Hub : Genes

Pgpep1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Pgpep1	0.05	0.03	2.7e-07	0.02	0.05	0.03	0.04	1.4e-03	6.2e-06	2.8e-04	3.0e-05
2	Liver	gene expression	Pgpep1	0.06	0.03	8.0e-08	0.02	0.05	0.02	0.03	2.5e-03	2.0e-06	8.7e-04	3.6e-04
3	Liver	isoform ratio	NM_201988.2	0.04	0.03	2.6e-04	0.01	0.02	0.02	0.01	3.9e-02	2.1e-03	4.0e-03	9.6e-03
4	Liver	isoform ratio	XM_063275159.1	0.04	0.03	2.3e-04	0.01	0.02	0.01	0.01	4.8e-02	3.1e-03	1.0e-02	2.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.3	2.2	4.1	-2.0	-1.3	1.4	-1.1
Area under the delay curve	0.4	0.5	0.6	0.8	0.7	-0.7	0.6
BMI with tail	2.9	10.1	11.7	-3.2	-3.4	3.1	-3.0
BMI without tail	4.1	12.6	14.4	-3.5	-3.8	3.5	-3.5
Body weight	8.4	36.9	39.9	-6.3	-6.2	6.0	-5.8
Weight adjusted by age	2.7	4.1	4.3	-2.0	-2.1	2.0	-2.0
Bone surface	0.9	1.6	2.7	-1.7	-1.2	1.1	-0.9
Bone volume	1.9	3.3	5.1	-2.2	-1.8	1.7	-1.5
Breakpoint value in progressive ratio session	0.3	0.3	0.5	-0.6	-0.7	0.5	-0.4
Number of licking bursts	0.2	0.3	0.4	0.5	0.6	-0.5	0.4
Context. condit. distance diff. score	0.0	0.0	0.1	-0.0	0.3	0.2	-0.3
Locomotion velocity, session 1	0.4	0.4	0.7	-0.5	-0.9	0.6	-0.4
Locomotion distance, session 1	0.3	0.4	0.7	0.5	0.5	-0.7	0.9
Locomotion velocity, session 2	2.6	3.0	3.5	-1.5	-1.9	1.8	-1.8
Locomotion distance, session 2	0.7	1.0	1.5	0.8	0.9	-1.1	1.2
Locomotion velocity, session 3	0.1	0.2	0.3	0.5	0.5	-0.3	0.2
Locomotion distance, session 3	0.1	0.2	0.2	0.1	0.5	-0.4	0.5
Stereotopy head waving bouts, day 3	0.3	0.3	0.9	0.5	0.9	-0.3	0.3
Stereotopy head waving duration, day 3	0.0	0.1	0.2	0.1	0.4	0.1	-0.2
Locomotion velocity, session 7	1.5	1.6	1.9	1.4	1.2	-1.3	1.2
Locomotion distance, session 7	2.4	3.1	3.2	1.7	1.7	-1.8	1.8
Stereotopy head waving bouts, day 7	0.9	1.0	1.3	-1.1	-0.8	1.1	-1.0
Stereotopy head waving duration, day 7	1.8	2.1	2.5	-1.4	-1.2	1.6	-1.6
Locomotion velocity, session 8	0.2	0.2	0.4	0.6	0.5	-0.3	0.3
Locomotion distance, session 8	0.1	0.1	0.1	0.1	0.3	-0.3	0.4
Degree of sensitization distance	1.1	1.2	1.6	1.3	1.0	-1.1	1.0
Degree of sensitization stereotypy	1.6	1.8	2.3	-1.5	-1.2	1.4	-1.3
Conditioned locomotion	0.1	0.1	0.1	0.2	0.3	-0.3	0.3
Cocaine response after cond. corrected	0.5	0.6	1.2	0.8	1.1	-0.6	0.5
Cocaine response after cond. not corrected	1.0	1.1	1.6	1.2	1.3	-0.9	0.8
Cocaine response before conditioning	0.2	0.2	0.3	0.5	0.1	-0.5	0.5
Saline control response	0.1	0.1	0.2	-0.4	-0.3	0.2	-0.2
Bone: connectivity density	0.8	1.2	2.4	-1.5	-1.1	0.9	-0.7
Bone: cortical apparent density	0.1	0.1	0.2	0.3	0.1	-0.4	0.5
Bone: cortical area	9.5	14.6	16.5	-4.1	-3.8	3.8	-3.7
Bone: cortical porosity	0.1	0.1	0.2	-0.2	-0.5	0.1	-0.0
Bone: cortical porosity	0.1	0.1	0.2	-0.3	-0.5	0.2	-0.1
Bone: cortical thickness	7.2	12.0	14.6	-3.8	-3.3	3.4	-3.3
Bone: cortical thickness	2.9	3.4	4.9	-2.2	-1.3	1.9	-1.8
Bone: cortical tissue density	0.2	0.2	0.3	0.5	0.2	-0.6	0.6
Condit. Reinf. active minus inactive responses	1.1	1.2	1.9	-1.4	-0.9	1.1	-1.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	-0.9	-0.3	0.6	-0.5
Condit. Reinf. active responses	1.6	2.0	2.6	-1.6	-1.3	1.4	-1.3
Condit. Reinf. inactive responses	0.7	0.8	1.0	-0.8	-1.0	0.9	-0.9
Incentive salience index mean	2.7	3.3	4.3	-2.1	-1.8	1.8	-1.6
Condit. Reinf. lever presses	3.9	5.4	6.5	-2.6	-2.4	2.3	-2.0
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.0	0.0	-0.1	0.2
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.7	-0.8	-0.8	0.8	-0.8
Condit. Reinf. active responses	0.6	0.9	1.0	1.0	0.8	-1.0	1.0
Condit. Reinf. inactive responses	3.0	3.9	4.9	2.2	1.7	-2.0	1.9
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.0	-0.4	0.2	-0.3
Condit. Reinf. lever reinforcers received	0.2	0.3	0.4	0.6	0.4	-0.6	0.5
Conditioned reinforcement - actives	1.0	1.7	1.8	-1.2	-1.3	1.3	-1.3
Conditioned reinforcement - inactives	6.5	9.5	10.2	-3.0	-2.9	3.2	-3.2
Conditioned locomotion	0.7	0.9	1.2	-0.8	-0.9	1.0	-1.1
Patch foraging indifference point 0 sec	3.1	5.8	6.3	-2.2	-2.4	2.5	-2.5
Patch foraging indifference point AUC	0.1	0.1	0.1	0.4	0.1	-0.3	0.3
Delay disc. indifference point, 0s delay	3.2	3.5	4.0	2.0	1.9	-1.8	1.8
Delay disc. indifference point, 16s delay	2.7	2.9	3.7	1.9	1.6	-1.7	1.6
Delay disc. indifference point, 2s delay	0.4	0.4	0.5	0.6	0.7	-0.7	0.7
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.1
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	-0.2	-0.2	0.1	-0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.5	0.3	-0.3	0.2
Indifference point function ln k	0.4	0.8	0.9	-0.9	-0.8	0.9	-0.9
Indifference point function log k	0.4	0.8	0.9	-0.9	-0.8	0.9	-0.9
Patch foraging total patch changes 0 sec	4.4	8.3	9.0	-2.6	-2.9	2.9	-3.0
Patch foraging total patch changes 12 sec	0.7	0.9	1.3	-0.7	-0.9	1.0	-1.2
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	0.4	0.1	-0.2	0.1
Patch foraging total patch changes 24 sec	0.4	0.7	0.7	-0.8	-0.7	0.8	-0.8
Patch foraging total patch changes 6 sec	2.0	3.1	3.8	-1.4	-1.8	1.8	-1.9
Patch foraging time to switch 0 sec	0.8	1.6	1.8	1.3	1.2	-1.3	1.3
Patch foraging water rate 0 sec	1.5	3.1	3.2	-1.7	-1.8	1.8	-1.8
Patch foraging water rate 12 sec	0.4	0.8	1.0	-1.0	-1.0	0.9	-0.8
Patch foraging water rate 18 sec	0.0	0.0	0.1	-0.2	-0.3	-0.0	0.2
Patch foraging water rate 24 sec	1.0	1.4	2.0	-1.4	-1.3	1.1	-0.9
Patch foraging water rate 6 sec	1.1	1.7	1.7	-1.2	-1.3	1.3	-1.3
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	0.9	1.0	0.7	-0.8	0.7
Distance traveled before self-admin	1.4	1.8	2.1	-1.2	-1.4	1.4	-1.4
Distance traveled after self-admin	2.6	3.2	3.5	-1.7	-1.9	1.8	-1.8
Extensor digitorum longus weight	0.7	2.8	3.1	-1.6	-1.6	1.7	-1.8
Bone: elastic displacement	0.0	0.0	0.0	-0.1	0.1	-0.1	0.2
Bone: elastic work	2.6	3.4	3.7	-1.9	-1.8	1.9	-1.8
Bone: endosteal estimation	0.0	0.0	0.1	0.3	-0.1	-0.2	0.1
Bone: endosteal perimeter	0.7	1.4	1.5	-1.1	-1.2	1.2	-1.2
Epididymis fat weight	1.3	4.4	6.3	-2.2	-2.5	1.9	-1.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.4	0.3	-0.3	0.2
Delta time in open arm before/after self-admin	0.5	0.5	0.7	0.6	0.6	-0.8	0.8
Diff in mean of infusions in LGA sessions	1.4	1.7	2.2	-0.9	-1.5	1.3	-1.4
Delay discount exponential model param	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.0	-0.0	-0.3	0.5
Active lever presses in extinction session 6	0.1	0.1	0.2	0.5	0.3	-0.4	0.3
Bone: final force	9.5	15.1	15.4	-3.9	-3.9	3.9	-3.9
Bone: final moment	8.2	13.1	13.2	-3.6	-3.6	3.6	-3.6
Food consumed during 24 hour testing period	0.0	0.0	0.1	-0.1	0.0	-0.2	0.3
Glucose	1.9	3.0	3.6	-1.6	-1.9	1.7	-1.7
Heart weight	2.8	4.4	5.3	-2.3	-1.7	2.2	-2.1
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.3	-0.3	0.2	-0.1
Intermittent access intake day 1-15 change	0.2	0.4	0.7	-0.9	-0.6	0.6	-0.4
Intermittent access intake escalation	0.1	0.1	0.4	-0.6	-0.3	0.3	-0.1
Intermittent access intake escalation 2	0.5	0.6	0.8	-0.9	-0.9	0.7	-0.6
Intermitt. access day 1 inactive lever presses	0.1	0.4	0.4	-0.6	-0.5	0.6	-0.7
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	0.1	0.2	0.0	-0.0
Intermitt. access escalation Index	0.9	1.3	1.4	1.1	1.2	-1.1	1.1
Intermittent access day 1 total infusions	0.2	0.3	0.5	-0.2	-0.4	0.6	-0.7
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.3
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.1
Intermittent access total infusions	0.5	0.6	0.7	-0.7	-0.8	0.8	-0.9
Intermittent access day 1 locomotion	1.1	1.4	1.7	-1.0	-1.2	1.2	-1.3
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.3
Intermittent access total locomotion	1.4	1.7	1.8	-1.2	-1.3	1.3	-1.4
Intermittent access standard deviation	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.4
Left kidney weight	1.1	4.9	5.9	-2.1	-2.4	2.2	-2.1
Right kidney weight	2.3	10.6	13.5	-3.2	-3.7	3.1	-3.0
Cocaine induced anxiety	1.3	1.9	2.5	-1.1	-1.4	1.5	-1.6
Post-drug Anxiety	0.0	0.0	0.1	-0.0	-0.2	0.2	-0.3
Baseline Anxiety	2.9	3.3	3.8	1.6	1.8	-1.9	2.0
Tail length	1.4	5.3	5.8	-2.3	-2.4	2.3	-2.3
Length with tail	3.5	15.0	16.5	-4.1	-4.0	3.8	-3.7
Length without tail	2.8	9.1	11.4	-3.4	-2.9	3.0	-2.8
Times rat made contact with spout	0.2	0.2	0.3	0.3	0.4	-0.5	0.6
Lifetime Intake	1.4	1.7	2.0	-1.2	-1.2	1.3	-1.4
Liver weight, left	0.0	0.1	0.1	-0.1	-0.1	-0.2	0.4
Liver weight, right	2.1	3.7	5.2	-1.9	-2.3	1.7	-1.7
Locomotor activity	0.7	1.1	1.8	-1.3	-1.2	0.9	-0.6
Locomotor testing distance	0.0	0.0	0.1	-0.3	0.0	-0.1	0.3
Locomotor testing rearing	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.3
Locomotion in novel chamber	0.3	0.4	0.5	-0.7	-0.7	0.5	-0.4
Locomotion in novel chamber post-restriction	0.4	0.6	1.6	-1.2	-0.7	0.6	-0.3
Fecal boli incidents, locomotor time 1	0.5	0.7	0.8	0.9	0.7	-0.9	0.9
Change in fecal boli incidents, locomotor task	0.4	0.4	0.7	0.8	0.6	-0.6	0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.5	0.2	-0.4	0.3
Bouts of movement, locomotor time 1	0.2	0.2	0.4	0.4	0.2	-0.6	0.7
Total resting periods, locomotor time 1	0.7	0.8	1.2	0.8	0.6	-1.0	1.1
Rest time, locomotor task time 1	0.2	0.3	0.5	0.7	0.6	-0.5	0.4
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.2	0.1	-0.1	0.1
Vertical activity count, locomotor time 1	0.1	0.2	0.3	-0.5	-0.5	0.4	-0.3
Time >=10cm from walls, locomotor time 2	1.5	2.2	2.7	1.4	1.6	-1.4	1.4
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.2
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.3	-0.2	0.3	-0.3
Rest time, locomotor task time 2	0.6	0.7	0.8	-0.8	-0.8	0.9	-0.9
Distance moved, locomotor task time 2	0.7	0.8	1.0	0.9	1.0	-0.9	0.8
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.0	0.4	-0.1	0.1
Light reinforcement 1	0.0	0.1	0.2	0.5	0.1	-0.3	0.2
Light reinforcement 2	0.2	0.3	0.7	0.9	0.5	-0.4	0.2
Bone: marrow area	0.0	0.0	0.1	0.3	0.0	-0.2	0.2
Bone: maximum diameter	3.3	6.1	6.4	-2.5	-2.3	2.5	-2.5
Bone: maximum force	9.9	17.6	19.0	-4.4	-4.3	4.1	-4.0
Bone: maximum moment	8.1	14.1	15.2	-3.9	-3.8	3.7	-3.6
Mean time between licks in bursts	1.9	4.7	5.2	-2.1	-2.3	2.2	-2.2
Mean num. licks in bursts	0.1	0.1	0.2	-0.5	-0.3	0.2	-0.1
Cd content in liver	0.7	0.8	1.4	-1.2	-0.6	0.9	-0.8
Co content in liver	0.0	0.0	0.0	-0.2	-0.1	0.2	-0.2
Cu content in liver	0.3	0.4	0.6	0.3	0.7	-0.6	0.8
Fe content in liver	1.1	1.3	1.4	1.1	1.1	-1.2	1.2
K content in liver	3.4	3.3	3.8	1.9	1.9	-1.7	1.6
Mg content in liver	0.2	0.2	0.3	0.4	0.5	-0.3	0.3
Mn content in liver	0.1	0.1	0.2	-0.3	-0.3	0.4	-0.4
Na content in liver	2.2	2.4	2.8	1.5	1.4	-1.6	1.7
Rb content in liver	0.5	0.6	0.9	-0.7	-0.3	0.9	-1.0
Se content in liver	0.0	0.1	0.1	0.1	0.3	-0.2	0.3
Sr content in liver	0.4	0.4	0.5	0.6	0.3	-0.7	0.7
Zn content in liver	0.0	0.0	0.0	0.0	-0.1	-0.0	0.0
Bone: minimum diameter	2.7	5.0	6.1	-2.3	-2.5	2.1	-2.1
Time in familiar zone, hab. session 1	0.2	0.2	0.4	-0.4	-0.6	0.4	-0.3
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.0	0.4	-0.1	0.0
Total zone transitions, hab. session 1	0.2	0.2	0.4	0.4	0.2	-0.5	0.6
Total locomotion distance, hab. session 1	0.5	0.8	1.4	0.6	0.6	-1.0	1.2
Locomotion velocity, hab. session 1	0.6	0.8	1.3	0.7	0.6	-1.0	1.2
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.2	-0.3	0.2	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.2	0.3	-0.2	0.2
Total zone transitions, hab. session 2	0.1	0.1	0.1	0.2	0.2	-0.3	0.3
Total locomotion distance, hab. session 2	0.0	0.0	0.1	-0.3	-0.0	0.0	0.2
Locomotion velocity, hab. session 2	0.0	0.0	0.1	-0.2	0.1	-0.1	0.3
Novel to familiar place preference ratio	0.0	0.0	0.1	0.2	0.1	-0.2	0.2
Novelty place preference	0.1	0.1	0.1	0.4	0.3	-0.4	0.3
Time in novel zone, NPP test	0.4	0.4	0.4	0.6	0.5	-0.7	0.6
Total zone transitions, NPP test	0.3	0.4	0.6	0.5	0.6	-0.7	0.8
Total locomotion distance, NPP test	0.5	0.7	1.2	0.5	0.8	-0.9	1.1
Locomotion velocity, NPP test	0.6	0.8	1.3	0.7	0.8	-1.0	1.1
Intraocular pressure	0.9	1.3	1.7	-1.1	-0.9	1.3	-1.3
Delta distance traveled before/after self-admin	1.2	1.3	1.6	-1.1	-1.3	1.1	-1.0
Delta ambulatory time before/after self-admin	0.3	0.3	0.4	-0.6	-0.6	0.6	-0.5
Parametrial fat weight	1.9	4.4	5.3	-1.7	-2.3	2.1	-2.3
Pavlov. Cond. lever latency	1.5	1.9	2.6	1.6	1.4	-1.3	1.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	-0.6	-0.7	0.6	-0.5
Pavlov. Cond. change in total contacts	3.1	3.3	3.6	-1.9	-1.8	1.8	-1.8
Pavlov. Cond. index score	0.5	0.7	0.9	-0.9	-0.9	0.7	-0.6
Pavlov. Cond. latency score	0.6	0.8	1.0	-1.0	-1.0	0.8	-0.7
Pavlov. Cond. lever contacts	1.6	1.9	2.4	-1.5	-1.5	1.3	-1.2
Pavlov. Cond. magazine entry number	0.5	0.6	0.8	0.8	0.9	-0.7	0.7
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	-0.7	0.1	0.4	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	-0.8	-0.9	0.7	-0.6
Pavlov. Cond. response bias	0.7	0.9	1.1	-1.0	-1.0	0.9	-0.8
Pavlov. Cond. lever latency	1.1	1.5	1.8	1.0	1.3	-1.2	1.3
Pavlov. Cond. magazine entry latency	0.9	1.1	1.2	-1.0	-1.1	1.0	-1.1
Pavlov. Cond. change in total contacts	1.1	1.7	2.1	-1.1	-1.3	1.4	-1.5
Pavlov. Cond. index score	1.6	2.2	2.6	-1.3	-1.5	1.5	-1.6
Pavlov. Cond. latency score	1.0	1.4	1.7	-1.0	-1.2	1.2	-1.3
Pavlov. Cond. lever contacts	1.0	1.3	1.6	-0.9	-1.2	1.2	-1.3
Pavlov. Cond. magazine entry number	2.4	2.9	3.3	1.5	1.8	-1.7	1.8
Pavlov. Cond. intertrial magazine entries	1.1	1.7	2.1	1.3	1.2	-1.4	1.4
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.5	2.9	-1.4	-1.6	1.6	-1.7
Pavlov. Cond. response bias	1.5	2.0	2.4	-1.2	-1.5	1.4	-1.5
Time in closed arm before self-admin	7.2	9.2	11.3	-2.6	-2.9	3.2	-3.4
Time in closed arm after self-admin	2.9	3.1	4.6	-1.4	-1.6	1.9	-2.1
Time in open arm before self-admin	0.2	0.2	0.5	0.1	0.3	-0.5	0.7
Time in open arm after self-admin	0.3	0.4	0.9	0.0	0.4	-0.6	0.9
Bone: periosteal estimation	2.1	4.4	4.8	-2.1	-2.2	2.1	-2.0
Bone: periosteal perimeter	5.5	9.4	9.7	-3.1	-3.0	3.1	-3.1
Bone: post-yield work	0.0	0.0	0.1	-0.1	0.1	-0.1	0.2
Progressive ratio test 1 active lever presses	3.1	3.8	4.3	-1.8	-1.9	2.0	-2.1
Progressive ratio test 1 breakpoint	2.8	3.4	3.9	-1.7	-1.8	1.9	-2.0
Progressive ratio test 1 inactive lever presses	1.7	2.4	2.7	-1.5	-1.5	1.6	-1.6
Progressive ratio test 2 active lever presses	0.3	0.4	0.5	-0.5	-0.6	0.7	-0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	-0.4	-0.5	0.5	-0.6
Progressive ratio test 2 inactive lever presses	1.0	1.7	1.9	-1.3	-1.2	1.4	-1.4
Incentive Sensitization - Responses	0.5	0.6	0.8	0.9	0.8	-0.8	0.7
Incentive Sensitization - Breakpoint	0.8	1.1	1.3	1.1	1.0	-1.1	1.0
Sum of active levers in priming session hrs 5-6	3.7	3.5	4.5	1.4	1.9	-1.9	2.1
Progressive ratio	0.1	0.2	0.3	0.4	0.5	-0.4	0.4
Food seeking constrained by brief footshock	0.4	0.5	0.9	0.2	0.9	-0.6	0.8
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	-0.1	0.3	-0.3	0.4
Retroperitoneal fat weight	2.8	11.9	12.7	-3.3	-3.6	3.4	-3.5
Reaction time number correct	0.2	0.3	0.7	-0.7	-0.8	0.4	-0.1
Reaction time mean minus median	0.0	0.0	0.1	-0.0	-0.2	0.1	-0.1
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.2	-0.3	0.3	-0.3
Reaction time num false alarms	0.9	1.2	1.4	-1.0	-1.0	1.2	-1.2
Reaction time num false alarms AUC	0.5	0.7	0.9	-0.8	-0.7	0.9	-1.0
Reaction time trials correct on left	0.2	0.3	0.7	-0.7	-0.8	0.4	-0.1
Reaction time trials on left	0.2	0.4	0.9	-0.8	-0.9	0.4	-0.2
Reaction time mean	0.2	0.2	0.4	-0.2	-0.5	0.5	-0.6
Reaction time mean AUC	0.0	0.0	0.1	0.4	-0.0	-0.0	-0.1
Median of all reaction times	0.1	0.1	0.3	0.0	-0.2	0.3	-0.5
Reaction time omissions	1.7	2.5	3.2	-1.4	-1.8	1.6	-1.6
Reaction time false alarm rate	0.4	0.6	1.0	-0.7	-0.5	0.9	-1.0
Reaction time premature initiation rate	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1
Reaction time premature initiations	0.2	0.4	0.6	-0.8	-0.7	0.5	-0.2
Std. dev. reaction times	0.4	0.7	1.0	-0.7	-1.0	0.8	-0.8
Reaction time trials completed	0.2	0.4	0.9	-0.8	-0.9	0.4	-0.2
Reaction time trials AUC	0.3	0.5	1.0	-0.9	-1.0	0.5	-0.3
Run reversals in cocaine runway, females	4.0	4.0	4.2	-1.9	-2.0	2.1	-2.1
Run reversals in cocaine runway, males	0.8	0.8	1.0	0.9	0.8	-0.9	1.0
Latency to leave start box in cocaine runway	0.0	0.0	0.0	0.0	-0.1	-0.1	0.1
Latency to leave start box in cocaine runway, F	0.5	0.5	0.6	-0.8	-0.8	0.7	-0.6
Latency to leave start box in cocaine runway, M	1.7	1.5	2.0	1.4	1.2	-1.2	1.1
Std. dev. time between licks in bursts	2.4	3.3	3.4	-1.8	-1.8	1.8	-1.8
Total sessions with >9 infusions	4.5	5.5	6.0	-2.3	-2.3	2.4	-2.4
Short access day 1 total inactive lever presses	0.5	0.7	0.9	-0.8	-0.6	0.9	-1.0
Short access day 10 total inactive lever presses	0.1	0.2	0.5	0.7	0.5	-0.3	0.2
Short access day 1 total infusions	3.8	5.1	5.3	-2.3	-2.2	2.3	-2.3
Short access day 10 total infusions	0.7	0.9	1.0	-1.0	-0.9	1.0	-1.0
Short access total infusions	1.8	2.3	2.6	-1.4	-1.5	1.6	-1.6
Short access day 1 locomotion	5.8	7.1	8.2	-2.6	-2.5	2.8	-2.9
Short access day 10 total locomotion	2.6	4.9	5.9	-2.4	-2.2	2.2	-2.0
Short access total locomotion	3.7	4.4	4.8	-2.2	-2.0	2.1	-2.1
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.3	0.1	0.3	-0.3
Compulsive drug intake	2.1	2.5	2.8	1.5	1.7	-1.5	1.5
One hour access (shock baseline)	1.6	2.5	2.9	-1.5	-1.5	1.6	-1.7
Social response proportion	3.4	3.8	5.3	-2.3	-1.6	2.0	-1.9
Social responses	0.7	0.9	1.8	-1.3	-0.8	0.9	-0.7
Social time	0.2	0.3	0.3	-0.6	-0.1	0.6	-0.6
Soleus weight	0.6	1.7	2.1	-1.0	-1.4	1.3	-1.4
Bone: stiffness	7.6	12.3	12.7	-3.6	-3.5	3.5	-3.5
Tibialis anterior weight	0.5	1.6	2.1	-1.5	-1.4	1.2	-1.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.2	0.4	0.4	-0.5	0.5
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	-0.3	-0.5	0.4	-0.5
Time to tail flick, test, before self-admin	2.0	2.1	2.6	-1.4	-1.2	1.6	-1.6
Time to tail flick, test, after self-admin	1.9	2.0	2.3	1.4	1.5	-1.4	1.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2
Delta time to tail flick, test, before/after SA	2.7	2.7	3.2	1.5	1.5	-1.8	1.8
Tibia length	1.1	2.9	3.3	-1.8	-1.6	1.7	-1.7
Ambulatory time before self-admin	1.9	2.8	3.2	-1.4	-1.8	1.7	-1.8
Ambulatory time after self-admin	4.8	5.6	6.3	-2.3	-2.5	2.4	-2.3
Bone: tissue strength	0.2	0.2	0.4	-0.2	-0.7	0.3	-0.4
Total heroin consumption	0.1	0.2	0.3	-0.3	-0.6	0.4	-0.4
Bone: trabecular number	1.8	2.9	4.6	-2.1	-1.7	1.5	-1.4
Bone: trabecular spacing	0.3	0.4	0.7	0.9	0.6	-0.6	0.5
Bone: trabecular thickness	1.4	1.8	2.8	-1.7	-1.3	1.2	-1.1
Bone: trabecular tissue density	0.2	0.3	0.4	0.5	0.2	-0.6	0.7
Water consumed over 24 hours	0.2	0.2	0.4	-0.6	-0.5	0.3	-0.2
Number of responses in last shaping day	0.4	0.4	0.8	-0.9	-0.5	0.6	-0.5