Phf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	isoform ratio	NM_001414742.1	0.67	0.13	8.9e-06	0	0.06	0.09	0.04	3.4e-01	1.3e-07	5.4e-10	7.6e-05
2	Liver	isoform ratio	NM_001414742.1	0.4	0.14	1.9e-05	0.03	0.06	0.05	0.04	1.1e-04	6.3e-07	4.6e-06	5.8e-05
3	Liver	intron excision ratio	chr20_5018316_5018983	0.29	0.14	8.1e-05	0.01	0.03	0.02	0.01	2.6e-02	1.9e-04	2.2e-03	6.7e-03
4	Liver	isoform ratio	XM_017601588.2	0.34	0.13	8.7e-06	0.03	0.05	0.04	0.03	4.1e-04	6.6e-06	8.7e-06	5.1e-04
5	BLA	isoform ratio	NM_001414742.1	0.16	0.08	1.5e-03	0.06	0.03	0.02	0.04	6.7e-04	8.4e-03	4.7e-02	5.3e-03
6	Adipose	isoform ratio	XM_017601588.2	0.71	0.1	9.7e-08	-0	0.08	0.08	0.06	4.3e-01	6.2e-09	1.4e-09	2.5e-07
7	Adipose	intron excision ratio	chr20_5018316_5018983	0.76	0.07	0.0e+00	0.11	0.21	0.22	0.2	4.2e-12	2.3e-23	9.3e-24	1.1e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	1.3	2.2	5.3	0.9	2.3	1.4	-1.4	-1.7	-0.4	-1.5
Area under the delay curve	0.2	0.2	0.5	0.1	-0.7	-0.5	0.4	0.4	-0.6	0.0
BMI with tail	1.1	3.5	20.7	4.6	-0.1	0.2	0.1	-0.5	-0.6	1.7
BMI without tail	0.3	0.7	2.5	-1.6	-0.9	-0.0	0.4	-0.2	1.1	-0.0
Body weight	0.7	3.0	10.8	3.3	-2.2	-1.0	1.2	-0.1	-0.6	1.6
Weight adjusted by age	1.0	1.1	4.5	-0.2	-2.1	-1.1	0.9	1.0	-0.1	0.6
Bone surface	0.2	0.3	0.8	-0.3	0.1	-0.2	0.3	0.9	0.8	-0.6
Bone volume	0.2	0.4	1.1	0.7	1.0	0.6	-0.5	-0.3	0.1	-0.5
Breakpoint value in progressive ratio session	0.4	0.4	1.1	-0.9	0.1	-0.3	0.4	0.7	1.0	0.3
Number of licking bursts	2.1	2.4	5.2	-2.2	-1.0	-1.3	1.4	0.8	1.4	-2.3
Context. condit. distance diff. score	1.8	2.2	4.5	-1.5	-0.8	-2.1	2.1	1.3	0.9	-0.9
Locomotion velocity, session 1	0.3	0.4	0.8	0.6	-0.4	-0.7	0.4	0.9	-0.7	0.5
Locomotion distance, session 1	0.5	0.6	1.9	0.1	1.4	0.7	-0.7	-0.8	0.4	-0.9
Locomotion velocity, session 2	0.3	0.4	1.5	0.3	-0.0	-0.5	0.6	0.5	0.5	-1.2
Locomotion distance, session 2	0.1	0.1	0.2	0.5	0.4	-0.3	0.3	-0.1	-0.3	0.2
Locomotion velocity, session 3	0.5	0.6	1.3	0.6	1.1	1.0	-1.0	-0.7	-0.0	-0.3
Locomotion distance, session 3	0.4	0.4	1.5	0.0	1.2	0.5	-0.5	-0.7	-0.4	-0.4
Stereotopy head waving bouts, day 3	1.0	1.2	1.9	1.4	-1.2	-0.9	0.9	1.4	0.7	-1.1
Stereotopy head waving duration, day 3	0.6	0.8	1.8	1.0	-1.3	-0.8	0.7	1.2	-0.1	-0.2
Locomotion velocity, session 7	0.4	0.5	1.1	0.5	0.8	-0.3	0.1	-1.0	-1.1	0.2
Locomotion distance, session 7	1.2	1.5	7.2	-2.7	1.3	0.2	-0.5	-1.0	-0.4	0.3
Stereotopy head waving bouts, day 7	0.4	0.5	1.7	0.6	-0.3	0.1	-0.1	-0.3	-1.3	-1.1
Stereotopy head waving duration, day 7	0.5	0.6	1.5	1.2	-0.4	0.1	-0.1	-0.0	-1.0	-1.2
Locomotion velocity, session 8	3.2	3.8	7.5	0.4	-2.2	-2.7	2.7	2.5	0.7	-0.3
Locomotion distance, session 8	0.9	1.3	3.8	-0.4	-0.4	-1.9	1.9	1.0	0.7	-0.2
Degree of sensitization distance	1.2	1.2	3.1	-1.8	-1.0	-0.9	0.9	1.0	1.3	0.4
Degree of sensitization stereotypy	0.6	0.6	2.1	0.2	0.1	0.2	-0.2	-0.5	-1.4	-1.4
Conditioned locomotion	1.1	1.3	3.6	1.9	-0.9	-0.8	1.1	1.1	1.2	-0.1
Cocaine response after cond. corrected	0.4	0.4	2.0	1.4	-0.2	-0.4	0.7	-0.3	0.5	-0.0
Cocaine response after cond. not corrected	0.8	0.9	1.3	1.0	-1.1	-0.9	1.2	0.8	1.1	0.1
Cocaine response before conditioning	1.0	1.2	3.7	-1.0	-1.4	-0.5	0.5	1.9	1.2	-0.0
Saline control response	1.3	1.6	3.2	1.0	0.6	1.8	-1.6	-1.6	-1.1	-0.5
Bone: connectivity density	0.6	0.9	2.6	0.1	1.5	0.6	-0.6	-0.7	0.4	-1.6
Bone: cortical apparent density	1.0	1.3	2.8	1.0	1.2	1.7	-1.6	-1.1	-0.2	0.3
Bone: cortical area	0.3	0.5	2.4	-1.5	-0.5	-0.3	0.4	0.4	0.3	0.6
Bone: cortical porosity	1.1	1.2	3.9	-2.0	-0.3	0.1	-0.3	-0.3	-1.6	1.2
Bone: cortical porosity	1.9	2.0	9.3	-3.0	-1.0	-0.6	0.3	0.6	-1.2	1.4
Bone: cortical thickness	0.9	1.4	2.9	0.1	1.4	1.6	-1.5	-1.7	-0.1	0.0
Bone: cortical thickness	1.8	2.1	3.8	1.2	1.6	1.9	-1.6	-1.8	0.8	-0.8
Bone: cortical tissue density	0.8	1.1	2.4	1.1	1.0	1.5	-1.5	-0.9	-0.2	0.4
Condit. Reinf. active minus inactive responses	2.4	2.7	16.8	-4.1	0.3	0.4	-0.6	0.0	-0.3	1.0
Condit. Reinf. active-inactive response ratio	1.3	1.4	6.8	-2.6	0.4	1.0	-1.0	-0.6	-0.2	0.3
Condit. Reinf. active responses	2.1	2.6	13.2	-3.6	0.8	0.7	-1.0	-0.2	-0.0	1.6
Condit. Reinf. inactive responses	0.9	1.1	2.9	-0.4	1.7	1.1	-1.3	-0.8	0.1	1.1
Incentive salience index mean	1.8	2.2	11.0	-3.3	-0.5	-1.0	0.9	0.9	-0.0	1.2
Condit. Reinf. lever presses	1.3	1.7	3.3	-1.3	-0.7	-1.8	1.8	1.3	0.2	1.2
Condit. Reinf. active minus inactive responses	0.4	0.5	2.4	-1.5	-0.8	-0.4	0.3	0.5	-0.1	-0.3
Condit. Reinf. active-inactive response ratio	1.8	1.9	7.1	-2.7	-1.6	-1.1	1.0	1.0	-0.0	-0.6
Condit. Reinf. active responses	0.2	0.2	1.2	-1.1	-0.0	0.1	-0.2	0.4	0.0	0.2
Condit. Reinf. inactive responses	0.6	0.7	1.3	1.2	1.1	1.0	-0.9	-0.4	0.3	0.8
Condit. Reinf. lever presses	0.3	0.5	1.4	-1.2	0.2	0.2	-0.3	-0.2	-1.2	0.5
Condit. Reinf. lever reinforcers received	0.3	0.4	2.2	-1.5	-0.1	0.0	-0.1	0.5	-0.0	0.5
Conditioned reinforcement - actives	0.1	0.1	0.3	-0.2	-0.2	-0.3	0.1	0.6	-0.5	0.2
Conditioned reinforcement - inactives	0.7	0.8	3.9	-2.0	0.0	0.4	-0.7	-0.4	-0.2	0.9
Conditioned locomotion	0.5	0.6	1.4	0.1	-1.0	-1.0	0.7	0.6	-1.2	0.2
Patch foraging indifference point 0 sec	1.3	2.2	6.8	-0.1	0.8	1.8	-1.9	0.9	-0.1	2.6
Patch foraging indifference point AUC	0.5	0.6	2.2	-1.5	0.1	0.4	-0.4	-0.3	0.8	-0.8
Delay disc. indifference point, 0s delay	0.9	1.0	2.2	-0.2	-1.3	-1.5	1.3	0.9	-0.2	0.5
Delay disc. indifference point, 16s delay	0.8	0.8	2.9	1.7	0.3	0.6	-0.6	-0.4	-1.3	-0.4
Delay disc. indifference point, 2s delay	0.8	0.9	2.4	-0.5	-1.5	-1.3	0.9	1.0	-0.2	0.5
Delay disc. indifference point, 24s delay	0.6	0.6	2.2	0.8	-0.9	0.0	-0.2	0.1	-1.5	-0.4
Delay disc. indifference point, 4s delay	0.3	0.3	1.2	-0.5	-0.5	-0.3	0.1	1.1	0.4	0.6
Delay disc. indifference point, 8s delay	0.3	0.3	0.8	-0.7	-0.9	-0.6	0.5	0.1	-0.5	-0.1
Indifference point function ln k	0.8	1.1	5.6	0.3	-0.6	-0.8	1.0	2.4	0.5	0.3
Indifference point function log k	0.8	1.1	5.6	0.3	-0.6	-0.8	1.0	2.4	0.5	0.3
Patch foraging total patch changes 0 sec	1.5	2.4	7.2	-0.0	0.9	1.9	-2.1	0.7	-0.3	2.7
Patch foraging total patch changes 12 sec	1.4	1.8	4.3	-0.2	1.3	1.9	-2.1	0.9	0.9	1.3
Patch foraging total patch changes 18 sec	2.6	3.3	7.6	-0.2	2.4	2.8	-2.7	-1.3	0.0	0.7
Patch foraging total patch changes 24 sec	2.4	3.0	5.4	-0.2	2.0	2.2	-2.3	-2.1	-1.1	1.1
Patch foraging total patch changes 6 sec	1.3	1.9	4.4	1.4	1.3	1.9	-2.1	-0.7	-0.5	0.9
Patch foraging time to switch 0 sec	0.8	1.2	5.1	2.3	0.5	0.5	-0.3	-1.3	-0.4	-0.8
Patch foraging water rate 0 sec	0.2	0.3	1.4	0.3	-0.5	-0.3	0.1	0.4	-0.1	1.2
Patch foraging water rate 12 sec	0.5	0.7	1.5	0.7	1.2	1.0	-0.9	-1.0	-0.0	0.6
Patch foraging water rate 18 sec	0.4	0.6	2.4	1.5	0.2	0.3	-0.3	-1.1	-0.3	0.4
Patch foraging water rate 24 sec	0.7	1.0	1.4	-0.9	1.2	0.8	-1.0	-1.1	1.1	0.8
Patch foraging water rate 6 sec	0.2	0.3	0.8	-0.1	0.9	0.6	-0.7	-0.8	0.2	-0.0
Seeking ratio, delayed vs. immediate footshock	1.3	1.4	2.2	-0.8	1.5	1.5	-1.4	-0.2	1.5	-1.1
Distance traveled before self-admin	0.6	0.6	3.5	-0.2	-0.0	-0.4	0.7	0.4	1.9	-0.2
Distance traveled after self-admin	0.9	1.0	4.3	-1.5	-0.1	0.1	0.1	0.5	2.1	-0.2
Extensor digitorum longus weight	0.3	1.1	2.9	0.1	-1.4	-1.7	1.7	0.3	-0.0	0.2
Bone: elastic displacement	1.0	1.2	2.6	-1.6	0.7	0.9	-1.2	-1.2	-1.0	0.8
Bone: elastic work	0.5	0.6	3.2	-0.1	-0.2	0.0	-0.2	-0.6	-0.7	1.8
Bone: endosteal estimation	3.1	6.7	13.8	-1.4	-3.7	-2.9	3.0	3.3	1.1	1.4
Bone: endosteal perimeter	3.1	6.3	9.7	-2.2	-3.1	-2.9	3.1	2.9	1.5	1.0
Epididymis fat weight	4.2	9.8	17.4	4.2	3.1	3.7	-3.4	-3.7	-1.6	0.8
Delta time in closed arm before/after self-admin	1.3	1.3	2.4	-0.9	-1.4	-1.3	1.3	0.8	0.2	1.6
Delta time in open arm before/after self-admin	0.8	0.8	1.7	0.6	1.2	1.2	-1.3	-0.5	-0.1	-0.0
Diff in mean of infusions in LGA sessions	0.2	0.3	0.7	-0.5	0.6	-0.3	0.4	-0.2	0.5	-0.8
Delay discount exponential model param	0.2	0.2	0.4	0.3	0.6	0.4	-0.2	-0.3	0.6	0.0
Extinction: sum of active levers before priming	0.3	0.3	0.7	-0.3	-0.5	-0.6	0.6	0.8	0.8	0.2
Active lever presses in extinction session 6	0.8	0.8	2.5	1.6	-0.3	-0.2	0.1	-0.4	-1.4	0.9
Bone: final force	0.6	1.0	4.0	2.0	-0.1	0.6	-0.5	-0.6	0.2	1.3
Bone: final moment	0.5	0.8	2.2	1.5	-0.1	0.5	-0.5	-0.6	-0.2	1.5
Food consumed during 24 hour testing period	0.9	1.0	1.8	0.8	-1.3	-1.1	1.3	0.9	0.6	0.8
Glucose	5.7	8.6	18.0	-4.2	-3.4	-3.9	3.5	1.8	0.1	-0.8
Heart weight	0.2	0.3	1.4	-0.2	-0.7	-0.4	0.2	0.4	-0.1	1.2
Delay discount hyperbolic model param	0.2	0.2	0.5	0.6	0.7	0.5	-0.3	-0.5	0.4	-0.1
Intermittent access intake day 1-15 change	1.0	1.0	2.5	-1.6	1.0	1.1	-1.1	-0.8	0.5	-0.2
Intermittent access intake escalation	0.6	0.6	2.9	-1.7	0.4	0.4	-0.4	-0.1	0.7	-0.0
Intermittent access intake escalation 2	0.6	0.6	1.2	-0.4	-0.5	-1.0	1.0	1.1	0.4	-0.6
Intermitt. access day 1 inactive lever presses	1.6	1.7	4.7	-1.1	-0.9	-1.1	1.3	1.2	2.2	0.9
Intermitt. access day 15 inactive lever presses	0.8	0.8	4.0	-2.0	-0.5	0.3	-0.3	0.2	1.0	0.7
Intermitt. access escalation Index	0.2	0.2	0.9	0.1	0.6	-0.3	0.5	0.2	0.9	-0.1
Intermittent access day 1 total infusions	0.4	0.5	2.7	-0.2	-0.2	-0.3	0.0	-0.2	-1.7	-0.5
Intermittent access day 15 total infusions	0.5	0.5	2.7	-1.6	0.3	0.3	-0.4	-0.4	-0.5	-0.4
Intermittent access terminal intake (last 3 days)	0.5	0.5	3.0	-1.7	-0.3	-0.1	-0.2	0.0	-0.5	-0.4
Intermittent access total infusions	0.4	0.4	1.5	-1.1	-0.2	0.0	-0.3	-0.4	-1.2	-0.2
Intermittent access day 1 locomotion	0.2	0.2	1.0	-1.0	-0.3	-0.2	0.0	-0.2	-0.2	0.1
Intermittent access day 15 total locomotion	0.2	0.2	0.7	0.7	-0.4	-0.1	-0.0	0.1	-0.9	-0.0
Intermittent access total locomotion	0.4	0.5	1.7	1.3	-0.0	0.2	-0.3	-0.4	-1.2	-0.2
Intermittent access standard deviation	0.9	1.0	3.4	-1.8	-0.2	0.8	-0.8	-0.5	1.1	0.9
Left kidney weight	0.4	1.1	4.0	2.0	-0.6	-0.3	0.5	-0.9	-0.4	1.3
Right kidney weight	0.2	0.6	3.1	1.8	-0.7	-0.3	0.5	-0.4	0.6	0.1
Cocaine induced anxiety	0.9	1.0	3.0	1.7	1.0	0.1	0.1	0.3	1.7	0.2
Post-drug Anxiety	0.7	0.8	2.5	1.6	0.2	-0.2	0.5	0.7	1.5	-0.4
Baseline Anxiety	0.6	0.7	2.6	-0.8	-1.6	-0.7	0.6	0.4	-0.5	-0.3
Tail length	3.0	9.0	32.1	-5.7	-3.4	-2.5	2.4	1.4	2.0	-1.2
Length with tail	0.9	3.2	8.9	-2.0	-3.0	-2.2	1.9	0.9	0.3	0.4
Length without tail	1.6	3.5	16.3	4.0	-1.4	-1.1	1.0	0.5	-1.3	1.5
Times rat made contact with spout	2.0	2.3	4.0	-0.4	1.9	1.9	-2.0	-1.7	-1.2	-0.7
Lifetime Intake	0.6	0.6	2.1	-1.5	-0.7	-0.4	0.0	-0.1	-1.3	-0.2
Liver weight, left	0.2	0.3	1.8	1.3	-0.4	-0.2	0.3	0.2	-0.0	0.0
Liver weight, right	2.6	4.3	7.5	-2.7	-2.2	-2.1	2.0	2.3	2.0	0.5
Locomotor activity	0.7	1.1	2.8	-1.1	-0.6	-0.1	0.4	-1.5	1.7	-0.7
Locomotor testing distance	0.3	0.5	3.1	0.1	-0.4	0.0	0.3	-0.6	1.8	-0.2
Locomotor testing rearing	0.4	0.6	2.4	-0.3	-0.7	-0.5	0.6	-0.4	1.5	0.3
Locomotion in novel chamber	0.6	0.7	3.3	1.8	0.4	0.3	-0.2	-0.0	-1.0	-0.4
Locomotion in novel chamber post-restriction	0.2	0.2	0.7	-0.8	-0.7	-0.1	0.0	-0.1	0.2	-0.4
Fecal boli incidents, locomotor time 1	0.3	0.3	1.2	-0.5	0.2	-0.1	-0.1	0.1	-0.7	1.1
Change in fecal boli incidents, locomotor task	1.9	1.8	3.2	1.5	-1.7	-1.2	1.4	1.8	0.6	0.5
Time >=10cm from walls, locomotor time 1	2.1	2.1	4.4	1.0	-1.3	-1.2	1.4	2.0	2.1	0.7
Bouts of movement, locomotor time 1	0.4	0.5	1.3	-0.9	0.7	0.2	-0.0	-0.3	1.2	-0.8
Total resting periods, locomotor time 1	0.5	0.5	1.7	-1.3	0.3	-0.1	0.2	0.1	1.2	-0.7
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.4	0.2	-0.5	0.3	0.4	0.1	0.1
Distance moved, locomotor task time 1	0.2	0.3	1.2	1.1	-0.3	0.5	-0.4	-0.2	-0.2	0.2
Vertical activity count, locomotor time 1	1.3	1.4	7.4	2.7	-0.1	1.0	-0.8	-0.7	-0.3	0.3
Time >=10cm from walls, locomotor time 2	1.9	2.1	6.6	-0.8	-2.6	-1.4	1.3	1.3	0.4	1.2
Bouts of movement, locomotor time 2	0.5	0.5	2.1	-1.4	0.1	0.3	-0.2	0.7	0.8	0.6
Total resting periods, locomotor time 2	0.9	1.0	4.0	-2.0	-0.2	-0.1	0.2	1.2	1.1	0.5
Rest time, locomotor task time 2	1.1	1.3	2.6	0.3	-0.5	-1.5	1.6	1.3	1.5	-0.4
Distance moved, locomotor task time 2	0.8	1.0	3.4	0.9	-0.7	0.5	-0.6	-1.2	-1.8	-0.2
Vertical activity count, locomotor time 2	1.1	1.2	3.9	2.0	-0.8	0.3	-0.3	-1.1	-1.5	0.4
Light reinforcement 1	0.4	0.8	4.1	0.1	0.5	0.8	-0.5	0.4	2.0	-0.2
Light reinforcement 2	0.2	0.3	0.7	0.6	-0.4	-0.4	0.4	0.3	0.8	0.3
Bone: marrow area	3.1	6.7	13.8	-1.4	-3.7	-2.8	3.0	3.3	1.1	1.5
Bone: maximum diameter	2.0	3.7	5.4	-2.2	-2.0	-2.3	2.3	2.3	0.8	0.4
Bone: maximum force	0.2	0.4	1.4	0.9	-0.1	0.3	-0.3	-0.3	-0.0	1.2
Bone: maximum moment	0.2	0.3	1.9	0.4	-0.3	0.1	-0.3	-0.2	-0.4	1.4
Mean time between licks in bursts	2.2	3.1	5.2	-1.5	-1.4	-2.0	2.1	2.3	1.8	-0.9
Mean num. licks in bursts	3.0	3.6	5.4	1.9	1.9	2.2	-2.3	-1.6	-1.8	1.5
Cd content in liver	1.6	1.8	5.0	1.9	0.6	0.6	-0.7	-2.2	-1.6	-0.7
Co content in liver	1.0	1.2	6.2	2.5	0.2	0.8	-0.7	-0.8	-0.0	-0.0
Cu content in liver	1.7	2.0	3.9	0.6	2.0	1.6	-1.7	-1.8	-1.1	0.4
Fe content in liver	1.2	1.4	4.0	2.0	0.5	0.7	-0.9	-0.4	-1.8	0.8
K content in liver	0.9	0.9	2.3	1.5	-0.4	-1.0	1.2	-0.7	-0.0	-0.8
Mg content in liver	2.7	2.8	7.0	0.7	-1.7	-2.6	2.6	0.1	-0.0	-1.6
Mn content in liver	4.2	4.7	9.5	-2.1	-2.6	-3.0	3.1	1.3	1.3	0.1
Na content in liver	0.8	0.8	3.2	0.5	0.2	-0.0	0.1	-1.8	0.1	-1.5
Rb content in liver	0.6	0.7	1.2	0.9	-0.7	-1.1	1.1	-0.6	-0.9	-0.3
Se content in liver	2.2	2.7	4.8	-1.8	-1.7	-2.2	2.1	1.6	0.7	-0.6
Sr content in liver	1.3	1.2	2.0	1.2	-1.4	-1.3	1.3	0.8	-1.0	0.4
Zn content in liver	2.8	3.1	6.1	2.5	-1.4	-1.4	1.2	2.2	-1.0	2.0
Bone: minimum diameter	2.4	4.5	7.4	-2.3	-2.7	-2.4	2.5	2.2	0.6	1.0
Time in familiar zone, hab. session 1	3.2	3.0	5.4	-0.9	2.3	2.0	-2.1	-2.0	-1.6	0.3
Time in novel zone, hab. session 1	2.0	1.9	3.0	0.7	-1.7	-1.4	1.4	1.4	1.7	-1.0
Total zone transitions, hab. session 1	0.6	0.9	3.8	-2.0	0.7	0.0	0.0	-0.3	1.3	-0.4
Total locomotion distance, hab. session 1	0.6	0.8	2.5	-1.6	0.8	-0.1	0.2	-0.4	1.3	-0.8
Locomotion velocity, hab. session 1	0.7	1.0	4.4	-2.1	0.6	-0.1	0.2	-0.3	1.2	-0.6
Time in familiar zone, hab. session 2	2.3	2.3	3.8	1.1	1.9	1.8	-1.6	-0.7	1.6	-1.6
Time in novel zone, hab. session 2	1.1	1.1	2.8	-0.5	-1.2	-0.8	0.4	0.3	-1.7	1.4
Total zone transitions, hab. session 2	0.5	0.6	2.5	0.3	0.9	0.3	-0.0	-0.1	1.6	-0.8
Total locomotion distance, hab. session 2	0.6	0.8	3.3	-0.2	1.2	0.1	0.2	-0.3	1.8	-0.8
Locomotion velocity, hab. session 2	0.5	0.7	3.0	-0.5	1.0	-0.2	0.4	-0.1	1.7	-0.8
Novel to familiar place preference ratio	1.1	1.1	6.6	-2.6	-0.2	-0.0	-0.1	0.2	-0.1	1.2
Novelty place preference	1.1	1.1	6.4	-2.5	-0.3	-0.1	-0.0	0.4	-0.0	1.2
Time in novel zone, NPP test	1.0	1.1	6.3	-2.5	-0.3	-0.1	-0.1	0.4	0.0	0.9
Total zone transitions, NPP test	0.5	0.7	2.4	1.6	0.8	-0.1	0.1	-0.3	-0.2	-1.3
Total locomotion distance, NPP test	0.6	0.8	2.8	1.7	0.7	-0.3	0.2	-0.9	-0.8	-0.7
Locomotion velocity, NPP test	0.5	0.7	2.3	1.5	0.8	-0.3	0.4	-1.0	-0.6	-0.6
Intraocular pressure	0.6	0.8	1.8	0.3	1.3	1.2	-1.3	-0.7	-0.3	0.1
Delta distance traveled before/after self-admin	0.5	0.6	3.1	-1.8	-0.2	0.6	-0.7	0.0	-0.2	0.1
Delta ambulatory time before/after self-admin	0.5	0.6	3.4	-1.9	-0.4	0.3	-0.3	0.4	0.5	-0.0
Parametrial fat weight	0.7	1.3	3.5	1.9	1.4	1.3	-1.0	-0.8	0.6	0.2
Pavlov. Cond. lever latency	2.4	3.1	5.4	2.2	1.3	2.3	-2.1	-2.0	0.2	-0.9
Pavlov. Cond. magazine entry latency	1.3	1.7	6.4	-2.5	-0.9	-1.3	1.2	1.3	0.1	0.2
Pavlov. Cond. change in total contacts	1.8	1.9	7.8	-2.8	-1.0	-1.0	0.9	1.2	0.1	1.0
Pavlov. Cond. index score	2.2	2.7	4.9	-2.0	-1.5	-2.2	2.1	1.8	-0.4	0.7
Pavlov. Cond. latency score	2.3	2.9	5.2	-2.1	-1.5	-2.3	2.1	1.9	-0.3	0.7
Pavlov. Cond. lever contacts	2.9	3.4	6.7	-1.9	-1.7	-2.6	2.4	1.8	-0.5	1.2
Pavlov. Cond. magazine entry number	0.6	0.7	2.1	1.4	0.5	0.9	-0.8	-1.1	-0.0	0.1
Pavlov. Cond. intertrial magazine entries	1.5	1.8	3.0	1.3	1.5	1.6	-1.7	-1.6	-0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.7	4.6	-2.1	-1.4	-2.2	2.0	1.6	-0.6	0.9
Pavlov. Cond. response bias	1.4	1.7	4.0	-2.0	-1.0	-1.7	1.5	1.2	-0.3	0.3
Pavlov. Cond. lever latency	0.4	0.6	2.3	-0.4	-0.5	-0.4	0.4	0.9	1.5	0.0
Pavlov. Cond. magazine entry latency	0.6	0.7	2.6	-0.4	-0.8	-0.8	0.7	0.4	-1.6	0.5
Pavlov. Cond. change in total contacts	0.3	0.5	1.9	-0.5	0.4	0.5	-0.5	-0.3	-1.4	0.6
Pavlov. Cond. index score	0.4	0.5	2.7	-0.4	0.1	0.0	-0.1	-0.4	-1.7	0.4
Pavlov. Cond. latency score	0.3	0.4	2.2	-0.5	0.1	0.1	-0.1	-0.4	-1.5	0.5
Pavlov. Cond. lever contacts	1.0	1.3	2.9	0.3	1.1	1.1	-1.1	-1.7	-1.5	0.0
Pavlov. Cond. magazine entry number	0.3	0.3	1.8	-0.0	0.2	0.2	-0.2	0.2	1.4	-0.5
Pavlov. Cond. intertrial magazine entries	1.5	1.9	5.2	-1.9	-0.1	-0.4	0.4	1.6	2.3	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	3.0	-0.3	0.0	0.0	-0.1	-0.5	-1.7	0.5
Pavlov. Cond. response bias	0.6	0.8	3.0	0.0	0.7	0.6	-0.5	-1.1	-1.7	0.2
Time in closed arm before self-admin	0.7	0.8	3.8	2.0	-0.1	-0.1	0.0	-0.1	-0.8	-0.9
Time in closed arm after self-admin	0.3	0.3	1.4	0.7	-0.1	-0.3	0.2	-0.2	-1.2	0.4
Time in open arm before self-admin	1.3	1.4	8.9	-3.0	-0.6	-0.5	0.4	0.1	-0.0	0.4
Time in open arm after self-admin	0.4	0.4	2.6	-1.6	0.2	0.3	-0.4	0.0	0.4	0.0
Bone: periosteal estimation	1.7	3.5	6.3	-1.9	-2.5	-1.9	2.0	2.2	1.0	1.2
Bone: periosteal perimeter	1.7	2.8	4.6	-1.8	-2.1	-1.8	2.0	1.7	0.8	1.0
Bone: post-yield work	1.0	1.3	2.2	-1.4	-1.4	-1.5	1.4	1.1	0.0	0.5
Progressive ratio test 1 active lever presses	0.8	0.8	2.5	1.0	-1.1	-0.7	0.5	0.2	-1.6	-0.3
Progressive ratio test 1 breakpoint	0.7	0.8	1.8	1.1	-1.2	-0.7	0.6	0.3	-1.4	-0.2
Progressive ratio test 1 inactive lever presses	0.9	1.0	4.9	2.2	0.4	0.7	-0.6	-0.2	-0.6	0.6
Progressive ratio test 2 active lever presses	0.2	0.3	0.6	0.4	0.6	0.5	-0.5	-0.3	-0.8	-0.4
Progressive ratio test 2 breakpoint	0.5	0.6	1.2	0.5	1.1	0.8	-0.8	-0.7	-0.8	-0.4
Progressive ratio test 2 inactive lever presses	0.3	0.3	0.7	-0.8	-0.7	-0.5	0.2	0.6	-0.5	-0.1
Incentive Sensitization - Responses	0.8	0.8	2.5	-0.5	1.6	1.0	-0.8	-0.5	0.8	-0.2
Incentive Sensitization - Breakpoint	0.9	0.9	3.1	-0.6	1.8	1.1	-0.9	-0.6	0.9	-0.1
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.1	0.1	-1.1	-0.9	0.8	0.6	-0.5	-0.9
Progressive ratio	1.2	1.4	2.5	1.0	0.8	1.6	-1.2	-0.6	1.1	1.6
Food seeking constrained by brief footshock	0.4	0.5	2.2	0.9	0.1	0.3	-0.4	-0.4	-1.5	-0.2
Seeking ratio, punishment vs. effort	0.9	1.1	2.6	-0.5	-0.8	-1.2	0.9	0.4	-1.3	-1.6
Retroperitoneal fat weight	0.3	1.1	4.1	2.0	-0.1	0.1	-0.1	-0.3	-1.1	1.5
Reaction time number correct	0.6	0.9	1.9	0.3	1.1	1.4	-1.4	-0.4	0.7	0.4
Reaction time mean minus median	1.1	1.4	5.1	-2.3	-0.9	-1.4	1.3	0.3	-0.1	-0.5
Reaction time mean minus median AUC	1.8	2.4	10.3	-3.2	-1.2	-1.6	1.3	-0.2	-0.9	-0.1
Reaction time num false alarms	1.3	1.8	7.8	-2.8	-0.5	-0.6	0.7	1.0	1.6	0.4
Reaction time num false alarms AUC	1.6	2.2	9.2	-3.0	-0.4	-0.4	0.6	1.0	2.1	-0.2
Reaction time trials correct on left	0.6	0.9	1.9	0.3	1.1	1.4	-1.4	-0.4	0.7	0.4
Reaction time trials on left	0.5	0.8	1.8	0.2	1.0	1.3	-1.3	-0.4	0.7	0.5
Reaction time mean	2.1	2.9	6.0	-1.3	-2.2	-2.4	2.4	1.2	-0.4	0.8
Reaction time mean AUC	2.0	2.7	5.5	-1.3	-2.1	-2.3	2.2	1.1	-0.6	0.9
Median of all reaction times	1.9	2.6	5.0	-0.8	-2.1	-2.2	2.2	1.5	-0.1	1.0
Reaction time omissions	1.0	1.4	5.6	-2.4	-0.9	-1.2	1.3	-0.1	0.6	-0.1
Reaction time false alarm rate	1.6	2.3	8.2	-2.9	-1.2	-1.3	1.4	1.1	1.2	-0.1
Reaction time premature initiation rate	1.6	2.1	9.7	3.1	-1.0	-0.6	0.7	1.1	-0.5	1.3
Reaction time premature initiations	1.3	1.8	9.1	3.0	-0.4	0.1	-0.1	1.0	-0.1	1.5
Std. dev. reaction times	2.0	2.8	6.8	-2.6	-2.0	-2.1	2.0	0.7	-0.2	-0.0
Reaction time trials completed	0.5	0.8	1.8	0.2	1.0	1.3	-1.3	-0.4	0.7	0.5
Reaction time trials AUC	0.6	0.8	1.8	0.5	1.1	1.3	-1.3	-0.5	0.7	0.4
Run reversals in cocaine runway, females	2.9	2.8	9.8	3.1	0.8	0.9	-1.0	-1.4	-2.3	0.4
Run reversals in cocaine runway, males	0.7	0.7	1.9	-1.4	-0.5	-0.8	0.8	1.0	0.0	-0.6
Latency to leave start box in cocaine runway	1.0	1.1	2.4	-0.8	-1.4	-1.4	1.5	0.9	0.3	-0.2
Latency to leave start box in cocaine runway, F	1.3	1.4	6.7	-2.6	-0.9	-1.0	1.0	0.5	0.6	0.1
Latency to leave start box in cocaine runway, M	1.2	1.1	6.1	2.5	-0.5	-0.4	0.8	0.5	-0.5	-0.5
Std. dev. time between licks in bursts	4.3	5.1	11.1	-1.2	-2.2	-2.7	2.8	3.3	1.6	-0.6
Total sessions with >9 infusions	1.9	2.1	12.2	-3.5	-1.0	-1.0	0.6	0.2	-0.3	0.4
Short access day 1 total inactive lever presses	1.7	1.9	4.7	-0.2	-1.8	-2.2	1.9	1.2	-0.7	0.1
Short access day 10 total inactive lever presses	2.2	2.5	9.3	-2.3	0.4	-0.1	0.5	0.9	3.1	1.2
Short access day 1 total infusions	1.9	2.0	7.1	-2.7	-1.6	-1.3	0.9	1.0	-1.0	0.4
Short access day 10 total infusions	0.9	1.0	5.2	-2.3	-0.9	-0.4	0.2	0.2	0.2	0.7
Short access total infusions	1.4	1.6	6.6	-2.6	-1.5	-1.0	0.6	0.4	-0.7	0.3
Short access day 1 locomotion	3.0	3.2	18.0	-4.2	-0.7	-0.9	0.9	0.7	1.2	0.6
Short access day 10 total locomotion	2.7	3.0	5.0	-2.1	-1.8	-1.4	1.5	2.2	2.0	0.0
Short access total locomotion	2.1	2.2	7.2	-2.7	-1.6	-1.1	1.1	1.1	1.2	0.6
One hour access (0.3 mA shock)	0.2	0.3	0.8	-0.7	0.9	0.0	-0.0	0.2	-0.2	-0.6
Compulsive drug intake	1.4	1.4	4.7	2.2	0.0	-1.0	1.3	1.6	-0.2	-0.4
One hour access (shock baseline)	0.3	0.4	1.0	-0.5	0.2	0.2	-0.6	-0.8	-1.0	-0.6
Social response proportion	1.6	1.7	2.8	-1.7	-1.3	-1.1	1.0	0.7	1.4	1.7
Social responses	2.6	3.4	16.2	-4.0	-0.7	-0.4	0.5	-0.1	2.5	0.5
Social time	3.6	4.8	14.2	-3.2	-0.6	-1.4	1.8	1.7	3.8	-0.8
Soleus weight	2.7	7.9	16.9	-0.9	-4.0	-4.1	4.1	1.9	1.2	-0.1
Bone: stiffness	0.3	0.5	0.8	0.9	0.6	0.9	-0.8	-0.6	0.8	-0.2
Tibialis anterior weight	0.3	1.1	2.7	1.6	1.4	1.2	-1.0	-0.5	0.1	-0.5
Time to tail flick, vehicle, before self-admin	1.4	1.4	3.8	1.0	1.4	0.7	-0.4	-0.4	1.9	-1.6
Time to tail flick, vehicle, after self-admin	1.2	1.3	5.3	-2.3	-0.7	-0.8	0.9	0.4	1.3	0.4
Time to tail flick, test, before self-admin	0.8	0.8	1.8	0.2	1.3	1.1	-0.9	-1.0	0.8	-0.1
Time to tail flick, test, after self-admin	0.5	0.5	1.5	-1.2	1.2	0.3	-0.4	-0.6	0.2	-0.6
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	2.7	-1.4	-1.0	-0.8	0.5	-0.1	-1.6	1.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.7	-0.8	0.4	-0.2	0.1	-0.4	-0.3	0.1
Tibia length	0.9	2.6	5.2	-1.0	-2.3	-1.8	2.1	1.3	1.6	0.1
Ambulatory time before self-admin	0.3	0.3	1.4	-0.9	0.4	-0.0	0.1	-0.2	1.2	-0.3
Ambulatory time after self-admin	0.6	0.7	2.6	-1.3	0.0	0.2	-0.0	0.3	1.6	-0.5
Bone: tissue strength	0.2	0.2	0.6	0.4	-0.0	0.0	-0.3	-0.5	-0.7	0.7
Total heroin consumption	0.1	0.1	0.5	-0.3	0.4	0.1	-0.0	-0.4	0.7	-0.0
Bone: trabecular number	1.9	3.0	7.5	0.6	2.7	1.7	-1.8	-2.0	0.0	-1.7
Bone: trabecular spacing	1.6	2.1	6.3	0.1	-2.5	-1.4	1.4	1.5	-0.8	1.3
Bone: trabecular thickness	1.3	1.6	3.7	0.8	1.9	1.1	-1.0	-1.5	-0.0	-1.5
Bone: trabecular tissue density	0.3	0.4	1.2	-1.1	-0.5	-0.1	-0.0	0.6	-0.9	0.7
Water consumed over 24 hours	0.5	0.5	0.9	-0.4	-0.9	-0.9	1.0	0.6	0.1	-0.9
Number of responses in last shaping day	3.7	3.9	7.1	1.3	-2.7	-2.3	2.2	2.1	-1.5	-1.2