-1.1-1.0
Bouts of movement, locomotor time 20.40.61.2-0.70.30.8-0.31.10.80.91.00.80.70.80.80.6
Total resting periods, locomotor time 20.30.61.5-1.20.70.50.11.00.60.80.90.70.60.70.70.5
Rest time, locomotor task time 22.12.74.3-0.91.4-1.50.7-1.5-2.1-1.9-1.9-1.6-1.8-2.0-1.6-1.7
Distance moved, locomotor task time 20.50.61.30.9-0.91.1-1.10.71.00.80.60.20.40.80.20.8
Vertical activity count, locomotor time 20.30.41.60.5-0.41.0-1.30.60.80.50.4-0.00.10.50.10.4
Light reinforcement 10.30.61.90.9-0.10.4-1.4-0.1-0.7-0.7-0.8-1.0-0.9-0.8-1.1-0.4
Light reinforcement 20.71.02.10.20.4-0.3-0.9-0.7-1.2-1.2-1.4-1.0-1.5-1.4-1.1-1.0
Bone: marrow area2.24.813.8-3.53.70.3-2.20.5-1.2-1.3-1.3-2.1-2.4-1.9-2.0-2.9
Bone: maximum diameter1.52.86.0-2.32.4-1.30.5-0.9-1.6-1.6-1.5-1.7-1.7-1.6-1.7-1.8
Bone: maximum force0.20.31.90.3-0.11.0-1.40.60.20.1-0.10.1-0.4-0.20.0-0.7
Bone: maximum moment0.10.21.20.10.10.7-1.10.50.20.0-0.10.0-0.4-0.20.0-0.7
Mean time between licks in bursts1.22.85.2-2.32.2-1.80.9-1.3-1.8-1.6-1.5-1.8-1.5-1.6-1.6-1.4
Mean num. licks in bursts2.64.05.82.1-2.41.6-0.21.42.32.12.12.22.22.32.02.2
Cd content in liver1.11.22.61.5-1.1-0.90.2-1.6-0.8-1.1-1.3-1.2-0.9-1.0-1.2-0.1
Co content in liver0.40.42.21.0-0.81.0-1.50.40.40.20.0-0.0-0.10.10.00.2
Cu content in liver1.82.14.51.7-2.10.60.70.61.31.41.41.41.81.61.41.8
Fe content in liver0.30.41.51.2-1.20.7-0.50.40.50.50.40.40.40.40.40.4
K content in liver0.60.61.30.3-0.2-1.11.1-1.1-0.9-0.7-0.7-0.6-0.3-0.6-0.60.8
Mg content in liver2.52.54.3-1.11.6-1.91.1-1.7-2.1-1.8-1.7-1.7-1.5-1.7-1.6-0.4
Mn content in liver4.95.47.4-1.82.5-2.10.5-2.0-2.7-2.6-2.5-2.7-2.6-2.5-2.7-1.9
Na content in liver1.01.02.20.5-0.80.80.01.00.91.11.21.21.21.01.21.5
Rb content in liver0.91.02.00.3-0.0-1.20.5-1.4-1.1-1.2-1.2-1.1-1.0-1.0-1.1-0.6
Se content in liver1.21.46.4-2.52.3-1.10.4-0.5-1.0-0.9-0.6-0.8-0.9-0.9-0.7-0.5
Sr content in liver0.60.50.9-0.60.8-0.6-0.1-0.6-0.7-0.8-0.8-0.8-0.9-0.9-0.7-0.1
Zn content in liver0.91.02.2-0.50.6-0.9-0.1-1.0-1.0-1.1-1.1-1.5-1.1-1.0-1.5-0.6
Bone: minimum diameter1.93.47.0-2.32.7-0.8-0.4-0.7-1.8-1.7-1.7-1.9-2.2-2.0-1.9-2.4
Time in familiar zone, hab. session 13.02.95.82.0-2.40.21.60.31.51.51.61.62.22.01.62.2
Time in novel zone, hab. session 11.61.64.1-1.82.00.3-1.70.3-0.8-0.9-0.9-1.0-1.5-1.3-1.0-1.5
Total zone transitions, hab. session 10.20.20.90.10.0-0.80.9-0.6-0.6-0.4-0.4-0.0-0.0-0.30.00.7
Total locomotion distance, hab. session 10.30.51.40.4-0.1-1.01.2-1.0-0.9-0.7-0.7-0.4-0.3-0.5-0.40.4
Locomotion velocity, hab. session 10.10.20.80.2-0.0-0.70.9-0.6-0.6-0.4-0.4-0.1-0.1-0.3-0.10.5
Time in familiar zone, hab. session 21.11.22.11.2-1.21.1-0.51.00.91.21.10.91.31.10.81.5
Time in novel zone, hab. session 20.10.10.6-0.80.6-0.1-0.3-0.00.2-0.1-0.1-0.1-0.4-0.1-0.0-0.7
Total zone transitions, hab. session 20.30.41.00.8-0.2-0.50.3-0.7-1.0-0.7-0.8-0.7-0.5-0.7-0.70.0
Total locomotion distance, hab. session 21.11.42.81.2-0.5-1.41.2-1.7-1.6-1.4-1.4-1.0-0.7-1.1-1.1-0.0
Locomotion velocity, hab. session 21.31.83.61.0-0.3-1.71.5-1.9-1.8-1.6-1.5-1.1-0.9-1.3-1.2-0.1
Novel to familiar place preference ratio0.10.10.1-0.3-0.0-0.20.20.00.30.20.30.30.30.30.30.1
Novelty place preference0.10.10.3-0.60.20.0-0.10.30.50.40.40.40.30.40.40.1
Time in novel zone, NPP test0.20.20.5-0.70.20.2-0.10.50.60.50.60.50.40.60.50.1
Total zone transitions, NPP test1.11.64.00.6-0.2-1.91.9-2.0-1.5-1.4-1.3-0.9-0.6-1.0-0.90.2
Total locomotion distance, NPP test1.92.56.41.3-0.6-2.21.9-2.5-1.8-1.8-1.8-1.3-1.1-1.3-1.3-0.2
Locomotion velocity, NPP test2.43.48.61.5-0.7-2.62.2-2.9-2.1-2.1-2.1-1.4-1.2-1.6-1.4-0.1
Intraocular pressure0.30.52.01.4-1.4-0.00.4-0.30.30.30.3-0.10.70.6-0.10.9
Delta distance traveled before/after self-admin2.32.45.6-1.10.42.0-1.42.41.91.92.01.31.31.51.30.3
Delta ambulatory time before/after self-admin1.51.94.8-1.30.61.8-1.52.21.61.61.60.90.91.21.00.1
Parametrial fat weight0.40.95.42.3-1.41.1-1.50.3-0.0-0.1-0.3-0.1-0.2-0.3-0.2-0.3
Pavlov. Cond. lever latency2.83.58.72.1-2.02.9-2.82.21.91.81.51.01.11.40.90.9
Pavlov. Cond. magazine entry latency0.60.84.0-2.01.4-1.11.7-0.3-0.3-0.10.20.10.10.00.2-0.0
Pavlov. Cond. change in total contacts0.40.42.8-1.71.2-0.60.7-0.0-0.1-0.10.10.2-0.0-0.00.2-0.6
Pavlov. Cond. index score1.92.36.2-2.22.0-2.32.5-1.5-1.4-1.3-1.0-0.7-0.8-1.0-0.6-0.8
Pavlov. Cond. latency score2.02.66.6-2.32.1-2.42.6-1.6-1.5-1.3-1.0-0.7-0.9-1.1-0.6-0.9
Pavlov. Cond. lever contacts3.64.38.9-1.92.0-3.02.4-2.5-2.3-2.3-2.0-1.4-1.7-2.0-1.4-1.4
Pavlov. Cond. magazine entry number0.40.62.51.6-1.11.0-1.50.30.40.2-0.00.1-0.10.00.00.1
Pavlov. Cond. intertrial magazine entries0.70.94.62.1-2.00.3-0.5-0.20.60.40.20.40.60.60.40.8
Pavlov. Cond. lever-magazine prob. diff.1.82.26.5-2.11.8-2.32.5-1.5-1.4-1.3-1.0-0.6-0.8-1.0-0.6-0.8
Pavlov. Cond. response bias1.21.53.5-1.81.6-1.91.9-1.2-1.2-1.0-0.8-0.7-0.7-0.8-0.7-0.7
Pavlov. Cond. lever latency1.11.52.4-0.71.0-0.5-0.7-0.7-1.3-1.3-1.4-1.5-1.5-1.4-1.5-1.5
Pavlov. Cond. magazine entry latency0.20.20.6-0.70.4-0.80.7-0.6-0.4-0.4-0.4-0.3-0.3-0.3-0.2-0.3
Pavlov. Cond. change in total contacts0.81.32.3-0.1-0.40.70.41.11.31.41.41.51.41.31.41.2
Pavlov. Cond. index score0.30.40.6-0.2-0.20.00.80.30.70.60.70.70.80.70.80.7
Pavlov. Cond. latency score0.30.40.7-0.2-0.20.20.60.50.80.70.80.80.80.80.80.7
Pavlov. Cond. lever contacts0.91.32.10.6-0.90.50.60.71.21.21.31.41.41.31.41.4
Pavlov. Cond. magazine entry number0.00.10.20.10.00.4-0.40.40.20.20.20.00.20.1-0.00.2
Pavlov. Cond. intertrial magazine entries0.20.31.0-1.01.0-0.50.2-0.1-0.6-0.3-0.2-0.6-0.2-0.3-0.6-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.30.6-0.2-0.20.00.70.30.60.60.70.70.70.70.80.6
Pavlov. Cond. response bias0.30.41.00.1-0.4-0.21.00.10.60.60.70.90.80.70.90.9
Time in closed arm before self-admin0.10.10.7-0.80.60.00.00.2-0.1-0.0-0.0-0.4-0.2-0.0-0.2-0.1
Time in closed arm after self-admin0.10.10.3-0.20.3-0.30.2-0.4-0.4-0.5-0.50.1-0.5-0.50.2-0.4
Time in open arm before self-admin0.30.30.6-0.70.2-0.30.70.10.40.40.60.70.60.40.70.5
Time in open arm after self-admin0.30.30.7-0.4-0.10.20.30.50.70.80.80.60.80.80.40.3
Bone: periosteal estimation1.02.16.7-2.42.60.6-1.60.8-0.6-0.6-0.6-1.1-1.5-1.1-1.1-2.1
Bone: periosteal perimeter0.71.24.7-2.12.2-0.2-0.50.1-0.8-0.8-0.7-0.7-1.2-1.0-0.6-1.3
Bone: post-yield work2.13.04.4-1.52.0-1.3-0.1-1.3-1.9-1.9-1.9-1.8-2.1-2.0-1.7-1.9
Progressive ratio test 1 active lever presses0.10.10.3-0.1-0.1-0.60.3-0.6-0.0-0.2-0.2-0.2-0.20.0-0.1-0.1
Progressive ratio test 1 breakpoint0.10.10.3-0.2-0.0-0.60.3-0.6-0.0-0.2-0.2-0.2-0.2-0.0-0.1-0.2
Progressive ratio test 1 inactive lever presses0.20.21.61.3-0.9-0.2-0.1-0.6-0.2-0.3-0.4-0.2-0.1-0.1-0.2-0.2
Progressive ratio test 2 active lever presses0.20.20.60.6-0.7-0.50.8-0.50.10.00.10.20.40.30.20.4
Progressive ratio test 2 breakpoint0.20.30.70.6-0.8-0.40.8-0.40.20.20.20.30.50.50.40.6
Progressive ratio test 2 inactive lever presses0.50.81.9-0.70.6-1.40.7-1.3-0.9-1.0-1.0-0.8-0.8-0.8-0.7-0.9
Incentive Sensitization - Responses0.10.10.50.1-0.2-0.40.7-0.2-0.10.10.20.20.40.20.30.4
Incentive Sensitization - Breakpoint0.10.10.60.4-0.4-0.40.8-0.3-0.00.10.20.20.50.20.30.5
Sum of active levers in priming session hrs 5-60.10.10.7-0.80.6-0.40.3-0.10.0-0.00.00.0-0.0-0.10.10.2
Progressive ratio2.23.410.10.6-0.53.2-2.82.91.91.91.71.41.01.21.60.8
Food seeking constrained by brief footshock0.50.61.50.4-0.50.50.10.61.00.90.91.20.80.91.20.7
Seeking ratio, punishment vs. effort0.91.24.5-0.90.6-2.12.1-1.7-0.9-0.9-0.7-0.4-0.3-0.5-0.6-0.3
Retroperitoneal fat weight0.10.51.71.3-0.8-0.3-0.3-0.8-0.7-0.7-0.9-0.5-0.6-0.6-0.3-1.0
Reaction time number correct0.81.52.41.3-1.31.6-1.31.31.41.31.21.21.11.11.30.8
Reaction time mean minus median0.71.93.9-1.21.2-2.01.6-1.6-1.5-1.4-1.2-1.5-1.0-1.2-1.5-0.1
Reaction time mean minus median AUC1.02.56.2-1.11.0-2.51.9-2.2-1.6-1.7-1.5-1.6-1.1-1.2-1.6-0.3
Reaction time num false alarms0.20.31.2-1.11.0-0.0-0.30.3-0.3-0.2-0.1-0.1-0.3-0.3-0.0-0.7
Reaction time num false alarms AUC0.30.42.1-1.51.20.4-0.60.8-0.10.20.30.0-0.1-0.10.1-0.5
Reaction time trials correct on left0.81.52.41.3-1.31.6-1.31.31.41.31.21.21.11.11.30.8
Reaction time trials on left0.81.42.31.2-1.21.5-1.31.21.31.31.11.11.11.01.30.8
Reaction time mean3.04.87.1-1.21.7-2.71.6-2.6-2.5-2.5-2.4-2.3-2.2-2.2-2.3-1.7
Reaction time mean AUC2.64.26.6-1.11.5-2.61.6-2.5-2.3-2.4-2.3-2.1-2.1-2.0-2.1-1.6
Median of all reaction times2.94.15.7-0.91.4-2.31.3-2.4-2.3-2.4-2.3-2.1-2.2-2.1-2.1-1.9
Reaction time omissions1.82.63.9-0.91.3-1.91.2-1.8-2.0-1.9-1.8-1.9-1.5-1.6-1.7-1.0
Reaction time false alarm rate0.70.94.6-2.11.9-0.60.2-0.0-0.8-0.6-0.4-0.6-0.7-0.6-0.5-1.0
Reaction time premature initiation rate0.00.10.20.00.20.1-0.1-0.1-0.2-0.2-0.3-0.4-0.4-0.2-0.4-0.4
Reaction time premature initiations0.20.41.30.7-0.51.1-1.00.80.70.60.50.30.30.50.30.1
Std. dev. reaction times1.32.54.0-2.01.9-2.01.4-1.5-1.6-1.5-1.3-1.6-1.3-1.3-1.6-0.8
Reaction time trials completed0.81.42.31.2-1.21.5-1.31.21.31.31.11.11.11.01.30.8
Reaction time trials AUC0.61.22.01.2-1.21.4-1.31.11.21.11.01.00.90.91.10.7
Run reversals in cocaine runway, females0.20.21.11.0-0.90.10.2-0.10.40.30.20.40.40.50.10.4
Run reversals in cocaine runway, males0.50.51.0-0.70.7-1.01.0-0.8-0.8-0.7-0.6-0.5-0.6-0.6-0.8-0.4
Latency to leave start box in cocaine runway1.82.12.9-0.71.0-1.60.9-1.6-1.7-1.7-1.7-1.4-1.5-1.6-1.5-1.4
Latency to leave start box in cocaine runway, F1.21.42.3-0.40.6-1.50.7-1.5-1.3-1.4-1.4-1.2-1.1-1.2-1.1-1.0
Latency to leave start box in cocaine runway, M0.60.60.9-0.40.7-0.50.4-0.5-0.9-0.9-0.9-0.6-1.0-0.9-0.9-0.9
Std. dev. time between licks in bursts2.94.08.6-2.92.9-1.50.7-1.0-2.0-1.8-1.7-2.2-2.0-2.0-2.0-2.1
Total sessions with >9 infusions0.50.61.3-0.2-0.40.3-0.30.51.10.91.00.90.91.01.00.7
Short access day 1 total inactive lever presses0.50.71.3-1.10.9-1.20.1-1.0-0.7-0.9-0.8-0.4-0.9-0.7-0.4-0.9
Short access day 10 total inactive lever presses0.30.71.70.30.3-0.7-0.0-0.8-1.3-1.0-1.1-0.7-0.8-1.1-0.7-0.7
Short access day 1 total infusions0.10.10.4-0.60.1-0.60.2-0.50.2-0.00.10.00.10.30.00.1
Short access day 10 total infusions0.20.30.60.6-0.8-0.30.2-0.30.50.30.40.70.60.60.70.7
Short access total infusions0.10.10.20.0-0.4-0.50.2-0.40.50.20.20.40.30.50.50.3
Short access day 1 locomotion0.30.41.1-0.00.1-1.10.6-1.0-0.8-0.7-0.6-0.7-0.3-0.5-0.7-0.1
Short access day 10 total locomotion0.71.34.2-1.91.81.1-2.01.2-0.0-0.0-0.0-0.9-0.8-0.5-0.7-1.0
Short access total locomotion0.40.50.9-1.00.9-0.2-0.9-0.2-0.4-0.5-0.5-0.9-0.8-0.6-0.9-0.9
One hour access (0.3 mA shock)0.40.52.10.6-0.4-1.11.5-1.0-0.6-0.4-0.4-0.30.1-0.2-0.30.7
Compulsive drug intake3.94.68.4-0.71.6-1.91.0-1.9-2.9-2.5-2.5-2.7-2.3-2.6-2.6-1.6
One hour access (shock baseline)1.21.82.81.1-1.50.40.50.51.51.31.31.71.61.61.61.7
Social response proportion0.50.61.7-1.31.30.2-1.00.2-0.4-0.5-0.5-0.2-1.0-0.8-0.4-1.1
Social responses0.30.41.4-1.11.00.8-1.21.00.20.20.20.1-0.2-0.1-0.1-0.1
Social time2.23.05.0-1.62.1-1.40.2-1.2-2.2-1.9-1.8-1.8-1.8-2.1-1.9-1.7
Soleus weight3.410.020.1-3.84.5-1.7-0.9-1.5-3.0-3.1-3.0-3.6-3.7-3.2-3.5-3.6
Bone: stiffness0.20.31.41.0-0.70.8-1.20.40.20.1-0.00.1-0.1-0.0-0.0-0.4
Tibialis anterior weight0.20.71.91.4-1.30.9-0.50.70.80.80.70.40.80.80.40.8
Time to tail flick, vehicle, before self-admin0.30.31.01.0-0.4-0.10.3-0.3-0.8-0.5-0.5-0.7-0.2-0.6-0.50.2
Time to tail flick, vehicle, after self-admin0.10.20.5-0.70.6-0.60.4-0.4-0.4-0.4-0.3-0.4-0.2-0.2-0.3-0.3
Time to tail flick, test, before self-admin1.01.02.00.5-0.70.90.11.00.91.11.21.21.31.01.41.4
Time to tail flick, test, after self-admin0.60.73.50.4-0.6-0.81.9-0.40.10.30.50.80.90.40.81.0
Delta time to tail flick, vehicle, before/after SA0.40.31.1-0.1-0.3-0.81.1-0.50.50.20.30.70.50.60.70.3
Delta time to tail flick, test, before/after SA0.60.61.70.8-0.5-1.11.2-1.3-0.8-0.8-0.8-0.4-0.4-0.6-0.5-0.3
Tibia length1.13.18.8-2.53.00.5-2.10.6-1.1-1.0-1.1-1.5-1.9-1.5-1.5-2.5
Ambulatory time before self-admin0.20.30.70.20.1-0.50.2-0.7-0.8-0.7-0.7-0.6-0.6-0.7-0.7-0.4
Ambulatory time after self-admin0.40.51.7-0.80.71.1-1.31.20.40.50.50.20.00.1-0.1-0.7
Bone: tissue strength0.10.10.20.20.0-0.2-0.2-0.4-0.2-0.4-0.4-0.1-0.5-0.4-0.1-0.5
Total heroin consumption0.00.00.1-0.30.40.0-0.20.1-0.2-0.1-0.1-0.1-0.1-0.20.10.0
Bone: trabecular number1.01.75.52.3-2.2-1.32.3-1.6-0.4-0.3-0.30.10.70.30.01.0
Bone: trabecular spacing1.21.65.5-2.12.01.5-2.41.70.60.40.40.2-0.6-0.20.3-1.1
Bone: trabecular thickness0.91.24.22.0-1.8-1.11.8-1.4-0.6-0.5-0.5-0.40.3-0.0-0.50.7
Bone: trabecular tissue density0.60.91.6-1.10.50.7-0.41.21.21.11.30.90.91.11.00.5
Water consumed over 24 hours0.20.30.7-0.80.8-0.3-0.1-0.2-0.6-0.6-0.5-0.7-0.7-0.6-0.6-0.6
Number of responses in last shaping day1.01.16.9-2.62.1-0.1-0.30.4-0.2-0.3-0.2-0.7-0.9-0.5-0.5-1.2