Prr29

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Prr29	0.07	0.03	9.0e-08	0.06	0.05	0.03	0.06	1.2e-07	2.6e-06	5.9e-04	8.2e-07
2	Liver	gene expression	Prr29	0.04	0.02	4.2e-04	0.03	0.01	0.01	0.01	6.2e-04	9.3e-03	5.1e-02	2.4e-02
3	Adipose	intron excision ratio	chr10_91307536_91307649	0.03	0.02	4.8e-04	0.03	0.03	0.02	0.03	3.5e-04	3.6e-04	5.3e-03	7.0e-04
4	PL	gene expression	Prr29	0.06	0.03	4.9e-03	0.01	0.02	0.02	0.02	7.1e-03	1.8e-03	1.0e-03	1.1e-03
5	Liver	mRNA stability	Prr29	0.05	0.03	1.3e-05	0.04	0.05	0.04	0.04	4.3e-05	5.2e-06	2.4e-05	2.4e-05
6	Adipose	gene expression	Prr29	0.25	0.08	2.5e-12	0.11	0.1	0.11	0.1	5.0e-12	1.1e-11	1.3e-12	2.2e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.6	2.6	8.8	-0.4	0.8	0.8	3.0	0.4	-2.4
Area under the delay curve	0.3	0.4	1.7	0.1	0.3	0.4	1.3	0.5	-0.1
BMI with tail	0.2	0.7	2.1	0.1	0.6	0.5	-1.4	-0.0	-1.4
BMI without tail	1.0	2.2	4.1	-1.2	2.0	2.0	-0.2	1.4	-1.1
Body weight	1.5	6.3	9.0	-2.5	3.0	3.0	2.1	2.6	-1.7
Weight adjusted by age	0.8	0.9	3.2	0.7	-0.6	-0.6	-0.9	-0.1	1.8
Bone surface	4.0	7.0	18.7	-2.3	2.3	2.3	4.3	2.0	-1.9
Bone volume	3.3	5.7	15.1	-1.9	2.1	2.1	3.9	1.8	-1.9
Breakpoint value in progressive ratio session	0.9	1.0	2.2	-1.4	0.7	0.9	-0.3	0.8	1.5
Number of licking bursts	0.1	0.1	0.4	0.0	-0.2	-0.2	0.6	-0.0	0.3
Context. condit. distance diff. score	0.2	0.3	1.6	-0.0	-0.2	-0.2	-1.3	-0.1	0.3
Locomotion velocity, session 1	1.5	1.6	4.5	-0.6	0.7	0.7	2.1	0.4	-1.9
Locomotion distance, session 1	0.7	0.9	3.0	0.2	0.1	0.1	1.7	-0.0	-1.5
Locomotion velocity, session 2	0.3	0.4	1.4	-1.2	0.5	0.5	0.4	0.1	0.2
Locomotion distance, session 2	0.2	0.3	1.3	-0.2	0.0	0.0	1.1	-0.2	-0.5
Locomotion velocity, session 3	0.8	0.9	1.4	0.8	-0.9	-0.9	0.6	-1.2	-1.2
Locomotion distance, session 3	0.2	0.2	1.0	0.0	-0.3	-0.3	1.0	-0.4	-0.4
Stereotopy head waving bouts, day 3	0.6	0.7	1.3	1.1	-0.7	-0.7	0.4	-0.8	-1.2
Stereotopy head waving duration, day 3	0.3	0.3	0.8	0.9	-0.6	-0.6	0.2	-0.5	-0.3
Locomotion velocity, session 7	0.6	0.6	1.5	0.6	-0.7	-0.7	0.1	-0.9	-1.2
Locomotion distance, session 7	0.2	0.2	1.0	-0.3	0.2	0.2	-0.4	0.3	1.0
Stereotopy head waving bouts, day 7	0.7	0.8	1.3	0.7	-0.9	-0.9	0.6	-1.1	-0.9
Stereotopy head waving duration, day 7	1.5	1.8	2.9	1.3	-1.7	-1.7	0.4	-1.7	-0.6
Locomotion velocity, session 8	0.4	0.5	0.9	-0.9	0.7	0.7	0.2	0.8	-0.5
Locomotion distance, session 8	0.1	0.1	0.2	-0.5	0.2	0.2	-0.3	0.2	0.3
Degree of sensitization distance	0.8	0.8	1.5	-0.6	0.9	0.9	-0.5	1.2	1.1
Degree of sensitization stereotypy	1.1	1.2	2.6	0.8	-1.2	-1.2	0.2	-1.6	-0.9
Conditioned locomotion	1.2	1.4	2.9	-1.1	1.1	1.1	-0.5	1.2	1.7
Cocaine response after cond. corrected	0.4	0.5	0.8	0.8	-0.9	-0.9	0.7	-0.4	0.3
Cocaine response after cond. not corrected	1.2	1.3	1.9	0.9	-1.4	-1.4	1.3	-1.0	-0.4
Cocaine response before conditioning	0.6	0.7	1.3	0.3	-0.7	-0.7	1.0	-1.1	-1.1
Saline control response	2.2	2.9	3.7	-1.9	1.9	1.9	-1.6	1.4	1.3
Bone: connectivity density	1.7	2.7	8.8	-1.0	1.2	1.2	3.0	0.9	-1.7
Bone: cortical apparent density	3.3	4.4	8.2	2.9	-2.3	-2.3	-0.9	-2.3	-1.0
Bone: cortical area	1.4	2.1	5.3	-0.7	1.0	1.0	2.3	0.3	-2.2
Bone: cortical porosity	3.6	3.9	8.6	-2.9	2.1	2.1	1.7	1.2	-1.3
Bone: cortical porosity	2.2	2.4	3.9	-2.0	1.5	1.5	1.9	0.7	-1.5
Bone: cortical thickness	5.9	9.7	14.6	3.5	-2.9	-2.9	0.8	-3.7	-3.8
Bone: cortical thickness	4.9	5.7	10.3	2.4	-2.4	-2.4	-0.1	-3.2	-2.6
Bone: cortical tissue density	3.2	4.2	7.8	2.8	-2.3	-2.3	-1.0	-2.3	-0.9
Condit. Reinf. active minus inactive responses	2.1	2.3	4.4	-2.1	1.9	1.9	0.4	1.4	0.5
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.9	-1.4	1.1	1.1	0.1	0.8	0.2
Condit. Reinf. active responses	2.9	3.5	5.7	-2.4	2.3	2.3	0.6	1.9	0.8
Condit. Reinf. inactive responses	1.1	1.3	1.8	-1.0	1.3	1.3	1.1	1.4	0.4
Incentive salience index mean	1.6	1.9	3.7	-1.9	1.7	1.7	1.1	1.1	-0.3
Condit. Reinf. lever presses	0.3	0.4	0.6	-0.8	0.5	0.5	0.7	0.1	-0.7
Condit. Reinf. active minus inactive responses	4.0	5.0	8.5	-2.7	2.3	2.3	2.9	1.9	-0.5
Condit. Reinf. active-inactive response ratio	2.3	2.4	4.1	-1.9	1.6	1.6	2.0	1.2	-0.7
Condit. Reinf. active responses	4.8	6.6	10.5	-3.2	3.0	3.0	2.1	2.5	0.6
Condit. Reinf. inactive responses	2.3	2.8	4.1	-2.0	2.0	2.0	-0.0	1.6	1.4
Condit. Reinf. lever presses	1.1	1.5	3.2	-1.8	1.5	1.5	0.7	0.8	-0.5
Condit. Reinf. lever reinforcers received	3.9	5.5	8.7	-2.9	2.7	2.7	2.0	2.3	0.5
Conditioned reinforcement - actives	0.6	0.6	1.2	-0.8	1.1	1.0	0.3	0.9	-0.2
Conditioned reinforcement - inactives	1.0	1.1	1.8	-0.9	1.2	1.2	0.6	0.8	-1.4
Conditioned locomotion	2.0	2.4	3.7	-1.4	1.8	1.9	1.3	1.6	-1.0
Patch foraging indifference point 0 sec	3.6	5.8	9.3	-2.6	3.1	3.0	1.8	2.6	0.0
Patch foraging indifference point AUC	1.0	1.1	1.9	-1.1	1.3	1.2	0.6	1.4	0.4
Delay disc. indifference point, 0s delay	0.6	0.6	1.3	1.0	-0.8	-0.8	0.3	-0.2	1.1
Delay disc. indifference point, 16s delay	0.4	0.4	0.7	-0.2	0.7	0.7	0.8	0.7	0.6
Delay disc. indifference point, 2s delay	1.7	1.9	9.2	-0.1	0.7	0.7	3.0	1.1	-0.4
Delay disc. indifference point, 24s delay	1.7	1.7	2.3	-1.0	1.5	1.5	1.5	1.5	-0.2
Delay disc. indifference point, 4s delay	0.6	0.7	1.1	1.0	-0.8	-0.8	0.8	-0.9	-0.4
Delay disc. indifference point, 8s delay	0.2	0.2	0.7	0.6	-0.2	-0.2	0.8	-0.1	-0.5
Indifference point function ln k	0.4	0.6	1.1	0.8	-0.9	-0.8	0.4	-1.1	-0.7
Indifference point function log k	0.4	0.6	1.1	0.8	-0.9	-0.8	0.4	-1.1	-0.7
Patch foraging total patch changes 0 sec	3.8	6.2	9.8	-2.6	3.1	3.1	1.9	2.7	0.1
Patch foraging total patch changes 12 sec	5.4	7.0	11.1	-3.0	3.1	3.0	1.3	3.3	1.5
Patch foraging total patch changes 18 sec	2.5	3.2	4.9	-2.2	2.2	2.1	0.2	1.9	1.0
Patch foraging total patch changes 24 sec	3.4	4.1	5.7	-2.1	2.4	2.4	2.2	2.1	-0.1
Patch foraging total patch changes 6 sec	1.8	2.7	4.3	-1.8	2.1	2.0	1.4	1.8	-0.3
Patch foraging time to switch 0 sec	0.2	0.4	1.2	0.2	-0.5	-0.5	-1.1	-0.6	0.2
Patch foraging water rate 0 sec	1.2	1.9	2.6	-1.1	1.6	1.5	1.5	1.2	-1.3
Patch foraging water rate 12 sec	1.8	2.7	4.3	1.7	-1.5	-1.5	1.1	-1.8	-2.1
Patch foraging water rate 18 sec	1.4	1.8	4.8	0.6	-0.6	-0.6	2.2	-0.9	-2.1
Patch foraging water rate 24 sec	0.3	0.5	1.8	0.3	-0.5	-0.4	1.3	-0.3	-0.7
Patch foraging water rate 6 sec	0.8	1.2	3.3	0.8	-0.6	-0.5	1.5	-0.8	-1.8
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.6	-0.6	0.5	0.5	-0.8	0.2	0.0
Distance traveled before self-admin	0.7	0.7	1.5	0.7	-1.2	-1.1	-0.0	-0.6	0.8
Distance traveled after self-admin	0.4	0.4	1.9	-0.2	-0.5	-0.4	-0.4	-0.3	1.4
Extensor digitorum longus weight	1.3	5.2	22.9	1.7	-0.9	-0.9	-4.8	-0.2	2.0
Bone: elastic displacement	3.3	3.7	6.5	1.9	-1.9	-1.9	0.7	-2.2	-2.6
Bone: elastic work	1.9	2.5	10.7	0.7	-0.6	-0.6	1.3	-1.1	-3.3
Bone: endosteal estimation	10.6	23.1	38.4	-6.2	5.6	5.6	2.6	5.3	1.3
Bone: endosteal perimeter	11.9	24.6	36.9	-6.1	5.8	5.8	3.3	5.7	1.1
Epididymis fat weight	0.7	1.7	3.1	-1.1	1.8	1.7	-0.2	1.7	-0.3
Delta time in closed arm before/after self-admin	0.6	0.6	1.7	0.1	-0.4	-0.4	1.3	-0.3	-1.2
Delta time in open arm before/after self-admin	1.3	1.2	3.8	0.4	-0.1	-0.1	-1.8	0.2	2.0
Diff in mean of infusions in LGA sessions	0.7	0.8	1.4	0.9	-1.0	-0.8	-1.2	-1.1	-0.2
Delay discount exponential model param	0.6	0.6	2.1	0.1	-0.6	-0.6	-1.5	-0.7	0.3
Extinction: sum of active levers before priming	1.2	1.2	3.9	-0.6	0.8	0.8	-0.8	1.0	2.0
Active lever presses in extinction session 6	1.6	1.6	2.8	-1.7	1.5	1.6	-0.4	1.2	0.7
Bone: final force	1.3	2.1	7.7	-0.2	0.3	0.3	2.8	0.0	-2.1
Bone: final moment	1.4	2.3	8.1	-0.2	0.3	0.3	2.8	-0.1	-2.4
Food consumed during 24 hour testing period	2.4	2.8	4.4	-2.1	2.0	2.0	0.3	2.0	-0.2
Glucose	0.7	1.1	1.7	1.0	-1.3	-1.3	-0.7	-1.0	0.7
Heart weight	0.0	0.0	0.1	0.2	-0.1	-0.1	0.1	0.1	0.3
Delay discount hyperbolic model param	0.5	0.6	2.4	-0.1	-0.5	-0.5	-1.6	-0.6	0.3
Intermittent access intake day 1-15 change	0.6	0.6	1.1	-0.7	0.4	0.5	-1.1	0.6	1.0
Intermittent access intake escalation	0.2	0.2	0.8	-0.3	0.1	0.1	-0.9	0.2	0.5
Intermittent access intake escalation 2	0.5	0.5	0.7	-0.9	0.7	0.7	-0.5	0.8	0.4
Intermitt. access day 1 inactive lever presses	3.3	3.6	5.6	-2.3	2.4	2.4	1.5	1.6	-0.3
Intermitt. access day 15 inactive lever presses	1.6	1.8	3.2	-1.7	1.8	1.8	-0.6	0.9	-0.1
Intermitt. access escalation Index	2.3	2.0	3.9	1.6	-2.0	-1.8	-0.0	-1.3	0.8
Intermittent access day 1 total infusions	0.7	0.8	1.3	-0.6	0.9	0.9	1.2	0.8	-1.1
Intermittent access day 15 total infusions	0.4	0.5	0.8	-0.6	0.8	0.9	0.1	0.9	-0.4
Intermittent access terminal intake (last 3 days)	1.8	2.0	3.2	-1.5	1.7	1.8	0.5	1.8	-0.2
Intermittent access total infusions	2.2	2.5	3.6	-1.6	1.9	1.9	1.2	1.7	-1.0
Intermittent access day 1 locomotion	3.4	3.5	4.8	-1.5	2.0	2.0	1.9	1.6	-2.2
Intermittent access day 15 total locomotion	4.5	4.9	6.0	-2.3	2.4	2.4	1.9	2.1	-2.0
Intermittent access total locomotion	6.4	7.3	9.7	-2.7	3.1	3.1	2.2	2.4	-2.6
Intermittent access standard deviation	1.2	1.2	2.1	-1.1	1.3	1.4	0.1	0.8	-1.4
Left kidney weight	1.0	2.7	4.2	1.6	-1.4	-1.5	1.5	-1.8	-2.1
Right kidney weight	1.2	3.3	7.8	1.1	-1.1	-1.1	2.5	-1.4	-2.8
Cocaine induced anxiety	0.6	0.7	2.1	0.8	-0.6	-0.5	0.3	-1.0	-1.4
Post-drug Anxiety	0.7	0.7	1.0	1.0	-0.9	-0.8	0.1	-0.9	-1.0
Baseline Anxiety	0.7	0.7	1.3	1.1	-1.1	-1.1	0.0	-0.8	-0.3
Tail length	1.8	5.5	7.3	-2.5	2.7	2.7	2.3	2.6	-0.6
Length with tail	1.8	6.7	14.5	-2.4	2.4	2.4	3.8	2.6	-1.1
Length without tail	0.5	1.2	5.2	-0.6	0.4	0.4	2.3	0.7	-0.9
Times rat made contact with spout	0.6	0.7	0.9	-0.9	0.9	0.9	0.8	0.7	-0.8
Lifetime Intake	2.4	2.7	4.2	-1.8	2.0	2.1	1.0	1.6	-0.8
Liver weight, left	0.9	1.5	5.1	-1.0	0.8	0.8	2.3	1.1	-0.1
Liver weight, right	1.6	2.7	6.8	1.5	-1.1	-1.1	2.6	-0.9	-2.0
Locomotor activity	0.5	0.8	1.8	-1.1	0.6	0.7	0.9	-0.0	-1.3
Locomotor testing distance	1.1	1.8	4.3	-2.1	1.7	1.7	-0.1	0.7	-0.4
Locomotor testing rearing	1.3	2.0	4.9	-2.2	1.5	1.6	-1.5	0.6	0.1
Locomotion in novel chamber	0.8	1.0	4.1	0.1	-0.3	-0.3	2.0	-0.3	-1.4
Locomotion in novel chamber post-restriction	1.7	2.0	3.9	-0.8	1.4	1.4	2.0	1.9	0.3
Fecal boli incidents, locomotor time 1	1.0	1.0	5.5	-0.2	0.1	0.2	-0.6	0.6	2.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.5	-0.1	-0.2	-0.4	-0.2	-0.3
Time >=10cm from walls, locomotor time 1	2.0	2.0	3.6	1.4	-1.8	-1.9	-0.7	-1.6	0.2
Bouts of movement, locomotor time 1	0.5	0.5	1.3	0.8	-0.3	-0.3	-1.1	-0.6	-0.7
Total resting periods, locomotor time 1	0.5	0.5	0.9	1.0	-0.4	-0.3	-0.9	-0.7	-0.7
Rest time, locomotor task time 1	0.5	0.5	2.2	0.4	-0.4	-0.4	-0.7	-0.2	1.5
Distance moved, locomotor task time 1	1.4	1.5	5.7	-0.7	0.9	0.9	1.0	0.5	-2.4
Vertical activity count, locomotor time 1	1.0	1.1	4.3	-0.5	0.5	0.5	1.2	0.1	-2.1
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.9	0.2	-0.7	-0.5	-0.4	-0.9	-0.8
Bouts of movement, locomotor time 2	1.1	1.2	5.0	0.6	-0.1	0.0	-2.2	-0.4	1.2
Total resting periods, locomotor time 2	1.3	1.4	5.5	0.9	-0.4	-0.3	-2.3	-0.6	1.3
Rest time, locomotor task time 2	3.6	4.1	7.3	2.3	-1.8	-2.0	-1.9	-1.2	2.7
Distance moved, locomotor task time 2	1.8	2.1	10.2	-0.9	0.5	0.6	0.9	-0.1	-3.2
Vertical activity count, locomotor time 2	2.2	2.4	4.4	-2.1	1.5	1.6	0.6	0.8	-2.0
Light reinforcement 1	0.2	0.4	0.6	-0.4	0.8	0.8	-0.3	0.7	0.6
Light reinforcement 2	0.3	0.4	0.6	-0.4	0.7	0.7	0.3	0.7	0.5
Bone: marrow area	10.3	22.2	37.3	-6.1	5.5	5.5	2.6	5.2	1.2
Bone: maximum diameter	3.1	5.7	8.9	-2.6	2.6	2.6	3.0	2.4	-0.2
Bone: maximum force	1.5	2.6	8.3	-0.9	1.2	1.2	2.9	1.0	-1.6
Bone: maximum moment	1.6	2.8	8.5	-0.8	1.2	1.2	2.9	0.8	-1.9
Mean time between licks in bursts	0.1	0.2	0.5	0.1	0.4	0.4	0.3	0.7	0.5
Mean num. licks in bursts	0.3	0.4	0.7	-0.5	0.8	0.8	-0.5	0.6	-0.5
Cd content in liver	1.5	1.7	2.3	1.5	-1.5	-1.5	-1.4	-1.1	0.5
Co content in liver	0.4	0.5	2.0	0.1	-0.4	-0.4	-1.4	-0.4	0.5
Cu content in liver	0.3	0.3	0.4	-0.5	0.6	0.6	-0.4	0.6	0.6
Fe content in liver	0.2	0.2	0.6	0.1	-0.1	-0.1	-0.7	-0.4	0.8
K content in liver	1.2	1.2	2.7	-1.0	0.8	0.8	1.6	1.2	0.9
Mg content in liver	0.4	0.5	1.8	-0.3	0.3	0.3	0.2	0.8	1.3
Mn content in liver	0.7	0.8	4.7	0.1	-0.2	-0.2	2.2	0.0	-0.0
Na content in liver	0.5	0.6	1.4	-0.8	0.6	0.6	0.4	0.6	1.2
Rb content in liver	1.6	2.0	3.5	1.5	-1.9	-1.9	-0.2	-1.4	0.9
Se content in liver	0.6	0.7	1.2	0.9	-1.0	-1.0	-0.1	-0.5	1.1
Sr content in liver	0.6	0.6	2.1	-0.1	0.1	0.1	1.2	-0.1	-1.4
Zn content in liver	0.6	0.7	3.8	0.2	-0.3	-0.3	2.0	0.1	-0.2
Bone: minimum diameter	8.8	16.4	23.3	-4.7	4.8	4.8	3.2	4.4	-0.4
Time in familiar zone, hab. session 1	2.2	2.1	4.1	-1.3	1.3	1.3	-0.5	1.7	2.0
Time in novel zone, hab. session 1	2.3	2.2	3.9	1.5	-1.5	-1.5	-0.2	-2.0	-1.7
Total zone transitions, hab. session 1	0.5	0.7	2.4	-0.2	0.3	0.3	1.2	0.1	-1.5
Total locomotion distance, hab. session 1	1.8	2.5	9.3	-0.5	0.6	0.6	2.2	-0.0	-3.1
Locomotion velocity, hab. session 1	1.8	2.6	7.4	-0.8	0.9	0.9	2.4	0.4	-2.7
Time in familiar zone, hab. session 2	1.9	2.0	3.2	-1.8	1.5	1.5	-0.5	1.5	1.3
Time in novel zone, hab. session 2	2.2	2.2	3.7	1.9	-1.5	-1.5	0.8	-1.5	-1.4
Total zone transitions, hab. session 2	0.1	0.2	0.4	-0.3	0.3	0.3	0.5	0.2	-0.6
Total locomotion distance, hab. session 2	0.6	0.8	1.3	-0.5	0.9	0.9	1.1	0.7	-1.1
Locomotion velocity, hab. session 2	0.7	0.9	1.9	-0.4	0.8	0.8	1.4	0.7	-1.2
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.2	0.4	0.4	0.3	0.2	-0.5
Novelty place preference	0.1	0.1	0.3	-0.1	0.1	0.1	0.2	-0.0	-0.6
Time in novel zone, NPP test	0.1	0.1	0.5	0.0	-0.0	-0.0	0.2	-0.3	-0.7
Total zone transitions, NPP test	0.6	0.9	3.1	0.1	0.1	0.1	1.7	-0.0	-1.4
Total locomotion distance, NPP test	1.3	1.8	5.1	-0.5	0.7	0.7	2.1	0.3	-2.2
Locomotion velocity, NPP test	0.8	1.2	2.7	-0.3	0.8	0.8	1.5	0.6	-1.6
Intraocular pressure	0.8	1.1	1.5	-0.7	1.2	1.2	-1.2	1.0	0.9
Delta distance traveled before/after self-admin	0.2	0.2	0.6	0.0	-0.2	-0.1	-0.8	-0.7	0.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.4	0.4	0.4	0.1	0.0	0.1
Parametrial fat weight	1.2	2.3	7.5	-0.5	0.8	0.8	2.7	1.1	-1.9
Pavlov. Cond. lever latency	1.6	2.0	3.8	1.4	-1.2	-1.2	-1.8	-0.3	2.0
Pavlov. Cond. magazine entry latency	2.4	3.1	4.9	-2.2	2.0	2.0	1.7	1.3	-0.9
Pavlov. Cond. change in total contacts	1.7	1.8	3.3	-1.8	1.6	1.6	0.7	0.7	-1.1
Pavlov. Cond. index score	2.0	2.5	3.8	-2.0	1.8	1.8	1.6	1.0	-1.2
Pavlov. Cond. latency score	1.7	2.1	3.2	-1.8	1.6	1.6	1.5	0.8	-1.3
Pavlov. Cond. lever contacts	1.1	1.3	2.2	-1.4	1.1	1.1	1.0	0.4	-1.5
Pavlov. Cond. magazine entry number	1.7	2.1	3.1	1.8	-1.7	-1.7	-1.4	-1.0	0.9
Pavlov. Cond. intertrial magazine entries	2.0	2.4	3.7	-1.2	1.7	1.7	-0.3	1.9	1.9
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	3.1	-1.8	1.6	1.6	1.5	0.8	-1.2
Pavlov. Cond. response bias	2.2	2.6	3.8	-1.9	1.7	1.7	2.0	0.8	-1.6
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.7	-0.5	-0.5	-0.8	-0.4	-0.0
Pavlov. Cond. magazine entry latency	1.8	2.1	3.6	1.6	-1.9	-1.9	-0.4	-1.5	0.5
Pavlov. Cond. change in total contacts	0.5	0.7	1.3	-1.1	0.8	0.8	0.4	0.8	0.8
Pavlov. Cond. index score	0.1	0.1	0.2	-0.1	-0.3	-0.3	0.4	-0.3	0.3
Pavlov. Cond. latency score	0.1	0.2	0.3	0.0	-0.5	-0.5	0.4	-0.5	0.2
Pavlov. Cond. lever contacts	0.2	0.3	0.4	-0.6	0.5	0.5	0.7	0.3	-0.2
Pavlov. Cond. magazine entry number	2.3	2.8	5.0	-1.8	2.2	2.2	0.3	1.9	-0.0
Pavlov. Cond. intertrial magazine entries	10.1	13.2	20.7	-4.1	4.5	4.5	1.5	4.3	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.0	-0.4	-0.4	0.5	-0.4	0.3
Pavlov. Cond. response bias	0.1	0.1	0.5	-0.1	-0.0	-0.0	0.7	-0.0	0.0
Time in closed arm before self-admin	1.7	1.9	3.5	1.0	-1.4	-1.3	-0.1	-1.9	-1.8
Time in closed arm after self-admin	1.8	1.8	3.4	0.8	-1.5	-1.4	1.0	-1.4	-1.8
Time in open arm before self-admin	0.4	0.4	0.7	0.8	-0.6	-0.8	0.1	-0.7	-0.4
Time in open arm after self-admin	1.3	1.4	3.8	-0.2	0.9	0.7	-1.5	1.0	1.9
Bone: periosteal estimation	6.0	12.5	17.8	-4.2	4.1	4.1	3.3	3.5	-0.7
Bone: periosteal perimeter	3.2	5.3	10.0	-2.4	2.3	2.3	3.2	2.0	-1.3
Bone: post-yield work	1.4	2.0	2.9	-1.7	1.6	1.6	1.2	1.6	-0.0
Progressive ratio test 1 active lever presses	3.6	3.8	5.4	-2.2	2.2	2.3	1.7	1.9	-0.8
Progressive ratio test 1 breakpoint	4.4	4.6	7.4	-2.6	2.6	2.7	1.3	2.3	-0.3
Progressive ratio test 1 inactive lever presses	3.6	3.9	6.2	-2.4	2.5	2.5	1.2	2.0	0.2
Progressive ratio test 2 active lever presses	4.3	4.6	6.7	-2.2	2.6	2.6	1.9	2.3	-0.7
Progressive ratio test 2 breakpoint	4.6	5.1	7.4	-2.4	2.7	2.7	1.8	2.5	-0.6
Progressive ratio test 2 inactive lever presses	3.7	4.3	6.7	-2.1	2.6	2.6	1.5	2.3	-0.7
Incentive Sensitization - Responses	3.1	3.1	4.4	-1.9	2.1	2.1	1.5	2.1	0.2
Incentive Sensitization - Breakpoint	2.8	2.9	4.0	-1.8	2.0	2.0	1.6	2.0	0.2
Sum of active levers in priming session hrs 5-6	1.2	1.2	5.2	0.1	-0.2	-0.1	-1.4	0.0	2.3
Progressive ratio	0.1	0.2	0.4	0.5	-0.0	-0.0	0.6	0.4	0.5
Food seeking constrained by brief footshock	2.7	3.3	6.0	-2.4	2.0	2.1	0.2	2.2	0.8
Seeking ratio, punishment vs. effort	0.9	1.1	3.1	-1.8	1.1	1.2	-0.3	0.9	0.1
Retroperitoneal fat weight	1.2	4.0	4.2	-2.0	2.0	2.1	1.9	2.0	-2.0
Reaction time number correct	0.8	1.2	1.9	1.4	-1.2	-1.1	1.3	-0.7	-0.4
Reaction time mean minus median	0.2	0.3	0.8	0.6	-0.3	-0.3	-0.9	-0.4	0.4
Reaction time mean minus median AUC	0.7	0.9	1.9	1.4	-1.1	-1.1	-0.2	-1.0	0.2
Reaction time num false alarms	2.0	2.7	4.4	-2.1	1.8	1.8	1.5	1.7	0.0
Reaction time num false alarms AUC	2.3	3.2	4.6	-2.1	1.9	2.0	1.9	1.9	-0.2
Reaction time trials correct on left	0.8	1.2	1.9	1.4	-1.2	-1.1	1.3	-0.7	-0.4
Reaction time trials on left	0.8	1.2	1.9	1.4	-1.2	-1.1	1.4	-0.7	-0.4
Reaction time mean	0.5	0.7	1.0	1.0	-0.8	-0.9	-0.7	-1.0	0.6
Reaction time mean AUC	0.8	1.1	1.4	1.0	-1.0	-1.1	-1.2	-1.2	0.8
Median of all reaction times	0.6	0.8	1.1	0.9	-0.9	-1.0	-0.7	-1.0	0.7
Reaction time omissions	0.0	0.1	0.1	0.4	0.0	0.1	0.3	0.0	0.3
Reaction time false alarm rate	2.3	3.2	6.2	-2.5	2.1	2.1	0.7	1.8	0.0
Reaction time premature initiation rate	0.4	0.6	1.3	-0.8	1.1	1.1	0.0	0.7	-0.1
Reaction time premature initiations	0.2	0.3	0.8	-0.1	0.4	0.5	0.9	0.4	-0.2
Std. dev. reaction times	0.2	0.3	0.6	0.8	-0.5	-0.5	-0.7	-0.5	0.4
Reaction time trials completed	0.8	1.2	1.9	1.4	-1.2	-1.1	1.4	-0.7	-0.4
Reaction time trials AUC	0.8	1.2	1.9	1.4	-1.2	-1.1	1.3	-0.7	-0.4
Run reversals in cocaine runway, females	0.9	0.9	2.4	0.9	-0.6	-0.6	-0.8	-0.9	-1.6
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.5	-0.4	-0.4	-0.1	-0.3	0.1
Latency to leave start box in cocaine runway	0.3	0.4	0.7	0.6	-0.7	-0.7	-0.4	-0.8	0.2
Latency to leave start box in cocaine runway, F	0.9	1.0	2.0	1.1	-1.1	-1.1	-0.3	-1.4	-0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.6	-0.3	0.0	0.0	-0.2	0.3	0.7
Std. dev. time between licks in bursts	0.1	0.2	0.7	0.2	0.3	0.3	-0.8	0.2	0.3
Total sessions with >9 infusions	0.4	0.4	1.0	-0.2	0.5	0.6	0.9	0.2	-1.0
Short access day 1 total inactive lever presses	1.1	1.2	3.8	-0.7	0.8	0.8	1.4	0.2	-1.9
Short access day 10 total inactive lever presses	0.9	1.0	1.4	-0.8	1.1	1.0	-0.8	1.0	1.2
Short access day 1 total infusions	0.7	0.7	1.5	-0.9	1.2	1.2	0.4	0.7	-0.3
Short access day 10 total infusions	3.9	4.3	7.1	-2.5	2.6	2.7	0.7	2.2	-0.4
Short access total infusions	2.0	2.2	4.0	-2.0	1.9	2.0	0.4	1.3	-0.3
Short access day 1 locomotion	2.4	2.6	4.9	-1.5	2.2	2.2	0.8	1.6	-0.7
Short access day 10 total locomotion	8.0	9.0	14.4	-3.4	3.8	3.7	1.4	3.1	-1.7
Short access total locomotion	3.9	4.0	6.6	-2.2	2.6	2.5	0.6	1.8	-1.6
One hour access (0.3 mA shock)	0.9	1.0	1.6	-1.3	1.2	1.1	-0.0	1.1	0.8
Compulsive drug intake	1.5	1.6	2.3	1.1	-1.5	-1.5	1.0	-1.4	-0.8
One hour access (shock baseline)	1.6	1.8	3.0	-1.5	1.7	1.7	-0.3	1.6	0.5
Social response proportion	0.1	0.2	0.3	0.5	-0.5	-0.5	-0.3	-0.2	0.3
Social responses	0.0	0.0	0.1	-0.4	0.1	0.2	0.2	-0.0	-0.2
Social time	0.2	0.3	1.2	-0.4	0.1	0.1	-0.6	0.3	1.1
Soleus weight	0.1	0.2	0.4	-0.5	0.4	0.4	0.4	0.0	-0.6
Bone: stiffness	1.0	1.5	4.8	-1.0	0.9	0.9	2.2	1.2	0.2
Tibialis anterior weight	0.5	1.6	4.9	-0.7	1.2	1.2	-2.2	1.1	0.4
Time to tail flick, vehicle, before self-admin	0.7	0.7	2.5	0.7	-0.8	-0.8	1.6	-0.3	0.0
Time to tail flick, vehicle, after self-admin	1.0	1.1	2.1	-0.4	0.8	0.7	1.0	1.5	1.4
Time to tail flick, test, before self-admin	0.5	0.5	1.2	0.5	-0.8	-0.9	-1.1	-0.5	0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.5	-0.2	-0.4	-0.0	-0.3	0.1
Delta time to tail flick, vehicle, before/after SA	2.0	2.0	3.2	-1.4	1.8	1.7	-0.0	1.8	0.9
Delta time to tail flick, test, before/after SA	0.1	0.1	0.4	0.2	0.1	0.0	0.6	0.2	0.4
Tibia length	1.1	3.1	9.9	0.9	-0.7	-0.7	3.1	-0.7	-2.6
Ambulatory time before self-admin	0.3	0.3	0.7	0.4	-0.8	-0.8	0.4	-0.4	0.4
Ambulatory time after self-admin	0.1	0.1	0.5	-0.4	-0.1	-0.0	0.0	-0.1	0.7
Bone: tissue strength	1.2	1.1	1.6	1.3	-1.2	-1.2	1.1	-0.9	-0.3
Total heroin consumption	0.3	0.3	0.8	-0.9	0.3	0.4	0.7	0.2	0.5
Bone: trabecular number	2.0	3.1	10.8	-1.0	1.2	1.2	3.3	1.0	-1.5
Bone: trabecular spacing	0.9	1.2	4.6	0.2	-0.4	-0.4	-2.1	-0.1	1.4
Bone: trabecular thickness	2.1	2.5	6.8	-0.7	1.3	1.3	2.6	0.9	-1.9
Bone: trabecular tissue density	1.4	1.9	3.9	2.0	-1.3	-1.3	1.5	-1.1	-1.1
Water consumed over 24 hours	0.4	0.5	2.5	-0.0	0.1	0.1	0.7	-0.1	-1.6
Number of responses in last shaping day	0.4	0.4	0.7	-0.8	0.8	0.8	0.1	0.3	-0.8