Hub : Genes

Pik3ca

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Pik3ca 0.03 0.02 2.5e-04 0.03 0.03 0.03 0.03 3.3e-04 2.6e-04 3.2e-04 2.7e-04
2 PL mRNA stability Pik3ca 0.05 0.03 3.4e-07 0.06 0.05 0.05 0.06 4.5e-07 5.8e-06 2.0e-06 7.7e-07
3 Liver mRNA stability Pik3ca 0.14 0.08 1.0e-13 0.1 0.1 0.09 0.09 2.1e-11 1.3e-11 5.6e-10 3.3e-10
4 LHb mRNA stability Pik3ca 0.16 0.11 8.5e-04 0.08 0.19 0.08 0.08 5.4e-03 2.9e-05 6.3e-03 7.3e-03
5 Brain mRNA stability Pik3ca 0.16 0.08 5.6e-17 0.15 0.16 0.16 0.16 1.0e-13 4.4e-15 2.1e-14 1.4e-14
6 IL mRNA stability Pik3ca 0.29 0.15 1.8e-05 0.1 0.22 0.16 0.22 2.6e-03 5.3e-06 1.3e-04 3.9e-06
7 pVTA mRNA stability Pik3ca 0.06 0.05 5.0e-03 0.1 0.04 0.05 0.06 6.2e-05 7.8e-03 2.3e-03 1.6e-03
8 RMTg mRNA stability Pik3ca 0.51 0.16 1.7e-06 0.15 0.23 0.14 0.17 6.6e-05 8.8e-07 1.5e-04 2.3e-05
9 Adipose mRNA stability Pik3ca 0.07 0.05 6.2e-08 0.05 0.05 0.03 0.05 1.2e-06 1.6e-06 3.6e-04 2.0e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density3.55.86.4-2.52.5-2.5-2.5-2.4-2.52.4-1.82.5
Area under the delay curve1.21.31.6-1.11.1-1.0-1.2-1.3-1.01.2-1.21.2
BMI with tail0.61.82.4-1.21.4-1.2-1.5-1.5-1.21.5-1.21.4
BMI without tail1.22.43.0-1.51.6-1.4-1.7-1.7-1.31.6-1.51.5
Body weight0.00.10.30.3-0.10.4-0.1-0.00.1-0.10.6-0.0
Weight adjusted by age1.41.62.21.0-1.20.81.41.50.9-1.51.3-1.5
Bone surface0.20.30.7-0.60.5-0.7-0.6-0.3-0.90.40.60.5
Bone volume0.40.71.5-0.90.7-1.1-0.9-0.5-1.20.70.40.8
Breakpoint value in progressive ratio session2.73.05.2-1.61.8-1.5-1.6-1.9-1.21.8-2.31.8
Number of licking bursts1.11.23.0-0.91.2-0.7-1.0-1.4-0.31.1-1.71.2
Context. condit. distance diff. score4.95.97.7-2.52.3-2.5-2.5-2.3-2.82.6-1.92.4
Locomotion velocity, session 11.92.13.61.8-1.51.91.41.31.6-1.10.9-1.1
Locomotion distance, session 10.60.71.51.1-0.71.20.70.61.1-0.70.7-0.7
Locomotion velocity, session 23.64.26.62.3-1.92.52.11.72.6-1.91.1-1.9
Locomotion distance, session 21.31.82.41.5-1.21.61.31.21.5-1.31.2-1.2
Locomotion velocity, session 30.00.00.10.2-0.10.20.10.10.1-0.10.4-0.2
Locomotion distance, session 30.30.40.80.7-0.50.70.70.50.9-0.60.2-0.5
Stereotopy head waving bouts, day 30.00.00.10.2-0.30.20.30.20.2-0.2-0.20.1
Stereotopy head waving duration, day 30.70.81.0-0.90.9-0.9-0.9-0.9-0.90.9-1.01.0
Locomotion velocity, session 70.91.02.90.8-0.80.80.81.00.7-1.01.7-1.1
Locomotion distance, session 70.60.81.40.8-0.90.70.91.00.7-0.91.2-0.9
Stereotopy head waving bouts, day 71.11.22.3-0.91.2-0.7-1.1-1.4-0.61.1-1.51.2
Stereotopy head waving duration, day 71.11.42.0-1.01.3-0.8-1.2-1.4-0.71.1-1.41.2
Locomotion velocity, session 81.82.13.1-1.31.5-1.2-1.5-1.6-1.11.4-1.51.8
Locomotion distance, session 80.81.22.2-1.11.0-1.1-1.2-1.0-1.51.3-0.51.2
Degree of sensitization distance0.60.61.50.6-0.90.50.81.00.3-0.71.2-0.8
Degree of sensitization stereotypy1.61.72.6-1.21.5-1.0-1.3-1.6-0.81.3-1.61.3
Conditioned locomotion0.10.10.7-0.40.2-0.5-0.2-0.1-0.80.3-0.0-0.0
Cocaine response after cond. corrected0.00.00.1-0.1-0.1-0.10.00.1-0.30.10.00.1
Cocaine response after cond. not corrected0.30.30.60.5-0.70.40.50.70.3-0.40.8-0.4
Cocaine response before conditioning0.10.10.50.2-0.10.20.10.30.1-0.10.7-0.2
Saline control response0.50.61.40.7-0.90.60.71.00.1-0.71.2-0.7
Bone: connectivity density1.92.93.2-1.71.8-1.7-1.8-1.7-1.61.7-1.61.8
Bone: cortical apparent density0.00.10.1-0.20.1-0.3-0.1-0.1-0.20.3-0.40.4
Bone: cortical area0.20.30.9-0.50.1-0.7-0.30.2-0.90.20.80.3
Bone: cortical porosity0.00.00.1-0.30.1-0.3-0.1-0.1-0.30.1-0.30.2
Bone: cortical porosity0.10.10.3-0.40.2-0.5-0.3-0.1-0.60.20.10.3
Bone: cortical thickness0.40.61.7-0.90.5-1.0-0.7-0.3-1.30.70.20.9
Bone: cortical thickness0.30.30.70.8-0.60.80.60.40.8-0.4-0.1-0.4
Bone: cortical tissue density0.10.10.2-0.20.2-0.3-0.1-0.1-0.20.3-0.50.4
Condit. Reinf. active minus inactive responses2.02.22.41.5-1.51.51.51.51.4-1.61.5-1.5
Condit. Reinf. active-inactive response ratio1.51.62.11.2-1.31.21.31.41.0-1.31.5-1.1
Condit. Reinf. active responses1.21.51.91.2-1.11.21.11.21.2-1.31.4-1.3
Condit. Reinf. inactive responses0.00.00.10.00.3-0.0-0.2-0.10.1-0.00.2-0.2
Incentive salience index mean2.22.73.01.7-1.71.61.61.71.5-1.71.7-1.6
Condit. Reinf. lever presses0.81.01.51.1-1.01.10.91.00.8-1.01.2-1.0
Condit. Reinf. active minus inactive responses1.62.03.61.2-1.21.21.21.41.1-1.21.9-1.8
Condit. Reinf. active-inactive response ratio1.21.32.11.0-1.20.91.11.20.8-1.01.4-1.4
Condit. Reinf. active responses3.54.98.02.1-2.02.02.02.21.9-2.12.8-2.5
Condit. Reinf. inactive responses2.12.63.41.7-1.41.71.51.51.8-1.61.5-1.6
Condit. Reinf. lever presses0.40.61.80.6-0.50.60.60.70.7-0.71.3-1.0
Condit. Reinf. lever reinforcers received3.34.68.02.0-1.92.01.92.11.9-2.02.8-2.4
Conditioned reinforcement - actives0.40.40.70.7-0.80.60.80.70.7-0.5-0.2-0.5
Conditioned reinforcement - inactives0.00.00.10.2-0.20.20.20.10.2-0.1-0.0-0.1
Conditioned locomotion0.50.61.21.0-0.81.00.90.71.1-0.6-0.1-0.4
Patch foraging indifference point 0 sec0.81.32.0-1.31.4-1.2-1.1-1.4-0.70.9-1.40.9
Patch foraging indifference point AUC0.70.81.6-0.61.1-0.3-1.1-1.3-0.31.1-1.01.0
Delay disc. indifference point, 0s delay0.30.30.70.6-0.60.60.50.60.3-0.50.9-0.5
Delay disc. indifference point, 16s delay1.91.92.7-1.41.3-1.5-1.3-1.3-1.21.3-1.61.3
Delay disc. indifference point, 2s delay0.60.71.0-0.80.8-0.8-1.0-0.9-0.90.9-0.50.9
Delay disc. indifference point, 24s delay1.81.72.6-1.41.3-1.5-1.2-1.2-1.11.2-1.61.2
Delay disc. indifference point, 4s delay0.20.20.5-0.30.4-0.2-0.5-0.6-0.30.5-0.70.5
Delay disc. indifference point, 8s delay0.20.20.3-0.40.4-0.3-0.5-0.6-0.20.4-0.50.4
Indifference point function ln k0.81.11.70.7-1.20.51.11.30.4-1.11.3-1.2
Indifference point function log k0.81.11.70.7-1.20.51.11.30.4-1.11.3-1.2
Patch foraging total patch changes 0 sec0.91.52.2-1.31.5-1.2-1.2-1.5-0.70.9-1.41.0
Patch foraging total patch changes 12 sec1.01.32.2-1.11.4-0.9-1.2-1.5-0.40.9-1.30.9
Patch foraging total patch changes 18 sec0.81.11.9-0.91.3-0.7-1.1-1.4-0.40.9-1.30.9
Patch foraging total patch changes 24 sec4.45.47.1-2.32.6-2.1-2.5-2.7-1.72.2-2.32.3
Patch foraging total patch changes 6 sec3.65.47.6-2.42.8-2.2-2.4-2.8-1.42.1-2.52.1
Patch foraging time to switch 0 sec0.00.00.10.0-0.2-0.10.20.3-0.0-0.0-0.00.0
Patch foraging water rate 0 sec0.30.40.8-0.70.9-0.7-0.8-0.8-0.50.3-0.20.4
Patch foraging water rate 12 sec0.00.00.1-0.1-0.0-0.20.10.10.1-0.3-0.1-0.1
Patch foraging water rate 18 sec0.30.41.10.6-0.50.70.70.51.0-0.70.4-0.7
Patch foraging water rate 24 sec1.01.42.0-1.21.4-1.2-1.2-1.3-0.91.0-1.11.1
Patch foraging water rate 6 sec0.00.00.0-0.10.1-0.10.0-0.10.2-0.1-0.1-0.0
Seeking ratio, delayed vs. immediate footshock1.31.52.9-1.10.8-1.2-0.9-0.8-1.51.3-1.71.2
Distance traveled before self-admin1.81.92.2-1.41.4-1.3-1.5-1.5-1.41.4-1.11.4
Distance traveled after self-admin0.20.20.5-0.40.7-0.3-0.5-0.7-0.00.3-0.50.3
Extensor digitorum longus weight0.00.10.30.00.30.1-0.4-0.4-0.00.5-0.00.3
Bone: elastic displacement0.00.00.1-0.2-0.0-0.30.00.1-0.30.1-0.40.1
Bone: elastic work0.40.51.60.4-0.80.20.71.1-0.1-0.71.3-0.6
Bone: endosteal estimation0.51.23.50.9-0.90.70.81.10.6-1.11.9-1.1
Bone: endosteal perimeter0.61.32.31.1-1.11.01.01.11.0-1.21.5-1.2
Epididymis fat weight0.82.03.21.5-1.41.51.21.41.2-1.31.8-1.3
Delta time in closed arm before/after self-admin0.30.30.8-0.50.4-0.6-0.6-0.3-0.90.70.10.7
Delta time in open arm before/after self-admin0.50.51.00.6-0.50.70.70.41.0-0.80.2-0.8
Diff in mean of infusions in LGA sessions0.40.40.8-0.80.6-0.9-0.7-0.5-0.90.6-0.10.6
Delay discount exponential model param1.51.62.01.2-1.21.11.31.41.1-1.31.4-1.3
Extinction: sum of active levers before priming0.30.30.70.3-0.30.20.50.60.4-0.60.8-0.6
Active lever presses in extinction session 60.10.10.5-0.30.3-0.3-0.2-0.3-0.10.3-0.70.3
Bone: final force0.30.42.10.4-0.60.10.40.8-0.1-0.51.4-0.4
Bone: final moment0.20.31.60.1-0.3-0.10.20.6-0.3-0.31.3-0.2
Food consumed during 24 hour testing period0.00.00.10.0-0.10.0-0.00.1-0.10.00.3-0.2
Glucose1.82.83.41.6-1.71.61.71.71.5-1.81.4-1.8
Heart weight0.50.71.1-0.90.8-0.9-0.9-0.7-1.00.9-0.60.8
Delay discount hyperbolic model param1.11.11.41.0-1.01.01.11.21.0-1.11.1-1.1
Intermittent access intake day 1-15 change0.40.41.1-0.50.7-0.3-0.6-0.8-0.00.6-1.10.5
Intermittent access intake escalation0.20.20.6-0.30.6-0.2-0.5-0.70.00.4-0.80.4
Intermittent access intake escalation 20.30.30.70.5-0.20.60.40.30.8-0.60.4-0.7
Intermitt. access day 1 inactive lever presses0.00.00.10.2-0.30.10.30.30.1-0.10.0-0.2
Intermitt. access day 15 inactive lever presses0.91.02.21.1-0.91.21.10.71.5-0.9-0.0-0.8
Intermitt. access escalation Index0.00.00.00.1-0.20.00.10.1-0.10.1-0.10.1
Intermittent access day 1 total infusions3.64.24.92.2-2.22.22.22.12.0-2.01.4-1.9
Intermittent access day 15 total infusions0.60.71.41.0-0.81.10.80.51.2-0.6-0.2-0.6
Intermittent access terminal intake (last 3 days)2.62.84.11.9-1.72.01.71.52.0-1.60.8-1.6
Intermittent access total infusions2.22.43.61.8-1.61.91.71.41.9-1.40.4-1.3
Intermittent access day 1 locomotion0.80.81.11.0-1.01.01.01.00.9-0.80.5-0.7
Intermittent access day 15 total locomotion0.70.82.2-0.60.9-0.6-0.7-1.0-0.30.9-1.51.0
Intermittent access total locomotion0.30.30.80.7-0.30.70.50.10.9-0.2-0.6-0.2
Intermittent access standard deviation0.10.10.2-0.30.4-0.3-0.3-0.4-0.10.2-0.10.1
Left kidney weight0.20.50.9-0.70.6-0.7-0.8-0.5-1.00.60.40.5
Right kidney weight0.30.81.2-0.81.0-0.7-1.1-1.0-0.80.9-0.30.8
Cocaine induced anxiety0.50.61.30.9-0.70.90.80.61.2-0.70.4-0.7
Post-drug Anxiety1.82.03.11.5-1.41.61.51.21.8-1.40.5-1.4
Baseline Anxiety0.20.30.4-0.60.6-0.6-0.5-0.6-0.40.3-0.60.3
Tail length0.00.00.2-0.20.2-0.2-0.1-0.0-0.1-0.10.5-0.1
Length with tail0.31.02.80.9-0.90.80.70.90.5-1.11.7-0.9
Length without tail1.02.25.71.3-1.51.11.31.70.7-1.52.4-1.3
Times rat made contact with spout1.21.41.81.2-1.21.21.31.21.4-1.20.7-1.2
Lifetime Intake2.73.04.22.0-1.92.11.91.62.0-1.60.7-1.5
Liver weight, left1.62.54.01.9-1.72.01.61.31.8-1.50.7-1.3
Liver weight, right0.10.10.20.4-0.40.30.40.30.5-0.1-0.0-0.4
Locomotor activity1.72.74.51.7-1.91.51.62.10.7-1.42.1-1.3
Locomotor testing distance0.71.22.01.2-1.21.01.11.40.5-1.01.3-1.0
Locomotor testing rearing0.10.10.30.2-0.3-0.00.30.5-0.2-0.30.5-0.2
Locomotion in novel chamber0.40.51.40.8-0.51.00.70.41.2-0.70.1-0.7
Locomotion in novel chamber post-restriction0.20.30.8-0.50.4-0.5-0.6-0.4-0.90.50.20.5
Fecal boli incidents, locomotor time 11.31.51.81.2-1.31.11.31.31.1-1.21.0-1.3
Change in fecal boli incidents, locomotor task0.60.51.8-0.60.6-0.6-0.6-0.7-0.40.5-1.40.8
Time >=10cm from walls, locomotor time 10.00.00.10.0-0.2-0.00.10.20.1-0.10.2-0.1
Bouts of movement, locomotor time 10.10.20.6-0.1-0.1-0.3-0.10.2-0.70.20.8-0.1
Total resting periods, locomotor time 10.10.10.5-0.0-0.2-0.10.10.3-0.4-0.00.7-0.3
Rest time, locomotor task time 10.91.01.31.1-1.11.01.11.10.9-1.00.5-1.0
Distance moved, locomotor task time 10.70.81.3-0.71.0-0.6-1.1-1.1-0.51.1-0.30.8
Vertical activity count, locomotor time 10.70.81.4-0.81.0-0.6-1.2-1.2-0.61.0-0.10.8
Time >=10cm from walls, locomotor time 20.30.30.40.6-0.60.70.60.60.6-0.50.4-0.6
Bouts of movement, locomotor time 20.20.30.4-0.60.5-0.7-0.4-0.4-0.60.6-0.20.5
Total resting periods, locomotor time 20.10.10.3-0.50.3-0.5-0.3-0.2-0.40.4-0.20.4
Rest time, locomotor task time 20.10.10.2-0.40.2-0.4-0.1-0.1-0.20.1-0.40.2
Distance moved, locomotor task time 20.10.10.50.6-0.30.70.00.00.30.10.5-0.1
Vertical activity count, locomotor time 21.21.32.61.4-1.01.61.00.81.5-0.90.9-0.9
Light reinforcement 10.20.41.10.4-0.70.10.60.9-0.0-0.51.1-0.7
Light reinforcement 20.10.10.10.3-0.30.30.20.30.3-0.20.3-0.2
Bone: marrow area0.40.92.90.8-0.80.60.71.00.5-1.01.7-1.0
Bone: maximum diameter0.10.10.7-0.10.0-0.2-0.10.2-0.4-0.10.9-0.1
Bone: maximum force0.40.62.50.5-0.80.20.61.10.1-0.71.6-0.6
Bone: maximum moment0.30.52.30.3-0.60.00.50.9-0.1-0.61.5-0.5
Mean time between licks in bursts0.81.13.10.8-1.10.60.91.20.5-0.91.8-0.9
Mean num. licks in bursts1.72.02.81.3-1.61.21.41.61.0-1.51.7-1.5
Cd content in liver1.71.92.51.4-1.31.41.41.31.6-1.41.0-1.5
Co content in liver0.70.81.51.1-0.81.20.80.61.1-0.70.5-0.9
Cu content in liver0.30.40.60.6-0.80.60.70.70.4-0.60.4-0.6
Fe content in liver0.30.30.60.5-0.70.40.80.70.6-0.70.2-0.6
K content in liver1.41.42.3-1.41.2-1.4-1.3-1.0-1.51.0-0.11.2
Mg content in liver0.80.92.2-1.00.7-1.2-0.9-0.5-1.50.70.41.0
Mn content in liver0.40.41.0-0.80.5-1.0-0.5-0.3-1.00.5-0.10.6
Na content in liver1.51.61.9-1.21.3-1.1-1.3-1.4-1.21.3-1.11.4
Rb content in liver0.70.91.2-1.00.9-1.1-0.8-0.7-1.11.0-1.01.0
Se content in liver0.91.11.61.2-1.11.21.21.11.3-0.90.5-0.9
Sr content in liver0.20.21.00.20.10.30.0-0.30.60.1-1.00.1
Zn content in liver0.10.10.2-0.30.2-0.3-0.1-0.0-0.1-0.20.5-0.0
Bone: minimum diameter0.71.35.70.6-1.00.30.81.40.1-1.12.4-0.9
Time in familiar zone, hab. session 10.20.20.50.6-0.50.70.40.20.6-0.2-0.3-0.0
Time in novel zone, hab. session 12.52.43.4-1.81.7-1.9-1.6-1.4-1.71.5-1.11.3
Total zone transitions, hab. session 10.30.40.8-0.60.9-0.6-0.9-0.8-0.70.70.00.2
Total locomotion distance, hab. session 12.43.44.2-1.92.0-1.9-2.1-1.9-2.01.9-1.01.7
Locomotion velocity, hab. session 12.12.93.7-1.81.9-1.8-1.9-1.7-1.91.7-0.91.6
Time in familiar zone, hab. session 20.00.00.10.1-0.20.10.10.2-0.1-0.00.20.1
Time in novel zone, hab. session 21.31.31.5-1.21.2-1.2-1.1-1.1-1.01.1-1.11.0
Total zone transitions, hab. session 20.10.10.20.3-0.10.40.20.10.4-0.20.3-0.4
Total locomotion distance, hab. session 20.10.10.2-0.30.4-0.3-0.4-0.4-0.40.4-0.30.2
Locomotion velocity, hab. session 20.00.00.0-0.00.20.0-0.1-0.2-0.00.1-0.10.0
Novel to familiar place preference ratio9.19.410.0-3.23.0-3.1-3.1-3.1-3.13.1-2.83.0
Novelty place preference11.711.912.6-3.63.4-3.5-3.5-3.5-3.53.5-3.23.4
Time in novel zone, NPP test12.813.214.0-3.73.6-3.7-3.7-3.6-3.73.7-3.33.6
Total zone transitions, NPP test1.52.13.11.7-1.31.81.31.21.6-1.31.4-1.4
Total locomotion distance, NPP test0.50.71.01.0-0.71.00.70.60.9-0.70.9-0.9
Locomotion velocity, NPP test0.81.21.51.2-0.91.21.00.91.1-1.01.2-1.2
Intraocular pressure0.70.91.61.1-1.31.01.11.20.8-0.70.6-0.9
Delta distance traveled before/after self-admin1.01.11.61.1-1.01.11.21.01.3-1.00.3-1.0
Delta ambulatory time before/after self-admin0.50.50.80.8-0.70.80.80.60.9-0.6-0.0-0.6
Parametrial fat weight0.10.20.50.5-0.30.50.20.30.3-0.30.7-0.3
Pavlov. Cond. lever latency2.02.53.1-1.71.6-1.8-1.5-1.4-1.61.6-1.41.7
Pavlov. Cond. magazine entry latency0.00.00.10.00.00.1-0.2-0.2-0.20.10.10.1
Pavlov. Cond. change in total contacts0.60.61.10.9-0.81.10.60.50.9-0.80.7-0.7
Pavlov. Cond. index score0.70.91.81.2-0.91.30.70.61.1-0.80.6-0.9
Pavlov. Cond. latency score1.31.72.61.5-1.31.61.11.01.3-1.21.1-1.3
Pavlov. Cond. lever contacts2.02.43.01.7-1.51.71.41.41.4-1.51.6-1.6
Pavlov. Cond. magazine entry number0.10.10.2-0.2-0.1-0.40.30.4-0.2-0.10.4-0.1
Pavlov. Cond. intertrial magazine entries0.20.30.80.3-0.30.20.40.50.4-0.60.9-0.7
Pavlov. Cond. lever-magazine prob. diff.0.40.51.20.9-0.71.10.50.40.8-0.50.4-0.6
Pavlov. Cond. response bias0.10.10.30.4-0.10.5-0.1-0.20.30.0-0.2-0.1
Pavlov. Cond. lever latency0.00.00.10.1-0.3-0.00.20.3-0.30.0-0.20.3
Pavlov. Cond. magazine entry latency0.00.00.20.00.10.2-0.0-0.20.5-0.0-0.1-0.1
Pavlov. Cond. change in total contacts1.01.42.01.2-1.01.31.11.01.4-1.21.2-1.3
Pavlov. Cond. index score0.10.10.40.20.10.30.0-0.10.6-0.10.1-0.3
Pavlov. Cond. latency score0.10.10.60.30.00.50.1-0.10.7-0.30.2-0.4
Pavlov. Cond. lever contacts0.20.20.6-0.60.8-0.5-0.6-0.7-0.10.4-0.20.1
Pavlov. Cond. magazine entry number0.10.20.40.2-0.50.10.40.6-0.1-0.50.5-0.3
Pavlov. Cond. intertrial magazine entries0.10.10.50.3-0.30.20.20.50.0-0.40.7-0.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.60.3-0.00.50.1-0.00.8-0.20.2-0.4
Pavlov. Cond. response bias0.10.10.4-0.40.6-0.3-0.5-0.6-0.00.3-0.2-0.1
Time in closed arm before self-admin0.20.20.3-0.50.5-0.5-0.4-0.5-0.30.3-0.50.3
Time in closed arm after self-admin0.10.10.3-0.40.3-0.5-0.4-0.2-0.50.30.10.3
Time in open arm before self-admin1.11.11.8-0.80.7-0.9-1.1-0.9-1.21.3-1.21.3
Time in open arm after self-admin0.00.00.1-0.10.10.0-0.1-0.2-0.00.2-0.40.2
Bone: periosteal estimation0.30.63.20.4-0.60.10.40.9-0.1-0.61.8-0.5
Bone: periosteal perimeter0.20.31.60.3-0.50.10.30.7-0.0-0.51.3-0.5
Bone: post-yield work2.12.93.91.8-1.71.81.81.52.0-1.71.1-1.8
Progressive ratio test 1 active lever presses1.61.72.01.4-1.41.41.41.31.2-1.30.9-1.2
Progressive ratio test 1 breakpoint1.81.82.21.5-1.51.41.51.41.3-1.30.9-1.2
Progressive ratio test 1 inactive lever presses1.01.11.61.2-1.11.11.21.01.3-1.10.4-1.1
Progressive ratio test 2 active lever presses1.01.01.91.3-1.01.41.10.81.3-0.8-0.1-0.8
Progressive ratio test 2 breakpoint0.60.71.31.0-0.81.10.80.41.2-0.6-0.6-0.5
Progressive ratio test 2 inactive lever presses0.91.02.11.2-0.91.31.10.71.5-0.9-0.0-0.9
Incentive Sensitization - Responses0.10.10.70.4-0.10.50.1-0.20.40.1-0.80.1
Incentive Sensitization - Breakpoint0.20.20.70.6-0.30.70.3-0.00.6-0.1-0.8-0.1
Sum of active levers in priming session hrs 5-62.52.43.21.7-1.61.61.81.61.7-1.50.7-1.5
Progressive ratio0.10.10.20.3-0.30.30.30.40.4-0.20.2-0.2
Food seeking constrained by brief footshock0.40.51.0-0.70.5-0.8-0.7-0.4-1.00.8-0.50.8
Seeking ratio, punishment vs. effort0.70.81.2-0.90.8-0.9-0.9-0.9-1.10.9-0.90.9
Retroperitoneal fat weight0.20.81.80.9-0.90.80.81.00.5-0.81.3-0.6
Reaction time number correct3.24.66.62.5-2.32.62.32.02.4-2.00.7-2.0
Reaction time mean minus median0.00.00.10.2-0.20.30.20.10.2-0.1-0.10.2
Reaction time mean minus median AUC0.10.20.5-0.20.3-0.1-0.3-0.4-0.20.3-0.70.7
Reaction time num false alarms0.00.00.1-0.10.1-0.1-0.1-0.1-0.30.3-0.20.0
Reaction time num false alarms AUC0.00.00.00.1-0.10.20.10.00.00.1-0.1-0.2
Reaction time trials correct on left3.24.66.62.5-2.32.62.32.02.4-2.00.7-2.0
Reaction time trials on left3.44.86.72.5-2.42.62.42.12.4-2.00.8-2.0
Reaction time mean1.52.12.51.4-1.51.51.61.51.5-1.51.1-1.4
Reaction time mean AUC1.11.51.91.2-1.31.21.41.31.3-1.20.9-1.1
Median of all reaction times1.42.02.41.4-1.41.41.61.41.6-1.41.0-1.4
Reaction time omissions0.30.41.80.3-0.70.20.50.80.0-0.61.3-0.6
Reaction time false alarm rate0.91.31.7-1.21.2-1.2-1.2-1.1-1.31.2-0.60.9
Reaction time premature initiation rate0.81.01.3-1.21.1-1.1-1.1-1.0-1.10.8-0.81.0
Reaction time premature initiations0.10.10.20.4-0.40.40.40.20.5-0.4-0.3-0.3
Std. dev. reaction times0.10.20.30.4-0.50.50.50.40.5-0.40.3-0.2
Reaction time trials completed3.44.86.72.5-2.42.62.42.12.4-2.00.8-2.0
Reaction time trials AUC3.24.66.32.5-2.32.52.32.02.3-2.00.9-2.0
Run reversals in cocaine runway, females0.10.10.8-0.20.0-0.1-0.1-0.40.20.1-0.90.2
Run reversals in cocaine runway, males0.40.40.50.7-0.60.70.60.60.7-0.60.7-0.6
Latency to leave start box in cocaine runway0.10.10.20.2-0.40.20.20.30.2-0.30.4-0.3
Latency to leave start box in cocaine runway, F0.10.10.30.2-0.50.20.30.30.1-0.30.4-0.3
Latency to leave start box in cocaine runway, M0.00.00.0-0.20.1-0.2-0.1-0.1-0.10.1-0.10.1
Std. dev. time between licks in bursts0.70.93.70.6-0.60.50.50.80.5-0.81.9-1.1
Total sessions with >9 infusions1.11.22.01.1-1.41.01.31.40.8-1.01.0-0.9
Short access day 1 total inactive lever presses0.80.92.2-0.60.8-0.6-0.8-1.0-0.51.1-1.51.1
Short access day 10 total inactive lever presses1.21.41.7-1.11.2-1.0-1.2-1.3-0.91.2-1.21.2
Short access day 1 total infusions0.80.81.11.0-0.91.01.00.91.1-0.80.6-0.8
Short access day 10 total infusions1.61.82.21.5-1.51.51.51.41.4-1.30.9-1.2
Short access total infusions2.22.53.21.8-1.81.71.71.61.6-1.41.0-1.3
Short access day 1 locomotion0.40.41.5-0.40.5-0.4-0.5-0.7-0.30.8-1.20.8
Short access day 10 total locomotion0.40.50.6-0.60.8-0.5-0.7-0.8-0.50.8-0.70.8
Short access total locomotion0.30.30.60.7-0.70.70.70.60.6-0.3-0.2-0.3
One hour access (0.3 mA shock)1.01.22.21.2-1.01.41.10.81.5-1.00.3-0.9
Compulsive drug intake0.50.51.50.5-0.50.50.60.70.6-0.81.2-0.7
One hour access (shock baseline)1.31.52.51.4-1.31.61.31.01.6-1.10.2-1.1
Social response proportion2.72.93.51.6-1.71.51.91.81.7-1.91.6-1.8
Social responses0.00.00.1-0.30.4-0.3-0.1-0.20.1-0.0-0.30.0
Social time2.33.04.51.7-2.11.52.02.11.2-1.61.6-1.6
Soleus weight10.931.935.7-5.85.7-5.8-5.9-5.5-6.05.9-4.25.8
Bone: stiffness0.10.20.80.2-0.40.00.30.60.0-0.40.9-0.2
Tibialis anterior weight0.20.51.2-0.50.8-0.5-0.8-0.8-0.51.1-0.60.8
Time to tail flick, vehicle, before self-admin1.01.11.60.9-1.10.81.01.10.7-1.11.3-1.1
Time to tail flick, vehicle, after self-admin2.22.43.31.6-1.51.71.71.41.8-1.60.8-1.6
Time to tail flick, test, before self-admin2.42.43.2-1.71.5-1.8-1.5-1.4-1.71.4-1.31.4
Time to tail flick, test, after self-admin3.73.84.0-2.01.9-2.0-2.0-2.0-1.92.0-2.01.9
Delta time to tail flick, vehicle, before/after SA1.01.01.51.1-0.91.21.00.91.2-1.00.7-1.0
Delta time to tail flick, test, before/after SA1.41.21.6-1.01.1-0.8-1.2-1.3-0.81.2-1.31.2
Tibia length3.610.014.93.0-3.22.93.03.32.6-3.23.9-3.1
Ambulatory time before self-admin1.21.31.6-1.21.2-1.2-1.2-1.1-1.21.1-0.71.1
Ambulatory time after self-admin0.10.10.3-0.40.6-0.4-0.4-0.5-0.20.3-0.50.3
Bone: tissue strength0.60.62.9-0.4-0.1-0.7-0.10.6-1.0-0.11.70.0
Total heroin consumption5.97.09.8-2.52.5-2.5-2.5-2.6-2.32.8-3.12.8
Bone: trabecular number6.39.911.3-3.03.2-2.9-3.2-3.3-2.73.2-3.43.2
Bone: trabecular spacing3.95.17.02.1-2.42.02.32.51.8-2.32.7-2.2
Bone: trabecular thickness0.40.50.7-0.80.7-0.8-0.7-0.7-0.80.7-0.60.6
Bone: trabecular tissue density0.40.61.60.7-0.80.60.70.80.6-0.91.2-0.6
Water consumed over 24 hours0.00.00.00.0-0.0-0.00.00.1-0.0-0.10.2-0.0
Number of responses in last shaping day0.50.51.9-0.40.6-0.3-0.5-0.8-0.10.6-1.40.7