Hub : Genes

Polg2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Polg2	0.13	0.1	4.7e-03	0.03	0.04	0.03	0.04	1.6e-02	9.3e-03	2.2e-02	1.1e-02
2	PL	gene expression	Polg2	0.04	0.02	6.1e-05	0.04	0.04	0.03	0.04	5.3e-05	3.6e-05	8.0e-04	7.4e-05
3	Adipose	gene expression	Polg2	0.03	0.02	4.4e-03	0.01	0.01	0	0.01	1.0e-02	1.3e-02	2.6e-01	3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.0	1.6	2.4	-1.1	-1.1	1.5
Area under the delay curve	0.1	0.1	0.2	0.1	-0.4	-0.0
BMI with tail	1.4	4.4	8.0	-2.8	-2.1	0.8
BMI without tail	5.3	10.9	16.3	-4.0	-3.5	2.0
Body weight	4.2	17.6	22.6	-4.8	-4.2	3.6
Weight adjusted by age	1.0	1.1	1.4	1.1	0.7	-1.2
Bone surface	4.6	8.0	12.2	-2.5	-2.4	3.5
Bone volume	4.2	7.1	9.8	-2.4	-2.3	3.1
Breakpoint value in progressive ratio session	0.2	0.3	0.5	-0.7	-0.5	0.3
Number of licking bursts	0.1	0.1	0.1	0.2	0.4	-0.1
Context. condit. distance diff. score	0.0	0.0	0.1	-0.3	-0.0	-0.1
Locomotion velocity, session 1	0.9	1.0	1.4	-1.2	-0.9	0.9
Locomotion distance, session 1	1.0	1.2	2.3	-1.5	-1.0	0.7
Locomotion velocity, session 2	0.5	0.6	1.3	-1.1	-0.3	0.7
Locomotion distance, session 2	0.4	0.5	1.4	-1.2	-0.3	0.1
Locomotion velocity, session 3	0.3	0.4	0.6	-0.8	0.3	-0.7
Locomotion distance, session 3	0.1	0.1	0.3	-0.5	0.1	0.1
Stereotopy head waving bouts, day 3	0.4	0.5	0.7	0.7	0.6	-0.9
Stereotopy head waving duration, day 3	0.4	0.5	0.9	0.6	0.5	-0.9
Locomotion velocity, session 7	0.1	0.1	0.3	0.3	0.5	-0.2
Locomotion distance, session 7	0.0	0.0	0.1	-0.1	-0.2	-0.0
Stereotopy head waving bouts, day 7	0.7	0.8	1.4	0.2	0.9	-1.2
Stereotopy head waving duration, day 7	3.1	3.7	4.5	1.5	2.1	-2.1
Locomotion velocity, session 8	0.5	0.6	1.2	-0.6	-0.5	1.1
Locomotion distance, session 8	0.3	0.4	1.0	-1.0	-0.5	0.3
Degree of sensitization distance	0.2	0.2	0.5	0.1	-0.7	0.4
Degree of sensitization stereotypy	1.1	1.3	2.1	0.0	1.3	-1.5
Conditioned locomotion	0.2	0.3	0.7	-0.2	-0.8	0.3
Cocaine response after cond. corrected	1.4	1.6	2.7	1.7	1.1	-0.9
Cocaine response after cond. not corrected	2.7	3.0	3.6	1.9	1.9	-1.3
Cocaine response before conditioning	0.3	0.4	0.7	-0.2	0.8	-0.6
Saline control response	1.5	1.9	2.7	-1.7	-1.6	0.6
Bone: connectivity density	1.5	2.4	3.5	-1.3	-1.3	1.9
Bone: cortical apparent density	1.2	1.6	3.1	0.7	1.1	-1.7
Bone: cortical area	5.4	8.2	13.7	-3.7	-2.4	2.2
Bone: cortical porosity	3.0	3.3	4.7	-2.2	-1.4	1.9
Bone: cortical porosity	2.7	2.9	5.2	-2.3	-1.2	1.4
Bone: cortical thickness	1.0	1.7	2.6	-1.4	0.7	-1.6
Bone: cortical thickness	1.0	1.2	1.8	-0.9	1.0	-1.3
Bone: cortical tissue density	1.3	1.7	3.1	0.8	1.2	-1.8
Condit. Reinf. active minus inactive responses	1.8	2.0	2.9	-1.7	-1.5	0.9
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.4	-0.6	-0.6	0.3
Condit. Reinf. active responses	2.7	3.3	4.0	-2.0	-1.9	1.4
Condit. Reinf. inactive responses	1.7	2.0	2.2	-1.4	-1.5	1.4
Incentive salience index mean	1.4	1.7	2.7	-1.6	-1.2	0.9
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.5	-0.0	-0.1
Condit. Reinf. active minus inactive responses	5.0	6.2	9.3	-3.1	-2.3	2.0
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.1	-1.1	-0.9	0.8
Condit. Reinf. active responses	7.0	9.7	12.8	-3.6	-3.1	2.6
Condit. Reinf. inactive responses	6.0	7.4	10.4	-3.2	-2.7	2.1
Condit. Reinf. lever presses	3.1	4.3	8.1	-2.8	-1.8	1.3
Condit. Reinf. lever reinforcers received	5.8	8.2	10.6	-3.3	-2.9	2.4
Conditioned reinforcement - actives	0.4	0.4	0.6	-0.7	-0.8	0.4
Conditioned reinforcement - inactives	3.7	4.1	4.7	-2.1	-1.8	2.2
Conditioned locomotion	2.9	3.5	4.0	-1.9	-2.0	1.7
Patch foraging indifference point 0 sec	7.5	12.1	14.7	-3.8	-3.6	2.9
Patch foraging indifference point AUC	2.7	3.1	3.2	-1.8	-1.8	1.8
Delay disc. indifference point, 0s delay	0.9	0.9	1.5	1.2	0.8	-0.8
Delay disc. indifference point, 16s delay	0.2	0.2	0.6	-0.3	-0.8	-0.1
Delay disc. indifference point, 2s delay	0.3	0.3	0.5	0.0	-0.7	0.7
Delay disc. indifference point, 24s delay	3.2	3.1	4.4	-1.9	-2.1	1.2
Delay disc. indifference point, 4s delay	1.1	1.1	1.2	1.1	1.1	-1.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.4	0.0	-0.5
Indifference point function ln k	0.4	0.5	1.1	0.0	0.6	-1.1
Indifference point function log k	0.4	0.5	1.1	0.0	0.6	-1.1
Patch foraging total patch changes 0 sec	7.3	11.8	13.8	-3.7	-3.6	2.9
Patch foraging total patch changes 12 sec	7.1	9.1	10.4	-2.7	-3.2	3.1
Patch foraging total patch changes 18 sec	4.9	6.3	7.8	-2.8	-2.5	2.2
Patch foraging total patch changes 24 sec	7.6	9.3	11.5	-3.4	-3.2	2.6
Patch foraging total patch changes 6 sec	5.4	8.1	9.5	-3.1	-2.7	2.7
Patch foraging time to switch 0 sec	0.8	1.3	1.9	1.4	1.2	-0.8
Patch foraging water rate 0 sec	3.6	5.8	7.2	-2.7	-2.5	2.1
Patch foraging water rate 12 sec	0.2	0.3	0.5	-0.4	0.6	-0.7
Patch foraging water rate 18 sec	0.2	0.2	0.7	-0.8	0.0	-0.1
Patch foraging water rate 24 sec	0.1	0.1	0.1	0.0	0.4	-0.4
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.5	-0.1	-0.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.5	-0.7	-0.7	0.1
Distance traveled before self-admin	1.6	1.7	2.0	1.3	1.4	-1.2
Distance traveled after self-admin	0.5	0.6	0.9	0.4	0.9	-0.8
Extensor digitorum longus weight	0.9	3.7	7.6	2.8	0.9	-1.6
Bone: elastic displacement	1.0	1.2	1.8	0.2	1.3	-1.3
Bone: elastic work	0.7	0.8	2.0	-1.4	-0.4	0.7
Bone: endosteal estimation	10.8	23.6	33.0	-4.0	-4.6	5.7
Bone: endosteal perimeter	13.0	26.9	36.2	-4.4	-5.0	6.0
Epididymis fat weight	1.5	3.4	4.9	-1.3	-2.2	2.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.2	0.5	0.2
Delta time in open arm before/after self-admin	0.5	0.5	0.8	0.7	0.1	-0.9
Diff in mean of infusions in LGA sessions	0.5	0.5	1.1	0.2	0.7	-1.0
Delay discount exponential model param	0.1	0.1	0.3	0.0	0.5	-0.2
Extinction: sum of active levers before priming	0.3	0.3	0.5	-0.4	-0.7	0.3
Active lever presses in extinction session 6	1.7	1.6	1.8	-1.3	-1.3	1.2
Bone: final force	2.4	3.9	6.1	-2.5	-1.4	1.9
Bone: final moment	2.5	4.0	6.3	-2.5	-1.4	1.9
Food consumed during 24 hour testing period	3.8	4.6	5.5	-2.1	-2.3	2.0
Glucose	1.0	1.5	1.7	1.1	1.3	-1.3
Heart weight	0.1	0.1	0.3	-0.3	-0.1	-0.6
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.1	0.5	-0.1
Intermittent access intake day 1-15 change	0.3	0.3	0.6	0.8	0.2	0.2
Intermittent access intake escalation	0.4	0.4	0.8	0.9	0.5	-0.1
Intermittent access intake escalation 2	0.3	0.3	0.7	0.4	-0.2	0.9
Intermitt. access day 1 inactive lever presses	6.0	6.4	8.9	-3.0	-2.3	2.3
Intermitt. access day 15 inactive lever presses	2.0	2.2	2.6	-1.4	-1.6	1.4
Intermitt. access escalation Index	5.3	4.7	5.4	2.2	2.3	-2.0
Intermittent access day 1 total infusions	1.8	2.0	3.2	-1.8	-1.4	0.9
Intermittent access day 15 total infusions	0.4	0.4	0.6	-0.6	-0.8	0.6
Intermittent access terminal intake (last 3 days)	2.4	2.7	3.3	-1.3	-1.7	1.8
Intermittent access total infusions	4.0	4.5	5.2	-2.3	-2.1	1.9
Intermittent access day 1 locomotion	5.3	5.6	7.3	-2.7	-2.4	2.0
Intermittent access day 15 total locomotion	6.4	6.9	7.4	-2.7	-2.6	2.6
Intermittent access total locomotion	12.1	13.8	16.6	-4.1	-3.7	3.4
Intermittent access standard deviation	2.0	2.1	2.5	-1.6	-1.5	1.3
Left kidney weight	0.4	1.1	2.2	-1.5	0.2	-1.1
Right kidney weight	0.3	0.7	1.7	-1.3	0.2	-0.7
Cocaine induced anxiety	0.1	0.2	0.3	0.1	0.4	-0.6
Post-drug Anxiety	0.8	0.8	1.0	1.0	0.8	-1.0
Baseline Anxiety	1.0	1.1	1.2	1.1	0.9	-1.1
Tail length	2.3	6.8	7.5	-2.5	-2.7	2.6
Length with tail	1.8	6.6	9.3	-2.2	-2.3	3.0
Length without tail	0.2	0.4	1.1	0.2	-0.0	1.0
Times rat made contact with spout	0.6	0.7	0.9	-0.8	-0.8	0.9
Lifetime Intake	5.7	6.5	8.7	-2.9	-2.5	2.1
Liver weight, left	0.5	0.8	1.4	-0.6	-0.7	1.2
Liver weight, right	0.0	0.0	0.1	-0.3	-0.0	0.2
Locomotor activity	2.6	4.2	10.3	-3.2	-1.3	0.7
Locomotor testing distance	3.2	5.4	11.9	-3.5	-1.9	0.7
Locomotor testing rearing	1.5	2.3	5.1	-2.3	-1.1	0.7
Locomotion in novel chamber	0.1	0.2	0.4	0.3	0.6	-0.1
Locomotion in novel chamber post-restriction	1.4	1.7	3.3	-0.6	-1.3	1.8
Fecal boli incidents, locomotor time 1	0.6	0.6	1.4	1.2	0.4	-0.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.2	-0.4	0.2
Time >=10cm from walls, locomotor time 1	1.9	2.0	3.3	1.1	1.8	-1.2
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.4	0.2	-0.3
Total resting periods, locomotor time 1	0.2	0.2	0.5	0.7	0.3	-0.3
Rest time, locomotor task time 1	1.1	1.2	2.5	1.6	0.8	-0.7
Distance moved, locomotor task time 1	1.2	1.3	1.7	-1.3	-1.1	1.0
Vertical activity count, locomotor time 1	0.6	0.6	0.9	-1.0	-0.6	0.7
Time >=10cm from walls, locomotor time 2	0.6	0.7	1.4	0.8	1.2	-0.3
Bouts of movement, locomotor time 2	0.1	0.1	0.2	0.3	0.0	-0.4
Total resting periods, locomotor time 2	0.3	0.3	0.5	0.5	0.3	-0.7
Rest time, locomotor task time 2	6.3	7.2	10.7	3.3	2.3	-2.4
Distance moved, locomotor task time 2	1.0	1.2	1.9	-1.4	-0.7	1.1
Vertical activity count, locomotor time 2	3.9	4.2	6.2	-2.5	-1.8	1.8
Light reinforcement 1	1.0	1.8	2.9	-1.7	-1.6	0.2
Light reinforcement 2	0.9	1.2	2.1	-1.1	-1.5	0.6
Bone: marrow area	10.4	22.4	31.8	-3.9	-4.5	5.6
Bone: maximum diameter	5.6	10.3	11.5	-3.3	-3.0	3.4
Bone: maximum force	4.7	8.1	11.4	-3.4	-2.5	2.5
Bone: maximum moment	4.7	8.1	11.2	-3.4	-2.5	2.6
Mean time between licks in bursts	0.2	0.2	0.3	-0.1	-0.6	0.5
Mean num. licks in bursts	0.5	0.6	1.0	-0.7	-1.0	0.6
Cd content in liver	4.9	5.4	7.6	2.8	2.1	-2.0
Co content in liver	1.0	1.2	1.8	1.4	1.2	-0.7
Cu content in liver	0.1	0.1	0.1	0.3	-0.4	0.2
Fe content in liver	0.1	0.1	0.2	-0.3	0.2	-0.5
K content in liver	0.4	0.4	1.0	-0.2	-0.4	1.0
Mg content in liver	0.4	0.4	0.9	0.9	0.2	0.5
Mn content in liver	0.0	0.1	0.1	-0.3	0.0	0.2
Na content in liver	0.1	0.1	0.3	-0.5	-0.2	0.2
Rb content in liver	2.0	2.5	3.5	1.5	1.9	-1.3
Se content in liver	1.1	1.3	1.7	1.1	1.0	-1.3
Sr content in liver	0.7	0.6	1.0	-1.0	-0.6	0.7
Zn content in liver	0.0	0.0	0.0	-0.0	-0.0	0.2
Bone: minimum diameter	13.5	25.3	28.8	-4.8	-4.9	5.4
Time in familiar zone, hab. session 1	0.5	0.5	0.8	0.1	-0.7	0.9
Time in novel zone, hab. session 1	0.5	0.5	0.8	-0.1	0.8	-0.9
Total zone transitions, hab. session 1	1.2	1.7	3.6	-1.9	-1.0	0.7
Total locomotion distance, hab. session 1	3.1	4.4	8.2	-2.9	-1.6	1.5
Locomotion velocity, hab. session 1	2.9	4.1	7.0	-2.7	-1.7	1.5
Time in familiar zone, hab. session 2	1.0	1.1	1.5	-0.9	-1.0	1.2
Time in novel zone, hab. session 2	0.6	0.6	0.7	0.7	0.8	-0.7
Total zone transitions, hab. session 2	0.6	0.8	1.7	-1.3	-0.6	0.5
Total locomotion distance, hab. session 2	1.9	2.6	3.6	-1.9	-1.6	1.3
Locomotion velocity, hab. session 2	1.7	2.3	3.0	-1.7	-1.5	1.2
Novel to familiar place preference ratio	0.9	1.0	1.3	-1.0	-0.8	1.1
Novelty place preference	0.5	0.5	0.7	-0.8	-0.6	0.8
Time in novel zone, NPP test	0.4	0.5	0.7	-0.8	-0.4	0.7
Total zone transitions, NPP test	1.1	1.5	3.6	-1.9	-0.9	0.3
Total locomotion distance, NPP test	2.1	2.8	4.6	-2.1	-1.5	1.3
Locomotion velocity, NPP test	1.9	2.7	4.2	-2.1	-1.7	1.1
Intraocular pressure	1.0	1.4	2.6	-1.3	-1.6	0.2
Delta distance traveled before/after self-admin	0.2	0.2	0.7	-0.8	0.0	-0.2
Delta ambulatory time before/after self-admin	0.3	0.3	0.6	-0.8	-0.4	0.3
Parametrial fat weight	0.5	1.0	2.3	0.1	-0.9	1.5
Pavlov. Cond. lever latency	2.0	2.5	5.3	2.3	1.2	-0.9
Pavlov. Cond. magazine entry latency	2.8	3.7	5.4	-2.3	-1.7	1.6
Pavlov. Cond. change in total contacts	2.7	2.9	5.1	-2.3	-1.4	1.2
Pavlov. Cond. index score	3.0	3.8	6.4	-2.5	-1.7	1.5
Pavlov. Cond. latency score	2.7	3.4	6.3	-2.5	-1.5	1.3
Pavlov. Cond. lever contacts	1.2	1.4	3.0	-1.7	-0.8	0.7
Pavlov. Cond. magazine entry number	1.9	2.3	3.6	1.9	1.4	-1.2
Pavlov. Cond. intertrial magazine entries	2.6	3.1	4.5	-1.9	-2.1	1.2
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.4	5.9	-2.4	-1.5	1.3
Pavlov. Cond. response bias	2.2	2.7	4.8	-2.2	-1.4	1.2
Pavlov. Cond. lever latency	0.4	0.5	1.3	1.1	0.5	-0.3
Pavlov. Cond. magazine entry latency	3.0	3.4	4.4	1.7	2.1	-1.7
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	-0.7	-0.4	0.3
Pavlov. Cond. index score	0.1	0.1	0.2	-0.2	0.4	-0.4
Pavlov. Cond. latency score	0.2	0.3	0.4	-0.1	0.7	-0.6
Pavlov. Cond. lever contacts	0.5	0.7	1.5	-1.2	-0.7	0.3
Pavlov. Cond. magazine entry number	3.6	4.4	5.7	-1.7	-2.4	2.1
Pavlov. Cond. intertrial magazine entries	13.7	17.8	21.4	-3.3	-4.6	4.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	-0.0	0.6	-0.5
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.6	-0.1	-0.0
Time in closed arm before self-admin	0.5	0.5	0.6	-0.6	0.8	-0.8
Time in closed arm after self-admin	0.7	0.7	1.9	0.4	1.4	-0.3
Time in open arm before self-admin	1.3	1.4	1.8	1.3	1.2	-0.9
Time in open arm after self-admin	0.2	0.3	0.6	0.8	-0.4	-0.3
Bone: periosteal estimation	10.8	22.4	25.0	-4.8	-4.4	5.0
Bone: periosteal perimeter	5.4	9.1	10.4	-3.2	-2.6	3.1
Bone: post-yield work	2.5	3.4	4.8	-1.7	-1.6	2.2
Progressive ratio test 1 active lever presses	6.7	7.0	9.5	-3.1	-2.6	2.2
Progressive ratio test 1 breakpoint	8.5	8.9	11.7	-3.4	-3.0	2.4
Progressive ratio test 1 inactive lever presses	8.8	9.6	13.6	-3.7	-2.9	2.5
Progressive ratio test 2 active lever presses	5.1	5.4	6.3	-2.2	-2.5	2.2
Progressive ratio test 2 breakpoint	5.1	5.7	6.5	-2.2	-2.5	2.4
Progressive ratio test 2 inactive lever presses	6.7	7.7	8.6	-2.8	-2.9	2.6
Incentive Sensitization - Responses	2.0	2.1	2.9	-0.9	-1.6	1.7
Incentive Sensitization - Breakpoint	1.8	1.8	2.8	-0.8	-1.4	1.7
Sum of active levers in priming session hrs 5-6	0.9	0.9	1.8	0.7	0.6	-1.3
Progressive ratio	0.6	0.7	1.7	1.3	0.6	-0.0
Food seeking constrained by brief footshock	2.2	2.7	4.7	-1.1	-1.5	2.2
Seeking ratio, punishment vs. effort	1.8	2.2	3.2	-1.8	-1.4	1.3
Retroperitoneal fat weight	2.4	8.0	9.8	-2.6	-2.7	3.1
Reaction time number correct	0.7	1.0	1.5	0.8	0.9	-1.2
Reaction time mean minus median	0.7	0.9	1.8	1.4	0.7	-0.6
Reaction time mean minus median AUC	0.9	1.2	1.5	1.2	1.1	-1.0
Reaction time num false alarms	3.7	5.0	7.7	-2.8	-2.1	1.8
Reaction time num false alarms AUC	3.7	5.2	7.0	-2.6	-2.2	2.0
Reaction time trials correct on left	0.7	1.0	1.5	0.8	0.9	-1.2
Reaction time trials on left	0.6	0.9	1.4	0.8	0.8	-1.2
Reaction time mean	1.1	1.6	2.0	1.4	1.3	-1.0
Reaction time mean AUC	1.7	2.2	2.6	1.6	1.6	-1.3
Median of all reaction times	0.9	1.2	1.5	1.1	1.2	-0.9
Reaction time omissions	0.1	0.2	0.3	0.5	-0.1	0.5
Reaction time false alarm rate	3.5	4.9	6.2	-2.5	-2.0	2.1
Reaction time premature initiation rate	1.6	2.2	3.2	-1.8	-1.6	0.9
Reaction time premature initiations	0.6	0.9	1.3	-1.2	-1.1	0.3
Std. dev. reaction times	1.0	1.4	3.0	1.7	1.0	-0.5
Reaction time trials completed	0.6	0.9	1.4	0.8	0.8	-1.2
Reaction time trials AUC	0.7	0.9	1.4	0.9	0.9	-1.2
Run reversals in cocaine runway, females	0.5	0.5	1.0	1.0	0.5	-0.5
Run reversals in cocaine runway, males	0.2	0.2	0.3	0.5	0.4	-0.4
Latency to leave start box in cocaine runway	0.3	0.4	0.5	0.3	0.7	-0.7
Latency to leave start box in cocaine runway, F	0.7	0.7	1.3	-0.1	0.9	-1.1
Latency to leave start box in cocaine runway, M	0.3	0.3	0.8	0.9	0.4	0.1
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.0	-0.3	0.1
Total sessions with >9 infusions	1.7	1.9	4.1	-2.0	-1.2	0.2
Short access day 1 total inactive lever presses	2.4	2.7	4.5	-2.1	-1.3	1.4
Short access day 10 total inactive lever presses	1.2	1.3	1.5	-1.0	-1.2	1.2
Short access day 1 total infusions	4.0	4.2	8.4	-2.9	-1.9	0.9
Short access day 10 total infusions	10.9	12.1	14.8	-3.9	-3.4	3.1
Short access total infusions	6.9	7.8	12.9	-3.6	-2.6	2.0
Short access day 1 locomotion	7.9	8.5	12.2	-3.5	-3.1	2.0
Short access day 10 total locomotion	13.8	15.4	16.8	-4.1	-4.0	3.6
Short access total locomotion	10.9	11.3	16.7	-4.1	-3.3	2.5
One hour access (0.3 mA shock)	1.1	1.3	1.4	-1.2	-1.0	1.2
Compulsive drug intake	1.5	1.5	2.3	1.1	1.5	-1.0
One hour access (shock baseline)	2.1	2.4	2.8	-1.5	-1.7	1.4
Social response proportion	0.2	0.2	0.3	0.4	0.5	-0.6
Social responses	0.4	0.5	1.4	-1.2	-0.4	0.2
Social time	0.6	0.8	1.6	1.2	0.7	-0.6
Soleus weight	0.2	0.7	1.7	-1.3	-0.7	-0.0
Bone: stiffness	2.2	3.5	4.8	-2.2	-1.6	1.7
Tibialis anterior weight	0.3	1.0	2.0	-0.7	-1.4	0.8
Time to tail flick, vehicle, before self-admin	1.5	1.5	2.8	1.7	1.2	-0.5
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.5	0.3	-0.7	0.6
Time to tail flick, test, before self-admin	2.3	2.2	4.1	2.0	1.4	-0.8
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.4	0.3	-0.6
Delta time to tail flick, vehicle, before/after SA	2.4	2.4	3.2	-1.1	-1.8	1.7
Delta time to tail flick, test, before/after SA	0.1	0.0	0.1	-0.3	-0.2	-0.1
Tibia length	0.2	0.7	2.0	-1.4	-0.3	-0.2
Ambulatory time before self-admin	0.8	0.8	1.1	0.8	1.1	-0.8
Ambulatory time after self-admin	0.1	0.1	0.1	-0.3	0.2	-0.2
Bone: tissue strength	0.6	0.6	1.0	0.3	0.8	-1.0
Total heroin consumption	0.1	0.1	0.4	-0.6	-0.1	-0.1
Bone: trabecular number	1.6	2.5	3.1	-1.6	-1.5	1.7
Bone: trabecular spacing	0.6	0.8	0.9	1.0	0.8	-0.9
Bone: trabecular thickness	2.1	2.5	3.1	-1.4	-1.6	1.8
Bone: trabecular tissue density	0.1	0.2	0.5	-0.2	0.1	-0.7
Water consumed over 24 hours	0.7	0.8	1.4	-1.2	-0.7	0.7
Number of responses in last shaping day	1.0	1.0	2.1	-1.4	-1.0	0.4