Hub : Genes

Poldip2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Poldip2 0.04 0.04 1.9e-03 0.02 0.02 0.02 0.02 2.2e-03 2.4e-03 4.9e-03 3.0e-03
2 Brain mRNA stability Poldip2 0.14 0.11 3.1e-09 0.08 0.1 0.09 0.09 5.5e-08 2.9e-09 1.1e-08 6.0e-09
3 Liver mRNA stability Poldip2 0.07 0.06 1.1e-08 0.06 0.06 0.06 0.06 5.8e-07 3.0e-07 7.4e-07 5.4e-07
4 Eye intron excision ratio chr10_63910586_63910795 0.33 0.24 1.8e-03 0.13 0.14 0.16 0.13 4.5e-03 3.2e-03 1.9e-03 4.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density1.93.53.81.9-1.9-2.01.8
Area under the delay curve0.71.11.7-0.90.91.3-1.1
BMI with tail1.96.86.92.6-2.6-2.62.6
BMI without tail1.15.76.42.4-2.4-2.52.3
Body weight2.812.312.83.6-3.6-3.53.4
Weight adjusted by age0.00.00.10.1-0.1-0.30.0
Bone surface1.52.93.21.6-1.7-1.71.8
Bone volume1.32.62.61.6-1.6-1.61.6
Breakpoint value in progressive ratio session0.10.30.40.4-0.4-0.70.6
Number of licking bursts0.10.40.5-0.70.70.7-0.5
Context. condit. distance diff. score0.50.60.70.9-0.8-0.80.7
Locomotion velocity, session 12.22.52.61.6-1.6-1.61.6
Locomotion distance, session 10.20.30.30.6-0.6-0.60.5
Locomotion velocity, session 20.00.00.10.1-0.1-0.20.3
Locomotion distance, session 21.31.82.51.2-1.3-1.31.6
Locomotion velocity, session 33.33.84.3-2.12.02.0-1.6
Locomotion distance, session 30.30.40.4-0.60.60.7-0.5
Stereotopy head waving bouts, day 30.00.00.0-0.10.0-0.10.1
Stereotopy head waving duration, day 30.70.91.1-1.11.10.8-0.9
Locomotion velocity, session 70.10.10.20.3-0.3-0.50.3
Locomotion distance, session 70.30.30.50.6-0.6-0.70.4
Stereotopy head waving bouts, day 70.50.50.60.7-0.7-0.80.8
Stereotopy head waving duration, day 70.10.10.20.3-0.3-0.50.4
Locomotion velocity, session 80.10.10.10.2-0.3-0.20.4
Locomotion distance, session 80.81.21.21.1-1.1-1.11.1
Degree of sensitization distance2.62.83.21.7-1.7-1.81.5
Degree of sensitization stereotypy0.50.50.60.7-0.7-0.80.7
Conditioned locomotion1.72.02.5-1.61.51.4-1.2
Cocaine response after cond. corrected1.42.02.31.4-1.4-1.41.5
Cocaine response after cond. not corrected1.92.73.01.6-1.6-1.61.7
Cocaine response before conditioning0.20.20.20.5-0.4-0.50.4
Saline control response0.00.00.0-0.10.20.1-0.1
Bone: connectivity density3.55.66.12.3-2.3-2.52.4
Bone: cortical apparent density0.50.80.9-0.90.90.9-0.9
Bone: cortical area1.11.72.1-1.41.31.5-1.1
Bone: cortical porosity0.20.20.30.5-0.4-0.50.2
Bone: cortical porosity0.10.10.10.3-0.2-0.30.1
Bone: cortical thickness2.74.54.9-2.12.22.2-2.0
Bone: cortical thickness0.10.10.1-0.30.30.2-0.3
Bone: cortical tissue density0.30.50.5-0.70.70.6-0.7
Condit. Reinf. active minus inactive responses0.80.91.0-1.01.00.9-0.9
Condit. Reinf. active-inactive response ratio0.20.20.3-0.40.40.4-0.5
Condit. Reinf. active responses0.00.00.0-0.20.20.10.0
Condit. Reinf. inactive responses0.30.40.80.5-0.6-0.60.9
Incentive salience index mean0.20.30.4-0.60.60.6-0.4
Condit. Reinf. lever presses0.10.20.30.3-0.4-0.40.5
Condit. Reinf. active minus inactive responses0.60.91.1-1.01.00.8-0.9
Condit. Reinf. active-inactive response ratio0.60.91.0-1.01.00.9-0.9
Condit. Reinf. active responses0.40.60.8-0.90.90.6-0.8
Condit. Reinf. inactive responses0.00.00.0-0.00.0-0.1-0.1
Condit. Reinf. lever presses2.53.63.8-1.91.91.9-1.8
Condit. Reinf. lever reinforcers received0.71.01.1-1.11.10.9-1.0
Conditioned reinforcement - actives0.10.50.50.7-0.7-0.70.7
Conditioned reinforcement - inactives0.10.40.50.7-0.6-0.50.6
Conditioned locomotion0.60.91.01.0-0.9-0.71.0
Patch foraging indifference point 0 sec0.30.90.9-1.01.00.9-1.0
Patch foraging indifference point AUC1.33.03.4-1.81.81.8-1.5
Delay disc. indifference point, 0s delay0.50.60.8-0.50.70.9-0.8
Delay disc. indifference point, 16s delay0.30.51.0-0.50.51.0-0.7
Delay disc. indifference point, 2s delay2.42.72.8-1.61.61.7-1.7
Delay disc. indifference point, 24s delay0.50.80.90.9-0.9-0.90.9
Delay disc. indifference point, 4s delay0.10.10.2-0.10.20.4-0.4
Delay disc. indifference point, 8s delay0.30.50.8-0.70.60.9-0.6
Indifference point function ln k0.20.70.80.9-0.8-0.90.7
Indifference point function log k0.20.70.80.9-0.8-0.90.7
Patch foraging total patch changes 0 sec0.30.70.8-0.90.90.8-0.9
Patch foraging total patch changes 12 sec0.10.20.2-0.40.40.5-0.3
Patch foraging total patch changes 18 sec1.12.62.8-1.71.71.6-1.5
Patch foraging total patch changes 24 sec1.03.53.9-2.01.91.8-1.8
Patch foraging total patch changes 6 sec2.84.75.1-2.22.12.3-2.1
Patch foraging time to switch 0 sec0.82.93.11.7-1.8-1.71.6
Patch foraging water rate 0 sec0.93.43.5-1.81.91.8-1.8
Patch foraging water rate 12 sec0.00.10.20.4-0.3-0.50.1
Patch foraging water rate 18 sec0.30.60.80.9-0.8-0.80.6
Patch foraging water rate 24 sec0.10.10.2-0.40.30.5-0.4
Patch foraging water rate 6 sec1.21.71.9-1.31.41.3-1.4
Seeking ratio, delayed vs. immediate footshock1.31.92.2-1.31.31.5-1.3
Distance traveled before self-admin2.24.84.9-2.12.22.2-2.2
Distance traveled after self-admin0.00.10.1-0.20.30.3-0.4
Extensor digitorum longus weight0.83.23.41.8-1.8-1.81.7
Bone: elastic displacement2.63.33.5-1.91.81.9-1.7
Bone: elastic work8.310.811.4-3.43.33.4-3.1
Bone: endosteal estimation0.00.00.00.1-0.2-0.10.2
Bone: endosteal perimeter0.10.10.20.3-0.4-0.20.5
Epididymis fat weight5.628.530.25.5-5.4-5.45.0
Delta time in closed arm before/after self-admin3.53.33.7-1.81.81.7-1.9
Delta time in open arm before/after self-admin6.37.58.22.8-2.7-2.62.9
Diff in mean of infusions in LGA sessions0.40.80.80.9-0.8-0.90.9
Delay discount exponential model param0.50.71.10.7-0.7-1.10.9
Extinction: sum of active levers before priming0.60.91.01.0-0.9-1.01.0
Active lever presses in extinction session 60.00.00.10.1-0.0-0.4-0.0
Bone: final force0.20.30.4-0.60.50.7-0.4
Bone: final moment0.20.30.5-0.60.60.7-0.4
Food consumed during 24 hour testing period0.30.61.1-0.70.80.6-1.0
Glucose1.42.22.3-1.51.51.5-1.4
Heart weight1.32.02.41.4-1.4-1.51.4
Delay discount hyperbolic model param0.91.21.61.0-1.0-1.31.1
Intermittent access intake day 1-15 change0.00.00.10.2-0.0-0.2-0.2
Intermittent access intake escalation0.00.10.20.4-0.2-0.40.0
Intermittent access intake escalation 20.10.20.3-0.40.40.4-0.6
Intermitt. access day 1 inactive lever presses0.00.10.1-0.30.30.4-0.3
Intermitt. access day 15 inactive lever presses0.10.60.7-0.70.90.8-0.8
Intermitt. access escalation Index0.41.31.61.2-1.3-1.10.8
Intermittent access day 1 total infusions0.20.61.10.6-0.8-0.51.0
Intermittent access day 15 total infusions0.71.71.81.3-1.3-1.21.4
Intermittent access terminal intake (last 3 days)1.11.92.01.4-1.4-1.31.4
Intermittent access total infusions0.60.81.10.9-0.9-0.71.0
Intermittent access day 1 locomotion0.10.20.50.3-0.4-0.20.7
Intermittent access day 15 total locomotion0.20.71.00.8-0.8-0.81.0
Intermittent access total locomotion0.81.01.40.9-1.0-0.91.2
Intermittent access standard deviation0.00.00.10.2-0.2-0.10.2
Left kidney weight0.00.30.30.5-0.6-0.50.4
Right kidney weight0.10.80.90.9-0.9-0.90.9
Cocaine induced anxiety0.10.10.2-0.40.40.4-0.4
Post-drug Anxiety0.10.10.10.3-0.2-0.40.1
Baseline Anxiety0.10.10.20.3-0.2-0.50.1
Tail length0.31.41.71.3-1.2-1.30.9
Length with tail0.62.52.81.7-1.7-1.61.3
Length without tail0.31.51.81.3-1.3-1.21.1
Times rat made contact with spout0.10.20.2-0.40.40.3-0.5
Lifetime Intake1.01.31.71.1-1.1-0.91.3
Liver weight, left4.78.28.72.9-2.9-2.92.8
Liver weight, right4.06.97.12.6-2.6-2.72.6
Locomotor activity0.00.10.2-0.10.20.2-0.4
Locomotor testing distance0.00.10.2-0.30.30.3-0.5
Locomotor testing rearing0.10.20.4-0.40.50.3-0.6
Locomotion in novel chamber2.02.73.1-1.61.61.8-1.7
Locomotion in novel chamber post-restriction0.00.00.00.0-0.0-0.0-0.0
Fecal boli incidents, locomotor time 10.71.82.01.2-1.3-1.41.4
Change in fecal boli incidents, locomotor task0.00.00.10.0-0.00.3-0.1
Time >=10cm from walls, locomotor time 10.00.00.00.1-0.1-0.20.1
Bouts of movement, locomotor time 10.40.50.5-0.60.60.7-0.7
Total resting periods, locomotor time 10.10.10.1-0.40.40.4-0.4
Rest time, locomotor task time 10.00.10.10.2-0.2-0.40.3
Distance moved, locomotor task time 10.10.20.3-0.40.40.6-0.5
Vertical activity count, locomotor time 10.00.00.10.0-0.10.20.0
Time >=10cm from walls, locomotor time 20.51.51.61.2-1.2-1.11.3
Bouts of movement, locomotor time 20.10.50.5-0.70.70.7-0.7
Total resting periods, locomotor time 20.00.20.2-0.40.50.4-0.5
Rest time, locomotor task time 20.20.30.4-0.60.60.2-0.5
Distance moved, locomotor task time 20.00.00.2-0.00.00.4-0.1
Vertical activity count, locomotor time 20.00.10.20.2-0.20.40.1
Light reinforcement 10.00.00.00.0-0.00.1-0.0
Light reinforcement 20.20.40.5-0.70.70.7-0.6
Bone: marrow area0.00.00.00.1-0.1-0.00.1
Bone: maximum diameter0.20.30.5-0.60.50.7-0.4
Bone: maximum force0.30.60.8-0.80.80.9-0.7
Bone: maximum moment0.40.71.0-0.80.81.0-0.8
Mean time between licks in bursts0.21.11.31.0-1.0-1.01.1
Mean num. licks in bursts0.10.30.40.6-0.6-0.60.3
Cd content in liver0.50.60.7-0.80.70.9-0.6
Co content in liver0.30.40.4-0.60.70.6-0.7
Cu content in liver1.92.32.5-1.61.61.4-1.5
Fe content in liver2.43.03.81.6-1.7-1.72.0
K content in liver0.20.20.20.5-0.4-0.30.4
Mg content in liver0.60.60.9-0.90.90.8-0.5
Mn content in liver0.30.30.4-0.60.60.5-0.5
Na content in liver0.30.40.50.7-0.6-0.30.7
Rb content in liver0.10.10.20.4-0.3-0.30.2
Se content in liver0.60.71.1-1.00.90.8-0.5
Sr content in liver0.30.30.40.7-0.5-0.60.1
Zn content in liver0.50.50.70.6-0.7-0.70.8
Bone: minimum diameter0.00.10.1-0.30.20.30.0
Time in familiar zone, hab. session 10.30.30.4-0.40.50.6-0.6
Time in novel zone, hab. session 10.10.10.10.3-0.3-0.40.3
Total zone transitions, hab. session 10.00.00.0-0.00.00.10.0
Total locomotion distance, hab. session 10.10.10.2-0.30.40.4-0.5
Locomotion velocity, hab. session 10.30.40.4-0.60.60.7-0.6
Time in familiar zone, hab. session 20.20.30.3-0.50.60.4-0.5
Time in novel zone, hab. session 20.00.00.1-0.20.10.3-0.1
Total zone transitions, hab. session 20.30.40.60.6-0.6-0.60.8
Total locomotion distance, hab. session 20.10.10.2-0.40.40.3-0.2
Locomotion velocity, hab. session 20.10.10.2-0.40.40.3-0.2
Novel to familiar place preference ratio0.70.91.01.0-1.0-1.00.9
Novelty place preference1.01.21.31.1-1.1-1.11.0
Time in novel zone, NPP test1.01.31.41.2-1.2-1.21.0
Total zone transitions, NPP test0.00.00.10.1-0.2-0.10.3
Total locomotion distance, NPP test0.81.21.4-1.21.11.1-0.9
Locomotion velocity, NPP test1.01.41.6-1.31.21.2-1.0
Intraocular pressure1.01.71.8-1.31.41.3-1.2
Delta distance traveled before/after self-admin3.03.33.51.9-1.8-1.81.8
Delta ambulatory time before/after self-admin1.72.93.11.8-1.7-1.71.7
Parametrial fat weight5.813.714.83.8-3.7-3.83.5
Pavlov. Cond. lever latency0.00.00.00.1-0.0-0.1-0.0
Pavlov. Cond. magazine entry latency0.00.10.10.2-0.2-0.20.3
Pavlov. Cond. change in total contacts0.30.30.4-0.60.60.6-0.3
Pavlov. Cond. index score0.00.00.0-0.10.00.10.1
Pavlov. Cond. latency score0.00.00.10.0-0.1-0.00.2
Pavlov. Cond. lever contacts0.00.00.00.1-0.10.00.2
Pavlov. Cond. magazine entry number0.10.10.10.4-0.3-0.40.2
Pavlov. Cond. intertrial magazine entries0.20.30.4-0.60.60.5-0.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.20.10.20.0
Pavlov. Cond. response bias0.00.00.00.0-0.10.00.2
Pavlov. Cond. lever latency2.63.63.71.9-1.9-1.91.9
Pavlov. Cond. magazine entry latency0.20.20.2-0.50.50.5-0.5
Pavlov. Cond. change in total contacts0.92.12.2-1.51.51.5-1.4
Pavlov. Cond. index score2.03.13.2-1.81.81.8-1.7
Pavlov. Cond. latency score2.33.73.8-1.91.91.9-1.9
Pavlov. Cond. lever contacts1.42.12.2-1.51.51.4-1.4
Pavlov. Cond. magazine entry number0.00.00.00.1-0.1-0.10.1
Pavlov. Cond. intertrial magazine entries0.30.60.60.7-0.8-0.80.8
Pavlov. Cond. lever-magazine prob. diff.1.52.42.4-1.61.61.5-1.5
Pavlov. Cond. response bias1.21.61.7-1.31.31.3-1.2
Time in closed arm before self-admin1.52.52.91.6-1.6-1.41.7
Time in closed arm after self-admin0.40.40.7-0.60.50.8-0.7
Time in open arm before self-admin2.63.23.9-1.81.81.5-2.0
Time in open arm after self-admin0.91.01.11.0-1.0-1.01.0
Bone: periosteal estimation0.20.50.7-0.70.60.8-0.5
Bone: periosteal perimeter0.10.20.3-0.40.30.6-0.2
Bone: post-yield work0.30.50.70.7-0.8-0.60.8
Progressive ratio test 1 active lever presses0.20.30.4-0.50.50.7-0.5
Progressive ratio test 1 breakpoint0.20.40.5-0.60.60.7-0.5
Progressive ratio test 1 inactive lever presses0.51.31.8-1.01.11.4-1.0
Progressive ratio test 2 active lever presses0.20.30.4-0.50.60.6-0.4
Progressive ratio test 2 breakpoint0.20.30.3-0.50.60.6-0.4
Progressive ratio test 2 inactive lever presses0.00.10.1-0.10.30.3-0.3
Incentive Sensitization - Responses0.00.00.10.00.0-0.10.2
Incentive Sensitization - Breakpoint0.00.00.10.0-0.0-0.10.3
Sum of active levers in priming session hrs 5-61.41.31.51.2-1.1-1.21.2
Progressive ratio0.00.00.0-0.20.2-0.1-0.1
Food seeking constrained by brief footshock0.10.10.10.3-0.3-0.30.3
Seeking ratio, punishment vs. effort0.00.00.00.1-0.10.20.0
Retroperitoneal fat weight0.62.53.01.7-1.7-1.61.3
Reaction time number correct0.41.31.51.2-1.2-1.21.1
Reaction time mean minus median0.00.30.30.4-0.5-0.50.6
Reaction time mean minus median AUC0.42.52.71.5-1.6-1.51.7
Reaction time num false alarms4.98.48.6-2.92.92.9-2.9
Reaction time num false alarms AUC3.78.68.8-2.93.02.9-2.9
Reaction time trials correct on left0.41.31.51.2-1.2-1.21.1
Reaction time trials on left0.41.41.61.3-1.2-1.21.1
Reaction time mean0.40.91.10.9-0.9-1.01.0
Reaction time mean AUC0.30.80.90.8-0.9-0.91.0
Median of all reaction times0.40.70.80.7-0.8-0.80.9
Reaction time omissions1.11.92.01.4-1.4-1.41.3
Reaction time false alarm rate6.38.89.0-3.03.03.0-2.9
Reaction time premature initiation rate0.20.40.40.6-0.7-0.50.6
Reaction time premature initiations0.20.70.90.9-0.9-0.80.8
Std. dev. reaction times0.41.21.21.1-1.1-1.11.1
Reaction time trials completed0.41.41.61.3-1.2-1.21.1
Reaction time trials AUC0.31.11.31.1-1.0-1.00.9
Run reversals in cocaine runway, females0.00.00.10.2-0.2-0.30.1
Run reversals in cocaine runway, males0.10.10.20.4-0.4-0.30.3
Latency to leave start box in cocaine runway1.11.52.0-1.21.30.8-1.4
Latency to leave start box in cocaine runway, F0.30.40.6-0.70.70.3-0.8
Latency to leave start box in cocaine runway, M0.60.61.0-0.80.80.5-1.0
Std. dev. time between licks in bursts0.00.10.10.2-0.3-0.20.3
Total sessions with >9 infusions0.91.11.61.0-1.1-0.71.3
Short access day 1 total inactive lever presses2.95.86.32.5-2.5-2.22.5
Short access day 10 total inactive lever presses0.00.00.00.2-0.10.10.1
Short access day 1 total infusions0.91.82.21.4-1.4-1.01.5
Short access day 10 total infusions0.50.91.30.9-1.0-0.71.1
Short access total infusions0.50.71.10.8-0.9-0.51.1
Short access day 1 locomotion0.00.10.10.3-0.30.00.3
Short access day 10 total locomotion0.10.50.6-0.70.70.8-0.6
Short access total locomotion0.10.20.4-0.40.40.6-0.2
One hour access (0.3 mA shock)0.00.00.1-0.20.10.20.1
Compulsive drug intake0.81.21.31.0-1.1-1.11.1
One hour access (shock baseline)0.00.10.1-0.30.40.4-0.3
Social response proportion2.63.23.51.9-1.8-1.71.8
Social responses2.12.72.81.7-1.7-1.61.6
Social time1.62.52.91.6-1.7-1.51.6
Soleus weight2.47.17.52.6-2.7-2.62.7
Bone: stiffness1.83.33.61.9-1.9-1.81.7
Tibialis anterior weight2.79.49.83.0-3.1-3.13.0
Time to tail flick, vehicle, before self-admin0.20.20.30.5-0.5-0.30.5
Time to tail flick, vehicle, after self-admin0.10.30.4-0.50.50.7-0.4
Time to tail flick, test, before self-admin0.00.00.0-0.10.0-0.1-0.0
Time to tail flick, test, after self-admin1.21.31.6-1.21.20.8-1.3
Delta time to tail flick, vehicle, before/after SA0.60.60.8-0.90.90.7-0.7
Delta time to tail flick, test, before/after SA0.50.60.7-0.80.80.7-0.8
Tibia length0.00.00.0-0.20.10.2-0.2
Ambulatory time before self-admin0.61.72.1-1.21.21.5-1.3
Ambulatory time after self-admin0.00.00.00.2-0.1-0.10.0
Bone: tissue strength1.41.41.7-1.21.21.3-1.1
Total heroin consumption2.22.63.51.5-1.4-1.91.6
Bone: trabecular number2.44.55.02.1-2.1-2.22.1
Bone: trabecular spacing0.20.30.3-0.50.50.6-0.5
Bone: trabecular thickness0.00.00.0-0.0-0.00.00.0
Bone: trabecular tissue density1.11.81.9-1.41.41.4-1.3
Water consumed over 24 hours0.00.10.1-0.20.20.2-0.3
Number of responses in last shaping day0.60.81.3-0.80.91.1-0.8