Hub : Genes

Polr1g

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Polr1g	0.04	0.04	6.0e-06	0.03	0.03	0.03	0.03	3.8e-05	4.2e-05	3.8e-05	6.6e-05
2	PL	gene expression	Polr1g	0.05	0.05	5.6e-05	0.03	0.04	0.02	0.03	5.4e-04	5.7e-05	3.2e-03	2.7e-04
3	Brain	gene expression	Polr1g	0.14	0.15	4.3e-06	0.05	0.06	0.06	0.06	9.9e-06	3.4e-06	7.6e-06	4.5e-06
4	BLA	gene expression	Polr1g	0.06	0.06	9.2e-03	0.02	0.02	0.02	0.02	3.8e-02	3.6e-02	4.6e-02	3.9e-02
5	LHb	gene expression	Polr1g	0.17	0.15	3.4e-03	0.1	0.08	0.11	0.09	2.2e-03	5.0e-03	1.6e-03	4.3e-03
6	Liver	gene expression	Polr1g	0.04	0.04	1.4e-04	0.03	0.03	0.03	0.03	2.2e-04	4.1e-04	4.7e-04	5.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.1	-0.1	0.1	0.2	-0.1	0.3	-0.1
Area under the delay curve	1.3	2.1	2.7	-1.4	1.4	1.4	1.5	-1.6	-1.3
BMI with tail	0.6	2.0	2.6	1.5	-1.3	-1.3	-1.4	1.6	1.3
BMI without tail	0.4	1.9	2.2	1.5	-1.4	-1.4	-1.3	1.3	1.5
Body weight	1.1	5.0	5.6	2.4	-2.2	-2.2	-2.2	2.3	2.2
Weight adjusted by age	0.0	0.0	0.0	0.1	-0.0	-0.1	0.0	-0.1	-0.0
Bone surface	0.2	0.5	1.0	0.7	-0.6	-0.5	-0.7	1.0	0.5
Bone volume	0.2	0.3	0.7	0.5	-0.5	-0.4	-0.6	0.9	0.4
Breakpoint value in progressive ratio session	1.5	2.7	3.0	-1.7	1.6	1.6	1.6	-1.6	-1.6
Number of licking bursts	1.3	3.9	4.8	2.2	-2.0	-2.1	-1.8	1.5	2.1
Context. condit. distance diff. score	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.4	0.4	0.5
Locomotion velocity, session 1	0.1	0.1	0.1	-0.3	0.2	0.2	0.3	-0.3	-0.1
Locomotion distance, session 1	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.2	0.3	0.0
Locomotion velocity, session 2	1.3	1.5	1.8	1.3	-1.3	-1.3	-1.2	1.0	1.3
Locomotion distance, session 2	0.3	0.4	0.6	0.6	-0.6	-0.5	-0.7	0.8	0.5
Locomotion velocity, session 3	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.5	0.4	0.5
Locomotion distance, session 3	0.8	0.9	0.9	-0.9	0.9	0.9	0.9	-1.0	-0.9
Stereotopy head waving bouts, day 3	0.9	1.1	1.6	1.1	-1.1	-1.2	-0.9	0.6	1.3
Stereotopy head waving duration, day 3	1.1	1.3	1.6	1.2	-1.2	-1.2	-1.1	0.9	1.3
Locomotion velocity, session 7	0.1	0.2	0.2	-0.4	0.4	0.5	0.3	-0.2	-0.5
Locomotion distance, session 7	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.2	0.3	0.0
Stereotopy head waving bouts, day 7	1.0	1.1	1.4	1.1	-1.1	-1.1	-1.0	1.0	1.2
Stereotopy head waving duration, day 7	0.8	1.0	1.2	1.0	-1.0	-1.0	-0.9	0.8	1.1
Locomotion velocity, session 8	0.0	0.0	0.0	-0.1	0.0	-0.0	0.1	-0.2	0.0
Locomotion distance, session 8	0.0	0.0	0.1	-0.0	-0.1	0.0	-0.2	0.3	0.1
Degree of sensitization distance	0.6	0.6	0.7	0.8	-0.8	-0.8	-0.8	0.8	0.8
Degree of sensitization stereotypy	1.0	1.2	1.3	1.1	-1.1	-1.1	-1.1	1.1	1.1
Conditioned locomotion	0.0	0.0	0.1	-0.2	0.2	0.2	0.2	-0.2	-0.3
Cocaine response after cond. corrected	0.5	0.7	1.0	0.9	-0.8	-0.8	-0.9	1.0	0.8
Cocaine response after cond. not corrected	1.3	1.8	2.4	1.4	-1.3	-1.3	-1.4	1.6	1.3
Cocaine response before conditioning	1.6	1.9	2.2	1.5	-1.4	-1.4	-1.4	1.3	1.3
Saline control response	2.0	2.8	3.0	1.7	-1.7	-1.7	-1.7	1.6	1.7
Bone: connectivity density	0.0	0.1	0.1	-0.2	0.3	0.4	0.1	0.2	-0.3
Bone: cortical apparent density	0.1	0.1	0.1	-0.4	0.3	0.4	0.3	-0.3	-0.2
Bone: cortical area	1.5	2.4	2.7	1.6	-1.6	-1.6	-1.6	1.5	1.4
Bone: cortical porosity	0.2	0.2	0.5	-0.4	0.4	0.3	0.5	-0.7	-0.3
Bone: cortical porosity	0.0	0.0	0.1	-0.0	0.0	-0.1	0.1	-0.3	0.1
Bone: cortical thickness	0.6	1.0	1.1	1.0	-1.0	-1.0	-1.0	1.0	0.9
Bone: cortical thickness	1.4	1.8	1.9	1.4	-1.3	-1.3	-1.3	1.4	1.3
Bone: cortical tissue density	0.1	0.2	0.2	-0.5	0.5	0.5	0.4	-0.5	-0.3
Condit. Reinf. active minus inactive responses	0.4	0.5	0.9	0.6	-0.6	-0.5	-0.7	0.9	0.7
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.9	0.5	-0.5	-0.4	-0.6	0.9	0.6
Condit. Reinf. active responses	0.3	0.3	0.8	0.5	-0.5	-0.4	-0.6	0.9	0.5
Condit. Reinf. inactive responses	0.0	0.1	0.1	-0.3	0.2	0.3	0.1	0.1	-0.3
Incentive salience index mean	0.2	0.3	0.6	0.5	-0.5	-0.4	-0.5	0.8	0.6
Condit. Reinf. lever presses	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1	0.3	0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.3	0.4	0.3
Condit. Reinf. active-inactive response ratio	0.3	0.5	0.8	0.7	-0.7	-0.6	-0.8	0.9	0.7
Condit. Reinf. active responses	0.1	0.1	0.1	-0.3	0.3	0.3	0.3	-0.3	-0.2
Condit. Reinf. inactive responses	0.6	0.9	1.0	-1.0	1.0	0.9	1.0	-1.0	-0.9
Condit. Reinf. lever presses	0.1	0.2	0.3	0.5	-0.4	-0.4	-0.5	0.5	0.4
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	-0.3	0.3	0.3	0.3	-0.3	-0.3
Conditioned reinforcement - actives	0.6	2.2	2.5	1.6	-1.5	-1.4	-1.5	1.6	1.4
Conditioned reinforcement - inactives	0.2	0.6	0.6	0.8	-0.8	-0.8	-0.7	0.7	0.8
Conditioned locomotion	2.1	3.1	3.4	1.8	-1.7	-1.7	-1.8	1.8	1.7
Patch foraging indifference point 0 sec	0.3	0.8	0.9	1.0	-0.9	-0.9	-0.9	0.8	0.9
Patch foraging indifference point AUC	1.8	4.2	4.8	2.2	-2.1	-2.2	-2.0	1.8	2.1
Delay disc. indifference point, 0s delay	1.4	1.5	1.7	-1.3	1.2	1.2	1.2	-1.3	-1.2
Delay disc. indifference point, 16s delay	0.9	1.3	1.5	-1.2	1.1	1.1	1.1	-1.2	-1.0
Delay disc. indifference point, 2s delay	3.7	4.1	5.7	-2.0	2.0	1.9	2.1	-2.4	-1.8
Delay disc. indifference point, 24s delay	0.0	0.1	0.1	0.3	-0.2	-0.2	-0.3	0.3	0.0
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	-0.0	0.0	-0.0	0.1	-0.2	-0.0
Delay disc. indifference point, 8s delay	1.2	2.0	2.4	-1.4	1.4	1.4	1.4	-1.6	-1.3
Indifference point function ln k	0.4	1.4	1.6	-1.3	1.2	1.2	1.1	-0.9	-1.2
Indifference point function log k	0.4	1.4	1.6	-1.3	1.2	1.2	1.1	-0.9	-1.2
Patch foraging total patch changes 0 sec	0.4	1.2	1.3	1.1	-1.1	-1.1	-1.1	1.1	1.0
Patch foraging total patch changes 12 sec	1.3	1.8	2.0	1.4	-1.3	-1.4	-1.3	1.2	1.3
Patch foraging total patch changes 18 sec	1.3	3.0	3.2	1.8	-1.7	-1.7	-1.7	1.7	1.6
Patch foraging total patch changes 24 sec	0.1	0.5	0.5	0.7	-0.7	-0.7	-0.7	0.7	0.6
Patch foraging total patch changes 6 sec	2.2	3.7	4.2	2.0	-1.9	-2.0	-1.9	1.8	1.9
Patch foraging time to switch 0 sec	1.4	5.5	6.4	-2.4	2.3	2.3	2.4	-2.5	-2.2
Patch foraging water rate 0 sec	1.6	6.2	6.7	2.6	-2.5	-2.5	-2.5	2.5	2.4
Patch foraging water rate 12 sec	0.1	0.3	0.4	0.5	-0.5	-0.4	-0.6	0.6	0.4
Patch foraging water rate 18 sec	0.1	0.2	0.2	0.4	-0.4	-0.4	-0.5	0.5	0.3
Patch foraging water rate 24 sec	0.6	0.8	0.9	1.0	-0.9	-0.9	-0.9	1.0	0.8
Patch foraging water rate 6 sec	0.7	1.0	1.3	1.0	-1.0	-0.9	-1.0	1.1	0.9
Seeking ratio, delayed vs. immediate footshock	1.7	2.4	2.8	-1.7	1.6	1.6	1.5	-1.4	-1.5
Distance traveled before self-admin	0.0	0.1	0.2	0.4	-0.3	-0.3	-0.3	0.3	0.3
Distance traveled after self-admin	0.1	0.2	0.2	-0.4	0.4	0.4	0.4	-0.4	-0.5
Extensor digitorum longus weight	1.8	7.1	7.3	2.7	-2.7	-2.6	-2.7	2.7	2.6
Bone: elastic displacement	0.9	1.2	1.7	-1.3	1.1	1.1	1.1	-0.9	-0.9
Bone: elastic work	0.0	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.2	0.1
Bone: endosteal estimation	0.0	0.1	0.1	-0.3	0.2	0.3	0.2	-0.0	-0.3
Bone: endosteal perimeter	0.0	0.0	0.0	-0.0	0.0	0.0	0.0	0.1	-0.0
Epididymis fat weight	0.2	0.8	1.0	-0.9	0.9	0.9	1.0	-1.0	-0.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.3	0.3	0.3	0.3	-0.2	-0.3
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.1	0.2	0.2	0.2	-0.2	-0.2
Diff in mean of infusions in LGA sessions	0.9	1.7	1.8	-1.3	1.3	1.3	1.3	-1.3	-1.3
Delay discount exponential model param	1.1	1.5	2.0	1.2	-1.2	-1.1	-1.2	1.4	1.1
Extinction: sum of active levers before priming	0.0	0.1	0.1	-0.3	0.3	0.2	0.3	-0.2	-0.2
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.2	0.2	0.2
Bone: final force	0.4	0.6	0.7	0.8	-0.8	-0.8	-0.8	0.8	0.7
Bone: final moment	0.5	0.9	1.0	1.0	-0.9	-0.9	-0.9	0.9	0.8
Food consumed during 24 hour testing period	3.5	7.1	7.8	-2.8	2.7	2.7	2.6	-2.4	-2.7
Glucose	0.3	0.4	0.7	-0.6	0.6	0.5	0.7	-0.9	-0.5
Heart weight	2.2	3.5	4.1	2.0	-1.9	-1.9	-1.8	1.7	1.8
Delay discount hyperbolic model param	1.0	1.3	1.9	1.1	-1.1	-1.1	-1.2	1.4	1.0
Intermittent access intake day 1-15 change	0.0	0.1	0.2	0.4	-0.4	-0.4	-0.4	0.4	0.3
Intermittent access intake escalation	0.0	0.2	0.3	0.5	-0.5	-0.5	-0.5	0.5	0.4
Intermittent access intake escalation 2	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	0.0
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.0	0.0
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.0	0.0
Intermitt. access escalation Index	0.1	0.3	0.4	-0.6	0.5	0.6	0.5	-0.5	-0.5
Intermittent access day 1 total infusions	0.8	2.3	2.5	1.6	-1.5	-1.5	-1.5	1.5	1.5
Intermittent access day 15 total infusions	0.4	1.1	1.2	1.1	-1.0	-1.1	-1.0	1.0	1.0
Intermittent access terminal intake (last 3 days)	0.9	1.5	1.7	1.3	-1.2	-1.2	-1.2	1.2	1.1
Intermittent access total infusions	2.5	2.9	3.3	1.8	-1.7	-1.7	-1.7	1.7	1.7
Intermittent access day 1 locomotion	0.2	0.4	0.4	0.6	-0.6	-0.6	-0.6	0.6	0.6
Intermittent access day 15 total locomotion	0.1	0.2	0.3	0.5	-0.5	-0.5	-0.5	0.4	0.5
Intermittent access total locomotion	1.6	2.0	2.2	1.5	-1.4	-1.4	-1.4	1.4	1.4
Intermittent access standard deviation	0.0	0.2	0.3	-0.5	0.4	0.4	0.5	-0.5	-0.5
Left kidney weight	3.3	26.3	28.9	5.4	-5.0	-4.9	-5.2	5.3	4.9
Right kidney weight	3.4	23.8	26.2	5.1	-4.8	-4.7	-4.9	5.0	4.7
Cocaine induced anxiety	0.1	0.3	0.4	-0.6	0.5	0.5	0.6	-0.6	-0.4
Post-drug Anxiety	0.0	0.0	0.1	-0.3	0.2	0.2	0.2	-0.3	-0.1
Baseline Anxiety	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.0	0.0
Tail length	0.2	1.3	1.5	1.2	-1.2	-1.2	-1.1	0.9	1.2
Length with tail	0.3	1.4	1.6	1.3	-1.2	-1.2	-1.2	1.1	1.1
Length without tail	0.2	1.2	1.9	1.1	-1.0	-0.9	-1.1	1.4	0.9
Times rat made contact with spout	0.0	0.0	0.0	-0.1	0.1	0.2	-0.0	0.2	-0.1
Lifetime Intake	2.3	2.9	3.2	1.8	-1.7	-1.7	-1.7	1.6	1.7
Liver weight, left	2.0	3.5	3.8	2.0	-1.9	-1.9	-1.8	1.7	2.0
Liver weight, right	1.3	2.2	2.5	1.5	-1.4	-1.4	-1.5	1.6	1.5
Locomotor activity	2.2	3.5	4.2	2.1	-1.9	-2.0	-1.8	1.5	1.9
Locomotor testing distance	0.9	2.1	2.5	1.6	-1.5	-1.6	-1.4	1.1	1.5
Locomotor testing rearing	2.4	8.9	10.0	3.2	-3.0	-3.0	-2.9	2.8	3.0
Locomotion in novel chamber	0.1	0.2	0.3	-0.3	0.4	0.4	0.4	-0.4	-0.6
Locomotion in novel chamber post-restriction	0.4	1.4	1.8	-1.3	1.2	1.1	1.2	-1.2	-1.0
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.2	0.1	0.3
Change in fecal boli incidents, locomotor task	0.8	0.9	1.0	-0.9	0.9	0.9	0.9	-1.0	-0.9
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.0	0.1	0.1	-0.0	0.3	-0.1
Bouts of movement, locomotor time 1	2.1	2.7	3.1	-1.7	1.7	1.7	1.6	-1.4	-1.8
Total resting periods, locomotor time 1	3.0	3.5	4.0	-1.9	1.9	1.9	1.8	-1.7	-2.0
Rest time, locomotor task time 1	0.1	0.2	0.4	-0.5	0.5	0.5	0.4	-0.3	-0.6
Distance moved, locomotor task time 1	0.2	0.5	0.7	0.7	-0.7	-0.8	-0.7	0.5	0.8
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.0	0.1	0.0	0.1	-0.3	-0.0
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	-0.3	0.3	0.2	0.3	-0.5	-0.2
Bouts of movement, locomotor time 2	2.1	7.1	7.7	-2.8	2.7	2.7	2.6	-2.5	-2.7
Total resting periods, locomotor time 2	1.6	6.3	6.8	-2.6	2.5	2.6	2.4	-2.3	-2.6
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.2	0.2	0.3	0.1	0.2	-0.3
Distance moved, locomotor task time 2	0.7	0.9	1.2	1.0	-1.0	-1.0	-0.9	0.6	1.1
Vertical activity count, locomotor time 2	0.1	0.1	0.4	-0.3	0.3	0.2	0.4	-0.7	-0.2
Light reinforcement 1	0.0	0.1	0.2	0.3	-0.3	-0.3	-0.4	0.4	0.3
Light reinforcement 2	0.0	0.1	0.1	0.3	-0.3	-0.3	-0.3	0.2	0.2
Bone: marrow area	0.0	0.0	0.1	-0.3	0.2	0.2	0.1	0.0	-0.2
Bone: maximum diameter	2.1	4.3	4.6	2.1	-2.1	-2.1	-2.1	2.1	2.0
Bone: maximum force	0.1	0.3	0.3	0.6	-0.5	-0.5	-0.5	0.5	0.4
Bone: maximum moment	0.2	0.4	0.5	0.7	-0.6	-0.6	-0.6	0.6	0.5
Mean time between licks in bursts	0.0	0.1	0.1	-0.3	0.3	0.3	0.3	-0.4	-0.3
Mean num. licks in bursts	1.5	3.9	4.9	-2.2	2.1	2.2	1.8	-1.3	-2.2
Cd content in liver	0.1	0.1	0.1	-0.2	0.2	0.3	0.1	0.2	-0.3
Co content in liver	1.3	1.5	1.6	-1.2	1.2	1.2	1.2	-1.2	-1.2
Cu content in liver	0.3	0.4	0.4	0.7	-0.6	-0.7	-0.6	0.5	0.6
Fe content in liver	4.9	6.0	7.2	2.7	-2.5	-2.6	-2.4	1.9	2.6
K content in liver	0.1	0.1	0.2	0.4	-0.4	-0.5	-0.3	0.2	0.4
Mg content in liver	0.5	0.5	0.7	0.8	-0.7	-0.8	-0.7	0.5	0.8
Mn content in liver	0.9	1.1	1.2	1.1	-1.0	-1.0	-1.0	1.1	1.0
Na content in liver	0.2	0.2	0.3	0.5	-0.5	-0.6	-0.4	0.2	0.4
Rb content in liver	0.1	0.2	0.5	0.3	-0.3	-0.2	-0.4	0.7	0.2
Se content in liver	3.7	4.3	5.2	2.3	-2.1	-2.2	-2.0	1.5	2.2
Sr content in liver	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.1	-0.2	0.2
Zn content in liver	0.7	0.9	0.9	0.9	-0.9	-0.9	-0.9	1.0	0.9
Bone: minimum diameter	0.2	0.3	0.3	0.5	-0.6	-0.6	-0.6	0.5	0.5
Time in familiar zone, hab. session 1	0.2	0.2	0.2	0.5	-0.4	-0.5	-0.4	0.4	0.5
Time in novel zone, hab. session 1	0.5	0.6	0.6	0.8	-0.8	-0.8	-0.7	0.7	0.7
Total zone transitions, hab. session 1	0.2	0.2	0.4	0.5	-0.5	-0.4	-0.5	0.6	0.4
Total locomotion distance, hab. session 1	0.4	0.6	0.7	-0.8	0.7	0.7	0.7	-0.8	-0.7
Locomotion velocity, hab. session 1	1.2	1.8	1.9	-1.4	1.3	1.3	1.3	-1.4	-1.3
Time in familiar zone, hab. session 2	0.2	0.3	0.4	0.6	-0.5	-0.6	-0.4	0.2	0.7
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.2	0.2	0.2	0.1	0.1	-0.3
Total zone transitions, hab. session 2	0.5	0.6	0.8	0.9	-0.8	-0.9	-0.8	0.6	0.8
Total locomotion distance, hab. session 2	0.5	0.7	0.9	-0.9	0.8	0.8	0.9	-1.0	-0.7
Locomotion velocity, hab. session 2	0.3	0.5	0.6	-0.7	0.7	0.6	0.7	-0.8	-0.6
Novel to familiar place preference ratio	0.6	0.8	1.9	0.8	-0.8	-0.7	-1.0	1.4	0.6
Novelty place preference	0.6	0.7	1.7	0.7	-0.8	-0.6	-0.9	1.3	0.6
Time in novel zone, NPP test	0.7	0.9	1.9	0.8	-0.9	-0.8	-1.0	1.4	0.7
Total zone transitions, NPP test	0.1	0.2	0.2	0.4	-0.4	-0.4	-0.4	0.3	0.3
Total locomotion distance, NPP test	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.4	0.3	0.3
Locomotion velocity, NPP test	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3	0.3	0.3
Intraocular pressure	0.0	0.0	0.0	-0.0	0.0	0.1	0.0	0.1	-0.0
Delta distance traveled before/after self-admin	1.9	2.1	2.4	-1.5	1.4	1.4	1.4	-1.4	-1.4
Delta ambulatory time before/after self-admin	0.3	0.5	0.6	-0.8	0.7	0.7	0.7	-0.7	-0.7
Parametrial fat weight	0.1	0.1	0.1	0.4	-0.4	-0.4	-0.4	0.4	0.4
Pavlov. Cond. lever latency	0.5	0.7	1.0	-0.7	0.8	0.7	0.8	-1.0	-0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.2	-0.2	-0.2	-0.3	0.5	0.4
Pavlov. Cond. change in total contacts	0.6	0.6	0.8	-0.9	0.8	0.9	0.7	-0.5	-0.8
Pavlov. Cond. index score	0.3	0.3	0.5	0.5	-0.5	-0.5	-0.5	0.7	0.6
Pavlov. Cond. latency score	0.1	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.4	0.3
Pavlov. Cond. lever contacts	0.3	0.4	0.6	0.5	-0.6	-0.5	-0.6	0.8	0.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.1	0.1	0.0	0.1	-0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.3	0.4	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	0.6	-0.6	-0.5	-0.6	0.7	0.6
Pavlov. Cond. response bias	0.9	1.1	1.6	1.0	-1.0	-0.9	-1.0	1.3	1.1
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.2	0.1	0.2	0.1	-0.2	-0.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.5	0.1	-0.1	0.0	-0.3	0.7	0.0
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	-0.5	0.5	0.5	0.4	-0.2	-0.6
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	0.1	0.2	0.0	0.2	-0.2
Pavlov. Cond. latency score	0.0	0.1	0.1	-0.2	0.3	0.3	0.2	0.1	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.3	0.4	0.3
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	0.6	-0.6	-0.7	-0.5	0.1	0.7
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.0	-0.1	-0.1	-0.0	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.2	0.1	-0.0	0.0	-0.1	0.4	-0.0
Pavlov. Cond. response bias	0.0	0.0	0.1	0.0	0.0	0.1	-0.0	0.3	-0.1
Time in closed arm before self-admin	0.6	1.1	1.3	1.1	-1.0	-1.0	-1.1	1.1	0.9
Time in closed arm after self-admin	0.7	0.8	0.9	-0.9	0.9	0.9	0.9	-0.9	-0.9
Time in open arm before self-admin	0.8	0.9	1.2	-1.1	1.0	0.9	1.0	-1.0	-0.8
Time in open arm after self-admin	0.1	0.1	0.2	-0.4	0.4	0.3	0.4	-0.4	-0.3
Bone: periosteal estimation	0.2	0.5	0.7	0.7	-0.7	-0.7	-0.7	0.8	0.6
Bone: periosteal perimeter	0.2	0.4	0.5	0.7	-0.7	-0.7	-0.7	0.7	0.6
Bone: post-yield work	0.6	1.1	1.3	-1.1	1.1	1.1	1.0	-1.0	-1.1
Progressive ratio test 1 active lever presses	1.8	3.2	3.5	1.9	-1.8	-1.8	-1.8	1.7	1.8
Progressive ratio test 1 breakpoint	1.6	2.8	3.1	1.8	-1.7	-1.7	-1.7	1.6	1.6
Progressive ratio test 1 inactive lever presses	0.7	1.8	2.0	1.4	-1.4	-1.4	-1.3	1.3	1.3
Progressive ratio test 2 active lever presses	1.8	2.6	2.8	1.7	-1.6	-1.6	-1.6	1.5	1.7
Progressive ratio test 2 breakpoint	2.3	2.9	3.1	1.8	-1.7	-1.7	-1.7	1.6	1.8
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	0.4	-0.4	-0.5	-0.4	0.3	0.5
Incentive Sensitization - Responses	0.6	1.6	1.7	1.3	-1.3	-1.3	-1.2	1.2	1.3
Incentive Sensitization - Breakpoint	0.6	1.4	1.5	1.2	-1.2	-1.2	-1.1	1.1	1.2
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.3	-0.5	0.5	0.5	0.5	-0.5	-0.5
Progressive ratio	0.6	1.7	2.1	-1.5	1.3	1.3	1.3	-1.4	-1.1
Food seeking constrained by brief footshock	5.3	6.6	7.0	-2.6	2.6	2.6	2.5	-2.4	-2.6
Seeking ratio, punishment vs. effort	0.4	0.8	1.3	-0.9	0.9	0.9	0.8	-0.7	-1.1
Retroperitoneal fat weight	0.0	0.1	0.1	0.4	-0.3	-0.3	-0.3	0.3	0.3
Reaction time number correct	2.1	7.6	8.4	2.9	-2.8	-2.8	-2.8	2.7	2.7
Reaction time mean minus median	0.0	0.1	0.2	-0.3	0.3	0.4	0.3	0.0	-0.5
Reaction time mean minus median AUC	0.0	0.2	0.7	0.5	-0.4	-0.3	-0.5	0.8	0.2
Reaction time num false alarms	3.6	6.0	6.5	2.6	-2.4	-2.4	-2.5	2.5	2.4
Reaction time num false alarms AUC	2.2	5.1	5.6	2.4	-2.3	-2.2	-2.3	2.2	2.3
Reaction time trials correct on left	2.1	7.6	8.4	2.9	-2.8	-2.8	-2.8	2.7	2.7
Reaction time trials on left	2.2	7.6	8.4	2.9	-2.8	-2.8	-2.8	2.7	2.7
Reaction time mean	0.8	1.8	2.2	-1.4	1.4	1.5	1.3	-0.9	-1.5
Reaction time mean AUC	0.6	1.3	1.7	-1.2	1.2	1.3	1.1	-0.8	-1.3
Median of all reaction times	1.4	2.2	2.6	-1.6	1.5	1.6	1.4	-1.2	-1.6
Reaction time omissions	0.0	0.0	0.2	0.0	-0.0	0.1	-0.1	0.4	-0.1
Reaction time false alarm rate	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.4	0.4	0.4
Reaction time premature initiation rate	0.4	0.6	0.8	-0.9	0.8	0.8	0.7	-0.5	-0.8
Reaction time premature initiations	0.1	0.5	0.8	0.6	-0.6	-0.6	-0.7	0.9	0.6
Std. dev. reaction times	0.1	0.3	0.4	-0.5	0.5	0.6	0.5	-0.3	-0.7
Reaction time trials completed	2.2	7.6	8.4	2.9	-2.8	-2.8	-2.8	2.7	2.7
Reaction time trials AUC	2.6	9.2	10.1	3.2	-3.0	-3.0	-3.0	3.0	3.0
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.5	0.5	0.5	0.5	-0.6	-0.6
Run reversals in cocaine runway, males	0.4	0.5	0.5	0.7	-0.7	-0.7	-0.7	0.7	0.7
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.3	-0.3	-0.2	-0.4	0.5	0.1
Latency to leave start box in cocaine runway, F	0.7	0.9	0.9	1.0	-0.9	-0.9	-1.0	1.0	0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.4	0.4	0.4	0.3	-0.1	-0.4
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.0	-0.1	0.0	-0.2	0.3	0.1
Total sessions with >9 infusions	3.7	4.6	5.2	2.3	-2.2	-2.2	-2.1	2.0	2.1
Short access day 1 total inactive lever presses	0.3	0.6	0.6	0.8	-0.8	-0.8	-0.8	0.7	0.8
Short access day 10 total inactive lever presses	0.2	1.4	1.6	-1.3	1.2	1.2	1.2	-1.2	-1.2
Short access day 1 total infusions	1.3	2.6	2.8	1.7	-1.6	-1.6	-1.6	1.5	1.6
Short access day 10 total infusions	2.8	4.6	5.1	2.3	-2.1	-2.1	-2.1	2.1	2.1
Short access total infusions	2.0	2.8	3.0	1.7	-1.7	-1.7	-1.6	1.6	1.7
Short access day 1 locomotion	2.4	4.0	4.4	2.1	-2.0	-2.0	-2.0	1.9	2.0
Short access day 10 total locomotion	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.2	-0.0
Short access total locomotion	0.6	0.9	1.1	1.0	-1.0	-0.9	-1.0	1.0	0.9
One hour access (0.3 mA shock)	0.0	0.0	0.0	0.2	-0.2	-0.2	-0.2	0.2	0.1
Compulsive drug intake	0.2	0.3	0.5	0.6	-0.5	-0.5	-0.6	0.7	0.4
One hour access (shock baseline)	0.5	1.3	1.4	1.2	-1.1	-1.1	-1.1	1.0	1.1
Social response proportion	1.0	1.3	2.1	1.1	-1.1	-1.0	-1.2	1.4	0.9
Social responses	0.9	1.1	1.4	1.1	-1.0	-1.0	-1.1	1.2	1.0
Social time	2.8	4.4	4.8	-2.2	2.1	2.1	2.1	-2.0	-2.2
Soleus weight	0.1	0.4	0.6	0.6	-0.6	-0.6	-0.6	0.8	0.5
Bone: stiffness	0.7	1.2	1.6	1.3	-1.1	-1.2	-1.1	1.0	1.0
Tibialis anterior weight	3.3	11.3	12.3	3.4	-3.3	-3.3	-3.4	3.5	3.2
Time to tail flick, vehicle, before self-admin	2.5	3.1	3.3	1.8	-1.8	-1.8	-1.7	1.7	1.8
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1	0.1	0.2
Time to tail flick, test, before self-admin	0.4	0.5	0.5	-0.7	0.7	0.7	0.7	-0.7	-0.6
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.5	0.4	0.4	0.5	-0.5	-0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.3	0.3	0.3	0.3	-0.3	-0.3
Delta time to tail flick, test, before/after SA	0.7	0.8	0.9	1.0	-0.9	-0.9	-0.9	0.9	0.9
Tibia length	0.2	0.6	0.8	0.9	-0.7	-0.7	-0.8	0.9	0.8
Ambulatory time before self-admin	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.0	-0.1
Ambulatory time after self-admin	0.3	0.5	0.5	-0.7	0.7	0.7	0.7	-0.7	-0.7
Bone: tissue strength	0.8	0.8	1.0	-1.0	0.9	0.9	0.9	-0.8	-1.0
Total heroin consumption	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	-0.1	-0.1
Bone: trabecular number	0.0	0.1	0.2	-0.3	0.3	0.4	0.2	0.0	-0.3
Bone: trabecular spacing	0.0	0.1	0.1	0.2	-0.3	-0.3	-0.2	0.2	0.3
Bone: trabecular thickness	1.3	1.7	2.0	1.4	-1.3	-1.2	-1.4	1.4	1.2
Bone: trabecular tissue density	0.3	0.5	0.6	0.8	-0.7	-0.7	-0.7	0.6	0.8
Water consumed over 24 hours	0.1	0.2	0.3	-0.5	0.4	0.5	0.3	-0.1	-0.5
Number of responses in last shaping day	2.6	3.4	3.8	1.9	-1.8	-1.8	-1.8	1.8	1.8