Hub : Genes

Pip5k1c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Pip5k1c 0.17 0.1 7.2e-16 0.14 0.14 0.14 0.13 5.6e-13 8.7e-13 1.7e-12 1.8e-12
2 LHb gene expression Pip5k1c 0.19 0.13 1.2e-03 0.09 0.05 0.06 0.06 4.2e-03 2.5e-02 1.2e-02 1.3e-02
3 BLA mRNA stability Pip5k1c 0.13 0.09 4.6e-07 0.12 0.12 0.12 0.13 3.3e-07 3.9e-07 3.7e-07 1.3e-07
4 NAcc mRNA stability Pip5k1c 0.1 0.08 1.0e-08 0.08 0.07 0.07 0.08 1.3e-09 8.0e-09 7.1e-09 1.1e-09
5 Brain isoform ratio NM_001009967.2 0.05 0.04 8.2e-03 0.02 0.01 0.01 0.01 9.3e-03 7.8e-02 2.1e-02 3.3e-02
6 PL mRNA stability Pip5k1c 0.18 0.13 0.0e+00 0.13 0.17 0.17 0.17 1.5e-14 1.1e-18 2.2e-18 7.8e-19
7 OFC mRNA stability Pip5k1c 0.31 0.16 6.9e-08 0.27 0.29 0.29 0.29 3.5e-07 1.0e-07 1.5e-07 1.0e-07
8 IL mRNA stability Pip5k1c 0.49 0.19 1.2e-09 0.22 0.21 0.21 0.21 6.8e-06 9.7e-06 1.1e-05 1.1e-05
9 Adipose gene expression Pip5k1c 0.04 0.03 2.5e-04 0.03 0.03 0.03 0.03 2.3e-04 3.6e-04 6.1e-04 4.4e-04
10 Brain gene expression Pip5k1c 0.34 0.2 6.6e-10 0.12 0.12 0.11 0.11 6.2e-11 8.6e-11 9.3e-11 9.6e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.81.47.01.2-1.2-1.2-1.0-1.1-0.40.1-0.50.62.6
Area under the delay curve1.71.82.7-1.31.21.21.21.41.51.5-1.61.60.4
BMI with tail6.119.723.6-4.64.54.64.84.94.84.7-4.64.6-0.7
BMI without tail2.55.17.6-2.42.42.42.72.82.42.2-2.02.0-1.0
Body weight1.14.85.5-2.32.42.32.32.32.32.3-2.22.2-0.6
Weight adjusted by age0.50.51.1-0.70.80.91.00.90.70.5-0.40.4-0.7
Bone surface2.34.015.12.2-2.2-2.2-2.1-2.1-1.0-0.4-0.30.33.9
Bone volume2.44.015.12.2-2.2-2.2-2.1-2.1-1.0-0.4-0.20.33.9
Breakpoint value in progressive ratio session4.24.66.92.1-2.0-2.0-2.2-2.1-2.4-2.42.5-2.6-0.4
Number of licking bursts0.40.51.9-0.80.80.80.60.60.40.3-0.0-0.2-1.4
Context. condit. distance diff. score0.30.40.5-0.60.70.70.60.60.70.7-0.70.5-0.2
Locomotion velocity, session 11.11.22.01.3-1.3-1.3-1.2-1.2-1.0-0.80.6-0.51.4
Locomotion distance, session 10.70.83.40.9-1.0-1.0-0.9-0.9-0.5-0.3-0.00.11.8
Locomotion velocity, session 24.55.37.12.6-2.7-2.7-2.5-2.5-2.3-2.01.7-1.62.1
Locomotion distance, session 22.33.34.62.0-2.1-2.1-2.0-2.0-1.6-1.41.0-1.02.1
Locomotion velocity, session 35.46.37.82.6-2.5-2.6-2.5-2.5-2.8-2.82.8-2.70.2
Locomotion distance, session 30.00.00.10.0-0.0-0.00.10.1-0.1-0.20.2-0.1-0.2
Stereotopy head waving bouts, day 34.65.46.42.5-2.5-2.5-2.5-2.5-2.5-2.42.2-2.21.0
Stereotopy head waving duration, day 35.26.27.22.6-2.6-2.6-2.6-2.6-2.7-2.62.5-2.50.8
Locomotion velocity, session 70.90.91.21.0-1.1-1.1-1.1-1.1-1.0-0.90.9-0.80.6
Locomotion distance, session 70.20.20.8-0.50.50.50.60.60.30.1-0.00.1-0.9
Stereotopy head waving bouts, day 70.30.42.00.6-0.5-0.5-0.6-0.5-0.20.1-0.30.31.4
Stereotopy head waving duration, day 70.70.82.71.0-0.9-0.9-1.1-1.0-0.5-0.30.0-0.11.7
Locomotion velocity, session 81.21.54.11.4-1.4-1.4-1.4-1.4-0.9-0.50.2-0.32.0
Locomotion distance, session 80.20.20.50.5-0.6-0.6-0.6-0.5-0.4-0.30.2-0.20.7
Degree of sensitization distance0.30.30.5-0.60.60.60.60.50.70.7-0.70.6-0.0
Degree of sensitization stereotypy1.31.42.7-0.90.90.90.80.91.31.5-1.61.61.0
Conditioned locomotion2.42.84.0-2.02.02.02.01.81.61.3-1.11.1-1.6
Cocaine response after cond. corrected6.06.78.8-2.92.92.93.02.92.62.4-2.12.0-1.8
Cocaine response after cond. not corrected6.67.310.0-3.13.13.13.23.02.72.4-2.12.1-1.9
Cocaine response before conditioning0.60.70.91.0-0.9-1.0-0.8-0.9-0.9-0.80.7-0.60.6
Saline control response0.10.10.2-0.50.40.40.50.40.30.2-0.10.2-0.5
Bone: connectivity density0.40.73.90.5-0.6-0.5-0.3-0.40.10.5-0.81.02.0
Bone: cortical apparent density1.01.32.0-1.11.31.31.01.01.31.4-1.41.0-0.2
Bone: cortical area0.40.72.0-0.10.20.20.10.10.71.0-1.31.11.4
Bone: cortical porosity0.70.81.21.0-1.0-1.0-1.1-1.1-0.8-0.70.6-0.60.8
Bone: cortical porosity0.30.41.30.6-0.6-0.6-0.7-0.7-0.2-0.1-0.10.11.2
Bone: cortical thickness0.91.42.7-1.01.01.00.90.91.41.5-1.61.50.6
Bone: cortical thickness0.10.10.7-0.30.30.30.30.40.1-0.10.3-0.3-0.8
Bone: cortical tissue density0.71.01.5-0.91.11.10.90.81.11.2-1.20.8-0.2
Condit. Reinf. active minus inactive responses3.74.25.02.1-2.2-2.2-2.1-2.1-2.2-2.22.2-2.20.4
Condit. Reinf. active-inactive response ratio1.71.82.81.2-1.2-1.2-1.2-1.2-1.5-1.61.7-1.7-0.5
Condit. Reinf. active responses3.84.65.82.4-2.4-2.4-2.4-2.3-2.2-2.11.9-1.91.3
Condit. Reinf. inactive responses1.31.52.31.4-1.5-1.4-1.4-1.4-1.1-0.90.7-0.71.5
Incentive salience index mean2.42.93.71.9-1.9-1.9-1.9-1.8-1.7-1.61.4-1.51.1
Condit. Reinf. lever presses0.60.84.10.9-0.9-0.9-0.9-0.8-0.4-0.0-0.30.22.0
Condit. Reinf. active minus inactive responses1.82.23.81.2-1.2-1.2-1.3-1.3-1.7-1.81.9-1.9-0.8
Condit. Reinf. active-inactive response ratio0.40.42.6-0.40.40.40.30.4-0.1-0.40.7-0.7-1.6
Condit. Reinf. active responses2.12.93.71.7-1.7-1.7-1.7-1.7-1.9-1.91.9-1.90.0
Condit. Reinf. inactive responses1.51.82.51.5-1.6-1.6-1.5-1.5-1.4-1.31.1-1.10.9
Condit. Reinf. lever presses1.92.54.01.4-1.4-1.5-1.4-1.4-1.8-1.92.0-2.0-0.6
Condit. Reinf. lever reinforcers received1.52.13.21.3-1.4-1.4-1.4-1.3-1.6-1.71.8-1.7-0.3
Conditioned reinforcement - actives2.62.63.21.8-1.7-1.7-1.6-1.7-1.6-1.71.6-1.70.5
Conditioned reinforcement - inactives1.01.11.9-1.31.41.41.00.90.90.8-0.60.6-1.3
Conditioned locomotion7.38.811.03.0-3.0-3.0-3.0-3.0-3.3-3.33.2-3.20.3
Patch foraging indifference point 0 sec0.10.20.3-0.50.50.40.30.20.50.6-0.60.50.1
Patch foraging indifference point AUC0.91.01.41.1-1.1-1.0-0.8-0.8-1.1-1.21.2-1.20.0
Delay disc. indifference point, 0s delay5.25.79.7-2.02.02.01.91.92.62.9-3.13.11.6
Delay disc. indifference point, 16s delay0.10.10.2-0.30.30.30.30.40.40.4-0.40.40.2
Delay disc. indifference point, 2s delay4.44.97.4-2.12.02.02.02.02.52.6-2.72.70.8
Delay disc. indifference point, 24s delay0.50.51.0-0.70.60.60.91.00.70.7-0.70.80.1
Delay disc. indifference point, 4s delay0.80.81.7-0.60.50.50.60.70.91.1-1.21.31.1
Delay disc. indifference point, 8s delay1.21.21.6-1.21.21.21.21.31.11.0-0.91.0-0.7
Indifference point function ln k0.20.30.5-0.70.70.70.50.40.60.7-0.60.5-0.3
Indifference point function log k0.20.30.5-0.70.70.70.50.40.60.7-0.60.5-0.3
Patch foraging total patch changes 0 sec0.10.20.3-0.50.50.50.30.20.50.5-0.50.4-0.1
Patch foraging total patch changes 12 sec0.50.71.2-1.00.90.91.01.10.80.5-0.40.4-0.9
Patch foraging total patch changes 18 sec0.91.11.51.1-1.0-1.1-1.1-1.1-1.1-1.11.1-1.20.1
Patch foraging total patch changes 24 sec0.10.10.30.4-0.5-0.5-0.2-0.2-0.3-0.40.3-0.30.3
Patch foraging total patch changes 6 sec0.10.20.40.3-0.4-0.4-0.6-0.6-0.5-0.40.4-0.6-0.1
Patch foraging time to switch 0 sec1.11.73.5-1.11.01.00.80.91.51.6-1.71.91.0
Patch foraging water rate 0 sec0.20.42.1-0.50.50.50.50.4-0.1-0.20.5-0.7-1.5
Patch foraging water rate 12 sec1.52.33.5-1.71.81.81.91.81.31.1-0.90.7-1.6
Patch foraging water rate 18 sec0.91.26.5-0.80.80.80.90.8-0.0-0.40.8-1.0-2.5
Patch foraging water rate 24 sec1.92.79.8-1.91.91.81.71.60.80.40.1-0.2-3.1
Patch foraging water rate 6 sec0.50.73.3-0.10.00.00.10.1-0.6-0.91.2-1.1-1.8
Seeking ratio, delayed vs. immediate footshock5.15.97.22.6-2.7-2.7-2.6-2.5-2.6-2.52.3-2.20.9
Distance traveled before self-admin0.20.20.3-0.30.30.30.30.40.40.5-0.60.50.4
Distance traveled after self-admin1.01.11.41.1-1.2-1.2-1.2-1.0-1.2-1.11.0-1.00.4
Extensor digitorum longus weight4.618.222.5-4.74.64.64.64.74.54.2-3.93.9-2.0
Bone: elastic displacement0.30.30.40.6-0.6-0.6-0.7-0.7-0.6-0.60.5-0.50.2
Bone: elastic work0.10.20.4-0.10.20.20.00.00.40.5-0.60.60.6
Bone: endosteal estimation0.10.30.8-0.20.30.30.20.30.60.7-0.90.80.8
Bone: endosteal perimeter0.51.02.01.2-1.2-1.1-1.2-1.2-0.8-0.50.3-0.41.4
Epididymis fat weight0.10.30.60.3-0.3-0.3-0.2-0.2-0.4-0.70.8-0.8-0.7
Delta time in closed arm before/after self-admin1.91.84.4-1.51.41.51.81.61.00.5-0.20.3-2.1
Delta time in open arm before/after self-admin1.11.01.6-1.01.11.10.80.91.11.2-1.31.20.1
Diff in mean of infusions in LGA sessions1.41.51.91.3-1.2-1.2-1.2-1.3-1.4-1.41.3-1.40.0
Delay discount exponential model param1.51.62.41.2-1.2-1.2-1.2-1.4-1.4-1.41.5-1.5-0.4
Extinction: sum of active levers before priming0.90.91.90.6-0.5-0.5-0.6-0.7-0.9-1.11.3-1.4-1.2
Active lever presses in extinction session 63.13.03.71.9-1.8-1.8-1.9-1.9-1.8-1.81.7-1.80.4
Bone: final force0.81.32.7-0.70.70.70.70.81.21.4-1.71.61.2
Bone: final moment0.61.02.3-0.60.60.60.50.61.11.3-1.51.41.1
Food consumed during 24 hour testing period0.50.50.6-0.80.80.80.80.80.80.8-0.80.7-0.2
Glucose1.11.72.2-1.41.41.41.41.51.41.3-1.21.3-0.4
Heart weight0.30.40.90.4-0.4-0.4-0.2-0.2-0.7-0.80.9-0.8-0.7
Delay discount hyperbolic model param2.22.33.41.5-1.4-1.4-1.5-1.5-1.7-1.71.8-1.9-0.4
Intermittent access intake day 1-15 change5.75.78.02.3-2.2-2.2-2.5-2.4-2.6-2.72.8-2.8-0.3
Intermittent access intake escalation4.94.88.61.8-1.7-1.7-2.0-2.0-2.4-2.62.9-2.9-1.3
Intermittent access intake escalation 26.16.010.22.1-2.1-2.1-2.2-2.2-2.7-3.03.2-3.2-1.1
Intermitt. access day 1 inactive lever presses0.30.40.90.2-0.3-0.3-0.3-0.2-0.7-0.80.9-0.9-0.9
Intermitt. access day 15 inactive lever presses0.30.30.60.3-0.2-0.2-0.5-0.5-0.7-0.60.7-0.8-0.6
Intermitt. access escalation Index0.40.42.00.3-0.2-0.2-0.1-0.10.30.5-0.80.71.4
Intermittent access day 1 total infusions0.10.10.2-0.10.30.30.10.00.30.4-0.40.30.1
Intermittent access day 15 total infusions1.31.52.81.1-0.9-0.9-1.2-1.3-1.3-1.41.5-1.7-0.7
Intermittent access terminal intake (last 3 days)1.01.01.51.2-1.0-1.0-1.0-1.1-1.1-1.11.0-1.20.1
Intermittent access total infusions0.10.10.30.3-0.1-0.1-0.4-0.5-0.3-0.30.4-0.6-0.4
Intermittent access day 1 locomotion0.20.20.40.4-0.2-0.2-0.5-0.6-0.5-0.40.5-0.6-0.4
Intermittent access day 15 total locomotion2.83.04.61.7-1.5-1.5-1.8-1.8-2.0-1.92.0-2.2-0.5
Intermittent access total locomotion0.91.01.41.1-0.9-0.9-1.2-1.2-1.2-1.01.0-1.2-0.1
Intermittent access standard deviation2.62.74.31.6-1.5-1.5-1.5-1.5-1.8-1.92.0-2.1-0.4
Left kidney weight0.20.51.80.8-0.8-0.8-0.6-0.6-0.3-0.20.0-0.01.4
Right kidney weight1.54.25.22.2-2.3-2.3-2.1-2.2-2.1-2.12.0-2.00.8
Cocaine induced anxiety1.21.42.21.4-1.5-1.5-1.2-1.2-1.1-1.00.7-0.61.4
Post-drug Anxiety1.21.33.71.4-1.5-1.5-1.0-1.0-0.9-0.70.4-0.31.9
Baseline Anxiety0.10.10.3-0.20.20.20.10.1-0.1-0.10.2-0.3-0.6
Tail length2.67.810.82.7-2.6-2.6-2.8-2.8-3.1-3.23.3-3.3-0.5
Length with tail1.86.58.82.6-2.5-2.6-2.9-3.0-2.8-2.62.6-2.60.4
Length without tail0.20.51.20.6-0.7-0.7-0.9-1.0-0.5-0.2-0.00.01.1
Times rat made contact with spout0.40.40.8-0.80.70.70.80.80.50.4-0.20.3-0.9
Lifetime Intake0.00.00.10.3-0.1-0.1-0.3-0.4-0.1-0.10.1-0.3-0.0
Liver weight, left2.64.15.6-2.22.12.12.32.42.22.0-1.91.9-0.8
Liver weight, right1.52.53.2-1.51.61.61.61.71.71.7-1.71.8-0.1
Locomotor activity3.86.18.72.7-2.7-2.7-3.0-2.9-2.6-2.32.0-2.11.4
Locomotor testing distance2.13.55.02.1-2.0-2.0-2.2-2.2-1.9-1.71.6-1.70.9
Locomotor testing rearing0.00.00.10.10.10.00.00.1-0.1-0.10.2-0.3-0.3
Locomotion in novel chamber0.30.40.80.5-0.7-0.6-0.3-0.2-0.7-0.90.9-0.8-0.1
Locomotion in novel chamber post-restriction0.70.81.11.0-1.0-0.8-0.9-0.9-1.0-1.01.0-1.00.3
Fecal boli incidents, locomotor time 12.32.53.6-1.71.91.91.71.71.61.5-1.31.2-1.2
Change in fecal boli incidents, locomotor task0.90.92.21.1-1.1-1.1-1.0-1.1-0.7-0.50.3-0.31.5
Time >=10cm from walls, locomotor time 10.30.31.1-0.20.10.10.00.10.40.6-0.70.61.0
Bouts of movement, locomotor time 10.10.10.30.4-0.3-0.3-0.4-0.3-0.4-0.30.4-0.5-0.2
Total resting periods, locomotor time 10.20.20.30.6-0.4-0.4-0.5-0.5-0.5-0.40.4-0.60.1
Rest time, locomotor task time 10.20.30.50.6-0.5-0.5-0.7-0.6-0.5-0.40.3-0.50.5
Distance moved, locomotor task time 10.30.31.1-0.20.10.10.20.10.50.6-0.80.91.0
Vertical activity count, locomotor time 10.10.10.2-0.40.30.30.30.30.20.2-0.10.2-0.4
Time >=10cm from walls, locomotor time 21.21.21.7-1.31.31.31.11.31.21.1-1.00.8-0.7
Bouts of movement, locomotor time 20.70.81.41.0-1.0-1.0-1.0-1.0-0.8-0.60.4-0.41.2
Total resting periods, locomotor time 20.80.81.81.0-1.1-1.1-1.0-0.9-0.7-0.60.4-0.41.3
Rest time, locomotor task time 20.70.81.21.1-1.0-1.0-1.0-1.0-0.9-0.70.5-0.71.0
Distance moved, locomotor task time 21.01.11.6-1.31.21.21.11.11.00.9-0.80.8-1.0
Vertical activity count, locomotor time 21.21.42.2-1.41.41.41.21.21.00.9-0.70.5-1.5
Light reinforcement 15.29.611.83.1-3.2-3.3-3.3-3.3-3.4-3.33.2-3.10.5
Light reinforcement 21.62.23.31.5-1.4-1.4-1.7-1.8-1.6-1.51.4-1.50.2
Bone: marrow area0.20.30.8-0.20.30.30.20.30.60.8-0.90.80.7
Bone: maximum diameter1.12.03.31.7-1.6-1.6-1.8-1.7-1.2-0.90.6-0.81.8
Bone: maximum force0.91.53.1-0.90.91.00.80.91.41.6-1.81.60.9
Bone: maximum moment0.71.22.7-0.80.80.90.70.81.31.5-1.61.50.9
Mean time between licks in bursts3.24.56.52.1-2.0-2.0-2.1-2.1-2.4-2.42.5-2.6-0.5
Mean num. licks in bursts0.00.10.30.1-0.2-0.2-0.0-0.00.0-0.0-0.10.30.5
Cd content in liver0.10.10.2-0.30.30.40.30.30.40.4-0.50.50.1
Co content in liver0.50.51.00.5-0.7-0.6-0.7-0.6-0.8-0.91.0-0.9-0.5
Cu content in liver0.20.21.30.2-0.2-0.2-0.3-0.20.10.3-0.50.51.1
Fe content in liver0.10.10.4-0.20.20.20.20.10.0-0.10.2-0.2-0.6
K content in liver0.30.31.60.5-0.7-0.6-0.5-0.4-0.2-0.0-0.20.21.3
Mg content in liver0.50.52.40.7-0.8-0.7-0.6-0.5-0.2-0.0-0.20.21.6
Mn content in liver2.73.07.02.0-2.0-2.0-2.0-2.0-1.3-0.90.5-0.52.6
Na content in liver0.70.71.4-0.70.60.60.50.51.01.1-1.21.20.7
Rb content in liver0.40.52.20.1-0.0-0.1-0.00.00.50.7-1.00.91.5
Se content in liver0.20.30.40.5-0.7-0.6-0.5-0.5-0.5-0.50.5-0.40.3
Sr content in liver0.30.31.8-0.50.40.50.40.40.1-0.10.3-0.3-1.3
Zn content in liver1.51.63.60.7-0.8-0.8-0.6-0.5-1.3-1.71.9-1.9-1.6
Bone: minimum diameter0.10.21.30.4-0.4-0.3-0.4-0.4-0.00.2-0.40.31.1
Time in familiar zone, hab. session 11.71.62.51.2-1.2-1.2-1.1-1.2-1.4-1.51.6-1.5-0.3
Time in novel zone, hab. session 10.70.71.5-0.50.50.50.40.40.91.1-1.21.11.2
Total zone transitions, hab. session 11.41.92.71.6-1.6-1.6-1.6-1.6-1.3-1.10.8-0.81.6
Total locomotion distance, hab. session 12.23.16.42.0-2.1-2.1-2.0-2.0-1.5-1.10.8-0.62.5
Locomotion velocity, hab. session 12.33.34.62.1-2.1-2.1-2.0-2.0-1.7-1.41.1-1.02.1
Time in familiar zone, hab. session 24.95.18.02.1-2.1-2.1-2.0-2.0-2.5-2.72.8-2.7-0.8
Time in novel zone, hab. session 23.43.45.9-1.61.61.61.51.62.12.3-2.42.41.0
Total zone transitions, hab. session 20.40.53.30.2-0.4-0.4-0.3-0.30.20.4-0.70.81.8
Total locomotion distance, hab. session 21.31.72.51.4-1.6-1.6-1.4-1.4-1.2-1.10.9-0.71.4
Locomotion velocity, hab. session 21.41.93.21.5-1.7-1.7-1.5-1.5-1.2-1.00.7-0.61.8
Novel to familiar place preference ratio2.82.95.2-1.31.31.31.31.41.82.1-2.32.31.3
Novelty place preference1.61.63.1-0.90.90.90.91.01.31.6-1.81.81.3
Time in novel zone, NPP test1.91.93.5-1.01.01.01.11.11.51.7-1.91.91.2
Total zone transitions, NPP test0.10.10.90.2-0.3-0.3-0.2-0.3-0.00.1-0.20.30.9
Total locomotion distance, NPP test0.20.31.90.3-0.5-0.5-0.3-0.3-0.00.1-0.30.51.4
Locomotion velocity, NPP test0.30.41.80.6-0.7-0.7-0.6-0.6-0.3-0.2-0.00.21.3
Intraocular pressure0.30.42.0-0.40.40.30.70.80.1-0.30.5-0.4-1.4
Delta distance traveled before/after self-admin1.51.62.11.3-1.3-1.3-1.3-1.3-1.4-1.41.3-1.30.1
Delta ambulatory time before/after self-admin1.82.02.61.6-1.6-1.6-1.5-1.5-1.5-1.41.3-1.30.7
Parametrial fat weight0.30.61.00.7-0.6-0.6-0.8-0.8-1.0-0.91.0-1.0-0.4
Pavlov. Cond. lever latency0.20.31.8-0.50.50.50.40.40.1-0.10.3-0.4-1.3
Pavlov. Cond. magazine entry latency2.22.93.91.7-1.7-1.7-1.7-1.7-1.9-1.91.9-2.0-0.1
Pavlov. Cond. change in total contacts0.10.10.10.3-0.3-0.3-0.3-0.3-0.3-0.30.3-0.20.2
Pavlov. Cond. index score0.50.70.90.9-1.0-1.0-0.9-0.9-0.8-0.60.5-0.50.9
Pavlov. Cond. latency score0.70.91.71.1-1.1-1.1-1.1-1.1-0.8-0.60.4-0.41.3
Pavlov. Cond. lever contacts0.50.62.60.8-0.8-0.8-0.7-0.7-0.4-0.2-0.10.21.6
Pavlov. Cond. magazine entry number0.50.60.8-0.80.80.80.80.80.90.9-0.80.9-0.1
Pavlov. Cond. intertrial magazine entries0.10.20.9-0.20.10.10.10.1-0.1-0.30.5-0.6-1.0
Pavlov. Cond. lever-magazine prob. diff.0.91.11.41.2-1.2-1.2-1.2-1.1-1.0-0.90.8-0.80.9
Pavlov. Cond. response bias0.91.11.31.1-1.1-1.1-1.1-1.1-1.2-1.11.1-1.10.3
Pavlov. Cond. lever latency0.91.21.5-1.21.21.21.21.21.21.2-1.11.0-0.3
Pavlov. Cond. magazine entry latency0.60.71.11.0-0.9-0.9-1.0-0.8-0.9-0.70.6-0.70.6
Pavlov. Cond. change in total contacts0.81.11.51.1-1.1-1.1-1.1-1.0-1.2-1.21.2-1.1-0.0
Pavlov. Cond. index score0.91.21.51.2-1.1-1.2-1.2-1.1-1.2-1.11.1-1.10.2
Pavlov. Cond. latency score0.91.21.51.2-1.1-1.2-1.2-1.2-1.1-1.01.0-1.00.5
Pavlov. Cond. lever contacts0.71.01.31.0-1.0-1.0-0.9-0.9-1.1-1.11.2-1.1-0.1
Pavlov. Cond. magazine entry number1.01.21.7-1.31.21.21.31.11.21.0-0.91.0-0.6
Pavlov. Cond. intertrial magazine entries0.60.81.4-1.21.11.10.90.90.90.7-0.60.4-0.9
Pavlov. Cond. lever-magazine prob. diff.1.01.31.61.3-1.2-1.2-1.3-1.2-1.2-1.11.1-1.10.4
Pavlov. Cond. response bias1.72.33.01.5-1.5-1.5-1.5-1.4-1.7-1.71.7-1.7-0.1
Time in closed arm before self-admin0.50.61.6-0.50.50.40.30.30.71.0-1.21.30.9
Time in closed arm after self-admin0.00.00.1-0.0-0.2-0.20.20.0-0.2-0.30.3-0.1-0.1
Time in open arm before self-admin0.91.01.60.9-1.0-1.0-0.9-0.8-1.1-1.21.3-1.2-0.2
Time in open arm after self-admin0.80.91.3-1.01.11.10.80.91.01.0-0.90.8-0.5
Bone: periosteal estimation0.30.72.5-0.00.10.1-0.10.00.61.0-1.31.11.6
Bone: periosteal perimeter0.50.72.91.0-0.9-0.9-1.0-1.0-0.4-0.1-0.20.01.7
Bone: post-yield work0.60.81.1-0.91.01.00.80.91.01.1-1.00.8-0.1
Progressive ratio test 1 active lever presses0.20.20.4-0.50.70.70.50.40.50.4-0.30.2-0.5
Progressive ratio test 1 breakpoint0.30.30.4-0.50.70.70.60.50.50.5-0.50.3-0.4
Progressive ratio test 1 inactive lever presses0.00.00.00.1-0.0-0.0-0.1-0.2-0.1-0.00.0-0.1-0.0
Progressive ratio test 2 active lever presses0.20.20.50.3-0.2-0.2-0.2-0.2-0.4-0.50.6-0.7-0.5
Progressive ratio test 2 breakpoint0.30.30.50.7-0.6-0.6-0.5-0.5-0.5-0.60.6-0.70.1
Progressive ratio test 2 inactive lever presses0.10.10.20.4-0.2-0.2-0.3-0.4-0.3-0.20.1-0.20.2
Incentive Sensitization - Responses0.30.30.60.5-0.4-0.4-0.2-0.2-0.5-0.70.7-0.8-0.4
Incentive Sensitization - Breakpoint0.30.30.60.6-0.6-0.6-0.3-0.3-0.5-0.70.8-0.8-0.1
Sum of active levers in priming session hrs 5-60.00.00.1-0.10.20.2-0.1-0.00.10.1-0.0-0.1-0.3
Progressive ratio0.30.30.8-0.50.50.50.90.90.50.4-0.30.4-0.5
Food seeking constrained by brief footshock0.10.10.30.3-0.5-0.5-0.2-0.2-0.4-0.50.5-0.30.0
Seeking ratio, punishment vs. effort0.20.20.50.3-0.4-0.3-0.7-0.7-0.5-0.30.3-0.30.2
Retroperitoneal fat weight0.61.83.0-1.61.71.71.21.21.31.4-1.21.0-1.1
Reaction time number correct0.91.32.1-1.41.31.31.51.31.00.8-0.60.5-1.3
Reaction time mean minus median0.70.91.51.2-1.1-1.1-0.9-0.9-1.0-0.90.8-1.10.5
Reaction time mean minus median AUC0.50.63.00.9-0.7-0.7-0.6-0.6-0.20.1-0.40.21.7
Reaction time num false alarms0.10.10.2-0.30.30.30.40.40.30.1-0.00.0-0.4
Reaction time num false alarms AUC0.20.30.7-0.60.60.60.70.70.50.3-0.10.1-0.8
Reaction time trials correct on left0.91.32.1-1.41.31.31.51.31.00.8-0.60.5-1.3
Reaction time trials on left0.91.32.0-1.31.31.31.41.21.00.8-0.60.5-1.2
Reaction time mean0.20.31.70.6-0.4-0.4-0.3-0.3-0.00.2-0.40.21.3
Reaction time mean AUC0.20.31.60.5-0.3-0.3-0.3-0.20.10.3-0.50.31.2
Median of all reaction times0.30.41.50.00.10.10.10.20.50.7-0.90.71.2
Reaction time omissions0.30.40.60.7-0.6-0.6-0.7-0.7-0.5-0.40.4-0.60.5
Reaction time false alarm rate0.00.00.00.1-0.1-0.1-0.00.00.10.0-0.10.10.2
Reaction time premature initiation rate0.81.02.10.5-0.6-0.6-0.9-0.9-1.2-1.21.3-1.4-1.0
Reaction time premature initiations0.50.73.2-0.10.10.0-0.2-0.2-0.7-0.81.1-1.3-1.8
Std. dev. reaction times0.40.51.01.0-0.8-0.8-0.6-0.7-0.5-0.40.2-0.51.0
Reaction time trials completed0.91.32.0-1.31.31.31.41.21.00.8-0.60.5-1.2
Reaction time trials AUC0.91.42.2-1.41.41.31.51.31.00.7-0.50.4-1.5
Run reversals in cocaine runway, females1.01.02.01.1-1.3-1.4-0.8-0.8-0.9-0.90.8-0.50.9
Run reversals in cocaine runway, males1.61.62.41.4-1.6-1.5-1.2-1.3-1.2-1.21.1-1.00.9
Latency to leave start box in cocaine runway1.71.83.01.6-1.4-1.4-1.7-1.7-1.2-0.80.6-0.91.6
Latency to leave start box in cocaine runway, F0.90.94.81.0-0.9-0.8-1.0-1.0-0.30.1-0.50.22.2
Latency to leave start box in cocaine runway, M2.01.93.81.2-1.0-1.2-1.2-1.2-1.5-1.61.8-1.9-1.0
Std. dev. time between licks in bursts1.21.42.01.3-1.3-1.3-1.4-1.4-1.1-0.90.7-0.81.2
Total sessions with >9 infusions0.20.21.20.6-0.5-0.5-0.3-0.4-0.10.0-0.20.11.1
Short access day 1 total inactive lever presses0.00.00.10.2-0.1-0.1-0.1-0.2-0.1-0.20.2-0.2-0.0
Short access day 10 total inactive lever presses0.10.10.7-0.20.20.20.00.1-0.2-0.30.4-0.4-0.8
Short access day 1 total infusions0.40.41.30.9-0.7-0.7-0.6-0.8-0.3-0.2-0.0-0.11.1
Short access day 10 total infusions0.00.00.10.20.00.00.0-0.10.10.0-0.1-0.20.1
Short access total infusions0.10.10.60.5-0.3-0.3-0.1-0.2-0.00.1-0.20.00.8
Short access day 1 locomotion1.01.02.21.1-0.9-0.9-1.4-1.5-1.1-0.80.7-0.90.5
Short access day 10 total locomotion3.43.85.71.8-1.7-1.7-2.0-2.0-2.2-2.22.3-2.4-0.5
Short access total locomotion1.01.01.51.2-1.0-1.0-1.1-1.2-1.1-0.90.8-1.00.3
One hour access (0.3 mA shock)0.20.30.4-0.50.70.70.40.30.60.6-0.50.4-0.3
Compulsive drug intake0.70.71.4-0.90.70.70.70.70.90.9-0.91.20.2
One hour access (shock baseline)0.10.10.6-0.10.30.3-0.0-0.10.0-0.10.2-0.4-0.7
Social response proportion0.70.81.21.1-1.1-1.1-0.9-0.9-0.9-0.90.8-0.60.6
Social responses8.110.413.43.6-3.7-3.7-3.3-3.3-3.4-3.33.0-2.81.5
Social time0.81.01.3-1.11.11.11.11.11.01.0-0.90.9-0.5
Soleus weight8.023.528.5-4.95.04.95.14.95.35.3-5.35.2-0.7
Bone: stiffness2.33.76.0-1.81.71.81.71.72.22.3-2.42.30.5
Tibialis anterior weight0.82.83.9-1.71.61.61.72.01.81.8-1.81.9-0.1
Time to tail flick, vehicle, before self-admin1.21.32.41.4-1.4-1.4-1.1-1.1-0.9-0.80.5-0.41.6
Time to tail flick, vehicle, after self-admin0.20.20.9-0.20.10.00.40.4-0.2-0.40.6-0.4-1.0
Time to tail flick, test, before self-admin0.70.72.81.0-1.0-1.0-0.6-0.8-0.5-0.30.1-0.01.7
Time to tail flick, test, after self-admin0.40.40.90.9-0.8-0.8-0.4-0.6-0.5-0.40.2-0.30.9
Delta time to tail flick, vehicle, before/after SA1.31.32.9-1.41.31.31.31.30.80.6-0.30.4-1.7
Delta time to tail flick, test, before/after SA0.20.21.1-0.10.10.10.10.1-0.2-0.30.5-0.5-1.0
Tibia length0.72.12.81.4-1.3-1.3-1.5-1.5-1.6-1.61.7-1.7-0.2
Ambulatory time before self-admin0.10.10.2-0.30.40.40.30.40.50.5-0.50.40.2
Ambulatory time after self-admin0.60.60.90.8-0.8-0.8-1.0-0.7-0.9-0.80.7-0.80.3
Bone: tissue strength1.61.52.5-1.11.21.21.01.11.41.5-1.61.40.2
Total heroin consumption1.92.22.91.7-1.6-1.6-1.7-1.6-1.5-1.51.4-1.50.5
Bone: trabecular number1.42.33.61.8-1.9-1.8-1.6-1.6-1.4-1.10.8-0.61.9
Bone: trabecular spacing1.82.36.8-1.71.71.71.61.71.00.6-0.10.1-2.6
Bone: trabecular thickness2.12.611.91.6-1.6-1.6-1.5-1.6-0.50.0-0.60.73.5
Bone: trabecular tissue density2.73.85.6-2.22.42.31.91.92.12.0-1.81.4-1.4
Water consumed over 24 hours0.40.51.1-0.30.30.30.30.30.60.8-1.01.01.1
Number of responses in last shaping day0.20.20.40.5-0.4-0.4-0.5-0.7-0.5-0.30.3-0.40.2