Hub : Genes

Plpp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Plpp2	0.08	0.06	2.3e-04	0.03	0.03	0.03	0.03	1.1e-04	1.8e-04	1.6e-04	1.3e-04
2	IL	gene expression	Plpp2	0.16	0.13	2.5e-03	0.07	0.07	0.06	0.07	7.4e-03	8.8e-03	1.2e-02	1.1e-02
3	Adipose	gene expression	Plpp2	0.34	0.16	0.0e+00	0.34	0.34	0.34	0.34	7.7e-39	5.3e-39	1.1e-38	1.3e-38

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.6	0.9	1.3	0.9	-0.9	1.1
Area under the delay curve	2.4	2.5	2.7	-1.6	-1.6	1.5
BMI with tail	6.4	20.8	22.9	-4.8	-4.5	4.4
BMI without tail	2.5	5.1	8.4	-2.9	-2.0	1.7
Body weight	1.1	4.8	5.8	-2.4	-2.2	2.0
Weight adjusted by age	0.6	0.7	1.7	-1.3	-0.4	0.4
Bone surface	0.8	1.5	3.6	1.9	-0.4	0.8
Bone volume	0.8	1.4	3.0	1.7	-0.6	0.9
Breakpoint value in progressive ratio session	5.6	6.1	7.0	2.2	2.7	-2.6
Number of licking bursts	0.2	0.2	0.6	-0.8	0.0	-0.2
Context. condit. distance diff. score	0.2	0.2	0.4	-0.7	-0.4	0.0
Locomotion velocity, session 1	0.6	0.6	1.6	1.3	0.5	-0.2
Locomotion distance, session 1	0.5	0.7	2.0	1.4	-0.2	-0.0
Locomotion velocity, session 2	4.4	5.1	8.9	3.0	1.7	-1.9
Locomotion distance, session 2	1.8	2.5	6.4	2.5	0.9	-0.6
Locomotion velocity, session 3	7.0	8.1	9.6	2.5	2.9	-3.1
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	0.1	-0.3
Stereotopy head waving bouts, day 3	5.9	7.0	8.1	2.8	2.4	-2.6
Stereotopy head waving duration, day 3	6.6	8.0	8.4	2.9	2.7	-2.8
Locomotion velocity, session 7	0.7	0.8	1.7	0.4	0.6	-1.3
Locomotion distance, session 7	0.3	0.3	1.0	-1.0	-0.3	-0.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	0.7	-0.0	0.0
Stereotopy head waving duration, day 7	0.4	0.4	1.2	1.1	0.3	-0.2
Locomotion velocity, session 8	0.9	1.0	2.4	1.6	0.4	-0.7
Locomotion distance, session 8	0.3	0.4	0.8	0.9	0.3	-0.5
Degree of sensitization distance	0.4	0.4	0.6	-0.7	-0.8	0.5
Degree of sensitization stereotypy	1.8	1.9	2.6	-1.0	-1.5	1.6
Conditioned locomotion	1.5	1.8	3.6	-1.9	-1.0	0.8
Cocaine response after cond. corrected	5.8	6.5	11.1	-3.3	-2.1	2.0
Cocaine response after cond. not corrected	5.9	6.5	11.5	-3.4	-2.1	2.0
Cocaine response before conditioning	0.6	0.7	0.8	0.9	0.7	-0.9
Saline control response	0.0	0.0	0.1	-0.3	-0.2	0.2
Bone: connectivity density	0.6	0.9	1.6	0.4	-1.1	1.3
Bone: cortical apparent density	1.0	1.3	1.8	-1.0	-1.0	1.3
Bone: cortical area	0.6	1.0	1.5	-0.5	-1.2	1.1
Bone: cortical porosity	0.4	0.5	1.0	1.0	0.5	-0.4
Bone: cortical porosity	0.2	0.2	0.5	0.7	-0.2	0.2
Bone: cortical thickness	1.3	2.1	2.5	-1.1	-1.6	1.6
Bone: cortical thickness	0.2	0.2	0.5	-0.7	0.2	-0.2
Bone: cortical tissue density	0.7	0.9	1.3	-0.8	-0.8	1.1
Condit. Reinf. active minus inactive responses	5.0	5.7	5.9	2.3	2.4	-2.4
Condit. Reinf. active-inactive response ratio	2.3	2.5	3.4	1.2	1.8	-1.6
Condit. Reinf. active responses	4.1	5.0	7.0	2.6	2.0	-2.0
Condit. Reinf. inactive responses	1.0	1.2	2.9	1.7	0.6	-0.6
Incentive salience index mean	2.8	3.4	4.6	2.1	1.6	-1.7
Condit. Reinf. lever presses	0.4	0.5	1.2	1.1	-0.4	0.4
Condit. Reinf. active minus inactive responses	1.9	2.3	3.3	1.0	1.8	-1.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.4	0.5	-0.0
Condit. Reinf. active responses	1.7	2.4	3.0	1.2	1.7	-1.7
Condit. Reinf. inactive responses	1.1	1.4	2.1	0.9	1.1	-1.4
Condit. Reinf. lever presses	2.1	2.9	3.8	1.2	1.9	-1.8
Condit. Reinf. lever reinforcers received	1.3	1.8	2.4	0.8	1.6	-1.5
Conditioned reinforcement - actives	1.9	1.9	2.2	1.5	1.4	-1.3
Conditioned reinforcement - inactives	0.4	0.4	0.9	-1.0	-0.5	0.4
Conditioned locomotion	6.8	8.2	8.3	2.9	2.9	-2.8
Patch foraging indifference point 0 sec	0.2	0.3	0.5	-0.3	-0.6	0.7
Patch foraging indifference point AUC	0.7	0.8	0.9	0.9	1.0	-0.9
Delay disc. indifference point, 0s delay	7.3	8.0	11.0	-1.7	-3.2	3.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.3	-0.3	0.3
Delay disc. indifference point, 2s delay	5.5	6.1	7.4	-2.1	-2.7	2.5
Delay disc. indifference point, 24s delay	0.9	0.9	1.2	-1.1	-0.8	0.8
Delay disc. indifference point, 4s delay	0.8	0.9	1.1	-0.8	-1.0	0.9
Delay disc. indifference point, 8s delay	1.6	1.6	2.6	-1.6	-1.1	0.9
Indifference point function ln k	0.3	0.4	0.7	-0.8	-0.5	0.4
Indifference point function log k	0.3	0.4	0.7	-0.8	-0.5	0.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.2	-0.4	-0.5	0.5
Patch foraging total patch changes 12 sec	0.4	0.6	1.0	-1.0	-0.7	0.6
Patch foraging total patch changes 18 sec	1.1	1.4	1.5	1.2	1.2	-1.1
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.4	0.2	-0.0
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.6	0.4	-0.1
Patch foraging time to switch 0 sec	1.1	1.7	2.8	-0.3	-1.7	1.5
Patch foraging water rate 0 sec	0.4	0.6	1.2	-1.1	0.4	-0.6
Patch foraging water rate 12 sec	1.3	1.9	4.7	-2.2	-0.8	0.7
Patch foraging water rate 18 sec	0.8	1.1	1.8	-1.4	0.8	-0.9
Patch foraging water rate 24 sec	1.0	1.3	4.0	-2.0	-0.0	-0.2
Patch foraging water rate 6 sec	0.5	0.7	1.1	-0.6	0.9	-1.0
Seeking ratio, delayed vs. immediate footshock	4.3	4.9	5.7	2.4	2.1	-2.1
Distance traveled before self-admin	0.7	0.8	1.2	-0.5	-0.9	1.1
Distance traveled after self-admin	0.4	0.5	0.8	0.9	0.6	-0.5
Extensor digitorum longus weight	4.5	17.7	24.6	-5.0	-4.1	3.4
Bone: elastic displacement	0.1	0.1	0.2	0.4	0.4	-0.0
Bone: elastic work	0.4	0.5	0.7	-0.6	-0.6	0.8
Bone: endosteal estimation	0.1	0.3	0.3	-0.6	-0.6	0.4
Bone: endosteal perimeter	0.3	0.5	0.9	1.0	0.5	-0.7
Epididymis fat weight	0.3	0.7	0.9	0.8	1.0	-0.8
Delta time in closed arm before/after self-admin	1.2	1.2	3.2	-1.8	-0.4	0.3
Delta time in open arm before/after self-admin	1.3	1.2	1.7	-0.8	-1.2	1.3
Diff in mean of infusions in LGA sessions	2.1	2.3	2.4	1.5	1.6	-1.5
Delay discount exponential model param	2.2	2.3	2.5	1.6	1.6	-1.4
Extinction: sum of active levers before priming	1.2	1.2	1.8	0.7	1.2	-1.3
Active lever presses in extinction session 6	2.3	2.2	2.7	1.7	1.5	-1.3
Bone: final force	1.4	2.2	2.9	-1.3	-1.7	1.4
Bone: final moment	1.1	1.8	2.3	-1.2	-1.5	1.3
Food consumed during 24 hour testing period	0.6	0.8	1.2	-1.1	-0.8	0.7
Glucose	1.5	2.2	2.4	-1.5	-1.4	1.5
Heart weight	0.2	0.3	0.7	0.3	0.8	-0.4
Delay discount hyperbolic model param	3.0	3.2	3.5	1.8	1.9	-1.7
Intermittent access intake day 1-15 change	6.2	6.1	6.9	2.3	2.6	-2.5
Intermittent access intake escalation	5.7	5.6	7.1	1.8	2.7	-2.6
Intermittent access intake escalation 2	6.8	6.8	8.7	2.0	2.9	-2.7
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.2	-0.2	0.5	-0.5
Intermitt. access day 15 inactive lever presses	0.5	0.6	0.8	0.5	0.8	-0.9
Intermitt. access escalation Index	0.3	0.3	0.4	0.1	-0.6	0.6
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.1	-0.2	0.2
Intermittent access day 15 total infusions	1.9	2.2	2.6	1.2	1.6	-1.6
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.2	1.0	1.1	-1.1
Intermittent access total infusions	0.2	0.3	0.3	0.4	0.5	-0.6
Intermittent access day 1 locomotion	0.5	0.5	0.7	0.6	0.8	-0.8
Intermittent access day 15 total locomotion	3.8	4.1	4.3	1.9	2.1	-2.1
Intermittent access total locomotion	1.0	1.1	1.3	1.1	1.0	-1.0
Intermittent access standard deviation	2.5	2.7	3.3	1.2	1.8	-1.8
Left kidney weight	0.0	0.1	0.2	0.4	-0.0	-0.0
Right kidney weight	1.2	3.4	3.5	1.9	1.9	-1.8
Cocaine induced anxiety	0.5	0.6	1.6	1.3	0.4	-0.3
Post-drug Anxiety	0.6	0.6	1.6	1.3	0.5	-0.4
Baseline Anxiety	0.3	0.3	0.5	-0.0	0.6	-0.7
Tail length	3.0	9.2	11.1	2.6	3.1	-3.3
Length with tail	1.8	6.6	7.2	2.7	2.5	-2.5
Length without tail	0.1	0.2	0.7	0.9	0.1	-0.0
Times rat made contact with spout	0.3	0.3	0.8	-0.9	-0.3	0.1
Lifetime Intake	0.1	0.1	0.1	0.3	0.3	-0.4
Liver weight, left	2.0	3.2	3.9	-2.0	-1.7	1.7
Liver weight, right	1.4	2.4	2.8	-1.4	-1.7	1.5
Locomotor activity	2.5	4.0	6.4	2.5	1.6	-1.7
Locomotor testing distance	1.5	2.5	3.9	2.0	1.4	-1.3
Locomotor testing rearing	0.1	0.1	0.1	-0.3	0.2	-0.3
Locomotion in novel chamber	0.1	0.1	0.3	0.0	0.5	-0.4
Locomotion in novel chamber post-restriction	1.0	1.2	1.9	0.6	1.1	-1.4
Fecal boli incidents, locomotor time 1	1.8	2.0	2.5	-1.6	-1.4	1.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.4	0.2	-0.3
Time >=10cm from walls, locomotor time 1	1.1	1.1	1.9	-0.4	-1.2	1.4
Bouts of movement, locomotor time 1	0.3	0.3	0.7	0.2	0.4	-0.8
Total resting periods, locomotor time 1	0.3	0.4	0.7	0.4	0.5	-0.9
Rest time, locomotor task time 1	0.5	0.5	0.8	0.7	0.5	-0.9
Distance moved, locomotor task time 1	1.0	1.1	2.1	-0.3	-1.1	1.4
Vertical activity count, locomotor time 1	0.4	0.5	0.8	-0.9	-0.3	0.7
Time >=10cm from walls, locomotor time 2	2.0	2.1	2.8	-1.7	-1.4	1.2
Bouts of movement, locomotor time 2	0.7	0.7	1.7	1.3	0.5	-0.4
Total resting periods, locomotor time 2	0.6	0.7	1.6	1.3	0.5	-0.4
Rest time, locomotor task time 2	0.6	0.7	1.2	1.1	0.6	-0.6
Distance moved, locomotor task time 2	0.7	0.8	1.2	-1.1	-0.8	0.8
Vertical activity count, locomotor time 2	0.9	1.0	2.1	-1.5	-0.7	0.6
Light reinforcement 1	6.1	11.2	13.9	3.7	3.2	-3.1
Light reinforcement 2	2.0	2.7	3.8	2.0	1.5	-1.4
Bone: marrow area	0.1	0.3	0.3	-0.6	-0.6	0.4
Bone: maximum diameter	0.7	1.2	2.3	1.5	0.8	-0.8
Bone: maximum force	1.3	2.3	2.6	-1.5	-1.6	1.4
Bone: maximum moment	1.1	1.8	2.1	-1.3	-1.4	1.3
Mean time between licks in bursts	4.2	5.9	6.4	2.2	2.5	-2.5
Mean num. licks in bursts	0.0	0.0	0.1	0.1	-0.2	0.3
Cd content in liver	0.3	0.3	0.4	-0.4	-0.7	0.7
Co content in liver	0.5	0.6	1.0	0.6	0.8	-1.0
Cu content in liver	0.2	0.2	0.5	0.1	-0.7	0.5
Fe content in liver	0.2	0.2	0.5	-0.1	0.3	-0.7
K content in liver	0.2	0.1	0.2	0.5	-0.4	-0.0
Mg content in liver	0.2	0.2	0.2	0.5	-0.5	0.2
Mn content in liver	1.2	1.3	3.3	1.8	0.4	-0.7
Na content in liver	0.8	0.9	1.8	-0.4	-1.4	0.8
Rb content in liver	0.5	0.6	0.9	-0.0	-1.0	0.9
Se content in liver	0.4	0.4	0.8	0.6	0.4	-0.9
Sr content in liver	0.1	0.1	0.2	-0.4	0.3	-0.4
Zn content in liver	1.8	2.0	3.0	0.5	1.7	-1.6
Bone: minimum diameter	0.0	0.0	0.0	0.1	-0.2	-0.1
Time in familiar zone, hab. session 1	2.3	2.1	2.6	1.1	1.6	-1.6
Time in novel zone, hab. session 1	1.2	1.2	1.7	-0.6	-1.2	1.3
Total zone transitions, hab. session 1	1.1	1.6	3.6	1.9	0.8	-0.8
Total locomotion distance, hab. session 1	1.3	1.9	4.5	2.1	0.6	-0.9
Locomotion velocity, hab. session 1	1.9	2.6	5.5	2.3	0.9	-1.2
Time in familiar zone, hab. session 2	6.5	6.7	8.5	2.1	2.9	-2.7
Time in novel zone, hab. session 2	5.1	5.1	6.2	-1.8	-2.5	2.4
Total zone transitions, hab. session 2	0.6	0.8	0.9	0.9	-0.8	0.9
Total locomotion distance, hab. session 2	1.3	1.7	4.1	2.0	0.8	-0.7
Locomotion velocity, hab. session 2	1.4	1.9	4.9	2.2	0.7	-0.6
Novel to familiar place preference ratio	4.5	4.7	6.1	-1.5	-2.4	2.5
Novelty place preference	2.8	2.8	3.9	-1.0	-1.9	2.0
Time in novel zone, NPP test	3.1	3.1	4.0	-1.2	-2.0	2.0
Total zone transitions, NPP test	0.3	0.4	0.9	1.0	-0.3	0.5
Total locomotion distance, NPP test	0.2	0.3	0.7	0.8	-0.4	0.3
Locomotion velocity, NPP test	0.3	0.4	1.3	1.1	-0.1	0.2
Intraocular pressure	0.2	0.3	0.5	-0.7	0.5	-0.3
Delta distance traveled before/after self-admin	1.9	2.0	2.3	1.4	1.4	-1.5
Delta ambulatory time before/after self-admin	2.1	2.3	2.4	1.5	1.4	-1.6
Parametrial fat weight	0.4	0.8	1.1	0.6	1.0	-1.0
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.5	0.4	0.1
Pavlov. Cond. magazine entry latency	3.8	4.9	6.1	2.0	2.1	-2.5
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	0.4	0.2	-0.7
Pavlov. Cond. index score	0.8	1.0	1.3	1.1	0.6	-1.1
Pavlov. Cond. latency score	0.7	0.9	1.6	1.3	0.5	-1.0
Pavlov. Cond. lever contacts	0.2	0.3	0.7	0.8	-0.2	-0.3
Pavlov. Cond. magazine entry number	1.2	1.4	1.9	-1.2	-1.1	1.4
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	-0.1	0.5	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	1.9	1.4	0.9	-1.4
Pavlov. Cond. response bias	1.6	2.0	2.6	1.3	1.2	-1.6
Pavlov. Cond. lever latency	0.5	0.7	0.9	-0.6	-0.9	0.9
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.6	0.7	-0.9
Pavlov. Cond. change in total contacts	0.4	0.6	0.9	0.6	0.9	-0.8
Pavlov. Cond. index score	0.6	0.8	1.1	0.6	1.0	-1.0
Pavlov. Cond. latency score	0.6	0.7	0.8	0.7	0.9	-0.9
Pavlov. Cond. lever contacts	0.5	0.7	1.0	0.4	1.0	-1.0
Pavlov. Cond. magazine entry number	0.7	0.9	1.1	-0.8	-0.9	1.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	-1.0	-0.4	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	1.0	0.7	1.0	-1.0
Pavlov. Cond. response bias	1.5	2.0	2.6	1.0	1.6	-1.6
Time in closed arm before self-admin	0.8	0.9	1.5	-0.1	-1.1	1.2
Time in closed arm after self-admin	0.0	0.0	0.0	0.0	0.2	-0.1
Time in open arm before self-admin	0.8	0.8	1.3	0.6	0.9	-1.1
Time in open arm after self-admin	0.8	0.9	1.0	-1.0	-0.9	0.9
Bone: periosteal estimation	0.3	0.6	1.0	-0.4	-1.0	0.8
Bone: periosteal perimeter	0.1	0.1	0.4	0.6	-0.1	-0.1
Bone: post-yield work	0.5	0.6	1.2	-1.1	-0.8	0.3
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.4	-0.0	-0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.5	-0.1	-0.1
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.1	0.3	0.2	-0.3
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	-0.0	0.5	-0.5
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	0.3	0.5	-0.5
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.3	0.1	-0.1
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.1	0.4	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.0	0.5	-0.3
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	-0.1	0.1
Progressive ratio	0.1	0.1	0.2	-0.5	-0.3	0.1
Food seeking constrained by brief footshock	0.4	0.5	0.9	0.9	0.4	-0.7
Seeking ratio, punishment vs. effort	0.3	0.4	0.7	0.8	0.4	-0.4
Retroperitoneal fat weight	0.2	0.6	0.9	-0.9	-0.6	0.7
Reaction time number correct	0.7	1.0	2.7	-1.6	-0.4	0.2
Reaction time mean minus median	0.7	0.9	1.3	0.6	1.1	-1.0
Reaction time mean minus median AUC	0.0	0.0	0.1	0.4	0.0	0.1
Reaction time num false alarms	0.3	0.5	1.3	-1.1	-0.3	-0.1
Reaction time num false alarms AUC	0.4	0.6	1.8	-1.3	-0.3	-0.1
Reaction time trials correct on left	0.7	1.0	2.7	-1.6	-0.4	0.2
Reaction time trials on left	0.7	0.9	2.6	-1.6	-0.4	0.3
Reaction time mean	0.0	0.0	0.1	0.1	-0.1	0.3
Reaction time mean AUC	0.1	0.1	0.2	-0.0	-0.2	0.5
Median of all reaction times	0.3	0.4	0.7	-0.3	-0.7	0.8
Reaction time omissions	0.3	0.4	0.7	0.8	0.6	-0.1
Reaction time false alarm rate	0.1	0.1	0.2	-0.4	-0.3	0.0
Reaction time premature initiation rate	1.0	1.4	2.0	0.8	1.4	-1.2
Reaction time premature initiations	0.7	1.0	1.7	0.0	1.3	-1.2
Std. dev. reaction times	0.2	0.2	0.3	0.4	0.6	-0.4
Reaction time trials completed	0.7	0.9	2.6	-1.6	-0.4	0.3
Reaction time trials AUC	0.7	1.0	2.9	-1.7	-0.4	0.2
Run reversals in cocaine runway, females	0.5	0.5	0.6	0.8	0.6	-0.7
Run reversals in cocaine runway, males	1.6	1.6	2.2	1.5	1.2	-1.0
Latency to leave start box in cocaine runway	0.7	0.7	1.9	1.4	0.5	0.1
Latency to leave start box in cocaine runway, F	0.7	0.8	1.5	0.6	-0.7	1.2
Latency to leave start box in cocaine runway, M	2.8	2.7	3.5	1.0	1.9	-1.9
Std. dev. time between licks in bursts	0.6	0.8	1.0	1.0	0.8	-0.9
Total sessions with >9 infusions	0.0	0.0	0.1	0.1	-0.3	0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.2	0.4	0.3	-0.3
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.2	-0.0	0.0
Short access day 1 total infusions	0.2	0.3	0.7	0.8	0.2	-0.2
Short access day 10 total infusions	0.1	0.2	0.3	0.0	0.4	-0.6
Short access total infusions	0.0	0.0	0.0	0.1	-0.1	0.0
Short access day 1 locomotion	1.0	1.0	1.6	1.3	0.9	-0.8
Short access day 10 total locomotion	3.5	4.0	4.6	1.7	2.1	-2.1
Short access total locomotion	0.8	0.8	1.0	1.0	0.8	-0.9
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.4	-0.3	0.2
Compulsive drug intake	1.4	1.5	1.9	-0.8	-1.4	1.4
One hour access (shock baseline)	0.2	0.3	0.5	-0.1	0.6	-0.7
Social response proportion	0.9	0.9	2.0	1.4	0.7	-0.5
Social responses	6.4	8.2	10.3	3.2	2.7	-2.7
Social time	0.6	0.7	1.2	-0.5	-0.9	1.1
Soleus weight	9.1	26.6	27.9	-5.3	-5.2	5.0
Bone: stiffness	2.7	4.3	5.6	-2.0	-2.4	1.9
Tibialis anterior weight	1.1	3.6	4.3	-2.1	-2.0	1.6
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.3	1.1	0.4	-0.4
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.4	-0.2	0.6	-0.6
Time to tail flick, test, before self-admin	0.3	0.2	0.7	0.8	0.2	-0.1
Time to tail flick, test, after self-admin	0.3	0.3	0.6	0.8	0.5	-0.4
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.5	-1.2	-0.2	0.2
Delta time to tail flick, test, before/after SA	0.3	0.2	0.4	0.0	0.6	-0.6
Tibia length	0.8	2.2	2.6	1.3	1.5	-1.6
Ambulatory time before self-admin	0.6	0.7	1.1	-0.5	-0.8	1.0
Ambulatory time after self-admin	0.2	0.2	0.4	0.7	0.4	-0.3
Bone: tissue strength	1.9	1.9	2.3	-1.1	-1.5	1.5
Total heroin consumption	2.0	2.3	2.5	1.6	1.5	-1.4
Bone: trabecular number	0.6	1.0	2.5	1.6	0.4	-0.4
Bone: trabecular spacing	0.9	1.2	3.4	-1.9	-0.1	-0.1
Bone: trabecular thickness	1.3	1.5	1.8	1.3	-1.0	1.4
Bone: trabecular tissue density	1.4	2.0	2.9	-1.7	-1.4	1.1
Water consumed over 24 hours	0.7	0.8	1.2	-0.7	-1.1	0.9
Number of responses in last shaping day	0.1	0.1	0.1	0.3	0.4	-0.3