Hub : Genes

Polr1g

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Polr1g 0.04 0.04 6.0e-06 0.03 0.03 0.03 0.03 3.8e-05 4.2e-05 3.8e-05 6.3e-05
2 PL gene expression Polr1g 0.05 0.05 5.6e-05 0.03 0.04 0.02 0.03 5.4e-04 5.7e-05 3.2e-03 2.6e-04
3 Brain gene expression Polr1g 0.14 0.15 4.3e-06 0.05 0.06 0.06 0.06 9.9e-06 3.4e-06 7.7e-06 4.6e-06
4 BLA gene expression Polr1g 0.06 0.06 9.2e-03 0.02 0.02 0.02 0.02 3.8e-02 3.6e-02 4.6e-02 4.0e-02
5 LHb gene expression Polr1g 0.17 0.15 3.4e-03 0.1 0.08 0.11 0.09 2.2e-03 5.0e-03 1.6e-03 3.6e-03
6 Liver gene expression Polr1g 0.04 0.04 1.4e-04 0.03 0.03 0.03 0.03 2.2e-04 4.1e-04 4.7e-04 6.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density0.00.00.10.10.10.2-0.1-0.30.1
Area under the delay curve1.82.12.71.41.41.41.51.61.3
BMI with tail0.62.02.6-1.5-1.3-1.3-1.4-1.6-1.3
BMI without tail0.61.92.2-1.5-1.4-1.4-1.3-1.3-1.5
Body weight1.15.05.6-2.4-2.2-2.2-2.2-2.3-2.2
Weight adjusted by age0.00.00.0-0.1-0.0-0.10.00.10.0
Bone surface0.30.51.0-0.7-0.6-0.5-0.7-1.0-0.5
Bone volume0.20.30.7-0.5-0.5-0.4-0.6-0.9-0.4
Breakpoint value in progressive ratio session2.32.73.01.71.61.61.61.61.6
Number of licking bursts2.43.94.8-2.2-2.0-2.1-1.8-1.5-2.1
Context. condit. distance diff. score0.10.10.2-0.4-0.4-0.4-0.4-0.4-0.5
Locomotion velocity, session 10.10.10.10.30.20.20.30.30.1
Locomotion distance, session 10.00.00.1-0.1-0.2-0.1-0.2-0.3-0.0
Locomotion velocity, session 21.31.51.8-1.3-1.3-1.3-1.2-1.0-1.3
Locomotion distance, session 20.30.40.6-0.6-0.6-0.5-0.7-0.8-0.5
Locomotion velocity, session 30.20.20.3-0.5-0.5-0.5-0.5-0.4-0.5
Locomotion distance, session 30.80.90.90.90.90.90.91.00.9
Stereotopy head waving bouts, day 30.91.11.6-1.1-1.1-1.2-0.9-0.6-1.3
Stereotopy head waving duration, day 31.11.31.6-1.2-1.2-1.2-1.1-0.9-1.3
Locomotion velocity, session 70.10.20.20.40.40.50.30.20.5
Locomotion distance, session 70.00.00.1-0.2-0.2-0.1-0.2-0.3-0.0
Stereotopy head waving bouts, day 71.01.11.4-1.1-1.1-1.1-1.0-1.0-1.2
Stereotopy head waving duration, day 70.81.01.2-1.0-1.0-1.0-0.9-0.8-1.1
Locomotion velocity, session 80.00.00.00.10.0-0.00.10.2-0.0
Locomotion distance, session 80.00.00.10.0-0.10.0-0.2-0.3-0.1
Degree of sensitization distance0.60.60.7-0.8-0.8-0.8-0.8-0.8-0.8
Degree of sensitization stereotypy1.11.21.3-1.1-1.1-1.1-1.1-1.1-1.1
Conditioned locomotion0.00.00.10.20.20.20.20.20.3
Cocaine response after cond. corrected0.60.71.0-0.9-0.8-0.8-0.9-1.0-0.8
Cocaine response after cond. not corrected1.61.82.4-1.4-1.3-1.3-1.4-1.6-1.3
Cocaine response before conditioning1.61.92.2-1.5-1.4-1.4-1.4-1.3-1.3
Saline control response2.12.83.0-1.7-1.7-1.7-1.7-1.6-1.7
Bone: connectivity density0.00.10.10.20.30.40.1-0.20.3
Bone: cortical apparent density0.10.10.10.40.30.40.30.30.2
Bone: cortical area1.62.42.7-1.6-1.6-1.6-1.6-1.5-1.4
Bone: cortical porosity0.20.20.50.40.40.30.50.70.3
Bone: cortical porosity0.00.00.10.00.0-0.10.10.3-0.1
Bone: cortical thickness0.61.01.1-1.0-1.0-1.0-1.0-1.0-0.9
Bone: cortical thickness1.51.81.9-1.4-1.3-1.3-1.3-1.4-1.3
Bone: cortical tissue density0.10.20.20.50.50.50.40.50.3
Condit. Reinf. active minus inactive responses0.40.50.9-0.6-0.6-0.5-0.7-0.9-0.7
Condit. Reinf. active-inactive response ratio0.30.40.9-0.5-0.5-0.4-0.6-0.9-0.6
Condit. Reinf. active responses0.30.30.8-0.5-0.5-0.4-0.6-0.9-0.5
Condit. Reinf. inactive responses0.00.10.10.30.20.30.1-0.10.3
Incentive salience index mean0.20.30.6-0.5-0.5-0.4-0.5-0.8-0.6
Condit. Reinf. lever presses0.00.00.1-0.1-0.1-0.1-0.1-0.3-0.1
Condit. Reinf. active minus inactive responses0.10.10.2-0.4-0.3-0.3-0.3-0.4-0.3
Condit. Reinf. active-inactive response ratio0.50.50.8-0.7-0.7-0.6-0.8-0.9-0.7
Condit. Reinf. active responses0.10.10.10.30.30.30.30.30.2
Condit. Reinf. inactive responses0.70.91.01.01.00.91.01.00.9
Condit. Reinf. lever presses0.20.20.3-0.5-0.4-0.4-0.5-0.5-0.4
Condit. Reinf. lever reinforcers received0.10.10.10.30.30.30.30.30.3
Conditioned reinforcement - actives1.32.22.5-1.6-1.5-1.4-1.5-1.6-1.4
Conditioned reinforcement - inactives0.40.60.6-0.8-0.8-0.8-0.7-0.7-0.8
Conditioned locomotion2.43.13.4-1.8-1.7-1.7-1.8-1.8-1.7
Patch foraging indifference point 0 sec0.40.80.9-1.0-0.9-0.9-0.9-0.8-0.9
Patch foraging indifference point AUC2.94.24.8-2.2-2.1-2.2-2.0-1.8-2.1
Delay disc. indifference point, 0s delay1.41.51.71.31.21.21.21.31.2
Delay disc. indifference point, 16s delay1.21.31.51.21.11.11.11.21.0
Delay disc. indifference point, 2s delay3.74.15.72.02.01.92.12.41.8
Delay disc. indifference point, 24s delay0.10.10.1-0.3-0.2-0.2-0.3-0.3-0.0
Delay disc. indifference point, 4s delay0.00.00.00.00.0-0.00.10.20.0
Delay disc. indifference point, 8s delay1.72.02.41.41.41.41.41.61.3
Indifference point function ln k0.81.41.61.31.21.21.10.91.2
Indifference point function log k0.81.41.61.31.21.21.10.91.2
Patch foraging total patch changes 0 sec0.61.21.3-1.1-1.1-1.1-1.1-1.1-1.0
Patch foraging total patch changes 12 sec1.41.82.0-1.4-1.3-1.4-1.3-1.2-1.3
Patch foraging total patch changes 18 sec1.93.03.2-1.8-1.7-1.7-1.7-1.7-1.6
Patch foraging total patch changes 24 sec0.30.50.5-0.7-0.7-0.7-0.7-0.7-0.6
Patch foraging total patch changes 6 sec2.43.74.2-2.0-1.9-2.0-1.9-1.8-1.9
Patch foraging time to switch 0 sec2.75.56.42.42.32.32.42.52.2
Patch foraging water rate 0 sec2.96.26.7-2.6-2.5-2.5-2.5-2.5-2.4
Patch foraging water rate 12 sec0.10.30.4-0.5-0.5-0.4-0.6-0.6-0.4
Patch foraging water rate 18 sec0.10.20.2-0.4-0.4-0.4-0.5-0.5-0.3
Patch foraging water rate 24 sec0.60.80.9-1.0-0.9-0.9-0.9-1.0-0.8
Patch foraging water rate 6 sec0.71.01.3-1.0-1.0-0.9-1.0-1.1-0.9
Seeking ratio, delayed vs. immediate footshock1.92.42.81.71.61.61.51.41.5
Distance traveled before self-admin0.10.10.2-0.4-0.3-0.3-0.3-0.3-0.3
Distance traveled after self-admin0.10.20.20.40.40.40.40.40.5
Extensor digitorum longus weight1.87.17.3-2.7-2.7-2.6-2.7-2.7-2.6
Bone: elastic displacement1.01.21.71.31.11.11.10.90.9
Bone: elastic work0.00.00.0-0.0-0.1-0.1-0.1-0.2-0.1
Bone: endosteal estimation0.00.10.10.30.20.30.20.00.3
Bone: endosteal perimeter0.00.00.00.00.00.00.0-0.10.0
Epididymis fat weight0.20.81.00.90.90.91.01.00.8
Delta time in closed arm before/after self-admin0.10.10.10.30.30.30.30.20.3
Delta time in open arm before/after self-admin0.00.00.00.10.20.20.20.20.2
Diff in mean of infusions in LGA sessions1.41.71.81.31.31.31.31.31.3
Delay discount exponential model param1.31.52.0-1.2-1.2-1.1-1.2-1.4-1.1
Extinction: sum of active levers before priming0.10.10.10.30.30.20.30.20.2
Active lever presses in extinction session 60.10.10.1-0.3-0.3-0.3-0.2-0.2-0.2
Bone: final force0.40.60.7-0.8-0.8-0.8-0.8-0.8-0.7
Bone: final moment0.50.91.0-1.0-0.9-0.9-0.9-0.9-0.8
Food consumed during 24 hour testing period5.17.17.82.82.72.72.62.42.7
Glucose0.30.40.70.60.60.50.70.90.5
Heart weight2.33.54.1-2.0-1.9-1.9-1.8-1.7-1.8
Delay discount hyperbolic model param1.21.31.9-1.1-1.1-1.1-1.2-1.4-1.0
Intermittent access intake day 1-15 change0.10.10.2-0.4-0.4-0.4-0.4-0.4-0.3
Intermittent access intake escalation0.10.20.3-0.5-0.5-0.5-0.5-0.5-0.4
Intermittent access intake escalation 20.00.00.0-0.1-0.1-0.1-0.1-0.1-0.0
Intermitt. access day 1 inactive lever presses0.00.00.0-0.1-0.1-0.1-0.1-0.0-0.0
Intermitt. access day 15 inactive lever presses0.00.00.0-0.0-0.0-0.0-0.0-0.0-0.0
Intermitt. access escalation Index0.20.30.40.60.50.60.50.50.5
Intermittent access day 1 total infusions1.42.32.5-1.6-1.5-1.5-1.5-1.5-1.5
Intermittent access day 15 total infusions0.71.11.2-1.1-1.0-1.1-1.0-1.0-1.0
Intermittent access terminal intake (last 3 days)1.11.51.7-1.3-1.2-1.2-1.2-1.2-1.1
Intermittent access total infusions2.52.93.3-1.8-1.7-1.7-1.7-1.7-1.7
Intermittent access day 1 locomotion0.30.40.4-0.6-0.6-0.6-0.6-0.6-0.6
Intermittent access day 15 total locomotion0.10.20.3-0.5-0.5-0.5-0.5-0.4-0.5
Intermittent access total locomotion1.62.02.2-1.5-1.4-1.4-1.4-1.4-1.4
Intermittent access standard deviation0.10.20.30.50.40.40.50.50.5
Left kidney weight5.726.328.9-5.4-5.0-4.9-5.2-5.3-4.9
Right kidney weight5.223.826.2-5.1-4.8-4.7-4.9-5.0-4.7
Cocaine induced anxiety0.20.30.40.60.50.50.60.60.4
Post-drug Anxiety0.00.00.10.30.20.20.20.30.1
Baseline Anxiety0.00.00.0-0.0-0.0-0.0-0.0-0.0-0.0
Tail length0.31.31.5-1.2-1.2-1.2-1.1-0.9-1.2
Length with tail0.31.41.6-1.3-1.2-1.2-1.2-1.1-1.1
Length without tail0.41.21.9-1.1-1.0-0.9-1.1-1.4-0.9
Times rat made contact with spout0.00.00.00.10.10.2-0.0-0.20.1
Lifetime Intake2.42.93.2-1.8-1.7-1.7-1.7-1.6-1.7
Liver weight, left2.13.53.8-2.0-1.9-1.9-1.8-1.7-2.0
Liver weight, right1.32.22.5-1.5-1.4-1.4-1.5-1.6-1.5
Locomotor activity2.23.54.2-2.1-1.9-2.0-1.8-1.5-1.9
Locomotor testing distance1.22.12.5-1.6-1.5-1.6-1.4-1.1-1.5
Locomotor testing rearing4.48.910.0-3.2-3.0-3.0-2.9-2.8-3.0
Locomotion in novel chamber0.10.20.30.30.40.40.40.40.6
Locomotion in novel chamber post-restriction0.81.41.81.31.21.11.21.21.0
Fecal boli incidents, locomotor time 10.00.00.1-0.3-0.2-0.2-0.2-0.1-0.3
Change in fecal boli incidents, locomotor task0.90.91.00.90.90.90.91.00.9
Time >=10cm from walls, locomotor time 10.00.00.10.00.10.1-0.0-0.30.1
Bouts of movement, locomotor time 12.42.73.11.71.71.71.61.41.8
Total resting periods, locomotor time 13.13.54.01.91.91.91.81.72.0
Rest time, locomotor task time 10.20.20.40.50.50.50.40.30.6
Distance moved, locomotor task time 10.30.50.7-0.7-0.7-0.8-0.7-0.5-0.8
Vertical activity count, locomotor time 10.00.00.10.00.10.00.10.30.0
Time >=10cm from walls, locomotor time 20.10.10.20.30.30.20.30.50.2
Bouts of movement, locomotor time 24.57.17.72.82.72.72.62.52.7
Total resting periods, locomotor time 23.66.36.82.62.52.62.42.32.6
Rest time, locomotor task time 20.00.00.10.20.20.30.1-0.20.3
Distance moved, locomotor task time 20.80.91.2-1.0-1.0-1.0-0.9-0.6-1.1
Vertical activity count, locomotor time 20.10.10.40.30.30.20.40.70.2
Light reinforcement 10.00.10.2-0.3-0.3-0.3-0.4-0.4-0.3
Light reinforcement 20.00.10.1-0.3-0.3-0.3-0.3-0.2-0.2
Bone: marrow area0.00.00.10.30.20.20.1-0.00.2
Bone: maximum diameter2.34.34.6-2.1-2.1-2.1-2.1-2.1-2.0
Bone: maximum force0.10.30.3-0.6-0.5-0.5-0.5-0.5-0.4
Bone: maximum moment0.20.40.5-0.7-0.6-0.6-0.6-0.6-0.5
Mean time between licks in bursts0.00.10.10.30.30.30.30.40.3
Mean num. licks in bursts2.53.94.92.22.12.21.81.32.2
Cd content in liver0.10.10.10.20.20.30.1-0.20.3
Co content in liver1.31.51.61.21.21.21.21.21.2
Cu content in liver0.30.40.4-0.7-0.6-0.7-0.6-0.5-0.6
Fe content in liver5.06.07.2-2.7-2.5-2.6-2.4-1.9-2.6
K content in liver0.10.10.2-0.4-0.4-0.5-0.3-0.2-0.4
Mg content in liver0.50.50.7-0.8-0.7-0.8-0.7-0.5-0.8
Mn content in liver1.01.11.2-1.1-1.0-1.0-1.0-1.1-1.0
Na content in liver0.20.20.3-0.5-0.5-0.6-0.4-0.2-0.4
Rb content in liver0.10.20.5-0.3-0.3-0.2-0.4-0.7-0.2
Se content in liver3.74.35.2-2.3-2.1-2.2-2.0-1.5-2.2
Sr content in liver0.00.00.1-0.2-0.2-0.2-0.10.2-0.2
Zn content in liver0.80.90.9-0.9-0.9-0.9-0.9-1.0-0.9
Bone: minimum diameter0.20.30.3-0.5-0.6-0.6-0.6-0.5-0.5
Time in familiar zone, hab. session 10.20.20.2-0.5-0.4-0.5-0.4-0.4-0.5
Time in novel zone, hab. session 10.60.60.6-0.8-0.8-0.8-0.7-0.7-0.7
Total zone transitions, hab. session 10.20.20.4-0.5-0.5-0.4-0.5-0.6-0.4
Total locomotion distance, hab. session 10.40.60.70.80.70.70.70.80.7
Locomotion velocity, hab. session 11.21.81.91.41.31.31.31.41.3
Time in familiar zone, hab. session 20.20.30.4-0.6-0.5-0.6-0.4-0.2-0.7
Time in novel zone, hab. session 20.00.00.10.20.20.20.1-0.10.3
Total zone transitions, hab. session 20.50.60.8-0.9-0.8-0.9-0.8-0.6-0.8
Total locomotion distance, hab. session 20.50.70.90.90.80.80.91.00.7
Locomotion velocity, hab. session 20.30.50.60.70.70.60.70.80.6
Novel to familiar place preference ratio0.70.81.9-0.8-0.8-0.7-1.0-1.4-0.6
Novelty place preference0.70.71.7-0.7-0.8-0.6-0.9-1.3-0.6
Time in novel zone, NPP test0.80.91.9-0.8-0.9-0.8-1.0-1.4-0.7
Total zone transitions, NPP test0.10.20.2-0.4-0.4-0.4-0.4-0.3-0.3
Total locomotion distance, NPP test0.10.10.2-0.4-0.4-0.4-0.4-0.3-0.3
Locomotion velocity, NPP test0.10.10.1-0.3-0.3-0.3-0.3-0.3-0.3
Intraocular pressure0.00.00.00.00.00.10.0-0.10.0
Delta distance traveled before/after self-admin2.02.12.41.51.41.41.41.41.4
Delta ambulatory time before/after self-admin0.40.50.60.80.70.70.70.70.7
Parametrial fat weight0.10.10.1-0.4-0.4-0.4-0.4-0.4-0.4
Pavlov. Cond. lever latency0.50.71.00.70.80.70.81.00.8
Pavlov. Cond. magazine entry latency0.10.10.2-0.2-0.2-0.2-0.3-0.5-0.4
Pavlov. Cond. change in total contacts0.60.60.80.90.80.90.70.50.8
Pavlov. Cond. index score0.30.30.5-0.5-0.5-0.5-0.5-0.7-0.6
Pavlov. Cond. latency score0.10.10.1-0.2-0.2-0.2-0.2-0.4-0.3
Pavlov. Cond. lever contacts0.30.40.6-0.5-0.6-0.5-0.6-0.8-0.7
Pavlov. Cond. magazine entry number0.00.00.10.10.10.00.10.20.2
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.3-0.3-0.3-0.3-0.4-0.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.5-0.6-0.6-0.5-0.6-0.7-0.6
Pavlov. Cond. response bias0.91.11.6-1.0-1.0-0.9-1.0-1.3-1.1
Pavlov. Cond. lever latency0.00.00.00.20.10.20.10.20.1
Pavlov. Cond. magazine entry latency0.10.10.5-0.1-0.10.0-0.3-0.7-0.0
Pavlov. Cond. change in total contacts0.10.20.30.50.50.50.40.20.6
Pavlov. Cond. index score0.00.00.10.10.10.20.0-0.20.2
Pavlov. Cond. latency score0.00.10.10.20.30.30.2-0.10.3
Pavlov. Cond. lever contacts0.10.10.2-0.4-0.3-0.3-0.3-0.4-0.3
Pavlov. Cond. magazine entry number0.30.30.5-0.6-0.6-0.7-0.5-0.1-0.7
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.0-0.1-0.1-0.00.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.2-0.1-0.00.0-0.1-0.40.0
Pavlov. Cond. response bias0.00.00.1-0.00.00.1-0.0-0.30.1
Time in closed arm before self-admin0.81.11.3-1.1-1.0-1.0-1.1-1.1-0.9
Time in closed arm after self-admin0.80.80.90.90.90.90.90.90.9
Time in open arm before self-admin0.90.91.21.11.00.91.01.00.8
Time in open arm after self-admin0.10.10.20.40.40.30.40.40.3
Bone: periosteal estimation0.20.50.7-0.7-0.7-0.7-0.7-0.8-0.6
Bone: periosteal perimeter0.30.40.5-0.7-0.7-0.7-0.7-0.7-0.6
Bone: post-yield work0.81.11.31.11.11.11.01.01.1
Progressive ratio test 1 active lever presses2.63.23.5-1.9-1.8-1.8-1.8-1.7-1.8
Progressive ratio test 1 breakpoint2.32.83.1-1.8-1.7-1.7-1.7-1.6-1.6
Progressive ratio test 1 inactive lever presses1.31.82.0-1.4-1.4-1.4-1.3-1.3-1.3
Progressive ratio test 2 active lever presses2.22.62.8-1.7-1.6-1.6-1.6-1.5-1.7
Progressive ratio test 2 breakpoint2.52.93.1-1.8-1.7-1.7-1.7-1.6-1.8
Progressive ratio test 2 inactive lever presses0.10.20.2-0.4-0.4-0.5-0.4-0.3-0.5
Incentive Sensitization - Responses1.11.61.7-1.3-1.3-1.3-1.2-1.2-1.3
Incentive Sensitization - Breakpoint1.11.41.5-1.2-1.2-1.2-1.1-1.1-1.2
Sum of active levers in priming session hrs 5-60.30.30.30.50.50.50.50.50.5
Progressive ratio1.11.72.11.51.31.31.31.41.1
Food seeking constrained by brief footshock5.46.67.02.62.62.62.52.42.6
Seeking ratio, punishment vs. effort0.60.81.30.90.90.90.80.71.1
Retroperitoneal fat weight0.00.10.1-0.4-0.3-0.3-0.3-0.3-0.3
Reaction time number correct4.07.68.4-2.9-2.8-2.8-2.8-2.7-2.7
Reaction time mean minus median0.00.10.20.30.30.40.3-0.00.5
Reaction time mean minus median AUC0.10.20.7-0.5-0.4-0.3-0.5-0.8-0.2
Reaction time num false alarms4.36.06.5-2.6-2.4-2.4-2.5-2.5-2.4
Reaction time num false alarms AUC3.35.15.6-2.4-2.3-2.2-2.3-2.2-2.3
Reaction time trials correct on left4.07.68.4-2.9-2.8-2.8-2.8-2.7-2.7
Reaction time trials on left4.07.68.4-2.9-2.8-2.8-2.8-2.7-2.7
Reaction time mean1.11.82.21.41.41.51.30.91.5
Reaction time mean AUC0.81.31.71.21.21.31.10.81.3
Median of all reaction times1.62.22.61.61.51.61.41.21.6
Reaction time omissions0.00.00.2-0.0-0.00.1-0.1-0.40.1
Reaction time false alarm rate0.10.10.2-0.4-0.4-0.4-0.4-0.4-0.4
Reaction time premature initiation rate0.40.60.80.90.80.80.70.50.8
Reaction time premature initiations0.30.50.8-0.6-0.6-0.6-0.7-0.9-0.6
Std. dev. reaction times0.10.30.40.50.50.60.50.30.7
Reaction time trials completed4.07.68.4-2.9-2.8-2.8-2.8-2.7-2.7
Reaction time trials AUC4.89.210.1-3.2-3.0-3.0-3.0-3.0-3.0
Run reversals in cocaine runway, females0.30.30.40.50.50.50.50.60.6
Run reversals in cocaine runway, males0.50.50.5-0.7-0.7-0.7-0.7-0.7-0.7
Latency to leave start box in cocaine runway0.10.10.2-0.3-0.3-0.2-0.4-0.5-0.1
Latency to leave start box in cocaine runway, F0.80.90.9-1.0-0.9-0.9-1.0-1.0-0.8
Latency to leave start box in cocaine runway, M0.10.10.20.40.40.40.30.10.4
Std. dev. time between licks in bursts0.00.00.1-0.0-0.10.0-0.2-0.3-0.1
Total sessions with >9 infusions3.84.65.2-2.3-2.2-2.2-2.1-2.0-2.1
Short access day 1 total inactive lever presses0.40.60.6-0.8-0.8-0.8-0.8-0.7-0.8
Short access day 10 total inactive lever presses0.61.41.61.31.21.21.21.21.2
Short access day 1 total infusions1.92.62.8-1.7-1.6-1.6-1.6-1.5-1.6
Short access day 10 total infusions3.64.65.1-2.3-2.1-2.1-2.1-2.1-2.1
Short access total infusions2.22.83.0-1.7-1.7-1.7-1.6-1.6-1.7
Short access day 1 locomotion3.24.04.4-2.1-2.0-2.0-2.0-1.9-2.0
Short access day 10 total locomotion0.00.00.0-0.1-0.1-0.1-0.1-0.20.0
Short access total locomotion0.80.91.1-1.0-1.0-0.9-1.0-1.0-0.9
One hour access (0.3 mA shock)0.00.00.0-0.2-0.2-0.2-0.2-0.2-0.1
Compulsive drug intake0.30.30.5-0.6-0.5-0.5-0.6-0.7-0.4
One hour access (shock baseline)0.81.31.4-1.2-1.1-1.1-1.1-1.0-1.1
Social response proportion1.11.32.1-1.1-1.1-1.0-1.2-1.4-0.9
Social responses0.91.11.4-1.1-1.0-1.0-1.1-1.2-1.0
Social time3.34.44.82.22.12.12.12.02.2
Soleus weight0.10.40.6-0.6-0.6-0.6-0.6-0.8-0.5
Bone: stiffness0.81.21.6-1.3-1.1-1.2-1.1-1.0-1.0
Tibialis anterior weight3.311.312.3-3.4-3.3-3.3-3.4-3.5-3.2
Time to tail flick, vehicle, before self-admin3.03.13.3-1.8-1.8-1.8-1.7-1.7-1.8
Time to tail flick, vehicle, after self-admin0.00.00.0-0.2-0.1-0.1-0.1-0.1-0.2
Time to tail flick, test, before self-admin0.40.50.50.70.70.70.70.70.6
Time to tail flick, test, after self-admin0.20.20.30.50.40.40.50.50.3
Delta time to tail flick, vehicle, before/after SA0.10.10.10.30.30.30.30.30.3
Delta time to tail flick, test, before/after SA0.80.80.9-1.0-0.9-0.9-0.9-0.9-0.9
Tibia length0.20.60.8-0.9-0.7-0.7-0.8-0.9-0.8
Ambulatory time before self-admin0.00.00.0-0.00.00.00.00.00.1
Ambulatory time after self-admin0.40.50.50.70.70.70.70.70.7
Bone: tissue strength0.80.81.01.00.90.90.90.81.0
Total heroin consumption0.00.00.00.10.10.10.10.10.1
Bone: trabecular number0.00.10.20.30.30.40.2-0.00.3
Bone: trabecular spacing0.00.10.1-0.2-0.3-0.3-0.2-0.2-0.3
Bone: trabecular thickness1.41.72.0-1.4-1.3-1.2-1.4-1.4-1.2
Bone: trabecular tissue density0.30.50.6-0.8-0.7-0.7-0.7-0.6-0.8
Water consumed over 24 hours0.10.20.30.50.40.50.30.10.5
Number of responses in last shaping day3.13.43.8-1.9-1.8-1.8-1.8-1.8-1.8