Polg2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Polg2	0.07	0.05	2.2e-03	0.03	0.03	0.04	0.04	3.8e-03	1.6e-03	3.3e-04	3.1e-04
2	PL	gene expression	Polg2	0.04	0.02	6.4e-05	0.04	0.04	0.04	0.03	7.9e-05	4.7e-05	2.8e-05	3.1e-04
3	NAcc	gene expression	Polg2	0.02	0.01	7.2e-04	0.03	0.02	0.02	0.02	4.4e-05	9.1e-04	1.4e-04	3.4e-04
4	Liver	alternative TSS	NM_001107060.1	0.04	0.02	1.9e-05	0.02	0.04	0.01	0.02	1.8e-03	7.2e-05	1.1e-02	1.7e-03
5	Adipose	alternative TSS	XM_063269211.1	0.03	0.02	2.2e-03	0.03	0.01	0	0.01	5.7e-04	1.1e-02	2.0e-01	1.2e-02
6	Adipose	alternative TSS	NM_001107060.1	0.03	0.02	5.5e-04	0.03	0.02	0.01	0.02	9.2e-05	1.8e-03	1.1e-02	1.1e-03
7	Adipose	alternative TSS	NM_001107060.1	0.03	0.02	2.5e-03	0.03	0.02	0	0.01	7.5e-04	5.5e-03	1.8e-01	8.2e-03
8	Adipose	alternative TSS	XM_063269212.1	0.03	0.02	5.4e-03	0.02	0.01	0	0.01	1.2e-03	2.0e-02	3.2e-01	2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.3	0.6	1.6	-0.9	-0.8	-1.0	1.3	0.3	-0.2	-0.3	0.3
Area under the delay curve	0.1	0.1	0.4	-0.5	-0.2	0.1	0.6	0.2	-0.1	-0.3	0.3
BMI with tail	0.9	3.1	11.5	-3.4	-1.9	-2.4	2.0	-0.0	0.2	0.4	-0.4
BMI without tail	2.2	6.6	20.7	-4.5	-3.2	-3.3	3.2	0.4	-0.4	-0.3	0.3
Body weight	2.8	12.0	24.9	-5.0	-4.3	-4.4	4.4	2.0	-1.9	-1.7	1.7
Weight adjusted by age	0.3	0.4	1.0	0.7	0.8	1.0	-0.7	-0.4	0.5	0.5	-0.5
Bone surface	3.2	5.8	10.3	-2.8	-3.0	-3.1	3.2	1.6	-1.6	-1.5	1.5
Bone volume	2.5	4.5	8.5	-2.5	-2.6	-2.7	2.9	1.4	-1.4	-1.4	1.4
Breakpoint value in progressive ratio session	0.2	0.3	0.6	0.8	0.2	0.4	-0.6	-0.6	0.5	0.5	-0.5
Number of licking bursts	0.0	0.0	0.1	0.3	0.1	0.2	-0.2	-0.1	0.0	0.0	-0.0
Context. condit. distance diff. score	0.1	0.1	0.3	-0.2	0.2	0.2	-0.2	-0.5	0.5	0.3	-0.3
Locomotion velocity, session 1	0.5	0.6	1.4	-1.0	-0.9	-1.1	1.2	0.2	-0.2	-0.3	0.3
Locomotion distance, session 1	0.4	0.6	2.0	-1.4	-0.5	-0.9	0.8	-0.5	0.5	0.4	-0.4
Locomotion velocity, session 2	0.1	0.2	0.6	-0.5	-0.6	-0.8	0.2	-0.0	-0.0	-0.1	0.1
Locomotion distance, session 2	0.5	0.6	1.5	-0.5	-0.0	-0.2	0.0	-0.9	0.9	1.2	-1.2
Locomotion velocity, session 3	1.2	1.4	2.4	0.0	0.9	0.8	-0.7	-1.5	1.6	1.5	-1.5
Locomotion distance, session 3	0.2	0.2	0.3	-0.3	0.0	-0.1	-0.0	-0.6	0.6	0.6	-0.6
Stereotopy head waving bouts, day 3	0.5	0.6	1.0	1.0	1.0	1.0	-0.6	-0.6	0.6	0.5	-0.5
Stereotopy head waving duration, day 3	0.5	0.6	1.2	0.9	0.9	1.1	-0.6	-0.7	0.7	0.5	-0.5
Locomotion velocity, session 7	0.4	0.4	0.6	0.3	0.7	0.3	-0.7	-0.7	0.8	0.8	-0.8
Locomotion distance, session 7	0.0	0.0	0.1	-0.4	-0.1	-0.2	-0.1	-0.0	0.1	-0.1	0.1
Stereotopy head waving bouts, day 7	1.5	1.7	2.4	1.5	1.4	1.5	-1.2	-1.1	1.1	1.3	-1.3
Stereotopy head waving duration, day 7	2.9	3.5	5.8	2.4	2.1	2.3	-1.9	-1.4	1.3	1.6	-1.6
Locomotion velocity, session 8	0.3	0.4	0.9	-0.6	-0.9	-1.0	0.7	0.4	-0.5	-0.3	0.3
Locomotion distance, session 8	0.2	0.2	0.5	-0.7	-0.3	-0.3	0.2	-0.5	0.5	0.6	-0.6
Degree of sensitization distance	0.7	0.7	1.1	-0.5	-0.7	-0.7	0.7	0.9	-0.9	-1.0	1.0
Degree of sensitization stereotypy	2.3	2.4	3.0	1.3	1.5	1.5	-1.6	-1.6	1.5	1.7	-1.7
Conditioned locomotion	0.4	0.5	0.9	-0.5	-0.7	-0.5	0.6	1.0	-0.9	-0.6	0.6
Cocaine response after cond. corrected	0.3	0.4	1.3	1.1	0.8	0.8	-0.5	-0.3	0.3	0.5	-0.5
Cocaine response after cond. not corrected	1.0	1.1	2.9	1.7	1.2	1.2	-1.0	-0.7	0.8	0.8	-0.8
Cocaine response before conditioning	0.4	0.5	0.8	0.3	0.6	0.6	-0.7	-0.9	0.9	0.7	-0.7
Saline control response	0.7	1.0	1.4	-0.9	-1.1	-0.7	0.7	1.1	-1.2	-1.0	1.0
Bone: connectivity density	0.9	1.4	3.0	-1.4	-1.5	-1.6	1.7	0.6	-0.6	-0.7	0.7
Bone: cortical apparent density	3.1	4.3	5.9	0.8	2.3	1.9	-1.8	-2.4	2.4	2.2	-2.2
Bone: cortical area	1.4	2.2	8.3	-2.9	-1.1	-1.5	1.4	-0.9	0.9	1.1	-1.1
Bone: cortical porosity	1.2	1.3	2.7	-0.8	-1.7	-1.4	1.3	1.0	-1.0	-0.7	0.7
Bone: cortical porosity	1.0	1.1	2.4	-1.3	-1.5	-1.3	1.5	0.5	-0.5	-0.3	0.3
Bone: cortical thickness	8.5	14.1	22.9	-0.1	3.3	2.5	-2.6	-4.6	4.7	4.8	-4.8
Bone: cortical thickness	5.7	6.7	11.0	-0.3	2.2	1.7	-2.1	-3.1	3.1	3.3	-3.3
Bone: cortical tissue density	3.0	4.1	5.4	0.9	2.3	1.9	-1.9	-2.3	2.3	2.1	-2.1
Condit. Reinf. active minus inactive responses	1.0	1.1	1.9	-1.4	-1.2	-0.9	1.2	1.0	-1.0	-0.8	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.3	-0.5	-0.2	0.5	0.6	-0.6	-0.6	0.6
Condit. Reinf. active responses	1.9	2.3	3.8	-2.0	-1.7	-1.4	1.7	1.4	-1.5	-1.1	1.1
Condit. Reinf. inactive responses	1.3	1.6	3.4	-1.9	-1.5	-1.4	1.5	0.9	-1.0	-0.7	0.7
Incentive salience index mean	0.7	0.9	1.4	-1.2	-1.1	-0.8	1.1	0.9	-0.9	-0.6	0.6
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.1	-0.2	0.2	0.1	0.3	-0.3	-0.1	0.1
Condit. Reinf. active minus inactive responses	2.4	3.1	6.8	-2.6	-2.5	-2.0	2.4	0.8	-0.8	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.8	1.0	2.0	-0.7	-1.4	-0.8	1.4	1.0	-1.0	-0.6	0.6
Condit. Reinf. active responses	4.0	5.6	11.7	-3.4	-3.3	-2.7	2.9	1.4	-1.4	-1.2	1.2
Condit. Reinf. inactive responses	2.6	3.4	11.1	-3.3	-2.3	-2.3	1.9	0.7	-0.7	-0.7	0.7
Condit. Reinf. lever presses	1.0	1.4	5.0	-2.2	-1.7	-1.4	1.3	0.3	-0.3	-0.2	0.2
Condit. Reinf. lever reinforcers received	3.5	4.9	10.0	-3.2	-3.0	-2.5	2.7	1.3	-1.3	-1.1	1.1
Conditioned reinforcement - actives	0.2	0.3	0.7	-0.6	-0.9	-0.5	0.9	0.2	-0.4	-0.4	0.4
Conditioned reinforcement - inactives	1.0	1.4	4.1	-1.6	-1.4	-2.0	1.4	0.4	-0.5	-0.5	0.5
Conditioned locomotion	2.4	3.1	4.3	-2.0	-2.0	-1.9	2.1	1.5	-1.5	-1.5	1.5
Patch foraging indifference point 0 sec	3.4	6.2	16.2	-4.0	-3.0	-3.0	3.0	1.5	-1.4	-1.3	1.3
Patch foraging indifference point AUC	1.1	1.5	2.8	-1.7	-1.6	-1.5	1.5	0.7	-0.8	-0.9	0.9
Delay disc. indifference point, 0s delay	0.3	0.3	0.9	1.0	0.7	0.9	-0.4	0.1	-0.2	-0.2	0.2
Delay disc. indifference point, 16s delay	0.2	0.2	0.8	-0.7	-0.5	-0.1	0.9	0.1	-0.1	-0.2	0.2
Delay disc. indifference point, 2s delay	0.8	0.9	2.1	-0.8	-0.9	-0.7	1.4	0.9	-0.8	-0.9	0.9
Delay disc. indifference point, 24s delay	1.7	1.9	5.9	-2.4	-1.6	-1.3	1.9	0.5	-0.3	-0.6	0.6
Delay disc. indifference point, 4s delay	0.6	0.6	1.3	0.9	1.1	1.1	-0.8	-0.6	0.7	0.5	-0.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.2	-0.0	0.3	0.4	0.2	-0.1	0.0	-0.0	0.0
Indifference point function ln k	0.8	1.5	2.4	0.1	1.1	1.1	-0.9	-1.4	1.4	1.5	-1.5
Indifference point function log k	0.8	1.5	2.4	0.1	1.1	1.1	-0.9	-1.4	1.4	1.5	-1.5
Patch foraging total patch changes 0 sec	3.4	6.5	15.8	-4.0	-3.0	-3.0	3.1	1.6	-1.5	-1.3	1.3
Patch foraging total patch changes 12 sec	6.9	9.0	11.6	-3.2	-3.4	-3.3	3.2	2.8	-2.6	-2.7	2.7
Patch foraging total patch changes 18 sec	2.4	3.6	6.7	-2.6	-2.5	-2.4	2.0	1.3	-1.3	-1.3	1.3
Patch foraging total patch changes 24 sec	2.9	5.0	13.0	-3.6	-2.8	-2.7	2.8	1.1	-1.1	-1.1	1.1
Patch foraging total patch changes 6 sec	2.8	4.2	10.5	-3.2	-2.4	-2.8	2.4	1.0	-1.0	-1.0	1.0
Patch foraging time to switch 0 sec	0.4	0.8	3.0	1.7	1.1	0.9	-1.1	0.3	-0.2	-0.2	0.2
Patch foraging water rate 0 sec	1.6	3.3	9.2	-3.0	-2.3	-2.4	2.2	0.7	-0.6	-0.6	0.6
Patch foraging water rate 12 sec	1.1	2.3	4.8	-0.3	0.9	0.5	-0.8	-2.2	2.0	2.0	-2.0
Patch foraging water rate 18 sec	0.9	1.4	2.7	-0.7	0.2	-0.0	0.0	-1.6	1.6	1.6	-1.6
Patch foraging water rate 24 sec	0.2	0.2	0.5	0.2	0.1	0.1	-0.0	-0.6	0.6	0.7	-0.7
Patch foraging water rate 6 sec	0.3	0.5	1.0	-0.5	0.0	0.1	0.2	-1.0	1.0	0.9	-0.9
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.3	-0.5	-0.2	0.0	0.0	-0.1	0.2	0.1	-0.1
Distance traveled before self-admin	0.9	1.2	1.8	1.2	1.2	1.3	-1.1	-0.9	1.0	1.1	-1.1
Distance traveled after self-admin	0.2	0.3	0.6	0.2	0.4	0.4	-0.5	-0.8	0.6	0.6	-0.6
Extensor digitorum longus weight	0.4	1.6	2.9	1.7	1.7	1.7	-1.7	0.9	-0.7	-0.5	0.5
Bone: elastic displacement	3.4	3.9	5.5	0.9	1.9	1.7	-1.6	-2.4	2.2	2.3	-2.3
Bone: elastic work	0.7	0.9	1.7	-1.1	0.2	-0.2	0.0	-1.3	1.1	1.3	-1.3
Bone: endosteal estimation	12.6	27.7	39.1	-4.3	-6.3	-6.0	5.6	4.9	-5.0	-4.9	4.9
Bone: endosteal perimeter	13.7	29.2	42.0	-4.8	-6.5	-6.1	6.2	4.9	-4.9	-4.8	4.8
Epididymis fat weight	0.4	1.4	1.9	-1.2	-1.3	-1.3	1.4	1.0	-1.1	-1.1	1.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.4	0.3	0.0	-0.2	0.5	-0.6	-0.4	0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.3	0.0	0.5	-0.1	0.2	-0.3	-0.5	0.5
Diff in mean of infusions in LGA sessions	1.9	2.3	3.3	1.2	1.8	1.5	-1.8	-1.4	1.4	1.5	-1.5
Delay discount exponential model param	0.2	0.2	0.7	0.7	0.3	0.1	-0.8	-0.3	0.3	0.4	-0.4
Extinction: sum of active levers before priming	0.0	0.0	0.3	-0.5	-0.0	0.2	-0.1	0.0	-0.1	-0.0	0.0
Active lever presses in extinction session 6	0.9	0.9	2.0	-1.4	-1.0	-0.9	0.9	0.6	-0.7	-0.9	0.9
Bone: final force	0.9	1.5	3.8	-2.0	-0.9	-1.4	1.1	-1.0	1.0	1.0	-1.0
Bone: final moment	1.0	1.5	3.7	-1.9	-0.8	-1.3	1.1	-1.0	1.1	1.1	-1.1
Food consumed during 24 hour testing period	2.2	3.0	4.5	-1.8	-2.1	-2.1	2.1	1.4	-1.5	-1.4	1.4
Glucose	1.1	1.8	2.3	1.3	1.3	1.5	-1.5	-1.2	1.2	1.3	-1.3
Heart weight	0.4	0.7	1.3	0.0	0.6	0.8	-0.1	-0.9	1.0	1.1	-1.1
Delay discount hyperbolic model param	0.2	0.3	0.7	0.6	0.4	0.1	-0.8	-0.5	0.4	0.5	-0.5
Intermittent access intake day 1-15 change	0.1	0.3	0.5	0.5	-0.0	0.1	-0.3	0.7	-0.7	-0.7	0.7
Intermittent access intake escalation	0.2	0.5	0.9	-0.1	-0.4	-0.3	0.2	0.9	-0.9	-0.9	0.9
Intermittent access intake escalation 2	1.1	1.2	2.3	-0.1	-0.7	-0.6	0.4	1.5	-1.5	-1.5	1.5
Intermitt. access day 1 inactive lever presses	0.6	2.3	3.7	-1.7	-1.9	-1.8	1.6	1.3	-1.1	-1.1	1.1
Intermitt. access day 15 inactive lever presses	0.7	1.4	2.1	-1.1	-1.1	-1.5	1.0	1.3	-1.1	-1.1	1.1
Intermitt. access escalation Index	2.7	3.8	5.5	2.1	2.4	2.2	-2.0	-1.6	1.7	1.7	-1.7
Intermittent access day 1 total infusions	0.6	1.0	2.8	-1.7	-1.1	-1.3	1.2	-0.5	0.5	0.5	-0.5
Intermittent access day 15 total infusions	0.9	1.3	2.3	-1.4	-1.5	-1.3	1.5	0.7	-0.7	-0.7	0.7
Intermittent access terminal intake (last 3 days)	2.5	3.3	4.9	-1.9	-2.2	-2.2	2.2	1.4	-1.4	-1.4	1.4
Intermittent access total infusions	2.2	2.7	5.9	-2.4	-2.1	-2.2	2.2	0.6	-0.6	-0.6	0.6
Intermittent access day 1 locomotion	2.1	2.7	7.9	-2.8	-2.0	-2.2	2.1	0.3	-0.2	-0.2	0.2
Intermittent access day 15 total locomotion	3.0	5.4	10.2	-3.2	-3.0	-2.8	2.8	1.3	-1.4	-1.4	1.4
Intermittent access total locomotion	6.1	7.3	18.6	-4.3	-3.4	-3.5	3.3	1.1	-1.1	-1.1	1.1
Intermittent access standard deviation	0.5	1.1	1.8	-1.3	-1.3	-1.3	1.0	0.9	-0.8	-0.8	0.8
Left kidney weight	0.6	2.6	5.6	-0.9	0.2	-0.0	-0.1	-2.4	2.2	2.2	-2.2
Right kidney weight	0.5	2.1	4.3	-0.7	-0.0	0.0	0.4	-2.1	2.0	1.9	-1.9
Cocaine induced anxiety	1.1	1.6	2.5	0.4	1.0	0.9	-0.9	-1.6	1.6	1.6	-1.6
Post-drug Anxiety	1.2	1.3	2.0	0.4	1.0	0.9	-0.8	-1.4	1.4	1.4	-1.4
Baseline Anxiety	0.0	0.0	0.1	0.3	0.2	0.2	-0.1	0.2	-0.2	-0.2	0.2
Tail length	2.1	8.2	13.7	-3.4	-3.7	-3.4	3.5	2.0	-2.0	-2.1	2.1
Length with tail	2.2	9.6	14.0	-2.8	-3.7	-3.3	3.7	2.7	-2.7	-2.8	2.8
Length without tail	0.6	2.0	3.2	-0.5	-1.2	-1.1	1.3	1.8	-1.8	-1.6	1.6
Times rat made contact with spout	0.5	0.6	1.1	-0.4	-1.0	-1.0	0.9	0.6	-0.7	-0.6	0.6
Lifetime Intake	2.4	2.9	7.3	-2.7	-2.3	-2.3	2.2	0.4	-0.4	-0.4	0.4
Liver weight, left	2.1	3.5	7.0	-2.1	-2.7	-2.3	2.5	1.2	-1.1	-1.1	1.1
Liver weight, right	1.6	2.8	6.1	-0.1	0.9	0.5	-0.7	-2.5	2.4	2.1	-2.1
Locomotor activity	1.1	1.8	3.6	-1.9	-0.8	-0.8	0.5	-1.4	1.5	1.5	-1.5
Locomotor testing distance	0.7	1.3	3.4	-1.8	-1.0	-0.7	0.5	-1.0	1.1	1.2	-1.2
Locomotor testing rearing	0.1	0.3	0.9	-0.9	-0.9	-0.8	0.1	-0.1	0.2	0.0	-0.0
Locomotion in novel chamber	0.1	0.2	0.4	0.6	0.4	0.1	-0.1	-0.4	0.5	0.3	-0.3
Locomotion in novel chamber post-restriction	1.6	2.7	3.8	-1.3	-1.7	-1.8	2.0	1.5	-1.5	-1.6	1.6
Fecal boli incidents, locomotor time 1	0.3	0.4	0.6	0.8	0.2	0.4	-0.1	0.8	-0.8	-0.8	0.8
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	-0.6	-0.3	-0.4	0.4	0.5	-0.4	-0.4	0.4
Time >=10cm from walls, locomotor time 1	2.3	2.5	3.3	1.6	1.3	1.2	-1.7	-1.6	1.8	1.6	-1.6
Bouts of movement, locomotor time 1	0.1	0.1	0.4	0.3	0.6	0.3	-0.5	-0.2	0.2	0.2	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.3	0.4	0.5	0.2	-0.4	-0.0	-0.0	-0.0	0.0
Rest time, locomotor task time 1	0.4	0.5	1.3	1.1	0.4	0.4	-0.3	0.7	-0.9	-0.7	0.7
Distance moved, locomotor task time 1	0.3	0.4	0.9	-1.0	-0.8	-0.9	0.9	0.1	-0.1	-0.0	0.0
Vertical activity count, locomotor time 1	0.1	0.2	0.6	-0.8	-0.6	-0.6	0.6	-0.1	0.2	0.2	-0.2
Time >=10cm from walls, locomotor time 2	0.3	0.5	1.6	1.3	0.6	0.4	-0.9	-0.5	0.7	0.5	-0.5
Bouts of movement, locomotor time 2	0.1	0.1	0.4	0.2	0.5	0.5	-0.6	-0.1	0.3	0.2	-0.2
Total resting periods, locomotor time 2	0.2	0.3	0.8	0.5	0.8	0.8	-0.9	-0.3	0.4	0.4	-0.4
Rest time, locomotor task time 2	2.4	3.1	8.0	2.8	2.2	2.3	-2.0	-0.7	0.6	0.8	-0.8
Distance moved, locomotor task time 2	0.2	0.3	1.1	-0.6	-0.7	-1.1	0.5	0.2	-0.1	-0.2	0.2
Vertical activity count, locomotor time 2	1.0	1.4	2.8	-1.6	-1.6	-1.7	1.2	0.7	-0.6	-0.8	0.8
Light reinforcement 1	0.2	0.4	2.4	-1.5	-0.3	-0.1	0.6	-0.3	0.4	0.3	-0.3
Light reinforcement 2	0.3	0.4	1.4	-1.2	-0.7	-0.4	0.9	0.2	-0.2	-0.2	0.2
Bone: marrow area	12.2	26.5	37.6	-4.2	-6.1	-5.8	5.5	4.8	-4.9	-4.8	4.8
Bone: maximum diameter	3.3	6.2	11.6	-3.4	-3.1	-3.1	3.2	1.6	-1.5	-1.4	1.4
Bone: maximum force	1.6	2.8	9.9	-3.1	-1.8	-2.2	2.1	-0.4	0.4	0.4	-0.4
Bone: maximum moment	1.6	2.7	9.5	-3.1	-1.7	-2.2	2.0	-0.4	0.4	0.5	-0.5
Mean time between licks in bursts	0.2	0.4	0.8	-0.4	-0.7	-0.7	0.9	0.6	-0.6	-0.6	0.6
Mean num. licks in bursts	0.2	0.4	0.6	-0.6	-0.7	-0.7	0.8	0.5	-0.6	-0.4	0.4
Cd content in liver	2.0	2.3	7.6	2.8	2.0	1.8	-1.8	-0.0	-0.1	-0.4	0.4
Co content in liver	0.9	1.1	2.4	1.6	1.3	1.3	-1.2	-0.7	0.6	0.4	-0.4
Cu content in liver	0.5	0.6	1.3	0.0	-0.6	-0.4	0.4	1.2	-1.1	-1.0	1.0
Fe content in liver	0.1	0.1	0.2	-0.3	-0.1	-0.1	-0.3	-0.3	0.5	0.4	-0.4
K content in liver	0.2	0.2	0.5	-0.5	-0.7	-0.5	0.7	0.2	-0.3	-0.2	0.2
Mg content in liver	0.2	0.2	0.7	0.8	0.5	0.6	-0.5	-0.0	0.0	-0.2	0.2
Mn content in liver	0.6	0.7	1.4	-0.3	0.2	0.0	-0.1	-1.2	1.2	1.1	-1.1
Na content in liver	0.0	0.0	0.1	0.2	-0.2	0.3	0.2	0.1	-0.1	-0.1	0.1
Rb content in liver	2.7	3.1	4.1	1.4	2.0	1.7	-2.0	-1.9	1.8	1.6	-1.6
Se content in liver	1.1	1.3	2.1	0.1	0.9	1.0	-0.7	-1.4	1.4	1.5	-1.5
Sr content in liver	0.4	0.3	0.8	-0.5	-0.7	-0.9	0.9	0.2	-0.3	-0.3	0.3
Zn content in liver	0.5	0.5	1.1	1.1	0.7	0.8	-0.6	-0.7	0.7	0.6	-0.6
Bone: minimum diameter	10.4	19.0	27.4	-4.8	-5.2	-5.1	5.2	3.5	-3.5	-3.4	3.4
Time in familiar zone, hab. session 1	1.9	1.8	3.1	-0.8	-1.3	-1.1	1.0	1.8	-1.7	-1.4	1.4
Time in novel zone, hab. session 1	2.2	2.2	4.1	0.7	1.5	1.0	-1.3	-2.0	1.9	1.5	-1.5
Total zone transitions, hab. session 1	0.5	0.7	2.4	-1.6	-0.6	-0.8	0.7	-0.6	0.7	0.7	-0.7
Total locomotion distance, hab. session 1	1.0	1.4	4.5	-2.1	-1.1	-1.6	1.2	-0.7	0.7	0.5	-0.5
Locomotion velocity, hab. session 1	1.0	1.4	4.0	-2.0	-1.4	-1.7	1.5	-0.1	0.2	0.0	-0.0
Time in familiar zone, hab. session 2	1.1	1.2	1.9	-0.8	-1.4	-1.3	1.0	1.1	-1.2	-0.9	0.9
Time in novel zone, hab. session 2	0.8	0.8	1.4	0.7	1.1	0.8	-0.7	-1.1	1.2	0.8	-0.8
Total zone transitions, hab. session 2	0.2	0.3	0.6	-0.8	-0.3	-0.6	0.4	-0.4	0.4	0.7	-0.7
Total locomotion distance, hab. session 2	0.7	0.9	2.8	-1.7	-1.1	-1.3	1.2	0.2	-0.2	-0.1	0.1
Locomotion velocity, hab. session 2	0.6	0.8	2.4	-1.5	-1.1	-1.2	1.3	0.2	-0.2	-0.1	0.1
Novel to familiar place preference ratio	0.4	0.4	1.3	-1.1	-0.8	-0.9	0.7	0.1	-0.1	-0.1	0.1
Novelty place preference	0.2	0.2	0.6	-0.8	-0.5	-0.6	0.4	-0.1	0.1	0.1	-0.1
Time in novel zone, NPP test	0.2	0.2	0.5	-0.7	-0.3	-0.5	0.2	-0.4	0.4	0.3	-0.3
Total zone transitions, NPP test	0.7	1.0	2.2	-1.5	-0.3	-0.5	0.6	-1.0	1.0	1.2	-1.2
Total locomotion distance, NPP test	0.8	1.1	3.4	-1.8	-1.1	-1.5	1.3	-0.1	0.1	0.2	-0.2
Locomotion velocity, NPP test	0.7	1.0	3.4	-1.8	-1.0	-1.3	1.4	0.0	-0.1	0.1	-0.1
Intraocular pressure	0.3	0.4	0.8	-0.9	-0.9	-0.6	0.8	0.5	-0.6	-0.3	0.3
Delta distance traveled before/after self-admin	0.3	0.3	0.6	-0.6	0.0	-0.2	-0.2	-0.7	0.7	0.7	-0.7
Delta ambulatory time before/after self-admin	0.1	0.2	0.5	-0.7	-0.5	-0.7	0.4	0.0	-0.0	-0.1	0.1
Parametrial fat weight	0.3	0.6	0.9	0.6	-0.5	-0.5	0.9	0.9	-0.9	-0.9	0.9
Pavlov. Cond. lever latency	0.3	0.4	1.1	1.0	0.7	0.5	-0.8	0.3	-0.3	-0.6	0.6
Pavlov. Cond. magazine entry latency	1.2	1.6	3.0	-1.5	-1.7	-1.4	1.7	0.9	-0.8	-0.7	0.7
Pavlov. Cond. change in total contacts	0.7	0.7	1.5	-1.2	-1.1	-0.8	1.0	0.7	-0.6	-0.4	0.4
Pavlov. Cond. index score	0.8	1.0	2.2	-1.4	-1.5	-1.1	1.4	0.4	-0.4	-0.2	0.2
Pavlov. Cond. latency score	0.6	0.7	1.7	-1.3	-1.3	-1.0	1.3	0.2	-0.2	0.0	-0.0
Pavlov. Cond. lever contacts	0.3	0.3	0.8	-0.8	-0.9	-0.5	0.8	0.4	-0.4	-0.1	0.1
Pavlov. Cond. magazine entry number	0.6	0.8	1.6	0.9	1.3	0.8	-1.3	-0.7	0.6	0.6	-0.6
Pavlov. Cond. intertrial magazine entries	1.6	1.9	6.0	-2.4	-1.4	-1.4	1.5	1.1	-1.1	-0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	2.2	-1.4	-1.5	-1.1	1.4	0.4	-0.4	-0.2	0.2
Pavlov. Cond. response bias	0.9	1.1	2.6	-1.3	-1.5	-1.1	1.6	0.7	-0.6	-0.4	0.4
Pavlov. Cond. lever latency	0.1	0.1	0.4	0.7	0.6	0.3	-0.5	0.0	-0.1	-0.1	0.1
Pavlov. Cond. magazine entry latency	2.2	2.7	4.3	2.1	1.8	1.8	-1.8	-1.4	1.4	1.3	-1.3
Pavlov. Cond. change in total contacts	0.1	0.2	0.4	-0.5	-0.7	-0.3	0.5	0.4	-0.4	-0.5	0.5
Pavlov. Cond. index score	0.1	0.2	0.3	0.4	0.2	0.4	-0.3	-0.5	0.6	0.5	-0.5
Pavlov. Cond. latency score	0.3	0.5	0.7	0.6	0.5	0.6	-0.6	-0.8	0.8	0.8	-0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.6	-0.4	-0.2	0.4	-0.1	0.1	0.1	-0.1
Pavlov. Cond. magazine entry number	3.8	4.6	5.5	-2.3	-2.3	-2.3	2.2	2.0	-2.0	-2.0	2.0
Pavlov. Cond. intertrial magazine entries	12.0	18.1	23.7	-4.0	-4.9	-4.5	4.7	4.1	-4.0	-3.8	3.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	0.5	0.4	0.5	-0.4	-0.6	0.7	0.6	-0.6
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.2	-0.1	0.1	0.1	-0.4	0.5	0.5	-0.5
Time in closed arm before self-admin	0.8	1.1	2.5	-0.4	0.2	0.0	-0.4	-1.3	1.6	1.4	-1.4
Time in closed arm after self-admin	0.4	0.4	0.6	0.6	0.6	0.0	-0.6	-0.5	0.8	0.7	-0.7
Time in open arm before self-admin	1.2	1.3	2.3	1.5	1.5	1.1	-1.1	-1.0	0.6	0.9	-0.9
Time in open arm after self-admin	0.3	0.3	0.6	0.3	-0.2	0.3	0.3	0.5	-0.8	-0.8	0.8
Bone: periosteal estimation	6.6	13.9	22.1	-4.6	-4.7	-4.7	4.5	2.6	-2.6	-2.5	2.5
Bone: periosteal perimeter	2.6	4.5	8.8	-2.9	-2.8	-2.7	3.0	1.1	-1.1	-0.9	0.9
Bone: post-yield work	1.4	2.0	3.4	-1.8	-1.7	-1.8	1.6	0.9	-0.9	-1.1	1.1
Progressive ratio test 1 active lever presses	1.7	2.1	5.8	-2.4	-2.0	-1.9	1.9	0.1	-0.3	-0.3	0.3
Progressive ratio test 1 breakpoint	2.1	2.6	6.7	-2.6	-2.1	-2.1	2.1	0.3	-0.5	-0.5	0.5
Progressive ratio test 1 inactive lever presses	2.3	3.4	8.6	-2.9	-2.2	-2.8	2.2	0.4	-0.3	-0.3	0.3
Progressive ratio test 2 active lever presses	3.3	3.9	7.3	-2.2	-2.6	-2.2	2.7	1.4	-1.4	-1.4	1.4
Progressive ratio test 2 breakpoint	3.8	4.3	7.8	-2.2	-2.7	-2.3	2.8	1.5	-1.5	-1.5	1.5
Progressive ratio test 2 inactive lever presses	1.9	3.0	6.9	-2.6	-2.1	-2.2	2.3	0.9	-0.8	-0.8	0.8
Incentive Sensitization - Responses	1.9	2.7	4.8	-1.3	-2.1	-1.6	2.2	1.5	-1.4	-1.4	1.4
Incentive Sensitization - Breakpoint	2.1	2.8	4.8	-1.2	-2.1	-1.6	2.2	1.5	-1.5	-1.5	1.5
Sum of active levers in priming session hrs 5-6	1.6	1.5	3.0	0.9	1.3	1.7	-1.5	-1.3	0.8	1.0	-1.0
Progressive ratio	0.2	0.2	0.4	0.2	-0.4	-0.2	0.6	0.6	-0.6	-0.6	0.6
Food seeking constrained by brief footshock	2.8	3.5	4.7	-1.0	-2.2	-2.1	1.7	2.0	-2.0	-1.8	1.8
Seeking ratio, punishment vs. effort	0.7	1.0	1.7	-1.3	-1.2	-1.3	0.9	0.9	-0.9	-0.8	0.8
Retroperitoneal fat weight	0.5	2.0	2.9	-1.4	-1.7	-1.7	1.7	1.2	-1.2	-1.2	1.2
Reaction time number correct	0.6	1.1	1.8	0.6	1.0	1.1	-0.5	-1.2	1.3	1.2	-1.2
Reaction time mean minus median	0.2	0.5	1.2	1.1	0.8	0.7	-0.7	0.5	-0.6	-0.6	0.6
Reaction time mean minus median AUC	0.3	0.9	2.0	1.0	1.4	1.2	-1.1	-0.6	0.6	0.6	-0.6
Reaction time num false alarms	1.6	2.3	4.8	-2.2	-2.2	-1.8	2.0	0.8	-0.6	-0.5	0.5
Reaction time num false alarms AUC	1.6	2.6	5.3	-2.2	-2.3	-1.9	2.2	1.0	-0.8	-0.7	0.7
Reaction time trials correct on left	0.6	1.1	1.8	0.6	1.0	1.1	-0.5	-1.2	1.3	1.2	-1.2
Reaction time trials on left	0.5	1.0	1.6	0.6	0.9	1.0	-0.4	-1.2	1.3	1.2	-1.2
Reaction time mean	0.5	0.8	1.9	1.4	1.2	1.1	-1.3	-0.4	0.2	0.2	-0.2
Reaction time mean AUC	0.8	1.3	2.9	1.7	1.5	1.5	-1.7	-0.6	0.3	0.4	-0.4
Median of all reaction times	0.7	0.9	1.9	1.3	1.2	1.1	-1.4	-0.7	0.4	0.6	-0.6
Reaction time omissions	0.5	0.7	1.1	-0.6	-0.6	-1.1	0.7	0.8	-0.9	-1.0	1.0
Reaction time false alarm rate	2.0	2.8	5.2	-1.9	-2.3	-2.0	1.9	1.4	-1.3	-1.1	1.1
Reaction time premature initiation rate	0.6	0.8	3.7	-1.9	-1.0	-0.9	1.0	0.2	-0.1	-0.3	0.3
Reaction time premature initiations	0.2	0.4	1.9	-1.4	-0.6	-0.4	0.8	-0.2	0.3	0.2	-0.2
Std. dev. reaction times	0.3	0.6	1.5	1.2	0.8	0.6	-0.8	0.6	-0.7	-0.7	0.7
Reaction time trials completed	0.5	1.0	1.6	0.6	0.9	1.0	-0.4	-1.2	1.3	1.2	-1.2
Reaction time trials AUC	0.5	1.0	1.6	0.6	0.9	0.9	-0.4	-1.2	1.3	1.1	-1.1
Run reversals in cocaine runway, females	0.2	0.2	0.6	0.7	0.8	0.6	-0.6	-0.2	0.0	0.1	-0.1
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.4	0.5	0.2	-0.2	0.2	-0.2	-0.2	0.2
Latency to leave start box in cocaine runway	0.4	0.4	0.7	0.4	0.5	0.5	-0.7	-0.6	0.8	0.7	-0.7
Latency to leave start box in cocaine runway, F	1.4	1.6	2.6	0.5	1.0	1.0	-1.1	-1.4	1.6	1.5	-1.5
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	0.3	-0.3	-0.2	0.1	0.6	-0.6	-0.6	0.6
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.1	-0.0	0.0	0.1	0.4	-0.4	-0.5	0.5
Total sessions with >9 infusions	0.6	0.8	1.4	-1.0	-0.3	-0.3	0.3	-1.2	1.1	1.1	-1.1
Short access day 1 total inactive lever presses	1.4	1.9	5.1	-2.3	-1.6	-2.1	1.7	0.1	-0.1	-0.1	0.1
Short access day 10 total inactive lever presses	0.1	0.3	1.2	-1.1	-0.2	-0.6	0.4	0.6	-0.4	-0.4	0.4
Short access day 1 total infusions	1.1	1.4	2.4	-1.5	-0.6	-0.5	0.5	-1.5	1.4	1.4	-1.4
Short access day 10 total infusions	2.4	3.1	8.2	-2.9	-2.2	-2.5	2.1	0.4	-0.5	-0.5	0.5
Short access total infusions	1.1	1.4	4.4	-2.1	-1.4	-1.5	1.2	-0.6	0.5	0.5	-0.5
Short access day 1 locomotion	1.5	1.8	7.3	-2.7	-1.5	-1.5	1.6	-0.4	0.2	0.2	-0.2
Short access day 10 total locomotion	2.9	5.4	10.0	-3.2	-2.9	-2.8	2.6	1.7	-1.5	-1.5	1.5
Short access total locomotion	2.2	2.6	8.3	-2.9	-2.0	-2.1	1.9	0.3	-0.4	-0.4	0.4
One hour access (0.3 mA shock)	0.6	0.6	1.5	-0.7	-1.2	-0.9	1.0	0.6	-0.5	-0.5	0.5
Compulsive drug intake	0.9	1.1	1.6	1.2	1.3	1.0	-1.0	-1.1	0.9	0.9	-0.9
One hour access (shock baseline)	1.2	1.9	3.2	-1.5	-1.8	-1.6	1.6	1.2	-1.0	-1.0	1.0
Social response proportion	0.2	0.2	0.4	0.2	0.5	0.5	-0.5	-0.6	0.5	0.4	-0.4
Social responses	0.2	0.3	0.7	-0.7	-0.1	-0.0	-0.0	-0.8	0.7	0.6	-0.6
Social time	0.2	0.3	1.4	1.2	0.4	0.7	-0.4	0.3	-0.4	-0.4	0.4
Soleus weight	0.1	0.2	0.4	-0.3	-0.1	0.2	0.3	-0.6	0.6	0.6	-0.6
Bone: stiffness	0.9	1.4	4.3	-2.1	-1.4	-1.6	1.4	-0.2	0.3	0.3	-0.3
Tibialis anterior weight	0.2	0.8	2.1	-0.5	-0.6	-0.6	0.6	1.5	-1.2	-1.0	1.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	0.8	0.5	0.6	-0.2	0.4	-0.3	-0.5	0.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.1	-0.2	0.1	0.5	0.5	0.1	-0.1	0.1
Time to tail flick, test, before self-admin	0.2	0.2	0.4	0.5	0.5	0.2	-0.7	0.3	-0.4	-0.4	0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.2	-0.0	-0.0	0.1	0.5	-0.4	-0.4	0.4
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	1.7	-0.8	-1.3	-1.2	1.2	1.3	-1.1	-1.0	1.0
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.1	-0.2	0.0	0.3	0.2	-0.0	-0.0	0.0
Tibia length	0.5	1.5	3.3	-0.5	0.1	0.1	0.3	-1.6	1.6	1.8	-1.8
Ambulatory time before self-admin	0.5	0.7	1.0	0.9	0.8	1.0	-0.8	-0.8	0.8	0.8	-0.8
Ambulatory time after self-admin	0.1	0.2	0.4	-0.3	0.2	0.1	-0.2	-0.6	0.5	0.5	-0.5
Bone: tissue strength	1.7	1.7	2.8	0.5	0.9	0.9	-0.8	-1.7	1.7	1.7	-1.7
Total heroin consumption	0.2	0.2	0.5	-0.1	-0.3	0.2	-0.0	-0.6	0.7	0.6	-0.6
Bone: trabecular number	0.9	1.5	3.3	-1.5	-1.5	-1.5	1.8	0.7	-0.7	-0.7	0.7
Bone: trabecular spacing	0.3	0.3	1.1	1.1	0.6	0.6	-0.9	0.1	-0.1	-0.1	0.1
Bone: trabecular thickness	1.3	1.6	3.0	-1.4	-1.3	-1.2	1.7	1.0	-1.0	-1.1	1.1
Bone: trabecular tissue density	1.0	1.5	2.6	-0.5	0.9	0.7	-0.2	-1.6	1.6	1.6	-1.6
Water consumed over 24 hours	0.2	0.2	0.7	-0.6	-0.4	-0.8	0.4	-0.4	0.3	0.3	-0.3
Number of responses in last shaping day	0.0	0.0	0.1	-0.2	-0.0	0.1	0.1	-0.2	0.1	0.1	-0.1