Hub : Genes

Pim3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Pim3	0.01	0.01	9.5e-03	0.01	0.01	0.01	0.01	2.3e-03	3.6e-03	3.3e-03	3.6e-03
2	Liver	gene expression	Pim3	0.04	0.03	6.5e-04	0.02	0.01	0.01	0.01	2.2e-03	2.3e-02	4.2e-02	9.9e-03
3	pVTA	mRNA stability	Pim3	0.03	0.03	5.4e-03	0.04	0.02	0.02	0.03	8.0e-04	5.3e-03	1.5e-02	4.2e-03
4	Adipose	gene expression	Pim3	0.13	0.09	5.1e-07	0.06	0.05	0.04	0.06	1.9e-07	2.0e-06	1.2e-05	2.3e-07
5	Adipose	mRNA stability	Pim3	0.02	0.02	2.0e-03	0.02	0.01	0.01	0.01	5.7e-03	8.7e-03	2.1e-02	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	1.1	1.9	2.8	-1.4	-1.7	1.6	1.0	-1.0
Area under the delay curve	0.9	1.1	1.2	-1.1	-1.1	0.9	1.1	-1.1
BMI with tail	4.5	15.7	17.7	4.2	4.1	-3.8	-3.8	3.9
BMI without tail	2.5	7.6	8.0	2.8	2.8	-2.7	-2.7	2.7
Body weight	1.9	8.3	9.3	3.1	3.0	-2.6	-2.8	2.8
Weight adjusted by age	1.9	2.9	3.2	1.7	1.7	-1.8	-1.7	1.7
Bone surface	0.9	1.6	2.3	-1.4	-1.2	1.5	1.1	-1.0
Bone volume	1.3	2.3	2.9	-1.6	-1.7	1.7	1.3	-1.3
Breakpoint value in progressive ratio session	0.0	0.1	0.1	0.4	0.0	-0.1	-0.3	0.3
Number of licking bursts	0.0	0.1	0.3	-0.1	-0.5	0.1	-0.0	0.0
Context. condit. distance diff. score	2.2	2.7	3.5	1.9	1.7	-1.5	-1.6	1.5
Locomotion velocity, session 1	0.1	0.1	0.3	0.2	-0.2	-0.4	-0.5	0.5
Locomotion distance, session 1	2.7	3.4	3.8	-2.0	-1.8	1.9	1.7	-1.8
Locomotion velocity, session 2	0.8	0.9	1.3	1.0	0.6	-0.8	-1.2	1.1
Locomotion distance, session 2	1.2	1.6	2.0	-1.4	-1.3	1.3	1.2	-1.3
Locomotion velocity, session 3	0.3	0.3	0.6	0.3	0.4	-0.3	-0.8	0.7
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	0.3	0.2	0.1	-0.2
Stereotopy head waving bouts, day 3	1.8	2.1	2.7	-1.6	-1.1	1.5	1.6	-1.5
Stereotopy head waving duration, day 3	0.6	0.8	0.9	-0.9	-0.8	0.8	0.9	-0.9
Locomotion velocity, session 7	0.9	0.9	1.8	0.9	0.9	-1.3	-0.8	0.8
Locomotion distance, session 7	0.2	0.2	0.6	0.4	-0.2	-0.8	-0.4	0.3
Stereotopy head waving bouts, day 7	0.8	0.9	1.8	-0.9	-0.9	1.3	0.7	-0.8
Stereotopy head waving duration, day 7	0.6	0.8	1.4	-1.0	-0.7	1.2	0.7	-0.7
Locomotion velocity, session 8	1.4	1.7	2.4	1.3	0.7	-1.3	-1.5	1.5
Locomotion distance, session 8	0.6	0.9	1.1	1.0	1.0	-0.7	-1.0	0.9
Degree of sensitization distance	1.0	1.1	1.6	1.0	0.2	-1.3	-1.1	1.1
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.1	-0.3	0.5	-0.0	0.0
Conditioned locomotion	0.7	0.8	1.0	0.9	0.9	-0.9	-0.9	1.0
Cocaine response after cond. corrected	1.3	1.5	2.1	1.2	0.9	-1.2	-1.4	1.4
Cocaine response after cond. not corrected	3.2	3.8	4.6	2.0	1.6	-1.8	-2.1	2.1
Cocaine response before conditioning	1.3	1.6	2.2	1.5	1.1	-1.1	-1.2	1.3
Saline control response	0.7	0.9	1.4	0.8	1.2	-0.8	-0.9	1.0
Bone: connectivity density	0.7	1.1	2.0	-1.0	-1.4	1.3	0.6	-0.6
Bone: cortical apparent density	2.2	3.0	3.7	-1.8	-1.0	1.9	1.9	-1.9
Bone: cortical area	0.4	0.7	1.5	0.9	1.2	-0.8	-0.4	0.5
Bone: cortical porosity	0.1	0.2	0.3	0.1	-0.3	-0.1	-0.6	0.6
Bone: cortical porosity	0.5	0.5	1.0	0.5	0.1	-0.4	-1.0	1.0
Bone: cortical thickness	0.1	0.1	0.3	0.1	0.6	-0.2	0.3	-0.3
Bone: cortical thickness	0.7	0.8	1.8	0.8	1.3	-1.2	-0.1	0.2
Bone: cortical tissue density	2.0	2.7	3.3	-1.7	-1.0	1.8	1.8	-1.7
Condit. Reinf. active minus inactive responses	2.4	2.7	6.4	1.3	2.5	-1.5	-1.3	1.2
Condit. Reinf. active-inactive response ratio	0.6	0.7	2.4	0.5	1.6	-0.5	-0.5	0.5
Condit. Reinf. active responses	3.1	3.8	6.7	1.8	2.6	-1.9	-1.7	1.6
Condit. Reinf. inactive responses	1.5	1.8	2.1	1.4	1.3	-1.4	-1.4	1.3
Incentive salience index mean	3.2	3.9	8.3	1.8	2.9	-1.8	-1.6	1.5
Condit. Reinf. lever presses	2.1	2.9	5.1	1.6	2.2	-1.7	-1.5	1.4
Condit. Reinf. active minus inactive responses	0.3	0.4	0.9	-0.5	0.1	0.3	0.9	-0.8
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	-0.3	0.2	-0.0	0.6	-0.5
Condit. Reinf. active responses	0.1	0.2	0.6	0.3	0.7	-0.5	0.2	-0.0
Condit. Reinf. inactive responses	0.4	0.5	0.8	0.9	0.7	-0.7	-0.5	0.6
Condit. Reinf. lever presses	1.2	1.7	3.9	1.2	2.0	-1.2	-0.8	1.0
Condit. Reinf. lever reinforcers received	0.1	0.1	0.5	0.2	0.7	-0.3	0.4	-0.2
Conditioned reinforcement - actives	0.3	0.5	0.9	0.7	0.2	-0.9	-0.7	0.7
Conditioned reinforcement - inactives	0.2	0.2	0.3	0.5	-0.3	-0.5	-0.5	0.5
Conditioned locomotion	2.3	3.0	4.1	1.8	1.1	-2.0	-1.8	1.8
Patch foraging indifference point 0 sec	0.4	0.8	1.6	0.8	1.3	-0.9	-0.7	0.7
Patch foraging indifference point AUC	0.5	0.7	1.2	-0.9	-0.6	1.1	0.8	-0.8
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	0.6	0.1	-0.5	-0.6	0.6
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.4	-0.5	0.5	0.4	-0.4
Delay disc. indifference point, 2s delay	3.3	3.7	4.2	-1.9	-2.1	1.8	2.0	-1.9
Delay disc. indifference point, 24s delay	0.7	0.7	1.8	0.6	1.3	-0.9	-0.6	0.6
Delay disc. indifference point, 4s delay	1.3	1.3	1.6	-1.1	-1.2	1.3	1.2	-1.1
Delay disc. indifference point, 8s delay	1.2	1.4	1.8	-1.3	-1.0	1.0	1.3	-1.3
Indifference point function ln k	1.9	3.2	3.8	1.8	1.8	-2.0	-1.7	1.7
Indifference point function log k	1.9	3.2	3.8	1.8	1.8	-2.0	-1.7	1.7
Patch foraging total patch changes 0 sec	0.2	0.5	1.2	0.5	1.1	-0.6	-0.4	0.5
Patch foraging total patch changes 12 sec	0.0	0.0	0.2	0.1	0.5	-0.0	0.1	0.0
Patch foraging total patch changes 18 sec	1.2	1.8	2.4	-1.2	-1.2	1.3	1.6	-1.4
Patch foraging total patch changes 24 sec	0.1	0.2	0.5	-0.3	-0.1	0.3	0.7	-0.6
Patch foraging total patch changes 6 sec	0.0	0.1	0.2	-0.2	0.3	0.4	0.1	-0.1
Patch foraging time to switch 0 sec	0.3	0.6	2.3	-0.4	-1.5	0.5	0.5	-0.5
Patch foraging water rate 0 sec	0.8	1.7	4.3	1.1	2.1	-1.0	-1.0	0.9
Patch foraging water rate 12 sec	1.6	3.4	5.5	1.7	2.4	-1.9	-1.6	1.6
Patch foraging water rate 18 sec	3.7	5.7	8.0	2.4	2.8	-2.4	-2.2	2.1
Patch foraging water rate 24 sec	1.1	1.6	1.9	1.1	1.3	-1.1	-1.4	1.3
Patch foraging water rate 6 sec	0.7	1.0	1.3	1.1	1.2	-0.9	-1.0	0.8
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.0	-0.7	-1.0	0.9	0.7	-0.7
Distance traveled before self-admin	1.4	1.8	2.9	-1.2	-1.7	1.2	1.3	-1.3
Distance traveled after self-admin	0.1	0.1	0.4	0.0	-0.7	0.2	0.0	-0.0
Extensor digitorum longus weight	0.6	2.4	5.0	1.4	2.2	-1.4	-1.3	1.2
Bone: elastic displacement	0.4	0.5	1.1	-1.0	-0.3	1.1	0.3	-0.3
Bone: elastic work	0.2	0.2	0.5	0.3	0.7	-0.3	-0.5	0.5
Bone: endosteal estimation	0.2	0.5	0.8	0.8	0.9	-0.6	-0.6	0.6
Bone: endosteal perimeter	0.3	0.6	0.9	0.9	0.8	-0.7	-0.7	0.7
Epididymis fat weight	1.7	5.9	7.2	2.6	2.1	-2.7	-2.4	2.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.2	-0.5	-0.2	0.2	-0.3
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.0	0.2	0.1	-0.1	0.1
Diff in mean of infusions in LGA sessions	1.0	1.2	1.4	1.0	1.2	-1.1	-1.1	1.1
Delay discount exponential model param	0.9	1.0	1.1	1.0	1.0	-0.9	-1.0	1.0
Extinction: sum of active levers before priming	0.3	0.3	0.5	-0.5	-0.5	0.7	0.5	-0.6
Active lever presses in extinction session 6	2.2	2.1	2.6	1.6	1.0	-1.5	-1.6	1.6
Bone: final force	0.1	0.1	0.2	-0.0	0.1	0.0	0.5	-0.5
Bone: final moment	0.1	0.2	0.3	-0.2	-0.1	0.3	0.6	-0.6
Food consumed during 24 hour testing period	2.8	3.9	6.3	1.8	2.5	-1.9	-1.8	1.8
Glucose	0.2	0.3	0.8	-0.9	-0.1	0.6	0.4	-0.4
Heart weight	0.6	0.9	1.5	1.1	1.2	-0.8	-0.7	0.8
Delay discount hyperbolic model param	1.3	1.4	1.6	1.2	1.2	-1.1	-1.3	1.2
Intermittent access intake day 1-15 change	0.4	0.9	1.1	1.0	0.5	-1.1	-1.0	1.0
Intermittent access intake escalation	0.5	1.0	1.2	1.0	0.5	-1.1	-1.0	1.0
Intermittent access intake escalation 2	1.3	1.5	1.8	1.3	0.6	-1.3	-1.3	1.3
Intermitt. access day 1 inactive lever presses	0.1	0.5	0.7	0.8	0.1	-0.7	-0.8	0.8
Intermitt. access day 15 inactive lever presses	1.8	3.6	4.3	2.1	1.2	-2.0	-2.1	2.1
Intermitt. access escalation Index	0.1	0.2	0.3	-0.5	-0.3	0.3	0.5	-0.5
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.2	0.2
Intermittent access day 15 total infusions	0.1	0.2	0.3	0.5	-0.2	-0.6	-0.5	0.5
Intermittent access terminal intake (last 3 days)	0.9	1.2	1.6	1.2	0.3	-1.2	-1.2	1.2
Intermittent access total infusions	0.2	0.2	0.2	0.4	-0.3	-0.5	-0.4	0.4
Intermittent access day 1 locomotion	0.1	0.1	0.5	-0.0	-0.7	-0.0	0.0	-0.0
Intermittent access day 15 total locomotion	0.5	0.8	1.1	1.0	0.3	-1.0	-1.0	1.0
Intermittent access total locomotion	0.6	0.8	0.9	1.0	0.4	-1.0	-1.0	1.0
Intermittent access standard deviation	0.2	0.5	0.6	0.8	-0.2	-0.7	-0.8	0.8
Left kidney weight	4.8	22.2	25.3	4.8	4.1	-4.6	-5.0	5.0
Right kidney weight	7.7	35.2	38.3	6.2	5.5	-5.7	-6.2	6.1
Cocaine induced anxiety	1.0	1.4	2.1	1.2	1.5	-1.0	-1.2	1.2
Post-drug Anxiety	1.9	2.0	3.8	1.3	1.9	-1.1	-1.3	1.3
Baseline Anxiety	0.3	0.4	0.5	-0.6	-0.5	0.7	0.6	-0.6
Tail length	0.4	1.6	2.1	-1.3	-1.5	1.4	1.0	-1.1
Length with tail	0.0	0.1	0.2	-0.2	-0.1	0.4	0.1	-0.1
Length without tail	0.2	0.5	1.0	0.7	1.0	-0.5	-0.7	0.7
Times rat made contact with spout	1.1	1.3	1.5	1.2	1.2	-1.2	-1.0	1.0
Lifetime Intake	0.2	0.3	0.3	0.5	-0.4	-0.6	-0.5	0.5
Liver weight, left	0.1	0.2	0.4	0.6	0.6	-0.3	-0.2	0.3
Liver weight, right	0.1	0.2	0.3	-0.3	-0.0	0.5	0.5	-0.5
Locomotor activity	0.1	0.2	0.3	0.3	0.1	-0.3	-0.6	0.5
Locomotor testing distance	0.7	1.2	1.6	-1.1	-1.3	1.1	1.0	-0.9
Locomotor testing rearing	0.4	0.7	0.8	-0.9	-0.9	0.9	0.8	-0.8
Locomotion in novel chamber	1.5	2.0	2.4	1.5	0.8	-1.4	-1.5	1.5
Locomotion in novel chamber post-restriction	0.1	0.2	0.6	-0.3	-0.8	0.4	0.3	-0.3
Fecal boli incidents, locomotor time 1	0.3	0.5	0.7	-0.8	-0.1	0.7	0.8	-0.8
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	0.5	0.6	-0.7	-0.5	0.5
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.4	0.6	0.6	-0.4	-0.7	0.5
Bouts of movement, locomotor time 1	0.6	0.7	1.1	0.7	0.9	-1.0	-0.8	0.7
Total resting periods, locomotor time 1	0.2	0.2	0.3	0.3	0.6	-0.6	-0.4	0.2
Rest time, locomotor task time 1	0.0	0.0	0.0	-0.0	-0.2	-0.1	-0.1	-0.1
Distance moved, locomotor task time 1	0.1	0.2	0.3	0.4	0.5	-0.4	-0.3	0.4
Vertical activity count, locomotor time 1	0.4	0.9	1.0	0.9	0.9	-1.0	-1.0	1.0
Time >=10cm from walls, locomotor time 2	1.4	2.1	2.6	1.4	1.6	-1.4	-1.5	1.4
Bouts of movement, locomotor time 2	0.2	0.3	0.4	-0.6	-0.6	0.6	0.4	-0.6
Total resting periods, locomotor time 2	0.2	0.4	0.4	-0.6	-0.6	0.6	0.5	-0.6
Rest time, locomotor task time 2	0.5	0.6	0.7	-0.8	-0.6	0.8	0.7	-0.8
Distance moved, locomotor task time 2	1.5	1.7	2.1	1.3	1.2	-1.4	-1.3	1.4
Vertical activity count, locomotor time 2	1.4	2.0	2.7	1.4	1.2	-1.6	-1.3	1.4
Light reinforcement 1	0.3	0.8	1.1	1.0	0.8	-0.6	-1.0	1.0
Light reinforcement 2	1.7	2.7	3.5	1.9	1.2	-1.6	-1.7	1.7
Bone: marrow area	0.2	0.4	0.6	0.7	0.8	-0.4	-0.5	0.5
Bone: maximum diameter	1.3	2.5	3.5	1.8	1.9	-1.5	-1.3	1.3
Bone: maximum force	0.0	0.0	0.1	0.1	0.3	-0.1	0.1	-0.2
Bone: maximum moment	0.0	0.0	0.1	-0.1	-0.0	0.2	0.3	-0.3
Mean time between licks in bursts	1.2	2.8	3.0	-1.7	-1.6	1.7	1.7	-1.7
Mean num. licks in bursts	0.2	0.2	0.8	0.4	0.9	-0.5	-0.2	0.2
Cd content in liver	0.6	0.6	0.9	-0.8	-0.6	0.8	0.8	-0.9
Co content in liver	0.2	0.3	0.6	0.1	-0.4	-0.1	-0.8	0.7
Cu content in liver	0.2	0.3	0.5	-0.1	-0.6	0.1	0.7	-0.7
Fe content in liver	0.1	0.2	0.3	-0.4	-0.4	0.3	0.5	-0.5
K content in liver	0.1	0.1	0.2	0.0	-0.5	0.4	0.0	0.1
Mg content in liver	0.8	0.8	1.4	-0.7	-1.2	1.2	0.6	-0.6
Mn content in liver	0.1	0.2	0.5	0.1	-0.7	0.1	-0.4	0.3
Na content in liver	4.3	4.6	5.6	-2.0	-1.9	2.1	2.4	-2.3
Rb content in liver	0.0	0.0	0.2	0.1	0.4	0.1	0.0	0.0
Se content in liver	0.4	0.5	0.8	0.8	0.6	-0.4	-0.9	0.8
Sr content in liver	1.3	1.1	1.2	-1.0	-1.1	1.0	1.1	-1.1
Zn content in liver	0.4	0.4	0.7	-0.6	-0.7	0.9	0.6	-0.5
Bone: minimum diameter	0.3	0.5	0.8	0.8	0.8	-0.9	-0.5	0.5
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.5	0.0	-0.5	-0.7	0.7
Time in novel zone, hab. session 1	0.8	0.8	1.1	-1.1	-0.6	0.9	0.8	-0.8
Total zone transitions, hab. session 1	3.0	4.1	4.6	-2.1	-1.8	2.0	2.1	-2.2
Total locomotion distance, hab. session 1	0.3	0.4	0.7	-0.7	-0.6	0.8	0.5	-0.5
Locomotion velocity, hab. session 1	0.4	0.6	0.8	-0.7	-0.6	0.9	0.7	-0.7
Time in familiar zone, hab. session 2	1.9	2.0	2.2	1.4	1.2	-1.5	-1.5	1.5
Time in novel zone, hab. session 2	2.1	2.1	2.6	-1.6	-1.2	1.6	1.4	-1.4
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.3	0.4	-0.3	-0.2	0.2
Total locomotion distance, hab. session 2	0.7	0.9	1.2	1.0	0.9	-0.8	-1.1	1.1
Locomotion velocity, hab. session 2	0.6	0.8	1.0	0.9	0.8	-0.7	-1.0	1.0
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.2	0.3	0.3	0.1	-0.1
Novelty place preference	0.0	0.0	0.1	-0.1	0.3	0.1	-0.2	0.2
Time in novel zone, NPP test	0.0	0.0	0.1	-0.1	0.3	0.2	-0.1	0.1
Total zone transitions, NPP test	0.7	1.0	1.3	-1.0	-0.5	1.1	1.1	-1.2
Total locomotion distance, NPP test	0.0	0.0	0.1	-0.1	0.1	0.3	0.0	-0.1
Locomotion velocity, NPP test	0.0	0.0	0.1	0.1	0.0	0.2	-0.1	-0.0
Intraocular pressure	0.0	0.1	0.1	-0.2	0.4	0.1	0.2	-0.3
Delta distance traveled before/after self-admin	3.8	4.0	4.7	2.2	1.7	-1.9	-2.1	2.1
Delta ambulatory time before/after self-admin	2.4	3.0	3.9	1.7	2.0	-1.5	-1.7	1.7
Parametrial fat weight	0.2	0.4	1.0	1.0	-0.0	-0.8	-0.4	0.5
Pavlov. Cond. lever latency	1.5	1.8	2.2	-1.5	-1.4	1.4	1.3	-1.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.1	0.4	0.0	0.4	-0.5
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	0.4	0.8	-0.3	0.1	-0.2
Pavlov. Cond. index score	0.1	0.2	0.5	0.5	0.7	-0.5	-0.1	0.0
Pavlov. Cond. latency score	0.3	0.4	0.8	0.7	0.9	-0.7	-0.3	0.3
Pavlov. Cond. lever contacts	1.4	1.7	2.2	1.5	1.3	-1.4	-1.2	1.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	0.3	-0.4	-0.2	-0.6	0.7
Pavlov. Cond. intertrial magazine entries	1.2	1.4	1.9	1.0	1.4	-1.2	-1.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.3	0.5	-0.3	0.1	-0.2
Pavlov. Cond. response bias	0.3	0.4	1.0	0.6	1.0	-0.7	-0.4	0.4
Pavlov. Cond. lever latency	1.8	2.5	3.5	-1.6	-1.9	1.6	1.3	-1.4
Pavlov. Cond. magazine entry latency	1.1	1.3	2.2	1.4	1.5	-1.1	-0.7	0.8
Pavlov. Cond. change in total contacts	0.1	0.2	0.7	0.2	0.8	-0.4	0.2	-0.0
Pavlov. Cond. index score	1.1	1.5	2.6	1.3	1.6	-1.2	-0.9	1.0
Pavlov. Cond. latency score	1.9	2.5	3.7	1.7	1.9	-1.6	-1.2	1.3
Pavlov. Cond. lever contacts	1.9	2.7	3.9	1.6	2.0	-1.7	-1.4	1.5
Pavlov. Cond. magazine entry number	1.4	1.7	2.9	-1.5	-1.7	1.3	0.9	-1.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.9	-0.3	-1.0	0.4	-0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	2.9	1.4	1.7	-1.3	-0.9	1.1
Pavlov. Cond. response bias	0.7	0.9	1.5	1.0	1.2	-1.0	-0.7	0.8
Time in closed arm before self-admin	0.9	1.1	1.9	-1.0	-0.9	1.4	1.0	-0.9
Time in closed arm after self-admin	0.4	0.4	1.0	-0.5	-1.0	0.4	0.5	-0.5
Time in open arm before self-admin	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.1	-0.1
Time in open arm after self-admin	0.1	0.1	0.4	0.2	0.7	-0.2	-0.1	0.1
Bone: periosteal estimation	0.4	0.8	1.6	1.1	1.3	-0.9	-0.6	0.6
Bone: periosteal perimeter	0.7	1.3	2.0	1.3	1.4	-1.1	-1.0	0.9
Bone: post-yield work	0.7	1.1	1.5	-0.8	-1.0	0.7	1.2	-1.2
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.2	-0.3	-0.2	-0.2	0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.2	0.1	-0.5	-0.1	-0.1	0.1
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.3	-0.4	-0.2	-0.3	0.3
Progressive ratio test 2 active lever presses	0.8	0.9	1.1	1.1	0.5	-0.9	-1.1	1.1
Progressive ratio test 2 breakpoint	0.5	0.6	0.8	0.9	0.3	-0.8	-0.9	0.9
Progressive ratio test 2 inactive lever presses	0.6	0.9	1.1	1.1	0.5	-0.9	-1.1	1.1
Incentive Sensitization - Responses	0.9	1.3	1.3	1.2	1.1	-1.1	-1.2	1.2
Incentive Sensitization - Breakpoint	0.9	1.1	1.2	1.1	1.1	-1.0	-1.1	1.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.3	-0.4	-0.2	-0.3	0.3
Progressive ratio	0.2	0.3	0.4	0.7	0.1	-0.6	-0.7	0.7
Food seeking constrained by brief footshock	2.6	3.2	3.5	1.9	1.5	-1.8	-1.9	1.9
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.0	0.3	-0.1	0.0	-0.0
Retroperitoneal fat weight	2.2	9.4	10.9	3.3	2.5	-3.3	-3.1	3.1
Reaction time number correct	0.4	0.7	1.0	-0.7	-0.6	1.0	0.9	-0.9
Reaction time mean minus median	0.1	0.3	1.2	0.3	1.1	-0.3	-0.4	0.4
Reaction time mean minus median AUC	0.2	0.4	1.1	0.4	1.0	-0.4	-0.6	0.6
Reaction time num false alarms	0.1	0.1	0.3	-0.1	-0.5	0.2	0.2	-0.2
Reaction time num false alarms AUC	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1	0.0
Reaction time trials correct on left	0.4	0.7	1.0	-0.7	-0.6	1.0	0.9	-0.9
Reaction time trials on left	0.4	0.7	1.0	-0.7	-0.5	1.0	0.9	-0.9
Reaction time mean	0.0	0.0	0.1	0.0	0.3	0.0	0.2	-0.3
Reaction time mean AUC	0.0	0.1	0.2	-0.1	0.2	0.2	0.3	-0.4
Median of all reaction times	0.0	0.0	0.1	0.1	0.1	0.0	0.2	-0.4
Reaction time omissions	0.1	0.2	0.2	-0.4	0.3	0.3	0.5	-0.5
Reaction time false alarm rate	0.1	0.1	0.2	0.3	0.1	-0.4	-0.3	0.3
Reaction time premature initiation rate	2.3	3.2	3.7	1.7	1.9	-1.8	-1.8	1.7
Reaction time premature initiations	0.6	1.1	1.8	1.0	1.3	-0.9	-1.0	0.9
Std. dev. reaction times	0.2	0.4	1.3	0.5	1.1	-0.5	-0.4	0.4
Reaction time trials completed	0.4	0.7	1.0	-0.7	-0.5	1.0	0.9	-0.9
Reaction time trials AUC	0.2	0.4	0.7	-0.5	-0.3	0.8	0.7	-0.7
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.2	0.1	-0.3	-0.3	0.3
Run reversals in cocaine runway, males	0.9	0.9	1.0	-1.0	-0.5	1.0	1.0	-1.0
Latency to leave start box in cocaine runway	2.0	2.3	2.6	1.6	1.3	-1.4	-1.6	1.6
Latency to leave start box in cocaine runway, F	4.2	4.8	5.2	2.2	2.2	-2.0	-2.3	2.3
Latency to leave start box in cocaine runway, M	0.2	0.2	0.6	-0.2	-0.8	0.2	0.2	-0.2
Std. dev. time between licks in bursts	0.4	0.5	0.9	0.6	0.4	-0.7	-0.9	0.8
Total sessions with >9 infusions	0.2	0.3	0.3	0.6	-0.4	-0.6	-0.6	0.6
Short access day 1 total inactive lever presses	4.3	5.7	6.0	2.4	2.2	-2.3	-2.4	2.4
Short access day 10 total inactive lever presses	3.3	8.0	9.6	2.9	2.3	-3.1	-2.9	2.9
Short access day 1 total infusions	0.9	1.2	1.7	1.2	0.4	-1.3	-1.2	1.2
Short access day 10 total infusions	0.8	1.0	1.2	1.1	-0.0	-1.1	-1.1	1.1
Short access total infusions	0.6	0.8	1.0	1.0	-0.2	-1.0	-1.0	1.0
Short access day 1 locomotion	0.9	1.1	1.5	1.2	0.2	-1.1	-1.2	1.2
Short access day 10 total locomotion	0.6	1.2	1.8	1.2	0.1	-1.3	-1.2	1.2
Short access total locomotion	0.6	0.7	0.9	0.9	-0.4	-1.0	-0.9	0.9
One hour access (0.3 mA shock)	0.6	0.7	0.9	0.9	-0.0	-0.9	-0.9	0.9
Compulsive drug intake	0.1	0.1	0.4	-0.1	0.6	0.1	0.1	-0.1
One hour access (shock baseline)	0.3	0.4	0.5	0.7	-0.4	-0.7	-0.7	0.7
Social response proportion	0.2	0.2	0.4	-0.4	0.0	0.2	0.6	-0.6
Social responses	0.1	0.1	0.1	-0.2	0.3	0.2	0.3	-0.3
Social time	0.5	0.7	1.5	0.6	1.2	-0.8	-0.7	0.8
Soleus weight	1.2	3.7	4.3	2.0	2.1	-1.8	-1.9	1.8
Bone: stiffness	0.1	0.2	0.4	-0.2	-0.4	0.2	0.6	-0.6
Tibialis anterior weight	0.1	0.4	0.7	0.8	0.7	-0.4	-0.4	0.5
Time to tail flick, vehicle, before self-admin	1.7	1.8	2.2	1.3	1.5	-1.2	-1.4	1.4
Time to tail flick, vehicle, after self-admin	0.6	0.8	1.2	0.9	1.1	-0.7	-0.9	0.9
Time to tail flick, test, before self-admin	0.5	0.5	0.6	0.8	-0.3	-0.8	-0.7	0.7
Time to tail flick, test, after self-admin	3.6	3.7	4.2	2.0	1.5	-2.0	-2.1	2.0
Delta time to tail flick, vehicle, before/after SA	0.6	0.5	0.7	-0.8	-0.3	0.8	0.8	-0.8
Delta time to tail flick, test, before/after SA	0.5	0.5	1.6	0.4	1.2	-0.4	-0.6	0.5
Tibia length	1.6	4.5	6.1	-1.9	-1.9	1.8	2.4	-2.5
Ambulatory time before self-admin	0.3	0.5	1.2	-0.5	-1.1	0.5	0.6	-0.5
Ambulatory time after self-admin	0.2	0.2	0.3	0.6	0.3	-0.3	-0.5	0.5
Bone: tissue strength	1.4	1.4	2.1	-1.2	-1.4	1.5	0.8	-0.8
Total heroin consumption	0.0	0.1	0.1	0.3	0.2	-0.2	-0.3	0.2
Bone: trabecular number	0.9	1.4	2.5	-1.3	-1.6	1.5	0.6	-0.6
Bone: trabecular spacing	1.7	2.3	3.2	1.7	1.2	-1.8	-1.4	1.4
Bone: trabecular thickness	0.2	0.2	0.4	-0.4	-0.6	0.5	0.3	-0.2
Bone: trabecular tissue density	1.9	2.7	3.9	-1.5	-1.3	1.4	2.0	-2.0
Water consumed over 24 hours	0.1	0.2	0.3	0.3	0.5	-0.4	-0.5	0.4
Number of responses in last shaping day	0.2	0.2	0.7	-0.3	-0.9	0.3	0.3	-0.3