Hub : Genes

Polg2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Polg2 0.04 0.02 6.4e-05 0.04 0.04 0.04 0.03 7.9e-05 4.7e-05 2.8e-05 3.1e-04
2 pVTA gene expression Polg2 0.07 0.05 2.2e-03 0.03 0.03 0.04 0.04 3.8e-03 1.6e-03 3.3e-04 4.1e-04
3 NAcc gene expression Polg2 0.02 0.01 7.2e-04 0.03 0.02 0.02 0.02 4.4e-05 9.1e-04 1.4e-04 3.4e-04
4 Liver alternative TSS NM_001107060.1 0.04 0.02 1.9e-05 0.02 0.04 0.01 0.02 1.8e-03 7.2e-05 1.1e-02 1.9e-03
5 Adipose alternative TSS XM_063269211.1 0.03 0.02 2.2e-03 0.03 0.01 0 0.01 5.7e-04 1.1e-02 2.0e-01 1.3e-02
6 Adipose alternative TSS NM_001107060.1 0.03 0.02 5.5e-04 0.03 0.02 0.01 0.02 9.2e-05 1.8e-03 1.1e-02 1.3e-03
7 Adipose alternative TSS NM_001107060.1 0.03 0.02 2.5e-03 0.03 0.02 0 0.01 7.5e-04 5.5e-03 1.8e-01 8.9e-03
8 Adipose alternative TSS XM_063269212.1 0.03 0.02 5.4e-03 0.02 0.01 0 0.01 1.2e-03 2.0e-02 3.2e-01 2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.30.51.60.80.71.01.3-0.30.20.3-0.3
Area under the delay curve0.00.10.40.20.0-0.10.6-0.20.10.3-0.3
BMI with tail1.03.615.31.93.92.42.00.0-0.2-0.40.4
BMI without tail1.47.225.83.25.13.33.2-0.40.40.3-0.3
Body weight2.711.823.34.34.84.44.4-2.01.91.7-1.7
Weight adjusted by age0.20.51.0-0.8-1.0-1.0-0.70.4-0.5-0.50.5
Bone surface2.75.310.33.01.93.13.2-1.61.61.5-1.5
Bone volume2.14.28.52.61.82.72.9-1.41.41.4-1.4
Breakpoint value in progressive ratio session0.20.30.6-0.2-0.8-0.4-0.60.6-0.5-0.50.5
Number of licking bursts0.00.10.4-0.1-0.6-0.2-0.20.1-0.0-0.00.0
Context. condit. distance diff. score0.10.10.3-0.20.5-0.2-0.20.5-0.5-0.30.3
Locomotion velocity, session 10.50.61.40.91.01.11.2-0.20.20.3-0.3
Locomotion distance, session 10.50.62.70.51.70.90.80.5-0.5-0.40.4
Locomotion velocity, session 20.10.20.60.60.50.80.20.00.00.1-0.1
Locomotion distance, session 20.50.71.50.00.70.20.00.9-0.9-1.21.2
Locomotion velocity, session 31.21.42.4-0.90.3-0.8-0.71.5-1.6-1.51.5
Locomotion distance, session 30.10.20.3-0.00.20.1-0.00.6-0.6-0.60.6
Stereotopy head waving bouts, day 30.40.51.0-1.0-0.8-1.0-0.60.6-0.6-0.50.5
Stereotopy head waving duration, day 30.50.61.2-0.9-0.9-1.1-0.60.7-0.7-0.50.5
Locomotion velocity, session 70.40.40.6-0.70.1-0.3-0.70.7-0.8-0.80.8
Locomotion distance, session 70.00.00.20.10.40.2-0.10.0-0.10.1-0.1
Stereotopy head waving bouts, day 71.41.62.3-1.4-1.4-1.5-1.21.1-1.1-1.31.3
Stereotopy head waving duration, day 72.83.45.3-2.1-2.3-2.3-1.91.4-1.3-1.61.6
Locomotion velocity, session 80.30.40.90.90.61.00.7-0.40.50.3-0.3
Locomotion distance, session 80.20.30.80.30.90.30.20.5-0.5-0.60.6
Degree of sensitization distance0.60.71.10.70.40.70.7-0.90.91.0-1.0
Degree of sensitization stereotypy2.12.33.0-1.5-0.9-1.5-1.61.6-1.5-1.71.7
Conditioned locomotion0.40.50.90.70.50.50.6-1.00.90.6-0.6
Cocaine response after cond. corrected0.30.51.9-0.8-1.4-0.8-0.50.3-0.3-0.50.5
Cocaine response after cond. not corrected0.91.33.9-1.2-2.0-1.2-1.00.7-0.8-0.80.8
Cocaine response before conditioning0.40.50.8-0.6-0.3-0.6-0.70.9-0.9-0.70.7
Saline control response0.71.01.41.11.00.70.7-1.11.21.0-1.0
Bone: connectivity density0.81.33.01.51.01.61.7-0.60.60.7-0.7
Bone: cortical apparent density2.74.25.9-2.3-0.1-1.9-1.82.4-2.4-2.22.2
Bone: cortical area1.42.39.01.13.01.51.40.9-0.9-1.11.1
Bone: cortical porosity1.11.22.71.70.41.41.3-1.01.00.7-0.7
Bone: cortical porosity0.91.02.41.50.91.31.5-0.50.50.3-0.3
Bone: cortical thickness8.614.322.9-3.31.3-2.5-2.64.6-4.7-4.84.8
Bone: cortical thickness5.66.911.0-2.21.3-1.7-2.13.1-3.1-3.33.3
Bone: cortical tissue density2.54.05.4-2.3-0.2-1.9-1.92.3-2.3-2.12.1
Condit. Reinf. active minus inactive responses1.01.11.51.21.20.91.2-1.01.00.8-0.8
Condit. Reinf. active-inactive response ratio0.20.20.40.50.20.20.5-0.60.60.6-0.6
Condit. Reinf. active responses1.72.23.01.71.61.41.7-1.41.51.1-1.1
Condit. Reinf. inactive responses1.11.42.31.51.41.41.5-0.91.00.7-0.7
Incentive salience index mean0.60.81.31.11.00.81.1-0.90.90.6-0.6
Condit. Reinf. lever presses0.00.00.10.20.1-0.20.1-0.30.30.1-0.1
Condit. Reinf. active minus inactive responses1.82.86.32.52.02.02.4-0.80.80.5-0.5
Condit. Reinf. active-inactive response ratio0.60.92.01.40.20.81.4-1.01.00.6-0.6
Condit. Reinf. active responses3.65.210.83.32.92.72.9-1.41.41.2-1.2
Condit. Reinf. inactive responses2.33.411.02.33.32.31.9-0.70.70.7-0.7
Condit. Reinf. lever presses1.01.45.01.72.21.41.3-0.30.30.2-0.2
Condit. Reinf. lever reinforcers received3.24.59.13.02.72.52.7-1.31.31.1-1.1
Conditioned reinforcement - actives0.10.30.70.90.60.50.9-0.20.40.4-0.4
Conditioned reinforcement - inactives0.61.54.11.41.82.01.4-0.40.50.5-0.5
Conditioned locomotion2.13.14.32.01.91.92.1-1.51.51.5-1.5
Patch foraging indifference point 0 sec2.16.014.63.03.83.03.0-1.51.41.3-1.3
Patch foraging indifference point AUC0.61.52.61.61.51.51.5-0.70.80.9-0.9
Delay disc. indifference point, 0s delay0.40.41.9-0.7-1.4-0.9-0.4-0.10.20.2-0.2
Delay disc. indifference point, 16s delay0.10.20.80.50.20.10.9-0.10.10.2-0.2
Delay disc. indifference point, 2s delay0.70.82.10.90.20.71.4-0.90.80.9-0.9
Delay disc. indifference point, 24s delay1.01.64.01.62.01.31.9-0.50.30.6-0.6
Delay disc. indifference point, 4s delay0.60.71.3-1.1-1.0-1.1-0.80.6-0.7-0.50.5
Delay disc. indifference point, 8s delay0.00.00.2-0.3-0.2-0.40.20.1-0.00.0-0.0
Indifference point function ln k0.51.52.4-1.10.2-1.1-0.91.4-1.4-1.51.5
Indifference point function log k0.51.52.4-1.10.2-1.1-0.91.4-1.4-1.51.5
Patch foraging total patch changes 0 sec2.16.314.23.03.83.03.1-1.61.51.3-1.3
Patch foraging total patch changes 12 sec6.48.611.63.42.73.33.2-2.82.62.7-2.7
Patch foraging total patch changes 18 sec1.53.66.12.52.42.42.0-1.31.31.3-1.3
Patch foraging total patch changes 24 sec1.44.811.12.83.32.72.8-1.11.11.1-1.1
Patch foraging total patch changes 6 sec2.44.19.62.43.12.82.4-1.01.01.0-1.0
Patch foraging time to switch 0 sec0.20.83.1-1.1-1.8-0.9-1.1-0.30.20.2-0.2
Patch foraging water rate 0 sec0.93.49.92.33.22.42.2-0.70.60.6-0.6
Patch foraging water rate 12 sec0.62.44.8-0.90.6-0.5-0.82.2-2.0-2.02.0
Patch foraging water rate 18 sec0.61.42.7-0.20.70.00.01.6-1.6-1.61.6
Patch foraging water rate 24 sec0.20.20.5-0.1-0.3-0.1-0.00.6-0.6-0.70.7
Patch foraging water rate 6 sec0.40.51.0-0.00.7-0.10.21.0-1.0-0.90.9
Seeking ratio, delayed vs. immediate footshock0.00.10.40.20.6-0.00.00.1-0.2-0.10.1
Distance traveled before self-admin0.61.31.8-1.2-1.3-1.3-1.10.9-1.0-1.11.1
Distance traveled after self-admin0.20.30.6-0.4-0.5-0.4-0.50.8-0.6-0.60.6
Extensor digitorum longus weight0.41.42.8-1.7-1.2-1.7-1.7-0.90.70.5-0.5
Bone: elastic displacement3.03.85.5-1.9-0.5-1.7-1.62.4-2.2-2.32.3
Bone: elastic work0.81.12.1-0.21.50.20.01.3-1.1-1.31.3
Bone: endosteal estimation10.826.439.16.32.96.05.6-4.95.04.9-4.9
Bone: endosteal perimeter11.327.742.06.53.26.16.2-4.94.94.8-4.8
Epididymis fat weight0.31.31.91.31.01.31.4-1.01.11.1-1.1
Delta time in closed arm before/after self-admin0.20.10.4-0.3-0.2-0.0-0.2-0.50.60.4-0.4
Delta time in open arm before/after self-admin0.10.10.3-0.0-0.5-0.5-0.1-0.20.30.5-0.5
Diff in mean of infusions in LGA sessions1.22.23.3-1.8-0.6-1.5-1.81.4-1.4-1.51.5
Delay discount exponential model param0.10.20.7-0.3-0.2-0.1-0.80.3-0.3-0.40.4
Extinction: sum of active levers before priming0.00.00.30.00.5-0.2-0.1-0.00.10.0-0.0
Active lever presses in extinction session 60.90.92.41.01.50.90.9-0.60.70.9-0.9
Bone: final force0.91.43.20.91.81.41.11.0-1.0-1.01.0
Bone: final moment0.91.53.30.81.81.31.11.0-1.1-1.11.1
Food consumed during 24 hour testing period1.53.04.52.11.62.12.1-1.41.51.4-1.4
Glucose1.11.82.3-1.3-1.2-1.5-1.51.2-1.2-1.31.3
Heart weight0.40.71.3-0.6-0.1-0.8-0.10.9-1.0-1.11.1
Delay discount hyperbolic model param0.20.20.7-0.4-0.1-0.1-0.80.5-0.4-0.50.5
Intermittent access intake day 1-15 change0.00.30.50.0-0.4-0.1-0.3-0.70.70.7-0.7
Intermittent access intake escalation0.10.50.90.40.10.30.2-0.90.90.9-0.9
Intermittent access intake escalation 20.71.22.30.70.10.60.4-1.51.51.5-1.5
Intermitt. access day 1 inactive lever presses0.22.33.71.91.71.81.6-1.31.11.1-1.1
Intermitt. access day 15 inactive lever presses0.31.52.21.11.51.51.0-1.31.11.1-1.1
Intermitt. access escalation Index1.23.95.5-2.4-2.2-2.2-2.01.6-1.7-1.71.7
Intermittent access day 1 total infusions0.31.02.81.11.71.31.20.5-0.5-0.50.5
Intermittent access day 15 total infusions0.51.32.31.51.51.31.5-0.70.70.7-0.7
Intermittent access terminal intake (last 3 days)1.93.34.92.21.82.22.2-1.41.41.4-1.4
Intermittent access total infusions2.22.65.52.12.32.22.2-0.60.60.6-0.6
Intermittent access day 1 locomotion1.52.88.82.03.02.22.1-0.30.20.2-0.2
Intermittent access day 15 total locomotion1.45.49.93.03.12.82.8-1.31.41.4-1.4
Intermittent access total locomotion6.27.519.83.44.53.53.3-1.11.11.1-1.1
Intermittent access standard deviation0.21.22.11.31.51.31.0-0.90.80.8-0.8
Left kidney weight0.32.75.6-0.21.10.0-0.12.4-2.2-2.22.2
Right kidney weight0.32.14.30.00.7-0.00.42.1-2.0-1.91.9
Cocaine induced anxiety0.61.62.5-1.0-0.0-0.9-0.91.6-1.6-1.61.6
Post-drug Anxiety1.21.32.0-1.00.1-0.9-0.81.4-1.4-1.41.4
Baseline Anxiety0.00.00.0-0.20.0-0.2-0.1-0.20.20.2-0.2
Tail length1.58.013.73.73.23.43.5-2.02.02.1-2.1
Length with tail2.19.114.03.71.93.33.7-2.72.72.8-2.8
Length without tail0.42.03.21.2-0.21.11.3-1.81.81.6-1.6
Times rat made contact with spout0.50.51.11.00.21.00.9-0.60.70.6-0.6
Lifetime Intake2.32.97.22.32.72.32.2-0.40.40.4-0.4
Liver weight, left1.93.27.02.71.52.32.5-1.21.11.1-1.1
Liver weight, right1.62.86.1-0.90.6-0.5-0.72.5-2.4-2.12.1
Locomotor activity1.21.94.30.82.10.80.51.4-1.5-1.51.5
Locomotor testing distance0.61.44.41.02.10.70.51.0-1.1-1.21.2
Locomotor testing rearing0.10.41.80.91.40.80.10.1-0.2-0.00.0
Locomotion in novel chamber0.10.20.4-0.4-0.7-0.1-0.10.4-0.5-0.30.3
Locomotion in novel chamber post-restriction0.82.53.81.70.51.82.0-1.51.51.6-1.6
Fecal boli incidents, locomotor time 10.20.51.2-0.2-1.1-0.4-0.1-0.80.80.8-0.8
Change in fecal boli incidents, locomotor task0.20.20.30.30.50.40.4-0.50.40.4-0.4
Time >=10cm from walls, locomotor time 12.12.63.4-1.3-1.8-1.2-1.71.6-1.8-1.61.6
Bouts of movement, locomotor time 10.10.10.4-0.60.1-0.3-0.50.2-0.2-0.20.2
Total resting periods, locomotor time 10.00.10.3-0.50.0-0.2-0.40.00.00.0-0.0
Rest time, locomotor task time 10.40.62.1-0.4-1.4-0.4-0.3-0.70.90.7-0.7
Distance moved, locomotor task time 10.20.51.30.81.20.90.9-0.10.10.0-0.0
Vertical activity count, locomotor time 10.00.20.60.60.80.60.60.1-0.2-0.20.2
Time >=10cm from walls, locomotor time 20.20.51.6-0.6-1.3-0.4-0.90.5-0.7-0.50.5
Bouts of movement, locomotor time 20.00.10.4-0.5-0.1-0.5-0.60.1-0.3-0.20.2
Total resting periods, locomotor time 20.10.30.8-0.8-0.3-0.8-0.90.3-0.4-0.40.4
Rest time, locomotor task time 21.93.29.1-2.2-3.0-2.3-2.00.7-0.6-0.80.8
Distance moved, locomotor task time 20.30.41.10.71.01.10.5-0.20.10.2-0.2
Vertical activity count, locomotor time 20.71.63.91.62.01.71.2-0.70.60.8-0.8
Light reinforcement 10.10.52.80.31.70.10.60.3-0.4-0.30.3
Light reinforcement 20.10.30.90.70.90.40.9-0.20.20.2-0.2
Bone: marrow area10.325.337.66.12.85.85.5-4.84.94.8-4.8
Bone: maximum diameter2.85.610.13.12.63.13.2-1.61.51.4-1.4
Bone: maximum force1.32.68.21.82.92.22.10.4-0.4-0.40.4
Bone: maximum moment1.42.68.11.72.92.22.00.4-0.4-0.50.5
Mean time between licks in bursts0.10.40.80.70.20.70.9-0.60.60.6-0.6
Mean num. licks in bursts0.10.40.60.70.80.70.8-0.50.60.4-0.4
Cd content in liver1.92.16.2-2.0-2.5-1.8-1.80.00.10.4-0.4
Co content in liver0.91.02.1-1.3-1.4-1.3-1.20.7-0.6-0.40.4
Cu content in liver0.50.61.30.6-0.20.40.4-1.21.11.0-1.0
Fe content in liver0.10.10.20.10.10.1-0.30.3-0.5-0.40.4
K content in liver0.20.20.50.7-0.30.50.7-0.20.30.2-0.2
Mg content in liver0.30.31.4-0.5-1.2-0.6-0.50.0-0.00.2-0.2
Mn content in liver0.60.71.4-0.20.1-0.0-0.11.2-1.2-1.11.1
Na content in liver0.10.10.50.2-0.7-0.30.2-0.10.10.1-0.1
Rb content in liver2.73.14.1-2.0-1.4-1.7-2.01.9-1.8-1.61.6
Se content in liver1.11.32.1-0.9-0.3-1.0-0.71.4-1.4-1.51.5
Sr content in liver0.40.30.80.70.50.90.9-0.20.30.3-0.3
Zn content in liver0.50.61.3-0.7-1.1-0.8-0.60.7-0.7-0.60.6
Bone: minimum diameter9.318.027.45.23.85.15.2-3.53.53.4-3.4
Time in familiar zone, hab. session 11.61.73.11.30.41.11.0-1.81.71.4-1.4
Time in novel zone, hab. session 11.92.14.1-1.5-0.1-1.0-1.32.0-1.9-1.51.5
Total zone transitions, hab. session 10.60.93.60.61.90.80.70.6-0.7-0.70.7
Total locomotion distance, hab. session 11.21.66.41.12.51.61.20.7-0.7-0.50.5
Locomotion velocity, hab. session 11.11.55.01.42.21.71.50.1-0.2-0.00.0
Time in familiar zone, hab. session 21.01.21.91.40.71.31.0-1.11.20.9-0.9
Time in novel zone, hab. session 20.70.81.4-1.1-0.6-0.8-0.71.1-1.2-0.80.8
Total zone transitions, hab. session 20.30.41.10.31.10.60.40.4-0.4-0.70.7
Total locomotion distance, hab. session 20.81.03.71.11.91.31.2-0.20.20.1-0.1
Locomotion velocity, hab. session 20.70.92.91.11.71.21.3-0.20.20.1-0.1
Novel to familiar place preference ratio0.30.41.20.81.10.90.7-0.10.10.1-0.1
Novelty place preference0.10.20.70.50.80.60.40.1-0.1-0.10.1
Time in novel zone, NPP test0.20.20.70.30.80.50.20.4-0.4-0.30.3
Total zone transitions, NPP test0.71.12.70.31.60.50.61.0-1.0-1.21.2
Total locomotion distance, NPP test0.91.24.21.12.01.51.30.1-0.1-0.20.2
Locomotion velocity, NPP test0.81.14.21.02.01.31.4-0.00.1-0.10.1
Intraocular pressure0.30.51.10.91.10.60.8-0.50.60.3-0.3
Delta distance traveled before/after self-admin0.30.30.6-0.00.80.2-0.20.7-0.7-0.70.7
Delta ambulatory time before/after self-admin0.10.20.60.50.70.70.4-0.00.00.1-0.1
Parametrial fat weight0.30.71.00.5-1.00.50.9-0.90.90.9-0.9
Pavlov. Cond. lever latency0.30.41.2-0.7-1.1-0.5-0.8-0.30.30.6-0.6
Pavlov. Cond. magazine entry latency1.21.53.01.71.31.41.7-0.90.80.7-0.7
Pavlov. Cond. change in total contacts0.70.71.61.11.30.81.0-0.70.60.4-0.4
Pavlov. Cond. index score0.70.92.21.51.21.11.4-0.40.40.2-0.2
Pavlov. Cond. latency score0.60.71.71.31.11.01.3-0.20.2-0.00.0
Pavlov. Cond. lever contacts0.30.30.80.90.80.50.8-0.40.40.1-0.1
Pavlov. Cond. magazine entry number0.60.71.6-1.3-0.6-0.8-1.30.7-0.6-0.60.6
Pavlov. Cond. intertrial magazine entries1.51.85.01.42.21.41.5-1.11.10.8-0.8
Pavlov. Cond. lever-magazine prob. diff.0.70.92.21.51.21.11.4-0.40.40.2-0.2
Pavlov. Cond. response bias0.91.12.61.51.11.11.6-0.70.60.4-0.4
Pavlov. Cond. lever latency0.10.10.3-0.6-0.5-0.3-0.5-0.00.10.1-0.1
Pavlov. Cond. magazine entry latency2.02.84.8-1.8-2.2-1.8-1.81.4-1.4-1.31.3
Pavlov. Cond. change in total contacts0.10.20.40.70.20.30.5-0.40.40.5-0.5
Pavlov. Cond. index score0.10.20.3-0.2-0.5-0.4-0.30.5-0.6-0.50.5
Pavlov. Cond. latency score0.30.50.7-0.5-0.7-0.6-0.60.8-0.8-0.80.8
Pavlov. Cond. lever contacts0.10.10.20.40.50.20.40.1-0.1-0.10.1
Pavlov. Cond. magazine entry number3.54.65.52.32.32.32.2-2.02.02.0-2.0
Pavlov. Cond. intertrial magazine entries8.017.623.74.93.54.54.7-4.14.03.8-3.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.4-0.6-0.5-0.40.6-0.7-0.60.6
Pavlov. Cond. response bias0.10.10.20.10.0-0.10.10.4-0.5-0.50.5
Time in closed arm before self-admin0.71.12.5-0.20.8-0.0-0.41.3-1.6-1.41.4
Time in closed arm after self-admin0.30.40.6-0.6-0.4-0.0-0.60.5-0.8-0.70.7
Time in open arm before self-admin1.01.22.1-1.5-1.3-1.1-1.11.0-0.6-0.90.9
Time in open arm after self-admin0.30.30.60.2-0.5-0.30.3-0.50.80.8-0.8
Bone: periosteal estimation5.513.022.14.73.74.74.5-2.62.62.5-2.5
Bone: periosteal perimeter2.14.18.82.82.12.73.0-1.11.10.9-0.9
Bone: post-yield work1.11.93.41.71.61.81.6-0.90.91.1-1.1
Progressive ratio test 1 active lever presses1.22.26.32.02.51.91.9-0.10.30.3-0.3
Progressive ratio test 1 breakpoint1.52.67.12.12.72.12.1-0.30.50.5-0.5
Progressive ratio test 1 inactive lever presses1.33.59.92.23.12.82.2-0.40.30.3-0.3
Progressive ratio test 2 active lever presses2.63.77.32.61.92.22.7-1.41.41.4-1.4
Progressive ratio test 2 breakpoint3.24.17.82.71.92.32.8-1.51.51.5-1.5
Progressive ratio test 2 inactive lever presses1.03.17.22.12.72.22.3-0.90.80.8-0.8
Incentive Sensitization - Responses0.92.64.82.10.81.62.2-1.51.41.4-1.4
Incentive Sensitization - Breakpoint1.22.64.82.10.71.62.2-1.51.51.5-1.5
Sum of active levers in priming session hrs 5-61.51.53.0-1.3-0.8-1.7-1.51.3-0.8-1.01.0
Progressive ratio0.10.30.50.4-0.70.20.6-0.60.60.6-0.6
Food seeking constrained by brief footshock2.73.44.72.20.72.11.7-2.02.01.8-1.8
Seeking ratio, punishment vs. effort0.51.12.31.21.51.30.9-0.90.90.8-0.8
Retroperitoneal fat weight0.42.02.91.71.41.71.7-1.21.21.2-1.2
Reaction time number correct0.31.11.8-1.0-0.8-1.1-0.51.2-1.3-1.21.2
Reaction time mean minus median0.10.50.9-0.8-1.0-0.7-0.7-0.50.60.6-0.6
Reaction time mean minus median AUC0.10.92.0-1.4-0.9-1.2-1.10.6-0.6-0.60.6
Reaction time num false alarms1.22.14.82.21.71.82.0-0.80.60.5-0.5
Reaction time num false alarms AUC1.02.35.32.31.61.92.2-1.00.80.7-0.7
Reaction time trials correct on left0.31.11.8-1.0-0.8-1.1-0.51.2-1.3-1.21.2
Reaction time trials on left0.31.01.6-0.9-0.7-1.0-0.41.2-1.3-1.21.2
Reaction time mean0.40.81.9-1.2-1.4-1.1-1.30.4-0.2-0.20.2
Reaction time mean AUC0.51.32.9-1.5-1.6-1.5-1.70.6-0.3-0.40.4
Median of all reaction times0.60.91.9-1.2-1.3-1.1-1.40.7-0.4-0.60.6
Reaction time omissions0.40.71.10.60.61.10.7-0.80.91.0-1.0
Reaction time false alarm rate1.92.65.22.31.52.01.9-1.41.31.1-1.1
Reaction time premature initiation rate0.60.94.31.02.10.91.0-0.20.10.3-0.3
Reaction time premature initiations0.10.41.90.61.40.40.80.2-0.3-0.20.2
Std. dev. reaction times0.20.61.4-0.8-1.2-0.6-0.8-0.60.70.7-0.7
Reaction time trials completed0.31.01.6-0.9-0.7-1.0-0.41.2-1.3-1.21.2
Reaction time trials AUC0.31.01.6-0.9-0.7-0.9-0.41.2-1.3-1.11.1
Run reversals in cocaine runway, females0.20.20.6-0.8-0.4-0.6-0.60.2-0.0-0.10.1
Run reversals in cocaine runway, males0.10.10.2-0.5-0.3-0.2-0.2-0.20.20.2-0.2
Latency to leave start box in cocaine runway0.30.40.7-0.5-0.2-0.5-0.70.6-0.8-0.70.7
Latency to leave start box in cocaine runway, F1.21.52.6-1.0-0.1-1.0-1.11.4-1.6-1.51.5
Latency to leave start box in cocaine runway, M0.20.20.40.3-0.40.20.1-0.60.60.6-0.6
Std. dev. time between licks in bursts0.10.10.20.00.3-0.00.1-0.40.40.5-0.5
Total sessions with >9 infusions0.70.91.50.31.20.30.31.2-1.1-1.11.1
Short access day 1 total inactive lever presses1.12.27.11.62.72.11.7-0.10.10.1-0.1
Short access day 10 total inactive lever presses0.10.52.30.21.50.60.4-0.60.40.4-0.4
Short access day 1 total infusions0.81.53.40.61.80.50.51.5-1.4-1.41.4
Short access day 10 total infusions1.93.28.82.23.02.52.1-0.40.50.5-0.5
Short access total infusions1.01.55.11.42.31.51.20.6-0.5-0.50.5
Short access day 1 locomotion1.22.08.61.52.91.51.60.4-0.2-0.20.2
Short access day 10 total locomotion1.35.410.22.93.22.82.6-1.71.51.5-1.5
Short access total locomotion1.82.89.82.03.12.11.9-0.30.40.4-0.4
One hour access (0.3 mA shock)0.50.61.51.20.50.91.0-0.60.50.5-0.5
Compulsive drug intake0.71.11.6-1.3-1.1-1.0-1.01.1-0.9-0.90.9
One hour access (shock baseline)0.71.83.21.81.21.61.6-1.21.01.0-1.0
Social response proportion0.20.20.4-0.5-0.2-0.5-0.50.6-0.5-0.40.4
Social responses0.30.30.70.10.90.0-0.00.8-0.7-0.60.6
Social time0.30.42.1-0.4-1.5-0.7-0.4-0.30.40.4-0.4
Soleus weight0.10.20.40.10.2-0.20.30.6-0.6-0.60.6
Bone: stiffness0.61.22.51.41.51.61.40.2-0.3-0.30.3
Tibialis anterior weight0.20.92.10.60.70.60.6-1.51.21.0-1.0
Time to tail flick, vehicle, before self-admin0.30.41.7-0.5-1.3-0.6-0.2-0.40.30.5-0.5
Time to tail flick, vehicle, after self-admin0.00.10.30.2-0.4-0.10.5-0.5-0.10.1-0.1
Time to tail flick, test, before self-admin0.20.20.4-0.5-0.4-0.2-0.7-0.30.40.4-0.4
Time to tail flick, test, after self-admin0.10.10.20.00.00.00.1-0.50.40.4-0.4
Delta time to tail flick, vehicle, before/after SA1.21.21.71.30.61.21.2-1.31.11.0-1.0
Delta time to tail flick, test, before/after SA0.00.00.10.2-0.3-0.00.3-0.20.00.0-0.0
Tibia length0.51.53.3-0.10.4-0.10.31.6-1.6-1.81.8
Ambulatory time before self-admin0.20.71.0-0.8-1.0-1.0-0.80.8-0.8-0.80.8
Ambulatory time after self-admin0.10.20.4-0.20.3-0.1-0.20.6-0.5-0.50.5
Bone: tissue strength1.71.72.8-0.9-0.6-0.9-0.81.7-1.7-1.71.7
Total heroin consumption0.20.20.50.3-0.3-0.2-0.00.6-0.7-0.60.6
Bone: trabecular number0.71.33.31.51.01.51.8-0.70.70.7-0.7
Bone: trabecular spacing0.20.30.8-0.6-0.9-0.6-0.9-0.10.10.1-0.1
Bone: trabecular thickness1.11.53.01.31.31.21.7-1.01.01.1-1.1
Bone: trabecular tissue density0.91.52.6-0.90.6-0.7-0.21.6-1.6-1.61.6
Water consumed over 24 hours0.10.20.70.40.60.80.40.4-0.3-0.30.3
Number of responses in last shaping day0.00.00.20.00.4-0.10.10.2-0.1-0.10.1