Pitpnc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Pitpnc1	0.04	0.02	1.2e-03	0	0.02	0.01	0.01	2.4e-01	1.2e-03	8.3e-03	2.0e-02
2	Liver	gene expression	Pitpnc1	0.11	0.05	8.9e-09	0.04	0.05	0.06	0.06	5.6e-05	1.9e-06	4.0e-07	8.5e-07
3	IL	gene expression	Pitpnc1	0.51	0.15	1.5e-04	0.08	0.11	0.12	0.13	5.2e-03	1.4e-03	7.6e-04	5.0e-04
4	Brain	gene expression	Pitpnc1	0.2	0.1	1.5e-07	0.04	0.07	0.08	0.07	6.7e-05	5.2e-07	8.6e-08	3.9e-07
5	RMTg	intron excision ratio	chr10_92673609_92683748	0.21	0.12	5.5e-03	0.1	0.03	0.08	0.16	1.4e-03	5.1e-02	3.9e-03	5.9e-05
6	LHb	gene expression	Pitpnc1	0.29	0.13	7.2e-03	0.1	0.09	0.05	0.11	2.6e-03	4.3e-03	2.7e-02	1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.1	0.1	0.3	0.4	-0.5	-0.2	-0.1	0.5	-0.0
Area under the delay curve	1.1	1.3	1.8	-0.9	0.9	-1.3	-1.3	1.3	-1.0
BMI with tail	0.8	2.7	5.2	-1.6	-0.9	-1.4	-1.0	2.2	2.3
BMI without tail	1.2	3.7	6.9	-1.4	-1.9	-1.4	-1.1	2.6	2.5
Body weight	0.6	2.7	6.1	0.0	-2.5	-0.5	-0.3	2.5	1.9
Weight adjusted by age	0.5	0.8	1.1	-0.8	1.0	-0.9	-1.0	0.4	-1.1
Bone surface	1.9	3.4	8.6	2.9	-2.3	1.9	1.6	-0.3	-0.4
Bone volume	0.8	1.5	3.9	2.0	-1.9	0.9	0.8	0.3	-0.3
Breakpoint value in progressive ratio session	0.7	0.9	2.0	-0.1	1.3	0.7	0.1	-1.4	-0.9
Number of licking bursts	0.1	0.1	0.5	0.4	-0.2	0.2	0.1	-0.7	-0.2
Context. condit. distance diff. score	0.0	0.0	0.1	-0.1	0.1	-0.4	-0.1	-0.2	-0.2
Locomotion velocity, session 1	0.2	0.2	0.6	0.6	-0.5	0.7	0.0	0.5	-0.0
Locomotion distance, session 1	0.2	0.3	1.1	0.2	-0.1	0.2	-0.7	1.0	-0.4
Locomotion velocity, session 2	2.2	2.5	5.0	1.9	-0.8	2.2	1.1	-2.0	-0.8
Locomotion distance, session 2	0.3	0.5	0.9	0.5	0.4	0.8	-0.1	-0.9	-1.0
Locomotion velocity, session 3	1.4	1.6	3.2	-1.0	1.6	-0.8	-1.8	0.2	-1.4
Locomotion distance, session 3	0.5	0.6	2.4	0.4	0.5	-0.0	-0.4	-0.6	-1.5
Stereotopy head waving bouts, day 3	1.1	1.3	2.1	-1.4	1.5	-1.0	-1.3	1.0	-0.1
Stereotopy head waving duration, day 3	1.4	1.7	3.0	-1.4	1.7	-1.1	-1.5	1.0	-0.6
Locomotion velocity, session 7	0.1	0.2	0.7	-0.1	-0.1	0.4	0.3	-0.1	0.8
Locomotion distance, session 7	0.1	0.1	0.3	0.1	-0.6	-0.1	0.4	-0.2	0.2
Stereotopy head waving bouts, day 7	1.6	1.8	6.4	-0.7	2.5	-0.3	-1.0	-0.9	-1.4
Stereotopy head waving duration, day 7	1.9	2.3	8.2	-0.6	2.9	-0.1	-0.9	-1.3	-1.7
Locomotion velocity, session 8	0.9	1.1	2.3	1.4	-0.7	1.5	1.1	-0.8	-0.1
Locomotion distance, session 8	0.2	0.3	0.6	0.8	-0.4	0.7	0.2	-0.7	-0.4
Degree of sensitization distance	0.6	0.6	1.6	0.1	-0.9	0.4	0.9	0.5	1.3
Degree of sensitization stereotypy	1.6	1.7	4.9	-0.4	2.2	0.0	-0.8	-1.6	-1.5
Conditioned locomotion	0.1	0.1	0.5	0.1	-0.4	0.0	0.5	-0.1	0.7
Cocaine response after cond. corrected	0.1	0.1	0.4	-0.2	0.6	-0.2	0.0	-0.1	-0.6
Cocaine response after cond. not corrected	0.7	0.9	1.9	0.6	1.0	0.7	0.3	-1.4	-1.2
Cocaine response before conditioning	1.1	1.3	2.3	1.0	1.0	1.0	-0.3	-1.5	-1.5
Saline control response	0.2	0.3	0.9	-0.3	-0.2	0.3	0.3	-0.6	1.0
Bone: connectivity density	0.3	0.4	1.1	1.1	-0.6	0.6	0.7	0.2	-0.3
Bone: cortical apparent density	4.9	6.7	12.3	-3.5	2.1	-3.5	-2.6	2.0	0.3
Bone: cortical area	0.4	0.6	1.5	0.1	-0.9	-0.6	-1.2	0.8	0.1
Bone: cortical porosity	4.1	4.4	8.2	2.9	-1.5	2.7	1.6	-2.5	-0.7
Bone: cortical porosity	1.8	2.0	4.3	2.1	-1.2	1.6	0.5	-1.5	-1.0
Bone: cortical thickness	6.8	11.3	21.8	-4.2	2.6	-4.0	-4.7	2.1	-0.2
Bone: cortical thickness	2.0	2.3	4.8	-2.2	1.2	-1.7	-2.1	0.3	0.4
Bone: cortical tissue density	4.7	6.5	12.0	-3.5	2.1	-3.4	-2.5	2.0	0.4
Condit. Reinf. active minus inactive responses	1.3	1.5	3.8	2.0	-1.0	1.3	0.3	-1.0	-1.2
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.9	1.4	-0.5	1.0	0.6	-1.1	-0.8
Condit. Reinf. active responses	1.5	1.8	5.0	2.2	-1.4	1.6	0.4	-0.7	-1.0
Condit. Reinf. inactive responses	0.4	0.5	1.2	1.1	-1.0	0.8	0.0	0.5	-0.3
Incentive salience index mean	1.1	1.4	3.2	1.8	-1.0	1.4	0.4	-1.2	-0.8
Condit. Reinf. lever presses	0.3	0.4	1.5	0.7	-0.4	0.8	0.2	-1.2	-0.0
Condit. Reinf. active minus inactive responses	2.1	2.7	7.4	2.7	-1.2	1.5	0.4	-1.4	-1.8
Condit. Reinf. active-inactive response ratio	1.6	1.9	4.4	2.1	-1.1	1.4	0.8	-1.4	-1.1
Condit. Reinf. active responses	2.1	2.9	8.7	3.0	-1.7	1.7	0.6	-0.9	-1.2
Condit. Reinf. inactive responses	0.5	0.6	1.6	1.3	-1.2	0.6	-0.3	0.4	-0.2
Condit. Reinf. lever presses	1.0	1.3	3.3	1.8	-1.3	0.9	0.4	-1.4	-0.5
Condit. Reinf. lever reinforcers received	1.8	2.6	7.7	2.8	-1.7	1.6	0.6	-0.8	-1.0
Conditioned reinforcement - actives	0.2	0.3	0.6	-0.1	-0.7	-0.4	-0.8	0.5	0.0
Conditioned reinforcement - inactives	0.2	0.4	1.0	0.6	-1.0	0.6	0.3	0.6	0.2
Conditioned locomotion	0.4	0.5	2.4	0.5	-1.5	0.1	0.3	0.4	0.5
Patch foraging indifference point 0 sec	0.8	1.4	5.5	1.1	-2.3	0.0	0.0	1.3	0.5
Patch foraging indifference point AUC	0.1	0.2	0.7	0.5	-0.8	0.4	0.1	0.3	-0.1
Delay disc. indifference point, 0s delay	0.5	0.6	1.2	-0.8	1.1	-0.8	-0.6	0.6	-0.5
Delay disc. indifference point, 16s delay	1.2	1.3	2.2	-1.1	0.5	-1.5	-1.4	1.5	-0.5
Delay disc. indifference point, 2s delay	0.4	0.4	1.3	0.1	-0.2	-0.5	-0.3	1.1	-0.8
Delay disc. indifference point, 24s delay	1.3	1.4	3.8	-0.8	-0.9	-1.3	-1.1	1.9	0.6
Delay disc. indifference point, 4s delay	1.0	1.0	2.8	-0.4	1.7	-0.6	-0.9	-0.1	-1.4
Delay disc. indifference point, 8s delay	1.4	1.6	2.3	-1.4	1.1	-1.5	-1.3	1.5	-0.7
Indifference point function ln k	0.3	0.6	1.3	-0.6	0.9	-0.9	-1.1	-0.1	-0.5
Indifference point function log k	0.3	0.6	1.3	-0.6	0.9	-0.9	-1.1	-0.1	-0.5
Patch foraging total patch changes 0 sec	0.7	1.3	4.9	1.2	-2.2	0.2	0.1	1.3	0.4
Patch foraging total patch changes 12 sec	1.9	2.4	7.8	1.8	-2.8	1.1	1.2	0.6	0.6
Patch foraging total patch changes 18 sec	0.4	0.6	1.6	0.9	-1.3	0.9	0.5	0.1	0.2
Patch foraging total patch changes 24 sec	0.5	0.9	2.5	0.7	-1.6	0.2	-0.5	1.5	-0.1
Patch foraging total patch changes 6 sec	1.0	1.5	5.4	1.4	-2.3	0.6	0.3	0.9	0.2
Patch foraging time to switch 0 sec	0.1	0.2	0.4	-0.6	0.5	-0.0	0.6	-0.4	0.3
Patch foraging water rate 0 sec	0.5	1.0	3.6	0.9	-1.9	0.2	0.1	0.9	0.8
Patch foraging water rate 12 sec	0.4	0.8	2.1	-0.9	0.8	-1.0	-1.4	0.8	-0.1
Patch foraging water rate 18 sec	0.2	0.3	1.1	-0.3	-0.0	-0.8	-1.1	0.3	-0.3
Patch foraging water rate 24 sec	0.2	0.2	0.9	0.1	0.6	0.0	-0.2	-0.3	-0.9
Patch foraging water rate 6 sec	0.4	0.5	1.2	-0.7	0.7	-0.6	-1.1	0.8	-0.1
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.7	-0.8	0.5	-0.8	-0.7	0.8	-0.0
Distance traveled before self-admin	0.9	1.2	3.2	-0.1	1.8	0.1	-0.6	-0.9	-1.7
Distance traveled after self-admin	0.8	1.0	2.3	0.9	0.4	0.7	-0.0	-1.5	-1.5
Extensor digitorum longus weight	1.4	5.4	10.6	-3.0	1.0	-1.9	-0.9	3.3	2.7
Bone: elastic displacement	1.2	1.4	3.2	-1.1	1.6	-0.9	-1.8	0.2	-0.9
Bone: elastic work	0.4	0.6	1.1	-0.6	-0.3	-0.9	-1.0	0.8	0.7
Bone: endosteal estimation	10.2	22.5	44.4	6.7	-5.5	5.2	5.2	-2.6	0.5
Bone: endosteal perimeter	7.8	16.7	36.5	6.0	-5.0	4.3	4.2	-1.5	-0.1
Epididymis fat weight	0.3	1.1	2.9	-0.8	-1.0	-0.8	0.3	1.0	1.7
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	0.1	-0.4	0.3	0.7	0.0	0.3
Delta time in open arm before/after self-admin	0.9	0.9	1.2	-0.9	1.1	-1.1	-1.0	0.9	-0.7
Diff in mean of infusions in LGA sessions	0.7	0.8	2.3	-1.5	1.0	-0.8	-0.6	-0.3	0.7
Delay discount exponential model param	0.8	0.9	1.6	0.6	-0.6	1.1	1.1	-1.3	0.9
Extinction: sum of active levers before priming	0.3	0.4	0.6	-0.7	0.7	-0.8	-0.5	0.5	0.4
Active lever presses in extinction session 6	0.2	0.2	0.3	0.6	-0.6	0.3	0.3	-0.4	0.0
Bone: final force	0.3	0.5	2.6	0.7	-1.6	0.2	-0.2	0.2	0.2
Bone: final moment	0.3	0.6	2.6	0.8	-1.6	0.2	-0.2	0.1	0.2
Food consumed during 24 hour testing period	0.7	1.0	3.3	-0.3	-1.2	0.2	0.3	1.0	1.8
Glucose	0.9	1.5	4.3	-1.1	2.1	-0.5	-1.1	-0.4	-1.3
Heart weight	1.0	1.5	3.0	-1.3	0.6	-1.6	-1.7	1.1	-0.4
Delay discount hyperbolic model param	0.7	0.8	1.4	0.6	-0.6	1.0	0.9	-1.2	0.9
Intermittent access intake day 1-15 change	0.4	0.9	2.0	0.8	-0.5	0.8	1.3	-0.5	1.4
Intermittent access intake escalation	0.4	0.9	1.6	0.9	-0.8	0.8	1.2	-0.4	1.3
Intermittent access intake escalation 2	1.9	2.2	4.1	1.3	-1.7	1.1	1.8	-0.3	2.0
Intermitt. access day 1 inactive lever presses	0.3	1.1	2.2	1.4	-0.7	1.5	1.1	-0.6	0.5
Intermitt. access day 15 inactive lever presses	0.5	1.1	2.2	0.4	-1.1	1.0	1.3	0.2	1.5
Intermitt. access escalation Index	0.6	0.9	2.6	-0.4	1.6	-0.2	-0.5	-1.2	-0.8
Intermittent access day 1 total infusions	0.4	0.6	2.6	0.3	0.1	-0.1	-1.1	0.1	-1.6
Intermittent access day 15 total infusions	0.1	0.2	0.5	0.6	-0.7	0.1	-0.1	0.3	0.1
Intermittent access terminal intake (last 3 days)	0.8	1.0	2.8	1.4	-1.7	0.8	0.7	0.2	0.4
Intermittent access total infusions	0.4	0.5	1.1	1.1	-1.0	0.4	-0.2	0.3	-0.8
Intermittent access day 1 locomotion	0.3	0.4	1.4	0.7	-1.2	0.2	-0.5	-0.1	-0.6
Intermittent access day 15 total locomotion	0.7	1.3	4.4	1.5	-2.1	0.8	0.6	-0.0	0.6
Intermittent access total locomotion	1.2	1.5	6.2	1.5	-2.5	0.6	0.0	0.1	0.0
Intermittent access standard deviation	0.2	0.4	0.7	0.8	-0.8	0.6	0.7	0.1	0.5
Left kidney weight	0.1	0.6	1.7	-0.5	0.7	-0.5	-1.3	0.0	-0.9
Right kidney weight	0.2	1.0	2.2	-0.8	1.0	-1.1	-1.5	0.2	-1.0
Cocaine induced anxiety	0.3	0.4	1.0	0.3	0.8	-0.1	-0.5	-0.8	-1.0
Post-drug Anxiety	0.3	0.3	0.5	-0.4	0.7	-0.5	-0.7	-0.1	-0.7
Baseline Anxiety	1.1	1.3	2.7	-1.7	-0.4	-1.2	-0.6	1.4	1.1
Tail length	0.7	2.8	10.5	1.6	-3.2	1.0	1.0	0.4	1.2
Length with tail	0.6	2.4	6.7	2.1	-2.6	1.3	1.1	0.6	0.5
Length without tail	0.1	0.2	0.8	0.3	-0.4	0.1	0.3	0.9	0.2
Times rat made contact with spout	0.7	0.8	3.0	0.9	-0.5	1.7	0.7	-0.5	0.5
Lifetime Intake	0.4	0.5	0.9	0.7	-1.0	0.2	-0.6	0.5	-0.9
Liver weight, left	2.3	3.8	8.2	2.9	-1.7	2.5	1.6	-1.6	-0.3
Liver weight, right	0.4	0.7	1.9	-0.9	1.1	-0.4	-1.4	0.2	-0.5
Locomotor activity	0.3	0.5	1.4	0.5	-0.1	-0.1	-1.0	-0.8	-1.2
Locomotor testing distance	0.3	0.5	1.0	0.6	0.0	0.2	-0.9	-0.9	-1.0
Locomotor testing rearing	1.0	2.1	4.6	1.6	-0.6	1.9	1.1	-2.1	0.5
Locomotion in novel chamber	0.6	0.7	1.5	0.6	0.8	0.9	0.4	-1.0	-1.2
Locomotion in novel chamber post-restriction	0.6	1.0	2.1	1.4	-1.1	1.1	1.1	0.2	-0.5
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	0.0	0.3	0.1	0.4	-0.0	-0.4
Change in fecal boli incidents, locomotor task	0.9	0.9	2.4	-0.4	-0.7	-0.9	-0.3	1.6	1.1
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.9	0.1	1.0	0.4	-0.1	-1.4	-1.1
Bouts of movement, locomotor time 1	0.7	0.8	1.4	-1.2	-0.0	-0.8	-0.3	1.0	1.2
Total resting periods, locomotor time 1	0.7	0.8	1.6	-1.1	-0.1	-0.8	-0.1	1.2	1.3
Rest time, locomotor task time 1	0.2	0.2	0.5	-0.2	0.6	0.2	0.7	0.3	0.7
Distance moved, locomotor task time 1	0.2	0.2	0.6	-0.2	-0.8	-0.0	0.0	0.3	0.8
Vertical activity count, locomotor time 1	0.0	0.1	0.4	0.1	-0.6	0.1	0.1	0.0	0.5
Time >=10cm from walls, locomotor time 2	0.7	1.1	2.2	0.4	0.2	1.3	1.3	-1.5	0.8
Bouts of movement, locomotor time 2	0.8	1.2	3.0	-1.7	0.9	-1.0	-0.6	0.9	1.2
Total resting periods, locomotor time 2	0.7	1.2	3.0	-1.7	1.2	-1.1	-0.8	0.8	0.6
Rest time, locomotor task time 2	1.6	2.0	4.8	-1.8	2.2	-1.4	-1.0	0.6	-1.0
Distance moved, locomotor task time 2	1.3	1.6	3.9	0.6	-1.1	1.3	1.3	-0.8	2.0
Vertical activity count, locomotor time 2	1.5	2.1	4.3	1.2	-1.5	1.4	1.4	-0.7	2.1
Light reinforcement 1	1.4	3.3	5.3	-2.3	0.7	-2.3	-2.2	2.0	0.6
Light reinforcement 2	1.8	2.8	4.9	-1.8	1.0	-1.9	-1.9	2.2	-0.4
Bone: marrow area	10.2	22.3	43.7	6.6	-5.4	5.2	5.2	-2.6	0.5
Bone: maximum diameter	1.4	2.6	7.8	2.8	-2.2	1.3	0.8	-0.1	-1.0
Bone: maximum force	0.5	0.8	3.1	0.7	-1.8	-0.2	-0.6	1.0	0.1
Bone: maximum moment	0.5	0.9	3.4	0.8	-1.8	-0.2	-0.5	0.9	0.2
Mean time between licks in bursts	0.2	0.4	1.0	-0.5	-0.5	-0.5	0.3	1.0	0.9
Mean num. licks in bursts	0.1	0.2	0.6	-0.3	0.1	0.3	-0.0	0.8	0.5
Cd content in liver	0.6	0.7	2.8	-0.0	-0.6	0.3	1.0	0.0	1.7
Co content in liver	0.3	0.4	1.6	-0.7	1.3	-0.3	-0.4	-0.1	-0.2
Cu content in liver	0.1	0.1	0.2	0.5	-0.4	0.3	0.4	0.1	0.3
Fe content in liver	1.2	1.4	4.2	1.3	0.2	0.8	0.3	-2.0	-1.4
K content in liver	0.3	0.3	1.4	0.5	0.2	0.2	-0.1	-0.4	-1.2
Mg content in liver	0.0	0.0	0.1	-0.3	0.2	-0.3	-0.2	-0.0	-0.2
Mn content in liver	0.5	0.5	2.2	0.3	0.3	-0.3	-0.7	-0.3	-1.5
Na content in liver	1.2	1.2	5.0	0.3	1.1	0.0	-0.6	-0.8	-2.2
Rb content in liver	0.6	0.8	1.5	-0.2	0.8	-0.8	-0.7	-1.1	-1.2
Se content in liver	2.9	3.4	6.3	-1.1	2.5	-1.5	-2.2	0.4	-2.4
Sr content in liver	0.5	0.4	1.2	0.0	-0.9	0.4	0.2	0.5	1.1
Zn content in liver	0.5	0.5	1.7	0.0	1.3	0.1	-0.6	0.1	-1.1
Bone: minimum diameter	4.4	8.1	20.4	3.9	-4.5	2.2	2.6	-0.6	0.8
Time in familiar zone, hab. session 1	1.0	0.9	2.0	1.0	-1.4	0.5	1.2	0.1	0.8
Time in novel zone, hab. session 1	0.7	0.7	1.5	-1.1	1.2	-0.4	-1.2	0.4	-0.1
Total zone transitions, hab. session 1	0.1	0.2	0.4	-0.1	-0.7	-0.0	-0.5	0.6	0.4
Total locomotion distance, hab. session 1	0.2	0.4	1.0	0.1	-1.0	0.3	-0.5	0.7	0.5
Locomotion velocity, hab. session 1	0.2	0.3	1.0	0.3	-1.0	0.6	-0.1	0.4	0.4
Time in familiar zone, hab. session 2	1.8	1.9	3.4	1.8	-1.2	1.7	1.5	-1.1	-0.1
Time in novel zone, hab. session 2	1.3	1.3	2.2	-1.5	1.0	-1.4	-1.1	1.2	0.0
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.2	-0.3	0.4	-0.2	0.2	0.5
Total locomotion distance, hab. session 2	0.6	0.8	2.1	-0.4	-1.0	0.0	-0.4	1.5	1.0
Locomotion velocity, hab. session 2	0.6	0.8	2.5	-0.5	-0.9	-0.0	-0.5	1.6	1.0
Novel to familiar place preference ratio	0.2	0.2	0.6	0.6	-0.8	-0.0	0.0	0.3	0.3
Novelty place preference	0.1	0.1	0.3	0.5	-0.6	0.0	-0.0	0.1	0.3
Time in novel zone, NPP test	0.1	0.1	0.3	0.6	-0.4	0.2	-0.0	-0.1	0.1
Total zone transitions, NPP test	0.5	0.7	2.1	-0.6	0.1	-0.6	-1.5	0.9	-0.6
Total locomotion distance, NPP test	0.3	0.4	1.3	0.4	-1.1	0.6	-0.0	0.6	0.4
Locomotion velocity, NPP test	0.4	0.6	2.2	-0.5	-0.7	-0.3	-0.9	1.5	0.3
Intraocular pressure	0.7	1.0	2.0	-0.7	0.8	-0.5	-1.3	1.4	-0.8
Delta distance traveled before/after self-admin	0.1	0.1	0.3	0.1	-0.6	-0.1	-0.4	-0.4	0.1
Delta ambulatory time before/after self-admin	0.2	0.3	1.1	0.4	-1.1	-0.2	-0.2	0.1	0.5
Parametrial fat weight	0.4	0.9	2.2	0.6	-1.1	0.6	1.5	0.5	0.9
Pavlov. Cond. lever latency	0.3	0.4	0.9	-0.5	0.2	-0.8	0.6	0.9	0.6
Pavlov. Cond. magazine entry latency	0.6	0.8	1.5	1.2	-1.0	1.0	-0.1	-0.8	-0.9
Pavlov. Cond. change in total contacts	0.8	0.8	1.7	1.2	-0.9	1.3	-0.3	-0.9	-0.6
Pavlov. Cond. index score	0.6	0.7	1.1	1.0	-0.6	1.0	-0.4	-0.9	-1.0
Pavlov. Cond. latency score	0.5	0.6	1.0	0.8	-0.3	0.9	-0.5	-0.9	-1.0
Pavlov. Cond. lever contacts	0.5	0.6	1.3	0.7	-0.5	1.2	0.0	-1.2	-0.1
Pavlov. Cond. magazine entry number	0.6	0.7	1.4	-1.0	0.8	-0.7	0.3	0.8	1.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.1	0.3	-1.1	-0.7	-0.6	0.9	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.2	1.0	-0.6	0.9	-0.5	-0.8	-1.1
Pavlov. Cond. response bias	0.9	1.1	1.8	1.3	-1.1	1.1	-0.2	-1.0	-1.0
Pavlov. Cond. lever latency	0.4	0.5	1.1	-1.0	0.3	-0.4	-0.1	1.0	0.9
Pavlov. Cond. magazine entry latency	1.0	1.2	3.3	-0.7	1.8	-0.7	-0.3	-1.1	-1.3
Pavlov. Cond. change in total contacts	0.9	1.4	3.1	1.6	0.1	1.0	0.7	-1.8	-1.2
Pavlov. Cond. index score	0.7	0.9	2.7	0.8	0.4	0.4	0.2	-1.6	-1.3
Pavlov. Cond. latency score	0.9	1.2	3.6	0.8	0.7	0.3	0.1	-1.9	-1.6
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.7	-0.3	0.1	-0.1	-0.8	-0.7
Pavlov. Cond. magazine entry number	1.5	1.9	4.8	0.7	-2.2	0.7	0.6	1.5	1.7
Pavlov. Cond. intertrial magazine entries	3.2	4.8	11.0	1.9	-3.3	1.6	1.9	1.7	2.3
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	2.7	0.8	0.6	0.3	0.2	-1.6	-1.4
Pavlov. Cond. response bias	0.2	0.3	0.8	0.6	0.0	0.1	-0.1	-0.9	-0.9
Time in closed arm before self-admin	0.1	0.1	0.4	0.1	-0.1	-0.1	-0.6	-0.6	-0.2
Time in closed arm after self-admin	0.4	0.4	0.6	0.5	-0.4	0.8	0.8	-0.7	0.4
Time in open arm before self-admin	0.3	0.3	1.3	-0.6	1.1	0.0	-0.1	-0.4	-0.1
Time in open arm after self-admin	0.4	0.4	1.1	-0.5	1.1	-0.4	-0.5	0.5	-0.7
Bone: periosteal estimation	4.1	8.6	19.0	4.4	-4.2	2.8	2.4	-1.0	0.4
Bone: periosteal perimeter	1.4	2.4	7.3	2.7	-1.9	1.4	0.8	-0.5	-0.9
Bone: post-yield work	1.1	1.6	2.7	1.6	-1.6	1.1	1.5	-0.9	0.2
Progressive ratio test 1 active lever presses	0.4	0.4	1.7	0.3	-1.3	-0.2	-0.8	0.4	-0.3
Progressive ratio test 1 breakpoint	0.4	0.5	2.1	0.4	-1.4	-0.2	-0.7	0.5	-0.1
Progressive ratio test 1 inactive lever presses	0.6	0.8	2.8	1.2	-1.7	0.7	0.1	0.1	0.1
Progressive ratio test 2 active lever presses	0.5	0.6	1.1	0.9	-1.1	0.2	-0.3	0.6	-0.9
Progressive ratio test 2 breakpoint	0.6	0.6	1.5	1.1	-1.2	0.4	-0.2	0.6	-0.8
Progressive ratio test 2 inactive lever presses	0.4	0.7	2.2	-0.1	-0.8	-0.5	-0.8	1.5	-0.2
Incentive Sensitization - Responses	0.3	0.4	0.8	0.9	-0.4	0.7	0.3	0.4	-0.8
Incentive Sensitization - Breakpoint	0.4	0.5	1.1	1.0	-0.4	0.8	0.5	0.3	-0.8
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.9	-0.6	0.7	-0.7	-0.9	-0.8	-0.4
Progressive ratio	0.1	0.2	0.8	0.3	0.3	0.2	0.4	0.1	-0.9
Food seeking constrained by brief footshock	5.4	6.6	9.0	2.7	-3.0	2.9	3.0	-1.7	1.7
Seeking ratio, punishment vs. effort	1.3	1.8	3.9	1.4	-2.0	1.3	1.1	-0.9	1.2
Retroperitoneal fat weight	0.5	2.1	6.9	-0.4	-2.0	-0.1	1.0	0.9	2.6
Reaction time number correct	0.6	1.1	1.8	-1.0	0.9	-1.3	-1.4	0.8	-0.9
Reaction time mean minus median	0.1	0.2	0.6	-0.5	0.1	-0.1	0.7	-0.2	0.8
Reaction time mean minus median AUC	0.1	0.3	0.7	-0.8	0.3	-0.8	-0.5	0.2	-0.2
Reaction time num false alarms	0.8	1.1	2.6	1.6	-0.6	1.1	-0.3	-0.5	-1.4
Reaction time num false alarms AUC	0.7	1.0	2.8	1.7	-1.0	1.0	-0.1	-0.3	-1.1
Reaction time trials correct on left	0.6	1.1	1.8	-1.0	0.9	-1.3	-1.4	0.8	-0.9
Reaction time trials on left	0.6	1.1	1.7	-1.0	0.8	-1.3	-1.3	0.8	-0.8
Reaction time mean	0.2	0.3	1.0	0.2	0.1	0.0	0.4	-1.0	-0.7
Reaction time mean AUC	0.2	0.3	1.6	0.1	0.0	0.1	0.5	-1.3	-0.4
Median of all reaction times	0.3	0.4	1.3	0.3	0.0	-0.0	0.2	-1.1	-1.0
Reaction time omissions	0.5	0.7	1.4	0.2	-1.2	0.1	0.9	0.9	1.2
Reaction time false alarm rate	1.2	1.7	4.2	2.0	-1.0	1.7	0.8	-1.0	-0.7
Reaction time premature initiation rate	0.2	0.2	0.7	0.1	-0.3	-0.4	-0.6	0.9	0.2
Reaction time premature initiations	0.4	0.7	1.7	-0.4	0.1	-0.9	-1.1	1.3	-0.1
Std. dev. reaction times	0.3	0.5	1.6	0.5	-0.5	0.7	1.3	-0.6	0.5
Reaction time trials completed	0.6	1.1	1.7	-1.0	0.8	-1.3	-1.3	0.8	-0.8
Reaction time trials AUC	0.5	0.9	1.5	-0.9	0.7	-1.2	-1.2	0.8	-0.7
Run reversals in cocaine runway, females	1.5	1.5	3.6	-1.8	0.2	-0.8	0.1	1.2	1.9
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.2	0.5	-0.3	-0.1	0.4	-0.6
Latency to leave start box in cocaine runway	0.2	0.2	0.7	-0.3	0.8	0.1	-0.3	-0.4	-0.5
Latency to leave start box in cocaine runway, F	1.2	1.3	3.0	-0.5	1.7	-0.2	-1.1	-0.8	-1.7
Latency to leave start box in cocaine runway, M	0.7	0.6	1.6	0.2	-0.6	0.7	1.1	-0.3	1.3
Std. dev. time between licks in bursts	0.4	0.5	1.2	-1.1	0.1	-0.9	0.1	0.4	0.9
Total sessions with >9 infusions	1.6	2.0	5.1	-1.5	0.5	-1.6	-2.3	1.0	-0.9
Short access day 1 total inactive lever presses	0.2	0.3	0.6	0.1	-0.7	-0.0	-0.5	0.8	-0.5
Short access day 10 total inactive lever presses	0.1	0.3	0.9	-0.2	-0.0	-0.2	0.3	0.7	1.0
Short access day 1 total infusions	2.3	3.0	7.8	-1.5	0.7	-1.7	-2.8	0.9	-2.0
Short access day 10 total infusions	0.4	0.5	2.1	0.2	-1.4	-0.1	-0.5	0.9	0.2
Short access total infusions	0.4	0.5	1.5	0.0	-0.4	-0.3	-1.2	0.3	-1.0
Short access day 1 locomotion	2.6	3.2	6.6	-1.8	-0.3	-2.2	-2.6	2.1	-0.5
Short access day 10 total locomotion	1.0	1.8	7.3	1.1	-2.7	0.8	0.6	0.2	1.3
Short access total locomotion	0.8	0.9	1.4	-0.7	-1.2	-0.9	-1.2	1.1	0.3
One hour access (0.3 mA shock)	0.3	0.4	0.8	0.9	-0.8	0.6	0.1	-0.3	-0.4
Compulsive drug intake	0.3	0.4	1.3	0.4	0.4	0.5	0.3	-1.1	-0.7
One hour access (shock baseline)	0.2	0.3	1.0	0.4	-1.0	0.1	-0.0	0.8	0.2
Social response proportion	0.1	0.1	0.2	-0.0	0.4	-0.3	-0.4	-0.1	-0.3
Social responses	0.2	0.2	0.8	0.4	-0.4	0.2	-0.2	-0.9	0.1
Social time	0.3	0.5	0.9	0.5	0.7	0.5	0.7	-0.9	-0.6
Soleus weight	0.2	0.5	2.0	-0.1	0.3	-0.3	-1.4	0.3	-0.8
Bone: stiffness	0.3	0.4	1.6	0.9	-1.3	0.3	0.2	-0.3	0.0
Tibialis anterior weight	0.8	2.6	7.0	-1.3	-0.8	-0.8	-0.5	2.3	2.7
Time to tail flick, vehicle, before self-admin	0.9	1.0	1.8	1.4	-0.0	0.9	0.9	-1.0	-1.2
Time to tail flick, vehicle, after self-admin	0.5	0.6	1.5	-0.1	0.8	-0.8	-0.6	0.7	-1.2
Time to tail flick, test, before self-admin	1.0	1.0	1.3	1.1	-1.1	0.9	1.1	-0.9	0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.5	-0.5	0.1	-0.1	0.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	0.1	-0.6	0.1	0.5	0.8	0.8
Delta time to tail flick, test, before/after SA	0.2	0.2	0.9	0.4	0.3	-0.1	-0.3	0.1	-1.0
Tibia length	0.5	1.3	2.9	-0.4	0.8	-1.2	-1.6	0.1	-1.7
Ambulatory time before self-admin	0.6	0.9	2.2	-0.0	1.5	0.3	-0.3	-0.9	-1.4
Ambulatory time after self-admin	0.2	0.3	0.7	0.4	0.2	0.3	-0.3	-0.7	-0.8
Bone: tissue strength	1.1	1.1	1.7	-0.7	1.3	-1.1	-1.3	-0.3	-1.3
Total heroin consumption	1.7	2.0	5.2	1.1	1.2	0.9	-0.1	-1.8	-2.3
Bone: trabecular number	0.1	0.2	0.6	0.8	-0.6	0.1	0.1	0.3	-0.5
Bone: trabecular spacing	0.1	0.2	0.6	0.0	-0.1	0.3	0.5	-0.8	0.5
Bone: trabecular thickness	0.4	0.5	1.8	-0.0	-0.6	-0.7	-0.4	1.4	0.3
Bone: trabecular tissue density	2.2	3.2	4.7	-2.0	1.3	-2.2	-2.2	1.9	-0.6
Water consumed over 24 hours	0.2	0.2	0.9	-0.5	-0.2	0.1	-0.2	0.2	0.9
Number of responses in last shaping day	0.3	0.4	0.6	-0.8	0.6	-0.6	-0.8	0.3	-0.3