Hub : Genes

Ppp2r5d

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	Ppp2r5d	0.02	0.02	2.0e-03	0	0.01	0.01	0	6.7e-02	2.9e-02	2.4e-02	7.9e-02
2	Adipose	gene expression	Ppp2r5d	0.04	0.04	1.7e-03	0.03	0.02	0.02	0.02	5.1e-04	2.6e-03	2.5e-03	9.9e-04
3	NAcc	gene expression	Ppp2r5d	0.05	0.03	5.6e-09	0.06	0.05	0.05	0.06	4.0e-10	6.3e-08	3.5e-08	4.7e-09
4	Liver	gene expression	Ppp2r5d	0.16	0.07	0.0e+00	0.18	0.21	0.2	0.2	3.9e-19	7.6e-23	1.2e-21	3.1e-22

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.5	0.8	1.5	1.2	0.9	-0.9	0.2
Area under the delay curve	7.9	9.1	11.1	2.4	3.3	-3.0	-3.3
BMI with tail	3.4	11.7	14.2	-3.8	-3.7	3.6	2.5
BMI without tail	5.0	15.2	16.7	-4.1	-4.1	4.0	3.4
Body weight	4.6	20.3	21.8	-4.5	-4.7	4.6	4.3
Weight adjusted by age	0.3	0.4	0.5	-0.7	-0.6	0.7	0.7
Bone surface	1.2	2.2	3.6	1.9	1.6	-1.7	-0.4
Bone volume	0.6	1.0	1.7	1.3	1.1	-1.1	-0.1
Breakpoint value in progressive ratio session	0.1	0.1	0.4	-0.2	0.0	-0.2	-0.7
Number of licking bursts	2.9	4.7	6.9	-1.4	-2.2	2.3	2.6
Context. condit. distance diff. score	0.3	0.4	0.6	-0.7	-0.5	0.5	0.8
Locomotion velocity, session 1	0.5	0.5	1.2	-1.1	-0.7	0.6	-0.2
Locomotion distance, session 1	2.2	2.8	3.8	-2.0	-1.7	1.6	1.4
Locomotion velocity, session 2	5.6	6.5	11.5	-3.4	-2.4	2.5	1.7
Locomotion distance, session 2	1.2	1.7	2.6	-1.6	-1.4	1.3	0.8
Locomotion velocity, session 3	0.5	0.6	1.3	-1.1	-0.7	0.7	-0.1
Locomotion distance, session 3	1.1	1.1	2.0	0.7	1.0	-1.0	-1.4
Stereotopy head waving bouts, day 3	1.2	1.4	1.9	-0.9	-1.3	1.4	1.2
Stereotopy head waving duration, day 3	1.7	2.0	2.7	-1.4	-1.6	1.6	1.1
Locomotion velocity, session 7	0.3	0.3	0.6	-0.8	-0.4	0.4	-0.5
Locomotion distance, session 7	0.1	0.2	0.3	-0.5	-0.3	0.2	-0.5
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	-0.2	-0.3	0.4	0.7
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.3	0.2	-0.1	0.4
Locomotion velocity, session 8	0.6	0.7	1.5	-1.2	-0.7	0.7	0.6
Locomotion distance, session 8	1.1	1.6	2.2	-1.5	-1.3	1.2	1.1
Degree of sensitization distance	1.8	1.9	2.4	-1.6	-1.5	1.4	0.9
Degree of sensitization stereotypy	0.3	0.4	0.6	0.6	0.8	-0.6	-0.2
Conditioned locomotion	2.4	2.8	5.2	1.1	1.5	-1.6	-2.3
Cocaine response after cond. corrected	0.2	0.2	0.4	0.6	0.4	-0.5	-0.4
Cocaine response after cond. not corrected	0.4	0.5	0.6	0.7	0.6	-0.8	-0.8
Cocaine response before conditioning	0.1	0.1	0.2	-0.4	-0.1	-0.1	-0.4
Saline control response	0.1	0.1	0.3	-0.5	0.1	-0.1	-0.2
Bone: connectivity density	1.0	1.5	3.6	1.9	1.1	-1.2	0.2
Bone: cortical apparent density	0.4	0.5	0.8	0.4	0.8	-0.8	-0.9
Bone: cortical area	0.7	1.1	2.9	-1.7	-0.7	0.9	0.4
Bone: cortical porosity	0.1	0.1	0.1	0.2	-0.3	0.3	0.4
Bone: cortical porosity	0.0	0.1	0.1	-0.0	-0.3	0.3	0.1
Bone: cortical thickness	0.8	1.3	3.4	-1.8	-0.8	0.9	0.4
Bone: cortical thickness	0.0	0.0	0.1	0.4	0.1	-0.1	0.2
Bone: cortical tissue density	0.4	0.6	0.8	0.4	0.8	-0.9	-0.9
Condit. Reinf. active minus inactive responses	1.5	1.7	2.0	-1.3	-1.4	1.4	1.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	-0.3	-0.6	0.5	0.7
Condit. Reinf. active responses	2.9	3.6	3.9	-2.0	-2.0	1.9	1.7
Condit. Reinf. inactive responses	2.3	2.8	3.2	-1.7	-1.8	1.7	1.6
Incentive salience index mean	2.3	2.8	4.2	-2.0	-1.7	1.7	1.2
Condit. Reinf. lever presses	4.0	5.7	8.4	-2.9	-2.3	2.3	1.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	0.1	-0.1	0.2	0.7
Condit. Reinf. active-inactive response ratio	0.9	1.1	2.4	-0.4	-0.9	0.9	1.6
Condit. Reinf. active responses	0.0	0.0	0.1	-0.0	0.0	0.1	0.4
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.2	0.3	-0.2	-0.5
Condit. Reinf. lever presses	0.7	0.9	1.7	-0.7	-0.8	0.9	1.3
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	0.0	0.1	-0.0	0.3
Conditioned reinforcement - actives	0.5	0.8	2.1	-0.4	0.7	-0.8	-1.4
Conditioned reinforcement - inactives	0.3	0.4	0.8	-0.9	-0.7	0.7	0.2
Conditioned locomotion	0.1	0.2	0.2	-0.3	-0.5	0.4	0.4
Patch foraging indifference point 0 sec	0.7	1.3	1.7	-1.0	-1.1	1.3	1.0
Patch foraging indifference point AUC	0.7	1.0	2.6	-1.6	-0.8	0.8	-0.3
Delay disc. indifference point, 0s delay	2.6	2.9	3.9	2.0	1.5	-1.3	-1.8
Delay disc. indifference point, 16s delay	10.4	11.4	13.4	2.5	3.7	-3.6	-3.6
Delay disc. indifference point, 2s delay	3.8	4.2	5.1	1.9	2.1	-1.9	-2.3
Delay disc. indifference point, 24s delay	0.9	1.0	1.4	0.9	1.2	-1.1	-0.7
Delay disc. indifference point, 4s delay	3.7	3.9	7.8	0.7	2.0	-1.8	-2.8
Delay disc. indifference point, 8s delay	4.6	5.3	6.9	1.7	2.5	-2.3	-2.6
Indifference point function ln k	0.5	0.8	1.4	1.2	0.7	-0.9	-0.8
Indifference point function log k	0.5	0.8	1.4	1.2	0.7	-0.9	-0.8
Patch foraging total patch changes 0 sec	0.9	1.6	2.1	-1.2	-1.3	1.5	1.1
Patch foraging total patch changes 12 sec	1.2	1.6	4.0	-2.0	-0.9	1.2	0.3
Patch foraging total patch changes 18 sec	1.0	1.5	2.8	-1.7	-1.2	1.3	0.4
Patch foraging total patch changes 24 sec	0.5	0.9	1.6	-1.2	-1.0	1.1	0.4
Patch foraging total patch changes 6 sec	2.5	3.7	5.8	-2.4	-1.8	1.9	1.5
Patch foraging time to switch 0 sec	2.8	5.8	8.2	2.9	2.6	-2.6	-1.2
Patch foraging water rate 0 sec	1.8	3.7	7.4	-2.7	-1.9	2.0	0.0
Patch foraging water rate 12 sec	3.4	7.2	8.8	-3.0	-2.9	2.8	1.8
Patch foraging water rate 18 sec	1.0	1.5	2.0	-1.4	-1.3	1.4	0.7
Patch foraging water rate 24 sec	1.5	2.1	2.8	-1.6	-1.5	1.7	0.8
Patch foraging water rate 6 sec	0.2	0.3	0.5	-0.7	-0.5	0.5	-0.5
Seeking ratio, delayed vs. immediate footshock	1.7	2.0	2.4	1.6	1.5	-1.5	-1.0
Distance traveled before self-admin	0.0	0.1	0.1	-0.3	-0.3	0.2	-0.1
Distance traveled after self-admin	1.6	1.9	2.6	-1.3	-1.6	1.6	1.0
Extensor digitorum longus weight	0.1	0.4	0.7	-0.7	-0.9	0.6	0.3
Bone: elastic displacement	0.5	0.5	0.8	0.5	0.9	-0.8	-0.6
Bone: elastic work	0.1	0.1	0.4	-0.3	0.1	0.1	0.6
Bone: endosteal estimation	0.4	0.8	1.3	1.1	0.9	-0.9	-0.6
Bone: endosteal perimeter	0.0	0.1	0.1	-0.2	-0.1	0.3	0.3
Epididymis fat weight	3.1	10.6	12.3	-2.9	-3.3	3.3	3.5
Delta time in closed arm before/after self-admin	0.3	0.3	1.0	0.5	-0.1	-0.0	1.0
Delta time in open arm before/after self-admin	0.3	0.3	0.9	0.5	0.4	-0.2	-1.0
Diff in mean of infusions in LGA sessions	0.6	0.8	1.4	-1.2	-1.0	0.8	0.3
Delay discount exponential model param	7.8	8.7	10.4	-2.2	-3.2	3.0	3.2
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.0	-0.0	0.0	-0.6
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.6	-0.3	0.3	-0.4
Bone: final force	0.6	0.9	1.4	-1.2	-0.7	0.9	1.0
Bone: final moment	0.5	0.8	1.6	-1.3	-0.6	0.8	0.6
Food consumed during 24 hour testing period	0.4	0.5	1.0	-1.0	-0.7	0.8	0.0
Glucose	6.8	10.6	12.0	-3.3	-3.5	3.3	2.9
Heart weight	0.2	0.3	1.0	-1.0	-0.3	0.4	0.2
Delay discount hyperbolic model param	7.0	7.8	9.5	-2.1	-3.1	2.8	3.1
Intermittent access intake day 1-15 change	0.0	0.1	0.3	-0.6	0.0	0.1	-0.0
Intermittent access intake escalation	0.0	0.1	0.2	-0.5	0.1	0.0	0.0
Intermittent access intake escalation 2	0.1	0.2	0.2	-0.4	0.4	-0.3	-0.5
Intermitt. access day 1 inactive lever presses	0.4	1.4	2.6	-0.4	-1.2	1.2	1.6
Intermitt. access day 15 inactive lever presses	0.4	0.7	1.2	-0.6	-1.1	0.8	0.8
Intermitt. access escalation Index	0.0	0.1	0.2	0.5	-0.0	-0.1	-0.1
Intermittent access day 1 total infusions	0.4	0.7	1.2	-0.6	-1.1	0.8	0.8
Intermittent access day 15 total infusions	0.3	0.4	0.6	-0.6	-0.8	0.5	0.6
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.0
Intermittent access total infusions	0.1	0.2	0.3	-0.4	-0.6	0.3	0.3
Intermittent access day 1 locomotion	0.7	0.9	1.5	-0.3	-1.2	0.9	1.1
Intermittent access day 15 total locomotion	0.6	1.1	1.2	-1.0	-1.1	1.1	1.0
Intermittent access total locomotion	0.6	0.7	1.1	-0.3	-1.0	0.9	1.0
Intermittent access standard deviation	1.1	2.2	2.8	1.7	1.6	-1.7	-0.9
Left kidney weight	1.5	7.1	9.4	-3.1	-2.7	2.7	2.0
Right kidney weight	1.4	6.6	11.0	-3.3	-2.5	2.7	1.4
Cocaine induced anxiety	0.2	0.2	0.7	0.0	-0.2	0.3	0.9
Post-drug Anxiety	0.1	0.2	0.5	-0.2	-0.1	0.2	0.7
Baseline Anxiety	0.4	0.5	1.0	0.2	0.6	-0.8	-1.0
Tail length	1.6	6.1	7.9	-2.3	-2.4	2.4	2.8
Length with tail	1.3	5.6	9.9	-1.7	-2.2	2.2	3.1
Length without tail	0.8	2.4	3.9	-1.3	-1.5	1.4	2.0
Times rat made contact with spout	4.9	5.6	6.6	-1.9	-2.4	2.5	2.6
Lifetime Intake	0.0	0.0	0.1	0.2	0.0	-0.3	-0.2
Liver weight, left	0.4	0.6	1.9	-1.4	-0.5	0.4	-0.3
Liver weight, right	2.8	5.0	7.5	-2.7	-2.1	2.1	1.9
Locomotor activity	2.6	4.0	5.0	-2.0	-1.9	2.0	2.2
Locomotor testing distance	2.3	4.2	5.7	-1.8	-2.0	1.9	2.4
Locomotor testing rearing	2.1	4.3	5.7	-2.4	-2.1	2.2	1.4
Locomotion in novel chamber	0.8	1.0	1.3	0.7	1.1	-1.0	-1.1
Locomotion in novel chamber post-restriction	0.8	1.3	3.1	-0.1	0.8	-1.2	-1.8
Fecal boli incidents, locomotor time 1	0.5	0.7	1.9	-0.1	0.7	-0.7	-1.4
Change in fecal boli incidents, locomotor task	0.2	0.1	0.4	0.0	0.3	-0.3	-0.7
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.5	-0.6	-0.6	0.7	0.0
Bouts of movement, locomotor time 1	0.5	0.5	2.1	1.4	0.0	0.0	0.2
Total resting periods, locomotor time 1	0.4	0.5	0.8	0.9	-0.5	0.6	0.7
Rest time, locomotor task time 1	0.8	1.0	1.9	1.4	0.9	-0.7	-0.9
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.4	-0.2	0.2	0.5
Vertical activity count, locomotor time 1	0.2	0.5	0.9	0.1	0.9	-0.9	-0.6
Time >=10cm from walls, locomotor time 2	0.3	0.5	0.8	-0.7	-0.8	0.9	0.1
Bouts of movement, locomotor time 2	0.3	0.4	0.5	-0.6	-0.6	0.7	0.7
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.1	-0.2	0.4	0.5
Rest time, locomotor task time 2	0.7	0.8	2.1	1.5	0.8	-0.6	-0.4
Distance moved, locomotor task time 2	0.9	1.1	1.5	-0.8	-1.2	1.2	0.9
Vertical activity count, locomotor time 2	0.1	0.2	0.3	-0.2	0.4	-0.5	-0.6
Light reinforcement 1	1.3	3.2	4.2	-2.1	-1.8	1.9	1.2
Light reinforcement 2	2.3	3.6	4.9	-1.5	-1.9	1.9	2.2
Bone: marrow area	0.4	0.8	1.2	1.1	0.9	-0.9	-0.6
Bone: maximum diameter	0.3	0.5	1.2	-1.1	-0.5	0.7	0.0
Bone: maximum force	0.1	0.2	0.5	-0.3	-0.1	0.2	0.7
Bone: maximum moment	0.0	0.1	0.2	-0.4	0.0	0.1	0.4
Mean time between licks in bursts	1.1	2.8	5.1	2.3	1.6	-1.7	-0.9
Mean num. licks in bursts	0.5	0.8	1.4	0.5	0.9	-0.8	-1.2
Cd content in liver	1.9	2.1	3.0	1.7	1.3	-1.4	-1.4
Co content in liver	0.1	0.1	0.4	0.7	0.2	-0.3	-0.1
Cu content in liver	0.3	0.4	1.0	0.1	0.5	-0.5	-1.0
Fe content in liver	0.1	0.1	0.4	-0.6	-0.3	0.1	0.0
K content in liver	0.4	0.4	0.9	0.7	0.2	-0.2	1.0
Mg content in liver	0.1	0.1	0.2	0.2	0.5	-0.4	-0.0
Mn content in liver	0.3	0.3	0.5	0.2	-0.5	0.7	0.7
Na content in liver	0.9	1.0	2.2	-1.5	-0.7	0.8	0.7
Rb content in liver	3.6	4.2	5.6	1.5	2.2	-2.4	-2.1
Se content in liver	0.7	0.8	1.3	-0.8	-1.2	1.0	0.3
Sr content in liver	0.9	0.8	1.2	-1.1	-0.9	0.9	0.5
Zn content in liver	1.6	1.8	2.7	0.9	1.4	-1.4	-1.6
Bone: minimum diameter	0.3	0.5	0.8	-0.9	-0.6	0.7	0.5
Time in familiar zone, hab. session 1	0.6	0.6	1.4	-1.2	-0.8	0.7	-0.1
Time in novel zone, hab. session 1	1.0	1.0	2.2	1.5	0.9	-0.9	-0.5
Total zone transitions, hab. session 1	4.1	5.7	6.2	-2.5	-2.5	2.5	2.1
Total locomotion distance, hab. session 1	4.2	6.0	8.2	-2.9	-2.5	2.5	1.7
Locomotion velocity, hab. session 1	3.8	5.4	7.7	-2.8	-2.4	2.3	1.6
Time in familiar zone, hab. session 2	1.6	1.7	2.2	1.4	1.5	-1.5	-0.8
Time in novel zone, hab. session 2	0.2	0.2	0.4	-0.4	-0.6	0.6	0.0
Total zone transitions, hab. session 2	3.0	3.9	6.0	-1.4	-1.9	1.9	2.5
Total locomotion distance, hab. session 2	3.1	4.1	4.5	-1.7	-2.1	2.1	2.1
Locomotion velocity, hab. session 2	2.5	3.3	3.9	-1.5	-1.9	1.9	2.0
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.3	-0.3	0.4	0.2
Novelty place preference	0.0	0.0	0.0	-0.2	0.0	0.1	0.0
Time in novel zone, NPP test	0.0	0.0	0.0	-0.1	0.0	0.1	-0.1
Total zone transitions, NPP test	6.6	9.6	10.4	-3.2	-3.0	3.1	3.0
Total locomotion distance, NPP test	6.1	8.3	8.6	-2.9	-2.9	2.9	2.8
Locomotion velocity, NPP test	6.9	9.7	10.2	-3.2	-3.0	3.1	3.2
Intraocular pressure	0.8	1.2	2.5	1.6	0.7	-0.8	-1.1
Delta distance traveled before/after self-admin	2.2	2.3	3.1	-1.0	-1.6	1.8	1.6
Delta ambulatory time before/after self-admin	2.5	3.1	4.2	-1.4	-1.8	2.0	1.7
Parametrial fat weight	4.2	9.9	11.5	-2.8	-3.4	3.2	3.2
Pavlov. Cond. lever latency	2.9	3.6	7.7	2.8	1.7	-1.7	-1.0
Pavlov. Cond. magazine entry latency	0.7	0.8	2.3	-1.5	-0.7	0.6	-0.4
Pavlov. Cond. change in total contacts	1.8	1.9	3.3	-1.8	-1.5	1.4	0.5
Pavlov. Cond. index score	2.8	3.5	7.8	-2.8	-1.7	1.7	0.6
Pavlov. Cond. latency score	2.0	2.6	6.5	-2.6	-1.3	1.4	0.3
Pavlov. Cond. lever contacts	3.2	3.8	7.5	-2.7	-1.8	1.8	1.0
Pavlov. Cond. magazine entry number	2.3	2.9	6.0	2.4	1.7	-1.6	-0.5
Pavlov. Cond. intertrial magazine entries	1.0	1.1	1.6	1.3	1.1	-1.0	-0.8
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.1	6.9	-2.6	-1.6	1.6	0.5
Pavlov. Cond. response bias	3.7	4.6	8.3	-2.9	-2.1	2.1	1.1
Pavlov. Cond. lever latency	3.0	4.1	5.5	1.9	1.9	-1.9	-2.3
Pavlov. Cond. magazine entry latency	2.8	3.4	4.0	-1.8	-1.8	1.8	2.0
Pavlov. Cond. change in total contacts	2.7	4.4	6.1	-2.0	-1.9	2.0	2.5
Pavlov. Cond. index score	4.9	6.5	7.6	-2.6	-2.4	2.5	2.7
Pavlov. Cond. latency score	5.3	7.0	8.0	-2.6	-2.6	2.6	2.8
Pavlov. Cond. lever contacts	3.4	4.6	6.2	-2.1	-2.0	2.0	2.5
Pavlov. Cond. magazine entry number	1.1	1.3	1.7	1.3	1.0	-1.0	-1.3
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.2	0.1	-0.0	-0.3
Pavlov. Cond. lever-magazine prob. diff.	5.1	6.8	8.0	-2.6	-2.5	2.5	2.8
Pavlov. Cond. response bias	1.5	2.1	3.5	-1.4	-1.2	1.2	1.9
Time in closed arm before self-admin	0.1	0.1	0.3	0.6	-0.0	-0.2	0.3
Time in closed arm after self-admin	0.7	0.7	2.1	0.7	-0.5	0.3	1.5
Time in open arm before self-admin	2.2	2.4	4.7	-2.2	-1.5	1.5	0.8
Time in open arm after self-admin	0.4	0.4	1.0	-1.0	-0.4	0.6	-0.4
Bone: periosteal estimation	0.1	0.1	0.3	-0.6	-0.2	0.3	0.0
Bone: periosteal perimeter	1.0	1.8	2.9	-1.7	-1.1	1.3	1.1
Bone: post-yield work	0.1	0.2	0.6	0.2	-0.2	0.3	0.8
Progressive ratio test 1 active lever presses	0.8	1.0	1.5	-0.6	-1.1	1.0	1.2
Progressive ratio test 1 breakpoint	0.8	0.9	1.3	-0.5	-1.1	1.0	1.1
Progressive ratio test 1 inactive lever presses	0.7	1.0	1.3	-1.1	-1.2	1.0	0.7
Progressive ratio test 2 active lever presses	2.3	2.7	3.5	-1.8	-1.9	1.6	1.2
Progressive ratio test 2 breakpoint	2.7	3.1	3.9	-2.0	-1.9	1.7	1.3
Progressive ratio test 2 inactive lever presses	0.6	1.0	1.7	-1.0	-1.3	0.9	0.7
Incentive Sensitization - Responses	1.3	1.8	2.9	-1.7	-1.4	1.2	0.9
Incentive Sensitization - Breakpoint	1.4	1.8	2.9	-1.7	-1.4	1.3	0.9
Sum of active levers in priming session hrs 5-6	0.7	0.7	2.2	-0.6	0.2	-0.3	-1.5
Progressive ratio	0.4	0.6	1.0	0.3	1.0	-0.8	-0.7
Food seeking constrained by brief footshock	0.1	0.2	0.5	-0.0	-0.3	0.4	0.7
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	-0.1	-0.8	0.6	0.6
Retroperitoneal fat weight	2.6	11.1	14.7	-3.8	-3.6	3.4	2.3
Reaction time number correct	0.3	0.5	1.6	-0.2	0.3	-0.6	-1.3
Reaction time mean minus median	0.0	0.1	0.2	-0.1	0.5	-0.4	-0.1
Reaction time mean minus median AUC	0.1	0.4	0.6	0.6	0.8	-0.7	-0.1
Reaction time num false alarms	0.6	0.9	1.1	0.9	1.0	-1.0	-0.8
Reaction time num false alarms AUC	0.4	0.7	0.8	0.7	0.9	-0.9	-0.8
Reaction time trials correct on left	0.3	0.5	1.6	-0.2	0.3	-0.6	-1.3
Reaction time trials on left	0.2	0.4	1.4	-0.2	0.3	-0.5	-1.2
Reaction time mean	0.2	0.4	0.8	0.7	0.2	-0.2	0.9
Reaction time mean AUC	0.3	0.5	1.2	0.8	0.2	-0.1	1.1
Median of all reaction times	0.3	0.5	1.2	0.8	0.0	-0.0	1.1
Reaction time omissions	0.4	0.5	0.8	-0.8	-0.6	0.6	0.9
Reaction time false alarm rate	0.5	0.7	1.0	1.0	0.9	-0.8	-0.3
Reaction time premature initiation rate	1.0	1.4	1.6	-1.2	-1.2	1.3	1.0
Reaction time premature initiations	0.6	1.1	2.1	-1.4	-1.1	1.1	0.4
Std. dev. reaction times	0.1	0.2	0.4	0.3	0.4	-0.3	0.6
Reaction time trials completed	0.2	0.4	1.4	-0.2	0.3	-0.5	-1.2
Reaction time trials AUC	0.2	0.3	1.1	-0.4	0.1	-0.3	-1.0
Run reversals in cocaine runway, females	1.1	1.1	2.0	-1.4	-1.0	1.0	0.5
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.1	-0.4	0.4	-0.1
Latency to leave start box in cocaine runway	1.4	1.6	2.1	-1.4	-1.3	1.2	0.9
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.3	-0.5	0.4	0.6
Latency to leave start box in cocaine runway, M	4.3	4.0	5.6	-2.4	-2.1	2.1	1.3
Std. dev. time between licks in bursts	1.3	1.7	2.0	1.4	1.2	-1.2	-1.3
Total sessions with >9 infusions	0.1	0.1	0.3	0.3	0.2	-0.3	-0.5
Short access day 1 total inactive lever presses	0.2	0.2	0.3	-0.5	-0.6	0.5	0.3
Short access day 10 total inactive lever presses	0.1	0.2	0.4	-0.4	-0.6	0.4	0.4
Short access day 1 total infusions	0.3	0.4	0.6	0.6	0.5	-0.6	-0.8
Short access day 10 total infusions	0.0	0.1	0.1	0.4	-0.1	-0.2	0.0
Short access total infusions	0.9	1.2	1.6	1.2	0.9	-1.2	-1.0
Short access day 1 locomotion	0.1	0.2	0.4	0.6	0.4	-0.4	-0.3
Short access day 10 total locomotion	0.5	1.0	2.3	1.5	0.8	-0.9	-0.2
Short access total locomotion	0.8	0.9	1.3	1.2	0.8	-1.0	-0.8
One hour access (0.3 mA shock)	0.3	0.3	0.8	-0.4	0.5	-0.3	-0.9
Compulsive drug intake	0.2	0.2	0.5	0.1	0.4	-0.3	-0.7
One hour access (shock baseline)	0.3	0.4	0.6	-0.8	-0.6	0.5	0.5
Social response proportion	0.8	0.9	1.4	0.8	1.2	-1.1	-0.5
Social responses	1.4	1.8	2.8	0.9	1.7	-1.6	-1.0
Social time	1.3	1.8	4.1	0.0	1.3	-1.2	-2.0
Soleus weight	0.5	1.5	2.4	-1.6	-1.2	1.2	0.9
Bone: stiffness	0.0	0.0	0.0	0.0	0.1	0.1	0.2
Tibialis anterior weight	0.2	0.7	1.2	-0.7	-1.1	0.8	0.8
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.8	0.0	0.2	-0.9	-0.5
Time to tail flick, vehicle, after self-admin	1.7	2.3	3.3	1.6	1.8	-1.7	-0.5
Time to tail flick, test, before self-admin	3.9	4.0	6.4	1.1	2.0	-2.1	-2.5
Time to tail flick, test, after self-admin	1.4	1.4	2.2	0.9	1.5	-1.3	-1.0
Delta time to tail flick, vehicle, before/after SA	0.8	0.7	1.4	0.9	1.2	-0.7	-0.3
Delta time to tail flick, test, before/after SA	1.1	1.2	3.5	-0.2	-0.6	0.8	1.9
Tibia length	2.7	7.5	10.1	-3.2	-2.8	2.9	1.9
Ambulatory time before self-admin	0.1	0.2	0.6	-0.0	0.2	-0.2	-0.7
Ambulatory time after self-admin	1.8	2.1	2.9	-1.5	-1.5	1.7	0.9
Bone: tissue strength	0.1	0.1	0.2	-0.1	0.4	-0.2	-0.3
Total heroin consumption	0.2	0.2	0.3	-0.6	-0.6	0.3	0.3
Bone: trabecular number	0.4	0.7	1.0	1.0	0.9	-1.0	-0.1
Bone: trabecular spacing	0.4	0.5	1.0	-1.0	-0.7	0.8	-0.2
Bone: trabecular thickness	0.9	1.2	2.0	1.4	1.2	-1.1	-0.3
Bone: trabecular tissue density	0.5	0.8	2.9	-0.0	0.2	-0.3	-1.7
Water consumed over 24 hours	2.7	3.6	5.5	-2.3	-1.8	1.9	1.3
Number of responses in last shaping day	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.1