Hub : Genes

Proca1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Proca1	0.05	0.04	4.1e-05	0.02	0.04	0.03	0.03	1.1e-03	7.4e-05	3.4e-04	4.9e-04
2	PL	gene expression	Proca1	0.08	0.06	5.9e-10	0.07	0.09	0.08	0.08	2.3e-08	1.6e-09	3.5e-09	6.5e-09
3	IC	gene expression	Proca1	0.11	0.1	4.2e-04	0.04	0.07	0.04	0.05	1.2e-02	1.0e-03	8.6e-03	4.5e-03
4	BLA	gene expression	Proca1	0.06	0.06	2.3e-03	0.04	0.04	0.04	0.03	4.1e-03	3.5e-03	5.3e-03	9.9e-03
5	Brain	gene expression	Proca1	0.11	0.08	5.3e-11	0.09	0.11	0.11	0.11	5.4e-09	2.3e-10	3.4e-10	1.4e-10
6	NAcc	gene expression	Proca1	0.24	0.14	0.0e+00	0.2	0.21	0.21	0.21	5.7e-30	3.8e-31	3.3e-31	3.4e-31
7	RMTg	intron excision ratio	chr10_63599583_63600030	0.12	0.1	2.9e-03	0.06	0.07	0.09	0.06	1.1e-02	4.9e-03	2.5e-03	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	2.0	3.6	4.1	-2.0	-2.0	-2.0	-2.0	-2.0	2.0	1.3
Area under the delay curve	1.6	2.4	3.2	1.5	1.5	1.6	1.6	1.8	-1.8	-0.8
BMI with tail	1.7	5.8	6.2	-2.5	-2.5	-2.5	-2.5	-2.4	2.4	2.0
BMI without tail	1.2	6.3	6.8	-2.6	-2.6	-2.6	-2.6	-2.6	2.6	2.0
Body weight	2.7	11.6	11.9	-3.4	-3.5	-3.4	-3.4	-3.3	3.4	3.4
Weight adjusted by age	0.1	0.2	0.3	-0.4	-0.4	-0.4	-0.4	-0.5	0.6	-0.5
Bone surface	1.4	2.7	3.1	-1.7	-1.7	-1.7	-1.7	-1.8	1.7	0.9
Bone volume	1.2	2.4	2.6	-1.6	-1.6	-1.6	-1.6	-1.6	1.6	1.1
Breakpoint value in progressive ratio session	0.4	0.7	1.0	-0.8	-0.8	-0.9	-0.9	-1.0	1.0	-0.4
Number of licking bursts	0.1	0.4	0.4	0.6	0.6	0.6	0.6	0.6	-0.6	-0.6
Context. condit. distance diff. score	0.6	0.7	0.7	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	0.7
Locomotion velocity, session 1	2.1	2.4	2.4	-1.6	-1.6	-1.5	-1.5	-1.5	1.5	1.5
Locomotion distance, session 1	0.3	0.4	1.0	-0.6	-0.6	-0.5	-0.5	-0.5	0.6	1.0
Locomotion velocity, session 2	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	-0.2	0.3	0.1
Locomotion distance, session 2	1.1	1.5	1.7	-1.3	-1.3	-1.3	-1.3	-1.3	1.3	0.8
Locomotion velocity, session 3	3.6	4.1	6.3	2.0	2.0	2.0	1.9	1.9	-1.9	-2.5
Locomotion distance, session 3	0.4	0.5	0.5	0.7	0.7	0.7	0.7	0.7	-0.7	-0.6
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	-0.1	-0.1	-0.1	-0.1	-0.2	0.2	-0.5
Stereotopy head waving duration, day 3	0.6	0.7	2.4	0.7	0.7	0.7	0.7	0.5	-0.5	-1.6
Locomotion velocity, session 7	0.3	0.4	0.6	-0.6	-0.6	-0.6	-0.6	-0.7	0.8	-0.4
Locomotion distance, session 7	0.5	0.6	0.8	-0.8	-0.8	-0.8	-0.8	-0.9	0.9	0.4
Stereotopy head waving bouts, day 7	0.4	0.5	0.6	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	0.0
Stereotopy head waving duration, day 7	0.2	0.3	0.4	-0.5	-0.5	-0.5	-0.6	-0.6	0.6	-0.3
Locomotion velocity, session 8	0.0	0.0	0.0	-0.2	-0.2	-0.1	-0.1	-0.1	0.1	0.1
Locomotion distance, session 8	0.7	1.1	1.2	-1.1	-1.1	-1.1	-1.1	-1.1	1.1	0.7
Degree of sensitization distance	3.1	3.4	3.7	-1.9	-1.9	-1.9	-1.9	-1.9	1.9	1.5
Degree of sensitization stereotypy	0.5	0.6	0.7	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	0.3
Conditioned locomotion	1.7	2.0	3.5	1.4	1.4	1.3	1.3	1.3	-1.3	-1.9
Cocaine response after cond. corrected	1.2	1.7	1.9	-1.4	-1.4	-1.4	-1.4	-1.4	1.3	1.0
Cocaine response after cond. not corrected	1.6	2.3	2.6	-1.6	-1.6	-1.6	-1.6	-1.6	1.4	1.0
Cocaine response before conditioning	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.5	-0.5	0.5	0.2
Saline control response	0.0	0.0	0.1	0.0	0.0	0.0	0.0	-0.0	0.0	-0.3
Bone: connectivity density	3.6	5.7	6.5	-2.5	-2.5	-2.5	-2.5	-2.6	2.5	1.5
Bone: cortical apparent density	0.3	0.5	0.6	0.8	0.8	0.8	0.7	0.7	-0.7	-0.5
Bone: cortical area	1.3	2.1	2.4	1.5	1.5	1.5	1.5	1.6	-1.5	-1.0
Bone: cortical porosity	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.6	-0.6	0.6	0.4
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	-0.4	0.4	0.2
Bone: cortical thickness	2.7	4.4	4.7	2.2	2.2	2.1	2.1	2.2	-2.1	-1.9
Bone: cortical thickness	0.0	0.0	0.1	0.2	0.2	0.1	0.1	0.1	-0.1	-0.3
Bone: cortical tissue density	0.2	0.3	0.3	0.6	0.6	0.6	0.5	0.5	-0.5	-0.4
Condit. Reinf. active minus inactive responses	0.8	0.9	1.8	0.9	0.9	0.9	0.9	0.8	-0.8	-1.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	0.4	0.4	0.4	0.4	0.4	-0.4	-0.8
Condit. Reinf. active responses	0.0	0.1	0.3	0.1	0.1	0.1	0.1	0.1	-0.1	-0.5
Condit. Reinf. inactive responses	0.3	0.4	0.4	-0.6	-0.6	-0.6	-0.6	-0.6	0.6	0.5
Incentive salience index mean	0.4	0.5	1.5	0.6	0.6	0.6	0.6	0.6	-0.5	-1.2
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	-0.3	0.3	-0.5
Condit. Reinf. active minus inactive responses	0.3	0.5	1.5	0.6	0.6	0.6	0.6	0.5	-0.4	-1.2
Condit. Reinf. active-inactive response ratio	0.4	0.6	0.9	0.8	0.8	0.8	0.8	0.7	-0.7	-0.9
Condit. Reinf. active responses	0.2	0.3	1.4	0.5	0.5	0.4	0.4	0.3	-0.2	-1.2
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.2	-0.2	-0.2	-0.2	-0.3	0.3	-0.5
Condit. Reinf. lever presses	2.3	3.4	3.5	1.9	1.9	1.9	1.9	1.8	-1.7	-1.8
Condit. Reinf. lever reinforcers received	0.5	0.6	1.7	0.7	0.8	0.7	0.7	0.6	-0.6	-1.3
Conditioned reinforcement - actives	0.1	0.3	0.4	-0.6	-0.6	-0.6	-0.6	-0.6	0.5	0.5
Conditioned reinforcement - inactives	0.1	0.3	1.3	-0.4	-0.4	-0.4	-0.4	-0.3	0.1	1.1
Conditioned locomotion	0.1	0.2	0.3	-0.6	-0.6	-0.5	-0.5	-0.4	0.2	0.3
Patch foraging indifference point 0 sec	0.3	0.7	1.3	0.8	0.8	0.8	0.8	0.8	-0.7	-1.1
Patch foraging indifference point AUC	1.4	3.3	4.0	1.8	1.8	1.8	1.8	1.8	-1.8	-2.0
Delay disc. indifference point, 0s delay	0.8	0.9	1.3	1.0	1.0	1.0	1.0	1.1	-1.1	-0.4
Delay disc. indifference point, 16s delay	1.1	1.6	2.4	1.3	1.2	1.3	1.3	1.6	-1.5	-0.0
Delay disc. indifference point, 2s delay	2.7	3.0	3.4	1.8	1.7	1.8	1.8	1.8	-1.8	-1.3
Delay disc. indifference point, 24s delay	0.4	0.6	0.7	-0.8	-0.8	-0.8	-0.8	-0.8	0.7	0.4
Delay disc. indifference point, 4s delay	0.2	0.3	0.5	0.5	0.5	0.5	0.5	0.6	-0.7	0.1
Delay disc. indifference point, 8s delay	0.9	1.4	1.7	1.1	1.1	1.2	1.2	1.3	-1.3	-1.2
Indifference point function ln k	0.4	1.1	2.1	-1.0	-1.0	-1.0	-1.0	-1.0	1.0	1.4
Indifference point function log k	0.4	1.1	2.1	-1.0	-1.0	-1.0	-1.0	-1.0	1.0	1.4
Patch foraging total patch changes 0 sec	0.2	0.6	1.2	0.7	0.7	0.7	0.7	0.6	-0.6	-1.1
Patch foraging total patch changes 12 sec	0.2	0.3	0.3	0.5	0.5	0.5	0.5	0.6	-0.5	-0.4
Patch foraging total patch changes 18 sec	1.0	2.3	2.5	1.6	1.5	1.5	1.5	1.5	-1.3	-1.6
Patch foraging total patch changes 24 sec	1.0	3.3	5.1	1.8	1.8	1.8	1.8	1.7	-1.6	-2.3
Patch foraging total patch changes 6 sec	3.1	5.2	5.6	2.3	2.3	2.3	2.3	2.4	-2.3	-2.1
Patch foraging time to switch 0 sec	0.6	2.3	2.5	-1.6	-1.6	-1.6	-1.6	-1.5	1.5	1.3
Patch foraging water rate 0 sec	0.7	2.7	3.0	1.7	1.7	1.7	1.7	1.7	-1.6	-1.3
Patch foraging water rate 12 sec	0.1	0.5	1.0	-0.6	-0.6	-0.6	-0.6	-0.6	0.8	1.0
Patch foraging water rate 18 sec	0.4	0.9	1.8	-0.8	-0.8	-0.8	-0.8	-0.8	0.9	1.3
Patch foraging water rate 24 sec	0.2	0.2	0.3	0.5	0.5	0.5	0.5	0.5	-0.5	0.3
Patch foraging water rate 6 sec	0.8	1.2	1.5	1.2	1.2	1.2	1.2	1.1	-1.1	-0.4
Seeking ratio, delayed vs. immediate footshock	1.7	2.4	3.0	1.6	1.6	1.6	1.6	1.7	-1.7	-1.1
Distance traveled before self-admin	2.1	4.5	4.8	2.2	2.2	2.2	2.2	2.2	-2.2	-1.7
Distance traveled after self-admin	0.1	0.1	0.2	0.3	0.3	0.3	0.3	0.3	-0.4	-0.4
Extensor digitorum longus weight	0.7	2.6	3.0	-1.7	-1.7	-1.7	-1.7	-1.7	1.6	1.0
Bone: elastic displacement	2.6	3.3	3.5	1.9	1.9	1.9	1.9	1.9	-1.8	-1.6
Bone: elastic work	8.0	10.5	11.2	3.3	3.4	3.3	3.3	3.3	-3.2	-2.8
Bone: endosteal estimation	0.0	0.1	0.3	0.1	0.1	0.1	0.1	0.1	-0.2	0.5
Bone: endosteal perimeter	0.0	0.1	0.5	-0.1	-0.1	-0.1	-0.1	-0.0	-0.1	0.7
Epididymis fat weight	5.5	27.8	30.9	-5.3	-5.3	-5.3	-5.3	-5.1	5.1	5.6
Delta time in closed arm before/after self-admin	2.9	2.8	2.9	1.7	1.7	1.7	1.7	1.6	-1.7	-1.5
Delta time in open arm before/after self-admin	4.9	5.7	6.2	-2.5	-2.5	-2.5	-2.5	-2.4	2.4	2.1
Diff in mean of infusions in LGA sessions	0.4	0.6	0.7	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	0.6
Delay discount exponential model param	1.2	1.6	2.2	-1.3	-1.2	-1.3	-1.3	-1.5	1.5	0.8
Extinction: sum of active levers before priming	0.7	1.0	1.3	-1.1	-1.1	-1.1	-1.1	-1.1	1.0	-0.1
Active lever presses in extinction session 6	0.4	0.4	0.7	-0.6	-0.5	-0.6	-0.6	-0.8	0.7	-0.3
Bone: final force	0.3	0.5	0.6	0.7	0.7	0.7	0.7	0.8	-0.8	-0.7
Bone: final moment	0.4	0.6	0.7	0.8	0.8	0.8	0.8	0.8	-0.8	-0.6
Food consumed during 24 hour testing period	0.1	0.2	0.3	0.4	0.4	0.4	0.4	0.3	-0.2	-0.6
Glucose	1.5	2.3	2.4	1.5	1.5	1.5	1.5	1.5	-1.5	-1.5
Heart weight	1.5	2.4	3.1	-1.6	-1.6	-1.7	-1.7	-1.6	1.8	0.7
Delay discount hyperbolic model param	1.7	2.1	2.7	-1.5	-1.4	-1.5	-1.5	-1.6	1.6	1.0
Intermittent access intake day 1-15 change	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	-0.3	0.1	-0.1
Intermittent access intake escalation	0.0	0.1	0.1	-0.3	-0.3	-0.3	-0.3	-0.4	0.2	-0.0
Intermittent access intake escalation 2	0.1	0.2	0.3	0.4	0.4	0.4	0.4	0.4	-0.5	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.3	0.4	0.4	0.4	0.4	0.4	-0.5	-0.3
Intermitt. access day 15 inactive lever presses	0.1	0.6	0.8	0.8	0.8	0.8	0.8	0.7	-0.9	-0.3
Intermitt. access escalation Index	0.4	1.2	2.0	-1.1	-1.1	-1.0	-1.0	-0.9	1.0	1.4
Intermittent access day 1 total infusions	0.0	0.1	0.2	-0.4	-0.4	-0.3	-0.3	-0.3	0.2	0.4
Intermittent access day 15 total infusions	0.4	0.9	1.1	-1.0	-1.0	-1.0	-1.0	-1.0	0.8	0.6
Intermittent access terminal intake (last 3 days)	0.6	1.0	1.2	-1.1	-1.1	-1.1	-1.0	-1.0	0.8	0.9
Intermittent access total infusions	0.2	0.2	0.3	-0.5	-0.6	-0.5	-0.5	-0.5	0.3	-0.1
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	0.0	-0.1	-0.4
Intermittent access day 15 total locomotion	0.1	0.3	0.4	-0.7	-0.7	-0.7	-0.6	-0.6	0.5	0.1
Intermittent access total locomotion	0.4	0.4	0.6	-0.8	-0.8	-0.7	-0.7	-0.7	0.6	0.1
Intermittent access standard deviation	0.0	0.0	0.0	0.0	0.0	0.1	0.1	0.1	-0.2	0.1
Left kidney weight	0.0	0.2	0.3	-0.5	-0.5	-0.5	-0.5	-0.4	0.5	0.5
Right kidney weight	0.1	0.7	1.0	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	1.0
Cocaine induced anxiety	0.1	0.2	0.2	0.4	0.4	0.4	0.4	0.5	-0.4	-0.0
Post-drug Anxiety	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.5	-0.5	0.6	0.1
Baseline Anxiety	0.3	0.4	0.6	-0.6	-0.6	-0.7	-0.7	-0.8	0.8	-0.3
Tail length	0.4	1.9	2.6	-1.4	-1.4	-1.4	-1.3	-1.3	1.3	1.6
Length with tail	0.6	2.9	5.0	-1.6	-1.6	-1.6	-1.6	-1.5	1.6	2.2
Length without tail	0.2	1.3	3.3	-1.0	-1.1	-1.0	-1.0	-0.8	0.9	1.8
Times rat made contact with spout	0.1	0.1	0.5	0.1	0.2	0.1	0.1	0.0	-0.0	-0.7
Lifetime Intake	0.3	0.4	0.5	-0.7	-0.7	-0.7	-0.6	-0.6	0.4	0.5
Liver weight, left	4.7	8.2	8.4	-2.9	-2.9	-2.9	-2.9	-2.9	2.8	2.8
Liver weight, right	3.9	6.9	7.1	-2.7	-2.7	-2.7	-2.7	-2.6	2.6	2.5
Locomotor activity	0.0	0.0	0.0	0.2	0.2	0.2	0.2	0.2	-0.2	0.1
Locomotor testing distance	0.0	0.1	0.2	0.3	0.3	0.3	0.3	0.4	-0.3	-0.0
Locomotor testing rearing	0.0	0.1	0.2	0.2	0.2	0.2	0.2	0.2	-0.2	-0.5
Locomotion in novel chamber	2.5	3.4	4.3	1.9	1.8	1.9	1.9	2.0	-2.1	-1.3
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.0	-0.0	-0.1	-0.3
Fecal boli incidents, locomotor time 1	0.8	2.1	2.5	-1.5	-1.5	-1.5	-1.5	-1.5	1.6	0.9
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	0.4	0.4	0.5	0.5	0.6	-0.8	-0.1
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.1	-0.1	0.1	-0.4
Bouts of movement, locomotor time 1	0.3	0.5	0.6	0.7	0.7	0.7	0.7	0.8	-0.7	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.3	-0.3	0.0
Rest time, locomotor task time 1	0.1	0.2	0.3	-0.5	-0.5	-0.5	-0.5	-0.6	0.5	0.2
Distance moved, locomotor task time 1	0.2	0.5	0.7	0.7	0.7	0.7	0.7	0.8	-0.8	-0.3
Vertical activity count, locomotor time 1	0.0	0.2	0.4	0.4	0.4	0.4	0.5	0.6	-0.6	-0.3
Time >=10cm from walls, locomotor time 2	0.3	0.8	1.1	-1.0	-1.0	-1.0	-0.9	-0.8	0.8	0.4
Bouts of movement, locomotor time 2	0.1	0.3	0.4	0.6	0.6	0.6	0.6	0.6	-0.6	-0.2
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.3	0.3	0.3	0.3	0.2	-0.2	-0.1
Rest time, locomotor task time 2	0.1	0.2	0.8	-0.1	-0.0	-0.1	-0.2	-0.4	0.3	-0.9
Distance moved, locomotor task time 2	0.3	0.5	0.8	0.6	0.6	0.7	0.7	0.9	-0.8	0.0
Vertical activity count, locomotor time 2	0.4	0.8	1.5	0.8	0.7	0.9	0.9	1.2	-1.2	0.5
Light reinforcement 1	0.0	0.0	0.0	0.2	0.1	0.2	0.2	0.2	-0.2	-0.1
Light reinforcement 2	0.2	0.5	0.6	0.8	0.8	0.8	0.8	0.7	-0.8	-0.4
Bone: marrow area	0.0	0.1	0.3	0.1	0.1	0.1	0.1	0.1	-0.2	0.5
Bone: maximum diameter	0.3	0.6	0.8	0.8	0.8	0.8	0.8	0.9	-0.9	-0.4
Bone: maximum force	0.5	1.0	1.1	1.0	1.0	1.0	1.0	1.0	-1.1	-0.7
Bone: maximum moment	0.6	1.1	1.4	1.1	1.1	1.1	1.1	1.1	-1.2	-0.8
Mean time between licks in bursts	0.1	0.8	0.9	-0.9	-0.9	-0.9	-0.9	-0.9	0.9	0.9
Mean num. licks in bursts	0.1	0.4	0.5	-0.7	-0.7	-0.7	-0.7	-0.7	0.7	0.2
Cd content in liver	0.7	0.8	1.1	0.9	0.9	1.0	1.0	1.0	-1.1	-0.0
Co content in liver	0.4	0.5	1.0	0.6	0.6	0.6	0.6	0.7	-0.7	-1.0
Cu content in liver	1.4	1.7	1.9	1.4	1.4	1.3	1.3	1.2	-1.2	-1.2
Fe content in liver	1.9	2.3	2.6	-1.6	-1.6	-1.6	-1.6	-1.6	1.5	1.0
K content in liver	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	-0.3	0.3	-0.0
Mg content in liver	0.6	0.7	1.3	0.8	0.8	0.8	0.8	0.7	-0.8	-1.1
Mn content in liver	0.2	0.2	0.4	0.5	0.5	0.5	0.5	0.4	-0.4	-0.6
Na content in liver	0.0	0.0	0.1	-0.1	-0.2	-0.1	-0.1	0.1	-0.0	0.4
Rb content in liver	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	-0.3	0.2	0.0
Se content in liver	0.6	0.7	1.0	0.8	0.8	0.8	0.8	0.7	-0.8	-1.0
Sr content in liver	0.5	0.4	0.4	-0.7	-0.7	-0.7	-0.7	-0.6	0.7	0.6
Zn content in liver	0.4	0.4	0.5	-0.7	-0.6	-0.6	-0.6	-0.6	0.6	0.7
Bone: minimum diameter	0.1	0.1	0.2	0.4	0.4	0.4	0.4	0.4	-0.4	-0.2
Time in familiar zone, hab. session 1	0.3	0.3	0.5	0.6	0.6	0.6	0.6	0.6	-0.7	-0.2
Time in novel zone, hab. session 1	0.1	0.2	0.2	-0.4	-0.4	-0.4	-0.4	-0.5	0.5	0.2
Total zone transitions, hab. session 1	0.0	0.1	0.1	0.2	0.2	0.2	0.2	0.3	-0.3	0.2
Total locomotion distance, hab. session 1	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.3	-0.3	-0.0
Locomotion velocity, hab. session 1	0.3	0.4	0.5	0.7	0.7	0.7	0.7	0.7	-0.7	-0.3
Time in familiar zone, hab. session 2	0.1	0.2	0.4	0.4	0.4	0.4	0.4	0.3	-0.3	-0.6
Time in novel zone, hab. session 2	0.1	0.2	0.3	0.4	0.4	0.4	0.4	0.5	-0.5	0.1
Total zone transitions, hab. session 2	0.2	0.3	0.3	-0.6	-0.6	-0.6	-0.6	-0.6	0.6	0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.3	0.3	0.3	0.2	0.2	0.2	-0.1	-0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.3	0.3	0.3	0.3	0.2	-0.2	-0.5
Novel to familiar place preference ratio	0.7	0.9	0.9	-1.0	-1.0	-1.0	-0.9	-0.9	0.9	0.9
Novelty place preference	0.9	1.2	1.2	-1.1	-1.1	-1.1	-1.1	-1.1	1.0	1.0
Time in novel zone, NPP test	1.0	1.2	1.3	-1.1	-1.1	-1.1	-1.1	-1.1	1.1	1.0
Total zone transitions, NPP test	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.1	0.1	0.1
Total locomotion distance, NPP test	0.8	1.1	1.2	1.1	1.1	1.1	1.1	1.0	-1.0	-1.0
Locomotion velocity, NPP test	0.9	1.3	1.5	1.2	1.2	1.2	1.2	1.2	-1.1	-1.0
Intraocular pressure	0.9	1.5	1.6	1.3	1.3	1.3	1.3	1.2	-1.2	-1.0
Delta distance traveled before/after self-admin	2.8	3.1	3.4	-1.8	-1.8	-1.8	-1.8	-1.8	1.8	1.3
Delta ambulatory time before/after self-admin	1.4	2.4	2.7	-1.6	-1.6	-1.6	-1.6	-1.6	1.6	1.1
Parametrial fat weight	6.0	14.2	15.3	-3.9	-3.9	-3.9	-3.9	-3.8	3.9	3.1
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.2	-0.1	-0.2	-0.2	-0.2	0.2	0.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.1	0.1	-0.0
Pavlov. Cond. change in total contacts	0.5	0.5	1.2	0.6	0.6	0.6	0.6	0.6	-0.6	-1.1
Pavlov. Cond. index score	0.1	0.1	0.3	0.2	0.2	0.2	0.2	0.2	-0.2	-0.6
Pavlov. Cond. latency score	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.1	-0.1	-0.5
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.1	0.1	0.1	0.1	0.2	-0.2	-0.6
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	-0.4	-0.4	-0.4	-0.4	-0.5	0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	0.5	0.5	0.5	0.5	0.4	-0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	0.3	0.3	0.3	0.3	0.4	-0.4	-0.7
Pavlov. Cond. response bias	0.0	0.0	0.2	0.1	0.1	0.1	0.1	0.2	-0.2	-0.4
Pavlov. Cond. lever latency	2.3	3.2	3.6	-1.9	-1.9	-1.9	-1.9	-1.8	1.7	1.3
Pavlov. Cond. magazine entry latency	0.2	0.3	0.3	0.5	0.5	0.5	0.5	0.5	-0.5	-0.5
Pavlov. Cond. change in total contacts	0.8	2.0	2.2	1.5	1.5	1.5	1.5	1.4	-1.4	-1.1
Pavlov. Cond. index score	1.9	2.9	3.2	1.8	1.8	1.8	1.8	1.7	-1.7	-1.4
Pavlov. Cond. latency score	2.1	3.4	3.7	1.9	1.9	1.9	1.9	1.8	-1.8	-1.6
Pavlov. Cond. lever contacts	1.2	1.7	2.0	1.4	1.4	1.4	1.4	1.3	-1.2	-1.1
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.2	-0.2	-0.2	-0.2	-0.1	0.2	0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.7	0.7	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.4	2.2	2.4	1.5	1.5	1.5	1.5	1.5	-1.5	-1.3
Pavlov. Cond. response bias	1.1	1.5	1.7	1.3	1.3	1.3	1.3	1.2	-1.2	-0.8
Time in closed arm before self-admin	0.9	1.6	2.6	-1.3	-1.3	-1.3	-1.3	-1.0	1.2	1.6
Time in closed arm after self-admin	0.9	1.1	1.6	1.0	1.0	1.0	1.0	1.3	-1.2	0.3
Time in open arm before self-admin	1.5	1.8	2.9	1.3	1.4	1.3	1.3	1.1	-1.1	-1.7
Time in open arm after self-admin	1.0	1.1	1.3	-1.1	-1.1	-1.1	-1.1	-1.1	1.1	0.6
Bone: periosteal estimation	0.3	0.8	1.0	0.9	0.9	0.9	0.9	1.0	-1.0	-0.3
Bone: periosteal perimeter	0.3	0.5	0.8	0.7	0.7	0.7	0.7	0.8	-0.9	-0.1
Bone: post-yield work	0.1	0.3	0.3	-0.6	-0.6	-0.6	-0.5	-0.5	0.4	0.4
Progressive ratio test 1 active lever presses	0.4	0.7	0.9	0.8	0.8	0.8	0.8	0.9	-0.9	-0.9
Progressive ratio test 1 breakpoint	0.5	0.8	1.0	0.8	0.8	0.9	0.9	0.9	-1.0	-0.9
Progressive ratio test 1 inactive lever presses	0.9	2.3	3.3	1.5	1.5	1.6	1.6	1.7	-1.8	-0.8
Progressive ratio test 2 active lever presses	0.4	0.5	1.1	0.6	0.6	0.6	0.6	0.6	-0.7	-1.0
Progressive ratio test 2 breakpoint	0.4	0.5	1.0	0.6	0.6	0.6	0.6	0.6	-0.7	-1.0
Progressive ratio test 2 inactive lever presses	0.0	0.2	0.3	0.4	0.4	0.4	0.4	0.4	-0.6	-0.2
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	-0.2	0.1	-0.4
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	-0.3	0.2	-0.3
Sum of active levers in priming session hrs 5-6	1.5	1.4	1.8	-1.3	-1.2	-1.3	-1.3	-1.3	1.3	0.3
Progressive ratio	0.0	0.1	0.3	-0.3	-0.3	-0.3	-0.3	-0.4	0.5	-0.4
Food seeking constrained by brief footshock	0.2	0.2	0.7	-0.3	-0.3	-0.3	-0.3	-0.3	0.3	0.8
Seeking ratio, punishment vs. effort	0.1	0.2	0.4	0.4	0.4	0.4	0.4	0.5	-0.7	0.6
Retroperitoneal fat weight	0.6	2.6	5.9	-1.5	-1.5	-1.5	-1.5	-1.3	1.4	2.4
Reaction time number correct	0.4	1.4	1.8	-1.2	-1.2	-1.2	-1.2	-1.1	1.2	1.3
Reaction time mean minus median	0.0	0.3	0.4	-0.6	-0.6	-0.6	-0.6	-0.6	0.5	0.5
Reaction time mean minus median AUC	0.3	2.2	2.3	-1.5	-1.5	-1.5	-1.5	-1.5	1.4	1.4
Reaction time num false alarms	4.3	7.4	8.0	2.8	2.8	2.8	2.8	2.7	-2.7	-2.2
Reaction time num false alarms AUC	3.3	7.5	8.1	2.9	2.9	2.8	2.8	2.8	-2.7	-2.2
Reaction time trials correct on left	0.4	1.4	1.8	-1.2	-1.2	-1.2	-1.2	-1.1	1.2	1.3
Reaction time trials on left	0.4	1.4	1.8	-1.2	-1.2	-1.2	-1.2	-1.1	1.2	1.3
Reaction time mean	0.5	1.2	1.4	-1.0	-1.0	-1.1	-1.1	-1.1	1.1	1.2
Reaction time mean AUC	0.4	0.9	1.1	-0.9	-0.9	-0.9	-0.9	-1.0	0.9	1.0
Median of all reaction times	0.5	0.9	1.2	-0.9	-0.9	-0.9	-0.9	-1.0	0.9	1.1
Reaction time omissions	1.0	1.6	1.7	-1.3	-1.3	-1.3	-1.3	-1.3	1.2	1.2
Reaction time false alarm rate	5.8	8.0	8.5	2.9	2.9	2.9	2.9	2.8	-2.9	-2.5
Reaction time premature initiation rate	0.1	0.2	0.4	-0.5	-0.5	-0.4	-0.4	-0.4	0.4	0.6
Reaction time premature initiations	0.2	0.6	1.0	-0.8	-0.8	-0.8	-0.8	-0.7	0.7	1.0
Std. dev. reaction times	0.4	1.2	1.4	-1.1	-1.1	-1.1	-1.1	-1.2	1.0	1.0
Reaction time trials completed	0.4	1.4	1.8	-1.2	-1.2	-1.2	-1.2	-1.1	1.2	1.3
Reaction time trials AUC	0.3	1.2	1.4	-1.1	-1.1	-1.1	-1.1	-1.0	1.1	1.2
Run reversals in cocaine runway, females	0.2	0.3	1.5	-0.3	-0.3	-0.2	-0.2	-0.3	0.3	1.2
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	-0.2	0.0	0.3
Latency to leave start box in cocaine runway	0.2	0.3	1.1	0.5	0.5	0.4	0.4	0.2	0.0	-1.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.5	0.1	0.1	0.0	0.0	-0.2	0.4	-0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.2	-0.1	-0.2
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	-0.1	-0.0	0.3
Total sessions with >9 infusions	0.2	0.3	0.9	-0.5	-0.5	-0.4	-0.4	-0.3	0.2	1.0
Short access day 1 total inactive lever presses	2.0	3.9	5.0	-2.0	-2.0	-2.0	-2.0	-1.9	1.6	2.2
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.1	0.1	0.1	0.1	0.2	-0.4	0.2
Short access day 1 total infusions	0.3	0.6	1.7	-0.7	-0.7	-0.7	-0.7	-0.5	0.3	1.3
Short access day 10 total infusions	0.2	0.3	0.7	-0.5	-0.5	-0.5	-0.4	-0.3	0.3	0.8
Short access total infusions	0.1	0.1	0.6	-0.2	-0.3	-0.2	-0.2	-0.0	-0.1	0.8
Short access day 1 locomotion	0.0	0.1	0.2	0.2	0.2	0.2	0.2	0.3	-0.4	0.0
Short access day 10 total locomotion	0.2	0.7	0.8	0.8	0.8	0.8	0.9	0.9	-0.9	-0.9
Short access total locomotion	0.5	0.7	1.1	0.8	0.8	0.8	0.8	0.9	-1.0	-0.7
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.3	0.3	0.3	0.4	0.3	-0.4	-0.6
Compulsive drug intake	0.7	1.0	1.1	-1.0	-1.0	-1.0	-1.0	-1.0	1.0	0.9
One hour access (shock baseline)	0.1	0.3	0.6	0.4	0.4	0.5	0.5	0.4	-0.5	-0.8
Social response proportion	1.9	2.4	2.6	-1.6	-1.6	-1.6	-1.6	-1.5	1.4	1.5
Social responses	1.8	2.4	2.5	-1.6	-1.6	-1.6	-1.6	-1.5	1.5	1.6
Social time	1.0	1.5	1.9	-1.4	-1.4	-1.3	-1.3	-1.2	1.1	1.0
Soleus weight	2.1	6.1	6.7	-2.6	-2.6	-2.6	-2.6	-2.5	2.5	1.8
Bone: stiffness	1.6	2.8	3.1	-1.7	-1.8	-1.7	-1.7	-1.7	1.6	1.5
Tibialis anterior weight	2.6	8.8	9.6	-3.1	-3.1	-3.1	-3.1	-3.1	3.1	2.1
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	-0.0	-0.1	0.3
Time to tail flick, vehicle, after self-admin	0.3	0.5	0.8	0.7	0.7	0.7	0.7	0.9	-0.8	-0.3
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	-0.1	0.1	0.4
Time to tail flick, test, after self-admin	0.4	0.4	1.9	0.5	0.5	0.4	0.4	0.2	0.0	-1.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.4	1.1	0.5	0.6	0.5	0.5	0.5	-0.3	-1.0
Delta time to tail flick, test, before/after SA	0.4	0.4	0.8	0.7	0.7	0.7	0.7	0.5	-0.5	-0.9
Tibia length	0.0	0.1	0.1	0.3	0.3	0.3	0.3	0.3	-0.4	-0.2
Ambulatory time before self-admin	0.8	2.4	3.2	1.6	1.5	1.6	1.6	1.7	-1.8	-0.8
Ambulatory time after self-admin	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0	0.0	-0.1	0.0
Bone: tissue strength	1.7	1.8	1.9	1.3	1.3	1.3	1.3	1.4	-1.4	-1.2
Total heroin consumption	3.6	4.2	5.8	-2.1	-2.1	-2.2	-2.2	-2.4	2.3	0.2
Bone: trabecular number	2.6	4.9	5.5	-2.3	-2.3	-2.3	-2.3	-2.3	2.3	1.6
Bone: trabecular spacing	0.3	0.4	0.5	0.6	0.6	0.6	0.6	0.7	-0.7	-0.5
Bone: trabecular thickness	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	-0.0	0.0
Bone: trabecular tissue density	1.0	1.7	1.9	1.4	1.4	1.4	1.4	1.4	-1.4	-0.7
Water consumed over 24 hours	0.0	0.0	0.0	0.1	0.2	0.1	0.1	0.1	-0.1	-0.1
Number of responses in last shaping day	1.0	1.3	1.7	1.2	1.2	1.2	1.2	1.2	-1.3	-0.7