Pik3ca

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Pik3ca	0.18	0.08	0.0e+00	0.16	0.18	0.18	0.18	3.3e-15	2.2e-16	1.3e-16	3.2e-16
2	Adipose	gene expression	Pik3ca	0.1	0.05	3.1e-11	0.07	0.09	0.09	0.09	1.1e-08	3.0e-10	3.1e-10	3.6e-10
3	PL	gene expression	Pik3ca	0.12	0.06	4.5e-15	0.14	0.14	0.12	0.12	6.3e-15	1.1e-14	3.6e-13	2.5e-13
4	LHb	mRNA stability	Pik3ca	0.17	0.1	3.2e-04	0.16	0.21	0.18	0.21	1.6e-04	9.5e-06	4.7e-05	1.3e-05
5	Liver	mRNA stability	Pik3ca	0.1	0.06	8.1e-10	0.05	0.07	0.05	0.05	1.8e-06	3.3e-08	2.8e-06	1.9e-06
6	NAcc	mRNA stability	Pik3ca	0.01	0.01	5.0e-03	0	0.01	0.01	0.01	6.7e-02	1.1e-02	3.3e-02	2.1e-02
7	IL	mRNA stability	Pik3ca	0.24	0.13	1.5e-04	0.14	0.19	0.12	0.16	2.7e-04	2.2e-05	7.0e-04	1.5e-04
8	Brain	mRNA stability	Pik3ca	0.11	0.06	9.2e-11	0.09	0.1	0.1	0.09	2.5e-08	7.7e-10	1.7e-09	2.6e-08
9	PL	mRNA stability	Pik3ca	0.04	0.02	1.6e-05	0.04	0.04	0.05	0.04	3.4e-05	3.2e-05	7.2e-06	2.2e-05
10	NAcc	gene expression	Pik3ca	0.09	0.06	2.0e-12	0.08	0.09	0.09	0.09	3.5e-12	4.8e-13	5.5e-13	7.2e-13
11	Liver	gene expression	Pik3ca	0.04	0.03	3.0e-05	0.03	0.02	0.01	0.01	3.1e-04	3.8e-03	9.6e-03	1.4e-02
12	BLA	gene expression	Pik3ca	0.1	0.06	3.0e-05	0.08	0.08	0.07	0.08	4.3e-05	7.6e-05	8.0e-05	4.4e-05
13	RMTg	mRNA stability	Pik3ca	0.4	0.19	2.1e-05	0.17	0.17	0.15	0.16	3.5e-05	2.8e-05	9.4e-05	5.5e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12	13
Bone: apparent density	3.2	5.6	6.6	2.5	2.5	2.6	-2.5	-2.5	-2.4	-2.5	-2.2	-2.0	2.5	2.4	2.3	-1.7
Area under the delay curve	1.0	1.1	2.3	1.0	1.0	1.0	-1.1	-1.0	-1.1	-0.8	-1.1	-1.5	0.9	1.0	1.0	-1.1
BMI with tail	0.3	1.1	1.9	0.8	0.9	1.1	-1.1	-0.6	-1.2	-0.4	-1.2	-1.4	0.6	1.0	1.2	-1.3
BMI without tail	0.4	1.2	1.9	0.9	1.0	1.2	-1.1	-0.8	-1.2	-0.6	-1.3	-1.3	0.7	1.0	1.1	-1.4
Body weight	0.1	0.3	1.0	0.4	0.5	0.4	-0.6	-0.3	-0.6	-0.3	-0.5	-1.0	0.5	0.4	0.7	-0.3
Weight adjusted by age	0.9	1.4	2.1	-0.9	-1.1	-1.1	1.3	0.8	1.4	0.6	1.4	1.3	-0.8	-1.3	-1.4	1.4
Bone surface	0.2	0.3	0.9	0.6	0.6	0.6	-0.5	-0.7	-0.3	-0.9	-0.1	0.0	0.8	0.5	0.3	0.5
Bone volume	0.3	0.6	1.7	0.9	0.8	0.8	-0.7	-1.0	-0.5	-1.3	-0.2	-0.0	1.2	0.7	0.5	0.5
Breakpoint value in progressive ratio session	2.1	2.5	3.6	1.4	1.4	1.6	-1.6	-1.5	-1.7	-1.2	-1.7	-1.9	1.3	1.6	1.6	-1.9
Number of licking bursts	0.8	1.3	3.2	0.9	1.0	1.3	-1.2	-0.8	-1.4	-0.3	-1.6	-1.2	0.5	1.1	1.0	-1.8
Context. condit. distance diff. score	4.7	5.7	7.1	2.4	2.6	2.3	-2.4	-2.6	-2.3	-2.6	-2.2	-2.0	2.7	2.3	2.6	-2.0
Locomotion velocity, session 1	2.0	2.1	3.8	-1.8	-1.6	-1.4	1.3	1.8	1.2	1.9	1.1	1.3	-1.7	-1.4	-1.1	0.7
Locomotion distance, session 1	0.6	0.7	1.7	-1.1	-0.9	-0.7	0.7	1.2	0.5	1.3	0.5	0.5	-1.2	-0.9	-0.7	0.5
Locomotion velocity, session 2	3.6	4.2	7.4	-2.3	-2.3	-1.8	1.9	2.4	1.7	2.7	1.5	1.7	-2.6	-2.0	-1.9	0.9
Locomotion distance, session 2	1.3	1.8	2.6	-1.4	-1.5	-1.2	1.3	1.6	1.2	1.6	1.1	1.2	-1.6	-1.4	-1.3	1.0
Locomotion velocity, session 3	0.0	0.0	0.1	-0.2	-0.2	-0.0	0.1	0.2	0.1	0.2	0.1	0.2	-0.2	-0.2	-0.1	0.2
Locomotion distance, session 3	0.4	0.5	0.9	-0.8	-0.8	-0.5	0.7	0.8	0.5	1.0	0.4	0.4	-1.0	-0.8	-0.7	0.2
Stereotopy head waving bouts, day 3	0.0	0.0	0.2	-0.2	-0.2	-0.3	0.2	0.2	0.2	0.2	0.2	0.5	-0.2	-0.1	-0.1	-0.1
Stereotopy head waving duration, day 3	0.7	0.9	1.3	0.9	0.9	0.9	-0.9	-0.9	-1.0	-0.8	-1.0	-0.8	0.9	1.0	1.0	-1.1
Locomotion velocity, session 7	0.9	0.9	2.6	-0.8	-0.9	-0.7	0.9	0.8	1.0	0.5	1.1	1.0	-0.7	-1.0	-1.0	1.6
Locomotion distance, session 7	0.7	0.9	1.6	-0.8	-0.9	-0.9	1.0	0.8	1.0	0.6	1.1	1.1	-0.7	-1.0	-1.0	1.3
Stereotopy head waving bouts, day 7	0.4	0.4	1.1	0.4	0.5	0.7	-0.6	-0.3	-0.8	0.1	-1.0	-0.8	0.1	0.4	0.6	-1.1
Stereotopy head waving duration, day 7	1.1	1.3	2.3	0.9	1.0	1.2	-1.2	-0.8	-1.4	-0.5	-1.5	-1.3	0.7	1.0	1.2	-1.5
Locomotion velocity, session 8	1.7	2.0	2.9	1.3	1.3	1.5	-1.5	-1.2	-1.6	-0.9	-1.7	-1.6	1.1	1.4	1.4	-1.6
Locomotion distance, session 8	0.7	1.1	1.6	1.0	1.2	1.0	-1.1	-1.1	-1.0	-1.2	-0.8	-0.7	1.3	1.0	1.3	-0.6
Degree of sensitization distance	0.7	0.8	1.8	-0.6	-0.7	-0.9	0.9	0.5	1.1	0.1	1.2	1.3	-0.3	-0.8	-0.8	1.4
Degree of sensitization stereotypy	1.7	1.8	3.0	1.1	1.2	1.5	-1.4	-1.0	-1.6	-0.6	-1.7	-1.7	0.8	1.2	1.3	-1.7
Conditioned locomotion	0.1	0.1	0.4	0.4	0.4	0.2	-0.2	-0.5	-0.1	-0.6	-0.0	0.2	0.5	0.2	0.3	0.0
Cocaine response after cond. corrected	0.0	0.0	0.1	0.2	0.2	-0.2	0.0	-0.2	0.1	-0.3	0.1	0.0	0.3	0.0	0.0	0.1
Cocaine response after cond. not corrected	0.2	0.3	0.6	-0.4	-0.4	-0.7	0.5	0.4	0.7	0.2	0.7	0.6	-0.2	-0.5	-0.5	0.8
Cocaine response before conditioning	0.0	0.1	0.3	-0.2	-0.2	-0.1	0.1	0.2	0.2	0.1	0.3	0.2	-0.1	-0.2	-0.1	0.5
Saline control response	0.2	0.2	0.6	-0.4	-0.4	-0.5	0.4	0.3	0.6	0.0	0.7	0.8	-0.0	-0.5	-0.2	0.8
Bone: connectivity density	1.8	2.8	3.5	1.7	1.7	1.9	-1.8	-1.6	-1.8	-1.5	-1.7	-1.6	1.6	1.8	1.7	-1.6
Bone: cortical apparent density	0.1	0.1	0.2	0.3	0.3	0.4	-0.3	-0.3	-0.3	-0.3	-0.3	-0.0	0.3	0.4	0.3	-0.4
Bone: cortical area	0.2	0.3	1.1	0.3	0.3	0.1	-0.1	-0.6	0.2	-1.0	0.5	0.6	0.9	0.2	0.2	1.0
Bone: cortical porosity	0.1	0.1	0.1	0.3	0.2	0.3	-0.2	-0.4	-0.2	-0.4	-0.1	-0.2	0.3	0.2	0.2	-0.2
Bone: cortical porosity	0.1	0.1	0.4	0.4	0.3	0.3	-0.2	-0.5	-0.1	-0.6	-0.0	-0.2	0.6	0.3	0.3	0.1
Bone: cortical thickness	0.3	0.5	1.7	0.7	0.7	0.4	-0.5	-0.9	-0.2	-1.3	0.0	0.1	1.2	0.6	0.7	0.4
Bone: cortical thickness	0.2	0.3	0.8	-0.7	-0.6	-0.5	0.4	0.7	0.3	0.9	0.2	0.3	-0.7	-0.4	-0.3	-0.2
Bone: cortical tissue density	0.1	0.1	0.2	0.3	0.3	0.5	-0.3	-0.3	-0.3	-0.3	-0.3	-0.0	0.3	0.4	0.3	-0.5
Condit. Reinf. active minus inactive responses	1.9	2.1	2.4	-1.5	-1.5	-1.4	1.5	1.5	1.5	1.4	1.5	1.1	-1.4	-1.5	-1.5	1.5
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.1	-1.3	-1.2	-1.3	1.3	1.2	1.4	1.0	1.4	1.0	-1.1	-1.4	-1.3	1.4
Condit. Reinf. active responses	1.1	1.3	1.7	-1.3	-1.3	-1.0	1.2	1.2	1.1	1.1	1.2	0.7	-1.1	-1.1	-1.2	1.3
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.0	-0.0	0.3	-0.2	-0.0	-0.2	0.1	-0.1	-0.2	0.0	0.3	0.0	0.1
Incentive salience index mean	2.1	2.6	2.9	-1.7	-1.7	-1.6	1.6	1.7	1.7	1.5	1.7	1.3	-1.5	-1.6	-1.6	1.7
Condit. Reinf. lever presses	0.7	1.0	1.3	-1.1	-1.1	-1.0	0.9	1.1	1.0	1.1	1.0	0.9	-1.0	-0.8	-0.9	1.1
Condit. Reinf. active minus inactive responses	1.0	1.4	2.9	-1.1	-1.1	-0.9	1.2	1.0	1.2	0.8	1.4	0.8	-0.9	-1.4	-1.2	1.7
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.8	-1.0	-0.9	-0.9	1.0	0.8	1.1	0.6	1.2	0.6	-0.7	-1.2	-1.0	1.3
Condit. Reinf. active responses	2.9	4.0	6.7	-2.0	-2.0	-1.7	2.0	1.9	2.0	1.6	2.2	1.9	-1.8	-2.1	-2.1	2.6
Condit. Reinf. inactive responses	1.9	2.4	3.1	-1.7	-1.7	-1.5	1.5	1.7	1.4	1.8	1.3	1.5	-1.8	-1.5	-1.6	1.3
Condit. Reinf. lever presses	0.4	0.5	1.6	-0.5	-0.6	-0.5	0.6	0.6	0.7	0.4	0.8	0.4	-0.5	-0.8	-0.9	1.3
Condit. Reinf. lever reinforcers received	2.7	3.7	6.5	-1.9	-2.0	-1.7	1.9	1.8	2.0	1.6	2.1	1.8	-1.7	-2.0	-2.0	2.6
Conditioned reinforcement - actives	0.4	0.7	1.2	-1.1	-1.0	-1.0	0.9	0.9	0.8	1.1	0.7	0.9	-0.9	-0.7	-0.7	-0.0
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.3	-0.2	-0.3	0.2	0.2	0.1	0.3	0.1	0.1	-0.2	-0.1	-0.1	-0.2
Conditioned locomotion	0.6	0.8	1.6	-1.2	-1.1	-1.0	0.9	1.0	0.8	1.3	0.7	0.7	-1.1	-0.7	-0.8	-0.0
Patch foraging indifference point 0 sec	0.9	1.7	2.4	1.3	1.2	1.6	-1.3	-1.2	-1.4	-0.9	-1.5	-1.5	0.9	1.3	1.0	-1.4
Patch foraging indifference point AUC	0.8	1.2	2.3	0.9	0.9	1.3	-1.3	-0.5	-1.4	-0.2	-1.5	-1.5	0.4	0.9	1.1	-1.4
Delay disc. indifference point, 0s delay	0.3	0.3	0.6	-0.6	-0.6	-0.6	0.5	0.6	0.6	0.5	0.7	0.5	-0.5	-0.5	-0.5	0.8
Delay disc. indifference point, 16s delay	1.6	1.8	3.1	1.1	1.3	1.2	-1.3	-1.4	-1.3	-1.3	-1.3	-1.8	1.3	1.3	1.3	-1.4
Delay disc. indifference point, 2s delay	0.7	0.8	1.3	1.0	0.9	0.7	-1.0	-0.8	-0.9	-0.8	-0.9	-1.1	0.8	0.9	0.9	-0.6
Delay disc. indifference point, 24s delay	1.4	1.6	2.0	1.2	1.3	1.2	-1.2	-1.4	-1.2	-1.3	-1.2	-1.4	1.3	1.2	1.2	-1.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.6	0.5	0.4	0.4	-0.5	-0.3	-0.6	-0.2	-0.6	-0.7	0.3	0.5	0.6	-0.8
Delay disc. indifference point, 8s delay	0.2	0.2	0.8	0.4	0.4	0.4	-0.4	-0.2	-0.5	-0.1	-0.6	-0.9	0.1	0.3	0.3	-0.5
Indifference point function ln k	0.6	1.0	1.9	-0.8	-0.8	-1.1	1.2	0.5	1.3	0.2	1.4	1.2	-0.4	-0.9	-1.1	1.4
Indifference point function log k	0.6	1.0	1.9	-0.8	-0.8	-1.1	1.2	0.5	1.3	0.2	1.4	1.2	-0.4	-0.9	-1.1	1.4
Patch foraging total patch changes 0 sec	0.8	1.5	2.2	1.2	1.1	1.5	-1.2	-1.1	-1.4	-0.8	-1.5	-1.5	0.8	1.2	0.9	-1.3
Patch foraging total patch changes 12 sec	0.8	1.1	1.9	1.1	0.9	1.4	-1.1	-0.8	-1.2	-0.4	-1.4	-1.3	0.5	1.0	0.7	-1.2
Patch foraging total patch changes 18 sec	0.5	0.8	1.6	0.8	0.7	1.1	-0.9	-0.5	-1.1	-0.1	-1.3	-1.3	0.2	0.8	0.6	-1.1
Patch foraging total patch changes 24 sec	2.8	4.8	6.3	2.2	2.1	2.4	-2.3	-1.9	-2.4	-1.6	-2.5	-2.5	1.8	2.3	2.0	-2.2
Patch foraging total patch changes 6 sec	3.4	5.2	7.6	2.3	2.2	2.8	-2.4	-2.1	-2.6	-1.6	-2.7	-2.4	1.6	2.3	2.0	-2.4
Patch foraging time to switch 0 sec	0.0	0.0	0.1	-0.2	-0.2	-0.3	0.3	0.0	0.3	-0.1	0.4	0.3	0.0	-0.1	-0.2	0.1
Patch foraging water rate 0 sec	0.3	0.6	1.0	0.9	0.8	1.0	-0.8	-0.7	-0.8	-0.7	-0.8	-0.5	0.7	0.8	0.5	-0.3
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.1	0.0	0.0	0.1	-0.3	0.1	-0.3	0.1	0.4	0.2	0.2	-0.2	0.1
Patch foraging water rate 18 sec	0.3	0.4	0.8	-0.6	-0.7	-0.6	0.7	0.7	0.5	0.8	0.5	0.9	-0.8	-0.5	-0.8	0.4
Patch foraging water rate 24 sec	1.0	1.4	2.2	1.2	1.2	1.5	-1.3	-1.3	-1.3	-1.1	-1.3	-1.0	1.1	1.3	1.0	-1.0
Patch foraging water rate 6 sec	0.0	0.0	0.1	0.2	0.1	0.2	-0.1	-0.2	-0.1	-0.1	-0.1	-0.0	0.1	0.3	-0.1	-0.1
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	1.7	0.8	1.0	0.7	-0.8	-1.2	-0.7	-1.2	-0.6	-0.9	1.3	1.0	1.3	-1.2
Distance traveled before self-admin	1.4	1.8	3.4	1.4	1.3	1.4	-1.4	-1.1	-1.5	-0.9	-1.5	-1.8	1.0	1.3	1.3	-1.3
Distance traveled after self-admin	0.2	0.2	1.3	0.4	0.2	0.6	-0.4	-0.2	-0.6	0.1	-0.6	-1.1	-0.1	0.2	0.1	-0.4
Extensor digitorum longus weight	0.1	0.2	0.9	0.1	0.3	0.6	-0.6	-0.1	-0.6	0.1	-0.6	-0.9	0.1	0.5	0.5	-0.4
Bone: elastic displacement	0.1	0.1	0.2	0.2	0.2	-0.0	-0.0	-0.4	0.0	-0.4	-0.0	-0.3	0.4	0.2	0.3	-0.3
Bone: elastic work	0.5	0.6	1.8	-0.5	-0.5	-0.7	0.8	0.2	1.0	-0.2	1.2	1.1	0.0	-0.7	-0.6	1.3
Bone: endosteal estimation	0.4	1.0	3.1	-0.8	-0.9	-0.8	0.9	0.7	1.0	0.4	1.3	1.1	-0.5	-0.9	-1.0	1.8
Bone: endosteal perimeter	0.6	1.3	2.2	-1.1	-1.1	-1.0	1.1	1.0	1.1	0.9	1.2	1.3	-0.9	-1.1	-1.2	1.5
Epididymis fat weight	0.1	0.4	0.9	-0.5	-0.6	-0.7	0.5	0.8	0.6	0.6	0.6	0.2	-0.6	-0.6	-0.6	0.9
Delta time in closed arm before/after self-admin	1.5	1.4	2.2	1.2	1.3	1.0	-1.2	-1.3	-1.0	-1.5	-0.8	-0.9	1.5	1.3	1.3	-0.5
Delta time in open arm before/after self-admin	0.3	0.3	0.6	-0.4	-0.6	-0.4	0.5	0.6	0.4	0.7	0.2	-0.1	-0.8	-0.6	-0.7	0.1
Diff in mean of infusions in LGA sessions	0.1	0.2	0.5	0.5	0.4	0.3	-0.3	-0.5	-0.2	-0.6	-0.1	-0.7	0.6	0.3	0.2	0.1
Delay discount exponential model param	1.2	1.4	2.6	-1.1	-1.1	-1.1	1.2	1.0	1.2	0.9	1.3	1.6	-1.0	-1.1	-1.1	1.3
Extinction: sum of active levers before priming	1.1	1.2	2.9	-0.8	-1.0	-1.0	1.2	0.7	1.3	0.5	1.4	0.4	-0.7	-1.3	-1.3	1.7
Active lever presses in extinction session 6	0.3	0.3	0.8	0.4	0.5	0.5	-0.5	-0.5	-0.5	-0.4	-0.6	-0.7	0.4	0.6	0.5	-0.9
Bone: final force	0.2	0.4	1.8	-0.3	-0.4	-0.4	0.5	0.1	0.7	-0.2	1.0	0.9	0.1	-0.4	-0.3	1.4
Bone: final moment	0.2	0.2	1.4	-0.0	-0.1	-0.1	0.3	-0.2	0.5	-0.5	0.8	0.6	0.4	-0.1	-0.1	1.2
Food consumed during 24 hour testing period	0.0	0.0	0.1	0.0	0.0	-0.1	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1	-0.1	-0.0	0.2
Glucose	1.0	1.5	2.0	-1.2	-1.3	-1.1	1.3	1.2	1.2	1.2	1.1	1.3	-1.3	-1.3	-1.4	0.9
Heart weight	0.0	0.1	0.4	0.1	0.1	0.2	-0.2	-0.1	-0.2	-0.1	-0.2	-0.6	0.2	0.1	0.4	-0.2
Delay discount hyperbolic model param	1.1	1.2	2.4	-1.1	-1.1	-1.0	1.2	1.0	1.2	0.8	1.2	1.5	-0.9	-1.1	-1.1	1.2
Intermittent access intake day 1-15 change	0.4	0.8	1.2	0.8	0.8	1.0	-1.0	-0.7	-1.1	-0.5	-1.1	-1.1	0.6	0.9	0.9	-1.1
Intermittent access intake escalation	0.5	1.1	2.1	0.8	0.9	1.1	-1.0	-0.8	-1.2	-0.4	-1.3	-1.3	0.6	1.0	1.0	-1.5
Intermittent access intake escalation 2	0.0	0.0	0.1	0.2	0.1	0.2	-0.1	-0.2	-0.1	-0.2	-0.1	-0.1	0.1	-0.0	-0.1	0.2
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.2	-0.1	-0.0	-0.1	0.1	-0.1	0.2	-0.2	0.3	0.5	0.2	0.1	-0.0	0.2
Intermitt. access day 15 inactive lever presses	0.4	0.7	1.5	-1.0	-1.0	-0.9	0.9	1.0	0.7	1.2	0.5	0.5	-1.1	-0.7	-0.9	0.1
Intermitt. access escalation Index	0.1	0.1	0.4	0.3	0.4	0.2	-0.2	-0.5	-0.1	-0.6	0.0	0.1	0.6	0.4	0.3	0.0
Intermittent access day 1 total infusions	4.5	7.3	8.4	-2.9	-2.8	-2.9	2.8	2.7	2.7	2.7	2.6	2.8	-2.7	-2.7	-2.5	2.0
Intermittent access day 15 total infusions	0.3	0.4	1.4	-0.9	-0.7	-0.6	0.5	0.8	0.3	1.2	0.1	0.2	-0.9	-0.5	-0.4	-0.6
Intermittent access terminal intake (last 3 days)	1.4	1.9	2.4	-1.6	-1.5	-1.4	1.4	1.5	1.3	1.6	1.2	1.3	-1.5	-1.3	-1.2	0.7
Intermittent access total infusions	1.8	2.1	3.9	-1.8	-1.7	-1.5	1.5	1.7	1.2	2.0	1.0	1.2	-1.8	-1.3	-1.2	0.2
Intermittent access day 1 locomotion	2.4	3.0	3.7	-1.9	-1.9	-1.8	1.8	1.7	1.7	1.8	1.7	1.8	-1.7	-1.7	-1.6	1.1
Intermittent access day 15 total locomotion	0.1	0.1	0.6	-0.2	-0.1	0.1	-0.0	0.1	-0.3	0.4	-0.3	-0.4	-0.2	0.2	0.1	-0.8
Intermittent access total locomotion	0.4	0.5	1.5	-0.9	-0.8	-0.6	0.6	0.8	0.3	1.2	0.2	0.2	-1.0	-0.5	-0.4	-0.5
Intermittent access standard deviation	0.1	0.2	0.4	0.5	0.5	0.5	-0.5	-0.5	-0.5	-0.4	-0.6	-0.7	0.4	0.4	0.4	-0.4
Left kidney weight	0.1	0.7	2.2	1.0	0.9	0.6	-0.7	-1.0	-0.4	-1.5	-0.1	-0.3	1.3	0.5	0.6	0.9
Right kidney weight	0.6	2.6	3.3	1.8	1.7	1.7	-1.8	-1.7	-1.6	-1.8	-1.4	-1.7	1.7	1.4	1.6	-0.5
Cocaine induced anxiety	0.5	0.7	0.9	-0.8	-0.8	-0.8	0.7	0.9	0.7	1.0	0.7	0.8	-1.0	-0.8	-0.9	0.8
Post-drug Anxiety	0.6	0.6	0.9	-0.8	-0.8	-0.7	0.7	0.9	0.7	0.9	0.6	0.8	-0.9	-0.8	-0.9	0.7
Baseline Anxiety	0.0	0.0	0.1	0.0	-0.0	0.1	-0.0	0.0	-0.1	0.1	-0.1	-0.3	-0.1	-0.0	0.1	-0.1
Tail length	0.0	0.1	0.2	-0.2	-0.1	-0.2	0.2	0.2	0.3	0.1	0.2	0.1	-0.3	-0.5	-0.3	0.4
Length with tail	0.2	0.9	2.3	-0.8	-0.8	-1.0	0.9	0.8	1.0	0.5	1.1	0.7	-0.7	-1.1	-0.9	1.5
Length without tail	0.1	0.2	0.7	-0.3	-0.3	-0.6	0.3	0.3	0.4	0.2	0.6	-0.2	-0.2	-0.5	-0.3	0.9
Times rat made contact with spout	1.2	1.4	1.6	-1.2	-1.2	-1.2	1.2	1.2	1.2	1.2	1.1	1.1	-1.2	-1.2	-1.2	0.8
Lifetime Intake	2.3	2.8	4.5	-2.0	-1.9	-1.7	1.7	1.9	1.5	2.1	1.3	1.5	-2.0	-1.6	-1.5	0.5
Liver weight, left	2.1	3.5	4.4	-2.1	-2.0	-1.9	1.8	2.1	1.8	2.0	1.8	1.7	-1.9	-1.8	-1.8	1.7
Liver weight, right	0.2	0.3	1.6	-0.2	-0.3	-0.4	0.4	0.2	0.5	-0.0	0.6	1.3	-0.0	-0.3	-0.4	0.9
Locomotor activity	1.8	2.9	4.8	-1.6	-1.5	-1.9	1.7	1.4	2.0	0.9	2.2	2.1	-1.0	-1.7	-1.2	2.1
Locomotor testing distance	1.3	2.4	3.7	-1.6	-1.5	-1.7	1.6	1.4	1.7	1.0	1.9	1.6	-1.1	-1.6	-1.2	1.9
Locomotor testing rearing	0.1	0.2	0.4	-0.3	-0.2	-0.5	0.4	0.0	0.5	-0.2	0.7	0.7	0.1	-0.3	-0.1	0.6
Locomotion in novel chamber	0.5	0.6	1.6	-0.8	-0.8	-0.5	0.6	1.0	0.4	1.3	0.2	0.4	-1.2	-0.7	-0.8	-0.0
Locomotion in novel chamber post-restriction	0.1	0.2	0.5	0.6	0.5	0.3	-0.5	-0.5	-0.3	-0.7	-0.2	0.1	0.7	0.5	0.5	0.2
Fecal boli incidents, locomotor time 1	1.0	1.5	1.7	-1.2	-1.2	-1.2	1.3	1.2	1.3	1.1	1.2	1.2	-1.2	-1.3	-1.2	1.0
Change in fecal boli incidents, locomotor task	0.3	0.3	1.2	0.5	0.4	0.5	-0.5	-0.4	-0.6	-0.2	-0.7	-0.7	0.3	0.6	0.5	-1.1
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.0	-0.0	-0.1	0.2	-0.1	0.2	-0.2	0.3	0.1	0.1	-0.0	-0.2	0.3
Bouts of movement, locomotor time 1	0.2	0.2	0.6	0.3	0.2	-0.0	-0.0	-0.4	0.2	-0.7	0.5	0.7	0.6	0.0	0.0	0.8
Total resting periods, locomotor time 1	0.1	0.1	0.6	0.3	0.0	-0.2	0.1	-0.2	0.3	-0.4	0.5	0.8	0.3	-0.2	-0.2	0.7
Rest time, locomotor task time 1	0.8	1.0	1.3	-1.0	-1.1	-1.1	1.1	1.1	1.0	1.1	0.9	0.9	-1.1	-1.0	-0.9	0.5
Distance moved, locomotor task time 1	0.7	1.0	1.5	0.9	1.0	1.1	-1.2	-0.8	-1.2	-0.7	-1.2	-1.2	0.8	1.1	1.0	-0.6
Vertical activity count, locomotor time 1	0.5	1.1	1.6	1.1	1.1	1.1	-1.3	-0.9	-1.2	-0.8	-1.2	-1.1	0.9	1.1	1.0	-0.4
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	-0.4	-0.5	-0.4	0.5	0.5	0.4	0.5	0.4	0.1	-0.6	-0.5	-0.6	0.4
Bouts of movement, locomotor time 2	0.2	0.2	0.5	0.7	0.6	0.5	-0.5	-0.7	-0.4	-0.7	-0.4	-0.0	0.6	0.4	0.3	-0.2
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.5	0.4	0.4	-0.3	-0.5	-0.2	-0.6	-0.2	0.1	0.5	0.2	0.2	-0.1
Rest time, locomotor task time 2	0.0	0.1	0.2	0.1	0.2	0.2	-0.1	-0.4	-0.1	-0.4	-0.1	-0.2	0.3	0.1	0.1	-0.3
Distance moved, locomotor task time 2	0.1	0.1	0.4	-0.4	-0.3	-0.2	-0.0	0.6	0.0	0.6	0.0	-0.3	-0.4	0.0	0.1	0.3
Vertical activity count, locomotor time 2	0.7	1.0	2.6	-1.0	-1.1	-0.9	0.8	1.4	0.7	1.6	0.5	0.4	-1.5	-0.8	-1.0	0.6
Light reinforcement 1	0.2	0.5	1.4	-0.4	-0.5	-0.7	0.7	0.2	0.9	-0.2	1.1	0.8	0.0	-0.5	-0.5	1.2
Light reinforcement 2	0.1	0.1	0.2	-0.2	-0.3	-0.4	0.3	0.4	0.3	0.3	0.3	0.3	-0.3	-0.3	-0.4	0.3
Bone: marrow area	0.3	0.7	2.6	-0.7	-0.8	-0.7	0.8	0.6	0.9	0.3	1.1	0.9	-0.4	-0.7	-0.9	1.6
Bone: maximum diameter	0.1	0.1	0.8	0.0	0.1	0.0	0.0	-0.2	0.2	-0.5	0.4	0.6	0.4	0.0	-0.0	0.9
Bone: maximum force	0.5	0.9	3.3	-0.6	-0.7	-0.8	0.9	0.4	1.1	-0.0	1.4	1.3	-0.1	-0.8	-0.8	1.8
Bone: maximum moment	0.4	0.7	2.8	-0.4	-0.5	-0.5	0.7	0.1	0.9	-0.3	1.2	1.1	0.1	-0.6	-0.6	1.7
Mean time between licks in bursts	0.5	1.2	3.2	-0.8	-0.9	-1.1	1.1	0.7	1.3	0.3	1.5	1.0	-0.6	-1.1	-1.3	1.8
Mean num. licks in bursts	1.4	2.1	3.1	-1.4	-1.4	-1.6	1.6	1.3	1.7	0.9	1.8	1.4	-1.1	-1.5	-1.4	1.7
Cd content in liver	3.6	4.0	5.2	-2.1	-2.2	-2.0	2.1	2.1	1.9	2.2	1.7	1.6	-2.3	-2.0	-2.2	1.2
Co content in liver	0.3	0.4	1.0	-0.7	-0.7	-0.5	0.5	0.8	0.4	1.0	0.2	0.1	-0.9	-0.6	-0.6	-0.2
Cu content in liver	0.2	0.3	0.4	-0.6	-0.5	-0.6	0.6	0.5	0.6	0.5	0.5	0.6	-0.5	-0.5	-0.4	0.3
Fe content in liver	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.6	0.4	0.5	0.5	0.4	0.6	-0.5	-0.5	-0.5	0.0
K content in liver	1.4	1.3	3.4	1.4	1.3	1.1	-1.0	-1.5	-0.8	-1.8	-0.5	-0.4	1.6	0.9	1.0	0.1
Mg content in liver	1.0	1.0	3.2	1.2	1.1	0.8	-0.8	-1.3	-0.5	-1.8	-0.2	-0.4	1.6	0.7	0.9	0.4
Mn content in liver	0.3	0.3	1.0	0.6	0.6	0.5	-0.4	-0.8	-0.3	-1.0	-0.2	0.2	0.8	0.2	0.4	0.1
Na content in liver	0.5	0.6	0.8	0.7	0.8	0.8	-0.9	-0.7	-0.9	-0.6	-0.8	-0.6	0.7	0.7	0.9	-0.7
Rb content in liver	0.9	1.0	1.3	1.0	1.0	0.9	-0.9	-1.2	-0.9	-1.1	-0.8	-1.1	1.1	1.0	1.1	-1.1
Se content in liver	0.7	0.9	1.4	-0.9	-0.9	-1.0	1.0	0.9	1.0	0.8	0.9	1.2	-0.9	-1.0	-0.9	0.7
Sr content in liver	0.2	0.1	0.6	-0.2	-0.1	0.1	-0.1	0.3	-0.2	0.6	-0.4	-0.5	-0.4	0.1	-0.1	-0.8
Zn content in liver	0.1	0.1	0.3	-0.1	-0.2	-0.3	0.3	0.2	0.3	0.1	0.4	0.2	-0.2	-0.3	-0.4	0.6
Bone: minimum diameter	0.7	1.3	5.8	-0.6	-0.7	-0.9	0.9	0.3	1.3	-0.3	1.7	1.5	0.0	-0.8	-1.0	2.4
Time in familiar zone, hab. session 1	0.2	0.2	0.7	-0.5	-0.4	-0.5	0.3	0.7	0.2	0.8	0.1	0.2	-0.6	-0.3	-0.1	-0.3
Time in novel zone, hab. session 1	2.5	2.5	3.4	1.7	1.7	1.7	-1.5	-1.8	-1.5	-1.8	-1.4	-1.4	1.7	1.5	1.4	-1.1
Total zone transitions, hab. session 1	0.3	0.5	1.2	0.7	0.7	0.8	-0.8	-0.5	-0.8	-0.5	-0.7	-1.1	0.6	0.5	0.7	-0.2
Total locomotion distance, hab. session 1	2.5	3.5	4.1	1.9	1.9	2.0	-2.0	-1.9	-1.9	-1.9	-1.8	-2.0	2.0	1.8	1.9	-1.2
Locomotion velocity, hab. session 1	2.2	3.1	3.8	1.8	1.8	1.9	-1.9	-1.8	-1.8	-1.8	-1.6	-1.9	1.8	1.6	1.8	-1.1
Time in familiar zone, hab. session 2	0.1	0.1	0.4	-0.2	-0.1	-0.2	0.2	0.1	0.2	-0.0	0.3	0.6	0.1	-0.0	-0.1	0.3
Time in novel zone, hab. session 2	1.4	1.4	2.5	1.3	1.1	1.2	-1.1	-1.2	-1.2	-1.1	-1.2	-1.6	1.1	1.1	1.1	-1.2
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.3	-0.3	-0.1	0.2	0.4	0.1	0.5	0.1	0.0	-0.4	-0.3	-0.3	0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.3	0.3	0.3	0.4	-0.4	-0.3	-0.4	-0.2	-0.4	-0.5	0.3	0.3	0.4	-0.3
Locomotion velocity, hab. session 2	0.0	0.0	0.0	-0.0	0.1	0.2	-0.1	0.0	-0.2	0.1	-0.2	-0.2	-0.0	0.0	0.1	-0.1
Novel to familiar place preference ratio	8.7	9.5	10.8	3.3	3.2	3.0	-3.1	-3.1	-3.1	-3.0	-3.0	-3.2	3.0	3.1	3.1	-2.8
Novelty place preference	11.0	11.8	13.2	3.6	3.6	3.4	-3.5	-3.5	-3.4	-3.3	-3.4	-3.5	3.4	3.4	3.5	-3.1
Time in novel zone, NPP test	12.2	13.1	14.5	3.8	3.7	3.6	-3.7	-3.7	-3.6	-3.5	-3.5	-3.6	3.6	3.6	3.7	-3.3
Total zone transitions, NPP test	1.5	2.2	3.2	-1.8	-1.6	-1.3	1.3	1.7	1.2	1.8	1.2	1.2	-1.7	-1.5	-1.3	1.2
Total locomotion distance, NPP test	0.5	0.6	1.0	-0.9	-0.8	-0.7	0.7	1.0	0.6	1.0	0.6	0.7	-0.9	-0.8	-0.7	0.7
Locomotion velocity, NPP test	0.8	1.1	1.5	-1.2	-1.1	-0.9	0.9	1.2	0.9	1.2	0.9	1.0	-1.1	-1.1	-1.0	1.0
Intraocular pressure	0.7	1.0	1.4	-1.2	-1.0	-1.0	1.1	0.9	1.1	0.8	1.2	0.9	-0.8	-0.8	-0.9	0.7
Delta distance traveled before/after self-admin	0.9	1.0	1.3	-1.1	-1.1	-1.0	1.1	1.0	1.0	1.1	0.9	0.8	-1.1	-1.0	-1.0	0.6
Delta ambulatory time before/after self-admin	0.3	0.4	0.6	-0.8	-0.7	-0.6	0.7	0.6	0.6	0.7	0.5	0.5	-0.7	-0.6	-0.5	0.1
Parametrial fat weight	0.4	0.9	1.5	-1.0	-1.0	-1.0	0.9	1.0	0.9	0.9	1.0	0.7	-0.9	-0.8	-0.9	1.2
Pavlov. Cond. lever latency	1.7	2.1	3.0	1.6	1.5	1.4	-1.4	-1.7	-1.4	-1.7	-1.3	-1.2	1.6	1.4	1.4	-1.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.0	0.3	-0.0	0.3	-0.0	-0.2	-0.1	0.0	0.0	0.1
Pavlov. Cond. change in total contacts	0.6	0.6	1.2	-0.9	-0.8	-0.7	0.6	1.1	0.6	1.1	0.5	0.6	-1.0	-0.7	-0.7	0.6
Pavlov. Cond. index score	0.6	0.8	2.0	-1.1	-0.9	-0.8	0.7	1.3	0.6	1.4	0.5	0.5	-1.2	-0.7	-0.7	0.4
Pavlov. Cond. latency score	1.2	1.5	2.6	-1.4	-1.3	-1.2	1.1	1.6	1.0	1.6	0.9	1.0	-1.4	-1.1	-1.1	0.9
Pavlov. Cond. lever contacts	1.8	2.2	2.9	-1.6	-1.5	-1.4	1.4	1.7	1.4	1.6	1.4	1.3	-1.5	-1.4	-1.4	1.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	0.1	-0.1	-0.2	0.3	-0.3	0.4	-0.5	0.5	0.5	0.2	-0.4	-0.3	0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.8	-0.2	-0.4	-0.4	0.5	0.3	0.5	0.2	0.5	0.4	-0.4	-0.6	-0.7	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.4	-0.9	-0.8	-0.7	0.5	1.1	0.5	1.2	0.4	0.4	-1.0	-0.5	-0.5	0.3
Pavlov. Cond. response bias	0.1	0.1	0.6	-0.4	-0.3	-0.1	-0.0	0.6	-0.1	0.8	-0.1	-0.3	-0.5	-0.0	0.0	-0.3
Pavlov. Cond. lever latency	0.1	0.1	0.4	-0.4	-0.3	-0.6	0.4	0.3	0.5	0.2	0.5	0.5	-0.1	-0.2	-0.0	0.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.1	0.0	0.3	-0.2	0.2	-0.3	0.3	-0.4	-0.2	-0.3	0.0	-0.1	-0.3
Pavlov. Cond. change in total contacts	0.6	1.0	1.5	-1.0	-1.1	-0.7	0.9	1.1	0.9	1.2	0.8	0.5	-1.2	-1.1	-1.2	1.0
Pavlov. Cond. index score	0.1	0.1	0.2	-0.1	-0.1	0.2	-0.0	0.3	-0.1	0.5	-0.2	-0.3	-0.4	-0.1	-0.3	-0.0
Pavlov. Cond. latency score	0.1	0.1	0.4	-0.2	-0.3	0.1	0.1	0.4	-0.0	0.6	-0.2	-0.2	-0.6	-0.2	-0.4	0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.5	0.6	0.4	0.7	-0.5	-0.4	-0.6	-0.3	-0.6	-0.5	0.3	0.4	0.2	-0.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	-0.3	-0.3	-0.6	0.5	0.1	0.6	-0.1	0.7	0.7	0.0	-0.3	-0.2	0.6
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.4	-0.2	-0.2	-0.3	0.2	0.1	0.3	-0.1	0.4	0.3	0.1	-0.1	-0.1	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.1	-0.2	0.2	0.0	0.4	-0.1	0.6	-0.2	-0.3	-0.5	-0.2	-0.4	0.0
Pavlov. Cond. response bias	0.1	0.1	0.3	0.3	0.2	0.6	-0.3	-0.2	-0.4	-0.1	-0.4	-0.4	0.1	0.2	0.0	-0.1
Time in closed arm before self-admin	0.4	0.5	0.7	0.8	0.7	0.8	-0.7	-0.8	-0.7	-0.8	-0.7	-0.3	0.7	0.6	0.6	-0.5
Time in closed arm after self-admin	0.7	0.7	1.6	1.0	1.0	0.8	-0.8	-1.1	-0.7	-1.3	-0.5	-0.3	1.2	0.8	0.8	-0.2
Time in open arm before self-admin	0.4	0.4	1.0	0.3	0.6	0.4	-0.7	-0.4	-0.6	-0.4	-0.6	-0.7	0.6	0.9	1.0	-1.0
Time in open arm after self-admin	0.1	0.1	0.5	-0.0	0.0	0.0	-0.1	0.1	-0.2	0.3	-0.3	-0.7	-0.2	0.1	0.1	-0.5
Bone: periosteal estimation	0.3	0.6	3.3	-0.4	-0.4	-0.5	0.6	0.1	0.8	-0.3	1.2	1.1	0.2	-0.5	-0.6	1.8
Bone: periosteal perimeter	0.3	0.5	2.0	-0.3	-0.3	-0.5	0.5	0.1	0.7	-0.3	1.0	1.1	0.1	-0.4	-0.6	1.4
Bone: post-yield work	1.5	2.2	3.2	-1.5	-1.6	-1.5	1.5	1.7	1.4	1.8	1.2	1.1	-1.8	-1.5	-1.5	0.9
Progressive ratio test 1 active lever presses	2.6	3.2	4.1	-2.0	-2.0	-1.9	1.9	1.8	1.8	1.8	1.8	1.8	-1.8	-1.8	-1.6	1.3
Progressive ratio test 1 breakpoint	2.9	3.5	4.4	-2.1	-2.0	-2.0	1.9	1.9	1.9	1.9	1.9	1.9	-1.8	-1.8	-1.7	1.4
Progressive ratio test 1 inactive lever presses	1.4	2.0	2.5	-1.6	-1.6	-1.5	1.5	1.5	1.3	1.6	1.2	1.5	-1.5	-1.3	-1.3	0.6
Progressive ratio test 2 active lever presses	1.1	1.2	3.8	-1.5	-1.3	-1.0	0.9	1.4	0.5	1.9	0.3	0.3	-1.6	-0.8	-0.6	-0.7
Progressive ratio test 2 breakpoint	0.9	1.0	3.3	-1.3	-1.1	-0.9	0.8	1.3	0.4	1.8	0.2	0.2	-1.5	-0.7	-0.5	-0.8
Progressive ratio test 2 inactive lever presses	0.2	0.4	1.2	-0.8	-0.7	-0.6	0.5	0.8	0.3	1.1	0.2	0.2	-0.9	-0.4	-0.5	-0.3
Incentive Sensitization - Responses	0.3	0.4	1.5	-0.9	-0.7	-0.5	0.4	0.9	0.1	1.2	-0.0	-0.1	-1.0	-0.3	-0.2	-0.7
Incentive Sensitization - Breakpoint	0.3	0.4	1.6	-0.9	-0.7	-0.5	0.4	0.9	0.1	1.3	-0.1	-0.1	-1.0	-0.3	-0.1	-0.8
Sum of active levers in priming session hrs 5-6	2.2	2.1	2.6	-1.6	-1.6	-1.5	1.6	1.5	1.5	1.5	1.4	1.0	-1.5	-1.5	-1.4	0.9
Progressive ratio	0.1	0.2	0.2	0.4	0.4	0.3	-0.4	-0.5	-0.4	-0.5	-0.3	-0.3	0.5	0.5	0.2	-0.4
Food seeking constrained by brief footshock	0.6	0.7	1.5	0.8	0.9	0.6	-0.8	-1.0	-0.7	-1.2	-0.5	-0.5	1.2	1.1	0.9	-0.6
Seeking ratio, punishment vs. effort	0.4	0.6	0.9	0.7	0.8	0.7	-0.8	-0.7	-0.8	-0.7	-0.8	-0.7	0.7	0.8	0.9	-0.8
Retroperitoneal fat weight	0.1	0.3	0.6	-0.5	-0.6	-0.7	0.4	0.6	0.5	0.5	0.6	0.1	-0.4	-0.3	-0.2	0.6
Reaction time number correct	2.4	4.6	6.9	-2.4	-2.3	-2.3	2.2	2.4	2.0	2.6	1.8	2.2	-2.5	-2.0	-1.8	0.8
Reaction time mean minus median	0.0	0.1	0.4	-0.2	-0.2	-0.2	0.2	0.4	0.2	0.4	0.0	-0.6	-0.4	-0.4	-0.2	-0.1
Reaction time mean minus median AUC	0.1	0.2	0.9	0.2	0.2	0.3	-0.3	-0.0	-0.4	0.2	-0.5	-0.9	-0.1	0.1	0.3	-0.7
Reaction time num false alarms	0.0	0.0	0.1	0.0	0.1	0.1	-0.1	-0.2	-0.1	-0.2	-0.1	-0.3	0.2	0.1	0.2	-0.1
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.3	-0.2	-0.1	0.2	0.2	0.1	0.2	0.1	-0.0	-0.2	-0.2	-0.1	0.0
Reaction time trials correct on left	2.4	4.6	6.9	-2.4	-2.3	-2.3	2.2	2.4	2.0	2.6	1.8	2.2	-2.5	-2.0	-1.8	0.8
Reaction time trials on left	2.5	4.8	7.0	-2.4	-2.4	-2.3	2.2	2.5	2.0	2.6	1.8	2.2	-2.5	-2.0	-1.8	0.9
Reaction time mean	1.5	2.4	3.0	-1.5	-1.6	-1.7	1.7	1.6	1.6	1.5	1.5	0.7	-1.6	-1.7	-1.7	1.3
Reaction time mean AUC	1.1	1.8	2.3	-1.3	-1.4	-1.5	1.5	1.4	1.4	1.3	1.3	0.6	-1.4	-1.4	-1.5	1.1
Median of all reaction times	1.7	2.3	3.1	-1.5	-1.6	-1.7	1.7	1.5	1.6	1.5	1.5	0.9	-1.6	-1.6	-1.7	1.3
Reaction time omissions	0.9	1.4	4.0	-0.8	-0.9	-1.2	1.2	0.8	1.4	0.3	1.6	0.6	-0.6	-1.3	-1.2	2.0
Reaction time false alarm rate	0.9	1.2	1.7	1.1	1.2	1.2	-1.1	-1.2	-1.0	-1.2	-1.0	-1.3	1.2	0.9	1.0	-0.6
Reaction time premature initiation rate	0.7	1.0	1.4	1.2	1.1	1.0	-1.0	-1.1	-1.0	-1.1	-0.9	-0.5	1.1	1.0	0.9	-0.7
Reaction time premature initiations	0.1	0.1	0.6	-0.3	-0.3	-0.3	0.3	0.3	0.2	0.4	0.1	0.8	-0.4	-0.2	-0.2	-0.2
Std. dev. reaction times	0.2	0.3	0.5	-0.5	-0.5	-0.5	0.5	0.7	0.5	0.7	0.3	-0.5	-0.7	-0.6	-0.6	0.3
Reaction time trials completed	2.5	4.8	7.0	-2.4	-2.4	-2.3	2.2	2.5	2.0	2.6	1.8	2.2	-2.5	-2.0	-1.8	0.9
Reaction time trials AUC	2.4	4.5	6.3	-2.3	-2.3	-2.3	2.2	2.4	2.0	2.5	1.8	2.2	-2.4	-2.0	-1.8	1.0
Run reversals in cocaine runway, females	0.2	0.2	1.0	0.3	0.2	0.5	-0.3	-0.2	-0.5	0.1	-0.6	-0.2	0.0	0.4	0.3	-1.0
Run reversals in cocaine runway, males	0.5	0.5	0.8	-0.8	-0.8	-0.6	0.6	0.9	0.6	0.9	0.5	0.3	-0.8	-0.7	-0.7	0.6
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.2	-0.3	-0.3	0.3	0.3	0.4	0.3	0.3	0.5	-0.3	-0.4	-0.3	0.3
Latency to leave start box in cocaine runway, F	0.0	0.0	0.3	-0.0	-0.1	-0.2	0.1	0.2	0.2	0.1	0.2	0.5	-0.1	-0.2	-0.1	0.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.2	-0.2	-0.2	0.3	0.2	0.3	0.1	0.3	0.1	-0.2	-0.3	-0.3	0.3
Std. dev. time between licks in bursts	0.4	0.5	2.6	-0.2	-0.5	-0.5	0.6	0.4	0.7	0.2	0.8	0.5	-0.4	-0.6	-1.0	1.6
Total sessions with >9 infusions	3.8	4.6	6.2	-2.3	-2.2	-2.3	2.3	2.1	2.2	2.0	2.2	2.5	-2.0	-2.0	-2.0	1.5
Short access day 1 total inactive lever presses	1.0	1.3	2.6	0.8	1.0	1.1	-1.1	-0.9	-1.2	-0.6	-1.3	-1.3	0.9	1.3	1.2	-1.6
Short access day 10 total inactive lever presses	1.8	4.4	5.0	2.2	2.2	2.2	-2.2	-2.1	-2.1	-2.0	-2.0	-2.2	2.1	2.2	2.1	-1.6
Short access day 1 total infusions	1.1	1.4	1.7	-1.3	-1.3	-1.2	1.3	1.2	1.2	1.3	1.1	1.1	-1.2	-1.1	-1.2	0.7
Short access day 10 total infusions	3.5	4.4	5.4	-2.3	-2.3	-2.2	2.2	2.2	2.1	2.2	2.0	2.2	-2.2	-2.1	-2.0	1.4
Short access total infusions	3.8	4.8	5.8	-2.4	-2.3	-2.3	2.3	2.3	2.2	2.3	2.1	2.3	-2.2	-2.1	-2.1	1.4
Short access day 1 locomotion	0.1	0.1	0.3	-0.4	-0.4	-0.3	0.3	0.3	0.1	0.5	0.0	0.2	-0.4	-0.1	-0.1	-0.5
Short access day 10 total locomotion	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0	-0.0	0.0	-0.1	0.1	0.1	0.1	-0.0	-0.0	0.2
Short access total locomotion	1.4	1.7	2.4	-1.5	-1.4	-1.4	1.4	1.3	1.3	1.4	1.3	1.5	-1.3	-1.2	-1.2	0.6
One hour access (0.3 mA shock)	0.4	0.5	1.5	-0.9	-0.8	-0.6	0.6	0.9	0.4	1.2	0.2	0.4	-1.1	-0.6	-0.5	-0.1
Compulsive drug intake	0.3	0.4	1.0	-0.4	-0.6	-0.4	0.6	0.5	0.6	0.4	0.7	0.7	-0.5	-0.7	-0.8	1.0
One hour access (shock baseline)	0.5	0.7	1.9	-1.1	-1.0	-0.9	0.7	1.1	0.5	1.4	0.3	0.5	-1.2	-0.7	-0.6	-0.3
Social response proportion	2.4	2.8	4.0	-1.5	-1.7	-1.7	1.8	1.5	1.8	1.3	1.8	1.5	-1.5	-1.7	-2.0	1.7
Social responses	0.0	0.0	0.1	0.2	0.1	0.3	-0.1	-0.2	-0.2	-0.1	-0.2	-0.4	0.1	0.1	-0.1	-0.2
Social time	2.5	3.4	5.0	-1.8	-1.7	-2.1	2.0	1.5	2.2	1.2	2.2	2.0	-1.3	-1.8	-1.7	1.8
Soleus weight	11.0	32.4	36.1	6.0	6.0	5.8	-5.9	-5.9	-5.6	-5.9	-5.3	-5.2	6.0	5.9	5.9	-4.3
Bone: stiffness	0.2	0.3	1.2	-0.3	-0.3	-0.4	0.5	0.1	0.6	-0.1	0.8	0.9	-0.0	-0.4	-0.4	1.1
Tibialis anterior weight	0.2	0.5	1.2	0.5	0.6	0.8	-0.8	-0.5	-0.9	-0.3	-0.8	-1.1	0.5	0.8	0.8	-0.7
Time to tail flick, vehicle, before self-admin	1.9	1.9	2.4	-1.2	-1.3	-1.5	1.5	1.3	1.5	1.1	1.5	1.5	-1.3	-1.4	-1.5	1.4
Time to tail flick, vehicle, after self-admin	1.5	2.0	3.2	-1.5	-1.5	-1.4	1.5	1.6	1.3	1.8	1.0	1.0	-1.8	-1.4	-1.5	0.6
Time to tail flick, test, before self-admin	2.3	2.4	4.4	1.6	1.6	1.5	-1.4	-1.7	-1.4	-1.6	-1.4	-2.1	1.6	1.4	1.4	-1.4
Time to tail flick, test, after self-admin	4.2	4.4	5.2	2.0	2.1	2.1	-2.1	-2.1	-2.1	-1.9	-2.1	-1.9	2.0	2.2	2.2	-2.3
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.8	-0.7	-0.7	-0.6	0.6	0.8	0.5	0.9	0.4	0.5	-0.9	-0.6	-0.7	0.3
Delta time to tail flick, test, before/after SA	1.1	1.1	1.8	0.9	1.0	1.1	-1.2	-0.9	-1.2	-0.7	-1.3	-0.6	0.9	1.3	1.2	-1.3
Tibia length	3.4	9.4	13.3	-2.9	-2.9	-3.1	3.1	2.8	3.2	2.3	3.4	3.7	-2.5	-3.2	-3.0	3.6
Ambulatory time before self-admin	0.6	0.8	1.4	1.0	0.9	1.0	-1.0	-0.8	-1.0	-0.8	-1.0	-1.2	0.8	0.9	0.8	-0.7
Ambulatory time after self-admin	0.0	0.0	0.4	0.2	0.0	0.3	-0.1	-0.1	-0.2	0.0	-0.2	-0.6	-0.0	-0.0	-0.0	-0.1
Bone: tissue strength	0.6	0.6	3.4	0.2	0.1	-0.2	0.3	-0.5	0.7	-1.2	1.1	0.8	0.8	-0.3	-0.3	1.8
Total heroin consumption	5.2	6.1	8.7	2.2	2.4	2.4	-2.5	-2.4	-2.5	-2.1	-2.5	-2.3	2.4	2.7	2.7	-2.9
Bone: trabecular number	6.6	10.8	13.0	3.2	3.2	3.5	-3.4	-3.1	-3.6	-2.6	-3.6	-3.3	2.8	3.4	3.4	-3.6
Bone: trabecular spacing	4.2	5.5	7.5	-2.1	-2.2	-2.4	2.5	2.1	2.6	1.6	2.7	2.6	-1.9	-2.5	-2.4	2.7
Bone: trabecular thickness	0.4	0.6	0.7	0.8	0.8	0.7	-0.8	-0.9	-0.7	-0.9	-0.7	-0.4	0.8	0.8	0.7	-0.6
Bone: trabecular tissue density	0.6	0.8	1.8	-0.7	-0.7	-0.9	0.9	0.7	1.0	0.5	1.0	1.2	-0.6	-0.9	-1.0	1.3
Water consumed over 24 hours	0.0	0.0	0.1	-0.3	-0.3	-0.2	0.2	0.2	0.2	0.2	0.2	0.2	-0.2	-0.2	-0.2	0.2
Number of responses in last shaping day	0.1	0.1	0.9	0.0	0.1	0.2	-0.2	-0.0	-0.4	0.3	-0.5	-0.3	-0.1	0.4	0.3	-1.0