Hub : Genes

Pkd2l2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Pkd2l2	0.03	0.02	1.1e-04	0.03	0.03	0.03	0.03	2.0e-04	2.6e-04	3.1e-04	3.8e-04
2	Liver	gene expression	Pkd2l2	0.03	0.02	3.9e-03	0.04	0.01	0.02	0.04	4.5e-05	1.0e-02	1.8e-03	8.8e-05
3	Adipose	gene expression	Pkd2l2	0.03	0.02	6.1e-04	0.04	0.02	0.03	0.04	1.8e-05	2.0e-03	2.9e-04	8.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.3	0.4	1.1	1.0	0.3	-0.4
Area under the delay curve	4.4	4.7	4.7	2.1	2.2	-2.2
BMI with tail	7.7	25.1	27.5	-4.5	-5.2	5.2
BMI without tail	5.4	11.1	12.6	-3.1	-3.6	3.4
Body weight	7.7	32.4	36.6	-4.9	-6.0	6.0
Weight adjusted by age	1.8	2.0	3.1	-1.8	-1.2	1.2
Bone surface	0.7	1.2	2.8	1.7	0.6	-0.6
Bone volume	0.4	0.8	2.0	1.4	0.3	-0.4
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.2	-0.1	-0.0
Number of licking bursts	1.2	1.4	2.7	1.6	0.8	-0.9
Context. condit. distance diff. score	0.0	0.1	0.2	0.4	-0.0	0.1
Locomotion velocity, session 1	0.7	0.7	0.7	-0.8	-0.8	0.9
Locomotion distance, session 1	0.0	0.0	0.0	0.1	-0.1	0.1
Locomotion velocity, session 2	0.9	1.0	1.2	-1.0	-1.0	1.1
Locomotion distance, session 2	0.5	0.7	0.9	0.9	0.7	-0.8
Locomotion velocity, session 3	0.3	0.4	0.5	-0.4	-0.7	0.7
Locomotion distance, session 3	0.1	0.1	0.4	0.6	0.2	-0.2
Stereotopy head waving bouts, day 3	2.1	2.5	2.9	1.4	1.7	-1.6
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.2	0.6	-0.5
Locomotion velocity, session 7	0.3	0.4	0.5	-0.3	-0.7	0.7
Locomotion distance, session 7	0.2	0.2	0.4	0.7	0.2	-0.4
Stereotopy head waving bouts, day 7	0.5	0.6	1.4	-1.2	-0.4	0.5
Stereotopy head waving duration, day 7	0.2	0.2	0.5	-0.7	-0.0	0.2
Locomotion velocity, session 8	0.2	0.2	0.5	-0.7	-0.3	0.3
Locomotion distance, session 8	0.0	0.1	0.2	0.4	0.1	-0.1
Degree of sensitization distance	0.2	0.2	0.2	-0.4	-0.4	0.4
Degree of sensitization stereotypy	0.3	0.3	0.8	-0.9	-0.1	0.3
Conditioned locomotion	0.1	0.1	0.1	0.4	-0.3	0.3
Cocaine response after cond. corrected	0.7	0.8	1.1	-0.6	-1.0	1.0
Cocaine response after cond. not corrected	0.0	0.0	0.1	0.2	-0.1	0.0
Cocaine response before conditioning	5.4	6.6	7.1	2.5	2.5	-2.7
Saline control response	0.9	1.2	1.5	1.0	1.2	-1.0
Bone: connectivity density	1.5	2.3	3.4	1.8	1.3	-1.3
Bone: cortical apparent density	1.3	1.7	2.3	0.9	1.5	-1.4
Bone: cortical area	2.9	4.3	6.2	2.5	1.8	-1.9
Bone: cortical porosity	0.9	1.0	1.2	-1.1	-0.9	0.9
Bone: cortical porosity	0.6	0.7	0.8	-0.9	-0.8	0.8
Bone: cortical thickness	2.2	3.6	4.9	2.2	1.7	-1.7
Bone: cortical thickness	0.4	0.5	0.9	1.0	0.4	-0.6
Bone: cortical tissue density	1.1	1.4	2.0	0.7	1.4	-1.3
Condit. Reinf. active minus inactive responses	2.1	2.3	2.8	1.4	1.7	-1.5
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.6	1.0	1.3	-1.2
Condit. Reinf. active responses	1.9	2.4	3.2	1.8	1.5	-1.3
Condit. Reinf. inactive responses	1.1	1.3	2.5	1.6	0.9	-0.9
Incentive salience index mean	1.8	2.2	2.8	1.2	1.7	-1.5
Condit. Reinf. lever presses	1.4	1.8	2.3	1.1	1.5	-1.4
Condit. Reinf. active minus inactive responses	3.8	4.7	5.2	2.0	2.3	-2.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.3	0.2	-0.0
Condit. Reinf. active responses	9.7	13.4	14.1	3.5	3.7	-3.7
Condit. Reinf. inactive responses	10.4	12.8	13.6	3.6	3.5	-3.7
Condit. Reinf. lever presses	2.3	3.1	3.6	1.9	1.7	-1.7
Condit. Reinf. lever reinforcers received	8.8	12.4	13.3	3.3	3.7	-3.6
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.4	-0.0	-0.2
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.4	0.2	0.1
Conditioned locomotion	0.1	0.1	0.1	0.3	0.2	-0.4
Patch foraging indifference point 0 sec	2.7	4.3	5.2	1.9	2.0	-2.3
Patch foraging indifference point AUC	3.5	4.0	4.4	1.9	2.1	-2.0
Delay disc. indifference point, 0s delay	1.6	1.7	1.9	1.4	1.3	-1.2
Delay disc. indifference point, 16s delay	5.4	5.5	5.7	2.3	2.3	-2.4
Delay disc. indifference point, 2s delay	0.5	0.6	0.6	0.6	0.8	-0.8
Delay disc. indifference point, 24s delay	0.7	0.7	0.8	0.9	0.7	-0.8
Delay disc. indifference point, 4s delay	0.7	0.7	0.9	0.8	0.9	-0.9
Delay disc. indifference point, 8s delay	5.9	6.1	6.3	2.5	2.5	-2.4
Indifference point function ln k	8.5	11.8	13.2	-3.4	-3.6	3.3
Indifference point function log k	8.5	11.8	13.2	-3.4	-3.6	3.3
Patch foraging total patch changes 0 sec	2.6	4.2	4.9	2.0	2.0	-2.2
Patch foraging total patch changes 12 sec	11.0	14.2	15.1	3.9	3.7	-3.7
Patch foraging total patch changes 18 sec	4.9	6.3	7.2	2.7	2.3	-2.5
Patch foraging total patch changes 24 sec	3.8	4.6	5.3	2.3	2.0	-2.1
Patch foraging total patch changes 6 sec	4.5	6.7	7.2	2.7	2.5	-2.6
Patch foraging time to switch 0 sec	0.1	0.1	0.2	-0.4	-0.3	0.4
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.1	-0.1	0.0
Patch foraging water rate 12 sec	0.6	0.9	1.3	-0.4	-1.2	1.0
Patch foraging water rate 18 sec	0.1	0.2	0.2	-0.4	-0.4	0.4
Patch foraging water rate 24 sec	0.2	0.2	0.4	-0.1	-0.5	0.6
Patch foraging water rate 6 sec	0.1	0.1	0.2	0.0	-0.5	0.4
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.0	0.7	1.0	-0.8
Distance traveled before self-admin	0.2	0.2	0.2	-0.5	0.4	-0.3
Distance traveled after self-admin	0.9	1.0	1.2	0.8	1.1	-1.1
Extensor digitorum longus weight	2.0	8.0	8.3	-2.7	-2.9	2.9
Bone: elastic displacement	1.1	1.2	1.6	-1.3	-1.0	1.0
Bone: elastic work	1.5	1.9	2.2	-1.5	-1.3	1.4
Bone: endosteal estimation	0.5	1.1	2.0	1.4	0.7	-0.7
Bone: endosteal perimeter	0.1	0.1	0.2	0.5	0.3	-0.3
Epididymis fat weight	4.5	10.4	11.2	-3.3	-3.1	3.2
Delta time in closed arm before/after self-admin	3.7	3.6	5.2	-2.3	-1.5	1.8
Delta time in open arm before/after self-admin	0.6	0.6	1.1	1.0	0.6	-0.7
Diff in mean of infusions in LGA sessions	0.9	1.0	1.3	-0.7	-1.1	1.1
Delay discount exponential model param	4.5	4.7	4.8	-2.2	-2.2	2.2
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.5	-0.2	0.1
Active lever presses in extinction session 6	2.4	2.3	3.1	1.8	1.3	-1.5
Bone: final force	1.2	1.9	2.3	1.5	1.3	-1.3
Bone: final moment	0.6	1.0	1.3	1.2	0.9	-0.9
Food consumed during 24 hour testing period	1.5	1.9	2.7	-0.8	-1.6	1.5
Glucose	8.1	12.3	12.5	-3.5	-3.5	3.4
Heart weight	3.8	5.3	6.3	-1.9	-2.5	2.5
Delay discount hyperbolic model param	4.0	4.2	4.3	-2.1	-2.0	2.1
Intermittent access intake day 1-15 change	0.4	0.4	0.6	-0.4	-0.7	0.8
Intermittent access intake escalation	0.2	0.2	0.3	0.0	-0.5	0.6
Intermittent access intake escalation 2	0.3	0.3	0.5	-0.3	-0.7	0.6
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	0.2	0.0	0.4
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.2	0.4	-0.4	0.4
Intermitt. access escalation Index	1.3	1.1	1.3	-1.0	-1.0	1.1
Intermittent access day 1 total infusions	0.4	0.4	0.6	0.5	0.6	-0.8
Intermittent access day 15 total infusions	0.2	0.2	0.5	0.7	0.3	-0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.5	0.2	-0.4
Intermittent access total infusions	0.0	0.0	0.0	0.1	0.1	-0.2
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.0	0.1	-0.2
Intermittent access day 15 total locomotion	2.2	2.4	2.9	-1.2	-1.7	1.7
Intermittent access total locomotion	0.9	1.0	1.1	-1.0	-1.1	0.9
Intermittent access standard deviation	0.1	0.1	0.3	-0.5	-0.1	0.2
Left kidney weight	0.2	0.7	1.0	-0.2	-1.0	1.0
Right kidney weight	0.2	0.6	0.9	0.0	-0.9	0.9
Cocaine induced anxiety	0.2	0.2	0.2	-0.5	-0.5	0.4
Post-drug Anxiety	0.1	0.1	0.2	0.5	0.2	-0.4
Baseline Anxiety	0.5	0.5	0.8	0.9	0.6	-0.6
Tail length	0.1	0.2	0.4	-0.1	-0.6	0.5
Length with tail	0.8	3.1	3.8	-1.5	-1.9	1.8
Length without tail	0.9	2.0	2.3	-1.3	-1.4	1.5
Times rat made contact with spout	0.2	0.3	0.3	0.4	-0.5	0.6
Lifetime Intake	0.0	0.0	0.0	-0.2	0.1	-0.2
Liver weight, left	0.0	0.0	0.0	-0.0	-0.1	0.0
Liver weight, right	1.1	1.9	2.0	1.4	1.3	-1.4
Locomotor activity	0.0	0.0	0.0	-0.0	0.2	-0.2
Locomotor testing distance	0.0	0.0	0.0	-0.2	0.1	-0.0
Locomotor testing rearing	0.5	0.8	0.9	1.0	0.9	-0.8
Locomotion in novel chamber	0.0	0.0	0.1	0.0	0.2	-0.1
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.0	-0.5	0.2
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	-0.4	0.0	-0.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.3	-0.1	0.1
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.7	-0.4	-0.3	0.9
Bouts of movement, locomotor time 1	2.0	2.2	3.4	1.8	1.5	-1.1
Total resting periods, locomotor time 1	1.7	1.9	2.8	1.7	1.4	-1.0
Rest time, locomotor task time 1	0.1	0.1	0.1	0.3	-0.2	0.3
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.2	-0.2	-0.0
Vertical activity count, locomotor time 1	0.6	0.7	1.0	-1.0	-0.8	0.6
Time >=10cm from walls, locomotor time 2	5.9	6.3	7.1	-2.7	-2.4	2.4
Bouts of movement, locomotor time 2	0.2	0.2	0.4	0.6	0.3	-0.4
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.4	0.1	-0.1
Rest time, locomotor task time 2	1.1	1.3	1.5	-1.2	-1.2	1.0
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.2	-0.1	-0.0
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.2	0.2	-0.2
Light reinforcement 1	2.0	3.6	4.5	2.1	1.8	-1.8
Light reinforcement 2	3.7	5.0	5.7	2.1	2.4	-2.2
Bone: marrow area	0.5	1.0	2.0	1.4	0.7	-0.7
Bone: maximum diameter	2.6	4.7	6.5	2.5	1.9	-2.0
Bone: maximum force	0.4	0.6	0.9	1.0	0.7	-0.7
Bone: maximum moment	0.1	0.2	0.3	0.6	0.3	-0.3
Mean time between licks in bursts	0.6	0.8	1.3	0.0	-1.2	1.0
Mean num. licks in bursts	1.5	1.7	1.9	-1.4	-1.3	1.3
Cd content in liver	0.0	0.0	0.0	0.0	0.2	-0.1
Co content in liver	0.4	0.5	0.6	-0.6	-0.7	0.8
Cu content in liver	4.7	5.7	6.8	2.1	2.4	-2.6
Fe content in liver	1.3	1.6	1.7	1.3	1.2	-1.3
K content in liver	0.3	0.3	0.5	0.4	0.6	-0.7
Mg content in liver	1.9	1.9	2.1	1.4	1.3	-1.5
Mn content in liver	0.4	0.5	0.6	-0.3	-0.8	0.8
Na content in liver	0.1	0.1	0.2	-0.1	0.4	-0.3
Rb content in liver	1.8	2.2	3.5	1.9	1.1	-1.4
Se content in liver	0.2	0.3	0.4	0.6	0.5	-0.4
Sr content in liver	1.0	0.9	1.3	0.4	1.1	-1.2
Zn content in liver	2.9	3.2	3.5	1.7	1.9	-1.8
Bone: minimum diameter	0.8	1.5	2.5	1.6	1.0	-1.0
Time in familiar zone, hab. session 1	0.4	0.4	0.5	-0.2	-0.7	0.7
Time in novel zone, hab. session 1	1.3	1.2	1.5	0.8	1.2	-1.2
Total zone transitions, hab. session 1	2.4	3.4	3.5	-1.8	-1.8	1.9
Total locomotion distance, hab. session 1	0.0	0.1	0.1	-0.3	0.1	0.2
Locomotion velocity, hab. session 1	0.0	0.1	0.2	-0.4	0.1	0.2
Time in familiar zone, hab. session 2	3.8	3.9	6.0	2.5	1.7	-1.7
Time in novel zone, hab. session 2	3.2	3.2	5.2	-2.3	-1.4	1.5
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.2	-0.4	0.4
Total locomotion distance, hab. session 2	0.4	0.5	0.8	0.9	0.5	-0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.6	0.2	-0.2
Novel to familiar place preference ratio	1.7	1.7	3.2	-1.8	-0.9	1.1
Novelty place preference	2.1	2.1	3.8	-2.0	-1.0	1.2
Time in novel zone, NPP test	1.8	1.8	3.3	-1.8	-0.9	1.2
Total zone transitions, NPP test	0.0	0.0	0.0	0.1	-0.2	0.1
Total locomotion distance, NPP test	0.5	0.6	0.9	1.0	0.7	-0.7
Locomotion velocity, NPP test	0.6	0.9	1.2	1.1	0.8	-0.8
Intraocular pressure	5.5	7.6	8.4	-2.5	-2.9	2.9
Delta distance traveled before/after self-admin	2.8	3.0	5.0	2.2	1.3	-1.5
Delta ambulatory time before/after self-admin	2.7	2.9	4.7	2.2	1.3	-1.5
Parametrial fat weight	0.8	1.6	3.7	-1.9	-0.9	0.6
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.2	0.2	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.4	0.6	-0.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	0.3	-0.2
Pavlov. Cond. index score	0.0	0.0	0.0	-0.2	0.1	-0.0
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	-0.0	0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.0	0.4	-0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.2	-0.4	0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.6	0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.1	0.1	0.3	-0.2
Pavlov. Cond. response bias	0.1	0.1	0.1	0.3	0.4	-0.3
Pavlov. Cond. lever latency	1.3	1.7	1.9	-1.1	-1.4	1.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.3	0.3	-0.2
Pavlov. Cond. change in total contacts	1.9	2.6	3.5	1.1	1.9	-1.7
Pavlov. Cond. index score	0.6	0.8	1.1	0.7	1.1	-0.9
Pavlov. Cond. latency score	0.6	0.7	1.1	0.5	1.0	-0.9
Pavlov. Cond. lever contacts	1.3	1.7	1.9	1.4	1.3	-1.3
Pavlov. Cond. magazine entry number	1.1	1.4	1.8	-0.9	-1.3	1.2
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.1	-0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	1.2	0.7	1.1	-0.9
Pavlov. Cond. response bias	2.3	3.1	3.2	1.8	1.8	-1.8
Time in closed arm before self-admin	0.8	0.9	1.3	-0.6	-1.1	1.0
Time in closed arm after self-admin	1.8	1.8	2.2	-1.5	-1.2	1.3
Time in open arm before self-admin	0.1	0.1	0.3	0.2	0.6	-0.2
Time in open arm after self-admin	0.3	0.4	0.9	1.0	0.2	-0.4
Bone: periosteal estimation	1.4	2.9	4.8	2.2	1.4	-1.4
Bone: periosteal perimeter	0.7	1.2	1.7	1.3	1.0	-1.0
Bone: post-yield work	0.2	0.2	0.3	0.5	0.5	-0.3
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.3	-0.1	0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	-0.4	-0.1	0.1
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.3	0.5	0.6	-0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	-0.4	-0.3	0.4
Progressive ratio test 2 breakpoint	0.3	0.3	0.4	-0.6	-0.5	0.5
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	-0.2	-0.3	0.3
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.2	-0.4	0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.2	-0.4	0.4
Sum of active levers in priming session hrs 5-6	3.9	3.8	4.6	1.6	2.1	-2.0
Progressive ratio	0.1	0.1	0.2	-0.0	0.3	-0.4
Food seeking constrained by brief footshock	0.2	0.2	0.3	0.3	0.5	-0.5
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.2	-0.0	0.2
Retroperitoneal fat weight	4.0	13.0	15.1	-3.9	-3.5	3.4
Reaction time number correct	1.6	2.3	3.1	-1.1	-1.7	1.6
Reaction time mean minus median	0.1	0.2	0.3	0.3	0.5	-0.5
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.2	-0.1	0.0
Reaction time num false alarms	1.0	1.3	2.4	-1.6	-0.9	0.9
Reaction time num false alarms AUC	1.6	2.2	3.8	-2.0	-1.2	1.2
Reaction time trials correct on left	1.6	2.3	3.1	-1.1	-1.7	1.6
Reaction time trials on left	1.6	2.3	3.1	-1.1	-1.8	1.6
Reaction time mean	0.6	0.8	1.5	-1.2	-0.7	0.7
Reaction time mean AUC	0.3	0.4	1.0	-1.0	-0.4	0.4
Median of all reaction times	1.2	1.7	2.9	-1.7	-1.1	1.0
Reaction time omissions	0.0	0.0	0.0	0.1	0.0	-0.2
Reaction time false alarm rate	0.4	0.6	1.6	-1.3	-0.3	0.3
Reaction time premature initiation rate	2.4	3.2	6.2	2.5	1.3	-1.3
Reaction time premature initiations	0.9	1.3	3.2	1.8	0.5	-0.7
Std. dev. reaction times	0.3	0.4	0.4	-0.7	-0.7	0.6
Reaction time trials completed	1.6	2.3	3.1	-1.1	-1.8	1.6
Reaction time trials AUC	1.6	2.3	3.1	-1.1	-1.8	1.6
Run reversals in cocaine runway, females	0.5	0.5	0.8	0.4	0.9	-0.7
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.3	0.3	-0.2
Latency to leave start box in cocaine runway	1.9	2.1	3.2	1.8	1.1	-1.4
Latency to leave start box in cocaine runway, F	1.3	1.4	3.2	1.8	0.6	-0.8
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	-0.3	0.4	-0.5
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.3	0.1	-0.0
Total sessions with >9 infusions	1.0	1.1	1.8	-1.4	-0.8	1.0
Short access day 1 total inactive lever presses	0.4	0.4	0.6	0.5	0.6	-0.8
Short access day 10 total inactive lever presses	0.4	0.4	1.1	1.1	0.1	-0.2
Short access day 1 total infusions	0.3	0.3	0.6	-0.8	0.4	-0.3
Short access day 10 total infusions	0.0	0.0	0.0	-0.0	0.2	-0.2
Short access total infusions	0.2	0.2	0.3	-0.2	0.6	-0.6
Short access day 1 locomotion	1.3	1.4	1.6	-1.3	-1.1	1.2
Short access day 10 total locomotion	2.6	2.9	3.2	-1.7	-1.6	1.8
Short access total locomotion	0.9	1.0	1.5	-1.2	-0.8	0.9
One hour access (0.3 mA shock)	0.2	0.2	0.4	-0.7	-0.4	0.3
Compulsive drug intake	0.7	0.7	1.2	-1.1	-0.6	0.7
One hour access (shock baseline)	0.0	0.0	0.1	0.1	0.1	-0.2
Social response proportion	1.0	1.1	1.8	-1.3	-1.0	0.8
Social responses	0.9	1.2	2.0	0.3	1.2	-1.4
Social time	0.1	0.2	0.5	-0.7	-0.1	0.0
Soleus weight	1.6	4.8	7.8	-2.8	-1.8	1.8
Bone: stiffness	0.6	1.0	1.5	1.2	0.9	-0.9
Tibialis anterior weight	1.1	3.8	4.9	-1.3	-2.2	2.2
Time to tail flick, vehicle, before self-admin	3.1	3.1	3.9	1.6	1.7	-2.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	0.3	0.4	-0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.3	-0.6	-0.2	0.1
Time to tail flick, test, after self-admin	1.5	1.5	2.2	0.6	1.5	-1.4
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.0	-0.5	-0.9	1.0
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	0.0	0.7	-0.6
Tibia length	1.1	3.2	3.8	-1.4	-1.9	2.0
Ambulatory time before self-admin	0.1	0.1	0.2	-0.5	0.2	-0.2
Ambulatory time after self-admin	0.8	0.9	1.0	0.8	0.9	-1.0
Bone: tissue strength	0.0	0.0	0.1	-0.1	-0.2	0.2
Total heroin consumption	0.2	0.2	0.7	-0.8	-0.2	-0.2
Bone: trabecular number	0.2	0.3	0.9	1.0	0.1	-0.2
Bone: trabecular spacing	0.0	0.0	0.1	-0.0	0.2	-0.2
Bone: trabecular thickness	0.2	0.3	0.7	0.8	0.2	-0.3
Bone: trabecular tissue density	0.2	0.2	0.2	-0.5	-0.4	0.5
Water consumed over 24 hours	0.2	0.3	0.7	0.8	-0.3	0.2
Number of responses in last shaping day	1.1	1.1	1.7	1.3	1.1	-0.6