Hub : Genes

Pou5f1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Pou5f1 0.05 0.03 1.6e-04 0.01 0.03 0.03 0.03 1.8e-02 1.8e-04 7.2e-04 9.4e-04
2 NAcc gene expression Pou5f1 0.04 0.02 3.4e-03 0.02 0.02 0.02 0.01 8.3e-04 1.2e-03 1.3e-03 1.9e-03
3 Brain gene expression Pou5f1 0.08 0.05 1.5e-03 0.02 0.03 0.04 0.03 2.3e-03 7.9e-04 2.4e-04 1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.30.61.1-0.6-0.71.0
Area under the delay curve0.61.01.9-0.21.41.0
BMI with tail1.24.37.2-2.72.30.5
BMI without tail1.26.611.7-2.83.40.1
Body weight1.77.516.8-2.44.1-0.4
Weight adjusted by age0.20.71.9-0.31.4-0.5
Bone surface0.10.20.40.30.20.6
Bone volume0.30.61.1-0.60.61.0
Breakpoint value in progressive ratio session0.20.30.40.6-0.6-0.5
Number of licking bursts0.51.53.61.9-0.80.5
Context. condit. distance diff. score5.97.211.43.0-3.40.9
Locomotion velocity, session 10.60.71.01.0-0.9-0.5
Locomotion distance, session 10.50.61.6-0.4-0.11.3
Locomotion velocity, session 20.30.40.50.7-0.40.7
Locomotion distance, session 20.30.40.70.3-0.50.8
Locomotion velocity, session 30.30.40.8-0.90.50.2
Locomotion distance, session 30.70.81.30.2-1.01.2
Stereotopy head waving bouts, day 30.30.40.50.70.70.0
Stereotopy head waving duration, day 30.30.40.60.30.7-0.8
Locomotion velocity, session 72.62.85.50.9-2.31.4
Locomotion distance, session 72.53.25.10.7-2.02.2
Stereotopy head waving bouts, day 71.11.32.9-0.31.70.9
Stereotopy head waving duration, day 70.91.12.9-0.51.70.5
Locomotion velocity, session 83.03.68.42.9-1.50.2
Locomotion distance, session 83.75.47.72.5-2.81.5
Degree of sensitization distance0.80.91.61.3-1.00.0
Degree of sensitization stereotypy0.91.01.5-0.31.21.2
Conditioned locomotion0.10.10.30.20.6-0.1
Cocaine response after cond. corrected0.71.02.40.5-0.71.6
Cocaine response after cond. not corrected0.30.40.90.9-0.20.5
Cocaine response before conditioning1.92.34.70.11.5-2.2
Saline control response3.34.56.2-2.52.1-1.7
Bone: connectivity density0.60.92.60.2-1.6-0.2
Bone: cortical apparent density0.91.43.3-1.81.00.1
Bone: cortical area0.61.01.9-0.41.41.0
Bone: cortical porosity0.50.50.9-0.10.81.0
Bone: cortical porosity0.20.20.20.50.40.4
Bone: cortical thickness3.96.57.6-2.62.82.3
Bone: cortical thickness2.12.55.4-2.31.50.2
Bone: cortical tissue density0.71.22.8-1.70.9-0.0
Condit. Reinf. active minus inactive responses0.40.51.10.4-1.1-0.4
Condit. Reinf. active-inactive response ratio0.20.20.3-0.60.2-0.5
Condit. Reinf. active responses0.60.81.30.2-1.1-1.0
Condit. Reinf. inactive responses0.30.41.0-0.3-1.0-0.5
Incentive salience index mean1.62.13.41.7-1.9-0.3
Condit. Reinf. lever presses3.04.67.02.6-2.6-0.3
Condit. Reinf. active minus inactive responses0.30.50.8-0.10.8-0.9
Condit. Reinf. active-inactive response ratio0.30.51.00.41.00.5
Condit. Reinf. active responses0.71.02.80.1-0.3-1.7
Condit. Reinf. inactive responses1.92.97.1-0.2-1.2-2.7
Condit. Reinf. lever presses1.11.63.60.4-1.0-1.9
Condit. Reinf. lever reinforcers received0.81.13.00.3-0.4-1.7
Conditioned reinforcement - actives0.83.36.0-1.11.72.5
Conditioned reinforcement - inactives1.23.25.4-1.11.72.3
Conditioned locomotion0.50.71.8-0.10.61.4
Patch foraging indifference point 0 sec1.13.04.0-2.01.0-2.0
Patch foraging indifference point AUC0.30.71.5-0.11.20.8
Delay disc. indifference point, 0s delay0.60.61.50.60.21.2
Delay disc. indifference point, 16s delay2.02.94.0-1.42.01.6
Delay disc. indifference point, 2s delay0.40.50.90.61.00.3
Delay disc. indifference point, 24s delay0.10.20.5-0.50.7-0.2
Delay disc. indifference point, 4s delay0.70.72.1-0.11.5-0.1
Delay disc. indifference point, 8s delay0.30.50.8-0.00.70.9
Indifference point function ln k0.41.11.91.2-1.4-0.0
Indifference point function log k0.41.11.91.2-1.4-0.0
Patch foraging total patch changes 0 sec1.13.34.8-2.21.2-1.9
Patch foraging total patch changes 12 sec1.52.03.0-1.71.5-0.9
Patch foraging total patch changes 18 sec1.22.86.3-2.51.0-1.1
Patch foraging total patch changes 24 sec0.41.43.7-1.90.70.3
Patch foraging total patch changes 6 sec1.93.34.8-2.21.7-1.5
Patch foraging time to switch 0 sec0.10.51.3-1.10.2-0.4
Patch foraging water rate 0 sec0.00.20.4-0.40.60.2
Patch foraging water rate 12 sec0.10.50.7-0.80.40.9
Patch foraging water rate 18 sec0.10.10.2-0.40.40.2
Patch foraging water rate 24 sec1.11.62.1-1.11.41.3
Patch foraging water rate 6 sec0.20.40.4-0.70.50.6
Seeking ratio, delayed vs. immediate footshock0.20.30.5-0.30.7-0.5
Distance traveled before self-admin0.00.10.20.50.20.1
Distance traveled after self-admin0.20.41.20.01.10.0
Extensor digitorum longus weight0.10.50.80.8-0.4-0.9
Bone: elastic displacement0.50.71.0-1.00.90.3
Bone: elastic work1.21.63.6-1.01.90.3
Bone: endosteal estimation1.84.38.82.00.2-3.0
Bone: endosteal perimeter1.94.67.92.8-1.4-2.0
Epididymis fat weight3.819.341.6-6.54.00.6
Delta time in closed arm before/after self-admin0.40.30.6-0.20.8-0.6
Delta time in open arm before/after self-admin0.20.20.4-0.6-0.00.6
Diff in mean of infusions in LGA sessions1.01.83.01.0-1.71.1
Delay discount exponential model param0.60.81.80.2-1.4-0.8
Extinction: sum of active levers before priming0.40.51.31.1-0.50.3
Active lever presses in extinction session 60.20.20.5-0.70.40.2
Bone: final force3.15.09.9-2.23.10.7
Bone: final moment2.74.38.4-2.02.90.6
Food consumed during 24 hour testing period0.10.10.20.30.2-0.4
Glucose4.16.512.43.5-2.6-0.5
Heart weight0.71.22.9-0.41.7-0.7
Delay discount hyperbolic model param0.60.81.90.2-1.4-0.7
Intermittent access intake day 1-15 change0.00.10.2-0.1-0.3-0.5
Intermittent access intake escalation0.10.30.8-0.90.2-0.4
Intermittent access intake escalation 20.30.51.00.4-0.7-1.0
Intermitt. access day 1 inactive lever presses0.10.92.01.40.20.9
Intermitt. access day 15 inactive lever presses0.10.40.8-0.30.9-0.5
Intermitt. access escalation Index0.72.24.11.5-2.00.6
Intermittent access day 1 total infusions0.72.15.9-0.40.32.4
Intermittent access day 15 total infusions0.51.22.2-1.00.51.5
Intermittent access terminal intake (last 3 days)0.81.42.3-1.01.01.5
Intermittent access total infusions1.61.94.6-0.80.72.1
Intermittent access day 1 locomotion0.20.41.1-0.4-0.01.1
Intermittent access day 15 total locomotion0.41.52.4-0.71.31.5
Intermittent access total locomotion1.21.42.3-0.91.01.5
Intermittent access standard deviation0.52.85.0-1.92.20.1
Left kidney weight1.18.817.0-3.04.1-0.9
Right kidney weight1.39.018.0-2.74.2-1.2
Cocaine induced anxiety0.41.01.61.2-1.30.2
Post-drug Anxiety1.11.21.60.7-1.3-1.2
Baseline Anxiety0.71.23.3-0.3-0.4-1.8
Tail length0.42.44.90.52.2-1.4
Length with tail0.73.26.70.32.6-1.7
Length without tail0.52.86.5-0.42.6-1.3
Times rat made contact with spout0.50.51.4-1.2-0.2-0.4
Lifetime Intake2.02.45.5-0.81.02.3
Liver weight, left0.91.52.71.6-0.4-1.3
Liver weight, right0.61.12.31.50.5-0.8
Locomotor activity1.72.77.00.9-0.4-2.7
Locomotor testing distance0.61.53.60.8-0.6-1.9
Locomotor testing rearing0.41.44.10.3-0.3-2.0
Locomotion in novel chamber0.30.40.8-0.40.90.5
Locomotion in novel chamber post-restriction0.41.11.6-1.11.3-0.8
Fecal boli incidents, locomotor time 10.10.30.5-0.1-0.5-0.7
Change in fecal boli incidents, locomotor task1.21.22.70.80.61.6
Time >=10cm from walls, locomotor time 10.30.40.60.70.3-0.8
Bouts of movement, locomotor time 11.21.52.90.8-1.7-1.0
Total resting periods, locomotor time 10.80.91.50.8-1.2-0.8
Rest time, locomotor task time 10.30.51.10.60.1-1.0
Distance moved, locomotor task time 10.31.01.5-0.71.21.0
Vertical activity count, locomotor time 10.10.40.8-0.90.5-0.2
Time >=10cm from walls, locomotor time 20.31.02.20.8-0.2-1.5
Bouts of movement, locomotor time 20.20.71.50.5-0.5-1.2
Total resting periods, locomotor time 20.31.21.91.0-0.8-1.4
Rest time, locomotor task time 21.42.43.81.9-1.4-1.3
Distance moved, locomotor task time 21.31.72.7-1.61.40.7
Vertical activity count, locomotor time 20.10.30.7-0.80.4-0.3
Light reinforcement 10.10.30.5-0.70.50.4
Light reinforcement 20.00.00.1-0.00.40.1
Bone: marrow area1.94.810.51.90.2-3.2
Bone: maximum diameter0.71.44.02.0-0.40.1
Bone: maximum force1.83.67.7-1.72.80.5
Bone: maximum moment1.52.96.2-1.52.50.4
Mean time between licks in bursts0.42.55.42.3-1.50.3
Mean num. licks in bursts0.82.25.6-2.40.6-0.9
Cd content in liver0.20.30.7-0.80.2-0.3
Co content in liver1.41.72.4-1.51.6-0.5
Cu content in liver0.40.50.8-0.9-0.70.5
Fe content in liver0.91.22.4-1.51.0-0.1
K content in liver0.70.71.9-0.0-0.31.4
Mg content in liver1.71.93.31.8-1.30.8
Mn content in liver4.55.17.32.7-2.5-1.3
Na content in liver1.21.42.6-0.71.01.6
Rb content in liver0.50.61.60.4-1.3-0.3
Se content in liver2.42.86.02.5-1.5-0.4
Sr content in liver0.30.30.70.10.3-0.8
Zn content in liver0.10.20.20.5-0.4-0.3
Bone: minimum diameter1.01.93.41.8-0.4-1.4
Time in familiar zone, hab. session 10.80.91.2-1.1-0.8-0.9
Time in novel zone, hab. session 10.30.30.90.90.4-0.2
Total zone transitions, hab. session 10.20.30.60.5-0.8-0.2
Total locomotion distance, hab. session 10.10.20.30.3-0.50.5
Locomotion velocity, hab. session 10.10.10.40.1-0.10.6
Time in familiar zone, hab. session 20.50.61.0-0.80.0-1.0
Time in novel zone, hab. session 20.10.10.20.10.30.5
Total zone transitions, hab. session 20.00.10.1-0.10.20.3
Total locomotion distance, hab. session 20.20.30.50.3-0.70.5
Locomotion velocity, hab. session 20.40.50.70.6-0.80.7
Novel to familiar place preference ratio0.40.51.3-0.10.41.1
Novelty place preference0.30.41.0-0.00.51.0
Time in novel zone, NPP test0.30.30.7-0.00.60.8
Total zone transitions, NPP test0.50.71.40.7-1.20.4
Total locomotion distance, NPP test0.40.51.10.1-0.71.0
Locomotion velocity, NPP test0.60.91.50.3-1.01.2
Intraocular pressure0.30.40.7-0.5-0.9-0.6
Delta distance traveled before/after self-admin0.91.02.3-0.71.50.6
Delta ambulatory time before/after self-admin0.20.41.0-0.21.00.3
Parametrial fat weight0.92.24.0-2.01.60.5
Pavlov. Cond. lever latency2.93.77.4-2.71.7-0.8
Pavlov. Cond. magazine entry latency2.63.45.72.4-2.1-0.3
Pavlov. Cond. change in total contacts0.60.71.81.3-0.20.5
Pavlov. Cond. index score3.64.58.52.9-2.20.3
Pavlov. Cond. latency score3.34.28.52.9-1.90.5
Pavlov. Cond. lever contacts2.73.26.92.6-1.50.6
Pavlov. Cond. magazine entry number2.93.65.1-2.12.21.1
Pavlov. Cond. intertrial magazine entries0.91.03.0-1.70.4-0.1
Pavlov. Cond. lever-magazine prob. diff.3.64.48.12.8-2.30.3
Pavlov. Cond. response bias3.34.16.72.6-2.3-0.3
Pavlov. Cond. lever latency0.40.51.10.50.41.1
Pavlov. Cond. magazine entry latency0.20.30.60.30.30.8
Pavlov. Cond. change in total contacts0.10.10.2-0.40.50.1
Pavlov. Cond. index score0.00.10.20.1-0.1-0.4
Pavlov. Cond. latency score0.10.10.2-0.20.1-0.5
Pavlov. Cond. lever contacts0.20.40.8-0.5-0.3-0.9
Pavlov. Cond. magazine entry number0.20.20.50.1-0.4-0.7
Pavlov. Cond. intertrial magazine entries1.02.22.71.7-1.6-1.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.0-0.2-0.5
Pavlov. Cond. response bias0.10.10.30.2-0.5-0.2
Time in closed arm before self-admin0.10.10.20.4-0.3-0.3
Time in closed arm after self-admin0.70.81.9-0.61.4-0.0
Time in open arm before self-admin0.50.61.10.8-1.0-0.3
Time in open arm after self-admin0.60.61.60.4-1.30.2
Bone: periosteal estimation0.61.42.40.91.0-1.6
Bone: periosteal perimeter0.30.61.81.30.1-0.3
Bone: post-yield work1.93.34.71.7-1.5-2.2
Progressive ratio test 1 active lever presses0.81.53.9-0.40.62.0
Progressive ratio test 1 breakpoint0.81.53.7-0.40.71.9
Progressive ratio test 1 inactive lever presses0.51.42.3-1.10.81.5
Progressive ratio test 2 active lever presses0.91.33.7-0.40.31.9
Progressive ratio test 2 breakpoint1.11.43.9-0.60.32.0
Progressive ratio test 2 inactive lever presses0.62.04.80.21.12.2
Incentive Sensitization - Responses0.00.10.30.2-0.20.5
Incentive Sensitization - Breakpoint0.10.10.40.1-0.20.6
Sum of active levers in priming session hrs 5-60.90.82.00.6-0.4-1.4
Progressive ratio1.85.210.6-2.13.3-0.8
Food seeking constrained by brief footshock0.10.10.2-0.3-0.1-0.4
Seeking ratio, punishment vs. effort1.73.97.81.9-2.80.6
Retroperitoneal fat weight0.31.41.7-1.31.21.1
Reaction time number correct0.41.53.2-1.81.0-0.5
Reaction time mean minus median0.42.33.61.9-1.8-0.1
Reaction time mean minus median AUC0.31.92.91.7-1.70.4
Reaction time num false alarms0.30.40.80.60.30.9
Reaction time num false alarms AUC0.30.71.20.70.61.1
Reaction time trials correct on left0.41.53.2-1.81.0-0.5
Reaction time trials on left0.41.43.0-1.71.0-0.5
Reaction time mean1.53.45.62.4-2.10.5
Reaction time mean AUC1.33.25.22.3-2.10.3
Median of all reaction times1.52.33.92.0-1.70.4
Reaction time omissions1.32.23.61.9-1.60.6
Reaction time false alarm rate1.11.63.11.8-0.11.2
Reaction time premature initiation rate0.71.12.8-0.61.70.1
Reaction time premature initiations0.82.54.9-1.62.2-0.2
Std. dev. reaction times0.92.95.52.4-1.70.5
Reaction time trials completed0.41.43.0-1.71.0-0.5
Reaction time trials AUC0.41.32.9-1.70.9-0.5
Run reversals in cocaine runway, females0.60.60.9-1.00.90.3
Run reversals in cocaine runway, males0.30.40.80.90.20.6
Latency to leave start box in cocaine runway0.30.41.01.0-0.40.1
Latency to leave start box in cocaine runway, F0.50.70.91.0-0.9-0.6
Latency to leave start box in cocaine runway, M0.60.60.80.10.90.9
Std. dev. time between licks in bursts1.42.66.52.6-1.1-0.3
Total sessions with >9 infusions1.62.04.0-0.71.32.0
Short access day 1 total inactive lever presses0.71.32.60.41.11.6
Short access day 10 total inactive lever presses0.10.61.50.6-0.31.2
Short access day 1 total infusions0.20.30.70.00.50.8
Short access day 10 total infusions1.42.34.9-0.81.12.2
Short access total infusions1.82.65.3-0.71.42.3
Short access day 1 locomotion0.81.43.20.7-0.61.8
Short access day 10 total locomotion0.10.30.60.80.4-0.4
Short access total locomotion0.50.82.00.50.41.4
One hour access (0.3 mA shock)0.70.91.90.6-0.61.4
Compulsive drug intake2.43.56.02.4-2.10.4
One hour access (shock baseline)0.41.12.2-1.50.90.6
Social response proportion0.50.61.40.7-0.1-1.2
Social responses0.10.10.20.40.4-0.4
Social time1.42.15.52.3-0.90.4
Soleus weight1.44.011.13.3-0.9-0.3
Bone: stiffness0.61.11.7-1.31.20.3
Tibialis anterior weight0.31.22.6-1.60.90.2
Time to tail flick, vehicle, before self-admin0.50.61.40.5-1.2-0.6
Time to tail flick, vehicle, after self-admin0.40.81.41.2-0.9-0.3
Time to tail flick, test, before self-admin0.10.10.2-0.2-0.3-0.4
Time to tail flick, test, after self-admin0.70.81.40.2-1.2-1.0
Delta time to tail flick, vehicle, before/after SA0.30.41.0-0.10.21.0
Delta time to tail flick, test, before/after SA0.10.10.2-0.3-0.5-0.2
Tibia length0.51.42.10.71.2-1.5
Ambulatory time before self-admin0.00.10.20.10.40.2
Ambulatory time after self-admin0.40.61.6-0.11.3-0.5
Bone: tissue strength2.22.34.7-1.22.20.8
Total heroin consumption0.10.10.30.40.0-0.5
Bone: trabecular number0.61.22.5-0.8-0.61.6
Bone: trabecular spacing0.60.92.60.31.6-0.3
Bone: trabecular thickness0.40.50.6-0.7-0.80.7
Bone: trabecular tissue density0.50.92.0-0.41.40.7
Water consumed over 24 hours0.10.10.30.5-0.1-0.1
Number of responses in last shaping day0.50.71.21.10.50.8