Hub : Genes

Ppard

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Ppard 0.07 0.04 3.3e-06 0.06 0.05 0.04 0.05 4.5e-06 8.3e-06 1.8e-04 8.4e-06
2 OFC gene expression Ppard 0.19 0.1 1.3e-04 0.22 0.21 0.16 0.21 7.1e-06 1.1e-05 1.1e-04 1.2e-05
3 BLA alternative TSS NM_013141.2 0.15 0.09 3.2e-03 0 0.01 0.02 0.01 2.2e-01 1.5e-01 3.5e-02 8.2e-02
4 Adipose alternative TSS XM_006256167.5 0.04 0.03 1.5e-03 0.02 0.02 0.01 0.02 2.2e-03 9.0e-04 1.1e-02 1.1e-03
5 NAcc gene expression Ppard 0.13 0.06 2.6e-15 0.09 0.1 0.1 0.1 3.6e-13 3.5e-15 2.3e-15 1.1e-14
6 pVTA gene expression Ppard 0.09 0.06 1.2e-05 0.07 0.06 0.06 0.07 2.4e-06 1.2e-05 1.6e-05 2.4e-06
7 IC gene expression Ppard 0.63 0.18 1.6e-09 0.22 0.17 0.22 0.22 7.9e-10 1.7e-07 8.1e-10 7.5e-10
8 Adipose mRNA stability Ppard 0.04 0.03 6.3e-04 0.02 0.02 0.01 0.02 2.0e-03 2.2e-03 8.3e-03 4.0e-03
9 BLA gene expression Ppard 0.27 0.12 3.4e-10 0.22 0.16 0.18 0.2 1.1e-11 5.8e-09 9.6e-10 1.1e-10
10 PL gene expression Ppard 0.17 0.07 0.0e+00 0.14 0.15 0.16 0.16 9.6e-15 5.0e-16 7.9e-17 6.2e-17
11 Adipose gene expression Ppard 0.13 0.06 0.0e+00 0.2 0.19 0.19 0.19 3.2e-21 7.3e-21 3.3e-20 1.2e-20
12 pVTA mRNA stability Ppard 0.06 0.04 6.3e-03 0.01 0.02 0 0.01 8.5e-02 6.1e-03 2.0e-01 1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.10.6-0.1-0.10.4-0.80.30.30.00.50.20.1-0.1-0.4
Area under the delay curve0.40.51.60.1-0.3-1.30.6-0.7-0.5-0.6-0.3-0.5-0.5-0.9-1.0
BMI with tail1.24.111.6-3.4-3.20.11.6-1.7-2.0-1.7-2.0-1.8-1.9-1.8-0.8
BMI without tail0.92.86.3-2.4-2.2-0.71.8-1.7-1.7-1.3-2.5-1.2-1.4-1.5-0.5
Body weight3.013.223.5-2.3-2.6-3.54.8-4.3-4.0-3.6-4.4-3.5-3.7-3.7-1.9
Weight adjusted by age0.91.35.90.4-0.2-2.40.7-1.5-0.4-0.90.1-0.8-1.0-1.1-1.7
Bone surface0.10.31.00.50.7-1.00.4-0.4-0.4-0.5-0.5-0.3-0.2-0.50.1
Bone volume0.10.31.10.00.0-1.00.4-0.7-0.4-0.5-0.6-0.3-0.3-0.5-0.3
Breakpoint value in progressive ratio session0.50.61.8-1.4-1.01.30.20.2-0.5-0.8-0.0-0.8-0.8-0.60.4
Number of licking bursts0.61.02.11.01.20.1-0.41.10.81.10.61.11.21.11.5
Context. condit. distance diff. score0.81.03.91.92.0-0.3-0.20.60.60.70.70.70.70.50.9
Locomotion velocity, session 11.71.94.32.11.9-0.4-1.01.11.51.61.21.51.41.20.1
Locomotion distance, session 13.34.26.01.61.81.3-2.42.32.42.41.92.32.02.31.0
Locomotion velocity, session 20.60.71.71.11.3-0.0-0.21.00.50.60.90.60.90.41.1
Locomotion distance, session 20.91.22.31.21.10.7-1.31.51.31.11.21.10.91.20.3
Locomotion velocity, session 30.70.81.60.70.9-1.00.2-0.30.41.0-0.51.11.31.01.2
Locomotion distance, session 31.61.73.51.21.30.6-0.90.81.21.90.11.91.81.61.1
Stereotopy head waving bouts, day 31.11.34.70.30.4-2.21.9-1.3-1.2-0.9-1.2-0.8-0.5-0.90.4
Stereotopy head waving duration, day 30.40.53.40.70.6-1.80.6-0.6-0.3-0.40.3-0.40.0-0.4-0.1
Locomotion velocity, session 70.50.51.11.10.8-0.6-0.70.40.90.60.90.60.30.6-0.8
Locomotion distance, session 71.21.52.81.71.40.3-1.41.21.51.11.51.20.81.1-0.7
Stereotopy head waving bouts, day 70.50.61.90.30.3-1.20.9-1.1-0.20.4-1.40.50.90.30.7
Stereotopy head waving duration, day 70.40.41.6-0.1-0.1-0.91.0-1.0-0.40.2-1.30.20.50.10.6
Locomotion velocity, session 80.81.04.62.12.1-1.40.50.40.10.10.20.30.40.00.7
Locomotion distance, session 81.31.95.52.22.30.0-0.91.41.21.21.01.31.21.11.1
Degree of sensitization distance1.11.12.7-0.1-0.2-1.10.5-0.2-0.7-1.60.8-1.5-1.6-1.5-1.2
Degree of sensitization stereotypy0.60.62.00.40.50.2-0.3-0.10.61.1-0.41.21.40.90.9
Conditioned locomotion2.93.35.4-1.2-1.3-1.12.3-2.0-2.3-2.2-1.9-2.1-1.9-2.1-0.4
Cocaine response after cond. corrected0.50.61.1-1.0-0.8-0.90.8-0.9-0.9-0.7-1.0-0.7-0.6-0.80.5
Cocaine response after cond. not corrected0.50.61.8-0.3-0.1-1.30.9-0.9-0.8-0.6-1.1-0.6-0.3-0.70.7
Cocaine response before conditioning0.30.41.91.41.3-1.00.4-0.10.20.10.00.10.3-0.10.1
Saline control response2.12.75.6-2.3-2.4-0.50.7-1.7-1.5-1.9-0.7-1.9-1.8-1.9-1.3
Bone: connectivity density0.10.20.70.0-0.00.3-0.50.30.1-0.40.8-0.2-0.3-0.5-0.6
Bone: cortical apparent density0.30.51.8-1.3-1.20.8-0.1-0.5-0.6-0.3-0.8-0.3-0.4-0.40.2
Bone: cortical area0.10.10.30.20.2-0.4-0.10.30.40.50.20.50.20.50.1
Bone: cortical porosity0.80.91.91.41.0-0.6-0.50.31.01.00.71.11.01.2-0.6
Bone: cortical porosity1.01.12.61.61.0-1.4-0.50.21.00.91.10.80.71.0-1.3
Bone: cortical thickness1.01.63.1-0.6-0.51.8-1.81.21.41.50.91.61.11.50.3
Bone: cortical thickness0.60.73.6-1.9-1.70.8-0.50.1-0.2-0.50.3-0.3-0.5-0.2-0.2
Bone: cortical tissue density0.30.51.5-1.2-1.10.60.1-0.6-0.7-0.4-0.9-0.4-0.4-0.50.2
Condit. Reinf. active minus inactive responses0.40.41.70.70.4-0.4-0.80.20.5-0.01.2-0.0-0.20.1-1.3
Condit. Reinf. active-inactive response ratio0.50.50.9-0.8-0.90.20.1-0.5-0.6-0.90.0-0.9-0.9-0.9-0.8
Condit. Reinf. active responses0.30.42.30.2-0.2-0.0-0.4-0.20.1-0.40.7-0.5-0.8-0.3-1.5
Condit. Reinf. inactive responses0.20.20.7-0.0-0.30.6-0.60.30.40.10.80.0-0.20.1-0.9
Incentive salience index mean0.30.41.31.10.9-0.4-0.50.40.60.30.90.30.00.3-0.8
Condit. Reinf. lever presses0.20.31.21.11.1-0.1-0.00.70.50.60.50.40.20.3-0.0
Condit. Reinf. active minus inactive responses0.30.31.31.11.00.5-0.40.70.50.20.70.10.10.3-0.3
Condit. Reinf. active-inactive response ratio0.10.10.60.80.7-0.00.00.20.10.00.1-0.2-0.10.1-0.2
Condit. Reinf. active responses0.40.51.21.01.00.6-0.61.00.70.41.10.30.30.4-0.2
Condit. Reinf. inactive responses0.00.00.1-0.00.0-0.00.00.20.1-0.20.30.0-0.0-0.30.0
Condit. Reinf. lever presses2.12.96.71.51.22.5-2.12.21.81.22.61.11.01.2-0.5
Condit. Reinf. lever reinforcers received0.81.12.51.41.30.9-1.01.41.20.81.60.70.60.8-0.1
Conditioned reinforcement - actives0.10.10.60.1-0.4-0.10.2-0.20.10.4-0.40.40.00.1-0.7
Conditioned reinforcement - inactives0.20.30.70.70.4-0.3-0.4-0.00.40.8-0.20.80.90.6-0.3
Conditioned locomotion1.31.76.10.4-0.6-2.50.9-1.9-0.7-1.0-0.7-0.8-1.0-1.2-2.0
Patch foraging indifference point 0 sec0.40.82.6-1.6-1.60.90.3-0.8-0.6-0.4-1.3-0.5-0.5-0.5-0.5
Patch foraging indifference point AUC0.50.82.51.41.6-1.0-0.00.50.40.70.30.61.00.71.0
Delay disc. indifference point, 0s delay0.20.21.30.30.2-1.2-0.10.20.10.10.50.20.1-0.1-0.4
Delay disc. indifference point, 16s delay0.10.10.40.3-0.1-0.2-0.00.10.10.2-0.20.2-0.0-0.1-0.7
Delay disc. indifference point, 2s delay0.30.31.00.70.3-0.8-0.40.10.4-0.11.0-0.1-0.1-0.3-1.0
Delay disc. indifference point, 24s delay0.80.93.10.1-0.6-1.30.7-0.9-0.7-0.8-0.9-0.8-1.0-1.0-1.8
Delay disc. indifference point, 4s delay0.70.71.5-0.2-0.3-1.01.1-1.0-0.9-1.1-0.7-1.0-0.8-1.2-0.4
Delay disc. indifference point, 8s delay0.91.02.0-0.0-0.6-1.21.1-1.2-0.8-1.1-0.5-1.1-1.0-1.4-1.3
Indifference point function ln k0.30.61.30.60.61.1-0.50.80.90.90.51.00.80.60.5
Indifference point function log k0.30.61.30.60.61.1-0.50.80.90.90.51.00.80.60.5
Patch foraging total patch changes 0 sec0.40.72.5-1.5-1.61.10.1-0.7-0.5-0.3-1.2-0.3-0.4-0.4-0.4
Patch foraging total patch changes 12 sec0.40.51.9-0.4-0.21.4-0.30.70.40.6-0.20.70.80.70.8
Patch foraging total patch changes 18 sec0.60.93.1-1.8-1.50.60.6-0.9-0.9-0.5-1.6-0.6-0.4-0.60.2
Patch foraging total patch changes 24 sec0.20.42.3-0.8-0.91.5-0.90.20.20.20.10.30.20.1-0.3
Patch foraging total patch changes 6 sec0.30.41.3-1.1-1.2-0.2-0.1-0.8-0.4-0.4-0.8-0.30.0-0.2-0.3
Patch foraging time to switch 0 sec1.32.76.7-2.6-2.60.60.9-0.9-1.5-1.9-0.8-1.8-2.1-1.6-0.8
Patch foraging water rate 0 sec0.20.30.70.70.50.3-0.40.20.50.8-0.30.70.90.7-0.0
Patch foraging water rate 12 sec0.30.72.00.20.50.7-0.70.20.71.1-0.11.21.41.00.8
Patch foraging water rate 18 sec0.10.20.9-0.5-0.70.3-0.4-0.5-0.3-0.5-0.2-0.3-0.3-0.2-0.9
Patch foraging water rate 24 sec0.50.71.70.10.41.1-0.60.40.51.0-0.11.11.31.11.2
Patch foraging water rate 6 sec0.40.51.10.40.70.4-0.60.50.50.9-0.11.01.01.01.0
Seeking ratio, delayed vs. immediate footshock0.40.52.2-0.70.10.50.7-0.3-0.8-0.0-1.2-0.2-0.1-0.11.5
Distance traveled before self-admin0.60.83.2-0.6-0.10.01.4-1.0-1.2-0.4-1.8-0.4-0.1-0.61.2
Distance traveled after self-admin0.70.91.9-1.0-0.40.01.3-0.8-1.4-0.8-1.2-0.8-0.6-1.11.0
Extensor digitorum longus weight0.20.72.41.51.5-0.3-0.20.80.70.41.10.50.70.40.5
Bone: elastic displacement0.50.61.30.80.4-1.1-0.7-0.40.80.70.30.91.00.9-0.8
Bone: elastic work0.30.42.00.0-0.3-1.4-0.3-0.90.2-0.10.0-0.00.10.1-1.2
Bone: endosteal estimation2.96.411.9-0.4-0.4-3.53.4-2.6-2.9-2.8-2.7-2.9-2.7-2.6-0.8
Bone: endosteal perimeter1.22.66.8-0.10.0-1.62.6-1.4-2.0-1.8-1.7-2.0-1.8-1.80.0
Epididymis fat weight1.86.328.7-5.4-5.02.9-0.3-1.2-1.5-1.0-1.8-1.1-1.4-1.2-0.8
Delta time in closed arm before/after self-admin0.90.81.5-0.8-1.1-1.20.8-1.2-0.7-0.5-1.1-0.6-0.7-0.7-1.0
Delta time in open arm before/after self-admin0.10.10.50.20.40.3-0.50.40.40.20.70.20.20.30.2
Diff in mean of infusions in LGA sessions0.30.32.2-0.6-0.41.5-0.40.5-0.2-0.50.2-0.5-0.3-0.10.3
Delay discount exponential model param0.40.41.6-0.20.21.3-0.50.70.40.60.40.50.50.81.0
Extinction: sum of active levers before priming0.30.42.1-0.00.11.4-0.40.70.30.70.20.50.40.60.6
Active lever presses in extinction session 60.80.83.9-0.5-1.1-0.5-0.4-0.7-0.3-0.70.3-0.7-1.0-0.9-2.0
Bone: final force2.64.26.6-2.6-2.5-1.02.0-2.3-2.2-1.9-2.5-2.0-2.2-1.8-0.8
Bone: final moment2.03.24.8-2.1-2.2-1.11.7-2.1-1.9-1.7-2.2-1.7-1.9-1.6-0.9
Food consumed during 24 hour testing period2.23.05.6-1.6-1.6-0.31.5-1.3-2.1-2.3-1.1-2.3-2.2-2.4-0.7
Glucose0.91.46.22.52.1-0.7-0.00.81.00.81.00.70.61.0-0.3
Heart weight1.52.45.11.61.10.4-2.01.42.01.42.31.51.21.6-1.2
Delay discount hyperbolic model param0.30.31.6-0.4-0.11.3-0.30.50.20.40.10.30.30.60.9
Intermittent access intake day 1-15 change0.51.02.4-1.5-0.9-0.51.2-0.1-1.0-1.0-1.5-0.9-0.9-1.00.5
Intermittent access intake escalation0.61.22.8-1.7-1.2-0.61.2-0.2-1.0-1.1-1.5-1.2-1.1-1.10.1
Intermittent access intake escalation 20.30.31.2-0.2-0.2-1.10.7-0.1-0.3-0.4-0.6-0.6-0.6-0.3-0.1
Intermitt. access day 1 inactive lever presses0.72.56.90.61.41.4-0.82.01.21.70.31.82.11.62.6
Intermitt. access day 15 inactive lever presses0.20.31.3-0.4-0.0-0.31.0-0.6-0.60.1-1.1-0.2-0.1-0.30.6
Intermitt. access escalation Index1.01.44.5-0.00.91.2-0.71.70.91.10.61.11.31.22.1
Intermittent access day 1 total infusions1.21.93.21.50.50.3-1.71.21.71.51.81.71.11.1-1.5
Intermittent access day 15 total infusions0.10.20.6-0.0-0.3-0.4-0.30.80.40.40.20.50.10.2-0.7
Intermittent access terminal intake (last 3 days)0.20.20.70.4-0.1-0.6-0.30.50.50.40.20.60.20.2-0.8
Intermittent access total infusions0.40.51.20.80.1-0.4-0.80.50.80.60.81.00.50.4-1.1
Intermittent access day 1 locomotion0.10.10.30.50.0-0.40.1-0.4-0.10.0-0.20.40.2-0.3-0.6
Intermittent access day 15 total locomotion2.54.57.6-1.1-1.4-2.32.5-2.8-2.3-2.0-2.7-2.0-1.9-2.4-1.4
Intermittent access total locomotion1.11.32.90.0-0.6-1.51.1-1.7-1.2-1.1-1.3-0.8-0.8-1.4-1.3
Intermittent access standard deviation0.81.83.7-1.9-1.6-0.11.4-0.9-1.6-1.2-1.8-1.2-1.1-1.4-0.0
Left kidney weight1.46.513.2-1.8-2.0-2.03.6-3.2-2.9-2.3-3.6-2.2-2.4-2.4-0.8
Right kidney weight2.611.922.8-2.3-2.3-3.74.8-4.1-3.9-3.3-4.2-3.4-3.5-3.4-1.0
Cocaine induced anxiety0.20.31.70.10.7-0.80.3-0.1-0.10.20.10.20.30.21.3
Post-drug Anxiety0.20.20.5-0.30.1-0.70.4-0.1-0.5-0.60.1-0.7-0.4-0.50.6
Baseline Anxiety0.70.81.7-1.0-1.31.0-0.10.3-0.6-1.1-0.2-1.1-1.0-0.9-0.9
Tail length1.03.816.71.41.4-4.12.9-2.0-1.5-1.1-2.4-1.0-0.9-1.2-0.1
Length with tail1.87.723.71.10.6-4.94.2-3.2-2.6-2.4-3.1-2.3-2.2-2.3-1.4
Length without tail2.27.212.3-0.6-1.2-3.43.5-3.3-2.8-2.8-2.5-2.8-2.8-2.7-2.2
Times rat made contact with spout0.81.03.1-0.1-0.21.3-1.81.01.00.81.50.80.90.7-0.3
Lifetime Intake0.20.31.70.6-0.1-0.7-0.50.20.40.30.50.60.20.1-1.3
Liver weight, left1.52.65.7-0.3-0.2-1.12.4-1.6-2.0-1.8-1.8-1.9-1.8-1.9-0.0
Liver weight, right2.64.513.31.21.3-3.63.2-2.5-2.2-1.4-3.0-1.4-0.8-1.60.7
Locomotor activity0.30.53.1-0.20.50.00.6-0.2-0.10.4-1.20.60.80.51.8
Locomotor testing distance0.30.52.1-1.0-0.31.30.10.3-0.10.2-0.50.20.30.11.4
Locomotor testing rearing0.71.42.4-1.3-0.90.11.4-1.2-1.4-1.1-1.5-1.2-1.0-1.30.8
Locomotion in novel chamber0.81.03.30.20.11.8-1.11.31.01.00.91.10.80.90.0
Locomotion in novel chamber post-restriction1.22.02.8-1.5-1.6-0.11.3-1.2-1.7-1.6-1.3-1.7-1.7-1.7-0.9
Fecal boli incidents, locomotor time 10.50.81.8-0.6-1.00.40.1-0.9-0.6-1.00.2-1.0-1.1-1.1-1.4
Change in fecal boli incidents, locomotor task0.10.10.4-0.3-0.1-0.10.6-0.2-0.4-0.4-0.3-0.3-0.1-0.60.3
Time >=10cm from walls, locomotor time 13.13.35.2-2.3-1.9-0.21.9-1.8-2.1-2.1-1.7-2.1-1.9-2.10.3
Bouts of movement, locomotor time 10.20.21.2-0.00.50.60.10.4-0.10.1-0.10.10.2-0.11.1
Total resting periods, locomotor time 10.10.10.50.10.50.10.40.0-0.4-0.3-0.2-0.2-0.1-0.40.7
Rest time, locomotor task time 10.50.62.01.41.2-1.30.1-0.40.30.5-0.20.50.70.5-0.0
Distance moved, locomotor task time 10.40.61.6-1.3-1.10.80.5-0.1-0.7-0.8-0.4-0.8-0.9-0.6-0.1
Vertical activity count, locomotor time 11.23.06.5-2.6-2.40.41.2-0.8-1.8-2.1-0.4-2.2-2.2-1.9-0.6
Time >=10cm from walls, locomotor time 23.34.97.4-1.9-2.3-1.72.0-2.4-2.2-2.7-1.0-2.7-2.7-2.5-1.8
Bouts of movement, locomotor time 20.71.13.00.30.9-1.71.2-1.2-1.0-0.8-1.2-0.8-0.4-1.10.9
Total resting periods, locomotor time 20.50.83.00.81.5-1.70.7-0.9-0.5-0.2-0.7-0.20.2-0.61.2
Rest time, locomotor task time 20.40.61.90.71.1-0.50.3-0.4-0.00.6-0.90.61.00.31.4
Distance moved, locomotor task time 22.83.46.0-1.7-2.4-0.41.3-1.3-1.7-2.2-0.7-2.2-2.4-1.9-2.3
Vertical activity count, locomotor time 22.43.36.1-1.5-2.1-1.01.2-1.3-1.7-2.3-0.1-2.3-2.5-2.0-2.3
Light reinforcement 11.12.65.6-2.4-1.9-0.41.9-1.1-2.0-1.5-2.0-1.6-1.4-1.41.0
Light reinforcement 22.43.75.9-1.6-1.5-1.42.2-2.1-2.4-2.3-1.9-2.3-2.0-2.0-0.1
Bone: marrow area3.16.812.1-0.5-0.5-3.43.5-2.6-3.0-2.9-2.7-3.0-2.9-2.7-0.9
Bone: maximum diameter0.40.73.51.41.4-1.90.9-0.2-0.10.0-0.2-0.10.0-0.10.2
Bone: maximum force0.61.02.0-1.1-1.1-1.01.0-1.2-0.9-0.8-1.4-0.9-1.2-0.7-0.7
Bone: maximum moment0.40.71.3-0.6-0.8-1.20.7-1.1-0.7-0.6-1.1-0.7-1.0-0.5-0.9
Mean time between licks in bursts1.12.69.22.93.0-0.2-0.11.61.11.21.11.21.41.21.7
Mean num. licks in bursts0.30.41.7-0.7-0.90.6-0.8-0.3-0.0-0.40.5-0.4-0.4-0.5-1.3
Cd content in liver1.31.44.5-1.0-1.5-0.2-0.0-1.0-0.8-1.30.0-1.3-1.6-1.3-2.1
Co content in liver2.83.36.8-2.3-2.61.21.1-1.3-1.6-2.0-0.9-1.9-2.4-1.8-1.8
Cu content in liver1.92.25.2-0.4-0.21.9-2.31.81.61.42.11.41.11.40.4
Fe content in liver0.81.02.0-0.7-0.7-1.41.4-1.4-1.0-0.7-1.4-0.9-0.8-0.7-0.2
K content in liver1.61.52.81.71.60.4-0.71.21.31.31.31.41.31.30.4
Mg content in liver1.51.54.21.92.10.5-0.41.41.00.81.60.91.10.81.0
Mn content in liver1.01.15.22.12.3-1.01.10.3-0.00.00.00.10.5-0.01.0
Na content in liver0.50.51.50.20.50.8-0.20.50.50.8-0.00.91.00.81.2
Rb content in liver0.40.41.0-0.3-0.5-0.20.1-0.2-0.4-0.90.7-0.9-0.9-0.8-1.0
Se content in liver2.93.49.93.13.1-1.2-0.71.51.61.61.51.51.91.61.2
Sr content in liver0.50.42.3-0.2-0.7-0.4-0.2-0.5-0.3-0.5-0.1-0.5-0.8-0.3-1.5
Zn content in liver0.80.92.31.51.30.2-0.81.11.00.71.50.70.50.7-0.2
Bone: minimum diameter0.61.12.60.0-0.0-1.21.6-0.7-1.1-1.2-0.9-1.3-1.3-1.0-0.4
Time in familiar zone, hab. session 10.20.20.60.1-0.20.8-0.60.20.50.40.40.40.20.6-0.5
Time in novel zone, hab. session 10.30.31.70.10.3-1.30.7-0.7-0.5-0.3-0.5-0.30.1-0.50.4
Total zone transitions, hab. session 13.75.18.11.31.62.0-2.42.52.52.81.52.82.52.71.7
Total locomotion distance, hab. session 13.24.56.91.62.01.7-1.92.42.32.51.42.42.32.61.8
Locomotion velocity, hab. session 13.34.67.81.61.91.7-1.92.62.42.61.42.52.22.81.7
Time in familiar zone, hab. session 20.91.03.6-0.20.41.9-0.71.50.40.70.50.50.60.61.9
Time in novel zone, hab. session 21.81.86.4-0.2-0.8-2.50.8-1.9-0.7-1.1-0.4-1.0-1.0-1.0-2.4
Total zone transitions, hab. session 21.21.54.70.40.91.2-0.81.10.91.6-0.31.51.51.22.2
Total locomotion distance, hab. session 23.14.17.80.91.61.8-1.72.21.82.50.62.32.32.42.8
Locomotion velocity, hab. session 23.95.28.71.31.92.1-1.92.52.12.80.72.62.62.73.0
Novel to familiar place preference ratio0.30.32.2-0.1-0.4-1.5-0.1-0.40.30.4-0.00.30.30.3-0.7
Novelty place preference0.30.32.60.1-0.2-1.6-0.1-0.40.30.4-0.00.30.30.3-0.6
Time in novel zone, NPP test0.30.43.30.1-0.2-1.80.1-0.70.10.2-0.10.00.10.0-0.7
Total zone transitions, NPP test2.13.04.81.61.90.7-1.71.81.92.21.22.11.92.01.3
Total locomotion distance, NPP test1.11.62.70.90.90.7-1.61.41.51.61.11.41.21.70.3
Locomotion velocity, NPP test1.72.44.20.91.01.2-2.01.81.81.91.21.71.62.00.8
Intraocular pressure0.30.41.0-0.5-0.30.11.0-0.6-0.7-0.4-0.9-0.5-0.8-0.5-0.3
Delta distance traveled before/after self-admin0.20.30.9-0.3-0.4-0.1-0.40.10.1-0.40.9-0.4-0.6-0.5-0.9
Delta ambulatory time before/after self-admin0.20.20.7-0.4-0.4-0.3-0.1-0.0-0.1-0.50.9-0.5-0.7-0.6-0.5
Parametrial fat weight3.17.311.9-3.2-3.00.33.2-2.6-3.3-2.8-3.5-2.6-2.5-2.80.1
Pavlov. Cond. lever latency3.34.29.6-3.1-2.80.61.1-1.6-2.2-2.5-1.5-2.4-2.0-2.2-0.3
Pavlov. Cond. magazine entry latency2.02.67.82.82.8-0.9-0.71.21.51.61.01.61.61.30.6
Pavlov. Cond. change in total contacts0.50.52.01.41.2-0.40.4-0.00.50.80.10.80.50.4-0.1
Pavlov. Cond. index score2.73.49.53.12.9-1.0-0.81.31.92.11.12.11.81.80.3
Pavlov. Cond. latency score2.53.28.93.02.8-0.9-0.71.31.82.01.02.01.71.80.4
Pavlov. Cond. lever contacts2.12.56.32.52.2-0.8-0.71.11.71.91.01.81.51.7-0.0
Pavlov. Cond. magazine entry number2.22.86.5-2.5-2.60.11.1-1.6-1.7-1.8-1.4-1.8-1.7-1.4-0.7
Pavlov. Cond. intertrial magazine entries0.81.03.5-1.1-1.5-0.5-0.3-1.0-0.5-0.80.1-0.9-1.2-0.8-1.9
Pavlov. Cond. lever-magazine prob. diff.2.93.59.43.12.8-0.7-0.81.42.02.21.02.21.81.90.3
Pavlov. Cond. response bias3.03.79.53.13.0-0.7-1.01.62.02.11.42.12.01.70.6
Pavlov. Cond. lever latency1.31.84.0-1.2-0.9-1.71.7-1.5-1.6-1.1-2.0-0.9-0.8-1.00.8
Pavlov. Cond. magazine entry latency0.60.81.60.2-0.1-1.10.8-0.7-0.7-0.9-0.4-1.1-1.2-1.1-1.3
Pavlov. Cond. change in total contacts0.40.72.20.70.41.5-1.01.20.90.51.30.2-0.00.4-0.8
Pavlov. Cond. index score0.30.41.20.90.60.6-0.50.60.50.20.9-0.0-0.20.1-1.1
Pavlov. Cond. latency score0.20.30.80.80.50.7-0.30.50.40.20.7-0.1-0.20.0-0.9
Pavlov. Cond. lever contacts1.01.43.40.90.61.6-1.61.41.41.01.90.80.60.9-0.8
Pavlov. Cond. magazine entry number0.40.51.30.30.5-0.1-0.40.30.50.70.11.01.10.81.1
Pavlov. Cond. intertrial magazine entries0.71.15.01.01.60.40.01.30.40.31.00.50.80.22.2
Pavlov. Cond. lever-magazine prob. diff.0.20.31.20.80.40.7-0.40.50.40.10.8-0.2-0.3-0.0-1.1
Pavlov. Cond. response bias0.60.82.11.20.90.5-1.00.91.10.61.40.40.20.5-1.2
Time in closed arm before self-admin0.10.10.60.20.00.3-0.4-0.10.2-0.10.7-0.1-0.1-0.1-0.4
Time in closed arm after self-admin0.30.31.30.1-0.2-0.5-0.8-0.10.70.40.80.40.20.4-1.1
Time in open arm before self-admin0.50.50.90.90.8-0.3-0.50.70.80.90.40.90.90.90.1
Time in open arm after self-admin0.30.30.60.80.80.1-0.40.70.40.40.50.40.60.50.5
Bone: periosteal estimation1.02.25.8-0.2-0.1-2.42.1-1.5-1.6-1.4-1.7-1.6-1.5-1.3-0.3
Bone: periosteal perimeter0.20.41.5-0.1-0.1-0.21.2-0.3-0.8-0.8-0.6-0.9-0.8-0.60.1
Bone: post-yield work0.30.41.70.20.1-1.10.70.1-0.3-0.4-0.2-0.7-1.3-0.4-0.8
Progressive ratio test 1 active lever presses0.20.21.70.3-0.40.1-0.4-0.10.00.10.20.20.1-0.3-1.3
Progressive ratio test 1 breakpoint0.20.21.60.4-0.30.1-0.6-0.00.20.20.40.40.2-0.1-1.3
Progressive ratio test 1 inactive lever presses0.30.41.2-1.0-1.10.60.5-0.1-0.7-0.3-1.0-0.1-0.3-0.4-0.1
Progressive ratio test 2 active lever presses0.10.10.20.3-0.0-0.2-0.30.30.20.50.00.50.30.3-0.5
Progressive ratio test 2 breakpoint0.10.10.30.3-0.0-0.1-0.40.40.30.50.10.50.40.3-0.5
Progressive ratio test 2 inactive lever presses0.20.31.01.00.6-0.8-0.30.00.50.70.20.50.60.5-0.6
Incentive Sensitization - Responses1.11.53.50.50.81.3-1.01.91.11.50.51.51.41.41.0
Incentive Sensitization - Breakpoint0.91.12.80.30.61.2-0.81.70.91.30.21.31.21.21.0
Sum of active levers in priming session hrs 5-60.20.20.50.50.30.1-0.40.60.50.20.70.30.20.5-0.2
Progressive ratio2.74.26.8-2.1-1.9-0.92.3-2.6-2.5-2.0-2.4-2.1-1.7-2.50.0
Food seeking constrained by brief footshock0.30.42.4-0.2-0.90.5-0.5-0.4-0.2-0.50.1-0.5-0.6-0.3-1.5
Seeking ratio, punishment vs. effort2.02.84.51.81.30.7-2.12.02.11.61.91.71.42.1-0.4
Retroperitoneal fat weight0.52.15.8-1.1-1.0-1.02.0-1.8-1.7-1.2-2.4-1.2-1.1-1.3-0.2
Reaction time number correct0.71.33.2-1.8-1.6-0.10.7-1.1-1.3-1.3-1.4-1.1-0.9-0.9-0.0
Reaction time mean minus median0.30.82.71.71.4-1.41.30.1-0.4-0.3-0.5-0.2-0.4-0.3-0.0
Reaction time mean minus median AUC0.40.93.11.61.0-1.81.1-0.2-0.4-0.6-0.2-0.5-0.8-0.6-1.2
Reaction time num false alarms0.60.92.60.81.21.40.20.90.51.0-0.40.71.00.71.6
Reaction time num false alarms AUC1.11.73.31.21.51.6-0.41.41.11.50.11.21.41.21.8
Reaction time trials correct on left0.71.33.2-1.8-1.6-0.10.7-1.1-1.3-1.3-1.4-1.1-0.9-0.9-0.0
Reaction time trials on left0.71.33.2-1.8-1.6-0.00.7-1.1-1.4-1.3-1.4-1.1-1.0-1.0-0.1
Reaction time mean0.40.61.70.70.3-1.00.9-0.2-0.5-0.80.0-1.0-1.3-0.7-1.1
Reaction time mean AUC0.71.12.60.50.1-1.21.3-0.5-0.8-1.2-0.3-1.3-1.6-1.0-1.4
Median of all reaction times0.50.72.10.1-0.2-0.60.7-0.3-0.5-0.90.1-1.2-1.5-0.7-1.3
Reaction time omissions0.30.41.40.30.60.31.20.0-0.7-0.6-0.7-0.6-0.4-0.50.8
Reaction time false alarm rate2.33.15.62.12.41.3-0.81.91.82.21.01.81.91.71.6
Reaction time premature initiation rate0.30.43.2-0.3-0.31.8-0.30.70.20.10.50.20.10.10.0
Reaction time premature initiations0.40.72.4-1.5-1.41.60.2-0.1-0.7-0.8-0.4-0.6-0.6-0.7-0.2
Std. dev. reaction times0.40.72.91.71.4-1.41.00.2-0.2-0.4-0.1-0.4-0.7-0.4-0.6
Reaction time trials completed0.71.33.2-1.8-1.6-0.00.7-1.1-1.4-1.3-1.4-1.1-1.0-1.0-0.1
Reaction time trials AUC0.71.43.4-1.8-1.6-0.10.7-1.1-1.4-1.4-1.4-1.2-1.0-1.0-0.0
Run reversals in cocaine runway, females0.40.43.1-0.1-0.80.1-0.50.10.2-0.10.70.1-0.6-0.4-1.8
Run reversals in cocaine runway, males0.80.83.41.51.4-1.80.8-0.80.20.2-0.60.30.40.00.1
Latency to leave start box in cocaine runway0.70.81.50.40.50.9-1.11.21.10.91.00.80.91.20.2
Latency to leave start box in cocaine runway, F0.40.51.00.20.30.4-1.01.00.80.60.80.60.61.00.1
Latency to leave start box in cocaine runway, M0.20.20.40.10.20.7-0.20.60.60.40.20.40.50.40.3
Std. dev. time between licks in bursts1.62.27.62.62.8-0.70.70.70.71.1-0.21.11.41.31.9
Total sessions with >9 infusions0.20.20.50.40.0-0.2-0.50.20.40.60.50.60.50.2-0.7
Short access day 1 total inactive lever presses0.30.42.41.00.5-1.50.3-0.40.20.10.30.0-0.3-0.2-1.0
Short access day 10 total inactive lever presses0.71.810.3-0.60.71.90.21.30.11.0-0.80.91.40.93.2
Short access day 1 total infusions0.40.60.90.80.40.3-0.90.60.80.90.91.00.70.6-0.8
Short access day 10 total infusions0.10.10.5-0.2-0.30.7-0.40.50.10.20.10.50.30.1-0.3
Short access total infusions0.20.21.40.3-0.20.1-0.50.40.40.40.60.50.10.1-1.2
Short access day 1 locomotion0.50.61.30.30.70.5-0.40.80.31.2-0.21.11.10.61.1
Short access day 10 total locomotion0.20.41.70.10.60.80.20.4-0.40.4-0.80.50.7-0.11.3
Short access total locomotion0.10.10.3-0.10.10.10.2-0.0-0.40.1-0.60.10.3-0.40.4
One hour access (0.3 mA shock)2.73.24.91.31.50.6-1.82.22.02.21.82.22.01.91.1
Compulsive drug intake1.31.64.00.10.90.7-1.22.01.31.11.81.11.01.11.7
One hour access (shock baseline)0.20.41.11.00.4-0.9-0.3-0.20.50.40.10.50.50.3-1.0
Social response proportion0.00.10.40.30.2-0.6-0.0-0.20.1-0.10.2-0.00.10.1-0.1
Social responses0.10.10.90.10.30.50.10.40.00.1-0.10.20.30.31.0
Social time0.91.38.00.91.6-0.20.61.10.20.6-0.10.61.10.52.8
Soleus weight1.03.015.82.72.6-4.01.9-1.1-0.5-0.2-0.7-0.20.4-0.20.4
Bone: stiffness0.50.81.8-1.3-1.10.30.8-0.5-0.9-0.7-1.0-0.7-1.3-0.70.0
Tibialis anterior weight0.30.92.20.10.31.4-1.21.41.00.71.50.60.80.70.7
Time to tail flick, vehicle, before self-admin1.81.95.4-1.00.1-0.22.2-0.6-1.7-1.2-2.2-1.1-0.4-0.72.3
Time to tail flick, vehicle, after self-admin0.10.20.90.10.2-0.2-0.60.60.60.21.00.20.20.2-0.0
Time to tail flick, test, before self-admin0.90.92.80.10.71.1-0.40.60.41.2-0.61.11.31.01.7
Time to tail flick, test, after self-admin0.40.41.40.91.2-1.10.10.20.40.50.10.40.50.20.6
Delta time to tail flick, vehicle, before/after SA2.01.95.60.6-0.30.2-2.40.81.70.92.40.90.30.7-2.2
Delta time to tail flick, test, before/after SA0.40.50.9-0.4-0.4-0.80.7-0.5-0.5-0.80.0-0.9-0.9-1.0-0.5
Tibia length1.95.211.4-0.8-0.4-2.93.4-2.4-2.7-2.5-2.8-2.4-2.1-2.30.2
Ambulatory time before self-admin0.20.41.7-0.30.10.50.7-0.3-0.70.0-1.30.10.3-0.11.0
Ambulatory time after self-admin0.30.30.8-0.7-0.30.30.7-0.5-0.9-0.5-0.7-0.5-0.3-0.70.7
Bone: tissue strength0.40.41.3-0.7-1.0-0.2-0.1-0.6-0.3-0.4-0.5-0.5-0.7-0.3-1.2
Total heroin consumption0.40.42.0-0.40.21.4-0.10.9-0.0-0.00.10.00.20.31.4
Bone: trabecular number0.30.51.60.00.00.9-1.21.00.80.41.20.60.40.3-0.3
Bone: trabecular spacing1.11.52.8-0.8-0.9-0.81.7-1.5-1.5-1.3-1.5-1.4-1.2-1.2-0.4
Bone: trabecular thickness0.40.61.4-0.4-0.4-1.20.6-0.9-0.6-0.8-0.7-0.7-0.8-0.8-0.8
Bone: trabecular tissue density0.30.41.31.10.9-1.10.2-0.30.30.5-0.40.50.40.5-0.1
Water consumed over 24 hours0.20.21.00.10.20.5-0.80.50.40.11.00.20.40.00.2
Number of responses in last shaping day2.32.65.72.41.5-0.6-1.40.91.92.01.71.71.51.7-0.7