Hub : Genes

Ppard

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Ppard 0.07 0.04 3.3e-06 0.06 0.05 0.04 0.05 4.5e-06 8.3e-06 2.1e-04 8.2e-06
2 OFC gene expression Ppard 0.19 0.1 1.3e-04 0.22 0.21 0.16 0.21 7.1e-06 1.1e-05 1.1e-04 1.2e-05
3 BLA alternative TSS NM_013141.2 0.15 0.09 3.2e-03 0 0.01 0.02 0.01 2.2e-01 1.5e-01 3.5e-02 1.0e-01
4 Adipose alternative TSS XM_006256167.5 0.04 0.03 1.5e-03 0.02 0.02 0.01 0.02 2.2e-03 9.0e-04 1.1e-02 9.6e-04
5 NAcc gene expression Ppard 0.13 0.06 2.6e-15 0.09 0.1 0.1 0.1 3.6e-13 3.5e-15 2.3e-15 9.0e-15
6 IC gene expression Ppard 0.63 0.18 1.6e-09 0.22 0.17 0.22 0.22 7.9e-10 1.7e-07 8.2e-10 7.6e-10
7 Adipose mRNA stability Ppard 0.04 0.03 6.3e-04 0.02 0.02 0.01 0.02 2.0e-03 2.2e-03 8.2e-03 3.9e-03
8 pVTA gene expression Ppard 0.09 0.06 1.2e-05 0.07 0.06 0.06 0.07 2.4e-06 1.2e-05 1.6e-05 2.5e-06
9 BLA gene expression Ppard 0.27 0.12 3.4e-10 0.22 0.16 0.18 0.2 1.1e-11 5.8e-09 9.6e-10 1.1e-10
10 PL gene expression Ppard 0.17 0.07 0.0e+00 0.14 0.15 0.16 0.16 9.6e-15 5.0e-16 8.1e-17 6.1e-17
11 Adipose gene expression Ppard 0.13 0.06 0.0e+00 0.2 0.19 0.19 0.19 3.2e-21 7.3e-21 3.3e-20 1.2e-20
12 PL mRNA stability Ppard 0.03 0.03 9.7e-03 0.01 0.01 0.01 0.01 2.0e-02 1.7e-02 1.5e-02 4.0e-02
13 pVTA mRNA stability Ppard 0.06 0.04 6.3e-03 0.01 0.02 0 0.02 8.5e-02 6.1e-03 2.0e-01 1.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.60.10.1-0.4-0.8-0.30.0-0.5-0.6-0.20.10.10.3-0.4
Area under the delay curve0.30.51.8-0.10.31.40.60.7-0.60.30.30.5-0.50.90.6-1.0
BMI with tail1.24.211.63.43.2-0.11.61.7-1.72.01.81.8-1.91.8-2.6-0.8
BMI without tail0.52.86.32.42.20.81.81.7-1.32.52.11.2-1.41.5-1.4-0.5
Body weight2.812.323.52.32.63.54.84.3-3.64.44.13.5-3.73.7-0.4-1.9
Weight adjusted by age0.51.36.6-0.40.22.60.71.5-0.9-0.10.00.8-1.01.11.0-1.7
Bone surface0.10.30.8-0.5-0.70.90.40.4-0.50.50.30.3-0.20.50.80.1
Bone volume0.10.21.0-0.0-0.01.00.40.7-0.50.60.40.3-0.30.50.4-0.3
Breakpoint value in progressive ratio session0.40.72.11.41.0-1.40.2-0.2-0.80.00.20.8-0.80.6-1.20.4
Number of licking bursts0.30.92.1-1.0-1.2-0.1-0.4-1.11.1-0.6-0.5-1.11.3-1.1-0.01.5
Context. condit. distance diff. score0.81.03.9-1.9-2.00.3-0.2-0.60.7-0.7-0.6-0.70.7-0.51.00.9
Locomotion velocity, session 11.51.74.3-2.1-1.90.5-1.0-1.11.6-1.2-1.5-1.51.4-1.20.40.1
Locomotion distance, session 13.03.86.0-1.6-1.8-1.3-2.4-2.32.4-1.9-2.2-2.32.0-2.3-0.71.0
Locomotion velocity, session 20.50.61.7-1.1-1.30.1-0.2-1.00.6-0.9-0.7-0.60.9-0.40.11.1
Locomotion distance, session 20.81.22.3-1.2-1.1-0.8-1.3-1.51.1-1.2-1.3-1.10.9-1.20.10.3
Locomotion velocity, session 30.91.14.6-0.7-0.91.00.20.31.00.50.2-1.11.3-1.0-2.11.2
Locomotion distance, session 31.41.73.5-1.2-1.3-0.6-0.9-0.81.9-0.1-0.7-1.91.8-1.6-1.41.1
Stereotopy head waving bouts, day 31.01.24.7-0.3-0.42.21.91.3-0.91.21.20.8-0.50.90.20.4
Stereotopy head waving duration, day 30.40.53.4-0.7-0.61.80.60.6-0.4-0.3-0.00.40.00.40.9-0.1
Locomotion velocity, session 70.50.51.1-1.1-0.80.6-0.7-0.40.6-0.9-1.0-0.60.3-0.6-0.2-0.8
Locomotion distance, session 71.21.52.8-1.7-1.4-0.3-1.4-1.21.1-1.5-1.6-1.20.8-1.10.6-0.7
Stereotopy head waving bouts, day 70.60.71.9-0.3-0.31.20.91.10.41.40.8-0.50.9-0.3-1.00.7
Stereotopy head waving duration, day 70.50.61.60.10.10.91.01.00.21.30.9-0.20.5-0.1-1.20.6
Locomotion velocity, session 80.91.14.6-2.1-2.11.30.5-0.40.1-0.2-0.1-0.30.4-0.01.50.7
Locomotion distance, session 81.21.75.5-2.2-2.3-0.1-0.9-1.41.2-1.0-1.1-1.31.3-1.10.61.1
Degree of sensitization distance1.31.34.50.10.21.00.50.2-1.6-0.8-0.11.5-1.61.52.1-1.2
Degree of sensitization stereotypy0.60.72.0-0.4-0.5-0.1-0.30.11.10.4-0.1-1.21.4-0.9-1.20.9
Conditioned locomotion2.63.15.41.21.31.12.32.0-2.21.92.12.1-1.92.10.6-0.4
Cocaine response after cond. corrected0.50.71.11.00.80.90.80.9-0.71.01.10.7-0.60.8-0.80.5
Cocaine response after cond. not corrected0.40.61.80.30.11.30.90.9-0.61.11.00.6-0.30.7-0.30.7
Cocaine response before conditioning0.40.51.9-1.4-1.31.00.40.10.1-0.0-0.1-0.10.30.11.20.1
Saline control response1.82.45.62.32.40.40.71.7-1.90.71.11.9-1.81.9-0.2-1.3
Bone: connectivity density0.10.20.7-0.00.0-0.4-0.5-0.3-0.4-0.8-0.70.2-0.30.50.6-0.6
Bone: cortical apparent density0.30.51.81.31.2-0.8-0.10.5-0.30.80.70.3-0.40.4-1.00.2
Bone: cortical area0.10.10.5-0.2-0.20.4-0.1-0.30.5-0.2-0.3-0.50.2-0.5-0.70.1
Bone: cortical porosity0.70.81.9-1.4-1.00.7-0.5-0.31.0-0.7-0.9-1.11.0-1.20.1-0.6
Bone: cortical porosity1.01.12.6-1.6-1.01.5-0.5-0.20.9-1.1-1.1-0.80.7-1.00.9-1.3
Bone: cortical thickness1.11.84.50.60.5-1.7-1.8-1.21.5-0.9-1.2-1.61.1-1.5-2.10.3
Bone: cortical thickness0.70.93.61.91.7-0.7-0.5-0.1-0.5-0.3-0.10.3-0.50.2-1.8-0.2
Bone: cortical tissue density0.30.51.51.21.1-0.60.10.6-0.40.90.80.4-0.40.5-0.90.2
Condit. Reinf. active minus inactive responses0.60.62.5-0.7-0.40.4-0.8-0.2-0.0-1.2-1.00.0-0.2-0.11.6-1.3
Condit. Reinf. active-inactive response ratio0.50.50.90.80.9-0.20.10.5-0.9-0.00.20.9-0.90.90.9-0.8
Condit. Reinf. active responses0.40.52.3-0.20.20.1-0.40.2-0.4-0.7-0.60.5-0.80.31.2-1.5
Condit. Reinf. inactive responses0.20.20.70.00.3-0.5-0.6-0.30.1-0.8-0.7-0.0-0.2-0.1-0.1-0.9
Incentive salience index mean0.40.51.8-1.1-0.90.3-0.5-0.40.3-0.9-0.9-0.30.0-0.31.4-0.8
Condit. Reinf. lever presses0.20.41.2-1.1-1.10.1-0.0-0.70.6-0.5-0.5-0.40.2-0.30.8-0.0
Condit. Reinf. active minus inactive responses0.40.63.0-1.1-1.0-0.5-0.4-0.70.2-0.7-0.7-0.10.1-0.31.7-0.3
Condit. Reinf. active-inactive response ratio0.20.32.2-0.8-0.7-0.00.0-0.20.0-0.1-0.10.2-0.1-0.11.5-0.2
Condit. Reinf. active responses0.40.61.7-1.0-1.0-0.6-0.6-1.00.4-1.1-1.0-0.30.3-0.41.3-0.2
Condit. Reinf. inactive responses0.00.00.10.0-0.00.00.0-0.2-0.2-0.3-0.3-0.0-0.00.3-0.30.0
Condit. Reinf. lever presses2.23.16.7-1.5-1.2-2.5-2.1-2.21.2-2.6-2.3-1.11.0-1.22.1-0.5
Condit. Reinf. lever reinforcers received0.91.32.5-1.4-1.3-0.9-1.0-1.40.8-1.6-1.5-0.70.6-0.81.4-0.1
Conditioned reinforcement - actives0.00.10.6-0.10.40.10.20.20.40.40.1-0.40.0-0.10.3-0.7
Conditioned reinforcement - inactives0.20.52.7-0.7-0.40.3-0.40.00.80.2-0.2-0.80.9-0.61.6-0.3
Conditioned locomotion1.21.76.5-0.40.62.60.91.9-1.00.70.50.8-1.01.21.4-2.0
Patch foraging indifference point 0 sec0.30.82.61.61.6-1.00.30.8-0.41.30.70.5-0.50.50.0-0.5
Patch foraging indifference point AUC0.30.72.5-1.4-1.61.0-0.0-0.50.7-0.3-0.3-0.61.0-0.70.21.0
Delay disc. indifference point, 0s delay0.10.21.4-0.3-0.21.2-0.1-0.20.1-0.5-0.2-0.20.10.1-0.2-0.4
Delay disc. indifference point, 16s delay0.10.10.4-0.30.10.3-0.0-0.10.20.20.1-0.2-0.00.10.6-0.7
Delay disc. indifference point, 2s delay0.40.41.3-0.7-0.30.9-0.4-0.1-0.1-1.0-0.70.1-0.10.31.2-1.0
Delay disc. indifference point, 24s delay0.60.93.1-0.10.61.40.70.9-0.80.90.60.8-1.01.01.2-1.8
Delay disc. indifference point, 4s delay0.60.71.50.20.31.01.11.0-1.10.70.71.0-0.81.20.3-0.4
Delay disc. indifference point, 8s delay0.61.02.00.00.61.31.11.2-1.10.50.51.1-1.01.41.2-1.3
Indifference point function ln k0.20.51.4-0.6-0.6-1.2-0.5-0.80.9-0.5-0.8-1.00.8-0.6-0.10.5
Indifference point function log k0.20.51.4-0.6-0.6-1.2-0.5-0.80.9-0.5-0.8-1.00.8-0.6-0.10.5
Patch foraging total patch changes 0 sec0.20.72.51.51.6-1.10.10.7-0.31.20.60.3-0.40.4-0.1-0.4
Patch foraging total patch changes 12 sec0.30.41.80.40.2-1.4-0.3-0.70.60.2-0.2-0.70.8-0.7-0.60.8
Patch foraging total patch changes 18 sec0.40.93.11.81.5-0.60.60.9-0.51.61.00.6-0.40.6-0.70.2
Patch foraging total patch changes 24 sec0.10.42.30.80.9-1.5-0.9-0.20.2-0.1-0.2-0.30.2-0.1-0.1-0.3
Patch foraging total patch changes 6 sec0.20.41.31.11.20.2-0.10.8-0.40.80.50.30.00.2-0.1-0.3
Patch foraging time to switch 0 sec0.72.56.72.62.6-0.50.90.9-1.90.81.11.8-2.11.6-1.0-0.8
Patch foraging water rate 0 sec0.10.30.7-0.7-0.5-0.4-0.4-0.20.80.3-0.1-0.70.9-0.70.6-0.0
Patch foraging water rate 12 sec0.20.72.0-0.2-0.5-0.7-0.7-0.21.10.1-0.2-1.21.4-1.0-1.00.8
Patch foraging water rate 18 sec0.20.31.90.50.7-0.3-0.40.5-0.50.20.30.3-0.30.21.4-0.9
Patch foraging water rate 24 sec0.50.71.7-0.1-0.4-1.1-0.6-0.41.00.10.0-1.11.3-1.1-0.71.2
Patch foraging water rate 6 sec0.30.51.1-0.4-0.7-0.4-0.6-0.50.90.1-0.0-1.01.0-1.0-0.71.0
Seeking ratio, delayed vs. immediate footshock0.40.52.20.7-0.1-0.60.70.3-0.01.21.10.2-0.00.1-0.51.5
Distance traveled before self-admin0.51.03.20.60.1-0.11.41.0-0.41.81.70.4-0.10.6-1.21.2
Distance traveled after self-admin0.50.92.71.00.4-0.11.30.8-0.81.21.70.8-0.61.1-0.51.0
Extensor digitorum longus weight0.20.92.8-1.5-1.50.2-0.2-0.80.4-1.1-1.0-0.50.7-0.41.70.5
Bone: elastic displacement0.40.51.4-0.8-0.41.2-0.70.40.7-0.3-0.7-0.91.0-0.90.2-0.8
Bone: elastic work0.30.42.1-0.00.31.4-0.30.9-0.1-0.0-0.30.00.1-0.10.4-1.2
Bone: endosteal estimation2.56.111.70.40.43.43.42.6-2.82.72.82.9-2.72.61.9-0.8
Bone: endosteal perimeter1.02.56.80.1-0.01.62.61.4-1.81.71.92.0-1.81.80.90.0
Epididymis fat weight1.47.328.75.45.0-2.7-0.31.2-1.01.81.61.1-1.41.2-4.4-0.8
Delta time in closed arm before/after self-admin0.90.81.70.81.11.30.81.2-0.51.10.80.6-0.70.7-0.7-1.0
Delta time in open arm before/after self-admin0.10.10.5-0.2-0.4-0.3-0.5-0.40.2-0.7-0.6-0.20.2-0.3-0.00.2
Diff in mean of infusions in LGA sessions0.20.32.30.60.4-1.5-0.4-0.5-0.5-0.20.10.5-0.30.10.30.3
Delay discount exponential model param0.30.51.80.2-0.2-1.3-0.5-0.70.6-0.4-0.3-0.50.5-0.8-0.71.0
Extinction: sum of active levers before priming0.30.42.30.0-0.1-1.5-0.4-0.70.7-0.2-0.0-0.50.4-0.6-0.80.6
Active lever presses in extinction session 60.80.83.90.51.10.5-0.40.7-0.7-0.3-0.00.7-1.00.91.3-2.0
Bone: final force2.54.06.62.62.51.02.02.3-1.92.52.32.0-2.21.8-1.4-0.8
Bone: final moment1.93.14.82.12.21.11.72.1-1.72.22.01.7-1.91.6-1.0-0.9
Food consumed during 24 hour testing period1.42.75.61.61.60.21.51.3-2.31.11.52.3-2.22.41.0-0.7
Glucose1.01.66.2-2.5-2.10.7-0.0-0.80.8-1.0-1.0-0.70.6-1.02.2-0.3
Heart weight1.62.65.1-1.6-1.1-0.3-2.0-1.41.4-2.3-2.3-1.51.2-1.62.1-1.2
Delay discount hyperbolic model param0.30.31.70.40.1-1.3-0.3-0.50.4-0.10.0-0.30.3-0.6-0.80.9
Intermittent access intake day 1-15 change0.21.02.41.50.90.41.20.1-1.01.51.00.9-0.91.0-1.20.5
Intermittent access intake escalation0.21.22.81.71.20.61.20.2-1.11.51.01.2-1.11.1-1.10.1
Intermittent access intake escalation 20.20.31.20.20.21.10.70.1-0.40.60.20.6-0.60.30.1-0.1
Intermitt. access day 1 inactive lever presses0.22.46.9-0.6-1.4-1.6-0.8-2.01.7-0.3-0.7-1.82.1-1.6-1.02.6
Intermitt. access day 15 inactive lever presses0.10.31.30.40.00.21.00.60.11.11.00.2-0.10.3-0.10.6
Intermitt. access escalation Index0.61.76.00.0-0.9-1.3-0.7-1.71.1-0.6-0.6-1.11.3-1.2-2.52.1
Intermittent access day 1 total infusions0.72.03.4-1.5-0.5-0.2-1.7-1.21.5-1.8-1.8-1.71.1-1.11.6-1.5
Intermittent access day 15 total infusions0.10.20.60.00.30.5-0.3-0.80.4-0.2-0.4-0.50.1-0.2-0.1-0.7
Intermittent access terminal intake (last 3 days)0.10.20.7-0.40.10.7-0.3-0.50.4-0.2-0.5-0.60.2-0.20.0-0.8
Intermittent access total infusions0.40.51.2-0.8-0.10.4-0.8-0.50.6-0.8-0.8-1.00.5-0.40.9-1.1
Intermittent access day 1 locomotion0.10.10.6-0.5-0.00.40.10.40.00.20.3-0.40.20.30.8-0.6
Intermittent access day 15 total locomotion1.14.27.61.11.42.32.52.8-2.02.72.32.0-1.92.40.9-1.4
Intermittent access total locomotion1.21.53.2-0.00.61.51.11.7-1.11.31.20.8-0.81.41.8-1.3
Intermittent access standard deviation0.31.83.71.91.60.01.40.9-1.21.81.71.2-1.11.4-1.2-0.0
Left kidney weight0.86.213.21.82.02.03.63.2-2.33.63.22.2-2.42.4-1.2-0.8
Right kidney weight1.611.322.82.32.33.84.84.1-3.34.24.13.4-3.53.4-1.6-1.0
Cocaine induced anxiety0.10.41.7-0.1-0.70.70.30.10.2-0.10.3-0.20.3-0.2-1.21.3
Post-drug Anxiety0.20.20.50.3-0.10.70.40.1-0.6-0.10.30.7-0.40.5-0.30.6
Baseline Anxiety0.40.71.71.01.3-1.0-0.1-0.3-1.10.20.11.1-1.00.91.0-0.9
Tail length0.73.816.4-1.4-1.44.12.92.0-1.12.42.11.0-0.91.21.4-0.1
Length with tail1.77.723.0-1.1-0.64.84.23.2-2.43.13.02.3-2.22.32.5-1.4
Length without tail1.36.712.30.61.23.43.53.3-2.82.52.62.8-2.82.71.2-2.2
Times rat made contact with spout0.80.93.10.10.2-1.3-1.8-1.00.8-1.5-1.3-0.80.9-0.70.1-0.3
Lifetime Intake0.30.31.7-0.60.10.7-0.5-0.20.3-0.5-0.5-0.60.2-0.10.8-1.3
Liver weight, left1.42.45.70.30.21.02.41.6-1.81.82.01.9-1.81.90.7-0.0
Liver weight, right2.64.612.5-1.2-1.33.53.22.5-1.43.02.71.4-0.81.61.80.7
Locomotor activity0.30.53.10.2-0.5-0.10.60.20.41.20.6-0.60.8-0.5-0.61.8
Locomotor testing distance0.20.52.11.00.3-1.30.1-0.30.20.50.3-0.20.3-0.1-1.01.4
Locomotor testing rearing0.41.32.41.30.9-0.21.41.2-1.11.51.51.2-1.01.3-0.70.8
Locomotion in novel chamber0.70.93.5-0.2-0.1-1.9-1.1-1.31.0-0.9-1.0-1.10.8-0.90.50.0
Locomotion in novel chamber post-restriction0.61.82.81.51.60.21.31.2-1.61.31.51.7-1.71.7-0.3-0.9
Fecal boli incidents, locomotor time 10.30.81.80.61.0-0.40.10.9-1.0-0.20.21.0-1.11.11.2-1.4
Change in fecal boli incidents, locomotor task0.10.10.40.30.10.10.60.2-0.40.30.20.3-0.10.6-0.40.3
Time >=10cm from walls, locomotor time 12.63.25.22.31.90.11.91.8-2.11.71.92.1-1.82.1-1.90.3
Bouts of movement, locomotor time 10.10.21.20.0-0.5-0.70.1-0.40.10.10.1-0.10.20.1-0.41.1
Total resting periods, locomotor time 10.10.10.5-0.1-0.5-0.10.4-0.0-0.30.20.30.2-0.10.40.10.7
Rest time, locomotor task time 10.30.52.0-1.4-1.21.40.10.40.50.2-0.0-0.50.7-0.5-0.0-0.0
Distance moved, locomotor task time 10.20.51.61.31.1-0.80.50.0-0.80.40.70.8-0.90.60.2-0.1
Vertical activity count, locomotor time 10.42.66.52.62.4-0.41.20.8-2.10.41.32.2-2.21.9-0.4-0.6
Time >=10cm from walls, locomotor time 21.64.57.41.92.31.82.02.4-2.71.01.62.7-2.72.5-1.1-1.8
Bouts of movement, locomotor time 20.31.02.8-0.3-0.91.71.21.2-0.81.21.00.8-0.41.1-0.00.9
Total resting periods, locomotor time 20.20.82.8-0.8-1.51.70.70.9-0.20.70.60.20.20.60.11.2
Rest time, locomotor task time 20.30.51.9-0.7-1.10.40.30.40.60.90.5-0.61.0-0.3-0.21.4
Distance moved, locomotor task time 22.33.16.01.72.40.51.31.3-2.20.71.22.2-2.41.91.0-2.3
Vertical activity count, locomotor time 21.33.06.11.52.11.11.21.3-2.30.11.12.3-2.52.00.8-2.3
Light reinforcement 10.73.06.52.41.90.31.91.1-1.52.02.21.6-1.41.4-2.51.0
Light reinforcement 21.63.56.31.61.51.42.22.1-2.31.92.52.3-2.02.0-1.1-0.1
Bone: marrow area2.66.512.10.50.53.43.52.6-2.92.72.93.0-2.92.71.9-0.9
Bone: maximum diameter0.30.73.4-1.4-1.41.80.90.20.00.20.20.10.00.10.90.2
Bone: maximum force0.51.02.01.11.11.01.01.2-0.81.41.10.9-1.20.7-0.6-0.7
Bone: maximum moment0.40.71.30.60.81.10.71.1-0.61.10.80.7-1.00.5-0.1-0.9
Mean time between licks in bursts0.42.79.2-2.9-3.00.1-0.1-1.61.2-1.1-1.0-1.21.4-1.21.81.7
Mean num. licks in bursts0.10.41.70.70.9-0.6-0.80.3-0.4-0.5-0.40.4-0.40.50.1-1.3
Cd content in liver1.31.44.51.01.50.2-0.01.0-1.3-0.00.31.3-1.61.31.3-2.1
Co content in liver2.52.96.82.32.6-1.11.11.3-2.00.91.11.9-2.41.8-0.6-1.8
Cu content in liver1.82.25.20.40.2-1.9-2.3-1.81.4-2.1-1.8-1.41.1-1.4-1.10.4
Fe content in liver0.91.12.10.70.71.51.41.4-0.71.41.30.9-0.80.7-0.9-0.2
K content in liver1.41.42.8-1.7-1.6-0.4-0.7-1.21.3-1.3-1.2-1.41.3-1.30.60.4
Mg content in liver1.41.54.2-1.9-2.1-0.5-0.4-1.40.8-1.6-1.2-0.91.1-0.81.11.0
Mn content in liver1.11.25.2-2.1-2.31.01.1-0.30.0-0.0-0.0-0.10.50.01.71.0
Na content in liver0.50.51.5-0.2-0.5-0.7-0.2-0.50.80.0-0.2-0.91.0-0.8-0.91.2
Rb content in liver0.40.51.10.30.50.20.10.2-0.9-0.7-0.30.9-0.90.81.0-1.0
Se content in liver2.83.39.9-3.1-3.11.2-0.7-1.51.6-1.5-1.4-1.51.9-1.61.71.2
Sr content in liver0.60.52.30.20.70.3-0.20.5-0.50.10.10.5-0.80.31.3-1.5
Zn content in liver0.91.12.5-1.5-1.3-0.2-0.8-1.10.7-1.5-1.2-0.70.5-0.71.6-0.2
Bone: minimum diameter0.51.02.6-0.00.01.11.60.7-1.20.91.01.3-1.31.00.9-0.4
Time in familiar zone, hab. session 10.20.20.6-0.10.2-0.7-0.6-0.20.4-0.4-0.5-0.40.2-0.6-0.3-0.5
Time in novel zone, hab. session 10.30.31.7-0.1-0.31.30.70.7-0.30.50.50.30.10.5-0.30.4
Total zone transitions, hab. session 13.44.88.1-1.3-1.6-2.0-2.4-2.52.8-1.5-2.0-2.82.5-2.7-1.81.7
Total locomotion distance, hab. session 12.94.16.9-1.6-2.0-1.7-1.9-2.42.5-1.4-1.9-2.42.3-2.6-1.31.8
Locomotion velocity, hab. session 13.04.27.8-1.6-1.9-1.6-1.9-2.62.6-1.4-1.8-2.52.2-2.8-1.31.7
Time in familiar zone, hab. session 20.80.93.60.2-0.4-1.9-0.7-1.50.7-0.5-0.3-0.50.6-0.6-0.41.9
Time in novel zone, hab. session 21.61.76.70.20.82.60.81.9-1.10.40.41.0-1.01.00.6-2.4
Total zone transitions, hab. session 21.31.64.7-0.4-0.9-1.2-0.8-1.11.60.3-0.2-1.51.5-1.2-1.72.2
Total locomotion distance, hab. session 22.93.87.8-0.9-1.6-1.8-1.7-2.22.5-0.6-1.1-2.32.3-2.4-1.62.8
Locomotion velocity, hab. session 23.64.88.7-1.3-1.9-2.1-1.9-2.52.8-0.7-1.3-2.62.6-2.7-1.53.0
Novel to familiar place preference ratio0.20.32.40.10.41.6-0.10.40.40.0-0.1-0.30.3-0.3-0.6-0.7
Novelty place preference0.30.32.8-0.10.21.7-0.10.40.40.0-0.1-0.30.3-0.3-0.6-0.6
Time in novel zone, NPP test0.30.43.6-0.10.21.90.10.70.20.10.0-0.00.1-0.0-0.4-0.7
Total zone transitions, NPP test1.92.84.8-1.6-1.9-0.7-1.7-1.82.2-1.2-1.5-2.11.9-2.0-1.01.3
Total locomotion distance, NPP test1.01.42.7-0.9-0.9-0.6-1.6-1.41.6-1.1-1.3-1.41.2-1.7-0.50.3
Locomotion velocity, NPP test1.52.24.2-0.9-1.0-1.1-2.0-1.81.9-1.2-1.4-1.71.6-2.0-0.80.8
Intraocular pressure0.20.41.00.50.3-0.21.00.6-0.40.90.70.5-0.80.50.0-0.3
Delta distance traveled before/after self-admin0.30.41.20.30.40.1-0.4-0.1-0.4-0.9-0.60.4-0.60.51.1-0.9
Delta ambulatory time before/after self-admin0.10.20.70.40.40.3-0.10.0-0.5-0.9-0.30.5-0.70.60.6-0.5
Parametrial fat weight3.07.011.93.23.0-0.33.22.6-2.83.53.42.6-2.52.8-1.70.1
Pavlov. Cond. lever latency3.03.79.63.12.8-0.71.11.6-2.51.51.82.4-2.02.2-0.4-0.3
Pavlov. Cond. magazine entry latency1.92.57.8-2.8-2.80.9-0.7-1.21.6-1.0-1.4-1.61.6-1.31.20.6
Pavlov. Cond. change in total contacts0.40.42.0-1.4-1.20.50.40.00.8-0.1-0.3-0.80.5-0.4-0.2-0.1
Pavlov. Cond. index score2.53.19.5-3.1-2.91.0-0.8-1.32.1-1.1-1.5-2.11.8-1.80.80.3
Pavlov. Cond. latency score2.32.98.9-3.0-2.81.0-0.7-1.32.0-1.0-1.4-2.01.7-1.80.70.4
Pavlov. Cond. lever contacts1.82.26.3-2.5-2.20.8-0.7-1.11.9-1.0-1.4-1.81.5-1.70.5-0.0
Pavlov. Cond. magazine entry number2.12.66.52.52.6-0.11.11.6-1.81.41.61.8-1.71.4-1.0-0.7
Pavlov. Cond. intertrial magazine entries0.80.93.51.11.50.5-0.31.0-0.8-0.10.10.9-1.20.80.2-1.9
Pavlov. Cond. lever-magazine prob. diff.2.63.29.4-3.1-2.80.8-0.8-1.42.2-1.0-1.5-2.21.8-1.90.60.3
Pavlov. Cond. response bias2.83.49.5-3.1-3.00.7-1.0-1.62.1-1.4-1.8-2.12.0-1.71.10.6
Pavlov. Cond. lever latency1.31.94.01.20.91.71.71.5-1.12.01.90.9-0.81.0-1.50.8
Pavlov. Cond. magazine entry latency0.60.92.7-0.20.11.00.80.7-0.90.40.51.1-1.21.11.6-1.3
Pavlov. Cond. change in total contacts0.40.92.2-0.7-0.4-1.5-1.0-1.20.5-1.3-1.2-0.2-0.0-0.41.5-0.8
Pavlov. Cond. index score0.40.63.1-0.9-0.6-0.6-0.5-0.60.2-0.9-0.80.0-0.2-0.11.8-1.1
Pavlov. Cond. latency score0.30.52.6-0.8-0.5-0.7-0.3-0.50.2-0.7-0.60.1-0.2-0.01.6-0.9
Pavlov. Cond. lever contacts1.01.53.4-0.9-0.6-1.6-1.6-1.41.0-1.9-1.8-0.80.6-0.91.3-0.8
Pavlov. Cond. magazine entry number0.40.51.4-0.3-0.50.1-0.4-0.30.7-0.1-0.3-1.01.1-0.8-1.21.1
Pavlov. Cond. intertrial magazine entries0.51.05.0-1.0-1.6-0.40.0-1.30.3-1.0-0.6-0.50.9-0.20.32.2
Pavlov. Cond. lever-magazine prob. diff.0.30.52.9-0.8-0.4-0.7-0.4-0.50.1-0.8-0.60.2-0.30.01.7-1.1
Pavlov. Cond. response bias0.71.02.8-1.2-0.9-0.5-1.0-0.90.6-1.4-1.4-0.40.2-0.51.7-1.2
Time in closed arm before self-admin0.10.21.0-0.2-0.0-0.3-0.40.1-0.1-0.7-0.60.1-0.10.11.0-0.4
Time in closed arm after self-admin0.30.41.3-0.10.20.6-0.80.10.4-0.8-1.0-0.40.2-0.4-0.0-1.1
Time in open arm before self-admin0.40.50.9-0.9-0.80.3-0.5-0.70.9-0.4-0.6-0.90.9-0.9-0.40.1
Time in open arm after self-admin0.20.30.6-0.8-0.8-0.1-0.4-0.70.4-0.5-0.3-0.40.6-0.50.30.5
Bone: periosteal estimation0.92.15.60.20.12.42.11.5-1.41.71.71.6-1.51.30.7-0.3
Bone: periosteal perimeter0.20.41.50.10.10.21.20.3-0.80.60.80.9-0.80.60.30.1
Bone: post-yield work0.30.51.7-0.2-0.11.00.7-0.1-0.40.20.20.7-1.30.41.2-0.8
Progressive ratio test 1 active lever presses0.20.32.0-0.30.4-0.0-0.40.10.1-0.2-0.1-0.20.10.31.4-1.3
Progressive ratio test 1 breakpoint0.20.42.0-0.40.3-0.0-0.60.00.2-0.4-0.2-0.40.20.11.4-1.3
Progressive ratio test 1 inactive lever presses0.20.51.21.01.1-0.60.50.1-0.31.01.00.1-0.30.4-0.8-0.1
Progressive ratio test 2 active lever presses0.10.10.2-0.30.00.2-0.3-0.30.5-0.0-0.0-0.50.3-0.30.4-0.5
Progressive ratio test 2 breakpoint0.10.10.3-0.30.00.1-0.4-0.40.5-0.1-0.1-0.50.4-0.30.4-0.5
Progressive ratio test 2 inactive lever presses0.20.52.4-1.0-0.60.9-0.3-0.00.7-0.2-0.4-0.50.6-0.51.6-0.6
Incentive Sensitization - Responses0.51.33.5-0.5-0.8-1.3-1.0-1.91.5-0.5-0.6-1.51.4-1.4-0.31.0
Incentive Sensitization - Breakpoint0.51.02.8-0.3-0.6-1.2-0.8-1.71.3-0.2-0.4-1.31.2-1.2-0.61.0
Sum of active levers in priming session hrs 5-60.20.20.5-0.5-0.3-0.1-0.4-0.60.2-0.7-0.6-0.30.2-0.5-0.0-0.2
Progressive ratio1.44.16.82.11.90.92.32.6-2.02.42.62.1-1.72.5-1.40.0
Food seeking constrained by brief footshock0.40.42.40.20.9-0.5-0.50.4-0.5-0.1-0.00.5-0.60.31.0-1.5
Seeking ratio, punishment vs. effort1.22.74.5-1.8-1.3-0.7-2.1-2.01.6-1.9-2.1-1.71.4-2.10.8-0.4
Retroperitoneal fat weight0.42.05.81.11.01.02.01.8-1.22.42.01.2-1.11.3-0.3-0.2
Reaction time number correct0.41.33.21.81.60.10.71.1-1.31.41.41.1-0.90.9-1.3-0.0
Reaction time mean minus median0.10.92.7-1.7-1.41.31.3-0.1-0.30.50.50.2-0.40.31.6-0.0
Reaction time mean minus median AUC0.21.35.9-1.6-1.01.81.10.2-0.60.20.30.5-0.80.62.4-1.2
Reaction time num false alarms0.50.92.6-0.8-1.2-1.50.2-0.91.00.4-0.2-0.71.0-0.70.61.6
Reaction time num false alarms AUC0.71.63.3-1.2-1.5-1.7-0.4-1.41.5-0.1-0.7-1.21.4-1.20.81.8
Reaction time trials correct on left0.41.33.21.81.60.10.71.1-1.31.41.41.1-0.90.9-1.3-0.0
Reaction time trials on left0.41.33.21.81.60.10.71.1-1.31.41.41.1-1.01.0-1.1-0.1
Reaction time mean0.40.93.6-0.7-0.31.00.90.2-0.8-0.00.31.0-1.30.71.9-1.1
Reaction time mean AUC0.51.33.9-0.5-0.11.21.30.5-1.20.30.61.3-1.61.02.0-1.4
Median of all reaction times0.50.82.8-0.10.20.60.70.3-0.9-0.10.21.2-1.50.71.7-1.3
Reaction time omissions0.30.51.4-0.3-0.6-0.31.2-0.0-0.60.70.70.6-0.40.51.10.8
Reaction time false alarm rate2.13.05.6-2.1-2.4-1.4-0.8-1.92.2-1.0-1.5-1.81.9-1.71.41.6
Reaction time premature initiation rate0.20.33.30.30.3-1.8-0.3-0.70.1-0.5-0.4-0.20.1-0.10.20.0
Reaction time premature initiations0.20.72.41.51.4-1.60.20.1-0.80.40.60.6-0.60.7-0.5-0.2
Std. dev. reaction times0.31.15.7-1.7-1.41.41.0-0.2-0.40.10.10.4-0.70.42.4-0.6
Reaction time trials completed0.41.33.21.81.60.10.71.1-1.31.41.41.1-1.01.0-1.1-0.1
Reaction time trials AUC0.41.43.41.81.60.10.71.1-1.41.41.51.2-1.01.0-1.2-0.0
Run reversals in cocaine runway, females0.40.43.10.10.8-0.0-0.5-0.1-0.1-0.7-0.4-0.1-0.60.40.9-1.8
Run reversals in cocaine runway, males0.70.83.3-1.5-1.41.80.80.80.20.6-0.1-0.30.4-0.00.60.1
Latency to leave start box in cocaine runway0.60.82.2-0.4-0.5-0.9-1.1-1.20.9-1.0-1.5-0.80.9-1.20.20.2
Latency to leave start box in cocaine runway, F0.40.51.0-0.2-0.3-0.4-1.0-1.00.6-0.8-1.0-0.60.6-1.00.20.1
Latency to leave start box in cocaine runway, M0.20.20.9-0.1-0.2-0.6-0.2-0.60.4-0.2-1.0-0.40.5-0.4-0.20.3
Std. dev. time between licks in bursts1.12.07.6-2.6-2.80.70.7-0.71.10.2-0.1-1.11.4-1.30.51.9
Total sessions with >9 infusions0.20.20.5-0.4-0.00.2-0.5-0.20.6-0.5-0.3-0.60.4-0.20.6-0.7
Short access day 1 total inactive lever presses0.20.42.5-1.0-0.51.60.30.40.1-0.3-0.3-0.0-0.30.20.5-1.0
Short access day 10 total inactive lever presses0.32.110.30.6-0.7-2.10.2-1.31.00.80.6-0.91.4-0.9-2.23.2
Short access day 1 total infusions0.30.72.3-0.8-0.4-0.3-0.9-0.60.9-0.9-0.6-1.00.7-0.61.5-0.8
Short access day 10 total infusions0.10.10.50.20.3-0.7-0.4-0.50.2-0.10.0-0.50.3-0.10.2-0.3
Short access total infusions0.20.31.4-0.30.2-0.1-0.5-0.40.4-0.6-0.4-0.50.1-0.10.8-1.2
Short access day 1 locomotion0.30.61.3-0.3-0.7-0.5-0.4-0.81.20.20.2-1.11.1-0.6-0.41.1
Short access day 10 total locomotion0.10.41.7-0.1-0.6-1.00.2-0.40.40.80.7-0.50.70.10.41.3
Short access total locomotion0.10.10.30.1-0.1-0.20.20.00.10.60.6-0.10.30.40.40.4
One hour access (0.3 mA shock)2.52.94.9-1.3-1.5-0.6-1.8-2.22.2-1.8-1.8-2.22.0-1.9-0.91.1
Compulsive drug intake1.21.84.3-0.1-0.9-0.9-1.2-2.01.1-1.8-1.2-1.11.0-1.1-2.11.7
One hour access (shock baseline)0.20.62.7-1.0-0.41.0-0.30.20.4-0.1-0.5-0.50.4-0.31.6-1.0
Social response proportion0.00.10.4-0.3-0.20.6-0.00.2-0.1-0.2-0.20.00.1-0.10.3-0.1
Social responses0.10.10.9-0.1-0.3-0.50.1-0.40.10.10.1-0.20.3-0.3-0.31.0
Social time0.81.28.0-0.9-1.60.10.6-1.10.60.10.1-0.61.1-0.5-0.92.8
Soleus weight1.13.215.5-2.7-2.63.91.91.1-0.20.70.70.20.40.22.40.4
Bone: stiffness0.50.91.91.31.1-0.30.80.5-0.71.01.00.7-1.30.7-1.40.0
Tibialis anterior weight0.30.92.2-0.1-0.3-1.4-1.2-1.40.7-1.5-1.3-0.60.8-0.7-0.10.7
Time to tail flick, vehicle, before self-admin1.72.15.41.0-0.10.22.20.6-1.22.22.21.1-0.40.7-1.82.3
Time to tail flick, vehicle, after self-admin0.10.21.0-0.1-0.20.2-0.6-0.60.2-1.0-1.0-0.20.2-0.2-0.5-0.0
Time to tail flick, test, before self-admin0.80.92.8-0.1-0.7-1.2-0.4-0.61.20.60.2-1.11.3-1.0-0.91.7
Time to tail flick, test, after self-admin0.40.41.4-0.9-1.21.10.1-0.20.5-0.1-0.4-0.40.5-0.2-0.10.6
Delta time to tail flick, vehicle, before/after SA1.92.15.7-0.60.3-0.1-2.4-0.80.9-2.4-2.4-0.90.3-0.71.3-2.2
Delta time to tail flick, test, before/after SA0.30.40.90.40.40.90.70.5-0.8-0.00.00.9-0.91.00.2-0.5
Tibia length1.74.811.40.80.42.83.42.4-2.52.82.82.4-2.12.30.10.2
Ambulatory time before self-admin0.20.51.70.3-0.1-0.60.70.30.01.31.2-0.10.30.1-1.01.0
Ambulatory time after self-admin0.20.41.10.70.3-0.40.70.5-0.50.71.10.5-0.30.7-0.30.7
Bone: tissue strength0.40.41.30.71.00.1-0.10.6-0.40.50.30.5-0.70.30.7-1.2
Total heroin consumption0.50.62.90.4-0.2-1.5-0.1-0.9-0.0-0.10.2-0.00.2-0.3-1.71.4
Bone: trabecular number0.30.61.6-0.0-0.0-1.0-1.2-1.00.4-1.2-1.2-0.60.4-0.3-0.2-0.3
Bone: trabecular spacing1.01.42.80.80.90.81.71.5-1.31.51.61.4-1.21.20.4-0.4
Bone: trabecular thickness0.40.51.40.40.41.20.60.9-0.80.70.50.7-0.80.80.1-0.8
Bone: trabecular tissue density0.20.41.3-1.1-0.91.10.20.30.50.40.0-0.50.4-0.50.6-0.1
Water consumed over 24 hours0.10.31.0-0.1-0.2-0.6-0.8-0.50.1-1.0-0.6-0.20.4-0.00.70.2
Number of responses in last shaping day1.92.45.7-2.4-1.50.7-1.4-0.92.0-1.7-1.8-1.71.5-1.71.1-0.7