Hub : Genes

Plcb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc isoform ratio NM_053478.2 0.14 0.08 7.6e-03 0.01 0.02 0.01 0 9.3e-03 1.2e-03 3.4e-03 6.1e-02
2 NAcc alternative polyA XM_063284733.1 0.27 0.1 6.2e-09 0.05 0.07 0.06 0.05 1.2e-07 1.5e-10 1.0e-09 7.3e-08
3 LHb isoform ratio XM_063284735.1 0.17 0.1 9.6e-03 0.09 0.08 0.06 0.1 4.5e-03 5.1e-03 2.0e-02 2.4e-03
4 PL alternative TSS XM_063284734.1 0.03 0.02 1.9e-03 0.01 0.02 0.01 0.02 3.1e-02 9.5e-04 7.1e-03 3.9e-03
5 Adipose mRNA stability Plcb2 0.08 0.05 4.3e-06 0.05 0.04 0.04 0.05 2.9e-06 1.9e-05 1.2e-05 7.7e-06
6 NAcc alternative polyA XM_063284733.1 0.16 0.07 3.8e-09 0.05 0.06 0.05 0.06 4.7e-08 2.1e-09 1.2e-08 7.4e-09
7 PL gene expression Plcb2 0.07 0.04 5.5e-06 0.04 0.04 0.03 0.04 3.7e-05 2.0e-05 4.7e-04 8.2e-05
8 Liver isoform ratio NM_053478.2 0.03 0.02 6.9e-03 0 -0 0.02 -0 1.4e-01 8.9e-01 5.9e-03 4.4e-01
9 OFC gene expression Plcb2 0.44 0.17 1.4e-04 0.16 0.12 0.14 0.13 1.5e-04 7.4e-04 2.9e-04 6.6e-04
10 PL isoform ratio XM_063284735.1 0.05 0.03 4.6e-03 0.01 0.01 0.01 0.01 1.5e-02 3.6e-02 4.5e-02 2.9e-02
11 IC gene expression Plcb2 0.25 0.13 4.0e-04 0.09 0.06 0.05 0.07 1.0e-04 1.8e-03 4.2e-03 7.5e-04
12 Brain alternative polyA XM_063284733.1 0.07 0.04 3.2e-04 0.03 0.04 0.03 0.03 1.5e-03 1.5e-04 3.9e-04 1.3e-03
13 Brain alternative polyA NM_053478.2 0.06 0.04 7.6e-04 0 0.02 0.02 0.01 1.0e-01 4.8e-03 8.3e-03 3.3e-02
14 NAcc isoform ratio XM_063284735.1 0.03 0.02 5.3e-03 0 0.01 0 0.01 4.4e-02 7.6e-03 1.8e-01 1.5e-02
15 Brain alternative polyA XM_063284733.1 0.06 0.04 4.6e-04 0 0.02 0.02 0.01 1.2e-01 2.2e-03 8.1e-03 1.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.20.42.1-0.10.20.90.4-1.30.1-0.71.50.30.30.20.2-0.2-0.10.2
Area under the delay curve3.13.77.3-0.61.42.20.9-0.12.11.0-1.52.12.02.02.7-2.62.42.6
BMI with tail1.34.421.40.21.04.63.5-2.91.6-2.6-1.40.50.50.61.5-2.20.61.9
BMI without tail1.75.120.8-1.92.14.63.2-4.11.7-3.2-0.3-0.10.80.91.0-1.60.01.2
Body weight1.45.924.3-0.71.94.94.1-3.42.2-2.9-1.50.80.60.81.8-2.60.72.2
Weight adjusted by age0.50.82.30.10.81.51.3-0.01.1-0.2-1.00.90.50.40.9-1.20.71.2
Bone surface0.71.44.71.5-1.20.90.7-1.7-0.9-1.62.2-0.8-0.8-1.0-0.70.5-1.1-0.6
Bone volume0.81.54.32.1-1.61.20.9-1.7-1.0-1.61.7-0.7-0.8-1.0-0.60.3-1.0-0.4
Breakpoint value in progressive ratio session0.80.95.12.3-2.00.2-0.5-0.6-1.4-0.30.0-0.1-0.6-0.4-0.60.6-0.7-0.6
Number of licking bursts0.81.34.22.0-2.1-0.5-0.9-0.6-1.6-0.50.6-0.3-0.9-0.6-1.01.2-1.0-1.1
Context. condit. distance diff. score0.91.14.0-0.0-0.31.10.5-2.0-0.6-1.91.0-1.0-0.4-0.7-0.80.8-1.2-0.9
Locomotion velocity, session 12.02.16.1-1.61.2-2.3-1.82.00.72.50.91.51.21.30.7-0.21.20.4
Locomotion distance, session 11.62.06.1-2.51.8-2.0-1.61.30.92.00.51.41.31.30.6-0.11.10.2
Locomotion velocity, session 22.22.55.4-2.12.00.4-0.4-0.31.71.20.22.32.12.11.8-1.41.71.5
Locomotion distance, session 20.71.03.7-1.91.1-1.7-1.60.40.21.11.10.90.90.8-0.00.50.3-0.4
Locomotion velocity, session 30.60.73.81.9-1.30.4-0.40.3-0.20.7-0.80.90.60.41.0-0.80.80.9
Locomotion distance, session 31.82.09.03.0-2.70.3-0.5-1.4-1.9-1.11.0-0.3-0.9-0.9-0.91.0-1.2-1.0
Stereotopy head waving bouts, day 31.41.75.50.10.82.31.8-0.41.3-0.3-1.30.20.70.51.6-1.91.21.8
Stereotopy head waving duration, day 32.53.05.9-0.81.52.31.4-0.12.00.4-1.71.21.61.52.3-2.42.02.4
Locomotion velocity, session 70.20.21.30.3-0.40.60.0-1.2-0.4-0.80.8-0.10.0-0.1-0.20.2-0.4-0.3
Locomotion distance, session 70.81.12.0-0.2-0.5-0.4-0.3-1.2-1.0-1.21.3-1.1-0.7-0.8-1.41.4-1.4-1.4
Stereotopy head waving bouts, day 70.40.43.01.7-1.00.30.40.7-0.30.20.2-0.4-0.4-0.60.2-0.40.20.5
Stereotopy head waving duration, day 70.70.85.52.3-1.30.80.90.7-0.4-0.1-0.2-0.6-0.7-0.80.2-0.60.10.6
Locomotion velocity, session 81.31.63.2-1.81.71.20.2-0.81.50.20.41.31.71.61.5-1.21.11.2
Locomotion distance, session 80.50.83.0-1.70.8-0.1-0.6-1.5-0.1-0.71.60.00.50.2-0.50.8-0.6-0.8
Degree of sensitization distance0.50.51.7-1.30.8-0.70.30.60.0-0.2-0.1-1.3-0.7-0.7-0.90.6-0.6-0.7
Degree of sensitization stereotypy1.01.13.92.0-1.50.00.50.4-1.1-0.50.9-1.3-1.3-1.4-0.80.5-0.8-0.5
Conditioned locomotion0.50.62.5-0.80.61.30.7-1.60.2-1.20.9-0.20.30.1-0.0-0.0-0.4-0.1
Cocaine response after cond. corrected1.11.46.52.5-2.5-0.8-1.70.5-1.50.40.60.00.0-0.1-0.30.8-0.4-0.6
Cocaine response after cond. not corrected0.91.03.81.6-1.8-1.2-2.00.8-1.01.00.40.50.40.30.00.60.0-0.5
Cocaine response before conditioning1.31.67.1-2.72.3-0.8-0.30.71.41.2-0.11.21.01.10.8-0.61.10.6
Saline control response1.01.34.9-0.91.41.72.2-0.31.2-0.8-1.9-0.6-0.2-0.40.6-1.20.51.1
Bone: connectivity density0.20.31.0-0.81.00.50.9-0.10.7-0.20.8-0.00.1-0.00.3-0.60.30.5
Bone: cortical apparent density3.04.110.03.2-2.9-0.7-0.0-0.4-2.5-1.40.4-2.1-2.5-2.4-2.31.9-2.2-1.9
Bone: cortical area0.50.73.30.8-0.11.81.3-1.40.3-1.00.20.3-0.0-0.00.6-0.90.20.8
Bone: cortical porosity2.83.06.7-2.61.7-1.2-2.10.61.32.10.42.42.42.41.5-0.61.60.7
Bone: cortical porosity2.02.24.7-2.11.6-0.2-1.20.11.41.50.02.22.12.11.6-0.91.51.0
Bone: cortical thickness0.50.82.0-0.30.81.40.8-1.00.9-0.3-0.61.00.70.71.1-1.10.81.1
Bone: cortical thickness1.21.47.72.8-2.40.1-0.6-0.7-1.6-0.60.1-0.3-0.7-0.7-0.60.8-0.9-0.7
Bone: cortical tissue density2.93.910.43.2-2.9-0.6-0.0-0.3-2.5-1.30.2-2.1-2.4-2.3-2.21.8-2.1-1.8
Condit. Reinf. active minus inactive responses0.60.72.40.5-0.1-0.31.20.5-0.3-0.50.5-1.3-1.5-1.6-0.90.3-0.7-0.4
Condit. Reinf. active-inactive response ratio0.40.52.20.9-0.21.01.5-0.10.1-0.80.3-0.7-0.9-0.8-0.1-0.4-0.20.3
Condit. Reinf. active responses1.21.54.70.4-0.2-0.91.00.8-0.8-0.60.5-2.0-2.2-2.1-1.71.0-1.2-1.0
Condit. Reinf. inactive responses1.31.63.60.4-0.7-1.5-0.10.4-1.3-0.40.5-1.6-1.8-1.7-1.91.5-1.5-1.5
Incentive salience index mean0.60.72.0-0.40.6-1.20.71.1-0.10.10.1-1.0-1.4-1.3-1.00.5-0.5-0.5
Condit. Reinf. lever presses0.50.72.6-1.31.2-1.60.31.30.30.6-0.3-0.5-0.9-0.8-0.80.4-0.2-0.4
Condit. Reinf. active minus inactive responses1.01.33.30.3-0.20.81.6-0.7-0.4-1.70.2-1.8-1.5-1.8-1.20.6-1.2-0.7
Condit. Reinf. active-inactive response ratio0.91.12.40.5-0.40.71.3-0.7-0.5-1.50.4-1.6-1.4-1.5-1.10.6-1.2-0.7
Condit. Reinf. active responses1.31.84.90.6-0.11.22.2-1.0-0.4-2.0-0.2-2.0-1.8-2.1-1.20.3-1.2-0.5
Condit. Reinf. inactive responses0.60.84.00.50.31.22.0-0.40.2-0.9-1.0-1.0-1.2-1.0-0.2-0.6-0.20.5
Condit. Reinf. lever presses1.01.46.71.00.21.52.6-0.00.4-1.0-2.0-1.1-1.3-1.30.0-1.0-0.00.8
Condit. Reinf. lever reinforcers received1.11.65.40.20.31.12.3-0.7-0.1-1.7-0.6-1.9-1.7-2.0-1.10.2-1.0-0.3
Conditioned reinforcement - actives0.40.71.3-0.90.8-0.2-0.61.10.81.10.61.11.11.10.7-0.50.80.5
Conditioned reinforcement - inactives0.20.31.9-0.3-0.20.3-0.4-0.8-0.4-0.51.40.00.20.3-0.30.5-0.4-0.5
Conditioned locomotion1.92.54.1-1.31.90.40.42.02.01.6-1.11.71.41.41.8-1.82.01.9
Patch foraging indifference point 0 sec2.85.116.4-0.62.22.52.90.72.60.5-4.01.00.90.72.4-3.22.33.1
Patch foraging indifference point AUC0.60.92.91.7-1.4-1.3-1.11.4-0.90.80.20.5-0.4-0.4-0.60.7-0.3-0.6
Delay disc. indifference point, 0s delay1.61.73.8-0.31.20.81.01.01.61.2-1.41.00.90.91.7-1.91.81.9
Delay disc. indifference point, 16s delay1.71.94.51.2-0.21.1-0.00.40.91.1-1.32.11.41.42.0-1.71.71.8
Delay disc. indifference point, 2s delay0.40.51.9-0.50.81.41.3-0.80.5-0.9-0.3-0.4-0.2-0.20.2-0.5-0.00.4
Delay disc. indifference point, 24s delay0.91.03.0-1.00.9-0.7-0.61.40.91.7-0.40.81.01.01.0-0.81.30.9
Delay disc. indifference point, 4s delay2.22.33.9-2.02.01.10.3-0.11.81.0-0.21.51.91.91.9-1.71.81.7
Delay disc. indifference point, 8s delay3.94.510.20.40.93.21.6-0.62.10.5-2.12.11.81.83.0-3.12.43.1
Indifference point function ln k0.71.26.0-1.20.92.11.0-2.50.6-1.40.0-0.10.60.60.5-0.6-0.00.4
Indifference point function log k0.71.26.0-1.20.92.11.0-2.50.6-1.40.0-0.10.60.60.5-0.6-0.00.4
Patch foraging total patch changes 0 sec2.24.115.20.21.52.42.80.62.20.3-3.90.90.50.42.1-2.81.92.8
Patch foraging total patch changes 12 sec0.70.96.00.40.60.41.01.30.80.5-2.50.7-0.2-0.30.6-0.90.70.9
Patch foraging total patch changes 18 sec0.30.42.60.8-0.2-0.20.11.40.30.6-1.60.6-0.2-0.20.2-0.30.30.3
Patch foraging total patch changes 24 sec1.12.03.5-0.41.31.51.30.51.80.4-1.91.41.11.01.7-1.91.51.8
Patch foraging total patch changes 6 sec0.40.62.60.60.20.51.00.90.60.4-1.60.4-0.1-0.00.6-1.00.71.0
Patch foraging time to switch 0 sec0.20.52.5-0.30.6-0.40.81.60.50.5-1.2-0.6-0.5-0.8-0.1-0.30.30.3
Patch foraging water rate 0 sec0.81.75.42.3-2.01.30.7-1.8-1.3-1.90.7-0.9-1.0-0.8-0.80.6-1.3-0.7
Patch foraging water rate 12 sec1.22.57.91.6-2.2-0.0-1.0-2.0-2.0-1.32.8-0.8-0.6-0.5-1.31.6-1.6-1.6
Patch foraging water rate 18 sec0.30.42.90.4-0.70.8-0.4-1.7-0.5-0.30.60.30.50.70.3-0.10.00.1
Patch foraging water rate 24 sec3.24.610.03.2-3.00.80.5-2.6-2.6-2.51.6-2.1-2.1-1.9-1.91.5-2.3-1.6
Patch foraging water rate 6 sec3.14.511.42.9-3.4-1.0-1.3-1.4-3.0-1.32.0-1.4-1.7-1.5-2.22.4-2.3-2.3
Seeking ratio, delayed vs. immediate footshock0.91.12.2-0.3-0.40.40.0-1.2-0.9-1.41.1-1.0-0.8-0.8-1.41.3-1.5-1.4
Distance traveled before self-admin0.40.51.4-0.50.51.20.3-0.80.6-0.10.50.90.91.20.7-0.70.50.6
Distance traveled after self-admin0.50.62.81.7-1.30.50.3-0.5-0.8-0.71.6-0.0-0.5-0.3-0.40.3-0.6-0.3
Extensor digitorum longus weight0.10.41.71.3-0.81.20.3-0.7-0.1-0.4-0.30.50.30.30.7-0.60.30.6
Bone: elastic displacement0.30.40.8-0.10.50.20.30.40.60.6-0.50.70.50.50.8-0.80.80.9
Bone: elastic work0.50.62.11.3-0.31.41.4-0.30.3-0.5-0.70.0-0.3-0.20.6-1.00.40.9
Bone: endosteal estimation0.51.15.21.0-1.30.0-0.4-1.1-1.1-1.02.3-0.7-0.5-0.6-0.91.0-1.1-1.0
Bone: endosteal perimeter0.30.77.00.6-0.7-0.1-0.1-0.6-0.6-0.62.6-0.5-0.4-0.4-0.50.5-0.6-0.6
Epididymis fat weight0.62.24.4-2.11.90.7-0.0-0.61.60.6-0.01.82.12.11.7-1.41.51.4
Delta time in closed arm before/after self-admin0.90.93.9-1.10.2-0.3-0.3-0.8-0.6-0.72.0-1.2-0.3-0.5-1.01.1-1.0-1.1
Delta time in open arm before/after self-admin1.71.74.01.7-1.70.80.2-2.0-1.3-2.01.6-0.5-0.7-0.6-1.11.0-1.5-1.1
Diff in mean of infusions in LGA sessions0.20.31.9-1.00.7-0.20.70.30.10.00.2-1.4-0.4-0.3-0.3-0.0-0.00.0
Delay discount exponential model param2.83.16.01.0-1.5-1.9-0.60.1-2.0-1.01.1-1.9-2.0-2.0-2.42.3-2.2-2.3
Extinction: sum of active levers before priming0.30.41.7-0.20.0-0.5-0.81.00.21.30.20.40.60.60.5-0.30.70.4
Active lever presses in extinction session 61.01.03.0-0.50.6-0.3-0.81.00.81.3-0.61.71.31.41.1-0.71.10.8
Bone: final force0.81.34.01.1-0.71.31.2-2.0-0.7-1.90.9-0.8-1.2-1.1-0.80.4-1.1-0.5
Bone: final moment0.81.33.81.3-0.91.41.2-1.9-0.8-1.90.8-0.9-1.2-1.1-0.80.4-1.1-0.5
Food consumed during 24 hour testing period0.30.41.10.1-0.6-0.8-1.0-0.5-0.7-0.10.70.3-0.0-0.1-0.60.9-0.6-0.9
Glucose0.50.84.80.7-0.61.50.6-2.2-0.5-1.50.5-0.1-0.2-0.3-0.20.2-0.7-0.2
Heart weight0.91.35.5-1.21.32.31.4-1.71.2-1.3-0.30.80.70.60.7-0.80.20.7
Delay discount hyperbolic model param2.42.64.91.1-1.5-1.9-0.80.2-1.9-0.71.0-1.6-1.8-1.8-2.22.1-1.9-2.1
Intermittent access intake day 1-15 change1.22.48.93.0-2.50.5-0.7-1.9-1.7-1.61.71.0-0.6-0.6-1.01.2-1.5-1.2
Intermittent access intake escalation1.22.411.43.4-2.60.9-0.3-1.9-1.6-1.71.41.0-0.7-0.7-0.80.9-1.4-1.0
Intermittent access intake escalation 22.02.25.72.3-2.4-0.3-1.9-1.7-1.6-0.72.41.50.20.3-0.71.3-1.1-1.3
Intermitt. access day 1 inactive lever presses0.62.416.1-4.03.10.91.3-1.01.6-0.40.5-1.20.70.70.5-0.80.60.7
Intermitt. access day 15 inactive lever presses0.30.63.8-0.70.20.30.1-1.1-0.3-1.01.9-0.5-0.1-0.0-0.60.6-0.7-0.7
Intermitt. access escalation Index1.01.53.11.6-0.90.81.7-0.8-0.8-1.5-0.2-1.7-1.7-1.8-1.00.3-1.1-0.4
Intermittent access day 1 total infusions0.40.61.1-0.60.8-0.10.30.90.90.90.00.50.70.70.9-1.01.11.0
Intermittent access day 15 total infusions0.40.52.21.5-0.90.70.3-0.8-0.4-0.91.50.6-0.2-0.2-0.10.1-0.5-0.1
Intermittent access terminal intake (last 3 days)0.81.14.71.8-1.50.2-0.4-1.4-1.0-0.92.20.7-0.1-0.1-0.40.5-0.7-0.5
Intermittent access total infusions0.10.21.20.7-0.40.20.0-0.2-0.0-0.21.10.60.10.20.2-0.10.00.1
Intermittent access day 1 locomotion2.12.74.7-1.82.20.90.90.92.21.1-0.51.31.61.62.0-2.12.02.1
Intermittent access day 15 total locomotion0.30.53.80.4-0.40.7-0.1-1.2-0.2-0.91.90.70.30.3-0.10.2-0.4-0.3
Intermittent access total locomotion0.50.61.7-0.30.60.40.10.30.90.41.11.30.80.90.9-0.80.80.8
Intermittent access standard deviation0.71.44.52.1-1.9-0.3-1.1-1.2-1.2-0.91.41.2-0.1-0.1-0.71.1-1.1-1.1
Left kidney weight1.67.423.9-4.94.43.11.5-2.13.4-0.8-0.32.32.82.92.4-2.21.72.0
Right kidney weight2.611.727.9-5.35.34.02.2-1.94.5-0.7-1.13.33.53.53.4-3.32.63.0
Cocaine induced anxiety2.94.220.6-4.53.90.30.60.92.70.9-0.70.71.81.91.6-1.51.71.4
Post-drug Anxiety3.33.526.1-5.13.80.20.5-0.02.20.00.0-0.11.51.50.7-0.60.70.5
Baseline Anxiety0.50.61.0-0.0-0.4-0.4-0.0-0.8-0.8-0.90.5-1.0-0.6-0.6-1.00.9-1.0-1.0
Tail length0.52.010.2-1.91.52.01.3-3.20.7-2.41.0-0.10.40.4-0.0-0.1-0.6-0.1
Length with tail0.31.34.9-0.81.21.91.8-2.20.9-1.6-0.10.50.20.20.6-0.90.10.7
Length without tail0.20.62.21.2-0.41.51.0-1.20.2-0.7-0.41.00.0-0.10.6-0.80.30.7
Times rat made contact with spout0.20.20.90.20.20.30.50.50.50.3-0.90.10.10.20.5-0.70.50.7
Lifetime Intake0.20.21.01.0-0.60.3-0.00.10.00.30.60.90.30.30.5-0.50.40.5
Liver weight, left1.11.87.7-0.10.72.82.4-2.60.6-2.1-0.4-0.0-0.4-0.40.2-0.8-0.20.6
Liver weight, right0.91.67.20.50.52.72.0-1.40.9-1.0-1.10.40.20.21.2-1.60.71.5
Locomotor activity0.60.94.6-2.11.5-0.9-0.60.60.81.1-0.90.10.70.70.4-0.30.80.3
Locomotor testing distance0.40.73.6-1.91.3-1.0-0.60.60.61.1-0.5-0.10.50.50.3-0.20.70.2
Locomotor testing rearing0.50.93.3-1.60.6-1.8-1.20.9-0.40.80.7-0.7-0.3-0.4-0.91.2-0.4-1.1
Locomotion in novel chamber0.30.43.70.5-0.20.90.7-0.4-0.1-0.3-1.9-0.4-0.2-0.20.2-0.40.10.3
Locomotion in novel chamber post-restriction0.30.52.20.8-0.51.30.7-1.2-0.1-1.50.50.1-0.2-0.2-0.20.1-0.6-0.2
Fecal boli incidents, locomotor time 10.30.41.51.2-1.0-0.2-0.90.9-0.21.0-0.20.60.40.40.5-0.20.50.3
Change in fecal boli incidents, locomotor task0.60.63.1-1.20.80.90.8-1.80.3-1.30.5-0.20.10.1-0.10.0-0.4-0.1
Time >=10cm from walls, locomotor time 10.70.71.31.0-1.10.1-0.3-0.5-1.2-0.70.8-1.0-0.8-0.8-1.00.9-1.0-0.9
Bouts of movement, locomotor time 11.31.55.81.2-1.2-2.2-2.12.4-0.72.00.10.40.10.1-0.10.60.3-0.4
Total resting periods, locomotor time 11.21.45.60.8-1.0-2.2-1.92.4-0.81.80.1-0.1-0.1-0.1-0.40.80.1-0.6
Rest time, locomotor task time 10.10.10.40.2-0.20.1-0.00.6-0.2-0.0-0.1-0.3-0.4-0.4-0.40.3-0.3-0.3
Distance moved, locomotor task time 10.20.32.01.4-0.8-0.00.60.1-0.4-0.1-0.6-0.6-0.7-0.7-0.0-0.2-0.00.2
Vertical activity count, locomotor time 10.30.61.81.3-1.00.30.5-0.7-0.8-1.00.1-0.8-1.0-1.0-0.70.4-0.8-0.4
Time >=10cm from walls, locomotor time 21.82.712.2-1.31.93.52.9-1.51.6-1.9-1.2-0.20.10.10.8-1.50.31.3
Bouts of movement, locomotor time 21.11.78.22.9-2.10.90.8-0.5-1.4-1.0-0.4-1.3-1.6-1.6-0.80.4-0.9-0.4
Total resting periods, locomotor time 21.11.99.83.1-2.30.80.7-0.3-1.4-1.0-0.4-1.2-1.7-1.7-0.90.5-1.0-0.5
Rest time, locomotor task time 21.01.35.3-0.0-0.5-2.3-2.11.9-0.61.50.70.50.10.1-0.71.1-0.2-1.0
Distance moved, locomotor task time 21.01.13.9-0.91.41.82.0-1.01.1-0.8-0.9-0.30.10.10.7-1.20.51.1
Vertical activity count, locomotor time 21.41.96.30.8-0.12.52.4-2.2-0.2-2.2-0.5-1.3-1.2-1.2-0.4-0.4-0.70.2
Light reinforcement 10.92.310.3-0.51.81.13.21.21.6-0.2-2.5-1.0-1.0-1.10.6-1.70.81.6
Light reinforcement 20.20.31.30.1-0.2-1.2-0.31.0-0.40.70.4-0.3-0.6-0.5-0.60.5-0.2-0.4
Bone: marrow area0.40.95.00.9-1.10.1-0.3-1.1-1.0-1.02.2-0.6-0.4-0.5-0.80.9-1.0-0.9
Bone: maximum diameter0.40.81.91.3-0.71.41.2-1.2-0.3-1.31.1-0.6-0.6-0.7-0.2-0.2-0.50.1
Bone: maximum force0.50.93.6-0.10.51.91.7-1.80.4-1.50.0-0.1-0.3-0.30.1-0.5-0.20.4
Bone: maximum moment0.40.73.20.00.41.81.5-1.60.3-1.4-0.1-0.1-0.3-0.30.1-0.5-0.20.4
Mean time between licks in bursts0.30.82.5-1.10.4-1.2-1.60.40.31.30.41.41.31.10.50.10.6-0.0
Mean num. licks in bursts0.71.13.1-1.51.80.81.20.61.40.2-0.9-0.00.60.40.9-1.20.91.1
Cd content in liver0.40.42.01.4-0.91.00.7-0.4-0.3-0.7-1.0-0.4-0.4-0.50.0-0.2-0.20.2
Co content in liver0.50.61.20.8-0.50.3-0.50.40.30.7-0.31.00.91.01.1-0.80.90.9
Cu content in liver0.81.02.20.7-1.1-0.9-1.1-0.5-1.2-0.51.5-0.3-0.5-0.4-1.11.3-1.1-1.3
Fe content in liver3.34.07.52.4-2.3-1.40.20.1-2.3-1.10.7-2.6-2.7-2.7-2.52.0-2.2-2.0
K content in liver0.30.32.50.2-0.40.3-0.2-0.8-0.4-0.71.6-0.1-0.10.0-0.40.4-0.5-0.5
Mg content in liver1.81.96.42.5-2.31.10.0-1.7-1.6-1.70.8-0.8-0.8-0.7-0.90.9-1.4-0.9
Mn content in liver0.91.04.3-0.60.91.81.3-0.80.9-0.8-2.1-0.00.30.20.7-1.00.40.9
Na content in liver0.60.71.6-1.00.2-1.3-1.1-0.1-0.50.01.2-0.2-0.2-0.2-1.01.2-0.8-1.2
Rb content in liver0.91.05.10.40.12.31.0-1.60.6-1.1-0.10.60.80.81.0-1.00.40.9
Se content in liver0.50.61.71.3-1.00.60.5-0.6-0.7-1.00.7-0.8-0.8-0.8-0.60.4-0.8-0.4
Sr content in liver0.70.62.1-1.41.1-0.3-0.50.30.70.90.10.90.90.90.6-0.40.80.4
Zn content in liver2.73.07.31.5-1.9-1.1-0.8-0.8-2.0-1.22.7-1.3-1.5-1.3-2.12.1-2.0-2.1
Bone: minimum diameter1.01.83.6-0.81.31.70.9-0.41.60.3-0.71.31.51.21.9-1.81.51.8
Time in familiar zone, hab. session 10.80.82.30.8-1.1-1.5-1.40.9-0.90.71.3-0.0-0.30.0-0.60.9-0.3-0.8
Time in novel zone, hab. session 11.01.04.2-0.00.52.01.9-1.20.6-1.3-1.4-0.6-0.2-0.40.3-0.8-0.00.7
Total zone transitions, hab. session 10.91.33.6-1.91.4-1.5-1.11.20.81.60.21.21.11.00.6-0.21.00.3
Total locomotion distance, hab. session 11.01.55.4-2.31.7-1.4-0.91.41.11.6-0.21.01.21.00.7-0.31.00.4
Locomotion velocity, hab. session 11.62.27.4-2.72.1-1.7-1.11.71.32.1-0.41.31.41.20.8-0.51.30.6
Time in familiar zone, hab. session 21.01.05.82.4-1.80.40.30.1-1.1-0.6-0.1-1.1-1.0-1.0-0.50.3-0.7-0.3
Time in novel zone, hab. session 21.11.14.0-2.01.80.80.4-0.51.40.2-0.31.11.11.11.0-0.90.90.9
Total zone transitions, hab. session 21.11.44.6-2.11.5-1.1-1.20.10.71.11.91.61.21.20.5-0.00.70.1
Total locomotion distance, hab. session 20.50.64.1-2.01.5-0.5-0.10.20.80.50.70.60.60.50.2-0.10.40.1
Locomotion velocity, hab. session 20.60.84.6-2.21.7-0.8-0.20.40.80.70.70.70.60.60.2-0.10.50.2
Novel to familiar place preference ratio0.91.02.9-1.01.31.51.7-0.41.0-0.7-1.7-0.6-0.10.00.5-0.90.30.8
Novelty place preference0.90.92.9-1.01.31.41.6-0.31.0-0.6-1.7-0.50.10.10.6-1.00.40.9
Time in novel zone, NPP test0.80.82.8-0.81.01.51.6-0.30.9-0.7-1.7-0.7-0.1-0.10.4-0.90.30.8
Total zone transitions, NPP test1.42.07.4-1.60.5-2.1-2.50.6-0.01.52.71.51.41.20.10.70.4-0.6
Total locomotion distance, NPP test1.82.59.8-3.11.9-1.3-1.80.61.21.61.41.72.01.90.9-0.11.00.2
Locomotion velocity, NPP test2.12.911.0-3.32.1-1.4-1.90.71.31.81.41.92.22.11.0-0.21.20.3
Intraocular pressure0.60.83.31.8-1.2-0.5-0.31.2-0.41.3-1.50.2-0.2-0.30.5-0.60.80.7
Delta distance traveled before/after self-admin0.40.51.71.3-0.9-0.50.20.6-0.6-0.11.1-0.5-0.9-0.9-0.50.3-0.4-0.3
Delta ambulatory time before/after self-admin0.30.41.60.8-0.4-0.80.21.3-0.20.10.4-0.5-0.9-0.9-0.50.3-0.3-0.3
Parametrial fat weight1.02.412.6-3.63.1-0.40.50.91.90.9-0.60.41.11.30.9-1.01.20.9
Pavlov. Cond. lever latency1.62.010.43.2-2.61.50.6-1.1-1.5-1.4-0.2-1.2-1.0-1.1-0.50.3-0.9-0.3
Pavlov. Cond. magazine entry latency1.11.46.5-2.62.5-0.11.50.71.50.1-1.6-0.3-0.2-0.20.1-0.60.40.5
Pavlov. Cond. change in total contacts1.01.18.0-2.81.9-1.0-0.4-0.50.6-0.11.00.30.10.3-0.60.7-0.4-0.8
Pavlov. Cond. index score1.11.47.6-2.82.4-1.10.21.21.41.0-0.70.60.30.50.3-0.40.70.3
Pavlov. Cond. latency score1.72.110.0-3.22.9-1.10.21.41.81.3-1.00.80.60.80.6-0.71.10.7
Pavlov. Cond. lever contacts1.82.212.1-3.52.8-1.6-0.51.21.51.4-0.21.00.91.00.4-0.20.90.2
Pavlov. Cond. magazine entry number0.81.05.12.3-2.3-0.1-1.3-0.3-1.40.00.9-0.10.10.0-0.20.6-0.4-0.5
Pavlov. Cond. intertrial magazine entries3.13.717.04.1-3.70.2-0.4-0.9-2.6-1.30.1-1.3-1.7-1.5-1.51.4-1.7-1.4
Pavlov. Cond. lever-magazine prob. diff.1.21.48.0-2.82.3-1.3-0.21.21.31.1-0.40.70.50.60.2-0.20.70.2
Pavlov. Cond. response bias0.70.86.0-2.51.9-1.20.10.50.70.30.40.0-0.1-0.1-0.50.4-0.1-0.4
Pavlov. Cond. lever latency1.31.88.7-0.8-0.3-2.3-3.00.9-0.61.61.71.01.21.1-0.11.00.1-0.9
Pavlov. Cond. magazine entry latency1.41.65.31.1-0.31.22.3-0.5-0.4-1.6-1.0-1.8-1.9-1.9-1.00.1-1.0-0.2
Pavlov. Cond. change in total contacts0.91.44.00.5-0.01.02.0-0.9-0.4-1.8-0.7-1.6-1.7-1.7-1.20.4-1.2-0.5
Pavlov. Cond. index score1.72.37.21.4-0.51.72.7-1.1-0.5-2.2-0.8-2.0-2.2-2.1-1.10.1-1.3-0.3
Pavlov. Cond. latency score1.41.95.41.2-0.41.52.3-1.1-0.5-2.0-0.6-1.7-1.9-1.9-1.10.2-1.2-0.3
Pavlov. Cond. lever contacts1.62.210.61.20.22.43.2-0.80.5-1.8-1.9-1.3-1.4-1.40.0-1.1-0.20.9
Pavlov. Cond. magazine entry number1.41.74.4-1.10.5-1.2-2.10.80.61.90.11.81.91.91.2-0.41.30.5
Pavlov. Cond. intertrial magazine entries0.71.12.4-0.40.40.2-0.60.20.91.0-0.91.51.51.51.4-1.01.31.0
Pavlov. Cond. lever-magazine prob. diff.1.62.16.71.2-0.41.52.6-0.9-0.4-2.1-0.9-1.9-2.1-2.0-1.10.1-1.2-0.3
Pavlov. Cond. response bias2.23.012.41.7-0.32.53.5-1.1-0.0-2.3-1.6-2.0-2.2-2.1-0.6-0.6-0.90.4
Time in closed arm before self-admin0.81.03.11.0-1.0-1.8-0.51.2-1.00.7-1.4-1.1-1.2-1.1-0.80.7-0.4-0.6
Time in closed arm after self-admin1.21.34.5-0.1-0.4-1.3-0.20.6-1.0-0.2-0.1-2.1-1.4-1.5-1.51.3-1.1-1.3
Time in open arm before self-admin0.40.51.50.6-0.01.20.8-0.10.50.1-0.40.40.30.10.9-1.00.81.0
Time in open arm after self-admin1.31.45.32.0-1.71.60.3-2.3-0.8-1.61.40.60.20.3-0.00.1-0.7-0.2
Bone: periosteal estimation0.20.51.91.0-0.61.10.6-1.3-0.3-1.01.4-0.1-0.2-0.20.1-0.2-0.30.1
Bone: periosteal perimeter0.40.61.80.00.41.30.8-0.80.7-0.31.30.60.60.50.9-1.00.60.9
Bone: post-yield work0.60.94.7-2.21.1-0.9-1.3-0.60.20.31.20.81.00.9-0.10.7-0.1-0.6
Progressive ratio test 1 active lever presses0.10.10.20.5-0.20.10.30.2-0.10.10.4-0.4-0.4-0.4-0.1-0.10.00.1
Progressive ratio test 1 breakpoint0.00.00.20.00.1-0.00.20.20.00.20.5-0.3-0.2-0.2-0.0-0.10.10.1
Progressive ratio test 1 inactive lever presses0.30.42.3-1.30.7-0.10.1-0.1-0.0-0.21.5-0.9-0.1-0.1-0.50.4-0.3-0.4
Progressive ratio test 2 active lever presses0.40.51.71.3-0.90.40.6-0.2-0.6-0.71.0-0.6-0.9-0.8-0.50.2-0.6-0.3
Progressive ratio test 2 breakpoint0.50.62.41.6-1.00.60.7-0.3-0.6-0.80.9-0.5-0.9-0.9-0.50.2-0.6-0.2
Progressive ratio test 2 inactive lever presses0.10.21.9-0.30.20.30.3-0.40.0-0.51.4-0.1-0.00.0-0.10.1-0.2-0.1
Incentive Sensitization - Responses0.20.32.01.4-1.00.60.2-0.3-0.4-0.30.60.2-0.2-0.2-0.0-0.1-0.20.1
Incentive Sensitization - Breakpoint0.30.32.51.6-1.10.70.3-0.2-0.4-0.40.50.2-0.3-0.3-0.1-0.0-0.20.0
Sum of active levers in priming session hrs 5-60.60.61.50.8-1.1-0.4-1.2-0.1-0.9-0.20.90.4-0.10.0-0.71.1-0.8-1.1
Progressive ratio0.10.20.9-0.3-0.0-0.00.2-0.4-0.5-0.2-0.2-1.0-0.5-0.5-0.60.4-0.4-0.4
Food seeking constrained by brief footshock0.20.21.2-1.10.80.40.1-0.10.40.10.4-0.10.50.50.2-0.20.30.2
Seeking ratio, punishment vs. effort0.10.10.20.2-0.00.20.10.30.30.10.40.40.20.20.3-0.30.30.3
Retroperitoneal fat weight1.25.220.2-1.93.03.64.5-2.02.4-2.0-2.1-0.6-0.10.11.3-2.50.92.2
Reaction time number correct0.81.68.51.3-1.21.60.4-2.9-1.0-2.20.50.0-0.6-0.5-0.70.7-1.3-0.8
Reaction time mean minus median0.10.31.10.10.30.91.0-0.40.4-0.6-0.7-0.1-0.2-0.40.3-0.50.10.5
Reaction time mean minus median AUC0.30.93.4-0.20.81.81.7-1.00.9-1.1-1.00.00.0-0.10.6-1.00.30.9
Reaction time num false alarms0.20.31.8-1.31.0-0.20.00.30.60.1-0.20.20.30.50.2-0.10.20.1
Reaction time num false alarms AUC0.10.10.4-0.70.4-0.50.00.30.1-0.2-0.2-0.4-0.3-0.2-0.40.3-0.3-0.4
Reaction time trials correct on left0.81.68.51.3-1.21.60.4-2.9-1.0-2.20.50.0-0.6-0.5-0.70.7-1.3-0.8
Reaction time trials on left0.91.68.41.3-1.21.70.5-2.9-1.0-2.20.4-0.1-0.6-0.5-0.70.7-1.3-0.8
Reaction time mean1.21.94.22.1-1.8-0.50.30.1-1.6-0.80.6-1.9-2.0-2.0-1.51.1-1.3-1.1
Reaction time mean AUC0.91.43.31.8-1.5-0.10.5-0.1-1.3-0.80.7-1.6-1.7-1.7-1.20.8-1.1-0.8
Median of all reaction times1.92.74.92.2-2.2-1.1-0.20.4-2.0-0.50.9-2.1-2.2-2.1-1.81.5-1.5-1.5
Reaction time omissions0.60.85.0-0.20.90.91.50.61.0-0.4-2.2-0.1-0.1-0.40.5-0.90.40.9
Reaction time false alarm rate0.40.52.6-1.10.9-1.0-0.01.60.60.9-0.6-0.30.10.20.1-0.20.50.2
Reaction time premature initiation rate0.91.24.6-2.21.7-1.50.51.60.50.6-1.0-1.7-0.7-0.7-0.60.2-0.0-0.2
Reaction time premature initiations0.50.83.4-1.20.8-0.50.7-0.1-0.2-0.7-0.5-1.8-1.1-1.1-1.10.7-0.8-0.7
Std. dev. reaction times0.50.92.81.5-0.61.31.7-0.4-0.0-1.0-1.0-0.8-1.0-1.10.1-0.6-0.10.5
Reaction time trials completed0.91.68.41.3-1.21.70.5-2.9-1.0-2.20.4-0.1-0.6-0.5-0.70.7-1.3-0.8
Reaction time trials AUC1.22.39.11.7-1.61.60.5-3.0-1.3-2.50.4-0.4-1.0-1.0-1.11.0-1.7-1.1
Run reversals in cocaine runway, females1.01.04.9-1.50.5-0.1-1.3-1.3-0.3-0.22.20.50.80.7-0.41.0-0.5-1.0
Run reversals in cocaine runway, males0.10.10.30.2-0.5-0.5-0.60.2-0.40.1-0.0-0.1-0.2-0.2-0.40.5-0.3-0.5
Latency to leave start box in cocaine runway0.50.62.40.4-0.40.20.5-0.3-0.6-0.8-0.0-1.6-1.0-1.1-0.90.6-0.8-0.6
Latency to leave start box in cocaine runway, F0.10.10.3-0.40.2-0.0-0.40.30.10.5-0.2-0.20.30.10.1-0.00.30.1
Latency to leave start box in cocaine runway, M2.72.67.30.8-0.70.31.6-1.2-1.1-2.30.1-2.7-2.2-2.2-1.91.2-1.9-1.3
Std. dev. time between licks in bursts1.11.52.6-0.61.11.40.8-0.41.40.3-1.21.51.31.21.6-1.61.41.6
Total sessions with >9 infusions0.91.12.50.10.50.40.31.10.91.5-1.00.90.70.71.4-1.51.61.6
Short access day 1 total inactive lever presses1.31.73.6-1.41.51.2-0.1-0.01.60.6-0.11.91.71.71.6-1.31.41.3
Short access day 10 total inactive lever presses1.02.418.4-4.32.40.1-0.3-1.30.6-1.01.7-1.00.80.8-0.71.0-0.7-1.1
Short access day 1 total infusions0.70.92.2-0.70.60.2-0.50.60.71.5-0.20.91.21.21.2-1.01.41.1
Short access day 10 total infusions0.30.41.40.10.40.00.31.20.60.9-0.10.50.30.40.7-0.80.80.8
Short access total infusions0.40.51.31.1-0.50.20.00.70.21.0-0.30.90.40.40.9-0.91.01.0
Short access day 1 locomotion0.40.41.70.00.2-0.3-0.11.30.41.3-0.70.20.20.20.7-0.71.00.8
Short access day 10 total locomotion1.73.29.7-0.51.01.1-0.30.31.81.3-0.53.12.52.52.5-2.02.12.0
Short access total locomotion2.53.05.5-0.81.61.00.71.42.11.5-1.22.01.61.62.3-2.32.32.3
One hour access (0.3 mA shock)4.24.815.84.0-3.70.2-0.8-1.7-2.7-1.92.7-0.1-1.6-1.5-1.92.0-2.3-2.0
Compulsive drug intake3.13.717.24.1-3.60.1-0.9-0.9-2.3-1.51.10.4-1.3-1.3-1.51.7-1.9-1.7
One hour access (shock baseline)0.10.10.40.10.20.10.60.40.2-0.20.5-0.1-0.4-0.4-0.1-0.2-0.10.1
Social response proportion2.52.910.6-0.50.1-0.31.4-0.4-0.9-2.00.5-3.3-2.3-2.1-2.31.5-2.1-1.7
Social responses2.43.17.91.7-1.3-1.10.90.5-1.6-1.20.3-2.5-2.8-2.7-2.31.6-2.0-1.6
Social time1.41.94.52.1-1.70.20.9-0.7-1.4-1.40.2-1.9-1.9-1.8-1.30.8-1.3-0.8
Soleus weight0.61.86.52.5-2.2-0.10.20.0-1.6-0.9-0.1-1.4-1.5-1.5-1.20.9-1.2-1.0
Bone: stiffness0.40.62.1-0.91.01.21.2-1.50.5-1.20.4-0.0-0.2-0.2-0.1-0.2-0.30.1
Tibialis anterior weight1.13.710.33.2-2.70.81.1-0.8-2.1-2.1-0.2-2.4-2.3-2.4-1.81.2-2.0-1.3
Time to tail flick, vehicle, before self-admin0.50.51.2-0.10.51.00.5-0.50.60.5-0.30.60.30.21.0-1.11.01.1
Time to tail flick, vehicle, after self-admin0.81.16.42.5-1.90.90.3-1.6-1.1-0.70.40.1-0.6-0.6-0.1-0.0-0.40.1
Time to tail flick, test, before self-admin0.10.10.30.20.3-0.10.50.40.20.2-0.5-0.2-0.4-0.50.1-0.40.20.4
Time to tail flick, test, after self-admin0.40.42.21.0-0.10.61.00.00.4-0.4-1.50.4-0.1-0.10.5-0.80.30.8
Delta time to tail flick, vehicle, before/after SA1.31.33.81.9-1.60.80.4-1.6-1.1-1.90.4-0.2-0.7-0.6-0.80.7-1.3-0.8
Delta time to tail flick, test, before/after SA0.20.21.60.7-0.30.20.50.00.2-0.1-1.30.30.10.10.4-0.50.30.5
Tibia length1.85.015.8-3.84.00.91.30.23.11.0-1.12.01.81.82.1-2.32.22.2
Ambulatory time before self-admin0.60.81.9-0.50.61.40.6-0.80.80.10.10.91.11.31.1-1.10.91.1
Ambulatory time after self-admin0.40.41.40.9-0.9-0.20.2-0.3-0.8-0.41.2-0.6-0.6-0.5-0.60.5-0.6-0.5
Bone: tissue strength1.11.15.5-2.31.80.2-0.1-0.21.20.4-0.10.91.21.10.8-0.60.80.6
Total heroin consumption0.81.03.2-1.80.9-0.2-1.30.40.51.4-0.40.61.41.50.8-0.31.00.4
Bone: trabecular number0.61.14.80.1-0.31.10.5-2.2-0.5-1.72.0-0.4-0.2-0.3-0.60.5-1.0-0.6
Bone: trabecular spacing1.11.57.50.90.10.00.92.30.81.3-2.7-0.1-0.1-0.30.9-1.31.21.3
Bone: trabecular thickness1.62.05.51.8-1.9-0.7-0.7-0.8-1.8-0.92.4-0.9-1.2-1.0-1.51.5-1.5-1.5
Bone: trabecular tissue density2.02.910.2-1.1-0.5-2.9-3.2-0.6-1.40.52.40.60.30.5-1.52.4-1.2-2.3
Water consumed over 24 hours0.71.02.51.5-1.3-0.50.10.0-1.2-0.5-0.2-1.0-1.6-1.1-1.20.9-1.0-0.9
Number of responses in last shaping day0.80.82.7-1.01.2-0.1-0.01.61.01.3-0.80.60.50.50.8-0.81.10.8