Hub : Genes

Plxdc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Plxdc1	0.05	0.04	3.5e-05	0.04	0.04	0.03	0.04	7.6e-05	7.3e-05	3.5e-04	1.8e-04
2	pVTA	intron excision ratio	chr10_82956547_82956821	0.39	0.22	9.6e-03	0.03	0.02	0	0.02	1.6e-02	5.3e-02	2.4e-01	5.5e-02
3	Brain	mRNA stability	Plxdc1	0.15	0.15	1.0e-05	0.06	0.04	0.06	0.06	2.4e-06	4.4e-05	4.0e-06	3.6e-06
4	Adipose	gene expression	Plxdc1	0.37	0.27	8.2e-13	0.11	0.11	0.11	0.11	4.7e-12	9.2e-12	4.5e-12	8.6e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.3	3.9	4.8	1.9	1.8	-1.9	-2.2
Area under the delay curve	0.8	0.9	1.2	1.0	0.7	-1.0	-1.1
BMI with tail	1.4	4.7	5.6	-2.3	-2.4	2.3	1.5
BMI without tail	0.0	0.1	0.2	-0.4	-0.2	0.1	-0.0
Body weight	5.0	21.1	26.0	-5.1	-4.4	4.8	4.0
Weight adjusted by age	0.4	0.4	0.9	-0.4	-1.0	0.3	0.6
Bone surface	0.0	0.0	0.1	-0.1	0.1	-0.3	-0.0
Bone volume	0.1	0.2	0.3	0.4	0.4	-0.6	-0.4
Breakpoint value in progressive ratio session	0.9	0.9	1.4	-1.1	-0.1	1.2	1.1
Number of licking bursts	0.4	0.5	0.7	0.8	0.4	-0.6	-0.9
Context. condit. distance diff. score	0.9	1.0	2.1	-0.7	-1.4	1.0	0.7
Locomotion velocity, session 1	0.5	0.6	0.9	-1.0	-0.4	0.7	0.9
Locomotion distance, session 1	2.4	3.1	5.1	-2.3	-1.2	1.6	1.7
Locomotion velocity, session 2	0.4	0.4	0.8	-0.9	-0.3	0.7	0.6
Locomotion distance, session 2	0.5	0.6	1.4	-1.2	0.2	0.5	0.9
Locomotion velocity, session 3	0.1	0.1	0.2	-0.4	-0.1	0.4	0.0
Locomotion distance, session 3	0.4	0.4	0.6	-0.8	-0.6	0.6	0.6
Stereotopy head waving bouts, day 3	3.5	4.1	5.2	2.1	1.8	-1.9	-2.3
Stereotopy head waving duration, day 3	0.5	0.6	1.2	0.8	0.4	-0.5	-1.1
Locomotion velocity, session 7	0.8	0.8	1.0	-0.9	-1.0	1.0	0.8
Locomotion distance, session 7	0.1	0.2	0.4	-0.3	-0.3	0.4	0.6
Stereotopy head waving bouts, day 7	1.0	1.1	1.9	1.1	0.7	-0.9	-1.4
Stereotopy head waving duration, day 7	0.3	0.3	0.6	0.5	0.3	-0.5	-0.8
Locomotion velocity, session 8	7.2	8.6	9.8	-3.0	-3.0	3.1	2.6
Locomotion distance, session 8	1.3	1.9	2.5	-1.6	-1.2	1.2	1.5
Degree of sensitization distance	0.5	0.5	0.7	-0.5	-0.8	0.9	0.7
Degree of sensitization stereotypy	1.5	1.6	2.3	1.4	0.8	-1.2	-1.5
Conditioned locomotion	0.1	0.1	0.2	0.3	0.4	-0.3	-0.4
Cocaine response after cond. corrected	1.8	2.0	2.7	1.6	1.4	-1.6	-1.0
Cocaine response after cond. not corrected	2.6	2.9	4.3	2.1	1.5	-1.8	-1.3
Cocaine response before conditioning	0.5	0.6	1.2	1.1	0.2	-0.5	-1.0
Saline control response	0.1	0.2	0.4	0.6	-0.2	-0.2	-0.5
Bone: connectivity density	3.2	5.0	6.5	2.2	2.0	-2.2	-2.5
Bone: cortical apparent density	5.1	6.7	7.8	2.8	2.8	-2.7	-2.0
Bone: cortical area	0.1	0.2	0.3	0.5	0.3	-0.4	-0.2
Bone: cortical porosity	0.3	0.4	0.8	0.9	0.3	-0.4	-0.6
Bone: cortical porosity	0.4	0.4	1.0	1.0	0.2	-0.4	-0.7
Bone: cortical thickness	1.0	1.7	2.7	1.7	1.1	-1.2	-1.2
Bone: cortical thickness	4.2	4.8	6.3	2.5	1.9	-2.0	-2.3
Bone: cortical tissue density	5.1	6.7	7.8	2.8	2.8	-2.7	-2.0
Condit. Reinf. active minus inactive responses	0.6	0.7	1.0	0.7	1.0	-0.7	-0.9
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.5	0.9	0.9	-0.8	-1.2
Condit. Reinf. active responses	0.6	0.8	0.9	0.9	0.9	-0.7	-0.9
Condit. Reinf. inactive responses	0.2	0.2	0.6	0.8	0.1	-0.2	-0.5
Incentive salience index mean	1.6	2.0	2.7	1.3	1.6	-1.3	-1.4
Condit. Reinf. lever presses	1.1	1.5	2.1	1.2	1.4	-1.2	-1.1
Condit. Reinf. active minus inactive responses	0.5	0.7	0.8	0.8	0.9	-0.8	-0.8
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.7	0.5	0.8	-0.6	-0.5
Condit. Reinf. active responses	1.1	1.6	1.8	1.2	1.3	-1.2	-1.3
Condit. Reinf. inactive responses	2.3	2.8	2.9	1.7	1.7	-1.6	-1.7
Condit. Reinf. lever presses	0.0	0.0	0.0	0.2	0.2	-0.2	-0.2
Condit. Reinf. lever reinforcers received	1.1	1.6	2.0	1.2	1.4	-1.2	-1.2
Conditioned reinforcement - actives	1.1	1.1	1.5	1.2	0.6	-1.2	-1.0
Conditioned reinforcement - inactives	1.3	1.4	2.1	1.2	1.5	-1.0	-1.1
Conditioned locomotion	1.1	1.3	1.5	1.2	0.9	-1.1	-1.2
Patch foraging indifference point 0 sec	2.2	3.6	5.0	1.5	2.2	-2.1	-1.6
Patch foraging indifference point AUC	0.2	0.2	0.7	-0.2	0.1	-0.4	0.9
Delay disc. indifference point, 0s delay	1.2	1.3	1.6	1.2	1.3	-1.2	-1.0
Delay disc. indifference point, 16s delay	0.6	0.7	0.8	0.9	0.7	-0.9	-0.7
Delay disc. indifference point, 2s delay	2.2	2.5	3.0	1.7	1.4	-1.7	-1.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.3	0.1	-0.3	-0.3
Delay disc. indifference point, 4s delay	0.6	0.6	1.1	0.8	0.8	-1.1	-0.4
Delay disc. indifference point, 8s delay	0.8	0.8	1.7	0.8	0.5	-0.8	-1.3
Indifference point function ln k	0.1	0.1	0.4	0.1	0.1	-0.0	-0.7
Indifference point function log k	0.1	0.1	0.4	0.1	0.1	-0.0	-0.7
Patch foraging total patch changes 0 sec	1.7	2.7	3.9	1.2	2.0	-1.9	-1.3
Patch foraging total patch changes 12 sec	5.3	6.9	8.5	2.5	2.9	-2.9	-2.1
Patch foraging total patch changes 18 sec	0.7	0.9	1.8	0.8	1.1	-1.3	-0.3
Patch foraging total patch changes 24 sec	1.9	2.3	2.7	1.6	1.6	-1.6	-1.1
Patch foraging total patch changes 6 sec	2.3	3.4	5.3	1.5	2.3	-2.2	-1.1
Patch foraging time to switch 0 sec	0.0	0.1	0.1	0.2	0.2	-0.1	-0.4
Patch foraging water rate 0 sec	0.0	0.0	0.1	-0.1	0.3	-0.0	-0.0
Patch foraging water rate 12 sec	0.4	0.6	0.8	-0.7	-0.6	0.8	0.9
Patch foraging water rate 18 sec	0.6	0.7	1.7	0.8	0.6	-0.5	-1.3
Patch foraging water rate 24 sec	0.4	0.5	1.2	0.6	0.6	-0.4	-1.1
Patch foraging water rate 6 sec	1.1	1.6	2.7	1.1	1.6	-1.1	-1.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	0.0	0.1	0.0	0.5
Distance traveled before self-admin	0.2	0.2	0.5	-0.5	-0.2	0.4	0.7
Distance traveled after self-admin	1.5	1.7	2.0	-1.4	-1.3	1.3	1.1
Extensor digitorum longus weight	9.1	36.0	40.4	-5.8	-6.4	6.1	5.7
Bone: elastic displacement	0.0	0.0	0.1	0.1	-0.1	0.0	-0.3
Bone: elastic work	0.0	0.0	0.0	0.0	-0.1	-0.0	0.0
Bone: endosteal estimation	1.6	3.5	4.7	-2.2	-1.7	1.7	1.9
Bone: endosteal perimeter	1.5	3.2	4.3	-2.0	-1.6	1.5	2.1
Epididymis fat weight	0.2	0.5	0.7	-0.8	-0.7	0.8	0.6
Delta time in closed arm before/after self-admin	3.8	3.7	4.8	-1.9	-2.1	2.2	1.4
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.2	0.0	0.0	0.1
Diff in mean of infusions in LGA sessions	0.4	0.4	0.8	-0.5	-0.7	0.9	-0.0
Delay discount exponential model param	0.5	0.5	0.7	-0.7	-0.4	0.7	0.9
Extinction: sum of active levers before priming	0.7	0.7	1.0	-0.9	-1.0	0.9	0.4
Active lever presses in extinction session 6	1.1	1.0	2.8	0.5	1.7	-0.9	-0.4
Bone: final force	1.0	1.6	2.1	1.4	1.1	-1.3	-1.2
Bone: final moment	0.8	1.3	1.7	1.3	0.9	-1.1	-1.1
Food consumed during 24 hour testing period	0.9	1.1	1.5	-1.1	-0.9	0.9	1.2
Glucose	0.5	0.7	1.1	1.0	0.9	-1.0	-0.2
Heart weight	2.7	3.8	4.7	-2.2	-1.9	2.2	1.6
Delay discount hyperbolic model param	0.7	0.7	1.0	-0.9	-0.6	0.9	1.0
Intermittent access intake day 1-15 change	0.2	0.2	0.6	0.4	0.0	-0.2	-0.8
Intermittent access intake escalation	0.1	0.1	0.3	0.2	0.1	-0.2	-0.6
Intermittent access intake escalation 2	0.1	0.1	0.1	-0.3	-0.4	0.3	0.1
Intermitt. access day 1 inactive lever presses	1.1	1.1	2.4	0.9	1.2	-0.2	-1.5
Intermitt. access day 15 inactive lever presses	3.0	3.3	4.9	1.8	2.2	-1.4	-1.8
Intermitt. access escalation Index	1.4	1.2	3.5	-0.8	-1.9	0.5	0.6
Intermittent access day 1 total infusions	0.1	0.2	0.4	0.4	0.6	-0.4	-0.0
Intermittent access day 15 total infusions	0.3	0.3	0.3	0.5	0.6	-0.5	-0.6
Intermittent access terminal intake (last 3 days)	0.3	0.4	0.5	0.6	0.7	-0.6	-0.5
Intermittent access total infusions	0.0	0.1	0.2	0.1	0.4	-0.2	0.0
Intermittent access day 1 locomotion	0.5	0.5	1.0	0.6	1.0	-0.7	-0.4
Intermittent access day 15 total locomotion	0.6	0.7	1.0	0.8	0.7	-0.7	-1.0
Intermittent access total locomotion	0.9	1.0	1.6	0.9	1.3	-0.8	-0.9
Intermittent access standard deviation	0.4	0.5	1.1	0.4	1.1	-0.3	-0.7
Left kidney weight	1.9	5.4	6.8	-2.6	-2.1	2.4	2.2
Right kidney weight	0.4	1.1	1.4	-1.2	-1.0	1.1	0.8
Cocaine induced anxiety	1.6	1.8	2.5	-1.6	-1.4	1.4	1.0
Post-drug Anxiety	0.0	0.0	0.0	-0.2	-0.2	-0.0	0.1
Baseline Anxiety	2.4	2.5	3.4	1.8	1.3	-1.9	-1.3
Tail length	0.7	2.1	3.2	-1.8	-0.8	1.2	1.8
Length with tail	3.9	14.4	18.1	-4.3	-3.1	3.8	3.9
Length without tail	4.5	9.9	11.4	-3.3	-2.9	3.4	3.0
Times rat made contact with spout	0.9	1.0	1.3	1.1	0.9	-0.9	-1.1
Lifetime Intake	0.0	0.0	0.2	0.1	0.4	-0.1	-0.0
Liver weight, left	0.1	0.2	0.3	-0.3	-0.3	0.4	0.5
Liver weight, right	0.1	0.2	0.5	0.2	0.7	-0.4	-0.1
Locomotor activity	0.6	0.9	1.2	1.0	0.8	-0.9	-1.1
Locomotor testing distance	2.8	4.7	6.4	2.3	1.7	-2.1	-2.5
Locomotor testing rearing	6.7	10.3	11.5	3.0	3.4	-3.4	-3.1
Locomotion in novel chamber	5.3	6.6	9.8	2.5	3.0	-3.1	-1.1
Locomotion in novel chamber post-restriction	0.9	1.0	1.4	0.9	1.1	-1.2	-0.8
Fecal boli incidents, locomotor time 1	0.2	0.3	0.6	-0.5	-0.1	0.5	0.8
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	-0.0	-0.5	-0.2
Time >=10cm from walls, locomotor time 1	0.7	0.7	0.9	0.9	0.8	-0.9	-0.7
Bouts of movement, locomotor time 1	0.6	0.6	1.1	-0.7	-1.0	0.9	0.1
Total resting periods, locomotor time 1	0.9	1.0	1.8	-0.9	-1.3	1.1	0.3
Rest time, locomotor task time 1	0.0	0.0	0.2	0.0	0.0	-0.1	-0.4
Distance moved, locomotor task time 1	0.2	0.2	0.3	0.5	0.5	-0.5	-0.1
Vertical activity count, locomotor time 1	0.0	0.0	0.2	-0.1	-0.0	-0.0	0.4
Time >=10cm from walls, locomotor time 2	1.8	1.9	3.1	1.5	1.4	-1.8	-0.5
Bouts of movement, locomotor time 2	0.2	0.2	0.6	0.2	0.1	-0.0	-0.8
Total resting periods, locomotor time 2	0.1	0.1	0.4	0.0	-0.1	0.2	-0.7
Rest time, locomotor task time 2	0.8	1.0	1.3	-1.2	-0.9	1.1	0.8
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.1	0.4	-0.4	0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	-0.1	0.0	0.0
Light reinforcement 1	2.6	4.7	6.0	1.9	2.1	-2.2	-2.5
Light reinforcement 2	0.8	1.1	1.4	1.0	1.0	-0.9	-1.2
Bone: marrow area	1.5	3.3	4.5	-2.1	-1.6	1.6	1.9
Bone: maximum diameter	0.0	0.0	0.1	0.1	0.2	-0.3	0.2
Bone: maximum force	0.0	0.0	0.1	0.3	0.1	-0.3	-0.2
Bone: maximum moment	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1
Mean time between licks in bursts	1.2	1.7	2.0	-1.4	-1.1	1.3	1.4
Mean num. licks in bursts	0.0	0.0	0.1	0.1	0.2	-0.1	-0.1
Cd content in liver	0.3	0.3	0.6	0.3	0.5	-0.5	-0.8
Co content in liver	1.2	1.4	1.6	-1.3	-1.1	1.2	1.2
Cu content in liver	0.5	0.5	1.2	-1.0	-0.0	0.2	1.1
Fe content in liver	1.2	1.5	1.8	-1.3	-1.1	1.1	1.3
K content in liver	0.9	0.9	1.7	0.6	1.3	-1.3	-0.1
Mg content in liver	0.6	0.6	1.1	0.6	1.0	-1.0	-0.0
Mn content in liver	1.5	1.8	3.0	0.9	1.6	-1.7	-0.8
Na content in liver	0.2	0.2	0.4	0.5	0.5	-0.7	-0.1
Rb content in liver	1.8	2.3	3.4	1.2	1.8	-1.7	-1.1
Se content in liver	3.1	3.8	5.8	1.8	2.4	-2.2	-1.2
Sr content in liver	0.1	0.1	0.3	-0.4	0.2	0.0	0.6
Zn content in liver	2.0	2.2	2.7	1.4	1.6	-1.5	-1.3
Bone: minimum diameter	0.3	0.6	0.8	-0.9	-0.6	0.4	0.9
Time in familiar zone, hab. session 1	0.4	0.4	0.5	0.7	0.6	-0.4	-0.6
Time in novel zone, hab. session 1	0.9	0.8	1.3	0.8	0.8	-0.9	-1.1
Total zone transitions, hab. session 1	2.1	2.9	3.4	-1.8	-1.6	1.7	1.7
Total locomotion distance, hab. session 1	0.0	0.1	0.1	-0.2	-0.3	0.4	0.0
Locomotion velocity, hab. session 1	0.6	0.9	1.0	-1.0	-1.0	1.0	0.8
Time in familiar zone, hab. session 2	0.5	0.6	0.7	0.7	0.8	-0.7	-0.7
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.2	0.3	-0.2	-0.4
Total zone transitions, hab. session 2	0.4	0.5	0.9	-0.9	-0.6	0.7	0.7
Total locomotion distance, hab. session 2	0.1	0.2	0.3	-0.4	-0.4	0.5	-0.1
Locomotion velocity, hab. session 2	0.3	0.4	0.6	-0.6	-0.7	0.8	0.3
Novel to familiar place preference ratio	1.6	1.7	2.0	-1.2	-1.4	1.1	1.4
Novelty place preference	1.2	1.2	1.8	-0.9	-1.4	1.0	1.1
Time in novel zone, NPP test	0.4	0.4	0.9	-0.4	-0.9	0.6	0.6
Total zone transitions, NPP test	0.2	0.3	0.5	-0.7	-0.3	0.4	0.7
Total locomotion distance, NPP test	0.0	0.1	0.1	0.1	0.2	-0.2	-0.3
Locomotion velocity, NPP test	0.1	0.2	0.4	-0.6	-0.4	0.4	0.4
Intraocular pressure	1.7	2.4	3.6	-1.4	-1.9	1.6	1.2
Delta distance traveled before/after self-admin	1.1	1.2	2.0	-1.1	-1.4	1.1	0.6
Delta ambulatory time before/after self-admin	0.5	0.5	1.3	-0.6	-1.1	0.7	-0.2
Parametrial fat weight	0.8	1.6	2.8	1.0	1.2	-0.9	-1.7
Pavlov. Cond. lever latency	2.8	3.6	4.0	-2.0	-2.0	1.7	1.9
Pavlov. Cond. magazine entry latency	9.8	12.7	14.1	3.8	3.5	-3.4	-3.6
Pavlov. Cond. change in total contacts	8.0	8.5	9.2	3.0	3.0	-2.7	-2.9
Pavlov. Cond. index score	8.4	10.6	11.6	3.4	3.3	-3.0	-3.3
Pavlov. Cond. latency score	6.4	8.1	9.1	3.0	2.9	-2.6	-2.8
Pavlov. Cond. lever contacts	2.3	2.6	3.2	1.8	1.6	-1.4	-1.7
Pavlov. Cond. magazine entry number	12.5	15.6	17.1	-4.1	-4.0	3.8	3.9
Pavlov. Cond. intertrial magazine entries	1.4	1.7	1.9	-1.4	-1.3	1.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	9.4	11.7	13.0	3.6	3.4	-3.2	-3.4
Pavlov. Cond. response bias	9.3	11.3	12.5	3.5	3.4	-3.2	-3.4
Pavlov. Cond. lever latency	0.1	0.2	0.3	-0.5	-0.4	0.4	0.5
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	-0.2	-0.5	0.3	0.5
Pavlov. Cond. change in total contacts	0.6	0.8	1.2	0.8	1.0	-1.1	-0.6
Pavlov. Cond. index score	0.1	0.1	0.2	0.5	0.3	-0.3	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	0.3	0.1	-0.2	-0.1
Pavlov. Cond. lever contacts	0.6	0.8	1.1	1.0	0.8	-0.8	-0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.3	-0.0	0.1	0.2
Pavlov. Cond. intertrial magazine entries	1.7	2.2	2.6	-1.4	-1.6	1.6	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.3	0.1	-0.2	-0.1
Pavlov. Cond. response bias	0.8	1.0	1.3	1.1	1.0	-1.0	-0.9
Time in closed arm before self-admin	1.3	1.5	1.8	1.2	1.1	-1.3	-1.3
Time in closed arm after self-admin	0.6	0.6	0.9	-0.8	-1.0	0.7	0.6
Time in open arm before self-admin	2.6	2.8	3.8	-1.9	-1.3	1.4	1.9
Time in open arm after self-admin	0.6	0.6	1.0	-0.8	-0.5	0.8	1.0
Bone: periosteal estimation	0.1	0.3	0.4	-0.6	-0.4	0.3	0.7
Bone: periosteal perimeter	0.7	1.2	1.4	-1.1	-1.1	0.9	1.2
Bone: post-yield work	1.0	1.4	1.9	-1.2	-1.4	1.3	0.7
Progressive ratio test 1 active lever presses	1.3	1.3	2.0	1.2	1.1	-1.4	-0.8
Progressive ratio test 1 breakpoint	1.2	1.2	1.7	1.2	1.0	-1.3	-0.9
Progressive ratio test 1 inactive lever presses	1.2	1.3	2.0	1.0	1.3	-0.7	-1.4
Progressive ratio test 2 active lever presses	1.2	1.3	1.9	1.1	1.3	-1.4	-0.7
Progressive ratio test 2 breakpoint	0.9	1.0	1.4	1.1	1.1	-1.2	-0.7
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.6	0.2	0.8	-0.2	0.1
Incentive Sensitization - Responses	1.0	1.0	1.5	1.1	1.2	-1.1	-0.5
Incentive Sensitization - Breakpoint	1.0	1.0	1.5	1.0	1.2	-1.1	-0.4
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.4	0.7	1.2	-0.6	-0.7
Progressive ratio	0.2	0.3	0.5	0.0	0.6	-0.7	0.4
Food seeking constrained by brief footshock	0.3	0.4	0.5	0.5	0.7	-0.7	-0.5
Seeking ratio, punishment vs. effort	0.2	0.2	0.6	0.5	-0.2	0.1	-0.8
Retroperitoneal fat weight	0.0	0.1	0.3	-0.5	-0.0	0.2	-0.0
Reaction time number correct	1.1	1.6	2.8	-1.1	-1.1	1.1	1.7
Reaction time mean minus median	0.3	0.3	0.9	-0.3	-0.9	0.7	-0.1
Reaction time mean minus median AUC	0.2	0.3	0.6	0.6	-0.3	-0.0	-0.8
Reaction time num false alarms	0.8	1.0	1.1	1.1	1.0	-1.0	-1.0
Reaction time num false alarms AUC	0.5	0.7	0.8	0.9	0.7	-0.7	-0.9
Reaction time trials correct on left	1.1	1.6	2.8	-1.1	-1.1	1.1	1.7
Reaction time trials on left	1.1	1.5	2.7	-1.0	-1.1	1.1	1.7
Reaction time mean	0.0	0.0	0.1	0.1	-0.3	0.2	-0.3
Reaction time mean AUC	0.0	0.1	0.1	0.0	-0.3	0.1	-0.3
Median of all reaction times	0.2	0.3	0.4	0.6	0.4	-0.4	-0.6
Reaction time omissions	0.7	1.0	1.4	1.0	0.8	-1.1	-1.2
Reaction time false alarm rate	1.3	1.7	2.7	1.3	1.1	-1.1	-1.7
Reaction time premature initiation rate	0.3	0.4	0.9	0.6	0.3	-0.5	-0.9
Reaction time premature initiations	0.1	0.1	0.2	-0.2	-0.5	0.4	0.2
Std. dev. reaction times	0.1	0.1	0.4	0.1	-0.6	0.3	-0.3
Reaction time trials completed	1.1	1.5	2.7	-1.0	-1.1	1.1	1.7
Reaction time trials AUC	0.9	1.4	2.5	-0.9	-1.0	1.0	1.6
Run reversals in cocaine runway, females	2.5	2.4	2.9	-1.6	-1.6	1.7	1.3
Run reversals in cocaine runway, males	0.5	0.5	0.9	0.7	0.9	-0.7	-0.4
Latency to leave start box in cocaine runway	3.0	3.3	5.4	-1.8	-1.3	1.6	2.3
Latency to leave start box in cocaine runway, F	3.1	3.4	5.8	-1.7	-1.5	1.6	2.4
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.5	0.6	-0.0	0.4
Std. dev. time between licks in bursts	0.2	0.2	0.3	-0.5	-0.5	0.5	0.4
Total sessions with >9 infusions	1.0	1.1	1.4	1.0	1.2	-0.9	-1.2
Short access day 1 total inactive lever presses	1.5	1.6	2.4	1.3	1.4	-0.7	-1.5
Short access day 10 total inactive lever presses	0.6	0.7	1.8	-0.8	-0.6	1.3	0.0
Short access day 1 total infusions	0.4	0.4	1.2	0.4	1.1	-0.2	-0.3
Short access day 10 total infusions	0.2	0.3	0.4	0.5	0.6	-0.6	-0.2
Short access total infusions	0.1	0.1	0.2	0.0	0.5	0.0	0.1
Short access day 1 locomotion	3.2	3.4	6.1	1.6	2.5	-1.5	-1.6
Short access day 10 total locomotion	2.3	2.5	3.4	1.5	1.8	-1.6	-1.4
Short access total locomotion	0.7	0.7	1.3	0.7	1.1	-0.6	-0.8
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.2	-0.3	-0.2	-0.2
Compulsive drug intake	0.1	0.1	0.1	-0.2	-0.4	0.2	-0.0
One hour access (shock baseline)	0.1	0.1	0.2	0.4	0.3	-0.4	-0.4
Social response proportion	0.0	0.0	0.1	0.1	-0.3	-0.1	-0.2
Social responses	0.2	0.3	0.6	0.3	0.5	-0.8	-0.4
Social time	0.0	0.0	0.1	-0.1	-0.4	-0.1	-0.1
Soleus weight	0.3	0.9	1.9	1.2	0.4	-0.6	-1.4
Bone: stiffness	0.0	0.1	0.1	0.3	0.2	-0.4	-0.1
Tibialis anterior weight	1.5	5.1	6.1	-2.1	-2.5	2.3	2.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.4	0.1	-0.4	-0.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	0.3	0.4	-0.5	-0.2
Time to tail flick, test, before self-admin	1.0	1.0	2.2	-0.8	-1.5	1.0	0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.3	0.8	-0.3	-0.0
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.4	0.6	0.7	-0.5	-0.6
Delta time to tail flick, test, before/after SA	2.6	2.4	4.9	1.4	2.2	-1.5	-0.7
Tibia length	1.0	2.8	3.5	-1.5	-1.9	1.8	1.5
Ambulatory time before self-admin	0.4	0.4	0.9	-0.7	-0.3	0.4	1.0
Ambulatory time after self-admin	2.6	2.8	3.5	-1.9	-1.7	1.8	1.3
Bone: tissue strength	0.6	0.6	0.9	-0.6	-1.0	0.9	0.5
Total heroin consumption	0.7	0.9	1.9	0.6	1.4	-1.0	-0.4
Bone: trabecular number	5.2	8.1	8.5	2.9	2.7	-2.9	-2.9
Bone: trabecular spacing	1.0	1.3	1.5	-1.1	-1.1	1.1	1.2
Bone: trabecular thickness	0.0	0.0	0.1	0.2	-0.1	0.1	-0.4
Bone: trabecular tissue density	0.0	0.0	0.0	0.1	0.1	0.0	-0.1
Water consumed over 24 hours	0.1	0.1	0.2	-0.0	-0.4	0.4	-0.1
Number of responses in last shaping day	0.2	0.2	0.7	-0.1	0.9	0.2	0.3