Pkd2l2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative polyA	NM_001106156.1	0.03	0.02	1.0e-03	0.02	0.01	0.01	0.02	4.8e-04	2.5e-03	3.7e-03	1.7e-03
2	NAcc	alternative polyA	XM_063277220.1	0.03	0.02	1.1e-03	0.02	0.01	0.01	0.01	4.9e-04	3.2e-03	3.7e-03	1.7e-03
3	Adipose	gene expression	Pkd2l2	0.03	0.02	9.5e-04	0.02	0.02	0.02	0.02	1.5e-03	3.6e-03	9.6e-04	1.5e-03
4	Adipose	mRNA stability	Pkd2l2	0.02	0.01	5.2e-03	-0	0.01	0	0	5.1e-01	2.8e-02	3.7e-01	1.6e-01
5	NAcc	gene expression	Pkd2l2	0.02	0.01	5.9e-04	0.01	0.02	0.01	0.01	2.4e-03	1.4e-03	5.4e-03	6.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.2	0.3	0.7	-0.2	0.2	0.8	0.7	-0.4
Area under the delay curve	4.2	4.9	5.6	-2.2	2.2	1.9	2.4	-2.4
BMI with tail	7.4	25.6	32.8	5.7	-5.7	-5.0	-4.7	3.9
BMI without tail	7.6	23.1	28.7	5.4	-5.4	-4.5	-4.6	4.1
Body weight	7.7	33.8	42.2	6.5	-6.5	-5.7	-5.4	4.8
Weight adjusted by age	2.8	4.3	8.0	1.9	-1.9	-2.8	-1.9	1.6
Bone surface	0.4	0.6	1.4	-0.5	0.5	1.2	1.0	-0.7
Bone volume	0.2	0.3	1.1	-0.1	0.1	1.0	0.6	-0.3
Breakpoint value in progressive ratio session	0.2	0.2	0.4	-0.5	0.5	0.6	0.3	-0.2
Number of licking bursts	0.5	0.8	1.0	-0.9	0.9	0.6	1.0	-0.9
Context. condit. distance diff. score	0.0	0.0	0.1	-0.0	0.0	0.1	0.2	-0.4
Locomotion velocity, session 1	0.7	0.8	1.8	0.8	-0.8	-0.1	-0.9	1.3
Locomotion distance, session 1	0.0	0.0	0.1	0.0	-0.0	0.3	-0.3	0.3
Locomotion velocity, session 2	0.9	1.0	1.4	1.1	-1.1	0.3	-1.2	1.1
Locomotion distance, session 2	0.6	0.8	1.5	-0.9	0.9	1.2	0.7	-0.6
Locomotion velocity, session 3	0.3	0.3	0.4	0.6	-0.6	-0.5	-0.6	0.6
Locomotion distance, session 3	0.1	0.1	0.3	-0.3	0.3	-0.2	0.5	-0.5
Stereotopy head waving bouts, day 3	2.2	2.6	3.0	-1.6	1.6	1.7	1.6	-1.5
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.6	0.6	0.6	0.3	-0.3
Locomotion velocity, session 7	0.4	0.4	0.8	0.7	-0.7	-0.9	-0.2	0.2
Locomotion distance, session 7	0.4	0.5	0.8	-0.4	0.4	-0.6	0.9	-0.9
Stereotopy head waving bouts, day 7	0.3	0.3	0.5	0.5	-0.5	0.4	-0.7	0.6
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.2	-0.2	0.8	-0.5	0.3
Locomotion velocity, session 8	0.3	0.3	0.7	0.3	-0.3	0.5	-0.8	0.6
Locomotion distance, session 8	0.0	0.0	0.0	-0.1	0.1	0.1	0.0	-0.1
Degree of sensitization distance	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.3	0.1
Degree of sensitization stereotypy	0.3	0.3	0.8	0.2	-0.2	0.9	-0.6	0.4
Conditioned locomotion	0.1	0.1	0.2	0.5	-0.5	-0.1	0.2	-0.2
Cocaine response after cond. corrected	0.8	1.0	1.3	1.0	-1.0	-1.1	-0.8	1.0
Cocaine response after cond. not corrected	0.0	0.1	0.2	-0.1	0.1	-0.4	-0.1	0.2
Cocaine response before conditioning	5.3	6.3	7.8	-2.8	2.8	2.2	2.2	-2.5
Saline control response	0.9	1.2	1.5	-1.2	1.2	1.0	1.0	-1.1
Bone: connectivity density	1.5	2.4	5.0	-1.2	1.2	2.2	1.6	-1.3
Bone: cortical apparent density	0.4	0.6	0.9	-0.9	0.9	0.6	0.6	-0.7
Bone: cortical area	1.2	1.9	3.0	-1.3	1.3	0.6	1.7	-1.6
Bone: cortical porosity	1.3	1.4	2.2	1.0	-1.0	-1.5	-1.1	1.2
Bone: cortical porosity	0.9	0.9	1.7	0.8	-0.8	-1.3	-0.8	0.9
Bone: cortical thickness	1.1	1.8	3.3	-1.2	1.2	0.5	1.7	-1.8
Bone: cortical thickness	0.1	0.2	0.3	-0.1	0.1	0.4	0.5	-0.6
Bone: cortical tissue density	0.3	0.4	0.7	-0.8	0.8	0.5	0.5	-0.6
Condit. Reinf. active minus inactive responses	2.0	2.2	2.5	-1.5	1.5	1.4	1.6	-1.4
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.9	-1.2	1.2	0.7	1.3	-1.4
Condit. Reinf. active responses	1.7	2.1	3.8	-1.4	1.4	2.0	1.4	-0.9
Condit. Reinf. inactive responses	1.1	1.3	3.8	-0.9	0.9	1.9	1.0	-0.4
Incentive salience index mean	1.6	2.0	2.5	-1.6	1.6	1.4	1.4	-1.1
Condit. Reinf. lever presses	1.0	1.4	2.0	-1.4	1.4	1.2	1.1	-0.8
Condit. Reinf. active minus inactive responses	3.3	4.3	6.7	-2.6	2.6	1.3	2.0	-1.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.3	0.3	-0.7	-0.1	0.5
Condit. Reinf. active responses	8.8	12.2	17.1	-4.1	4.1	2.6	3.3	-3.0
Condit. Reinf. inactive responses	9.0	11.7	14.1	-3.7	3.7	3.0	3.3	-3.3
Condit. Reinf. lever presses	1.8	2.5	3.5	-1.9	1.9	0.8	1.7	-1.4
Condit. Reinf. lever reinforcers received	7.9	11.0	15.6	-4.0	4.0	2.5	3.1	-2.8
Conditioned reinforcement - actives	0.1	0.2	0.4	0.3	-0.3	0.3	-0.6	0.6
Conditioned reinforcement - inactives	0.4	0.5	1.0	-0.5	0.5	1.0	0.7	-0.8
Conditioned locomotion	0.1	0.1	0.2	0.2	-0.2	0.2	-0.4	0.5
Patch foraging indifference point 0 sec	2.0	3.7	4.5	-2.1	2.1	1.6	1.8	-1.9
Patch foraging indifference point AUC	3.2	4.6	8.0	-1.9	1.9	2.8	2.1	-1.8
Delay disc. indifference point, 0s delay	1.6	1.7	2.4	-1.3	1.3	0.8	1.5	-1.6
Delay disc. indifference point, 16s delay	4.8	5.3	5.8	-2.2	2.2	2.3	2.3	-2.4
Delay disc. indifference point, 2s delay	0.8	0.9	1.3	-0.9	0.9	0.4	1.1	-1.1
Delay disc. indifference point, 24s delay	0.9	1.0	1.3	-0.9	0.9	0.9	1.1	-1.1
Delay disc. indifference point, 4s delay	0.8	0.8	1.1	-0.9	0.9	0.6	1.0	-0.9
Delay disc. indifference point, 8s delay	5.1	6.0	7.0	-2.5	2.5	2.0	2.6	-2.6
Indifference point function ln k	7.4	12.9	18.4	3.4	-3.4	-4.3	-3.6	3.2
Indifference point function log k	7.4	12.9	18.4	3.4	-3.4	-4.3	-3.6	3.2
Patch foraging total patch changes 0 sec	1.8	3.3	3.9	-2.0	2.0	1.7	1.7	-1.7
Patch foraging total patch changes 12 sec	10.2	13.2	16.4	-3.6	3.6	4.1	3.5	-3.4
Patch foraging total patch changes 18 sec	4.2	6.4	9.7	-2.2	2.2	3.1	2.7	-2.3
Patch foraging total patch changes 24 sec	2.3	3.9	4.2	-1.9	1.9	2.0	2.0	-2.0
Patch foraging total patch changes 6 sec	4.1	6.3	6.6	-2.5	2.5	2.5	2.6	-2.5
Patch foraging time to switch 0 sec	0.1	0.2	0.3	0.5	-0.5	-0.3	-0.5	0.5
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.2
Patch foraging water rate 12 sec	0.4	0.9	1.6	1.2	-1.2	-0.7	-0.7	0.7
Patch foraging water rate 18 sec	0.1	0.2	0.3	0.4	-0.4	-0.1	-0.6	0.6
Patch foraging water rate 24 sec	0.2	0.3	0.5	0.7	-0.7	-0.0	-0.5	0.7
Patch foraging water rate 6 sec	0.1	0.1	0.3	0.5	-0.5	0.1	-0.1	0.2
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.6	-1.2	1.2	0.6	0.7	-0.5
Distance traveled before self-admin	0.3	0.4	0.6	-0.6	0.6	-0.4	0.8	-0.5
Distance traveled after self-admin	1.3	1.6	2.4	-1.5	1.5	0.6	1.4	-1.0
Extensor digitorum longus weight	2.2	8.8	11.2	3.1	-3.1	-3.4	-2.9	2.3
Bone: elastic displacement	0.8	1.0	1.3	0.9	-0.9	-0.9	-1.1	1.0
Bone: elastic work	1.8	2.4	3.1	1.4	-1.4	-1.6	-1.8	1.5
Bone: endosteal estimation	0.3	0.7	1.1	-0.9	0.9	1.1	0.8	-0.6
Bone: endosteal perimeter	0.0	0.1	0.1	-0.3	0.3	0.3	0.2	-0.2
Epididymis fat weight	2.2	7.7	8.9	2.9	-2.9	-2.4	-3.0	2.7
Delta time in closed arm before/after self-admin	1.9	1.8	2.6	1.0	-1.0	-1.4	-1.6	1.5
Delta time in open arm before/after self-admin	0.2	0.2	0.5	0.2	-0.2	0.4	0.6	-0.7
Diff in mean of infusions in LGA sessions	0.4	0.5	0.8	0.5	-0.5	-0.8	-0.7	0.9
Delay discount exponential model param	4.1	4.6	5.4	2.1	-2.1	-1.8	-2.3	2.3
Extinction: sum of active levers before priming	0.1	0.2	0.3	0.4	-0.4	-0.4	-0.3	0.5
Active lever presses in extinction session 6	1.9	1.9	3.2	-1.2	1.2	1.8	1.4	-1.2
Bone: final force	0.2	0.4	0.6	-0.6	0.6	-0.0	0.8	-0.8
Bone: final moment	0.1	0.1	0.2	-0.2	0.2	-0.3	0.4	-0.3
Food consumed during 24 hour testing period	1.1	1.5	2.3	1.5	-1.5	-1.1	-0.8	1.0
Glucose	7.6	12.0	13.2	3.6	-3.6	-3.0	-3.5	3.6
Heart weight	2.4	3.7	5.3	2.3	-2.3	-1.5	-1.8	1.5
Delay discount hyperbolic model param	4.0	4.5	5.4	2.1	-2.1	-1.7	-2.3	2.3
Intermittent access intake day 1-15 change	0.1	0.3	0.6	0.6	-0.6	0.0	-0.8	0.4
Intermittent access intake escalation	0.2	0.4	0.8	0.6	-0.6	-0.1	-0.9	0.6
Intermittent access intake escalation 2	0.5	0.6	0.8	0.8	-0.8	-0.7	-0.9	0.6
Intermitt. access day 1 inactive lever presses	0.1	0.5	0.6	-0.8	0.8	0.8	0.7	-0.6
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.3	0.0	-0.0	0.6	-0.0	-0.0
Intermitt. access escalation Index	0.5	0.7	0.8	0.8	-0.8	-0.9	-0.7	0.8
Intermittent access day 1 total infusions	0.2	0.4	1.3	-0.6	0.6	1.2	0.1	-0.0
Intermittent access day 15 total infusions	0.2	0.3	1.1	-0.1	0.1	1.0	-0.5	0.4
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.9	-0.1	0.1	1.0	-0.5	0.2
Intermittent access total infusions	0.4	0.5	1.0	0.4	-0.4	0.5	-1.0	1.0
Intermittent access day 1 locomotion	0.1	0.2	0.6	-0.3	0.3	0.8	-0.1	0.1
Intermittent access day 15 total locomotion	0.9	1.6	2.3	1.3	-1.3	-0.6	-1.5	1.4
Intermittent access total locomotion	0.5	0.6	1.1	0.6	-0.6	-0.1	-1.1	1.0
Intermittent access standard deviation	0.2	0.5	1.0	0.5	-0.5	0.5	-1.0	0.8
Left kidney weight	0.7	3.1	3.8	1.9	-1.9	-1.6	-1.6	1.7
Right kidney weight	0.1	0.3	0.7	0.8	-0.8	-0.1	-0.5	0.4
Cocaine induced anxiety	0.2	0.3	0.5	0.7	-0.7	-0.4	-0.4	0.7
Post-drug Anxiety	0.7	0.8	1.1	1.1	-1.1	-0.6	-0.7	0.8
Baseline Anxiety	0.4	0.5	0.8	0.9	-0.9	-0.4	-0.6	0.3
Tail length	0.3	1.2	1.9	1.1	-1.1	-0.6	-1.2	1.4
Length with tail	1.1	4.7	5.3	2.3	-2.3	-1.9	-2.1	2.2
Length without tail	0.6	2.0	2.6	1.6	-1.6	-1.2	-1.4	1.3
Times rat made contact with spout	0.1	0.2	0.4	0.6	-0.6	0.2	0.1	0.2
Lifetime Intake	0.7	0.8	1.7	0.6	-0.6	0.3	-1.3	1.3
Liver weight, left	0.4	0.7	1.3	-1.1	1.1	1.1	0.3	0.0
Liver weight, right	2.5	4.3	8.4	-2.0	2.0	2.9	1.6	-1.6
Locomotor activity	0.1	0.2	0.4	-0.2	0.2	-0.3	0.6	-0.7
Locomotor testing distance	0.1	0.1	0.3	-0.0	0.0	-0.5	0.4	-0.3
Locomotor testing rearing	0.5	1.1	1.2	-1.1	1.1	1.0	1.0	-1.1
Locomotion in novel chamber	0.2	0.3	0.6	0.3	-0.3	0.4	-0.8	0.8
Locomotion in novel chamber post-restriction	0.2	0.4	0.7	0.8	-0.8	-0.2	-0.6	0.2
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	0.2	-0.2	-0.4	-0.6	0.5
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	0.1	-0.1	-0.8	-0.4	0.4
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.7	0.7	-0.7	-1.3	-0.6	0.8
Bouts of movement, locomotor time 1	1.0	1.1	1.6	-0.9	0.9	1.3	1.0	-1.1
Total resting periods, locomotor time 1	0.7	0.8	1.0	-0.9	0.9	1.0	0.9	-0.9
Rest time, locomotor task time 1	0.1	0.1	0.2	0.5	-0.5	-0.3	-0.4	0.2
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.2	0.2	0.0	0.4	-0.4
Vertical activity count, locomotor time 1	0.2	0.4	1.6	0.5	-0.5	-1.3	-0.1	0.1
Time >=10cm from walls, locomotor time 2	3.4	5.0	5.9	2.2	-2.2	-2.4	-2.1	2.2
Bouts of movement, locomotor time 2	0.2	0.4	0.7	-0.6	0.6	0.9	0.5	-0.6
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.2	0.2	0.5	0.2	-0.3
Rest time, locomotor task time 2	1.4	1.8	2.5	1.4	-1.4	-1.6	-1.1	1.0
Distance moved, locomotor task time 2	0.2	0.3	0.5	-0.3	0.3	0.2	0.7	-0.7
Vertical activity count, locomotor time 2	0.3	0.4	0.9	-0.6	0.6	-0.1	0.9	-0.8
Light reinforcement 1	1.3	3.2	3.3	-1.8	1.8	1.7	1.8	-1.8
Light reinforcement 2	3.2	4.9	5.8	-2.3	2.3	1.9	2.4	-2.3
Bone: marrow area	0.3	0.7	1.1	-0.8	0.8	1.1	0.8	-0.6
Bone: maximum diameter	1.2	2.3	3.0	-1.6	1.6	1.1	1.7	-1.5
Bone: maximum force	0.1	0.1	0.6	-0.0	0.0	-0.7	0.2	-0.2
Bone: maximum moment	0.1	0.2	0.9	0.3	-0.3	-1.0	-0.2	0.2
Mean time between licks in bursts	0.4	0.9	1.4	1.2	-1.2	-1.1	-0.6	0.6
Mean num. licks in bursts	0.8	1.2	1.8	1.3	-1.3	-0.4	-1.0	1.1
Cd content in liver	0.7	0.8	1.4	-0.6	0.6	0.7	1.1	-1.2
Co content in liver	1.0	1.2	1.7	1.3	-1.3	-0.8	-0.7	1.0
Cu content in liver	4.1	4.8	5.6	-2.3	2.3	2.4	2.0	-1.9
Fe content in liver	0.5	0.6	1.2	-0.7	0.7	0.6	1.1	-0.7
K content in liver	1.0	1.0	1.7	-1.3	1.3	0.9	0.7	-0.6
Mg content in liver	1.3	1.4	1.9	-1.4	1.4	1.2	0.9	-0.8
Mn content in liver	0.1	0.1	0.2	0.3	-0.3	0.0	-0.4	0.3
Na content in liver	0.4	0.4	0.7	-0.8	0.8	-0.3	0.6	-0.2
Rb content in liver	1.2	1.4	5.0	-0.8	0.8	2.2	0.5	-0.6
Se content in liver	0.4	0.4	1.6	-0.4	0.4	1.3	0.4	-0.3
Sr content in liver	0.7	0.6	0.9	-0.9	0.9	0.4	0.9	-0.8
Zn content in liver	7.2	8.0	9.3	-3.1	3.1	2.8	2.7	-2.6
Bone: minimum diameter	0.5	0.8	1.3	-1.0	1.0	0.5	1.1	-0.9
Time in familiar zone, hab. session 1	0.4	0.4	0.7	0.8	-0.8	-0.8	-0.3	0.4
Time in novel zone, hab. session 1	1.4	1.4	1.7	-1.3	1.3	1.1	1.0	-1.2
Total zone transitions, hab. session 1	2.5	3.5	4.5	1.7	-1.7	-2.1	-1.7	2.1
Total locomotion distance, hab. session 1	0.1	0.1	0.6	0.1	-0.1	-0.3	-0.1	0.8
Locomotion velocity, hab. session 1	0.1	0.2	0.8	0.1	-0.1	-0.1	-0.2	0.9
Time in familiar zone, hab. session 2	4.1	4.4	5.8	-1.8	1.8	2.4	2.2	-2.2
Time in novel zone, hab. session 2	3.1	3.2	4.2	1.6	-1.6	-1.8	-1.9	2.0
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.3	-0.3	-0.2	-0.5	0.5
Total locomotion distance, hab. session 2	0.2	0.3	0.5	-0.5	0.5	0.7	0.5	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.2	0.2	0.4	0.2	0.1
Novel to familiar place preference ratio	1.8	1.9	5.7	1.1	-1.1	-2.4	-1.0	0.8
Novelty place preference	2.1	2.3	6.3	1.2	-1.2	-2.5	-1.1	0.9
Time in novel zone, NPP test	2.0	2.1	6.1	1.2	-1.2	-2.5	-1.0	0.8
Total zone transitions, NPP test	0.1	0.1	0.3	-0.0	0.0	-0.3	-0.3	0.6
Total locomotion distance, NPP test	0.4	0.5	1.3	-0.8	0.8	1.1	0.5	-0.0
Locomotion velocity, NPP test	0.5	0.8	1.5	-0.9	0.9	1.2	0.7	-0.2
Intraocular pressure	5.2	7.5	8.9	3.0	-3.0	-2.7	-2.7	2.3
Delta distance traveled before/after self-admin	1.7	1.8	3.2	-1.3	1.3	1.8	1.2	-0.9
Delta ambulatory time before/after self-admin	1.6	2.0	3.4	-1.3	1.3	1.9	1.4	-1.0
Parametrial fat weight	0.5	1.2	1.8	1.1	-1.1	-0.6	-1.3	1.1
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.0	-0.0	-0.5	0.2	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	-0.6	0.6	0.3	0.5	-0.6
Pavlov. Cond. change in total contacts	0.1	0.2	0.4	-0.3	0.3	0.6	0.4	-0.3
Pavlov. Cond. index score	0.0	0.0	0.1	-0.2	0.2	0.3	0.1	0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	0.0	-0.0	0.1	-0.2	0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.5	-0.3	0.3	0.7	0.0	0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.3	-0.3	-0.2	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	-0.4	0.4	0.5	0.5	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.3	0.3	0.5	0.2	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.1	-0.4	0.4	0.4	0.3	-0.2
Pavlov. Cond. lever latency	1.3	1.7	2.6	1.6	-1.6	-0.9	-1.3	1.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.3	0.3	0.2	0.1	0.1
Pavlov. Cond. change in total contacts	1.7	2.7	4.1	-2.0	2.0	1.1	1.6	-1.3
Pavlov. Cond. index score	0.7	0.9	1.5	-1.2	1.2	0.7	0.9	-0.6
Pavlov. Cond. latency score	0.6	0.8	1.3	-1.1	1.1	0.7	0.8	-0.5
Pavlov. Cond. lever contacts	1.1	1.5	2.2	-1.5	1.5	0.9	1.2	-0.9
Pavlov. Cond. magazine entry number	1.0	1.2	1.8	1.3	-1.3	-0.9	-0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.0	0.0	0.3	0.5	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.4	-1.2	1.2	0.6	0.9	-0.5
Pavlov. Cond. response bias	2.1	2.8	3.9	-2.0	2.0	1.2	1.7	-1.4
Time in closed arm before self-admin	1.5	1.9	2.6	1.6	-1.6	-1.5	-1.0	0.9
Time in closed arm after self-admin	0.7	0.7	1.3	0.7	-0.7	-1.1	-0.8	0.9
Time in open arm before self-admin	0.8	0.9	1.5	-1.2	1.2	1.2	0.4	-0.4
Time in open arm after self-admin	0.1	0.1	0.2	-0.1	0.1	0.5	0.4	-0.4
Bone: periosteal estimation	0.6	1.2	1.6	-1.1	1.1	0.8	1.3	-1.2
Bone: periosteal perimeter	0.3	0.5	0.6	-0.7	0.7	0.4	0.7	-0.7
Bone: post-yield work	0.1	0.2	0.3	-0.4	0.4	-0.6	0.3	-0.2
Progressive ratio test 1 active lever presses	0.3	0.3	0.6	0.4	-0.4	0.2	-0.8	0.8
Progressive ratio test 1 breakpoint	0.2	0.3	0.5	0.4	-0.4	0.3	-0.7	0.7
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.0	-0.0	0.5	-0.4	0.4
Progressive ratio test 2 active lever presses	0.8	0.9	1.9	0.8	-0.8	-0.0	-1.3	1.4
Progressive ratio test 2 breakpoint	0.8	0.9	1.8	0.7	-0.7	0.0	-1.2	1.3
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	0.3	-0.3	0.3	-0.6	0.6
Incentive Sensitization - Responses	0.2	0.3	0.5	0.6	-0.6	0.0	-0.6	0.7
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	0.6	-0.6	-0.0	-0.6	0.7
Sum of active levers in priming session hrs 5-6	6.3	5.8	7.8	-2.3	2.3	2.8	2.5	-2.1
Progressive ratio	0.2	0.3	0.5	-0.7	0.7	0.7	0.3	-0.4
Food seeking constrained by brief footshock	0.5	0.6	1.0	-0.7	0.7	1.0	0.7	-0.7
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.3	-0.3	-0.0	0.0	-0.2
Retroperitoneal fat weight	1.7	7.4	8.1	2.8	-2.8	-2.8	-2.8	2.4
Reaction time number correct	1.1	2.1	2.7	1.7	-1.7	-1.5	-1.2	1.2
Reaction time mean minus median	0.1	0.4	0.7	-0.4	0.4	0.5	0.9	-0.7
Reaction time mean minus median AUC	0.0	0.0	0.2	0.2	-0.2	-0.0	0.4	-0.1
Reaction time num false alarms	0.4	0.6	0.7	0.7	-0.7	-0.7	-0.8	0.8
Reaction time num false alarms AUC	0.8	1.3	1.6	1.0	-1.0	-1.1	-1.2	1.2
Reaction time trials correct on left	1.1	2.1	2.7	1.7	-1.7	-1.5	-1.2	1.2
Reaction time trials on left	1.1	2.1	2.8	1.7	-1.7	-1.5	-1.2	1.2
Reaction time mean	0.3	0.5	0.6	0.8	-0.8	-0.7	-0.6	0.6
Reaction time mean AUC	0.1	0.2	0.3	0.5	-0.5	-0.6	-0.4	0.4
Median of all reaction times	0.9	1.3	1.5	1.1	-1.1	-1.2	-1.2	1.1
Reaction time omissions	0.0	0.1	0.3	-0.0	0.0	0.5	0.1	-0.2
Reaction time false alarm rate	0.1	0.2	0.3	0.2	-0.2	-0.5	-0.5	0.6
Reaction time premature initiation rate	1.5	2.1	3.1	-1.2	1.2	1.8	1.6	-1.4
Reaction time premature initiations	0.4	0.8	1.3	-0.6	0.6	1.1	1.0	-0.9
Std. dev. reaction times	0.1	0.2	0.5	0.7	-0.7	-0.5	0.0	0.1
Reaction time trials completed	1.1	2.1	2.8	1.7	-1.7	-1.5	-1.2	1.2
Reaction time trials AUC	1.1	2.0	2.7	1.6	-1.6	-1.5	-1.2	1.1
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.4	0.4	0.0	0.1	-0.2
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.0	0.0	0.2	-0.2	-0.1
Latency to leave start box in cocaine runway	1.9	2.1	2.9	-1.5	1.5	0.8	1.6	-1.7
Latency to leave start box in cocaine runway, F	1.4	1.5	2.3	-1.2	1.2	0.8	1.4	-1.5
Latency to leave start box in cocaine runway, M	0.4	0.3	0.5	-0.7	0.7	-0.3	0.6	-0.5
Std. dev. time between licks in bursts	0.0	0.0	0.0	0.0	-0.0	-0.1	0.2	-0.2
Total sessions with >9 infusions	2.3	2.7	4.5	1.5	-1.5	-0.8	-2.1	2.0
Short access day 1 total inactive lever presses	0.2	0.3	0.7	-0.8	0.8	0.4	0.4	0.0
Short access day 10 total inactive lever presses	0.2	0.4	0.7	-0.6	0.6	-0.1	0.8	-0.7
Short access day 1 total infusions	0.5	0.7	1.9	0.3	-0.3	-0.2	-1.2	1.4
Short access day 10 total infusions	0.1	0.1	0.3	0.0	-0.0	0.6	-0.3	0.4
Short access total infusions	0.3	0.4	1.0	0.2	-0.2	0.4	-1.0	1.0
Short access day 1 locomotion	1.9	2.3	3.4	1.5	-1.5	-0.9	-1.7	1.8
Short access day 10 total locomotion	1.7	3.2	3.9	1.9	-1.9	-1.4	-2.0	1.7
Short access total locomotion	1.0	1.3	2.0	1.0	-1.0	-0.5	-1.4	1.4
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.1	-0.1	0.3	-0.5	0.3
Compulsive drug intake	1.0	1.1	2.4	0.9	-0.9	-1.6	-0.8	0.9
One hour access (shock baseline)	0.3	0.4	1.8	-0.3	0.3	1.3	-0.2	0.1
Social response proportion	0.4	0.5	0.8	0.6	-0.6	-0.8	-0.9	0.5
Social responses	0.8	1.0	1.7	-1.3	1.3	1.0	0.6	-0.4
Social time	0.1	0.2	0.6	-0.1	0.1	0.5	-0.8	0.3
Soleus weight	1.9	5.5	7.8	2.1	-2.1	-2.5	-2.8	2.2
Bone: stiffness	0.1	0.2	0.4	-0.4	0.4	-0.1	0.6	-0.6
Tibialis anterior weight	1.3	4.3	5.8	2.4	-2.4	-1.9	-2.0	1.4
Time to tail flick, vehicle, before self-admin	1.6	1.7	2.6	-1.3	1.3	0.2	1.6	-1.6
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.3	-0.5	0.5	0.2	0.5	-0.4
Time to tail flick, test, before self-admin	0.3	0.3	1.0	0.4	-0.4	-1.0	-0.3	0.5
Time to tail flick, test, after self-admin	0.4	0.4	0.7	-0.8	0.8	0.7	0.4	-0.4
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.6	0.5	-0.5	0.6	-0.8	0.6
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.6	0.6	0.6	-0.0	-0.2
Tibia length	0.9	2.4	4.1	2.0	-2.0	-1.1	-1.1	1.1
Ambulatory time before self-admin	0.2	0.4	0.5	-0.5	0.5	-0.6	0.7	-0.6
Ambulatory time after self-admin	1.4	1.6	2.3	-1.4	1.4	0.7	1.5	-1.1
Bone: tissue strength	0.1	0.1	0.4	0.2	-0.2	-0.7	-0.1	0.1
Total heroin consumption	0.1	0.1	0.4	0.0	-0.0	0.0	-0.4	0.6
Bone: trabecular number	0.1	0.1	0.3	0.1	-0.1	0.6	0.4	-0.1
Bone: trabecular spacing	0.1	0.1	0.3	-0.1	0.1	0.0	0.1	-0.6
Bone: trabecular thickness	0.1	0.2	0.7	-0.1	0.1	0.9	0.3	-0.1
Bone: trabecular tissue density	0.4	0.6	1.5	0.8	-0.8	-1.2	-0.5	0.0
Water consumed over 24 hours	0.2	0.2	0.8	0.2	-0.2	0.3	0.9	-0.4
Number of responses in last shaping day	0.8	0.9	2.4	-0.8	0.8	1.5	0.6	-0.5