Hub : Genes

Ppp1r13b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Ppp1r13b 0.13 0.09 7.7e-06 0.1 0.1 0.09 0.1 3.9e-05 5.1e-05 8.3e-05 4.4e-05
2 PL gene expression Ppp1r13b 0.02 0.02 7.5e-03 0.02 0.02 0.02 0.02 1.7e-03 5.9e-03 3.6e-03 3.4e-03
3 Adipose isoform ratio NM_001395106.1 0.02 0.03 7.9e-03 0.01 0.01 0.01 0.01 1.9e-02 1.2e-02 1.6e-02 1.9e-02
4 Brain alternative TSS XM_039112417.1 0.07 0.06 9.8e-08 0.07 0.08 0.08 0.08 7.2e-07 2.9e-08 7.2e-08 7.3e-08
5 Brain alternative TSS XM_039112417.1 0.07 0.05 8.6e-08 0.07 0.09 0.08 0.08 8.0e-07 2.6e-08 5.3e-08 7.1e-08
6 Adipose isoform ratio XM_039112418.1 0.04 0.03 6.6e-05 0.02 0.03 0.03 0.03 9.0e-04 3.2e-04 6.7e-04 6.4e-04
7 PL mRNA stability Ppp1r13b 0.07 0.05 1.4e-09 0.09 0.09 0.09 0.09 9.0e-10 5.2e-10 6.2e-10 8.6e-10
8 BLA mRNA stability Ppp1r13b 0.08 0.06 2.3e-05 0.07 0.09 0.07 0.06 1.7e-04 1.7e-05 1.3e-04 2.8e-04
9 Liver mRNA stability Ppp1r13b 0.13 0.07 0.0e+00 0.14 0.14 0.14 0.14 7.8e-15 4.6e-15 6.2e-15 8.8e-15
10 Adipose intron excision ratio chr6_130898641_130901979 0.04 0.04 7.0e-04 0.02 0.01 0.02 0.01 2.6e-03 8.2e-03 4.6e-03 8.0e-03
11 OFC isoform ratio XM_039112418.1 0.17 0.14 1.3e-03 0.1 0.1 0.1 0.11 2.5e-03 2.5e-03 1.9e-03 1.5e-03
12 NAcc mRNA stability Ppp1r13b 0.06 0.04 2.9e-10 0.08 0.09 0.09 0.09 1.8e-09 1.5e-10 1.5e-10 1.8e-10
13 Adipose alternative TSS XM_039112419.1 0.07 0.08 1.6e-05 0.04 0.04 0.04 0.04 3.1e-05 7.1e-05 5.0e-05 4.9e-05
14 Adipose alternative TSS XM_039112419.1 0.08 0.1 6.5e-06 0.04 0.04 0.04 0.04 1.4e-05 4.1e-05 2.6e-05 2.3e-05
15 Adipose alternative TSS XM_039112417.1 0.08 0.07 2.8e-06 0.04 0.04 0.04 0.05 1.3e-05 1.6e-05 1.5e-05 7.7e-06
16 Adipose alternative TSS XM_039112417.1 0.08 0.07 2.5e-06 0.04 0.04 0.04 0.05 1.2e-05 1.6e-05 1.5e-05 7.8e-06
17 OFC isoform ratio NM_001395106.1 0.16 0.13 3.0e-03 0.08 0.06 0.01 0.07 6.7e-03 1.4e-02 1.4e-01 1.0e-02
18 Brain isoform ratio NM_001395106.1 0.04 0.03 4.7e-04 0.04 0.03 0.02 0.03 1.2e-04 1.5e-03 4.9e-03 1.6e-03
19 Brain isoform ratio XM_039112418.1 0.05 0.04 7.0e-05 0.04 0.03 0.02 0.03 3.0e-04 6.1e-04 6.7e-03 7.8e-04
20 Adipose mRNA stability Ppp1r13b 0.07 0.05 2.6e-05 0.03 0.04 0.04 0.04 2.2e-04 4.0e-05 8.9e-05 8.8e-05
21 Brain mRNA stability Ppp1r13b 0.12 0.1 3.1e-08 0.09 0.08 0.09 0.09 1.5e-08 3.4e-08 1.1e-08 8.6e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.00.10.2-0.5-0.3-0.20.20.20.20.20.20.2-0.10.1-0.30.30.30.30.30.20.2-0.2-0.30.3
Area under the delay curve0.10.10.3-0.5-0.2-0.20.20.20.20.20.20.3-0.30.3-0.20.40.40.40.40.30.3-0.3-0.30.3
BMI with tail2.47.88.7-2.6-2.5-2.92.92.92.92.92.92.9-3.03.0-2.92.62.62.72.72.92.8-2.8-2.72.9
BMI without tail0.61.21.5-0.7-0.4-1.21.21.21.21.21.21.2-1.21.2-1.20.90.91.01.01.21.2-1.2-1.21.1
Body weight0.21.02.41.61.41.1-1.1-1.1-1.1-0.9-0.9-0.91.3-1.31.0-0.9-0.9-0.9-0.9-0.5-0.60.60.4-0.6
Weight adjusted by age0.10.10.50.70.20.4-0.4-0.4-0.4-0.3-0.3-0.30.6-0.60.2-0.1-0.1-0.1-0.1-0.20.0-0.0-0.0-0.2
Bone surface0.00.10.3-0.6-0.4-0.20.20.20.20.20.20.2-0.20.2-0.30.30.30.30.30.10.3-0.3-0.20.1
Bone volume0.00.10.1-0.4-0.2-0.20.20.20.20.20.20.2-0.20.2-0.20.30.30.30.30.10.3-0.3-0.20.1
Breakpoint value in progressive ratio session0.10.10.3-0.4-0.1-0.40.40.40.40.30.20.2-0.60.6-0.10.20.20.10.1-0.0-0.00.00.0-0.1
Number of licking bursts0.00.10.20.10.10.0-0.0-0.0-0.0-0.1-0.1-0.1-0.20.2-0.0-0.5-0.5-0.4-0.4-0.3-0.20.20.3-0.3
Context. condit. distance diff. score2.42.95.01.91.81.9-1.9-1.9-1.9-1.7-1.7-1.82.2-2.21.9-1.2-1.2-1.3-1.3-1.5-1.61.61.3-1.5
Locomotion velocity, session 10.20.20.50.40.40.4-0.4-0.4-0.5-0.5-0.5-0.50.4-0.40.4-0.4-0.4-0.4-0.4-0.6-0.50.50.5-0.7
Locomotion distance, session 10.50.60.8-0.9-0.9-0.80.80.80.80.80.70.7-0.90.9-0.90.90.90.90.90.50.6-0.6-0.60.6
Locomotion velocity, session 20.00.00.10.30.30.1-0.1-0.1-0.1-0.1-0.0-0.0-0.00.00.1-0.3-0.3-0.2-0.2-0.0-0.10.10.00.2
Locomotion distance, session 20.30.40.5-0.6-0.6-0.60.60.60.60.70.60.6-0.60.6-0.70.70.70.70.70.70.6-0.6-0.70.6
Locomotion velocity, session 30.10.20.3-0.5-0.4-0.40.40.40.40.40.40.4-0.40.4-0.40.50.50.50.50.40.2-0.2-0.40.5
Locomotion distance, session 30.00.00.00.00.00.1-0.1-0.1-0.1-0.1-0.1-0.10.0-0.0-0.00.00.00.00.0-0.1-0.20.20.1-0.1
Stereotopy head waving bouts, day 30.10.20.30.40.40.3-0.3-0.3-0.3-0.3-0.4-0.30.2-0.20.4-0.4-0.4-0.4-0.4-0.5-0.40.40.5-0.5
Stereotopy head waving duration, day 30.20.30.40.60.60.4-0.4-0.4-0.4-0.5-0.5-0.50.4-0.40.5-0.6-0.6-0.6-0.6-0.6-0.50.50.6-0.6
Locomotion velocity, session 70.20.20.6-0.8-0.7-0.50.40.40.50.50.50.5-0.40.4-0.50.40.40.40.40.70.4-0.4-0.50.6
Locomotion distance, session 70.70.91.4-1.1-1.0-0.90.90.90.91.01.01.0-0.80.8-1.00.90.90.90.91.21.0-1.0-1.00.9
Stereotopy head waving bouts, day 71.11.21.41.11.01.2-1.2-1.2-1.2-1.1-1.1-1.11.1-1.11.1-1.1-1.1-1.1-1.1-1.1-1.11.11.0-1.0
Stereotopy head waving duration, day 70.40.50.50.70.60.7-0.7-0.7-0.7-0.7-0.7-0.70.7-0.70.7-0.7-0.7-0.7-0.7-0.7-0.70.70.6-0.6
Locomotion velocity, session 80.40.40.90.60.70.8-0.8-0.8-0.8-0.7-0.6-0.71.0-1.00.7-0.5-0.5-0.5-0.5-0.4-0.60.60.3-0.5
Locomotion distance, session 80.10.10.40.30.20.3-0.3-0.2-0.3-0.1-0.1-0.20.7-0.70.20.40.40.40.40.20.1-0.1-0.3-0.0
Degree of sensitization distance0.10.10.3-0.5-0.5-0.40.40.40.40.40.40.4-0.40.4-0.40.10.10.20.20.40.3-0.3-0.20.3
Degree of sensitization stereotypy0.20.20.30.30.20.5-0.5-0.5-0.5-0.5-0.5-0.50.4-0.40.4-0.5-0.5-0.5-0.5-0.5-0.50.50.4-0.4
Conditioned locomotion1.41.72.11.21.31.3-1.3-1.3-1.3-1.3-1.3-1.31.2-1.21.2-1.5-1.5-1.4-1.4-1.3-1.31.31.2-1.1
Cocaine response after cond. corrected0.60.71.3-0.7-0.7-1.01.01.01.00.90.90.9-1.21.2-1.10.30.30.50.50.80.8-0.8-0.60.9
Cocaine response after cond. not corrected2.02.23.1-1.4-1.4-1.61.61.61.61.61.61.6-1.81.8-1.51.21.21.21.21.51.5-1.5-1.31.5
Cocaine response before conditioning2.32.74.4-1.7-1.7-1.61.61.61.61.61.71.6-1.41.4-1.12.12.11.81.71.81.7-1.7-1.71.4
Saline control response0.10.20.4-0.5-0.5-0.30.30.30.30.40.40.4-0.10.10.10.50.50.20.20.60.6-0.6-0.60.0
Bone: connectivity density0.10.10.60.20.30.5-0.5-0.5-0.5-0.4-0.4-0.40.7-0.70.4-0.1-0.1-0.1-0.1-0.2-0.30.30.1-0.2
Bone: cortical apparent density8.310.912.13.23.33.3-3.3-3.3-3.3-3.4-3.4-3.42.9-2.93.4-3.3-3.3-3.4-3.4-3.4-3.53.53.4-3.3
Bone: cortical area0.71.02.00.81.10.8-0.8-0.8-0.8-1.0-1.0-1.00.4-0.41.0-1.0-1.0-1.1-1.1-1.4-1.11.11.3-1.4
Bone: cortical porosity0.10.10.40.20.10.4-0.4-0.3-0.3-0.2-0.2-0.20.7-0.70.20.00.00.00.0-0.1-0.10.1-0.10.0
Bone: cortical porosity0.10.20.4-0.3-0.4-0.10.20.20.20.30.30.30.2-0.2-0.30.50.50.50.50.40.5-0.5-0.60.5
Bone: cortical thickness0.61.02.10.81.00.7-0.7-0.8-0.8-1.0-1.0-1.00.2-0.20.9-1.1-1.1-1.1-1.1-1.4-1.21.21.4-1.4
Bone: cortical thickness0.70.81.21.01.10.9-0.9-0.9-0.9-0.9-0.9-0.90.8-0.80.9-0.8-0.8-0.8-0.8-0.8-0.90.90.9-1.1
Bone: cortical tissue density8.511.112.33.33.33.3-3.3-3.3-3.3-3.4-3.4-3.42.9-2.93.4-3.4-3.4-3.4-3.4-3.4-3.53.53.4-3.3
Condit. Reinf. active minus inactive responses0.60.70.9-0.7-0.7-0.90.90.90.90.80.80.8-0.90.9-0.80.90.90.90.90.90.8-0.8-0.70.7
Condit. Reinf. active-inactive response ratio2.83.03.4-1.7-1.7-1.81.81.81.71.71.71.7-1.71.7-1.81.91.91.81.81.71.7-1.7-1.61.6
Condit. Reinf. active responses0.20.20.4-0.2-0.2-0.50.50.50.50.50.50.5-0.50.5-0.40.50.50.50.50.60.4-0.4-0.40.4
Condit. Reinf. inactive responses1.82.12.91.71.71.4-1.4-1.4-1.4-1.4-1.5-1.51.2-1.21.5-1.5-1.5-1.5-1.5-1.5-1.51.51.5-1.5
Incentive salience index mean0.60.70.9-0.8-0.8-0.90.90.90.90.80.80.8-0.90.9-0.91.01.00.90.90.70.7-0.7-0.70.7
Condit. Reinf. lever presses0.10.20.3-0.4-0.4-0.40.40.40.40.40.40.4-0.50.5-0.40.50.50.50.50.10.3-0.3-0.20.3
Condit. Reinf. active minus inactive responses0.50.71.40.80.80.9-0.9-0.9-0.9-0.8-0.8-0.81.2-1.20.8-0.8-0.8-0.7-0.7-0.6-0.70.70.6-0.5
Condit. Reinf. active-inactive response ratio0.50.51.20.80.90.9-0.9-0.8-0.8-0.8-0.8-0.81.1-1.10.4-0.6-0.6-0.3-0.3-0.6-0.70.70.6-0.2
Condit. Reinf. active responses0.00.00.20.10.20.2-0.2-0.2-0.2-0.1-0.1-0.10.4-0.40.4-0.2-0.2-0.2-0.20.20.0-0.0-0.10.0
Condit. Reinf. inactive responses0.40.50.9-0.7-0.6-0.80.80.80.80.90.90.9-0.80.8-0.20.50.50.30.31.00.9-0.9-0.90.5
Condit. Reinf. lever presses1.11.52.6-1.2-1.1-1.21.21.21.21.31.41.3-0.80.8-0.81.21.21.11.11.61.5-1.5-1.61.2
Condit. Reinf. lever reinforcers received0.10.10.30.30.20.3-0.2-0.2-0.2-0.1-0.1-0.10.6-0.60.4-0.3-0.3-0.2-0.20.20.1-0.1-0.20.1
Conditioned reinforcement - actives2.32.33.21.61.81.5-1.5-1.5-1.5-1.5-1.5-1.51.5-1.51.7-1.6-1.6-1.6-1.6-1.5-1.41.41.4-1.5
Conditioned reinforcement - inactives0.40.50.80.60.90.7-0.7-0.7-0.7-0.7-0.7-0.70.7-0.70.8-0.7-0.7-0.8-0.8-0.6-0.60.60.6-0.7
Conditioned locomotion0.50.60.9-0.5-0.4-0.70.80.80.80.80.80.8-0.50.5-0.50.90.90.80.80.80.8-0.8-1.00.7
Patch foraging indifference point 0 sec3.86.16.92.62.52.5-2.5-2.5-2.5-2.5-2.4-2.42.5-2.52.6-2.6-2.6-2.6-2.6-2.2-2.22.22.3-2.1
Patch foraging indifference point AUC2.42.83.61.31.61.6-1.6-1.6-1.6-1.7-1.7-1.71.2-1.21.7-1.7-1.7-1.7-1.7-1.8-1.81.81.9-1.9
Delay disc. indifference point, 0s delay0.10.10.20.40.20.4-0.4-0.4-0.4-0.4-0.4-0.40.4-0.40.4-0.2-0.2-0.3-0.3-0.2-0.30.30.3-0.3
Delay disc. indifference point, 16s delay0.00.00.1-0.3-0.0-0.20.20.20.20.20.20.2-0.30.30.10.30.30.30.30.10.1-0.1-0.10.2
Delay disc. indifference point, 2s delay0.20.30.6-0.8-0.7-0.50.50.50.50.40.40.4-0.80.8-0.50.60.60.50.50.40.4-0.4-0.10.2
Delay disc. indifference point, 24s delay0.20.20.4-0.6-0.5-0.40.40.40.40.30.30.3-0.60.6-0.50.30.30.30.30.10.3-0.3-0.20.2
Delay disc. indifference point, 4s delay0.20.20.30.40.50.5-0.5-0.5-0.5-0.4-0.4-0.40.6-0.60.5-0.4-0.4-0.4-0.4-0.2-0.40.40.3-0.3
Delay disc. indifference point, 8s delay0.20.20.4-0.6-0.2-0.20.20.30.30.30.40.4-0.20.2-0.30.50.50.50.50.50.5-0.5-0.50.5
Indifference point function ln k0.81.12.11.31.11.2-1.1-1.1-1.1-1.0-1.0-1.01.5-1.51.0-1.1-1.1-1.0-1.0-0.8-0.70.70.6-0.8
Indifference point function log k0.81.12.11.31.11.2-1.1-1.1-1.1-1.0-1.0-1.01.5-1.51.0-1.1-1.1-1.0-1.0-0.8-0.70.70.6-0.8
Patch foraging total patch changes 0 sec4.36.97.72.82.72.7-2.7-2.7-2.7-2.7-2.6-2.62.7-2.72.8-2.8-2.8-2.8-2.8-2.3-2.42.42.4-2.2
Patch foraging total patch changes 12 sec4.05.16.32.12.12.3-2.3-2.3-2.3-2.3-2.3-2.32.0-2.02.3-2.5-2.5-2.5-2.5-2.2-2.32.32.2-2.1
Patch foraging total patch changes 18 sec1.62.12.81.11.11.3-1.4-1.4-1.4-1.5-1.4-1.40.9-0.91.5-1.7-1.7-1.7-1.7-1.5-1.71.71.6-1.3
Patch foraging total patch changes 24 sec0.20.20.30.40.50.5-0.5-0.5-0.5-0.5-0.5-0.50.4-0.40.6-0.6-0.6-0.6-0.6-0.4-0.50.50.5-0.3
Patch foraging total patch changes 6 sec2.13.14.41.92.11.7-1.7-1.7-1.7-1.8-1.7-1.71.4-1.41.9-1.9-1.9-1.9-1.9-1.6-1.71.71.8-1.5
Patch foraging time to switch 0 sec11.317.418.9-4.2-4.3-4.14.14.14.14.24.24.2-4.04.0-4.34.24.24.24.24.24.2-4.2-4.14.2
Patch foraging water rate 0 sec19.030.533.55.75.85.5-5.6-5.6-5.6-5.6-5.6-5.65.2-5.25.7-5.5-5.5-5.5-5.5-5.4-5.55.55.5-5.5
Patch foraging water rate 12 sec10.315.819.84.44.54.1-4.0-4.0-4.0-4.0-3.9-3.94.2-4.24.1-3.9-3.9-3.9-3.9-3.7-3.73.73.6-3.7
Patch foraging water rate 18 sec5.16.87.62.72.62.7-2.7-2.7-2.7-2.7-2.7-2.62.6-2.62.7-2.5-2.5-2.6-2.6-2.5-2.62.62.5-2.5
Patch foraging water rate 24 sec4.15.77.62.82.52.5-2.4-2.4-2.5-2.4-2.4-2.42.5-2.52.5-2.3-2.3-2.3-2.3-2.3-2.32.32.2-2.4
Patch foraging water rate 6 sec5.17.49.03.02.92.7-2.7-2.7-2.7-2.7-2.7-2.72.6-2.62.8-2.8-2.8-2.8-2.8-2.5-2.72.72.6-2.6
Seeking ratio, delayed vs. immediate footshock0.30.30.80.70.40.6-0.6-0.6-0.6-0.6-0.6-0.60.4-0.40.4-0.3-0.3-0.4-0.4-0.9-0.70.70.5-0.7
Distance traveled before self-admin0.10.10.5-0.7-0.1-0.50.50.40.40.30.30.4-0.70.7-0.3-0.1-0.1-0.1-0.10.30.3-0.30.00.1
Distance traveled after self-admin0.50.50.70.70.70.8-0.7-0.7-0.7-0.7-0.7-0.70.7-0.70.7-0.9-0.9-0.8-0.8-0.7-0.70.70.6-0.7
Extensor digitorum longus weight6.425.127.95.15.15.3-5.2-5.2-5.2-5.1-5.1-5.15.3-5.35.2-4.8-4.8-4.8-4.8-5.0-4.74.74.5-4.9
Bone: elastic displacement0.50.60.80.70.70.8-0.8-0.8-0.8-0.8-0.8-0.80.6-0.60.7-0.8-0.8-0.8-0.8-0.9-0.70.70.8-0.9
Bone: elastic work0.10.10.30.30.30.3-0.3-0.3-0.3-0.3-0.3-0.30.1-0.10.2-0.3-0.3-0.3-0.3-0.4-0.20.20.4-0.5
Bone: endosteal estimation0.10.30.6-0.5-0.5-0.40.50.50.40.60.50.5-0.20.2-0.40.70.70.70.70.60.7-0.7-0.80.5
Bone: endosteal perimeter0.00.00.00.00.2-0.20.20.20.20.20.10.1-0.20.2-0.00.20.20.20.20.00.2-0.2-0.1-0.1
Epididymis fat weight4.310.111.5-2.9-2.9-3.13.23.23.23.23.33.2-3.03.0-3.23.13.13.23.23.33.2-3.2-3.23.4
Delta time in closed arm before/after self-admin0.00.00.10.10.1-0.00.10.10.10.10.20.10.2-0.2-0.20.10.10.20.20.30.2-0.2-0.30.4
Delta time in open arm before/after self-admin0.50.51.20.30.60.6-0.6-0.6-0.6-0.6-0.6-0.60.4-0.41.1-0.6-0.6-0.9-0.9-0.7-0.60.60.7-1.1
Diff in mean of infusions in LGA sessions0.00.00.1-0.0-0.0-0.10.10.10.1-0.0-0.00.0-0.30.3-0.1-0.2-0.2-0.2-0.1-0.1-0.20.20.3-0.1
Delay discount exponential model param0.10.10.20.40.10.1-0.1-0.1-0.1-0.2-0.2-0.20.1-0.10.1-0.3-0.3-0.3-0.3-0.3-0.30.30.2-0.2
Extinction: sum of active levers before priming0.00.00.1-0.10.2-0.20.20.20.20.10.10.1-0.30.3-0.10.20.20.20.20.0-0.00.00.00.0
Active lever presses in extinction session 61.51.52.21.41.51.3-1.2-1.2-1.2-1.2-1.2-1.21.5-1.51.3-1.0-1.0-1.0-1.0-1.1-1.11.11.0-1.2
Bone: final force0.20.40.70.60.70.6-0.6-0.6-0.6-0.6-0.7-0.70.6-0.60.7-0.5-0.5-0.5-0.5-0.8-0.60.60.6-0.8
Bone: final moment0.30.50.80.70.80.7-0.7-0.7-0.7-0.7-0.7-0.70.7-0.70.7-0.5-0.5-0.5-0.5-0.9-0.60.60.7-0.9
Food consumed during 24 hour testing period0.20.20.70.40.40.5-0.5-0.5-0.5-0.4-0.4-0.50.6-0.60.8-0.1-0.1-0.3-0.3-0.4-0.30.30.2-0.7
Glucose0.71.01.71.00.90.9-0.9-0.9-0.9-1.0-1.0-1.00.6-0.61.0-1.0-1.0-1.1-1.1-1.0-1.21.21.3-1.1
Heart weight0.00.00.10.20.10.1-0.1-0.0-0.0-0.00.00.00.1-0.10.0-0.2-0.2-0.2-0.20.30.2-0.2-0.20.2
Delay discount hyperbolic model param0.10.10.30.50.30.2-0.2-0.2-0.2-0.2-0.2-0.20.3-0.30.2-0.4-0.4-0.3-0.3-0.3-0.30.30.2-0.3
Intermittent access intake day 1-15 change1.41.31.7-1.2-1.2-1.31.31.31.31.21.21.2-1.31.3-1.01.01.00.90.91.21.2-1.2-1.11.0
Intermittent access intake escalation1.61.51.8-1.2-1.1-1.31.31.31.31.31.31.3-1.31.3-1.11.21.21.11.11.21.2-1.2-1.21.2
Intermittent access intake escalation 20.20.20.4-0.5-0.4-0.60.50.50.50.50.40.5-0.60.6-0.30.40.40.30.30.20.3-0.3-0.30.2
Intermitt. access day 1 inactive lever presses2.83.03.71.71.71.9-1.8-1.8-1.8-1.8-1.8-1.81.9-1.91.7-1.7-1.7-1.6-1.6-1.5-1.51.51.6-1.6
Intermitt. access day 15 inactive lever presses1.01.11.60.91.11.1-1.1-1.1-1.1-1.1-1.0-1.01.1-1.11.0-1.2-1.2-1.1-1.1-0.8-0.70.70.9-0.9
Intermitt. access escalation Index0.20.20.30.30.50.5-0.5-0.5-0.5-0.6-0.5-0.50.5-0.50.3-0.3-0.3-0.2-0.2-0.4-0.40.40.5-0.3
Intermittent access day 1 total infusions0.30.30.5-0.5-0.2-0.50.60.60.60.60.60.6-0.40.4-0.50.60.60.60.60.70.7-0.7-0.70.7
Intermittent access day 15 total infusions1.72.02.3-1.3-1.1-1.41.41.51.51.41.51.5-1.41.4-1.31.41.41.31.31.51.5-1.5-1.41.4
Intermittent access terminal intake (last 3 days)1.92.12.6-1.5-1.2-1.61.61.61.61.61.61.6-1.61.6-1.21.11.11.01.01.61.6-1.6-1.41.3
Intermittent access total infusions0.60.71.2-0.7-0.4-0.80.80.80.80.90.90.9-0.80.8-0.70.70.70.70.71.01.1-1.1-0.90.9
Intermittent access day 1 locomotion0.70.71.1-0.7-0.5-0.80.80.90.90.90.90.9-0.60.6-0.51.01.00.80.81.11.1-1.1-1.00.7
Intermittent access day 15 total locomotion0.20.20.5-0.3-0.0-0.40.50.50.50.50.50.5-0.20.2-0.30.60.60.50.50.60.6-0.6-0.70.5
Intermittent access total locomotion0.30.40.6-0.6-0.3-0.60.60.60.60.70.70.7-0.50.5-0.40.70.70.60.60.70.7-0.7-0.70.6
Intermittent access standard deviation3.43.64.2-1.7-1.6-2.02.02.02.02.02.02.0-2.02.0-1.71.81.81.71.71.91.9-1.9-1.91.7
Left kidney weight1.13.05.02.01.92.0-1.9-1.9-1.9-1.7-1.6-1.72.2-2.21.8-1.8-1.8-1.7-1.7-1.1-1.31.31.0-1.2
Right kidney weight0.61.73.51.71.51.5-1.5-1.5-1.5-1.2-1.2-1.21.9-1.91.3-1.2-1.2-1.2-1.2-0.7-0.80.80.5-0.7
Cocaine induced anxiety2.63.03.71.71.71.7-1.7-1.7-1.7-1.8-1.8-1.81.4-1.41.8-1.9-1.9-1.8-1.8-1.7-1.71.71.9-1.8
Post-drug Anxiety2.12.43.11.41.61.4-1.4-1.4-1.4-1.5-1.6-1.51.2-1.21.6-1.7-1.7-1.7-1.7-1.6-1.61.61.8-1.7
Baseline Anxiety1.61.72.2-1.5-1.3-1.41.31.31.41.31.31.3-1.41.4-1.31.31.31.31.31.11.1-1.1-1.21.3
Tail length3.610.814.03.63.73.4-3.4-3.4-3.4-3.2-3.2-3.33.6-3.63.4-3.2-3.2-3.2-3.2-3.0-3.03.02.8-3.0
Length with tail5.018.423.64.94.74.6-4.5-4.5-4.5-4.3-4.3-4.34.7-4.74.4-4.1-4.1-4.1-4.1-3.8-3.93.93.6-3.9
Length without tail2.45.26.62.52.22.5-2.5-2.5-2.5-2.4-2.3-2.32.6-2.62.3-2.1-2.1-2.1-2.1-2.0-2.22.21.9-1.9
Times rat made contact with spout0.20.30.50.50.40.4-0.4-0.5-0.4-0.5-0.5-0.50.2-0.20.7-0.3-0.3-0.4-0.5-0.7-0.70.70.7-0.7
Lifetime Intake0.30.30.6-0.3-0.0-0.50.50.50.50.60.60.6-0.50.5-0.30.50.50.50.40.70.8-0.8-0.60.5
Liver weight, left2.84.55.42.32.22.0-2.0-2.0-2.0-2.1-2.1-2.11.7-1.72.1-2.3-2.3-2.3-2.3-2.2-2.02.02.2-2.3
Liver weight, right0.00.00.2-0.20.10.1-0.1-0.1-0.1-0.1-0.1-0.10.0-0.00.0-0.4-0.4-0.4-0.4-0.10.1-0.10.1-0.0
Locomotor activity0.10.20.30.40.20.5-0.5-0.5-0.5-0.5-0.4-0.40.5-0.50.4-0.3-0.3-0.4-0.40.0-0.40.40.3-0.1
Locomotor testing distance0.30.50.70.80.60.9-0.9-0.8-0.8-0.8-0.8-0.80.7-0.70.8-0.7-0.7-0.7-0.7-0.4-0.70.70.7-0.5
Locomotor testing rearing1.42.13.1-1.8-1.6-1.41.41.41.41.41.41.4-1.71.7-1.41.21.21.21.21.61.4-1.4-1.21.6
Locomotion in novel chamber5.87.28.32.82.82.8-2.8-2.7-2.8-2.7-2.7-2.72.9-2.92.8-2.8-2.8-2.8-2.8-2.3-2.42.42.4-2.5
Locomotion in novel chamber post-restriction0.10.10.2-0.20.1-0.20.20.20.20.30.30.20.1-0.1-0.20.30.30.30.30.20.3-0.3-0.50.3
Fecal boli incidents, locomotor time 12.22.53.8-2.0-1.9-1.71.71.71.71.61.61.6-1.51.5-1.71.51.51.51.51.21.3-1.3-1.31.3
Change in fecal boli incidents, locomotor task1.21.13.92.01.81.2-1.1-1.1-1.1-0.8-0.8-0.81.7-1.71.2-0.7-0.7-0.7-0.6-0.1-0.30.30.1-0.3
Time >=10cm from walls, locomotor time 10.30.30.60.0-0.1-0.50.60.60.60.60.60.6-0.20.2-0.40.60.60.60.60.70.8-0.8-0.80.7
Bouts of movement, locomotor time 11.71.94.1-1.9-2.0-1.41.41.41.41.31.21.3-1.71.7-1.51.21.21.21.20.81.1-1.1-1.00.9
Total resting periods, locomotor time 11.61.83.6-1.8-1.9-1.41.41.31.31.31.21.3-1.71.7-1.51.11.11.11.10.81.1-1.1-1.01.0
Rest time, locomotor task time 10.20.20.7-0.2-0.10.1-0.1-0.1-0.1-0.3-0.3-0.3-0.30.30.1-0.8-0.8-0.8-0.8-0.5-0.50.50.6-0.5
Distance moved, locomotor task time 10.20.30.60.1-0.1-0.30.30.30.40.40.50.5-0.10.1-0.30.80.80.70.70.70.6-0.6-0.60.7
Vertical activity count, locomotor time 10.50.50.70.70.60.8-0.8-0.8-0.8-0.8-0.8-0.80.6-0.60.8-0.3-0.3-0.4-0.4-0.7-0.80.80.8-0.7
Time >=10cm from walls, locomotor time 20.60.61.00.60.40.7-0.7-0.7-0.7-0.8-0.8-0.80.5-0.50.7-1.0-1.0-1.0-1.0-0.9-0.70.70.9-0.9
Bouts of movement, locomotor time 21.82.02.61.21.21.4-1.4-1.4-1.4-1.4-1.5-1.51.3-1.31.4-1.4-1.4-1.4-1.4-1.6-1.41.41.4-1.6
Total resting periods, locomotor time 21.41.51.81.11.11.2-1.2-1.2-1.2-1.2-1.3-1.31.1-1.11.3-1.2-1.2-1.2-1.2-1.3-1.21.21.2-1.3
Rest time, locomotor task time 20.20.20.50.50.70.4-0.4-0.4-0.4-0.5-0.5-0.50.3-0.30.5-0.6-0.6-0.6-0.6-0.4-0.40.40.6-0.5
Distance moved, locomotor task time 20.20.20.5-0.5-0.7-0.40.40.40.40.40.40.4-0.50.5-0.50.60.60.50.50.50.4-0.4-0.40.5
Vertical activity count, locomotor time 20.40.40.80.1-0.10.5-0.6-0.6-0.6-0.7-0.7-0.70.3-0.30.5-0.6-0.6-0.7-0.7-0.8-0.80.80.9-0.8
Light reinforcement 10.00.00.10.30.10.0-0.0-0.0-0.00.00.00.00.1-0.10.10.20.20.20.20.10.0-0.0-0.10.2
Light reinforcement 21.82.53.0-1.4-1.5-1.71.71.71.71.61.61.6-1.61.6-1.51.71.71.71.71.31.4-1.4-1.41.3
Bone: marrow area0.10.30.5-0.4-0.5-0.40.40.40.40.50.50.5-0.10.1-0.40.70.70.70.70.60.7-0.7-0.70.4
Bone: maximum diameter0.10.10.5-0.20.1-0.30.30.20.20.0-0.00.0-0.70.7-0.0-0.1-0.1-0.1-0.1-0.4-0.20.20.5-0.4
Bone: maximum force0.20.40.70.50.60.6-0.6-0.6-0.6-0.6-0.7-0.70.5-0.50.7-0.6-0.6-0.6-0.6-0.8-0.60.60.7-0.9
Bone: maximum moment0.20.30.70.50.60.6-0.5-0.6-0.6-0.6-0.6-0.60.5-0.50.6-0.5-0.5-0.5-0.5-0.8-0.50.50.6-0.8
Mean time between licks in bursts0.70.91.6-0.7-0.7-0.91.01.01.01.11.11.0-0.60.6-0.71.01.00.90.91.21.2-1.2-1.21.0
Mean num. licks in bursts0.00.00.10.20.20.2-0.2-0.2-0.2-0.2-0.1-0.20.3-0.30.30.30.30.20.2-0.1-0.20.20.1-0.1
Cd content in liver0.91.03.11.01.01.2-1.2-1.1-1.2-0.9-0.9-0.91.8-1.81.4-0.6-0.6-0.8-0.8-0.5-0.40.40.3-1.0
Co content in liver1.11.31.91.11.21.2-1.2-1.2-1.2-1.1-1.1-1.11.4-1.41.1-1.0-1.0-1.0-1.0-1.1-1.01.00.9-1.0
Cu content in liver1.21.52.3-1.0-1.1-1.41.41.41.41.31.31.3-1.51.5-1.11.11.11.01.01.31.1-1.1-1.01.0
Fe content in liver0.20.30.6-0.5-0.7-0.60.50.50.50.50.50.5-0.80.8-0.70.50.50.50.50.50.3-0.3-0.30.3
K content in liver0.10.10.30.40.40.3-0.3-0.3-0.3-0.3-0.3-0.30.2-0.20.3-0.2-0.2-0.3-0.3-0.4-0.60.60.4-0.3
Mg content in liver0.20.20.50.70.70.4-0.4-0.4-0.4-0.4-0.3-0.40.4-0.40.4-0.2-0.2-0.2-0.2-0.4-0.60.60.3-0.1
Mn content in liver0.20.20.70.60.60.5-0.5-0.5-0.5-0.4-0.3-0.40.9-0.90.20.00.00.10.2-0.2-0.30.3-0.10.2
Na content in liver0.20.20.7-0.3-0.5-0.50.50.40.50.30.30.3-0.90.9-0.50.10.10.20.20.20.0-0.00.10.3
Rb content in liver0.81.01.41.21.11.2-1.2-1.1-1.1-1.1-1.0-1.11.2-1.20.8-0.8-0.8-0.7-0.6-1.0-1.11.10.8-0.6
Se content in liver0.10.10.3-0.1-0.3-0.30.30.30.30.40.30.3-0.30.30.00.60.60.30.30.20.4-0.4-0.4-0.1
Sr content in liver0.30.30.80.60.60.6-0.6-0.6-0.6-0.5-0.6-0.60.7-0.70.8-0.3-0.3-0.5-0.5-0.4-0.30.30.4-0.9
Zn content in liver0.20.20.50.60.60.3-0.3-0.4-0.4-0.4-0.4-0.40.2-0.20.6-0.2-0.2-0.3-0.4-0.7-0.40.40.5-0.6
Bone: minimum diameter0.71.42.01.31.41.2-1.2-1.2-1.2-1.2-1.2-1.21.3-1.31.3-1.0-1.0-1.1-1.1-1.1-1.11.11.0-1.1
Time in familiar zone, hab. session 10.30.30.6-0.7-0.6-0.30.30.30.30.40.50.5-0.00.0-0.40.50.50.50.50.80.6-0.6-0.70.7
Time in novel zone, hab. session 10.20.20.4-0.3-0.4-0.60.50.50.50.50.40.4-0.70.7-0.50.40.40.40.40.20.3-0.3-0.20.1
Total zone transitions, hab. session 10.50.61.1-0.7-0.7-0.60.60.60.60.80.70.7-0.20.2-0.81.11.11.01.01.00.9-0.9-1.00.8
Total locomotion distance, hab. session 10.10.20.90.50.50.6-0.6-0.5-0.6-0.4-0.4-0.40.9-0.90.5-0.0-0.0-0.0-0.00.0-0.10.1-0.1-0.1
Locomotion velocity, hab. session 10.60.81.61.11.11.1-1.1-1.0-1.0-0.9-0.9-0.91.2-1.21.0-0.7-0.7-0.7-0.7-0.6-0.70.70.6-0.7
Time in familiar zone, hab. session 20.40.40.8-0.7-0.6-0.40.40.50.50.50.60.6-0.40.4-0.50.60.60.60.60.90.7-0.7-0.80.8
Time in novel zone, hab. session 20.10.10.1-0.0-0.1-0.30.30.30.30.30.30.3-0.30.3-0.30.20.20.20.30.10.2-0.2-0.20.1
Total zone transitions, hab. session 20.81.01.4-1.0-1.0-1.01.01.01.01.01.01.0-1.01.0-1.11.21.21.21.20.90.9-0.9-0.90.8
Total locomotion distance, hab. session 20.30.40.60.60.60.6-0.6-0.6-0.6-0.6-0.7-0.70.5-0.50.6-0.5-0.5-0.5-0.5-0.6-0.70.70.7-0.7
Locomotion velocity, hab. session 20.40.60.90.80.80.8-0.8-0.8-0.8-0.8-0.8-0.80.6-0.60.8-0.7-0.7-0.7-0.7-0.8-0.90.90.9-0.9
Novel to familiar place preference ratio0.50.50.9-1.0-0.9-0.80.80.80.80.70.70.7-0.80.8-0.80.60.60.60.60.50.6-0.6-0.60.6
Novelty place preference0.30.30.6-0.8-0.7-0.60.60.60.60.60.50.5-0.60.6-0.60.40.40.50.50.40.5-0.5-0.40.4
Time in novel zone, NPP test0.20.20.5-0.7-0.7-0.50.50.50.50.50.50.5-0.50.5-0.50.40.40.40.40.30.4-0.4-0.40.4
Total zone transitions, NPP test0.10.10.4-0.3-0.3-0.10.10.10.10.30.20.20.3-0.3-0.30.60.60.60.60.30.4-0.4-0.60.4
Total locomotion distance, NPP test0.10.10.40.20.20.4-0.4-0.3-0.4-0.2-0.2-0.30.6-0.60.20.00.00.00.0-0.2-0.10.1-0.0-0.1
Locomotion velocity, NPP test0.10.10.40.30.30.4-0.4-0.4-0.4-0.3-0.3-0.30.6-0.60.3-0.1-0.1-0.1-0.1-0.3-0.20.20.1-0.2
Intraocular pressure0.10.10.2-0.4-0.5-0.20.20.20.20.20.20.2-0.10.1-0.40.30.30.30.30.30.3-0.3-0.30.3
Delta distance traveled before/after self-admin0.10.10.40.60.00.5-0.4-0.4-0.4-0.3-0.3-0.30.6-0.60.5-0.0-0.0-0.1-0.1-0.2-0.30.3-0.0-0.4
Delta ambulatory time before/after self-admin0.80.91.61.30.71.1-1.1-1.1-1.1-0.9-0.9-1.01.2-1.21.1-0.6-0.6-0.7-0.7-0.9-0.90.90.5-0.9
Parametrial fat weight0.00.00.0-0.2-0.2-0.20.20.20.20.10.10.1-0.20.2-0.20.20.20.20.2-0.10.0-0.0-0.0-0.0
Pavlov. Cond. lever latency0.81.01.11.01.01.0-1.0-1.0-1.0-1.0-1.0-1.01.0-1.01.0-1.0-1.0-1.0-1.0-0.8-1.01.00.9-1.0
Pavlov. Cond. magazine entry latency0.50.71.5-1.1-1.2-0.80.80.80.80.80.80.8-0.80.8-0.90.80.80.80.80.50.8-0.8-0.70.7
Pavlov. Cond. change in total contacts0.30.30.5-0.7-0.6-0.60.50.50.60.50.50.5-0.60.6-0.50.50.50.50.50.40.5-0.5-0.50.6
Pavlov. Cond. index score1.11.32.0-1.4-1.4-1.21.21.21.21.11.11.1-1.21.2-1.21.11.11.11.10.81.2-1.2-1.01.0
Pavlov. Cond. latency score0.70.91.4-1.2-1.2-1.01.01.01.00.90.90.9-1.01.0-1.00.90.90.90.90.60.9-0.9-0.80.8
Pavlov. Cond. lever contacts1.11.21.7-1.3-1.2-1.21.21.21.21.11.11.1-1.31.3-1.21.01.01.01.00.81.0-1.0-0.91.0
Pavlov. Cond. magazine entry number1.01.31.71.21.31.1-1.1-1.1-1.1-1.1-1.1-1.11.0-1.01.2-1.2-1.2-1.2-1.2-1.0-1.21.21.2-1.1
Pavlov. Cond. intertrial magazine entries5.97.18.22.92.92.7-2.7-2.7-2.7-2.7-2.7-2.72.7-2.72.8-2.6-2.6-2.6-2.6-2.3-2.62.62.5-2.6
Pavlov. Cond. lever-magazine prob. diff.0.81.01.6-1.2-1.3-1.01.01.01.01.01.01.0-1.11.1-1.10.90.90.90.90.61.0-1.0-0.80.8
Pavlov. Cond. response bias1.21.51.8-1.3-1.3-1.21.21.21.21.21.21.2-1.11.1-1.31.21.21.21.20.91.3-1.3-1.21.2
Pavlov. Cond. lever latency1.82.43.41.31.31.5-1.5-1.6-1.6-1.7-1.7-1.61.2-1.21.2-1.7-1.7-1.6-1.6-1.7-1.81.81.8-1.5
Pavlov. Cond. magazine entry latency4.65.36.3-2.1-2.1-2.32.32.32.32.42.42.4-2.12.1-2.02.42.42.22.22.52.4-2.4-2.52.2
Pavlov. Cond. change in total contacts3.75.16.4-2.3-2.2-2.32.32.32.32.42.42.4-2.22.2-2.02.02.02.02.02.52.4-2.4-2.42.3
Pavlov. Cond. index score4.45.77.3-2.1-2.1-2.32.32.42.42.52.52.5-2.02.0-2.02.52.52.42.42.72.6-2.6-2.72.4
Pavlov. Cond. latency score4.45.56.7-2.1-2.1-2.32.32.32.32.42.42.4-2.02.0-2.12.52.52.42.42.62.5-2.5-2.62.4
Pavlov. Cond. lever contacts2.53.54.6-1.6-1.6-1.91.91.91.92.02.02.0-1.61.6-1.51.91.91.81.82.12.1-2.1-2.11.7
Pavlov. Cond. magazine entry number3.54.35.61.81.82.0-2.0-2.1-2.1-2.1-2.2-2.11.8-1.81.9-2.1-2.1-2.0-2.0-2.4-2.22.22.3-2.2
Pavlov. Cond. intertrial magazine entries5.87.58.02.82.72.7-2.7-2.7-2.7-2.8-2.7-2.72.6-2.62.8-2.8-2.8-2.8-2.8-2.7-2.82.82.7-2.7
Pavlov. Cond. lever-magazine prob. diff.4.96.38.0-2.2-2.2-2.42.52.52.52.62.62.6-2.12.1-2.22.62.62.52.52.82.7-2.7-2.82.6
Pavlov. Cond. response bias3.24.46.2-1.8-1.8-2.12.12.12.12.32.32.2-1.71.7-1.72.12.12.02.02.42.4-2.4-2.52.1
Time in closed arm before self-admin3.43.85.0-2.1-2.2-2.12.02.02.02.02.02.0-2.22.2-1.71.91.91.71.71.82.0-2.0-1.81.6
Time in closed arm after self-admin1.51.52.4-1.2-1.5-1.21.21.21.21.31.31.3-1.01.0-1.01.11.11.01.01.31.5-1.5-1.41.2
Time in open arm before self-admin5.76.29.12.83.02.6-2.6-2.6-2.6-2.5-2.5-2.52.8-2.82.1-2.5-2.5-2.2-2.2-2.3-2.42.42.3-1.9
Time in open arm after self-admin3.64.05.72.12.42.0-2.0-2.0-2.0-2.0-2.0-2.02.0-2.02.1-1.9-1.9-1.9-1.9-1.8-1.81.81.8-1.9
Bone: periosteal estimation0.10.10.40.30.40.3-0.2-0.3-0.3-0.3-0.4-0.40.2-0.20.4-0.3-0.3-0.3-0.3-0.5-0.30.30.4-0.6
Bone: periosteal perimeter0.00.00.20.20.4-0.00.00.0-0.0-0.1-0.1-0.1-0.20.20.2-0.2-0.2-0.1-0.1-0.3-0.10.10.3-0.4
Bone: post-yield work1.42.03.21.21.21.6-1.6-1.6-1.6-1.4-1.4-1.41.8-1.81.5-1.3-1.3-1.3-1.3-1.0-1.31.31.1-1.2
Progressive ratio test 1 active lever presses0.00.00.0-0.10.1-0.10.10.10.10.10.10.1-0.10.10.1-0.1-0.1-0.1-0.10.20.1-0.1-0.10.0
Progressive ratio test 1 breakpoint0.10.10.1-0.3-0.1-0.30.30.30.30.30.30.3-0.40.4-0.00.10.1-0.0-0.00.30.3-0.3-0.30.2
Progressive ratio test 1 inactive lever presses2.83.13.41.71.71.8-1.8-1.8-1.8-1.8-1.8-1.81.7-1.71.7-1.8-1.8-1.8-1.8-1.7-1.61.61.7-1.7
Progressive ratio test 2 active lever presses0.00.00.10.00.3-0.10.10.10.10.10.10.1-0.00.0-0.2-0.1-0.10.00.00.20.2-0.2-0.10.3
Progressive ratio test 2 breakpoint0.00.00.20.20.40.1-0.0-0.0-0.0-0.00.00.00.1-0.1-0.1-0.1-0.1-0.00.00.20.2-0.2-0.10.2
Progressive ratio test 2 inactive lever presses0.91.01.40.91.21.0-1.0-1.0-1.0-1.0-1.0-1.01.0-1.01.0-1.2-1.2-1.1-1.1-0.9-0.80.81.0-0.9
Incentive Sensitization - Responses0.00.00.20.10.2-0.00.00.00.00.10.10.10.0-0.0-0.3-0.0-0.00.20.20.20.2-0.2-0.10.4
Incentive Sensitization - Breakpoint0.00.00.10.20.30.1-0.1-0.1-0.1-0.1-0.0-0.00.2-0.2-0.2-0.1-0.10.10.10.10.1-0.1-0.00.3
Sum of active levers in priming session hrs 5-60.40.40.8-0.5-0.2-0.70.70.70.70.60.60.6-0.90.9-0.50.70.70.70.70.40.3-0.3-0.20.4
Progressive ratio0.40.51.31.01.10.6-0.6-0.6-0.6-0.7-0.7-0.70.7-0.70.9-0.4-0.4-0.5-0.5-0.7-0.80.80.7-0.7
Food seeking constrained by brief footshock1.31.62.70.50.81.1-1.1-1.2-1.2-1.3-1.3-1.30.7-0.71.2-1.4-1.4-1.4-1.4-1.3-1.51.51.6-1.6
Seeking ratio, punishment vs. effort0.10.10.2-0.4-0.40.2-0.2-0.2-0.2-0.3-0.3-0.3-0.10.10.0-0.5-0.5-0.4-0.4-0.2-0.20.20.3-0.4
Retroperitoneal fat weight0.20.81.0-0.9-0.9-0.90.90.90.90.90.90.9-1.01.0-1.00.80.80.80.80.80.7-0.7-0.80.9
Reaction time number correct3.55.06.22.42.22.2-2.2-2.2-2.2-2.2-2.2-2.22.2-2.22.2-2.5-2.5-2.4-2.4-2.1-2.12.12.1-2.0
Reaction time mean minus median0.20.20.8-0.9-0.8-0.40.40.40.40.40.40.4-0.30.3-0.50.20.20.30.30.40.5-0.5-0.50.4
Reaction time mean minus median AUC0.10.10.5-0.7-0.6-0.30.30.30.30.40.40.3-0.10.1-0.40.20.20.20.20.40.5-0.5-0.50.3
Reaction time num false alarms1.01.32.21.51.41.2-1.2-1.2-1.1-1.2-1.1-1.11.1-1.11.2-1.2-1.2-1.2-1.2-1.0-1.11.11.1-0.9
Reaction time num false alarms AUC1.52.03.01.71.61.4-1.4-1.4-1.4-1.4-1.4-1.41.3-1.31.5-1.4-1.4-1.5-1.5-1.4-1.31.31.4-1.2
Reaction time trials correct on left3.55.06.22.42.22.2-2.2-2.2-2.2-2.2-2.2-2.22.2-2.22.2-2.5-2.5-2.4-2.4-2.1-2.12.12.1-2.0
Reaction time trials on left3.55.06.22.42.22.2-2.2-2.2-2.2-2.2-2.2-2.22.2-2.22.2-2.5-2.5-2.4-2.4-2.0-2.02.02.1-2.0
Reaction time mean0.91.22.5-1.6-1.3-1.11.11.11.11.11.11.1-0.90.9-1.21.01.01.01.01.11.0-1.0-1.31.1
Reaction time mean AUC0.60.81.7-1.3-1.1-0.80.80.80.80.90.90.9-0.60.6-0.90.80.80.80.80.90.8-0.8-1.10.9
Median of all reaction times0.50.71.3-1.1-0.9-0.70.70.70.70.80.80.8-0.60.6-0.80.80.80.80.80.90.7-0.7-1.00.9
Reaction time omissions1.01.32.00.70.61.2-1.2-1.2-1.2-1.1-1.1-1.21.2-1.21.0-1.4-1.4-1.3-1.3-1.1-1.11.10.9-1.1
Reaction time false alarm rate0.10.10.30.50.50.3-0.3-0.3-0.3-0.3-0.3-0.30.2-0.20.4-0.3-0.3-0.3-0.3-0.3-0.30.30.3-0.2
Reaction time premature initiation rate0.81.11.40.91.21.0-1.0-1.0-1.0-1.0-1.1-1.11.1-1.11.2-1.0-1.0-1.1-1.1-1.1-1.01.01.1-1.1
Reaction time premature initiations2.84.04.41.92.11.9-2.0-2.0-2.0-2.0-2.0-2.02.0-2.02.1-2.1-2.1-2.1-2.1-2.0-1.91.91.9-1.9
Std. dev. reaction times0.40.61.6-1.3-1.1-0.70.70.70.70.80.80.7-0.60.6-0.80.50.50.60.60.70.8-0.8-0.90.6
Reaction time trials completed3.55.06.22.42.22.2-2.2-2.2-2.2-2.2-2.2-2.22.2-2.22.2-2.5-2.5-2.4-2.4-2.0-2.02.02.1-2.0
Reaction time trials AUC3.85.46.72.52.32.3-2.3-2.3-2.3-2.3-2.3-2.32.3-2.32.3-2.6-2.6-2.6-2.6-2.1-2.12.12.2-2.1
Run reversals in cocaine runway, females1.31.22.9-1.2-1.7-1.11.11.11.11.11.11.1-1.11.1-1.10.90.90.90.91.11.0-1.0-1.01.1
Run reversals in cocaine runway, males0.80.71.40.20.60.7-0.7-0.7-0.7-0.8-0.9-0.80.4-0.40.8-1.0-1.0-1.0-1.0-1.2-1.11.11.1-1.0
Latency to leave start box in cocaine runway0.10.10.4-0.2-0.2-0.50.40.40.40.40.40.4-0.60.6-0.20.20.20.20.20.20.3-0.3-0.20.5
Latency to leave start box in cocaine runway, F0.20.20.7-0.6-0.5-0.60.50.50.50.40.40.4-0.80.8-0.40.10.10.10.10.20.2-0.2-0.10.5
Latency to leave start box in cocaine runway, M0.10.10.3-0.2-0.1-0.50.50.40.50.40.40.4-0.50.5-0.30.40.40.30.30.10.3-0.3-0.20.4
Std. dev. time between licks in bursts0.40.51.3-0.6-0.4-0.40.50.50.50.70.70.70.0-0.0-0.60.70.70.70.80.90.9-0.9-1.20.8
Total sessions with >9 infusions0.00.00.10.10.3-0.10.10.10.10.10.10.1-0.00.00.20.30.30.10.10.20.2-0.2-0.20.0
Short access day 1 total inactive lever presses0.00.10.20.20.30.1-0.1-0.1-0.10.00.10.10.4-0.4-0.00.00.00.10.10.30.3-0.3-0.30.3
Short access day 10 total inactive lever presses0.50.51.00.70.70.9-0.9-0.9-0.9-0.8-0.8-0.81.0-1.00.4-0.7-0.7-0.6-0.5-0.5-0.50.50.5-0.4
Short access day 1 total infusions0.40.41.00.81.00.6-0.6-0.6-0.6-0.6-0.5-0.50.7-0.70.9-0.5-0.5-0.6-0.6-0.5-0.50.50.5-0.6
Short access day 10 total infusions0.30.30.7-0.3-0.1-0.60.60.60.60.60.60.6-0.50.5-0.30.50.50.40.40.80.8-0.8-0.70.6
Short access total infusions0.10.20.3-0.10.2-0.40.40.40.40.40.40.4-0.30.30.10.40.40.30.30.50.6-0.6-0.50.2
Short access day 1 locomotion0.40.40.9-0.4-0.3-0.60.70.70.70.70.80.8-0.50.5-0.20.70.70.50.50.90.9-0.9-0.90.6
Short access day 10 total locomotion0.50.60.8-0.9-0.6-0.80.80.80.80.80.80.8-0.80.8-0.40.80.80.60.60.90.9-0.9-0.80.6
Short access total locomotion0.00.00.1-0.10.1-0.20.20.20.20.20.20.2-0.20.20.30.30.30.10.00.30.3-0.3-0.3-0.0
One hour access (0.3 mA shock)0.10.10.50.40.70.3-0.3-0.3-0.3-0.3-0.3-0.30.3-0.30.5-0.5-0.5-0.5-0.5-0.1-0.00.00.3-0.3
Compulsive drug intake0.00.00.1-0.0-0.3-0.00.00.00.00.10.10.10.2-0.2-0.10.20.20.20.20.20.2-0.2-0.20.2
One hour access (shock baseline)0.00.00.10.00.3-0.20.20.20.20.10.10.2-0.20.20.10.10.10.00.00.20.2-0.2-0.10.0
Social response proportion0.40.51.01.01.00.7-0.7-0.7-0.7-0.6-0.6-0.60.6-0.60.7-0.7-0.7-0.7-0.7-0.5-0.50.50.5-0.5
Social responses0.10.10.2-0.1-0.1-0.10.10.10.10.20.20.2-0.20.2-0.10.50.50.40.40.20.2-0.2-0.20.3
Social time1.31.73.01.51.41.4-1.4-1.4-1.4-1.2-1.2-1.21.7-1.71.3-1.2-1.2-1.2-1.2-1.2-1.01.00.8-1.1
Soleus weight0.00.00.20.30.20.2-0.2-0.2-0.2-0.0-0.0-0.00.5-0.50.10.10.10.10.10.00.2-0.2-0.40.3
Bone: stiffness1.42.32.91.51.61.5-1.5-1.5-1.5-1.5-1.6-1.61.5-1.51.6-1.4-1.4-1.4-1.4-1.6-1.51.51.5-1.7
Tibialis anterior weight0.41.21.61.11.21.1-1.1-1.1-1.1-1.1-1.1-1.11.0-1.01.1-1.3-1.3-1.2-1.2-1.1-0.90.91.0-1.0
Time to tail flick, vehicle, before self-admin0.40.40.60.70.60.7-0.7-0.7-0.7-0.7-0.8-0.70.7-0.7-0.0-0.6-0.6-0.3-0.2-0.7-0.70.70.7-0.2
Time to tail flick, vehicle, after self-admin0.10.10.30.2-0.4-0.10.20.20.20.30.30.30.2-0.2-0.00.20.20.10.10.40.4-0.4-0.50.2
Time to tail flick, test, before self-admin0.10.10.10.10.30.2-0.2-0.2-0.2-0.3-0.3-0.3-0.10.1-0.0-0.3-0.3-0.2-0.2-0.3-0.20.20.3-0.1
Time to tail flick, test, after self-admin1.71.82.21.51.01.4-1.4-1.4-1.4-1.4-1.4-1.41.4-1.41.1-1.4-1.4-1.3-1.2-1.3-1.41.41.3-1.2
Delta time to tail flick, vehicle, before/after SA0.00.00.2-0.0-0.3-0.10.10.10.10.20.20.20.1-0.10.40.00.0-0.2-0.20.30.2-0.2-0.3-0.2
Delta time to tail flick, test, before/after SA1.21.11.91.40.71.1-1.1-1.1-1.1-1.0-1.0-1.01.3-1.31.2-0.8-0.8-0.9-0.9-0.9-1.01.00.8-1.0
Tibia length0.30.81.90.70.80.6-0.7-0.7-0.7-0.8-0.9-0.90.3-0.30.7-1.0-1.0-1.0-1.0-1.4-1.01.01.2-1.3
Ambulatory time before self-admin0.30.31.0-1.0-0.4-0.70.60.60.60.50.50.5-0.90.9-0.4-0.1-0.1-0.1-0.10.40.4-0.4-0.00.2
Ambulatory time after self-admin0.00.00.0-0.2-0.1-0.10.10.10.10.10.10.1-0.20.2-0.00.00.0-0.0-0.00.10.2-0.2-0.10.0
Bone: tissue strength0.00.00.2-0.1-0.2-0.0-0.0-0.0-0.0-0.1-0.2-0.1-0.20.20.0-0.1-0.1-0.1-0.1-0.3-0.20.20.4-0.4
Total heroin consumption0.80.91.70.71.20.8-0.8-0.8-0.8-1.0-1.0-1.00.6-0.60.8-0.8-0.8-0.8-0.8-1.2-1.31.31.3-1.0
Bone: trabecular number0.10.10.40.20.20.4-0.4-0.4-0.4-0.3-0.3-0.30.6-0.60.3-0.2-0.2-0.2-0.2-0.1-0.30.30.1-0.1
Bone: trabecular spacing0.10.10.1-0.1-0.1-0.40.40.40.40.30.30.3-0.30.3-0.30.20.20.20.20.20.3-0.3-0.20.2
Bone: trabecular thickness0.10.10.20.20.30.3-0.3-0.3-0.3-0.3-0.3-0.30.2-0.20.3-0.2-0.2-0.3-0.3-0.4-0.40.40.4-0.4
Bone: trabecular tissue density0.20.20.60.10.40.3-0.3-0.3-0.3-0.5-0.4-0.4-0.20.20.3-0.6-0.6-0.7-0.7-0.4-0.70.70.8-0.4
Water consumed over 24 hours2.93.54.62.02.01.9-1.9-1.9-1.9-2.0-2.0-2.01.7-1.72.0-1.4-1.4-1.5-1.5-2.1-2.12.12.0-1.9
Number of responses in last shaping day0.40.40.6-0.5-0.5-0.70.70.70.70.70.70.7-0.70.7-0.60.70.70.70.70.50.5-0.5-0.70.5