Hub : Genes

Plpp3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	Plpp3	0.19	0.17	2.8e-03	0.09	0.06	0.07	0.08	4.9e-03	1.4e-02	1.1e-02	7.3e-03
2	IL	mRNA stability	Plpp3	0.29	0.2	6.1e-05	0.18	0.18	0.18	0.18	3.8e-05	4.8e-05	3.3e-05	4.0e-05
3	Liver	gene expression	Plpp3	0.47	0.16	0.0e+00	0.42	0.42	0.42	0.42	1.2e-49	2.7e-50	1.8e-50	3.6e-50
4	NAcc	gene expression	Plpp3	0.09	0.1	7.6e-09	0.06	0.06	0.05	0.06	3.3e-07	2.4e-07	9.2e-07	1.8e-07
5	Brain	gene expression	Plpp3	0.41	0.37	1.3e-11	0.12	0.12	0.12	0.12	1.4e-11	1.3e-11	1.9e-11	1.6e-11
6	pVTA	mRNA stability	Plpp3	0.11	0.1	2.7e-04	0.07	0.08	0.08	0.08	3.9e-04	2.1e-04	3.5e-04	3.5e-04
7	PL	mRNA stability	Plpp3	0.06	0.05	8.5e-08	0.04	0.06	0.05	0.04	9.4e-06	7.5e-07	5.4e-06	9.0e-06
8	Adipose	mRNA stability	Plpp3	0.05	0.04	6.8e-05	0.02	0.02	0.02	0.01	4.2e-03	3.5e-03	5.8e-03	8.4e-03
9	Adipose	gene expression	Plpp3	0.14	0.12	9.2e-07	0.04	0.03	0.03	0.03	8.2e-05	2.0e-04	1.4e-04	1.6e-04
10	PL	gene expression	Plpp3	0.09	0.06	6.9e-11	0.07	0.07	0.07	0.07	2.1e-08	2.5e-08	1.3e-08	1.4e-08
11	pVTA	gene expression	Plpp3	0.05	0.03	1.4e-03	0.04	0.02	0.02	0.03	1.1e-02	3.6e-02	6.4e-02	2.6e-02
12	NAcc	mRNA stability	Plpp3	0.08	0.08	2.1e-07	0.05	0.04	0.03	0.05	1.2e-06	5.8e-05	8.8e-05	1.5e-06
13	Liver	mRNA stability	Plpp3	0.28	0.17	0.0e+00	0.17	0.16	0.16	0.16	4.3e-18	4.9e-17	2.8e-17	7.1e-17
14	Brain	mRNA stability	Plpp3	0.72	0.13	2.0e-13	0.13	0.16	0.15	0.14	8.1e-12	1.1e-14	7.1e-14	1.4e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14
Bone: apparent density	0.4	0.7	0.8	-0.8	-0.9	-0.9	0.9	0.8	0.8	0.8	0.8	0.9	-0.8	-0.7	-0.8	-0.7	0.7
Area under the delay curve	0.7	0.8	1.0	0.9	0.9	0.9	-0.9	-0.9	-0.9	-0.9	-0.9	-0.9	1.0	0.8	0.8	1.0	-0.8
BMI with tail	0.3	1.0	1.4	-1.1	-1.0	-1.1	0.9	1.1	0.9	0.9	0.9	0.9	-0.9	-0.9	-0.9	-0.9	1.2
BMI without tail	0.1	0.3	0.6	0.6	0.4	0.2	-0.6	-0.2	-0.5	-0.6	-0.5	-0.5	0.7	0.8	0.7	0.5	0.3
Body weight	0.1	0.6	0.8	-0.9	-0.7	-0.8	0.8	0.7	0.8	0.8	0.8	0.8	-0.7	-0.8	-0.7	-0.6	0.5
Weight adjusted by age	0.1	0.2	0.5	0.5	0.1	0.4	-0.3	-0.4	-0.2	-0.2	-0.3	-0.5	0.4	0.5	0.3	0.5	-0.7
Bone surface	0.0	0.0	0.3	0.2	-0.5	-0.2	0.2	0.1	0.2	0.2	0.2	-0.0	-0.1	-0.1	-0.2	-0.2	-0.2
Bone volume	0.2	0.3	0.6	-0.3	-0.8	-0.6	0.6	0.5	0.6	0.6	0.6	0.5	-0.5	-0.5	-0.6	-0.6	0.3
Breakpoint value in progressive ratio session	0.0	0.0	0.3	0.1	0.1	0.2	-0.1	-0.2	-0.1	-0.1	-0.1	-0.1	0.1	0.1	0.1	0.3	-0.6
Number of licking bursts	0.0	0.0	0.1	0.3	0.1	0.2	-0.1	-0.2	-0.2	-0.2	-0.2	0.1	0.2	0.1	0.2	0.2	-0.3
Context. condit. distance diff. score	2.5	3.0	3.5	-1.8	-1.8	-1.8	1.7	1.8	1.7	1.7	1.7	1.9	-1.7	-1.8	-1.6	-1.7	1.6
Locomotion velocity, session 1	0.6	0.7	1.4	0.7	0.5	0.9	-0.7	-1.0	-0.8	-0.8	-0.8	-0.7	0.8	0.7	0.9	0.8	-1.2
Locomotion distance, session 1	0.1	0.2	0.3	-0.5	-0.4	-0.5	0.4	0.4	0.4	0.4	0.4	0.5	-0.4	-0.5	-0.3	-0.4	0.4
Locomotion velocity, session 2	0.1	0.1	0.3	0.3	0.0	0.6	-0.3	-0.5	-0.4	-0.4	-0.4	-0.2	0.3	0.3	0.3	0.3	-0.5
Locomotion distance, session 2	0.0	0.0	0.1	-0.1	-0.4	-0.3	0.2	0.2	0.2	0.2	0.2	0.0	-0.1	-0.2	-0.1	-0.2	0.3
Locomotion velocity, session 3	1.9	2.2	2.8	-1.5	-1.3	-1.5	1.4	1.5	1.5	1.5	1.5	1.2	-1.6	-1.6	-1.5	-1.7	1.5
Locomotion distance, session 3	1.2	1.4	1.9	-1.4	-0.9	-1.2	1.1	1.2	1.1	1.1	1.2	1.0	-1.2	-1.2	-1.1	-1.2	1.3
Stereotopy head waving bouts, day 3	0.8	1.0	1.7	-1.0	-1.3	-0.8	1.1	0.8	1.0	1.0	1.0	1.2	-1.0	-0.9	-1.0	-1.0	0.5
Stereotopy head waving duration, day 3	0.0	0.1	0.3	-0.1	-0.6	-0.0	0.4	0.1	0.2	0.2	0.2	0.4	-0.2	-0.1	-0.1	-0.2	-0.2
Locomotion velocity, session 7	0.4	0.4	0.6	-0.8	-0.6	-0.8	0.6	0.7	0.7	0.7	0.7	0.5	-0.6	-0.7	-0.7	-0.6	0.7
Locomotion distance, session 7	0.2	0.2	0.8	-0.5	-0.2	-0.7	0.3	0.6	0.4	0.4	0.4	0.3	-0.4	-0.5	-0.4	-0.3	0.9
Stereotopy head waving bouts, day 7	0.3	0.3	0.7	0.4	0.4	0.8	-0.4	-0.7	-0.5	-0.5	-0.5	-0.4	0.5	0.5	0.5	0.4	-0.9
Stereotopy head waving duration, day 7	0.5	0.6	1.1	0.7	0.6	0.9	-0.6	-0.9	-0.7	-0.7	-0.7	-0.7	0.8	0.7	0.7	0.7	-1.0
Locomotion velocity, session 8	0.0	0.1	0.2	-0.2	-0.5	-0.2	0.2	0.1	0.2	0.2	0.2	0.2	-0.2	-0.2	-0.1	-0.3	-0.1
Locomotion distance, session 8	2.9	4.3	4.8	-2.2	-2.2	-2.2	2.1	2.1	2.0	2.0	2.0	2.0	-2.0	-2.2	-2.0	-2.0	1.9
Degree of sensitization distance	0.1	0.1	0.2	0.4	0.2	0.2	-0.3	-0.2	-0.3	-0.3	-0.3	-0.1	0.4	0.3	0.3	0.4	-0.2
Degree of sensitization stereotypy	0.4	0.4	1.0	0.6	0.7	0.9	-0.6	-0.8	-0.6	-0.6	-0.6	-0.7	0.6	0.6	0.5	0.5	-1.0
Conditioned locomotion	0.0	0.0	0.2	0.2	0.2	-0.0	-0.3	0.0	-0.2	-0.2	-0.2	-0.4	0.2	0.3	0.2	0.2	0.3
Cocaine response after cond. corrected	2.3	2.6	3.9	-1.5	-1.4	-2.0	1.5	1.8	1.6	1.6	1.6	1.4	-1.5	-1.5	-1.6	-1.5	1.7
Cocaine response after cond. not corrected	1.7	1.9	2.8	-1.2	-1.2	-1.7	1.2	1.5	1.4	1.4	1.4	1.0	-1.3	-1.3	-1.4	-1.4	1.4
Cocaine response before conditioning	1.6	2.0	2.5	1.6	1.5	1.5	-1.4	-1.4	-1.3	-1.3	-1.3	-1.6	1.3	1.4	1.3	1.3	-1.3
Saline control response	0.1	0.1	0.2	-0.4	-0.3	-0.4	0.3	0.4	0.3	0.4	0.4	0.1	-0.4	-0.3	-0.3	-0.3	0.5
Bone: connectivity density	0.0	0.1	0.2	-0.3	-0.4	-0.2	0.3	0.2	0.2	0.2	0.2	0.4	-0.3	-0.2	-0.2	-0.1	0.2
Bone: cortical apparent density	1.6	2.1	2.7	1.5	1.6	1.4	-1.3	-1.4	-1.4	-1.4	-1.4	-1.3	1.4	1.5	1.4	1.4	-1.6
Bone: cortical area	0.1	0.1	0.1	-0.2	-0.2	-0.3	0.4	0.2	0.4	0.3	0.3	0.2	-0.2	-0.3	-0.3	-0.4	-0.2
Bone: cortical porosity	1.5	1.6	2.3	-1.3	-1.5	-1.3	1.3	1.3	1.3	1.3	1.3	1.3	-1.2	-1.2	-1.2	-1.3	1.2
Bone: cortical porosity	0.2	0.3	0.7	-0.6	-0.8	-0.5	0.6	0.5	0.5	0.5	0.5	0.6	-0.4	-0.4	-0.4	-0.5	0.3
Bone: cortical thickness	0.5	0.8	1.0	-0.8	-0.5	-1.0	0.9	0.9	1.0	1.0	1.0	0.8	-0.9	-0.9	-1.0	-1.0	0.5
Bone: cortical thickness	0.9	1.0	1.4	-1.1	-0.8	-1.0	1.0	1.0	1.1	1.1	1.1	0.7	-1.1	-1.2	-1.1	-1.1	0.7
Bone: cortical tissue density	1.7	2.2	2.8	1.6	1.7	1.5	-1.4	-1.5	-1.4	-1.4	-1.4	-1.4	1.5	1.5	1.5	1.5	-1.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	-0.7	-0.6	-0.0	0.6	0.1	0.4	0.4	0.4	0.6	-0.4	-0.5	-0.4	-0.5	-0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.4	0.2	0.2	0.2	0.2	0.4	-0.2	-0.3	-0.1	-0.2	0.1
Condit. Reinf. active responses	0.1	0.1	0.3	-0.4	-0.6	0.0	0.4	0.1	0.3	0.3	0.3	0.4	-0.3	-0.3	-0.3	-0.5	-0.1
Condit. Reinf. inactive responses	0.2	0.2	0.3	0.5	0.4	0.4	-0.6	-0.4	-0.4	-0.4	-0.4	-0.6	0.4	0.6	0.5	0.4	-0.2
Incentive salience index mean	0.4	0.5	1.0	-0.9	-1.0	-0.3	0.8	0.4	0.7	0.7	0.7	0.8	-0.7	-0.8	-0.7	-0.8	0.1
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.6	-0.6	-0.2	0.5	0.2	0.4	0.4	0.4	0.5	-0.4	-0.5	-0.4	-0.5	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.5	0.7	0.5	-0.4	-0.5	-0.5	-0.5	-0.5	-0.5	0.4	0.4	0.4	0.4	-0.6
Condit. Reinf. active-inactive response ratio	0.7	0.8	0.9	0.8	1.0	0.9	-0.8	-0.9	-0.9	-0.9	-0.9	-0.8	0.9	0.9	0.9	0.9	-0.9
Condit. Reinf. active responses	0.0	0.0	0.0	0.0	0.2	0.1	-0.0	-0.1	0.0	0.0	0.0	-0.0	-0.1	-0.1	-0.1	-0.0	-0.1
Condit. Reinf. inactive responses	0.6	0.7	0.9	-0.8	-0.7	-0.8	0.8	0.8	0.9	0.9	0.9	0.8	-0.9	-0.9	-0.9	-0.9	0.8
Condit. Reinf. lever presses	6.6	8.9	10.4	3.0	3.2	3.1	-3.1	-3.1	-2.9	-2.9	-2.9	-3.0	2.9	2.9	2.9	2.9	-2.9
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	0.4	0.5	0.5	-0.4	-0.5	-0.4	-0.4	-0.4	-0.4	0.3	0.2	0.3	0.3	-0.4
Conditioned reinforcement - actives	0.6	0.6	0.8	-0.7	-0.7	-0.8	0.8	0.8	0.8	0.8	0.8	0.7	-0.8	-0.9	-0.7	-0.9	0.9
Conditioned reinforcement - inactives	0.2	0.2	0.3	-0.4	-0.3	-0.4	0.5	0.4	0.3	0.3	0.4	0.4	-0.4	-0.6	-0.5	-0.3	0.6
Conditioned locomotion	0.8	1.0	1.2	-1.0	-1.0	-1.0	1.0	1.0	0.9	0.9	1.0	1.0	-1.0	-1.1	-1.0	-1.0	1.1
Patch foraging indifference point 0 sec	0.6	1.0	1.3	1.1	1.1	1.0	-1.1	-1.0	-1.1	-1.1	-1.0	-1.1	1.0	1.1	1.0	1.1	-0.6
Patch foraging indifference point AUC	0.9	1.0	1.4	1.1	1.0	0.9	-1.1	-0.9	-1.0	-1.0	-1.0	-1.1	1.1	1.2	1.1	1.0	-0.7
Delay disc. indifference point, 0s delay	0.0	0.1	0.5	0.0	0.2	-0.1	-0.1	0.2	-0.1	-0.1	-0.1	-0.0	0.1	0.1	0.2	-0.0	0.7
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	0.3	0.1	-0.3	-0.1	-0.3	-0.2	-0.2	-0.3	0.2	0.2	-0.1	0.2	0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.1	0.2	0.3	-0.2	-0.3	-0.3	-0.3	-0.3	-0.1	0.3	0.2	0.3	0.3	-0.5
Delay disc. indifference point, 24s delay	3.7	3.5	4.6	1.8	1.9	1.9	-1.8	-2.0	-1.9	-1.9	-1.9	-1.8	1.9	1.7	1.7	2.0	-2.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.5	0.3	0.3	0.1	-0.3	0.1	-0.3	-0.2	-0.2	-0.3	0.2	0.3	0.2	0.0	0.7
Delay disc. indifference point, 8s delay	0.6	0.6	1.0	0.7	0.7	0.8	-0.7	-0.8	-0.8	-0.8	-0.8	-0.7	0.8	0.7	0.8	0.9	-1.0
Indifference point function ln k	0.6	0.8	1.1	-0.9	-1.0	-0.8	1.0	0.8	1.0	1.0	1.0	0.8	-1.0	-1.0	-1.1	-1.0	0.5
Indifference point function log k	0.6	0.8	1.1	-0.9	-1.0	-0.8	1.0	0.8	1.0	1.0	1.0	0.8	-1.0	-1.0	-1.1	-1.0	0.5
Patch foraging total patch changes 0 sec	0.5	0.8	1.0	0.9	1.0	0.9	-1.0	-0.8	-0.9	-0.9	-0.9	-1.0	0.8	0.9	0.9	0.9	-0.5
Patch foraging total patch changes 12 sec	1.7	2.2	2.7	1.6	1.5	1.3	-1.6	-1.4	-1.5	-1.5	-1.5	-1.5	1.5	1.6	1.6	1.5	-1.2
Patch foraging total patch changes 18 sec	0.4	0.6	0.8	0.8	0.6	0.7	-0.7	-0.7	-0.8	-0.8	-0.8	-0.7	0.8	0.8	0.9	0.9	-0.5
Patch foraging total patch changes 24 sec	0.5	0.6	1.0	0.8	1.0	0.6	-0.8	-0.7	-0.7	-0.8	-0.8	-0.7	0.8	0.8	0.8	0.9	-0.8
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.4	0.6	0.4	-0.5	-0.4	-0.5	-0.5	-0.4	-0.2	0.4	0.4	0.4	0.5	-0.2
Patch foraging time to switch 0 sec	1.0	1.5	1.8	1.1	1.1	1.3	-1.3	-1.3	-1.3	-1.3	-1.3	-1.0	1.3	1.2	1.3	1.3	-1.0
Patch foraging water rate 0 sec	1.4	2.3	2.5	-1.5	-1.5	-1.6	1.6	1.5	1.6	1.6	1.6	1.3	-1.5	-1.5	-1.5	-1.5	1.2
Patch foraging water rate 12 sec	2.0	3.0	3.8	-2.0	-1.7	-1.6	2.0	1.6	1.8	1.8	1.8	1.8	-1.8	-1.9	-1.7	-1.7	0.9
Patch foraging water rate 18 sec	0.1	0.2	1.9	0.1	0.2	0.3	0.0	-0.5	-0.1	-0.1	-0.2	-0.0	0.2	-0.1	0.3	0.2	-1.4
Patch foraging water rate 24 sec	1.8	2.6	3.4	-1.8	-1.4	-1.4	1.8	1.4	1.7	1.7	1.7	1.7	-1.7	-1.8	-1.7	-1.6	0.7
Patch foraging water rate 6 sec	0.0	0.0	0.4	-0.0	0.0	-0.1	0.1	-0.1	0.1	0.1	0.1	-0.1	-0.0	-0.1	0.0	-0.1	-0.6
Seeking ratio, delayed vs. immediate footshock	3.7	4.2	5.4	-2.3	-2.3	-2.0	2.3	1.8	2.2	2.2	2.1	2.3	-2.0	-2.3	-1.8	-1.9	0.6
Distance traveled before self-admin	3.4	3.6	4.6	-1.8	-1.8	-2.0	1.8	2.0	1.9	1.9	1.9	1.8	-1.9	-1.8	-1.8	-2.0	2.1
Distance traveled after self-admin	2.7	3.0	3.4	-1.7	-1.8	-1.7	1.7	1.7	1.8	1.8	1.8	1.7	-1.8	-1.7	-1.9	-1.8	1.3
Extensor digitorum longus weight	4.8	19.1	21.9	-4.5	-4.4	-4.7	4.3	4.5	4.4	4.4	4.4	4.3	-4.3	-4.3	-4.3	-4.3	4.0
Bone: elastic displacement	1.4	1.6	2.1	-1.3	-1.4	-1.3	1.2	1.3	1.2	1.2	1.2	1.1	-1.3	-1.3	-1.3	-1.2	1.5
Bone: elastic work	1.5	1.9	2.5	-1.6	-1.5	-1.4	1.5	1.4	1.4	1.4	1.4	1.4	-1.3	-1.3	-1.3	-1.3	1.2
Bone: endosteal estimation	0.1	0.1	0.9	-0.1	-1.0	-0.2	0.4	0.2	0.3	0.3	0.2	0.3	-0.1	-0.3	-0.2	-0.3	-0.1
Bone: endosteal perimeter	0.4	0.9	1.3	1.2	0.5	0.9	-0.9	-1.0	-0.9	-0.9	-0.9	-0.9	1.1	0.9	0.9	0.9	-1.1
Epididymis fat weight	0.2	0.5	0.8	0.6	0.8	0.9	-0.8	-0.8	-0.7	-0.7	-0.7	-0.8	0.6	0.6	0.6	0.6	-0.6
Delta time in closed arm before/after self-admin	5.0	4.9	6.5	-2.0	-2.0	-2.3	2.0	2.4	2.2	2.2	2.2	2.0	-2.2	-2.0	-2.4	-2.3	2.6
Delta time in open arm before/after self-admin	2.6	2.5	2.8	1.7	1.7	1.6	-1.7	-1.5	-1.7	-1.7	-1.6	-1.7	1.6	1.6	1.6	1.6	-1.1
Diff in mean of infusions in LGA sessions	1.3	1.4	1.8	-1.2	-1.2	-1.3	1.2	1.3	1.1	1.1	1.1	1.2	-1.1	-1.2	-1.1	-1.2	1.3
Delay discount exponential model param	0.6	0.7	0.8	-0.8	-0.8	-0.8	0.8	0.8	0.8	0.8	0.8	0.8	-0.9	-0.7	-0.7	-0.9	0.8
Extinction: sum of active levers before priming	1.1	1.1	1.3	-1.0	-1.0	-1.1	1.0	1.1	1.1	1.1	1.1	1.0	-1.1	-1.0	-1.1	-1.1	1.2
Active lever presses in extinction session 6	2.8	2.7	4.9	-1.4	-1.3	-1.8	1.4	1.9	1.6	1.7	1.7	1.4	-1.7	-1.4	-1.8	-1.8	2.2
Bone: final force	0.0	0.1	0.1	-0.3	-0.1	-0.4	0.2	0.3	0.3	0.3	0.3	0.3	-0.2	-0.2	-0.1	-0.2	0.1
Bone: final moment	0.1	0.2	0.4	-0.5	-0.4	-0.6	0.4	0.5	0.5	0.5	0.5	0.5	-0.4	-0.4	-0.3	-0.4	0.3
Food consumed during 24 hour testing period	1.5	1.8	2.1	1.4	1.3	1.4	-1.2	-1.3	-1.4	-1.4	-1.4	-1.1	1.4	1.5	1.4	1.4	-1.3
Glucose	0.0	0.0	0.1	0.0	0.3	-0.1	-0.1	0.0	-0.1	-0.1	-0.1	-0.2	0.1	0.1	-0.0	0.1	0.0
Heart weight	1.0	1.4	2.1	-1.3	-1.0	-1.1	1.2	1.1	1.2	1.2	1.2	1.1	-1.3	-1.4	-1.3	-1.2	0.9
Delay discount hyperbolic model param	0.6	0.6	0.8	-0.8	-0.8	-0.8	0.8	0.8	0.8	0.8	0.8	0.8	-0.9	-0.7	-0.7	-0.9	0.8
Intermittent access intake day 1-15 change	0.7	0.7	0.9	0.7	0.7	0.9	-0.7	-0.9	-0.8	-0.9	-0.9	-0.7	0.8	0.6	0.9	0.9	-0.9
Intermittent access intake escalation	0.6	0.6	0.8	0.7	0.7	0.8	-0.6	-0.8	-0.8	-0.8	-0.8	-0.7	0.8	0.6	0.9	0.9	-0.9
Intermittent access intake escalation 2	1.9	1.9	2.3	1.3	1.3	1.5	-1.3	-1.4	-1.5	-1.5	-1.5	-1.3	1.4	1.2	1.5	1.5	-1.2
Intermitt. access day 1 inactive lever presses	7.2	7.8	8.9	-3.0	-3.0	-2.6	3.0	2.6	2.8	2.8	2.8	3.0	-2.8	-3.0	-2.9	-2.7	1.9
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.4	-0.6	-0.6	-0.5	0.6	0.6	0.5	0.5	0.5	0.6	-0.5	-0.6	-0.5	-0.3	0.6
Intermitt. access escalation Index	1.7	1.5	3.9	1.0	1.0	1.2	-1.1	-1.4	-1.1	-1.1	-1.2	-1.0	1.2	1.1	1.2	1.4	-2.0
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.2	-0.1	-0.3	0.2	0.3	0.3	0.3	0.3	0.2	-0.3	-0.3	-0.2	-0.4	0.4
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.3	0.3	0.3	-0.2	-0.4	-0.4	-0.4	-0.4	-0.3	0.4	0.2	0.4	0.3	-0.4
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.3	0.4	0.4	-0.3	-0.4	-0.4	-0.4	-0.4	-0.3	0.4	0.3	0.5	0.4	-0.3
Intermittent access total infusions	0.0	0.0	0.1	-0.2	-0.1	-0.0	0.2	0.0	0.1	0.1	0.1	0.2	-0.1	-0.3	-0.0	-0.1	-0.1
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.0	-0.0	-0.0	-0.1	-0.1	-0.0	0.1
Intermittent access day 15 total locomotion	0.4	0.4	0.6	0.7	0.8	0.6	-0.7	-0.5	-0.7	-0.7	-0.7	-0.7	0.7	0.6	0.7	0.6	-0.1
Intermittent access total locomotion	0.4	0.4	0.6	0.7	0.8	0.7	-0.7	-0.6	-0.8	-0.7	-0.7	-0.7	0.7	0.6	0.7	0.6	-0.1
Intermittent access standard deviation	0.3	0.3	1.1	-0.5	-0.4	-0.5	0.5	0.6	0.4	0.4	0.4	0.5	-0.5	-0.6	-0.4	-0.5	1.1
Left kidney weight	8.8	24.7	27.5	-5.1	-5.2	-5.1	5.1	5.0	4.9	4.9	4.9	5.1	-4.9	-5.0	-5.0	-4.7	4.5
Right kidney weight	6.0	16.7	19.6	-4.3	-4.4	-4.1	4.2	4.0	4.1	4.1	4.1	4.2	-4.1	-4.2	-4.1	-3.9	3.2
Cocaine induced anxiety	0.2	0.3	0.4	0.5	0.5	0.4	-0.6	-0.5	-0.5	-0.5	-0.5	-0.5	0.6	0.6	0.6	0.4	-0.3
Post-drug Anxiety	0.1	0.1	0.2	0.3	0.3	0.2	-0.3	-0.2	-0.4	-0.4	-0.3	-0.3	0.4	0.4	0.3	0.4	0.1
Baseline Anxiety	1.6	1.7	2.1	-1.3	-1.3	-1.3	1.3	1.4	1.2	1.2	1.2	1.3	-1.3	-1.3	-1.4	-1.0	1.5
Tail length	0.3	0.8	1.0	0.9	0.9	0.8	-0.8	-0.9	-0.8	-0.9	-0.9	-0.7	1.0	0.9	1.0	0.9	-1.0
Length with tail	0.0	0.1	0.5	-0.2	0.1	0.1	0.3	-0.1	0.1	0.1	0.1	0.2	-0.1	-0.2	-0.1	0.0	-0.7
Length without tail	1.1	2.3	3.2	-1.7	-1.3	-1.2	1.7	1.3	1.6	1.6	1.6	1.5	-1.7	-1.8	-1.7	-1.5	0.7
Times rat made contact with spout	0.1	0.2	0.5	-0.2	-0.3	-0.5	0.5	0.4	0.4	0.3	0.4	0.7	-0.3	-0.2	-0.2	-0.2	0.4
Lifetime Intake	0.0	0.0	0.0	-0.0	-0.0	0.0	0.1	-0.1	-0.0	-0.0	-0.0	0.0	0.0	-0.1	0.1	-0.0	-0.1
Liver weight, left	0.1	0.2	0.4	-0.4	-0.5	-0.4	0.5	0.4	0.4	0.4	0.4	0.6	-0.4	-0.4	-0.4	-0.4	0.3
Liver weight, right	2.0	3.3	3.9	-1.8	-2.0	-1.9	1.9	1.8	1.8	1.8	1.8	2.0	-1.8	-1.8	-1.8	-1.8	1.4
Locomotor activity	0.1	0.1	0.2	-0.2	-0.2	-0.1	0.4	0.2	0.3	0.3	0.3	0.4	-0.3	-0.4	-0.3	-0.3	0.0
Locomotor testing distance	0.2	0.3	0.4	-0.5	-0.4	-0.5	0.6	0.6	0.6	0.6	0.6	0.6	-0.6	-0.6	-0.5	-0.5	0.6
Locomotor testing rearing	0.3	0.5	0.6	-0.7	-0.6	-0.6	0.8	0.7	0.7	0.7	0.7	0.6	-0.7	-0.7	-0.7	-0.7	0.6
Locomotion in novel chamber	0.7	0.9	1.3	-0.9	-1.1	-0.9	1.0	1.0	1.0	1.0	1.0	0.9	-1.0	-0.9	-0.8	-1.0	0.9
Locomotion in novel chamber post-restriction	1.6	1.9	2.3	-1.5	-1.4	-1.2	1.4	1.3	1.3	1.3	1.3	1.5	-1.3	-1.5	-1.3	-1.3	1.4
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	-0.5	-0.6	-0.4	0.5	0.4	0.4	0.4	0.4	0.5	-0.5	-0.4	-0.5	-0.4	0.4
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	0.6	0.5	0.5	-0.6	-0.6	-0.5	-0.5	-0.5	-0.6	0.6	0.6	0.7	0.5	-0.8
Time >=10cm from walls, locomotor time 1	0.4	0.5	0.8	-0.9	-0.9	-0.4	0.9	0.3	0.7	0.6	0.6	0.9	-0.5	-0.8	-0.6	-0.3	-0.7
Bouts of movement, locomotor time 1	0.1	0.1	0.4	-0.3	-0.3	-0.2	0.4	0.0	0.2	0.2	0.2	0.3	-0.2	-0.4	-0.2	0.1	-0.6
Total resting periods, locomotor time 1	0.1	0.1	0.4	-0.4	-0.4	-0.2	0.4	0.0	0.3	0.3	0.2	0.4	-0.2	-0.4	-0.3	0.0	-0.7
Rest time, locomotor task time 1	0.3	0.4	0.5	-0.7	-0.6	-0.6	0.7	0.6	0.6	0.6	0.6	0.7	-0.6	-0.7	-0.6	-0.5	0.4
Distance moved, locomotor task time 1	0.5	0.6	0.9	0.9	0.8	0.6	-0.9	-0.7	-0.7	-0.7	-0.7	-0.9	0.7	0.9	0.8	0.5	-0.6
Vertical activity count, locomotor time 1	0.1	0.1	0.3	0.5	0.4	0.1	-0.5	-0.1	-0.3	-0.3	-0.3	-0.5	0.3	0.5	0.4	-0.1	0.5
Time >=10cm from walls, locomotor time 2	1.0	1.1	1.4	-1.2	-1.1	-1.0	1.2	1.0	1.1	1.1	1.1	1.2	-1.0	-1.1	-0.9	-1.0	0.5
Bouts of movement, locomotor time 2	0.2	0.2	0.8	-0.5	-0.4	0.0	0.5	-0.1	0.3	0.3	0.2	0.5	-0.3	-0.6	-0.6	0.2	-0.9
Total resting periods, locomotor time 2	0.1	0.2	1.2	-0.3	-0.1	0.3	0.3	-0.4	-0.0	-0.0	-0.0	0.3	-0.1	-0.3	-0.3	0.5	-1.1
Rest time, locomotor task time 2	0.3	0.4	0.6	0.6	0.5	0.6	-0.6	-0.6	-0.6	-0.6	-0.6	-0.6	0.6	0.6	0.4	0.8	-0.7
Distance moved, locomotor task time 2	0.0	0.0	0.2	-0.0	0.0	-0.3	0.0	0.3	0.1	0.1	0.2	0.0	-0.1	-0.0	-0.0	-0.3	0.4
Vertical activity count, locomotor time 2	1.6	1.7	3.7	-1.1	-1.1	-1.5	1.1	1.5	1.2	1.2	1.3	1.1	-1.2	-1.1	-1.1	-1.6	1.9
Light reinforcement 1	0.3	0.5	1.1	0.6	1.0	0.6	-0.8	-0.6	-0.7	-0.7	-0.7	-0.7	0.7	0.8	0.8	0.8	-0.4
Light reinforcement 2	1.0	1.3	1.7	-1.3	-1.0	-1.3	1.0	1.2	1.2	1.2	1.2	1.2	-1.2	-1.2	-1.1	-1.2	1.0
Bone: marrow area	0.1	0.1	1.0	-0.1	-1.0	-0.3	0.4	0.2	0.3	0.3	0.3	0.3	-0.1	-0.3	-0.2	-0.3	-0.1
Bone: maximum diameter	0.3	0.6	1.4	0.8	0.5	0.8	-0.6	-0.8	-0.7	-0.7	-0.7	-0.6	0.9	0.7	0.7	0.7	-1.2
Bone: maximum force	0.1	0.2	0.3	-0.5	-0.3	-0.5	0.4	0.5	0.5	0.5	0.5	0.5	-0.4	-0.4	-0.3	-0.4	0.3
Bone: maximum moment	0.3	0.5	0.7	-0.7	-0.6	-0.8	0.8	0.7	0.8	0.8	0.7	0.9	-0.7	-0.6	-0.6	-0.7	0.5
Mean time between licks in bursts	0.1	0.2	0.3	0.2	0.2	0.5	-0.3	-0.4	-0.4	-0.4	-0.4	0.0	0.4	0.5	0.5	0.5	-0.4
Mean num. licks in bursts	0.5	0.6	0.9	-0.8	-0.7	-0.9	0.7	0.9	0.7	0.7	0.7	0.6	-0.7	-0.6	-0.7	-0.7	0.9
Cd content in liver	0.1	0.1	0.2	-0.4	-0.3	-0.4	0.4	0.4	0.4	0.4	0.4	-0.0	-0.4	-0.4	-0.4	-0.4	0.4
Co content in liver	1.2	1.4	1.9	-1.4	-1.2	-1.0	1.2	1.1	1.1	1.2	1.1	1.2	-1.2	-1.2	-1.2	-1.3	1.1
Cu content in liver	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.4	0.3	0.3	0.3	0.3	0.4	-0.3	-0.2	-0.3	-0.3	0.1
Fe content in liver	2.0	2.4	2.7	-1.4	-1.3	-1.6	1.6	1.6	1.6	1.6	1.6	1.5	-1.6	-1.6	-1.6	-1.5	1.4
K content in liver	0.5	0.5	0.7	0.5	0.6	0.7	-0.7	-0.8	-0.7	-0.7	-0.7	-0.6	0.7	0.8	0.7	0.6	-0.8
Mg content in liver	4.1	4.2	4.6	2.0	1.9	2.1	-2.1	-2.1	-2.1	-2.1	-2.1	-2.0	2.1	2.1	2.1	2.0	-1.9
Mn content in liver	0.0	0.0	0.1	0.1	0.3	0.2	-0.2	-0.2	-0.2	-0.2	-0.2	-0.0	0.2	0.1	0.2	0.2	-0.1
Na content in liver	0.1	0.1	0.3	-0.4	-0.6	-0.1	0.3	0.1	0.1	0.1	0.1	0.5	-0.1	-0.0	-0.1	-0.1	-0.0
Rb content in liver	0.2	0.2	0.4	-0.7	-0.6	-0.4	0.5	0.4	0.4	0.4	0.4	0.6	-0.4	-0.4	-0.4	-0.4	0.2
Se content in liver	1.8	2.2	2.8	-1.5	-1.4	-1.5	1.3	1.6	1.5	1.5	1.5	1.4	-1.5	-1.4	-1.5	-1.5	1.7
Sr content in liver	0.1	0.1	0.1	0.2	0.3	0.3	-0.2	-0.3	-0.3	-0.3	-0.3	-0.2	0.3	0.3	0.3	0.3	-0.3
Zn content in liver	2.4	2.7	3.2	1.8	1.4	1.6	-1.5	-1.7	-1.6	-1.6	-1.6	-1.8	1.7	1.7	1.7	1.7	-1.7
Bone: minimum diameter	0.7	1.4	1.8	-0.9	-1.3	-1.2	1.3	1.1	1.3	1.3	1.2	1.0	-1.1	-1.2	-1.3	-1.3	0.6
Time in familiar zone, hab. session 1	0.1	0.0	0.2	-0.4	-0.2	-0.2	0.2	0.2	0.2	0.2	0.2	0.3	-0.1	-0.2	-0.2	-0.1	-0.0
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.2	-0.6	-0.4	0.5	0.4	0.5	0.5	0.5	0.4	-0.5	-0.4	-0.4	-0.5	0.4
Total zone transitions, hab. session 1	1.1	1.6	2.2	-1.4	-1.5	-1.2	1.4	1.1	1.2	1.2	1.2	1.5	-1.2	-1.3	-1.2	-1.2	0.8
Total locomotion distance, hab. session 1	0.6	0.8	1.2	-1.1	-1.0	-0.8	0.9	0.8	0.9	0.9	0.9	1.1	-0.8	-0.9	-0.8	-0.9	0.5
Locomotion velocity, hab. session 1	0.1	0.2	0.3	-0.6	-0.5	-0.3	0.4	0.3	0.4	0.4	0.4	0.5	-0.3	-0.4	-0.3	-0.4	0.1
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.2	0.2	0.1	-0.3	-0.2	-0.2	-0.2	-0.2	-0.2	0.3	0.4	0.4	0.3	-0.3
Time in novel zone, hab. session 2	0.6	0.6	0.8	-0.7	-0.9	-0.6	0.8	0.7	0.8	0.8	0.8	0.7	-0.8	-0.9	-0.9	-0.9	0.7
Total zone transitions, hab. session 2	0.4	0.5	0.9	-0.7	-0.9	-0.7	0.7	0.7	0.7	0.7	0.7	0.6	-0.6	-0.7	-0.6	-0.7	0.6
Total locomotion distance, hab. session 2	0.3	0.3	0.5	-0.6	-0.7	-0.6	0.5	0.6	0.6	0.6	0.6	0.5	-0.5	-0.5	-0.5	-0.6	0.6
Locomotion velocity, hab. session 2	0.4	0.6	0.8	-0.7	-0.9	-0.8	0.7	0.8	0.7	0.7	0.7	0.7	-0.7	-0.7	-0.7	-0.7	0.8
Novel to familiar place preference ratio	0.1	0.1	0.2	0.4	0.4	0.4	-0.3	-0.4	-0.4	-0.4	-0.4	-0.3	0.4	0.3	0.3	0.5	-0.4
Novelty place preference	0.0	0.0	0.1	0.3	0.2	0.2	-0.1	-0.2	-0.2	-0.2	-0.2	-0.2	0.2	0.1	0.1	0.3	-0.2
Time in novel zone, NPP test	0.0	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	-0.1	-0.1	-0.1	0.0	0.1	-0.0	-0.0	0.1	-0.1
Total zone transitions, NPP test	1.1	1.6	2.1	-1.4	-1.4	-1.2	1.3	1.2	1.3	1.3	1.2	1.2	-1.2	-1.4	-1.2	-1.4	1.1
Total locomotion distance, NPP test	0.3	0.4	0.6	-0.7	-0.6	-0.7	0.6	0.7	0.6	0.6	0.6	0.5	-0.6	-0.7	-0.6	-0.7	0.7
Locomotion velocity, NPP test	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.4	0.5	0.5	0.5	0.5	0.4	-0.5	-0.6	-0.5	-0.6	0.6
Intraocular pressure	0.1	0.1	0.3	-0.1	-0.3	0.1	0.3	0.2	0.3	0.3	0.3	0.1	-0.5	-0.3	-0.5	-0.5	0.4
Delta distance traveled before/after self-admin	0.1	0.1	0.5	-0.4	-0.4	-0.2	0.4	-0.0	0.3	0.3	0.3	0.4	-0.2	-0.4	-0.4	-0.1	-0.7
Delta ambulatory time before/after self-admin	0.2	0.2	1.5	0.2	0.2	0.4	-0.2	-0.6	-0.3	-0.3	-0.3	-0.2	0.4	0.2	0.2	0.5	-1.2
Parametrial fat weight	0.6	1.2	1.9	-1.3	-1.1	-1.0	1.2	1.0	1.1	1.1	1.1	1.4	-1.1	-1.1	-1.1	-1.1	0.6
Pavlov. Cond. lever latency	0.4	0.5	0.6	0.7	0.7	0.5	-0.8	-0.5	-0.7	-0.7	-0.7	-0.8	0.7	0.7	0.7	0.8	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	0.3	0.4	0.6	-0.4	-0.5	-0.5	-0.5	-0.5	-0.3	0.4	0.4	0.4	0.4	-0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.2	0.2	0.4	-0.2	-0.3	-0.3	-0.3	-0.3	-0.2	0.2	0.3	0.3	0.2	-0.2
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.1	0.0	0.1	0.1	0.1	0.1	-0.0	-0.1	-0.0	-0.2	0.0
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.1	0.0	0.1	0.1	0.1	0.1	-0.0	-0.1	-0.0	-0.2	0.0
Pavlov. Cond. lever contacts	0.5	0.6	0.8	-0.7	-0.8	-0.7	0.8	0.7	0.8	0.8	0.8	0.7	-0.7	-0.8	-0.7	-0.9	0.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	-0.4	-0.6	-0.6	0.5	0.5	0.5	0.5	0.5	0.4	-0.5	-0.5	-0.5	-0.4	0.4
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.9	0.7	0.9	0.8	-0.7	-0.8	-0.8	-0.8	-0.8	-0.7	0.7	0.7	0.7	0.7	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1	-0.1	-0.1	-0.0	0.1	0.1	0.1	-0.0	-0.1
Pavlov. Cond. response bias	0.3	0.3	0.4	-0.7	-0.4	-0.5	0.6	0.5	0.6	0.6	0.6	0.6	-0.6	-0.6	-0.5	-0.6	0.5
Pavlov. Cond. lever latency	10.0	13.5	15.6	-3.9	-4.0	-3.8	3.7	3.7	3.6	3.6	3.6	3.8	-3.6	-3.5	-3.6	-3.6	3.4
Pavlov. Cond. magazine entry latency	8.1	9.3	10.7	3.1	3.0	3.1	-3.0	-3.2	-3.0	-3.0	-3.0	-3.0	3.0	3.0	3.0	3.0	-3.3
Pavlov. Cond. change in total contacts	8.6	11.9	13.7	3.5	3.7	3.5	-3.5	-3.5	-3.4	-3.4	-3.4	-3.4	3.4	3.3	3.4	3.4	-3.4
Pavlov. Cond. index score	9.4	12.1	13.1	3.6	3.6	3.6	-3.5	-3.6	-3.4	-3.4	-3.4	-3.5	3.4	3.3	3.3	3.4	-3.5
Pavlov. Cond. latency score	10.0	12.4	13.4	3.7	3.6	3.7	-3.5	-3.6	-3.5	-3.5	-3.5	-3.6	3.5	3.4	3.4	3.4	-3.6
Pavlov. Cond. lever contacts	8.3	11.3	13.2	3.6	3.6	3.4	-3.5	-3.4	-3.3	-3.3	-3.3	-3.5	3.3	3.2	3.2	3.2	-3.1
Pavlov. Cond. magazine entry number	4.7	5.7	6.4	-2.5	-2.3	-2.5	2.4	2.5	2.3	2.3	2.4	2.4	-2.4	-2.3	-2.3	-2.3	2.5
Pavlov. Cond. intertrial magazine entries	0.8	1.1	1.2	-1.1	-0.9	-1.1	1.1	1.1	1.1	1.1	1.1	1.0	-1.1	-1.1	-1.1	-1.1	1.0
Pavlov. Cond. lever-magazine prob. diff.	9.6	12.2	13.0	3.6	3.6	3.6	-3.5	-3.6	-3.4	-3.4	-3.4	-3.5	3.5	3.3	3.4	3.4	-3.5
Pavlov. Cond. response bias	7.6	10.3	11.9	3.5	3.4	3.2	-3.3	-3.2	-3.2	-3.2	-3.2	-3.4	3.2	3.1	3.1	3.1	-3.0
Time in closed arm before self-admin	2.9	3.3	4.0	1.8	1.8	1.9	-1.8	-1.8	-1.9	-1.9	-1.9	-1.8	1.9	1.8	2.0	1.7	-1.3
Time in closed arm after self-admin	0.1	0.1	0.1	0.3	0.3	0.4	-0.3	-0.3	-0.4	-0.4	-0.4	-0.3	0.4	0.3	0.3	0.3	0.0
Time in open arm before self-admin	1.1	1.2	1.3	-1.1	-1.1	-1.1	1.1	1.0	1.2	1.2	1.1	1.1	-1.2	-1.1	-1.0	-1.0	0.6
Time in open arm after self-admin	0.1	0.1	0.2	-0.2	-0.2	-0.4	0.2	0.4	0.3	0.3	0.4	0.2	-0.4	-0.2	-0.4	-0.4	0.4
Bone: periosteal estimation	0.1	0.2	0.5	-0.2	-0.7	-0.5	0.5	0.3	0.5	0.5	0.4	0.3	-0.3	-0.4	-0.4	-0.5	-0.1
Bone: periosteal perimeter	0.2	0.4	0.9	0.7	0.5	0.6	-0.5	-0.7	-0.5	-0.5	-0.6	-0.6	0.7	0.5	0.6	0.5	-0.9
Bone: post-yield work	0.0	0.0	0.2	0.2	-0.0	0.0	-0.0	-0.1	0.0	-0.0	-0.0	0.0	0.1	0.1	0.1	0.0	-0.4
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	0.4	0.5	0.5	-0.4	-0.5	-0.4	-0.4	-0.4	-0.4	0.4	0.4	0.5	0.3	-0.6
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	0.4	0.4	0.5	-0.4	-0.5	-0.4	-0.4	-0.4	-0.4	0.4	0.4	0.5	0.3	-0.5
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.5	-0.3	-0.3	-0.4	0.3	0.4	0.3	0.3	0.4	0.3	-0.4	-0.4	-0.5	-0.5	0.7
Progressive ratio test 2 active lever presses	1.2	1.3	1.8	1.1	1.1	1.1	-1.0	-1.1	-1.2	-1.2	-1.2	-1.1	1.1	1.0	1.1	1.3	-1.1
Progressive ratio test 2 breakpoint	1.0	1.2	1.7	1.0	1.1	1.1	-1.0	-1.1	-1.1	-1.1	-1.1	-1.0	1.1	0.9	1.1	1.3	-1.1
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	0.0	0.1	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.0	0.0	-0.1	0.1	0.1	-0.2
Incentive Sensitization - Responses	5.5	5.6	7.2	2.4	2.4	2.3	-2.3	-2.3	-2.4	-2.4	-2.4	-2.4	2.4	2.3	2.4	2.7	-2.0
Incentive Sensitization - Breakpoint	5.1	5.2	6.8	2.3	2.3	2.2	-2.2	-2.2	-2.3	-2.3	-2.3	-2.3	2.3	2.2	2.3	2.6	-2.0
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.1	-0.4	-0.3	-0.7	0.4	0.7	0.5	0.6	0.6	0.4	-0.6	-0.4	-0.7	-0.7	1.0
Progressive ratio	1.0	1.2	2.1	1.1	1.2	1.0	-1.1	-1.2	-1.0	-1.0	-1.0	-1.1	1.0	1.0	0.9	1.1	-1.4
Food seeking constrained by brief footshock	0.2	0.2	0.9	0.5	0.7	0.2	-0.6	-0.0	-0.5	-0.5	-0.4	-0.5	0.3	0.4	0.4	0.1	1.0
Seeking ratio, punishment vs. effort	0.2	0.3	1.4	-0.5	-0.4	-0.5	0.4	0.7	0.4	0.4	0.4	0.5	-0.5	-0.5	-0.4	-0.5	1.2
Retroperitoneal fat weight	0.1	0.5	1.0	0.5	0.7	0.9	-0.6	-0.9	-0.6	-0.6	-0.6	-0.7	0.6	0.5	0.5	0.6	-1.0
Reaction time number correct	0.4	0.6	0.9	0.8	0.7	0.9	-0.6	-0.9	-0.8	-0.8	-0.8	-0.8	0.8	0.8	0.9	0.7	-0.8
Reaction time mean minus median	1.0	1.3	1.6	1.2	1.1	1.1	-1.2	-1.1	-1.2	-1.2	-1.2	-1.2	1.1	1.1	1.0	1.1	-1.0
Reaction time mean minus median AUC	0.1	0.1	0.3	0.5	0.4	0.4	-0.5	-0.3	-0.4	-0.4	-0.4	-0.6	0.3	0.4	0.2	0.2	-0.0
Reaction time num false alarms	0.3	0.4	0.5	-0.6	-0.5	-0.5	0.6	0.5	0.7	0.7	0.7	0.6	-0.7	-0.7	-0.7	-0.6	0.3
Reaction time num false alarms AUC	0.5	0.7	0.9	-0.9	-0.7	-0.7	0.8	0.6	0.9	0.9	0.9	0.8	-0.9	-0.9	-0.9	-0.8	0.2
Reaction time trials correct on left	0.4	0.6	0.9	0.8	0.7	0.9	-0.6	-0.9	-0.8	-0.8	-0.8	-0.8	0.8	0.8	0.9	0.7	-0.8
Reaction time trials on left	0.5	0.6	0.9	0.8	0.7	0.9	-0.6	-0.9	-0.8	-0.8	-0.8	-0.8	0.8	0.8	0.9	0.7	-0.8
Reaction time mean	0.5	0.7	0.9	0.9	0.8	0.9	-0.9	-0.9	-0.9	-0.9	-0.9	-0.9	0.8	0.8	0.9	0.9	-0.7
Reaction time mean AUC	0.5	0.7	0.9	0.9	0.8	0.9	-0.9	-0.8	-0.9	-0.9	-0.9	-0.9	0.8	0.8	0.8	0.8	-0.6
Median of all reaction times	0.8	1.1	1.3	1.1	1.0	1.1	-1.1	-1.0	-1.1	-1.1	-1.1	-1.0	1.0	1.0	1.1	1.1	-0.7
Reaction time omissions	0.0	0.0	0.0	-0.0	-0.2	-0.0	0.0	0.0	-0.0	0.0	0.0	-0.1	0.0	-0.1	-0.1	0.0	0.1
Reaction time false alarm rate	1.2	1.7	2.2	-1.3	-1.2	-1.3	1.2	1.2	1.4	1.4	1.4	1.4	-1.4	-1.4	-1.5	-1.3	0.9
Reaction time premature initiation rate	0.6	0.8	1.2	-1.1	-0.8	-0.6	1.0	0.7	0.9	0.9	0.9	1.0	-1.0	-1.1	-0.9	-0.9	0.3
Reaction time premature initiations	0.1	0.1	0.2	-0.5	-0.3	0.1	0.5	0.0	0.3	0.3	0.3	0.4	-0.4	-0.5	-0.2	-0.3	-0.4
Std. dev. reaction times	0.2	0.3	0.7	0.5	0.3	0.6	-0.5	-0.6	-0.5	-0.5	-0.5	-0.5	0.5	0.4	0.5	0.5	-0.8
Reaction time trials completed	0.5	0.6	0.9	0.8	0.7	0.9	-0.6	-0.9	-0.8	-0.8	-0.8	-0.8	0.8	0.8	0.9	0.7	-0.8
Reaction time trials AUC	0.5	0.7	0.9	0.8	0.7	0.9	-0.7	-0.9	-0.8	-0.8	-0.8	-0.8	0.8	0.8	0.9	0.7	-0.8
Run reversals in cocaine runway, females	0.5	0.5	3.0	0.3	0.3	0.7	-0.3	-0.9	-0.4	-0.5	-0.5	-0.3	0.6	0.4	0.6	0.7	-1.7
Run reversals in cocaine runway, males	0.6	0.6	0.9	-0.9	-0.9	-0.6	0.9	0.7	0.8	0.8	0.8	0.9	-0.7	-0.9	-0.7	-0.7	0.5
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.2	0.3	0.3	0.3	0.3	0.3	-0.3	-0.2	-0.4	-0.3	0.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.1	-0.1	-0.4	0.1	0.4	0.3	0.3	0.3	0.1	-0.3	-0.1	-0.5	-0.4	0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.4	-0.3	-0.2	0.4	0.1	0.3	0.3	0.2	0.4	-0.2	-0.4	-0.2	-0.1	-0.4
Std. dev. time between licks in bursts	0.9	1.1	2.1	0.9	0.9	1.4	-0.8	-1.2	-1.0	-1.0	-1.1	-0.6	1.0	1.0	1.0	1.0	-1.4
Total sessions with >9 infusions	2.2	2.4	5.0	1.4	1.4	1.6	-1.4	-1.7	-1.4	-1.5	-1.5	-1.4	1.5	1.3	1.7	1.5	-2.2
Short access day 1 total inactive lever presses	1.6	1.7	2.0	-1.3	-1.3	-1.3	1.4	1.3	1.3	1.3	1.3	1.3	-1.3	-1.4	-1.3	-1.2	1.1
Short access day 10 total inactive lever presses	6.5	7.3	8.3	-2.8	-2.8	-2.6	2.9	2.6	2.7	2.7	2.7	2.8	-2.7	-2.9	-2.8	-2.5	2.0
Short access day 1 total infusions	0.0	0.0	0.0	0.2	0.2	-0.1	-0.1	0.0	-0.0	-0.0	-0.0	-0.2	0.1	0.1	0.2	-0.0	0.0
Short access day 10 total infusions	0.1	0.1	0.4	0.3	0.3	0.4	-0.2	-0.5	-0.4	-0.4	-0.4	-0.3	0.4	0.2	0.5	0.3	-0.6
Short access total infusions	0.0	0.0	0.0	0.1	0.2	0.1	-0.1	-0.0	-0.1	-0.1	-0.1	-0.1	0.1	0.1	0.2	-0.0	0.1
Short access day 1 locomotion	0.1	0.1	0.2	0.3	0.3	0.3	-0.3	-0.4	-0.4	-0.4	-0.4	-0.3	0.4	0.3	0.5	0.4	-0.4
Short access day 10 total locomotion	0.0	0.0	0.1	0.2	0.2	0.3	-0.1	-0.2	-0.3	-0.3	-0.2	-0.2	0.2	0.1	0.1	0.2	0.0
Short access total locomotion	0.5	0.5	0.7	0.7	0.7	0.8	-0.7	-0.8	-0.8	-0.8	-0.8	-0.7	0.7	0.6	0.7	0.8	-0.6
One hour access (0.3 mA shock)	1.0	1.2	1.7	1.0	1.0	1.2	-0.9	-1.2	-1.1	-1.1	-1.1	-1.0	1.1	0.9	1.1	1.2	-1.3
Compulsive drug intake	1.7	1.7	2.0	-1.4	-1.4	-1.3	1.4	1.3	1.4	1.4	1.3	1.4	-1.4	-1.3	-1.4	-1.2	0.9
One hour access (shock baseline)	1.2	1.4	1.6	1.1	1.1	1.3	-1.1	-1.2	-1.2	-1.2	-1.2	-1.1	1.2	1.0	1.2	1.2	-1.1
Social response proportion	0.4	0.5	0.9	0.7	1.0	0.7	-0.8	-0.7	-0.7	-0.7	-0.6	-0.8	0.6	0.7	0.6	0.5	-0.4
Social responses	2.7	3.5	5.7	1.8	2.4	1.9	-2.0	-1.8	-1.9	-1.8	-1.8	-1.9	1.7	1.9	1.8	1.7	-1.4
Social time	0.5	0.6	1.1	-0.8	-0.7	-0.6	0.7	0.7	0.8	0.8	0.8	0.5	-0.9	-0.9	-1.0	-1.0	0.7
Soleus weight	0.0	0.1	0.3	-0.1	-0.5	-0.3	0.3	0.2	0.2	0.2	0.2	0.2	-0.2	-0.0	-0.1	-0.2	0.1
Bone: stiffness	0.0	0.0	0.1	-0.2	0.1	-0.3	0.1	0.2	0.2	0.2	0.2	0.2	-0.1	-0.1	-0.1	-0.1	0.0
Tibialis anterior weight	1.8	6.1	7.3	-2.6	-2.3	-2.7	2.5	2.5	2.5	2.5	2.5	2.4	-2.5	-2.5	-2.5	-2.4	2.1
Time to tail flick, vehicle, before self-admin	0.7	0.7	2.8	-0.7	-0.7	-0.8	0.6	1.0	0.7	0.7	0.7	0.7	-0.8	-0.6	-0.7	-0.9	1.7
Time to tail flick, vehicle, after self-admin	0.5	0.5	0.7	-0.7	-0.7	-0.8	0.7	0.7	0.7	0.7	0.7	0.7	-0.7	-0.7	-0.6	-0.8	0.7
Time to tail flick, test, before self-admin	0.2	0.2	0.2	-0.4	-0.4	-0.4	0.4	0.4	0.4	0.4	0.4	0.4	-0.4	-0.4	-0.4	-0.5	0.5
Time to tail flick, test, after self-admin	2.5	2.6	3.0	-1.7	-1.7	-1.6	1.7	1.5	1.7	1.7	1.7	1.7	-1.6	-1.7	-1.5	-1.6	1.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.2	-0.0	-0.0	-0.1	0.0	-0.1	0.1	0.0	0.0	0.0	0.0	-0.1	0.1	0.0	-0.5
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	-0.5	-0.4	-0.4	0.5	0.3	0.4	0.4	0.4	0.5	-0.3	-0.5	-0.2	-0.3	-0.0
Tibia length	0.0	0.1	0.2	0.2	0.0	0.3	-0.3	-0.4	-0.3	-0.3	-0.3	-0.2	0.4	0.5	0.4	0.4	-0.4
Ambulatory time before self-admin	6.4	6.6	7.1	-2.6	-2.6	-2.5	2.6	2.6	2.6	2.6	2.6	2.6	-2.6	-2.6	-2.5	-2.7	2.5
Ambulatory time after self-admin	2.9	3.2	3.8	-1.9	-2.0	-1.7	1.9	1.6	1.9	1.9	1.8	1.9	-1.8	-1.9	-1.9	-1.8	1.0
Bone: tissue strength	0.1	0.1	0.1	0.1	0.4	0.2	-0.2	-0.2	-0.2	-0.2	-0.2	0.2	0.2	0.3	0.3	0.3	-0.2
Total heroin consumption	1.4	1.6	2.4	1.2	1.2	1.3	-1.2	-1.4	-1.3	-1.3	-1.3	-1.2	1.3	1.2	1.2	1.4	-1.5
Bone: trabecular number	1.6	2.4	3.1	-1.6	-1.8	-1.5	1.7	1.5	1.6	1.6	1.6	1.7	-1.6	-1.5	-1.5	-1.5	1.2
Bone: trabecular spacing	0.6	0.7	1.6	0.7	1.3	0.8	-0.9	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	0.7	0.8	0.8	-0.6
Bone: trabecular thickness	0.3	0.3	0.4	-0.6	-0.6	-0.6	0.6	0.6	0.6	0.6	0.6	0.6	-0.6	-0.5	-0.6	-0.5	0.5
Bone: trabecular tissue density	2.8	3.9	4.4	2.1	1.9	2.0	-2.0	-2.0	-2.0	-2.0	-2.0	-1.6	2.1	2.0	2.0	2.0	-2.0
Water consumed over 24 hours	2.4	2.8	3.8	-1.6	-1.5	-1.8	1.7	1.8	1.7	1.7	1.7	1.9	-1.6	-1.6	-1.6	-1.6	1.6
Number of responses in last shaping day	3.6	3.8	4.3	-1.8	-1.8	-2.1	1.9	2.0	1.9	1.9	2.0	1.8	-2.0	-1.9	-1.9	-2.0	2.0