Pold3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	alternative TSS	XM_039106085.1	0.06	0.05	8.8e-03	0.02	0.02	0	0.01	3.3e-02	4.2e-02	2.6e-01	1.3e-01
2	BLA	alternative TSS	XM_039106085.1	0.07	0.06	6.0e-03	0.02	0.01	-0	0	3.0e-02	6.0e-02	5.0e-01	1.7e-01
3	PL	intron excision ratio	chr1_154447869_154455018	0.05	0.04	3.1e-04	0.03	0.02	0.01	0.02	2.1e-04	3.1e-03	7.2e-03	3.4e-03
4	Liver	isoform ratio	XM_039106085.1	0.03	0.02	1.5e-03	0	0.01	0	0.01	1.5e-01	1.0e-02	8.9e-02	6.0e-02
5	Liver	isoform ratio	NM_001024750.1	0.03	0.02	1.8e-03	0.01	0.02	0.01	0.02	1.3e-02	1.9e-03	1.2e-02	3.1e-03
6	Liver	gene expression	Pold3	0.34	0.12	0.0e+00	0.16	0.19	0.19	0.19	4.5e-17	1.0e-20	9.5e-21	1.8e-20
7	Liver	alternative TSS	XM_039106084.1	0.04	0.03	1.8e-04	0.03	0.02	0.02	0.02	5.2e-04	1.2e-03	1.3e-03	1.6e-03
8	Liver	alternative TSS	NM_001024750.1	0.04	0.03	9.3e-05	0.03	0.03	0.03	0.03	2.7e-04	7.7e-04	8.0e-04	7.6e-04
9	Liver	alternative TSS	XM_039106085.1	0.04	0.03	7.7e-05	0.03	0.03	0.02	0.03	1.5e-04	4.3e-04	2.5e-03	5.4e-04
10	Liver	alternative TSS	XM_039106085.1	0.04	0.03	4.6e-05	0.03	0.03	0.03	0.03	1.1e-04	3.6e-04	8.6e-04	3.3e-04
11	PL	intron excision ratio	chr1_154443944_154455018	0.03	0.02	1.9e-03	0.02	0.01	0	0.01	2.6e-03	1.0e-02	9.5e-02	1.7e-02
12	Eye	intron excision ratio	chr1_154443944_154447767	0.54	0.21	1.9e-03	0.06	0.05	0.02	0.07	4.8e-02	5.7e-02	1.7e-01	3.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	0.1	0.2	0.7	-0.5	-0.5	0.4	0.0	0.1	0.7	-0.4	-0.4	0.4	0.4	0.3	-0.9
Area under the delay curve	0.1	0.1	0.2	-0.2	-0.2	-0.1	0.3	-0.4	-0.3	0.3	0.3	-0.5	-0.5	-0.5	0.5
BMI with tail	0.1	0.2	0.4	0.2	0.2	-0.2	0.3	-0.4	-0.5	0.5	0.5	-0.4	-0.4	-0.5	0.7
BMI without tail	1.1	2.3	7.5	1.5	1.5	-1.4	0.1	-0.5	-2.4	1.1	1.1	-1.3	-1.3	-1.4	2.7
Body weight	0.8	3.1	9.3	1.4	1.4	-1.4	0.5	-0.9	-2.5	1.8	1.8	-1.6	-1.6	-1.9	3.1
Weight adjusted by age	0.5	0.6	2.2	0.9	0.9	-0.9	-0.3	0.1	-1.4	0.3	0.3	-0.3	-0.3	-0.2	1.5
Bone surface	0.6	1.0	1.6	1.2	1.2	-1.2	-1.2	1.1	-0.9	-0.9	-0.9	0.9	0.9	0.9	0.4
Bone volume	0.4	0.6	0.9	0.9	0.9	-0.9	-0.9	0.9	-0.6	-0.7	-0.7	0.8	0.8	0.7	0.2
Breakpoint value in progressive ratio session	0.2	0.2	0.6	-0.7	-0.7	0.7	0.2	-0.1	0.8	-0.2	-0.2	0.2	0.2	0.2	-0.6
Number of licking bursts	4.8	5.7	8.2	-2.4	-2.4	2.3	2.9	-2.8	1.3	2.5	2.5	-2.6	-2.6	-2.6	-0.2
Context. condit. distance diff. score	2.5	3.0	4.3	1.5	1.5	-1.5	-2.0	2.1	-0.6	-2.0	-2.0	2.0	2.0	2.0	-0.4
Locomotion velocity, session 1	0.4	0.4	1.4	-0.6	-0.6	0.7	0.1	0.1	1.1	-0.4	-0.4	0.4	0.4	0.4	-1.2
Locomotion distance, session 1	0.9	1.2	1.8	0.8	0.8	-0.8	-1.2	1.3	-0.1	-1.4	-1.4	1.4	1.4	1.3	-0.6
Locomotion velocity, session 2	0.0	0.0	0.1	0.3	0.3	-0.3	-0.2	0.2	-0.3	-0.1	-0.1	0.1	0.1	0.1	0.3
Locomotion distance, session 2	0.4	0.6	0.9	0.7	0.7	-0.7	-0.9	0.9	-0.2	-0.9	-0.9	0.9	0.9	0.9	-0.1
Locomotion velocity, session 3	1.0	1.1	1.9	0.6	0.6	-0.6	-1.1	1.2	0.2	-1.4	-1.4	1.4	1.4	1.2	-0.8
Locomotion distance, session 3	1.8	1.9	3.2	0.8	0.8	-0.8	-1.5	1.6	0.1	-1.8	-1.8	1.8	1.8	1.7	-0.9
Stereotopy head waving bouts, day 3	0.5	0.6	1.1	-0.4	-0.4	0.4	0.8	-0.9	-0.2	1.0	1.0	-1.0	-1.0	-1.0	0.7
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.1	0.1	-0.1	-0.4	0.4	0.1	-0.4	-0.4	0.4	0.4	0.5	-0.3
Locomotion velocity, session 7	0.2	0.2	0.5	-0.6	-0.6	0.6	0.4	-0.3	0.7	0.1	0.1	-0.1	-0.1	-0.0	-0.6
Locomotion distance, session 7	0.1	0.2	0.2	-0.4	-0.4	0.4	0.5	-0.5	0.2	0.4	0.4	-0.4	-0.4	-0.4	0.1
Stereotopy head waving bouts, day 7	2.5	2.8	4.0	1.6	1.6	-1.6	-2.0	2.0	-0.8	-1.9	-1.9	1.9	1.9	1.9	-0.1
Stereotopy head waving duration, day 7	2.8	3.4	4.8	2.0	2.0	-2.0	-2.2	2.1	-1.2	-1.9	-1.9	1.9	1.9	1.8	0.3
Locomotion velocity, session 8	0.7	0.8	1.2	0.9	0.9	-0.9	-1.1	1.1	-0.4	-1.0	-1.0	1.0	1.0	1.0	0.0
Locomotion distance, session 8	2.1	3.1	4.5	1.8	1.8	-1.8	-2.1	2.1	-0.9	-1.9	-1.9	1.9	1.9	1.9	0.0
Degree of sensitization distance	2.2	2.2	3.7	-0.3	-0.3	0.2	1.3	-1.5	-0.9	1.9	1.9	-1.9	-1.9	-1.8	1.7
Degree of sensitization stereotypy	5.4	5.9	8.4	2.4	2.4	-2.4	-2.9	2.9	-1.2	-2.7	-2.7	2.7	2.7	2.6	-0.0
Conditioned locomotion	0.1	0.1	0.4	-0.4	-0.4	0.4	0.1	0.0	0.6	-0.2	-0.2	0.2	0.2	0.2	-0.7
Cocaine response after cond. corrected	2.1	2.3	3.4	-1.2	-1.2	1.2	1.8	-1.8	0.3	1.8	1.8	-1.8	-1.8	-1.8	0.5
Cocaine response after cond. not corrected	0.5	0.6	0.8	-0.7	-0.7	0.7	0.9	-0.9	0.3	0.9	0.9	-0.9	-0.9	-0.9	0.2
Cocaine response before conditioning	2.2	2.7	4.1	1.2	1.2	-1.1	-1.9	2.0	-0.1	-2.0	-2.0	2.0	2.0	2.0	-0.8
Saline control response	1.5	1.9	3.8	2.0	2.0	-1.9	-1.4	1.3	-1.8	-0.7	-0.7	0.7	0.7	0.7	1.4
Bone: connectivity density	0.3	0.5	1.1	-0.2	-0.2	0.2	-0.4	0.5	0.7	-0.8	-0.8	0.8	0.8	0.8	-1.1
Bone: cortical apparent density	2.0	2.6	3.8	-1.4	-1.4	1.4	1.9	-2.0	0.5	1.8	1.8	-1.9	-1.9	-1.9	0.3
Bone: cortical area	0.3	0.4	1.0	0.9	0.9	-0.9	-0.5	0.4	-1.0	-0.1	-0.1	0.1	0.1	0.0	0.9
Bone: cortical porosity	1.2	1.3	2.2	0.7	0.7	-0.7	-1.3	1.4	0.0	-1.4	-1.4	1.4	1.4	1.5	-0.6
Bone: cortical porosity	1.1	1.2	2.0	0.6	0.6	-0.6	-1.2	1.3	0.1	-1.3	-1.3	1.4	1.4	1.4	-0.7
Bone: cortical thickness	0.1	0.1	0.3	-0.5	-0.5	0.5	0.4	-0.4	0.5	0.2	0.2	-0.2	-0.2	-0.3	-0.4
Bone: cortical thickness	0.2	0.3	0.5	0.2	0.2	-0.3	-0.5	0.6	0.1	-0.7	-0.7	0.7	0.7	0.6	-0.4
Bone: cortical tissue density	1.9	2.5	3.7	-1.4	-1.4	1.4	1.9	-1.9	0.6	1.8	1.8	-1.9	-1.9	-1.9	0.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.9	0.6	0.6	-0.6	-0.1	0.0	-0.9	0.3	0.3	-0.3	-0.3	-0.3	1.0
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.8	1.0	1.0	-1.0	-0.4	0.2	-1.3	0.2	0.2	-0.2	-0.2	-0.2	1.3
Condit. Reinf. active responses	0.1	0.1	0.3	0.2	0.2	-0.2	0.1	-0.2	-0.4	0.3	0.3	-0.3	-0.3	-0.3	0.5
Condit. Reinf. inactive responses	0.0	0.0	0.2	-0.3	-0.3	0.3	0.1	-0.1	0.3	-0.0	-0.0	0.0	0.0	-0.0	-0.4
Incentive salience index mean	0.2	0.3	0.8	0.7	0.7	-0.7	-0.3	0.2	-0.9	0.1	0.1	-0.1	-0.1	-0.2	0.9
Condit. Reinf. lever presses	0.1	0.1	0.2	0.5	0.5	-0.5	-0.3	0.2	-0.4	-0.1	-0.1	0.1	0.1	0.0	0.3
Condit. Reinf. active minus inactive responses	5.4	6.7	13.0	3.6	3.6	-3.6	-2.8	2.5	-3.2	-1.6	-1.6	1.5	1.5	1.5	2.2
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.6	1.6	1.6	-1.6	-1.4	1.3	-1.3	-0.9	-0.9	1.0	1.0	1.0	0.6
Condit. Reinf. active responses	6.7	9.4	18.8	4.3	4.3	-4.3	-3.2	2.8	-4.1	-1.7	-1.7	1.6	1.6	1.6	3.0
Condit. Reinf. inactive responses	3.8	4.7	9.6	3.1	3.1	-3.1	-2.2	1.8	-3.1	-1.0	-1.0	0.9	0.9	0.9	2.5
Condit. Reinf. lever presses	13.6	18.5	31.6	5.6	5.6	-5.6	-4.9	4.6	-4.5	-3.4	-3.4	3.3	3.3	3.3	2.5
Condit. Reinf. lever reinforcers received	7.7	10.8	21.0	4.5	4.5	-4.6	-3.5	3.1	-4.1	-2.0	-2.0	1.9	1.9	1.9	2.9
Conditioned reinforcement - actives	3.2	3.2	4.6	1.6	1.6	-1.8	-2.1	2.1	-0.5	-2.1	-2.1	2.0	2.0	2.2	-0.6
Conditioned reinforcement - inactives	0.2	0.2	0.6	-0.1	-0.1	0.2	0.5	-0.5	0.0	0.8	0.8	-0.5	-0.5	-0.3	0.1
Conditioned locomotion	3.2	3.9	6.4	1.4	1.4	-1.4	-2.2	2.3	-0.1	-2.5	-2.5	2.4	2.4	2.1	-1.2
Patch foraging indifference point 0 sec	3.5	5.7	8.4	2.7	2.7	-2.9	-2.8	2.7	-2.1	-2.2	-2.2	2.1	2.1	2.2	1.2
Patch foraging indifference point AUC	0.5	0.5	1.3	0.4	0.4	-0.5	0.3	-0.4	-0.9	0.7	0.7	-0.9	-0.9	-0.9	1.1
Delay disc. indifference point, 0s delay	0.5	0.6	1.4	0.9	0.9	-1.2	-0.9	0.8	-1.0	-0.5	-0.5	0.4	0.4	0.4	0.7
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.5	-0.5	0.2	0.1	-0.1	0.3	-0.1	-0.1	0.0	0.0	0.0	-0.2
Delay disc. indifference point, 2s delay	0.6	0.7	2.1	1.0	1.0	-1.3	-0.5	0.3	-1.4	0.0	0.0	-0.1	-0.1	-0.1	1.4
Delay disc. indifference point, 24s delay	0.7	0.7	1.4	-1.2	-1.2	1.0	1.0	-0.9	0.8	0.6	0.6	-0.7	-0.7	-0.7	-0.5
Delay disc. indifference point, 4s delay	0.7	0.7	2.3	1.1	1.1	-1.3	-0.4	0.2	-1.5	0.2	0.2	-0.3	-0.3	-0.3	1.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.2	-0.1	-0.1	-0.4	-0.1	0.0	-0.3	-0.0	-0.0	-0.1	-0.1	-0.1	0.4
Indifference point function ln k	1.9	2.7	4.9	0.7	0.7	-0.9	-1.7	1.9	0.3	-2.2	-2.2	2.1	2.1	2.1	-1.1
Indifference point function log k	1.9	2.7	4.9	0.7	0.7	-0.9	-1.7	1.9	0.3	-2.2	-2.2	2.1	2.1	2.1	-1.1
Patch foraging total patch changes 0 sec	2.7	4.4	6.9	2.5	2.5	-2.6	-2.5	2.3	-2.0	-1.9	-1.9	1.8	1.8	1.9	1.1
Patch foraging total patch changes 12 sec	1.0	1.3	3.5	1.6	1.6	-1.7	-0.8	0.6	-1.9	-0.1	-0.1	-0.1	-0.1	-0.0	1.7
Patch foraging total patch changes 18 sec	1.7	2.2	4.4	2.1	2.1	-2.0	-1.6	1.4	-1.8	-0.9	-0.9	0.9	0.9	0.9	1.3
Patch foraging total patch changes 24 sec	0.8	1.0	2.5	1.5	1.5	-1.5	-0.7	0.5	-1.6	0.1	0.1	-0.0	-0.0	0.1	1.3
Patch foraging total patch changes 6 sec	0.5	0.8	1.4	0.9	0.9	-1.2	-1.1	1.0	-0.6	-1.0	-1.0	0.8	0.8	0.8	0.2
Patch foraging time to switch 0 sec	2.7	4.1	7.1	-2.5	-2.5	2.7	2.4	-2.2	2.3	1.7	1.7	-1.6	-1.6	-1.5	-1.5
Patch foraging water rate 0 sec	2.6	4.2	6.1	2.3	2.3	-2.4	-2.5	2.4	-1.7	-2.0	-2.0	1.9	1.9	1.9	0.8
Patch foraging water rate 12 sec	2.0	3.0	4.4	1.7	1.7	-1.7	-2.1	2.1	-0.8	-1.9	-1.9	1.9	1.9	1.9	-0.1
Patch foraging water rate 18 sec	0.8	1.1	2.0	1.4	1.4	-1.4	-1.2	1.1	-1.1	-0.8	-0.8	0.9	0.9	0.8	0.5
Patch foraging water rate 24 sec	1.6	2.2	4.0	0.8	0.8	-0.8	-1.6	1.7	0.2	-2.0	-2.0	1.8	1.8	1.8	-1.1
Patch foraging water rate 6 sec	1.1	1.6	2.4	1.1	1.1	-0.9	-1.5	1.5	-0.2	-1.5	-1.5	1.5	1.5	1.5	-0.6
Seeking ratio, delayed vs. immediate footshock	1.0	1.1	3.0	-1.3	-1.3	1.7	1.0	-0.8	1.6	0.7	0.7	-0.2	-0.2	-0.2	-1.3
Distance traveled before self-admin	1.1	1.2	1.8	-1.3	-1.3	1.0	1.3	-1.3	0.6	0.9	0.9	-1.3	-1.3	-1.3	-0.1
Distance traveled after self-admin	0.8	0.9	3.5	-0.9	-0.9	1.1	0.2	0.1	1.6	-0.6	-0.6	0.7	0.7	0.7	-1.9
Extensor digitorum longus weight	0.3	1.3	2.3	0.0	0.0	-0.0	0.9	-1.1	-0.9	1.4	1.4	-1.4	-1.4	-1.5	1.5
Bone: elastic displacement	1.6	1.8	3.8	-1.9	-1.9	1.9	1.4	-1.2	1.8	0.7	0.7	-0.7	-0.7	-0.6	-1.4
Bone: elastic work	1.5	1.9	4.3	-2.0	-2.0	1.9	1.3	-1.0	2.1	0.4	0.4	-0.5	-0.5	-0.4	-1.7
Bone: endosteal estimation	1.0	2.1	5.7	2.1	2.1	-2.0	-1.1	0.8	-2.4	-0.0	-0.0	0.0	0.0	0.1	2.2
Bone: endosteal perimeter	1.2	2.5	6.1	2.3	2.3	-2.3	-1.4	1.2	-2.5	-0.4	-0.4	0.5	0.5	0.4	2.1
Epididymis fat weight	1.2	2.9	4.9	-0.2	-0.2	-0.0	1.4	-1.7	-1.1	2.2	2.2	-2.2	-2.2	-2.2	2.1
Delta time in closed arm before/after self-admin	3.6	3.5	6.3	-0.6	-0.6	0.4	1.8	-2.0	-0.8	2.4	2.4	-2.5	-2.5	-2.5	1.6
Delta time in open arm before/after self-admin	3.1	2.9	4.4	2.1	2.1	-1.9	-2.0	1.9	-1.5	-1.4	-1.4	1.6	1.6	1.6	0.9
Diff in mean of infusions in LGA sessions	3.3	3.6	5.1	-2.0	-2.0	2.0	2.3	-2.2	1.2	2.0	2.0	-2.0	-2.0	-2.0	-0.4
Delay discount exponential model param	0.1	0.1	0.2	0.3	0.3	0.1	-0.3	0.4	0.3	-0.4	-0.4	0.5	0.5	0.5	-0.5
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.3	-0.3	0.4	0.4	-0.4	-0.0	0.4	0.4	-0.3	-0.3	-0.3	0.3
Active lever presses in extinction session 6	3.8	3.7	7.2	0.7	0.7	-1.0	-2.1	2.2	0.2	-2.7	-2.7	2.4	2.4	2.4	-1.1
Bone: final force	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2	-0.2	0.1	0.2	0.2	-0.2	-0.2	-0.2	0.0
Bone: final moment	0.0	0.0	0.0	0.2	0.2	-0.2	-0.1	0.0	-0.2	0.0	0.0	-0.0	-0.0	-0.0	0.2
Food consumed during 24 hour testing period	3.6	4.4	6.3	2.0	2.0	-2.0	-2.5	2.5	-1.1	-2.3	-2.3	2.3	2.3	2.3	-0.0
Glucose	0.1	0.1	0.2	0.0	0.0	-0.1	-0.3	0.3	0.2	-0.4	-0.4	0.4	0.4	0.3	-0.4
Heart weight	1.1	1.6	2.3	1.3	1.3	-1.5	-1.5	1.4	-0.9	-1.2	-1.2	1.3	1.3	1.2	0.1
Delay discount hyperbolic model param	0.2	0.2	0.6	0.0	0.0	0.4	-0.2	0.3	0.6	-0.4	-0.4	0.5	0.5	0.5	-0.8
Intermittent access intake day 1-15 change	0.6	0.6	1.0	0.8	0.8	-0.8	-0.9	0.9	-0.3	-1.0	-1.0	0.8	0.8	0.8	-0.2
Intermittent access intake escalation	0.8	0.8	1.4	0.8	0.8	-0.9	-1.0	1.1	-0.3	-1.2	-1.2	0.9	0.9	0.9	-0.3
Intermittent access intake escalation 2	0.1	0.1	0.4	0.5	0.5	-0.7	-0.3	0.2	-0.6	-0.3	-0.3	-0.1	-0.1	-0.2	0.3
Intermitt. access day 1 inactive lever presses	0.4	0.5	1.0	-0.4	-0.4	0.6	0.8	-0.8	0.1	1.0	1.0	-0.8	-0.8	-0.5	0.2
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.8	0.4	0.4	-0.1	-0.5	0.6	0.3	-0.4	-0.4	0.8	0.8	0.9	-0.7
Intermitt. access escalation Index	0.3	0.3	0.6	0.6	0.6	-0.8	-0.6	0.6	-0.3	-0.6	-0.6	0.5	0.5	0.5	-0.0
Intermittent access day 1 total infusions	1.0	1.2	2.6	1.6	1.6	-1.3	-1.2	1.2	-1.0	-0.6	-0.6	1.0	1.0	1.0	0.5
Intermittent access day 15 total infusions	1.7	1.9	2.6	1.6	1.6	-1.4	-1.6	1.6	-0.7	-1.3	-1.3	1.4	1.4	1.5	-0.1
Intermittent access terminal intake (last 3 days)	1.4	1.5	2.3	1.5	1.5	-1.4	-1.4	1.4	-0.9	-1.1	-1.1	1.2	1.2	1.1	0.1
Intermittent access total infusions	0.9	1.1	2.1	1.5	1.5	-1.1	-1.1	1.1	-0.8	-0.7	-0.7	1.0	1.0	1.0	0.2
Intermittent access day 1 locomotion	0.2	0.3	0.5	0.4	0.4	-0.1	-0.5	0.6	0.2	-0.5	-0.5	0.7	0.7	0.5	-0.6
Intermittent access day 15 total locomotion	1.4	1.6	2.2	1.3	1.3	-1.2	-1.4	1.5	-0.3	-1.5	-1.5	1.4	1.4	1.1	-0.5
Intermittent access total locomotion	0.7	0.8	1.2	1.1	1.1	-0.9	-1.0	1.0	-0.5	-0.8	-0.8	1.0	1.0	0.7	-0.0
Intermittent access standard deviation	0.1	0.1	0.3	0.4	0.4	-0.4	-0.1	0.0	-0.5	0.1	0.1	-0.2	-0.2	-0.1	0.5
Left kidney weight	0.9	2.5	7.5	1.9	1.9	-2.4	-0.7	0.3	-2.7	0.4	0.4	-0.5	-0.5	-0.6	2.7
Right kidney weight	0.5	1.5	4.6	1.4	1.4	-1.8	-0.4	0.1	-2.1	0.4	0.4	-0.5	-0.5	-0.6	2.1
Cocaine induced anxiety	1.7	2.0	3.2	-1.8	-1.8	1.5	1.6	-1.6	1.2	1.2	1.2	-1.3	-1.3	-1.3	-0.6
Post-drug Anxiety	1.1	1.2	1.7	-1.1	-1.1	0.8	1.3	-1.3	0.4	1.2	1.2	-1.3	-1.3	-1.3	0.0
Baseline Anxiety	0.7	0.7	1.5	1.2	1.2	-1.1	-1.0	0.9	-1.1	-0.5	-0.5	0.5	0.5	0.5	0.8
Tail length	2.3	7.0	23.1	3.1	3.1	-3.1	-0.6	0.0	-4.5	1.4	1.4	-1.5	-1.5	-1.6	4.8
Length with tail	1.3	4.6	14.7	2.1	2.1	-2.0	0.1	-0.6	-3.4	1.9	1.9	-1.7	-1.7	-1.8	3.8
Length without tail	0.2	0.3	0.5	-0.7	-0.7	0.7	0.6	-0.6	0.6	0.7	0.7	-0.3	-0.3	-0.4	-0.5
Times rat made contact with spout	0.7	0.8	1.4	-0.3	-0.3	0.1	0.8	-1.0	-0.5	1.1	1.1	-1.2	-1.2	-1.2	0.9
Lifetime Intake	1.2	1.4	2.7	1.6	1.6	-1.2	-1.3	1.3	-0.9	-0.8	-0.8	1.2	1.2	1.2	0.2
Liver weight, left	1.3	2.1	3.6	-0.3	-0.3	0.4	1.4	-1.6	-0.7	1.9	1.9	-1.9	-1.9	-1.8	1.5
Liver weight, right	2.9	4.9	8.4	-0.6	-0.6	0.7	2.2	-2.4	-0.9	2.9	2.9	-2.9	-2.9	-2.8	2.1
Locomotor activity	0.6	0.9	1.6	0.8	0.8	-1.3	-1.2	1.1	-0.6	-1.2	-1.2	0.8	0.8	0.8	0.1
Locomotor testing distance	1.5	2.5	5.4	1.9	1.9	-2.3	-1.8	1.6	-1.8	-1.3	-1.3	1.1	1.1	1.1	1.0
Locomotor testing rearing	0.7	1.0	3.2	1.3	1.3	-1.6	-0.6	0.3	-1.8	0.1	0.1	-0.3	-0.3	-0.3	1.7
Locomotion in novel chamber	1.2	1.5	4.0	0.2	0.2	-0.6	-1.2	1.3	0.3	-2.0	-2.0	1.3	1.3	1.3	-1.2
Locomotion in novel chamber post-restriction	2.3	2.8	4.1	1.4	1.4	-1.3	-1.9	2.0	-0.4	-2.0	-2.0	2.0	2.0	1.9	-0.5
Fecal boli incidents, locomotor time 1	1.2	1.4	2.4	0.6	0.6	-0.6	-1.3	1.3	0.1	-1.5	-1.5	1.5	1.5	1.4	-0.7
Change in fecal boli incidents, locomotor task	1.1	1.1	1.5	-0.9	-0.9	1.2	1.2	-1.2	0.7	1.1	1.1	-1.1	-1.1	-1.1	-0.4
Time >=10cm from walls, locomotor time 1	2.1	2.1	3.0	1.3	1.3	-1.2	-1.7	1.7	-0.4	-1.7	-1.7	1.7	1.7	1.7	-0.2
Bouts of movement, locomotor time 1	0.3	0.3	0.4	0.5	0.5	-0.3	-0.6	0.6	-0.1	-0.7	-0.7	0.7	0.7	0.6	-0.1
Total resting periods, locomotor time 1	0.4	0.5	0.9	0.2	0.2	0.2	-0.5	0.7	0.5	-0.9	-0.9	0.9	0.9	0.9	-0.7
Rest time, locomotor task time 1	0.2	0.2	0.6	-0.3	-0.3	0.6	-0.1	0.2	0.8	-0.4	-0.4	0.5	0.5	0.5	-0.8
Distance moved, locomotor task time 1	0.5	0.6	1.8	0.5	0.5	-0.8	0.1	-0.3	-1.2	0.6	0.6	-0.8	-0.8	-0.8	1.3
Vertical activity count, locomotor time 1	0.4	0.4	1.1	0.7	0.7	-0.9	-0.2	0.1	-1.1	0.3	0.3	-0.4	-0.4	-0.2	1.0
Time >=10cm from walls, locomotor time 2	1.2	1.2	2.4	1.6	1.6	-1.3	-1.3	1.2	-1.0	-0.8	-0.8	0.8	0.8	1.0	0.5
Bouts of movement, locomotor time 2	0.4	0.5	1.2	0.9	0.9	-0.7	-0.1	-0.1	-1.1	0.4	0.4	-0.5	-0.5	-0.6	1.0
Total resting periods, locomotor time 2	0.4	0.4	0.8	0.6	0.6	-0.3	0.2	-0.4	-0.8	0.7	0.7	-0.7	-0.7	-0.8	0.9
Rest time, locomotor task time 2	2.6	3.0	5.3	-2.1	-2.1	2.3	2.0	-1.8	1.8	1.6	1.6	-1.4	-1.4	-1.3	-0.9
Distance moved, locomotor task time 2	2.5	2.9	5.7	2.3	2.3	-2.4	-1.9	1.7	-2.1	-1.2	-1.2	1.1	1.1	1.1	1.4
Vertical activity count, locomotor time 2	1.0	1.1	2.9	1.5	1.5	-1.7	-0.9	0.7	-1.7	-0.2	-0.2	0.1	0.1	0.2	1.3
Light reinforcement 1	2.0	3.7	5.3	-2.3	-2.3	2.3	2.2	-2.2	1.4	1.9	1.9	-1.8	-1.8	-1.8	-0.3
Light reinforcement 2	0.3	0.3	0.9	-0.9	-0.9	0.8	0.3	-0.2	0.9	-0.1	-0.1	0.1	0.1	0.1	-0.8
Bone: marrow area	0.8	1.8	5.1	1.9	1.9	-1.8	-0.9	0.6	-2.3	0.1	0.1	-0.1	-0.1	-0.0	2.1
Bone: maximum diameter	1.2	2.3	4.6	2.1	2.1	-2.2	-1.5	1.3	-2.1	-0.7	-0.7	0.7	0.7	0.7	1.7
Bone: maximum force	0.0	0.0	0.0	0.2	0.2	-0.2	-0.1	0.1	-0.2	-0.0	-0.0	0.0	0.0	0.0	0.2
Bone: maximum moment	0.1	0.1	0.2	0.5	0.5	-0.5	-0.4	0.3	-0.4	-0.2	-0.2	0.2	0.2	0.2	0.3
Mean time between licks in bursts	3.7	5.2	13.4	3.2	3.2	-3.3	-1.9	1.4	-3.7	-0.3	-0.3	0.3	0.3	0.3	3.3
Mean num. licks in bursts	3.8	4.5	6.5	2.2	2.2	-2.2	-2.6	2.5	-1.4	-2.2	-2.2	2.2	2.2	2.2	0.4
Cd content in liver	0.9	0.9	1.7	-0.5	-0.5	0.5	1.0	-1.1	-0.2	1.2	1.2	-1.2	-1.2	-1.3	0.7
Co content in liver	1.1	1.3	3.2	1.7	1.7	-1.7	-1.0	0.8	-1.8	-0.3	-0.3	0.3	0.3	0.3	1.5
Cu content in liver	0.7	0.9	2.7	1.3	1.3	-1.3	-0.6	0.4	-1.6	0.2	0.2	-0.2	-0.2	-0.2	1.6
Fe content in liver	0.1	0.1	0.1	-0.1	-0.1	0.1	0.3	-0.3	-0.1	0.3	0.3	-0.3	-0.3	-0.3	0.3
K content in liver	0.4	0.4	0.6	-0.3	-0.3	0.3	0.6	-0.7	-0.2	0.8	0.8	-0.7	-0.7	-0.7	0.6
Mg content in liver	0.1	0.1	0.2	0.5	0.5	-0.5	-0.3	0.3	-0.5	-0.1	-0.1	0.2	0.2	0.2	0.4
Mn content in liver	1.2	1.3	3.5	-1.7	-1.7	1.7	0.9	-0.7	1.9	0.1	0.1	-0.1	-0.1	-0.1	-1.7
Na content in liver	0.3	0.3	0.6	0.4	0.4	-0.4	-0.6	0.6	-0.2	-0.6	-0.6	0.6	0.6	0.8	-0.1
Rb content in liver	0.6	0.8	1.5	1.2	1.2	-1.2	-1.0	0.9	-1.0	-0.6	-0.6	0.6	0.6	0.5	0.7
Se content in liver	2.7	3.3	5.6	-2.4	-2.4	2.4	2.1	-1.9	2.0	1.4	1.4	-1.4	-1.4	-1.3	-1.2
Sr content in liver	0.2	0.2	0.5	-0.2	-0.2	0.2	-0.2	0.3	0.6	-0.5	-0.5	0.5	0.5	0.6	-0.7
Zn content in liver	3.9	4.3	6.7	2.6	2.6	-2.6	-2.4	2.3	-2.0	-1.7	-1.7	1.8	1.8	1.8	1.1
Bone: minimum diameter	0.8	1.5	5.3	1.2	1.2	-1.2	0.0	-0.3	-2.0	1.0	1.0	-1.0	-1.0	-1.0	2.3
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.1	0.1	-0.1	0.2	-0.3	-0.4	0.4	0.4	-0.4	-0.4	-0.4	0.5
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.5	-0.5	0.5	0.5	-0.5	0.3	0.4	0.4	-0.4	-0.4	-0.5	-0.0
Total zone transitions, hab. session 1	0.3	0.4	1.1	-0.2	-0.2	0.2	-0.4	0.5	0.8	-0.7	-0.7	0.7	0.7	0.8	-1.1
Total locomotion distance, hab. session 1	1.3	1.9	3.2	-0.5	-0.5	0.5	1.4	-1.5	-0.6	1.8	1.8	-1.8	-1.8	-1.8	1.2
Locomotion velocity, hab. session 1	0.7	1.1	1.8	-0.3	-0.3	0.3	1.0	-1.1	-0.5	1.4	1.4	-1.4	-1.4	-1.3	1.0
Time in familiar zone, hab. session 2	1.1	1.2	2.2	1.5	1.5	-1.5	-1.2	1.1	-1.3	-0.7	-0.7	0.7	0.7	0.7	0.9
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.8	-0.8	0.8	0.4	-0.4	0.8	0.1	0.1	-0.1	-0.1	-0.1	-0.7
Total zone transitions, hab. session 2	1.6	2.0	3.0	1.1	1.1	-1.1	-1.7	1.7	-0.2	-1.7	-1.7	1.7	1.7	1.7	-0.5
Total locomotion distance, hab. session 2	0.7	0.9	2.6	0.4	0.4	-0.5	0.4	-0.6	-1.2	1.1	1.1	-1.1	-1.1	-1.0	1.6
Locomotion velocity, hab. session 2	0.9	1.2	3.1	0.3	0.3	-0.4	0.6	-0.9	-1.3	1.3	1.3	-1.3	-1.3	-1.3	1.8
Novel to familiar place preference ratio	0.1	0.1	0.1	0.2	0.2	-0.2	-0.3	0.3	-0.1	-0.3	-0.3	0.3	0.3	0.3	-0.0
Novelty place preference	0.1	0.1	0.1	0.2	0.2	-0.2	-0.3	0.3	-0.1	-0.3	-0.3	0.3	0.3	0.3	-0.1
Time in novel zone, NPP test	0.2	0.2	0.3	0.4	0.4	-0.4	-0.5	0.5	-0.2	-0.5	-0.5	0.5	0.5	0.5	-0.0
Total zone transitions, NPP test	0.4	0.5	0.9	0.3	0.3	-0.3	-0.7	0.8	0.3	-1.0	-1.0	1.0	1.0	0.9	-0.7
Total locomotion distance, NPP test	0.9	1.2	2.0	-0.2	-0.2	0.2	1.0	-1.2	-0.6	1.4	1.4	-1.4	-1.4	-1.4	1.1
Locomotion velocity, NPP test	1.2	1.6	2.8	-0.5	-0.5	0.5	1.3	-1.5	-0.4	1.7	1.7	-1.7	-1.7	-1.6	1.0
Intraocular pressure	0.5	0.6	1.1	0.2	0.2	-0.1	-0.7	0.8	0.4	-1.0	-1.0	1.0	1.0	1.0	-1.0
Delta distance traveled before/after self-admin	1.8	1.9	3.5	1.1	1.1	-0.5	-1.4	1.6	0.2	-1.4	-1.4	1.9	1.9	1.9	-1.0
Delta ambulatory time before/after self-admin	2.1	2.3	4.5	1.0	1.0	-0.4	-1.5	1.7	0.5	-1.6	-1.6	2.1	2.1	2.1	-1.3
Parametrial fat weight	1.3	2.6	4.2	-0.8	-0.8	0.8	1.7	-1.8	-0.4	2.1	2.1	-2.0	-2.0	-2.0	1.4
Pavlov. Cond. lever latency	1.0	1.3	2.2	-1.5	-1.5	1.5	1.3	-1.2	1.2	0.9	0.9	-0.9	-0.9	-0.8	-0.8
Pavlov. Cond. magazine entry latency	2.3	3.0	5.2	2.3	2.3	-2.3	-2.0	1.8	-1.9	-1.3	-1.3	1.3	1.3	1.2	1.3
Pavlov. Cond. change in total contacts	1.1	1.2	2.1	1.5	1.5	-1.5	-1.2	1.1	-1.3	-0.8	-0.8	0.8	0.8	0.8	0.9
Pavlov. Cond. index score	2.4	3.0	5.3	2.3	2.3	-2.3	-1.9	1.8	-2.0	-1.2	-1.2	1.2	1.2	1.1	1.4
Pavlov. Cond. latency score	2.3	2.9	5.1	2.3	2.3	-2.3	-1.9	1.8	-1.9	-1.2	-1.2	1.2	1.2	1.2	1.3
Pavlov. Cond. lever contacts	1.0	1.2	2.4	1.5	1.5	-1.5	-1.1	1.0	-1.4	-0.6	-0.6	0.6	0.6	0.5	1.1
Pavlov. Cond. magazine entry number	2.8	3.5	5.5	-2.3	-2.3	2.3	2.2	-2.0	1.9	1.5	1.5	-1.5	-1.5	-1.5	-1.2
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.7	-1.3	-1.3	1.3	1.1	-1.0	1.2	0.7	0.7	-0.7	-0.7	-0.7	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	4.2	2.0	2.0	-2.0	-1.7	1.6	-1.7	-1.1	-1.1	1.1	1.1	1.1	1.3
Pavlov. Cond. response bias	1.0	1.2	2.2	1.5	1.5	-1.5	-1.2	1.0	-1.4	-0.6	-0.6	0.6	0.6	0.6	1.1
Pavlov. Cond. lever latency	14.2	19.1	30.8	-5.5	-5.5	5.5	5.1	-4.8	4.3	3.7	3.7	-3.6	-3.6	-3.6	-2.3
Pavlov. Cond. magazine entry latency	3.7	4.2	6.1	2.2	2.2	-2.2	-2.5	2.4	-1.4	-2.1	-2.1	2.1	2.1	2.1	0.3
Pavlov. Cond. change in total contacts	11.2	15.5	23.0	4.8	4.8	-4.8	-4.6	4.4	-3.5	-3.5	-3.5	3.5	3.5	3.5	1.6
Pavlov. Cond. index score	11.2	14.4	22.2	4.7	4.7	-4.7	-4.5	4.2	-3.5	-3.3	-3.3	3.2	3.2	3.2	1.7
Pavlov. Cond. latency score	10.1	12.6	19.1	4.4	4.4	-4.4	-4.2	4.0	-3.2	-3.1	-3.1	3.1	3.1	3.1	1.5
Pavlov. Cond. lever contacts	14.7	20.1	32.4	5.7	5.7	-5.7	-5.2	4.9	-4.4	-3.8	-3.8	3.7	3.7	3.7	2.3
Pavlov. Cond. magazine entry number	6.5	7.9	11.5	-3.1	-3.1	3.1	3.4	-3.3	1.9	2.8	2.8	-2.8	-2.8	-2.8	-0.5
Pavlov. Cond. intertrial magazine entries	0.7	0.9	2.6	0.4	0.4	-0.5	0.5	-0.7	-1.2	1.1	1.1	-1.1	-1.1	-1.1	1.6
Pavlov. Cond. lever-magazine prob. diff.	10.4	13.3	21.1	4.6	4.6	-4.6	-4.3	4.0	-3.5	-3.1	-3.1	3.0	3.0	3.0	1.8
Pavlov. Cond. response bias	15.1	20.5	31.8	5.6	5.6	-5.6	-5.3	5.0	-4.2	-3.9	-3.9	3.9	3.9	3.9	2.1
Time in closed arm before self-admin	3.9	4.4	7.7	0.8	0.8	-0.7	-2.1	2.4	0.7	-2.8	-2.8	2.7	2.7	2.7	-1.8
Time in closed arm after self-admin	0.7	0.8	2.7	-1.1	-1.1	1.1	0.6	-0.4	1.5	-0.1	-0.1	0.0	0.0	0.0	-1.7
Time in open arm before self-admin	4.4	4.8	6.9	-2.3	-2.3	1.8	2.6	-2.6	0.8	2.2	2.2	-2.5	-2.5	-2.5	0.3
Time in open arm after self-admin	0.7	0.8	3.4	0.7	0.7	-0.8	0.0	-0.2	-1.5	0.6	0.6	-0.7	-0.7	-0.7	1.8
Bone: periosteal estimation	0.8	1.7	4.5	1.9	1.9	-1.9	-1.1	0.8	-2.1	-0.1	-0.1	0.1	0.1	0.2	1.9
Bone: periosteal perimeter	1.0	1.6	3.7	1.8	1.8	-1.8	-1.2	1.0	-1.9	-0.4	-0.4	0.5	0.5	0.4	1.6
Bone: post-yield work	0.1	0.2	0.3	0.5	0.5	-0.5	-0.5	0.5	-0.4	-0.4	-0.4	0.4	0.4	0.4	0.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.1	-0.1	0.5	0.3	-0.3	0.4	0.4	0.4	-0.1	-0.1	-0.1	-0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.1	-0.1	0.4	0.4	-0.3	0.2	0.5	0.5	-0.2	-0.2	-0.2	-0.2
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.9	1.0	1.0	-0.5	-0.5	0.5	-0.6	0.1	0.1	0.5	0.5	0.6	0.4
Progressive ratio test 2 active lever presses	0.7	0.8	2.2	1.2	1.2	-1.5	-0.9	0.8	-1.1	-0.5	-0.5	0.5	0.5	0.4	0.7
Progressive ratio test 2 breakpoint	0.8	0.9	2.4	1.3	1.3	-1.5	-0.9	0.8	-1.2	-0.5	-0.5	0.5	0.5	0.4	0.7
Progressive ratio test 2 inactive lever presses	1.0	1.1	1.6	1.1	1.1	-1.1	-1.2	1.2	-0.4	-0.9	-0.9	1.2	1.2	1.2	-0.2
Incentive Sensitization - Responses	1.7	1.7	4.8	1.7	1.7	-2.2	-1.4	1.2	-1.7	-0.9	-0.9	0.6	0.6	0.5	1.0
Incentive Sensitization - Breakpoint	1.6	1.6	4.3	1.6	1.6	-2.1	-1.4	1.2	-1.5	-1.0	-1.0	0.7	0.7	0.6	0.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	-0.7	-0.7	0.4	0.1	-0.1	0.4	-0.3	-0.3	0.1	0.1	0.1	-0.2
Progressive ratio	0.2	0.2	0.4	-0.1	-0.1	-0.1	-0.3	0.4	0.3	-0.5	-0.5	0.5	0.5	0.6	-0.5
Food seeking constrained by brief footshock	0.8	1.0	2.9	1.3	1.3	-1.5	-0.7	0.5	-1.7	-0.1	-0.1	0.0	0.0	-0.1	1.6
Seeking ratio, punishment vs. effort	0.9	1.0	3.4	1.3	1.3	-1.2	-0.3	0.0	-1.7	0.5	0.5	-0.5	-0.5	-0.7	1.8
Retroperitoneal fat weight	5.2	17.2	30.5	-1.6	-1.6	1.6	4.2	-4.7	-1.3	5.5	5.5	-5.3	-5.3	-5.3	3.4
Reaction time number correct	0.8	1.1	2.1	-0.5	-0.5	0.4	-0.6	0.8	1.1	-1.4	-1.4	1.2	1.2	1.1	-1.4
Reaction time mean minus median	0.5	0.7	1.6	1.1	1.1	-1.2	-0.8	0.7	-1.2	-0.3	-0.3	0.4	0.4	0.4	1.1
Reaction time mean minus median AUC	0.9	1.2	1.7	1.2	1.2	-1.2	-1.3	1.2	-0.9	-1.0	-1.0	1.0	1.0	1.1	0.5
Reaction time num false alarms	2.0	2.7	3.9	-1.7	-1.7	1.4	1.9	-2.0	0.6	1.8	1.8	-1.9	-1.9	-1.9	0.3
Reaction time num false alarms AUC	1.0	1.3	1.9	-1.3	-1.3	1.1	1.4	-1.4	0.6	1.2	1.2	-1.2	-1.2	-1.2	0.1
Reaction time trials correct on left	0.8	1.1	2.1	-0.5	-0.5	0.4	-0.6	0.8	1.1	-1.4	-1.4	1.2	1.2	1.1	-1.4
Reaction time trials on left	0.8	1.1	2.1	-0.5	-0.5	0.4	-0.6	0.8	1.1	-1.4	-1.4	1.2	1.2	1.1	-1.4
Reaction time mean	0.8	1.2	1.8	-0.8	-0.8	0.7	1.2	-1.3	0.0	1.3	1.3	-1.3	-1.3	-1.3	0.6
Reaction time mean AUC	1.0	1.3	1.9	-1.1	-1.1	1.1	1.4	-1.4	0.4	1.3	1.3	-1.2	-1.2	-1.2	0.2
Median of all reaction times	1.3	1.8	2.6	-1.4	-1.4	1.3	1.6	-1.6	0.6	1.5	1.5	-1.4	-1.4	-1.4	0.1
Reaction time omissions	0.4	0.5	0.8	-0.5	-0.5	0.4	0.8	-0.8	-0.1	0.9	0.9	-0.8	-0.8	-0.9	0.5
Reaction time false alarm rate	1.6	2.2	3.4	-1.1	-1.1	0.9	1.7	-1.8	0.1	1.9	1.9	-1.8	-1.8	-1.8	0.7
Reaction time premature initiation rate	1.5	2.0	6.2	1.9	1.9	-1.8	-0.6	0.3	-2.5	0.6	0.6	-0.5	-0.5	-0.4	2.5
Reaction time premature initiations	0.8	1.1	2.5	1.5	1.5	-1.4	-1.0	0.8	-1.6	-0.4	-0.4	0.4	0.4	0.4	1.3
Std. dev. reaction times	0.5	0.8	2.5	0.7	0.7	-0.8	0.1	-0.3	-1.4	0.7	0.7	-0.8	-0.8	-0.8	1.6
Reaction time trials completed	0.8	1.1	2.1	-0.5	-0.5	0.4	-0.6	0.8	1.1	-1.4	-1.4	1.2	1.2	1.1	-1.4
Reaction time trials AUC	0.6	0.8	1.7	-0.5	-0.5	0.3	-0.6	0.7	0.9	-1.3	-1.3	1.0	1.0	0.9	-1.2
Run reversals in cocaine runway, females	3.6	3.5	6.8	0.3	0.3	-0.0	1.4	-1.7	-1.6	2.5	2.5	-2.2	-2.2	-2.2	2.6
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.1	-0.1	0.4	0.2	-0.1	0.4	0.2	0.2	0.1	0.1	0.0	-0.3
Latency to leave start box in cocaine runway	3.1	3.4	5.4	-1.5	-1.5	1.6	2.1	-2.2	0.4	2.3	2.3	-2.1	-2.1	-2.0	0.5
Latency to leave start box in cocaine runway, F	3.2	3.5	6.3	-1.1	-1.1	1.2	2.0	-2.2	-0.2	2.5	2.5	-2.3	-2.3	-2.2	1.3
Latency to leave start box in cocaine runway, M	0.4	0.4	1.0	-0.9	-0.9	0.9	0.4	-0.3	1.0	0.0	0.0	-0.0	-0.0	0.0	-0.9
Std. dev. time between licks in bursts	1.5	1.8	5.9	1.6	1.6	-1.7	-0.4	0.1	-2.4	0.6	0.6	-0.7	-0.7	-0.7	2.4
Total sessions with >9 infusions	2.7	3.0	4.2	2.0	2.0	-1.5	-2.0	2.0	-0.8	-1.6	-1.6	2.0	2.0	2.0	-0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.4	-0.2	-0.2	0.7	0.2	-0.2	0.5	0.4	0.4	0.1	0.1	0.2	-0.4
Short access day 10 total inactive lever presses	0.1	0.1	0.3	-0.5	-0.5	0.4	0.2	-0.2	0.4	-0.1	-0.1	-0.2	-0.2	-0.0	-0.5
Short access day 1 total infusions	2.1	2.2	4.1	2.0	2.0	-1.9	-1.7	1.6	-1.4	-1.1	-1.1	1.3	1.3	1.3	0.8
Short access day 10 total infusions	1.1	1.2	2.9	1.7	1.7	-1.5	-1.1	1.0	-1.3	-0.4	-0.4	0.6	0.6	0.6	0.8
Short access total infusions	0.9	1.0	2.3	1.5	1.5	-1.1	-1.1	1.0	-1.0	-0.3	-0.3	0.8	0.8	0.9	0.7
Short access day 1 locomotion	2.4	2.5	4.3	1.2	1.2	-1.1	-1.8	1.9	-0.1	-1.9	-1.9	2.1	2.1	1.9	-0.7
Short access day 10 total locomotion	0.3	0.3	1.1	0.7	0.7	-1.1	-0.5	0.4	-0.6	-0.5	-0.5	0.1	0.1	-0.0	0.2
Short access total locomotion	0.2	0.2	0.3	0.5	0.5	-0.5	-0.5	0.5	-0.2	-0.5	-0.5	0.5	0.5	0.2	-0.1
One hour access (0.3 mA shock)	1.7	2.0	3.7	1.9	1.9	-1.7	-1.6	1.6	-1.2	-1.3	-1.3	1.2	1.2	1.3	0.3
Compulsive drug intake	0.3	0.3	0.5	-0.6	-0.6	0.1	-0.2	0.3	0.6	-0.7	-0.7	0.5	0.5	0.7	-0.7
One hour access (shock baseline)	1.2	1.4	3.4	1.8	1.8	-1.5	-1.3	1.2	-1.2	-0.8	-0.8	0.8	0.8	0.7	0.5
Social response proportion	0.6	0.6	1.2	-0.4	-0.4	0.4	0.9	-0.9	-0.0	1.0	1.0	-1.1	-1.1	-1.0	0.3
Social responses	1.0	1.3	2.7	-0.1	-0.1	0.2	1.0	-1.2	-0.7	1.6	1.6	-1.5	-1.5	-1.4	1.1
Social time	2.0	2.7	5.6	-2.2	-2.2	2.4	1.8	-1.6	2.0	1.2	1.2	-1.0	-1.0	-1.0	-1.3
Soleus weight	0.9	2.7	6.1	0.4	0.4	-0.4	1.1	-1.4	-1.7	2.0	2.0	-2.0	-2.0	-2.0	2.5
Bone: stiffness	0.4	0.6	1.1	-0.2	-0.2	0.3	0.8	-0.9	-0.2	1.0	1.0	-1.0	-1.0	-1.0	0.6
Tibialis anterior weight	0.1	0.4	1.5	0.7	0.7	-0.7	-0.1	-0.1	-1.1	0.5	0.5	-0.4	-0.4	-0.5	1.2
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.2	-0.2	0.2	0.0	0.0	0.4	-0.2	-0.2	0.2	0.2	0.2	-0.5
Time to tail flick, vehicle, after self-admin	2.7	2.9	4.4	1.7	1.7	-1.2	-2.0	2.0	-0.6	-1.7	-1.7	2.1	2.1	2.1	-0.1
Time to tail flick, test, before self-admin	0.3	0.3	0.9	0.8	0.8	-0.6	-0.3	0.2	-0.9	0.2	0.2	-0.1	-0.1	-0.1	1.0
Time to tail flick, test, after self-admin	0.7	0.7	2.1	0.9	0.9	-0.8	-0.0	-0.2	-1.4	0.7	0.7	-0.6	-0.6	-0.6	1.4
Delta time to tail flick, vehicle, before/after SA	1.7	1.7	2.4	1.5	1.5	-0.9	-1.5	1.5	-0.7	-1.0	-1.0	1.6	1.6	1.6	0.3
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	-0.4	-0.4	0.4	0.6	-0.6	0.2	0.6	0.6	-0.6	-0.6	-0.6	-0.0
Tibia length	1.9	5.5	7.9	1.9	1.9	-1.9	-2.7	2.8	-0.5	-2.8	-2.8	2.8	2.8	2.7	-0.8
Ambulatory time before self-admin	1.1	1.1	1.8	-1.3	-1.3	1.1	1.2	-1.2	1.0	0.7	0.7	-1.0	-1.0	-1.0	-0.6
Ambulatory time after self-admin	1.3	1.4	5.4	-0.6	-0.6	1.0	-0.2	0.5	1.8	-1.0	-1.0	1.2	1.2	1.2	-2.3
Bone: tissue strength	0.9	0.9	2.7	-0.8	-0.8	0.7	-0.1	0.4	1.4	-0.8	-0.8	0.9	0.9	0.8	-1.6
Total heroin consumption	0.4	0.5	0.8	0.4	0.4	-0.3	-0.8	0.8	-0.1	-0.9	-0.9	0.9	0.9	0.9	-0.1
Bone: trabecular number	0.6	1.0	2.7	-1.4	-1.4	1.4	0.8	-0.6	1.6	0.1	0.1	-0.1	-0.1	-0.2	-1.5
Bone: trabecular spacing	0.7	0.9	1.3	1.1	1.1	-1.1	-1.1	1.1	-0.7	-0.9	-0.9	0.9	0.9	1.0	0.3
Bone: trabecular thickness	0.2	0.3	0.4	-0.5	-0.5	0.4	0.6	-0.6	0.2	0.6	0.6	-0.6	-0.6	-0.6	0.2
Bone: trabecular tissue density	2.2	3.1	5.3	-0.8	-0.8	0.7	1.8	-2.0	-0.5	2.2	2.2	-2.3	-2.3	-2.3	1.5
Water consumed over 24 hours	0.4	0.5	1.0	-1.0	-1.0	1.0	0.8	-0.7	1.0	0.4	0.4	-0.4	-0.4	-0.4	-0.9
Number of responses in last shaping day	0.3	0.3	0.9	0.7	0.7	-0.9	-0.3	0.1	-0.9	0.1	0.1	-0.3	-0.3	-0.3	0.9