Plekhg4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Plekhg4	0.9	0	0.0e+00	0.32	0.31	0.32	0.32	1.4e-35	4.2e-35	6.7e-36	4.7e-36
2	NAcc	gene expression	Plekhg4	0.03	0.03	8.5e-05	0.01	0.02	0	0.01	5.3e-03	1.3e-04	5.6e-02	2.7e-03
3	Adipose	alternative polyA	XM_063278645.1	0.05	0.04	1.8e-05	0.03	0.03	0.02	0.02	4.2e-04	1.9e-04	2.2e-03	1.5e-03
4	Adipose	alternative polyA	XM_063278642.1	0.05	0.04	3.6e-05	0.03	0.03	0.02	0.02	7.3e-04	3.3e-04	3.7e-03	2.6e-03
5	Adipose	alternative TSS	XM_039098213.2	0.06	0.05	2.1e-06	0.04	0.04	0.06	0.04	2.7e-05	2.8e-05	3.2e-07	2.8e-05
6	Adipose	alternative TSS	XM_039098213.2	0.06	0.05	1.2e-06	0.04	0.04	0.06	0.04	1.8e-05	1.9e-05	3.5e-07	2.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.1	0.2	0.3	0.2	-0.1	-0.0	0.0
Area under the delay curve	0.3	0.4	1.2	-0.2	0.1	0.1	-0.1	-1.0	-1.1
BMI with tail	0.0	0.1	0.3	0.3	0.3	0.2	-0.2	0.5	0.6
BMI without tail	0.0	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.0	-0.1
Body weight	0.2	1.1	2.2	1.5	1.2	1.2	-1.2	0.0	0.1
Weight adjusted by age	0.2	0.4	1.1	-0.1	0.1	0.1	-0.1	-1.0	-1.0
Bone surface	0.9	1.7	2.5	1.5	1.6	1.5	-1.5	-0.9	-0.8
Bone volume	0.7	1.3	1.9	1.4	1.4	1.3	-1.3	-0.6	-0.5
Breakpoint value in progressive ratio session	2.1	2.5	3.0	-1.7	-1.6	-1.7	1.7	1.3	1.4
Number of licking bursts	0.6	1.0	1.3	0.9	1.0	0.9	-0.9	-1.1	-1.1
Context. condit. distance diff. score	0.0	0.0	0.1	-0.4	-0.1	-0.1	0.1	0.1	-0.0
Locomotion velocity, session 1	0.1	0.1	0.1	0.2	0.2	0.3	-0.3	-0.2	-0.2
Locomotion distance, session 1	0.1	0.1	0.1	-0.2	-0.4	-0.2	0.2	0.3	0.2
Locomotion velocity, session 2	0.5	0.6	0.8	-0.7	-0.9	-0.8	0.8	0.7	0.6
Locomotion distance, session 2	0.1	0.1	0.1	-0.2	-0.4	-0.2	0.2	0.4	0.3
Locomotion velocity, session 3	0.3	0.3	0.5	-0.7	-0.5	-0.6	0.6	-0.3	-0.4
Locomotion distance, session 3	0.1	0.1	0.5	-0.3	-0.1	-0.0	0.0	-0.5	-0.7
Stereotopy head waving bouts, day 3	0.1	0.2	0.3	0.4	0.3	0.4	-0.4	-0.5	-0.5
Stereotopy head waving duration, day 3	0.3	0.4	0.8	0.9	0.7	0.7	-0.7	-0.3	-0.1
Locomotion velocity, session 7	0.1	0.1	0.2	-0.2	-0.1	-0.2	0.2	0.5	0.5
Locomotion distance, session 7	0.0	0.0	0.1	-0.4	-0.1	-0.2	0.2	-0.1	-0.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.2	0.4	0.3	-0.2	-0.6	-0.5
Stereotopy head waving duration, day 7	0.4	0.5	0.8	0.6	0.8	0.6	-0.6	-0.9	-0.8
Locomotion velocity, session 8	0.1	0.1	0.1	-0.3	-0.2	-0.4	0.4	0.3	0.4
Locomotion distance, session 8	0.2	0.4	0.8	-0.9	-0.6	-0.6	0.6	0.4	0.2
Degree of sensitization distance	0.0	0.0	0.0	0.0	0.1	0.0	-0.0	0.0	0.0
Degree of sensitization stereotypy	0.2	0.2	0.3	0.4	0.6	0.4	-0.4	-0.5	-0.4
Conditioned locomotion	1.6	1.9	2.6	1.6	1.6	1.6	-1.6	-0.7	-0.7
Cocaine response after cond. corrected	0.2	0.2	0.4	0.6	0.6	0.6	-0.5	-0.1	-0.1
Cocaine response after cond. not corrected	0.0	0.0	0.0	-0.0	0.1	0.0	-0.0	-0.0	0.0
Cocaine response before conditioning	0.8	0.9	1.6	-1.3	-1.2	-1.1	1.1	0.1	-0.1
Saline control response	3.4	4.5	7.4	2.7	2.4	2.5	-2.5	-0.8	-0.8
Bone: connectivity density	0.0	0.1	0.1	-0.4	-0.2	-0.3	0.4	-0.0	0.0
Bone: cortical apparent density	0.7	1.0	1.8	-1.4	-1.1	-1.2	1.3	0.1	0.2
Bone: cortical area	0.2	0.3	0.5	0.7	0.7	0.7	-0.7	0.0	0.1
Bone: cortical porosity	0.3	0.4	1.0	-0.4	-0.4	-0.3	0.3	1.0	0.8
Bone: cortical porosity	0.2	0.3	0.7	-0.4	-0.4	-0.3	0.3	0.8	0.7
Bone: cortical thickness	0.1	0.1	0.3	0.3	0.3	0.2	-0.2	0.4	0.5
Bone: cortical thickness	0.1	0.2	0.5	0.2	0.1	0.1	-0.1	0.6	0.7
Bone: cortical tissue density	0.8	1.1	1.9	-1.4	-1.1	-1.3	1.3	0.1	0.1
Condit. Reinf. active minus inactive responses	3.1	3.5	5.4	-2.3	-2.1	-2.1	2.1	1.1	0.9
Condit. Reinf. active-inactive response ratio	2.7	2.9	5.0	-2.2	-1.9	-1.9	1.9	1.0	0.7
Condit. Reinf. active responses	2.0	2.5	4.0	-2.0	-1.9	-1.8	1.8	0.8	0.6
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.4	-0.0	-0.0
Incentive salience index mean	1.7	2.1	3.0	-1.7	-1.6	-1.6	1.6	1.1	0.9
Condit. Reinf. lever presses	0.3	0.4	0.9	-0.4	-0.5	-0.5	0.5	1.0	0.9
Condit. Reinf. active minus inactive responses	0.6	0.8	1.1	1.0	1.1	1.1	-1.1	-0.5	-0.5
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.7	0.8	0.8	0.8	-0.8	-0.5	-0.4
Condit. Reinf. active responses	0.3	0.5	0.7	0.8	0.8	0.8	-0.8	-0.1	-0.2
Condit. Reinf. inactive responses	0.1	0.2	0.5	-0.3	-0.4	-0.3	0.3	0.7	0.5
Condit. Reinf. lever presses	2.1	2.9	3.3	-1.8	-1.8	-1.8	1.8	1.4	1.3
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	0.3	0.3	0.3	-0.3	0.3	0.2
Conditioned reinforcement - actives	0.5	0.8	1.2	-0.8	-1.0	-0.8	0.8	1.1	0.9
Conditioned reinforcement - inactives	0.0	0.1	0.2	-0.1	0.4	0.2	-0.1	-0.2	-0.2
Conditioned locomotion	0.4	0.6	1.0	0.7	1.0	0.8	-0.8	-0.4	-0.5
Patch foraging indifference point 0 sec	2.5	4.6	6.2	2.4	2.4	2.5	-2.5	-1.3	-1.2
Patch foraging indifference point AUC	1.5	2.2	2.8	1.7	1.7	1.7	-1.7	-1.0	-1.0
Delay disc. indifference point, 0s delay	0.5	0.5	0.9	-0.9	-0.9	-0.9	0.9	0.2	0.2
Delay disc. indifference point, 16s delay	0.3	0.4	0.6	0.5	0.4	0.6	-0.6	-0.7	-0.7
Delay disc. indifference point, 2s delay	0.4	0.4	1.0	-0.0	0.5	0.3	-0.3	-1.0	-1.0
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.1	0.1	0.2	-0.2	-0.1	-0.1
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	-0.8	-0.5	-0.6	0.6	-0.3	-0.3
Delay disc. indifference point, 8s delay	0.7	0.8	2.6	-0.2	0.1	0.1	-0.2	-1.4	-1.6
Indifference point function ln k	0.2	0.3	0.7	-0.9	-0.5	-0.6	0.6	0.3	0.2
Indifference point function log k	0.2	0.3	0.7	-0.9	-0.5	-0.6	0.6	0.3	0.2
Patch foraging total patch changes 0 sec	2.4	4.5	6.1	2.4	2.4	2.5	-2.5	-1.3	-1.1
Patch foraging total patch changes 12 sec	2.7	3.5	4.2	2.0	2.0	2.1	-2.1	-1.6	-1.5
Patch foraging total patch changes 18 sec	2.2	3.4	4.6	2.0	2.1	2.1	-2.1	-1.1	-1.1
Patch foraging total patch changes 24 sec	0.4	0.7	1.7	0.4	0.6	0.5	-0.5	-1.3	-1.3
Patch foraging total patch changes 6 sec	1.6	2.4	3.1	1.8	1.8	1.7	-1.7	-1.1	-1.1
Patch foraging time to switch 0 sec	0.7	1.4	1.9	-1.3	-1.4	-1.4	1.4	0.8	0.7
Patch foraging water rate 0 sec	1.1	2.3	3.7	1.9	1.7	1.8	-1.8	-0.7	-0.5
Patch foraging water rate 12 sec	0.2	0.4	0.8	0.3	0.5	0.5	-0.5	-0.9	-0.9
Patch foraging water rate 18 sec	0.4	0.6	1.7	0.1	0.5	0.3	-0.3	-1.2	-1.3
Patch foraging water rate 24 sec	0.1	0.1	0.1	0.2	0.2	0.2	-0.3	-0.4	-0.4
Patch foraging water rate 6 sec	0.6	0.8	1.2	0.8	1.1	1.0	-1.0	-0.8	-0.7
Seeking ratio, delayed vs. immediate footshock	2.2	2.6	3.5	1.6	1.9	1.8	-1.8	-1.2	-1.2
Distance traveled before self-admin	0.4	0.6	1.1	-0.1	1.0	0.4	-0.4	-1.1	-1.0
Distance traveled after self-admin	0.3	0.4	1.1	-0.0	0.3	0.2	-0.2	-1.0	-1.1
Extensor digitorum longus weight	0.6	2.2	2.7	-1.6	-1.6	-1.6	1.6	1.2	1.1
Bone: elastic displacement	1.5	1.8	2.1	1.5	1.4	1.4	-1.4	-1.2	-1.1
Bone: elastic work	0.5	0.6	0.9	0.9	0.8	0.8	-0.8	-0.8	-0.6
Bone: endosteal estimation	0.1	0.2	0.3	0.5	0.5	0.5	-0.6	-0.2	-0.3
Bone: endosteal perimeter	0.2	0.5	0.7	0.6	0.8	0.8	-0.8	-0.4	-0.6
Epididymis fat weight	2.0	6.7	8.5	2.5	2.9	2.9	-2.9	-2.1	-2.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	0.4	0.3	0.5	-0.5	-0.7	-0.8
Delta time in open arm before/after self-admin	0.2	0.2	0.6	-0.7	-0.1	-0.5	0.5	-0.4	-0.5
Diff in mean of infusions in LGA sessions	0.6	0.7	0.9	-0.9	-0.8	-0.9	0.9	0.7	0.8
Delay discount exponential model param	0.3	0.3	1.1	0.3	0.0	-0.0	0.0	0.9	1.0
Extinction: sum of active levers before priming	1.1	1.2	2.3	-0.7	-1.0	-0.9	0.9	1.4	1.5
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	0.0	0.2	-0.2	0.3	0.3
Bone: final force	0.8	1.3	1.4	-1.2	-1.2	-1.2	1.2	1.1	1.0
Bone: final moment	0.4	0.6	0.6	-0.8	-0.8	-0.8	0.8	0.8	0.7
Food consumed during 24 hour testing period	0.7	0.9	1.5	0.7	0.8	1.0	-1.0	-1.0	-1.2
Glucose	1.2	1.9	3.0	-1.7	-1.6	-1.7	1.7	0.3	0.3
Heart weight	0.0	0.0	0.1	-0.2	-0.1	-0.2	0.2	0.2	0.3
Delay discount hyperbolic model param	0.3	0.4	1.0	0.5	0.1	0.1	-0.1	0.9	1.0
Intermittent access intake day 1-15 change	0.7	1.5	2.4	-1.4	-1.5	-1.3	1.3	0.8	0.7
Intermittent access intake escalation	0.8	1.7	2.7	-1.5	-1.6	-1.4	1.4	0.7	0.6
Intermittent access intake escalation 2	0.6	0.7	1.1	-0.8	-1.1	-0.9	0.8	0.7	0.7
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.0	-0.1	0.0	-0.0	0.0	-0.0
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.5	-0.7	-0.3	-0.5	0.5	0.1	0.1
Intermitt. access escalation Index	0.5	0.8	1.7	0.6	0.5	0.6	-0.6	-1.3	-1.2
Intermittent access day 1 total infusions	0.0	0.1	0.2	0.1	-0.2	0.1	-0.1	0.5	0.4
Intermittent access day 15 total infusions	1.0	1.5	2.5	-1.3	-1.6	-1.2	1.2	1.1	0.9
Intermittent access terminal intake (last 3 days)	2.1	2.7	3.6	-1.6	-1.9	-1.6	1.6	1.7	1.5
Intermittent access total infusions	1.7	2.0	2.6	-1.2	-1.6	-1.3	1.2	1.6	1.5
Intermittent access day 1 locomotion	1.2	1.5	1.9	1.4	1.3	1.4	-1.4	-0.9	-1.0
Intermittent access day 15 total locomotion	0.1	0.3	0.4	0.5	0.6	0.6	-0.6	-0.4	-0.4
Intermittent access total locomotion	0.1	0.1	0.1	0.1	0.2	0.2	-0.2	0.3	0.4
Intermittent access standard deviation	0.1	0.2	0.3	0.5	0.5	0.5	-0.5	0.1	0.1
Left kidney weight	1.2	5.6	8.0	-2.8	-2.5	-2.7	2.7	1.5	1.3
Right kidney weight	1.3	5.7	7.9	-2.8	-2.6	-2.7	2.7	1.6	1.5
Cocaine induced anxiety	1.6	2.3	4.5	2.1	1.8	1.7	-1.7	-0.4	-0.1
Post-drug Anxiety	0.4	0.4	0.7	0.8	0.7	0.7	-0.7	-0.4	-0.3
Baseline Anxiety	0.9	1.1	2.1	-1.4	-1.2	-1.1	1.1	-0.4	-0.7
Tail length	0.0	0.1	0.2	0.4	0.1	0.3	-0.4	-0.2	-0.4
Length with tail	0.1	0.6	1.2	1.1	0.8	0.9	-0.9	-0.2	-0.2
Length without tail	0.4	1.2	2.2	1.5	1.3	1.3	-1.3	-0.2	-0.1
Times rat made contact with spout	1.8	2.0	2.3	1.5	1.4	1.5	-1.5	-1.3	-1.3
Lifetime Intake	1.2	1.5	2.2	-1.1	-1.5	-1.1	1.1	1.3	1.1
Liver weight, left	0.2	0.3	0.4	0.6	0.6	0.5	-0.5	-0.6	-0.5
Liver weight, right	0.4	0.7	1.3	1.2	0.9	0.9	-1.0	-0.3	-0.3
Locomotor activity	1.7	2.7	4.2	2.1	2.0	1.9	-1.9	-0.5	-0.4
Locomotor testing distance	1.4	2.5	4.3	2.1	1.9	1.9	-1.9	-0.4	-0.3
Locomotor testing rearing	0.1	0.3	0.4	0.6	0.6	0.5	-0.4	0.5	0.5
Locomotion in novel chamber	1.8	2.3	3.2	1.5	1.8	1.8	-1.8	-1.0	-0.9
Locomotion in novel chamber post-restriction	1.5	2.5	3.8	1.9	1.6	1.8	-1.8	-1.1	-0.9
Fecal boli incidents, locomotor time 1	1.1	1.5	3.2	1.8	1.0	1.3	-1.3	-0.9	-0.8
Change in fecal boli incidents, locomotor task	0.5	0.5	1.0	-1.0	-0.7	-0.8	0.8	0.3	0.2
Time >=10cm from walls, locomotor time 1	0.9	1.0	1.6	0.9	0.6	0.9	-0.9	-1.2	-1.3
Bouts of movement, locomotor time 1	0.2	0.2	0.5	0.6	0.1	0.2	-0.2	0.5	0.7
Total resting periods, locomotor time 1	0.1	0.1	0.4	0.3	-0.2	-0.1	0.1	0.5	0.6
Rest time, locomotor task time 1	0.2	0.2	0.3	-0.1	-0.6	-0.5	0.5	0.5	0.5
Distance moved, locomotor task time 1	0.1	0.2	0.3	0.3	0.5	0.5	-0.5	-0.4	-0.4
Vertical activity count, locomotor time 1	0.5	1.2	1.7	1.2	1.2	1.3	-1.3	-0.7	-0.6
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.6	-0.5	-0.7	-0.7	0.7	0.4	0.5
Bouts of movement, locomotor time 2	0.7	1.1	1.5	-0.8	-1.0	-1.0	1.0	1.2	1.2
Total resting periods, locomotor time 2	0.8	1.4	1.8	-1.0	-1.2	-1.2	1.2	1.3	1.3
Rest time, locomotor task time 2	0.4	0.6	0.9	-0.5	-0.9	-0.7	0.7	0.8	0.8
Distance moved, locomotor task time 2	0.3	0.4	0.9	0.5	0.9	0.6	-0.6	-0.6	-0.5
Vertical activity count, locomotor time 2	0.7	1.0	1.6	1.1	1.3	1.1	-1.1	-0.7	-0.6
Light reinforcement 1	1.7	4.3	6.2	2.2	2.5	2.4	-2.4	-1.3	-1.2
Light reinforcement 2	2.3	3.5	4.1	1.8	2.0	2.0	-2.0	-1.8	-1.7
Bone: marrow area	0.1	0.2	0.2	0.4	0.4	0.5	-0.5	-0.2	-0.3
Bone: maximum diameter	0.4	0.7	1.1	0.9	1.0	1.0	-1.0	-0.3	-0.3
Bone: maximum force	0.2	0.4	0.6	-0.7	-0.7	-0.7	0.7	0.5	0.5
Bone: maximum moment	0.0	0.1	0.1	-0.3	-0.2	-0.3	0.3	0.2	0.2
Mean time between licks in bursts	0.1	0.3	0.7	0.0	0.2	0.2	-0.2	-0.8	-0.9
Mean num. licks in bursts	0.0	0.0	0.0	0.2	0.0	0.1	-0.1	0.1	0.1
Cd content in liver	0.2	0.2	0.5	-0.4	-0.2	-0.4	0.4	0.7	0.7
Co content in liver	0.1	0.1	0.3	-0.1	-0.2	-0.2	0.2	0.6	0.6
Cu content in liver	0.6	0.7	1.0	-0.9	-1.0	-0.9	0.9	0.6	0.5
Fe content in liver	1.4	1.7	3.3	1.8	1.4	1.5	-1.5	-0.7	-0.5
K content in liver	0.1	0.0	0.1	-0.3	-0.3	-0.2	0.2	0.1	0.0
Mg content in liver	0.5	0.5	0.6	0.8	0.7	0.8	-0.8	-0.6	-0.6
Mn content in liver	0.6	0.7	0.9	0.8	0.9	0.8	-0.8	-0.9	-0.8
Na content in liver	0.1	0.2	0.5	-0.0	-0.1	-0.0	0.0	-0.7	-0.7
Rb content in liver	0.2	0.2	0.3	-0.4	-0.5	-0.4	0.4	0.6	0.5
Se content in liver	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.2	-0.1	-0.1
Sr content in liver	1.1	0.9	1.2	1.0	1.1	1.1	-1.1	-0.8	-0.8
Zn content in liver	1.3	1.4	1.8	-1.4	-1.3	-1.2	1.2	1.0	0.9
Bone: minimum diameter	0.1	0.2	0.3	0.5	0.5	0.5	-0.5	0.0	0.1
Time in familiar zone, hab. session 1	0.4	0.3	0.6	0.3	0.6	0.5	-0.5	-0.8	-0.8
Time in novel zone, hab. session 1	0.4	0.4	0.8	-0.2	-0.6	-0.5	0.5	0.8	0.9
Total zone transitions, hab. session 1	0.7	0.9	1.4	1.2	1.1	1.2	-1.2	-0.4	-0.4
Total locomotion distance, hab. session 1	0.8	1.2	1.9	1.4	1.2	1.3	-1.3	-0.2	-0.2
Locomotion velocity, hab. session 1	1.1	1.5	2.5	1.6	1.4	1.5	-1.5	-0.2	-0.2
Time in familiar zone, hab. session 2	0.7	0.7	0.9	0.8	0.9	0.9	-0.9	-0.8	-0.7
Time in novel zone, hab. session 2	3.7	3.7	5.1	-2.1	-2.3	-2.2	2.2	1.3	1.2
Total zone transitions, hab. session 2	1.5	1.9	3.6	1.9	1.6	1.6	-1.6	-0.3	-0.1
Total locomotion distance, hab. session 2	0.9	1.2	2.2	1.5	1.2	1.3	-1.3	-0.1	-0.0
Locomotion velocity, hab. session 2	0.9	1.2	2.2	1.5	1.2	1.3	-1.3	0.0	0.1
Novel to familiar place preference ratio	1.7	1.9	3.4	-1.8	-1.5	-1.7	1.7	0.2	0.2
Novelty place preference	2.8	3.0	5.0	-2.2	-1.9	-2.1	2.1	0.5	0.5
Time in novel zone, NPP test	2.5	2.7	4.6	-2.1	-1.8	-2.0	2.0	0.4	0.4
Total zone transitions, NPP test	1.4	2.0	3.3	1.8	1.6	1.7	-1.7	-0.5	-0.4
Total locomotion distance, NPP test	0.7	1.0	2.0	1.4	1.1	1.2	-1.2	-0.0	0.1
Locomotion velocity, NPP test	0.6	0.9	1.8	1.3	1.0	1.1	-1.1	0.1	0.2
Intraocular pressure	0.7	1.1	1.7	-0.9	-0.8	-0.9	0.9	1.3	1.2
Delta distance traveled before/after self-admin	0.3	0.3	0.5	-0.6	-0.7	-0.6	0.6	0.1	-0.0
Delta ambulatory time before/after self-admin	0.4	0.5	0.9	-0.8	-1.0	-0.8	0.8	0.3	0.1
Parametrial fat weight	5.3	12.6	19.0	4.4	4.0	4.0	-4.0	-2.2	-1.9
Pavlov. Cond. lever latency	0.2	0.2	0.5	0.1	0.3	0.3	-0.3	-0.7	-0.7
Pavlov. Cond. magazine entry latency	0.4	0.6	0.8	-0.6	-0.8	-0.7	0.7	0.9	0.8
Pavlov. Cond. change in total contacts	0.7	0.7	1.1	-1.1	-0.9	-1.0	1.0	0.5	0.4
Pavlov. Cond. index score	0.4	0.5	0.9	-0.5	-0.7	-0.6	0.6	0.9	0.8
Pavlov. Cond. latency score	0.3	0.4	0.8	-0.4	-0.6	-0.5	0.5	0.9	0.8
Pavlov. Cond. lever contacts	0.6	0.8	1.0	-0.7	-0.8	-0.8	0.8	1.0	1.0
Pavlov. Cond. magazine entry number	0.4	0.5	0.7	0.7	0.8	0.7	-0.7	-0.7	-0.5
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	0.4	0.5	0.6	-0.6	-0.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	-0.6	-0.7	-0.7	0.7	0.9	0.8
Pavlov. Cond. response bias	0.3	0.4	0.6	-0.4	-0.6	-0.5	0.5	0.8	0.7
Pavlov. Cond. lever latency	1.0	1.4	1.8	1.4	1.3	1.3	-1.3	-0.8	-0.8
Pavlov. Cond. magazine entry latency	3.1	3.7	4.4	-2.1	-2.1	-2.1	2.1	1.7	1.6
Pavlov. Cond. change in total contacts	1.5	2.4	3.2	-1.8	-1.6	-1.7	1.7	1.2	1.1
Pavlov. Cond. index score	2.9	3.9	4.7	-2.2	-2.1	-2.1	2.1	1.6	1.5
Pavlov. Cond. latency score	2.9	3.9	4.8	-2.2	-2.1	-2.1	2.1	1.6	1.5
Pavlov. Cond. lever contacts	1.3	1.7	2.2	-1.5	-1.5	-1.4	1.4	1.0	1.0
Pavlov. Cond. magazine entry number	4.8	5.9	7.4	2.7	2.6	2.6	-2.6	-2.0	-1.8
Pavlov. Cond. intertrial magazine entries	3.5	5.3	7.9	2.8	2.6	2.7	-2.7	-1.1	-1.0
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.2	5.4	-2.3	-2.3	-2.2	2.2	1.6	1.5
Pavlov. Cond. response bias	2.5	3.4	4.3	-2.1	-2.0	-2.0	2.0	1.4	1.4
Time in closed arm before self-admin	2.1	2.7	4.9	2.2	2.0	1.9	-1.9	-0.0	0.1
Time in closed arm after self-admin	2.2	2.3	3.4	1.8	1.8	1.7	-1.7	-0.9	-0.7
Time in open arm before self-admin	1.0	1.1	2.0	-1.4	-1.3	-1.2	1.2	0.2	0.0
Time in open arm after self-admin	0.6	0.7	1.4	-1.2	-0.8	-0.9	0.9	-0.2	-0.4
Bone: periosteal estimation	0.2	0.4	0.6	0.8	0.8	0.8	-0.8	-0.2	-0.2
Bone: periosteal perimeter	0.6	1.0	1.4	1.1	1.2	1.2	-1.2	-0.4	-0.4
Bone: post-yield work	0.5	0.7	0.8	0.7	0.9	0.8	-0.8	-0.9	-0.9
Progressive ratio test 1 active lever presses	1.8	2.2	3.4	-1.7	-1.8	-1.5	1.5	1.2	1.0
Progressive ratio test 1 breakpoint	1.6	1.9	2.9	-1.6	-1.7	-1.4	1.4	1.2	0.9
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.2	-0.3	-0.1	0.1	0.0	-0.1
Progressive ratio test 2 active lever presses	1.1	1.3	2.4	-1.1	-1.6	-1.1	1.1	1.1	0.8
Progressive ratio test 2 breakpoint	1.2	1.4	2.5	-1.2	-1.6	-1.2	1.1	1.1	0.9
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	-0.3	-0.4	-0.3	0.3	0.3	0.2
Incentive Sensitization - Responses	0.4	0.6	1.1	-0.4	-0.9	-0.5	0.5	1.0	1.0
Incentive Sensitization - Breakpoint	0.6	0.7	1.3	-0.4	-1.0	-0.6	0.6	1.1	1.1
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.7	-0.8	-0.5	-0.7	0.7	0.6	0.6
Progressive ratio	0.1	0.1	0.4	-0.6	0.0	-0.4	0.4	0.0	0.1
Food seeking constrained by brief footshock	1.2	1.5	2.3	-1.5	-1.4	-1.4	1.5	0.6	0.6
Seeking ratio, punishment vs. effort	0.2	0.3	0.8	-0.7	-0.9	-0.7	0.6	0.0	-0.2
Retroperitoneal fat weight	5.4	22.9	29.5	5.3	5.4	5.3	-5.3	-3.5	-3.3
Reaction time number correct	1.0	1.9	2.7	-1.1	-1.4	-1.3	1.3	1.6	1.6
Reaction time mean minus median	0.9	2.2	2.7	-1.5	-1.2	-1.5	1.5	1.6	1.6
Reaction time mean minus median AUC	0.8	2.1	3.1	-1.3	-1.1	-1.3	1.3	1.8	1.7
Reaction time num false alarms	0.1	0.1	0.2	-0.5	-0.3	-0.3	0.3	0.1	0.1
Reaction time num false alarms AUC	0.0	0.0	0.0	0.1	0.1	0.2	-0.2	0.1	0.1
Reaction time trials correct on left	1.0	1.9	2.7	-1.1	-1.4	-1.3	1.3	1.6	1.6
Reaction time trials on left	1.1	2.0	2.8	-1.1	-1.4	-1.3	1.3	1.7	1.6
Reaction time mean	0.2	0.4	0.7	-0.8	-0.2	-0.7	0.7	0.5	0.6
Reaction time mean AUC	0.5	0.8	1.1	-1.0	-0.5	-1.0	1.0	0.8	0.9
Median of all reaction times	0.1	0.1	0.2	-0.5	0.2	-0.3	0.3	0.0	0.1
Reaction time omissions	0.1	0.2	0.4	0.6	0.4	0.5	-0.5	-0.1	-0.2
Reaction time false alarm rate	0.4	0.5	0.6	0.6	0.8	0.7	-0.7	-0.6	-0.7
Reaction time premature initiation rate	1.1	1.5	2.1	-1.4	-1.4	-1.4	1.4	0.8	0.8
Reaction time premature initiations	2.1	3.7	4.5	-2.0	-2.1	-2.1	2.1	1.6	1.6
Std. dev. reaction times	0.6	1.1	1.8	-0.9	-0.6	-0.9	1.0	1.3	1.3
Reaction time trials completed	1.1	2.0	2.8	-1.1	-1.4	-1.3	1.3	1.7	1.6
Reaction time trials AUC	1.0	2.0	2.6	-1.2	-1.5	-1.3	1.3	1.6	1.6
Run reversals in cocaine runway, females	1.5	1.5	2.2	1.3	1.4	1.5	-1.5	-0.7	-0.8
Run reversals in cocaine runway, males	0.6	0.6	1.2	1.1	0.7	0.9	-0.9	-0.4	-0.4
Latency to leave start box in cocaine runway	0.3	0.3	0.4	-0.6	-0.5	-0.7	0.7	0.4	0.4
Latency to leave start box in cocaine runway, F	0.9	1.0	1.7	-1.1	-1.3	-1.2	1.2	0.5	0.3
Latency to leave start box in cocaine runway, M	0.4	0.4	1.0	0.6	1.0	0.6	-0.6	0.2	0.4
Std. dev. time between licks in bursts	1.7	2.3	3.0	1.7	1.7	1.7	-1.7	-1.1	-1.1
Total sessions with >9 infusions	0.7	0.9	1.6	-1.0	-1.3	-0.9	0.9	0.8	0.6
Short access day 1 total inactive lever presses	0.0	0.1	0.2	0.1	-0.0	-0.0	0.0	0.3	0.4
Short access day 10 total inactive lever presses	0.1	0.3	0.3	0.5	0.5	0.5	-0.5	-0.5	-0.5
Short access day 1 total infusions	0.1	0.1	0.3	-0.2	-0.6	-0.2	0.2	0.3	0.1
Short access day 10 total infusions	0.2	0.3	0.6	-0.2	-0.6	-0.3	0.2	0.8	0.7
Short access total infusions	0.9	1.2	2.2	-1.1	-1.5	-1.1	1.1	0.9	0.7
Short access day 1 locomotion	0.1	0.1	0.2	-0.1	-0.5	-0.2	0.2	0.3	0.2
Short access day 10 total locomotion	1.1	2.0	2.8	1.5	1.7	1.6	-1.6	-1.0	-0.9
Short access total locomotion	0.2	0.2	0.3	0.5	0.6	0.6	-0.6	-0.1	-0.1
One hour access (0.3 mA shock)	0.8	1.0	1.7	-0.6	-1.1	-0.8	0.8	1.3	1.1
Compulsive drug intake	0.1	0.1	0.3	0.3	0.4	0.3	-0.3	-0.5	-0.5
One hour access (shock baseline)	0.9	1.3	2.5	-0.6	-1.2	-0.8	0.8	1.6	1.5
Social response proportion	0.2	0.2	0.5	-0.5	-0.7	-0.5	0.5	0.1	-0.2
Social responses	0.0	0.0	0.1	0.2	0.0	0.2	-0.2	-0.1	-0.2
Social time	0.0	0.1	0.2	0.1	0.0	0.2	-0.2	-0.2	-0.5
Soleus weight	0.2	0.5	0.6	0.8	0.8	0.7	-0.7	-0.6	-0.6
Bone: stiffness	2.6	4.3	5.8	-2.4	-2.2	-2.3	2.3	1.6	1.4
Tibialis anterior weight	0.2	0.6	0.9	-0.6	-0.8	-0.7	0.7	0.9	0.8
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	-0.4	-0.7	-0.5	0.5	0.0	-0.1
Time to tail flick, vehicle, after self-admin	0.9	1.2	2.4	1.5	1.0	1.3	-1.3	0.4	0.6
Time to tail flick, test, before self-admin	2.8	2.9	5.7	2.4	1.8	2.0	-2.0	-0.6	-0.5
Time to tail flick, test, after self-admin	0.3	0.3	0.7	0.8	0.4	0.6	-0.6	-0.2	-0.3
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	2.5	1.6	0.9	1.1	-1.1	1.1	1.3
Delta time to tail flick, test, before/after SA	0.6	0.7	1.2	-1.1	-1.0	-0.9	0.9	-0.0	-0.2
Tibia length	0.1	0.3	0.9	0.0	-0.3	-0.3	0.3	0.8	1.0
Ambulatory time before self-admin	0.7	1.1	1.9	0.6	1.4	0.9	-0.9	-1.2	-1.1
Ambulatory time after self-admin	0.9	1.1	2.9	0.2	0.7	0.5	-0.5	-1.7	-1.7
Bone: tissue strength	0.4	0.4	0.6	-0.7	-0.5	-0.5	0.5	-0.8	-0.8
Total heroin consumption	1.2	1.4	1.5	-1.2	-1.2	-1.2	1.2	1.2	1.2
Bone: trabecular number	0.1	0.2	0.4	0.6	0.6	0.5	-0.5	-0.3	-0.1
Bone: trabecular spacing	0.1	0.1	0.2	0.4	0.3	0.4	-0.4	-0.1	-0.1
Bone: trabecular thickness	0.6	0.8	1.0	-0.8	-0.9	-1.0	1.0	0.8	0.8
Bone: trabecular tissue density	0.6	0.9	1.1	-1.1	-1.0	-1.1	1.1	0.7	0.7
Water consumed over 24 hours	0.5	0.6	0.9	0.7	0.7	0.8	-0.8	-0.8	-0.9
Number of responses in last shaping day	0.7	0.8	1.8	-1.3	-0.8	-1.0	1.1	0.5	0.3