Hub : Genes

Pfkm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Pfkm 0.08 0.05 1.1e-12 0.11 0.11 0.11 0.11 3.4e-12 3.5e-12 3.4e-12 4.7e-12
2 Adipose mRNA stability Pfkm 0.11 0.06 3.3e-16 0.11 0.12 0.12 0.12 1.6e-12 6.8e-13 5.3e-13 1.4e-13
3 IL gene expression Pfkm 0.16 0.12 2.3e-03 0.11 0.12 0.11 0.11 1.2e-03 9.9e-04 1.4e-03 1.3e-03
4 Liver mRNA stability Pfkm 0.14 0.09 6.1e-16 0.12 0.13 0.12 0.12 2.2e-13 5.7e-14 9.4e-14 1.6e-13
5 Brain mRNA stability Pfkm 0.06 0.04 1.2e-06 0.04 0.03 0.04 0.03 1.1e-04 6.6e-04 1.5e-04 3.6e-04
6 Liver gene expression Pfkm 0.12 0.08 3.9e-14 0.11 0.1 0.11 0.11 4.2e-12 1.3e-11 8.5e-12 3.1e-12
7 Adipose gene expression Pfkm 0.03 0.02 2.2e-04 0.02 0.02 0.02 0.02 9.0e-04 9.9e-04 3.4e-03 1.9e-03
8 LHb gene expression Pfkm 0.33 0.27 2.6e-03 0.07 0.03 0.05 0.04 1.2e-02 6.1e-02 2.4e-02 4.0e-02
9 Brain gene expression Pfkm 0.27 0.12 0.0e+00 0.35 0.33 0.36 0.35 1.3e-33 6.0e-32 1.1e-34 4.5e-34
10 RMTg gene expression Pfkm 0.15 0.15 6.0e-03 0.05 0.05 0.02 0.05 1.7e-02 1.8e-02 1.2e-01 2.2e-02
11 pVTA gene expression Pfkm 0.12 0.08 1.2e-05 0.14 0.13 0.12 0.05 7.5e-07 3.2e-06 4.8e-06 2.8e-03
12 BLA mRNA stability Pfkm 0.06 0.05 8.5e-04 0.08 0.06 0.09 0.08 4.2e-05 2.6e-04 2.4e-05 5.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density8.614.418.7-4.3-3.63.8-4.04.1-3.8-4.2-4.0-4.2-3.1-3.12.9
Area under the delay curve1.31.42.3-1.4-1.31.3-1.51.1-1.3-1.1-1.2-1.3-1.0-0.8-0.2
BMI with tail4.514.619.2-4.1-4.44.2-4.44.1-4.3-3.8-3.9-3.9-3.4-3.2-0.2
BMI without tail0.20.30.7-0.7-0.70.5-0.50.8-0.7-0.6-0.8-0.3-0.4-0.10.1
Body weight6.828.534.6-5.7-5.95.7-5.75.8-5.8-5.5-5.7-5.5-5.1-4.7-0.6
Weight adjusted by age2.73.04.8-1.7-1.81.7-1.41.8-1.8-1.8-2.0-1.6-2.1-2.2-0.4
Bone surface10.017.722.0-4.7-4.34.4-4.54.6-4.3-4.6-4.5-4.6-3.7-3.71.9
Bone volume7.412.616.6-4.1-3.43.6-3.73.9-3.5-3.9-3.7-3.9-3.1-3.02.4
Breakpoint value in progressive ratio session0.20.20.6-0.4-0.20.4-0.40.3-0.2-0.5-0.4-0.5-0.4-0.50.8
Number of licking bursts0.20.20.80.30.4-0.50.9-0.10.50.10.30.6-0.4-0.40.1
Context. condit. distance diff. score0.40.50.7-0.7-0.80.7-0.60.7-0.8-0.9-0.7-0.6-0.6-0.7-0.3
Locomotion velocity, session 11.01.02.91.00.8-0.91.0-1.20.61.01.21.10.70.8-1.7
Locomotion distance, session 12.93.75.31.91.9-1.91.5-2.31.92.02.31.72.32.3-0.1
Locomotion velocity, session 20.30.40.90.50.5-0.50.4-1.00.40.41.00.30.70.7-0.2
Locomotion distance, session 22.53.45.01.91.9-1.81.5-2.22.01.92.21.62.12.1-0.3
Locomotion velocity, session 33.13.64.81.92.0-1.91.7-2.12.11.82.11.82.22.2-0.3
Locomotion distance, session 34.65.06.12.22.4-2.42.2-2.42.52.32.32.22.42.40.2
Stereotopy head waving bouts, day 30.80.92.2-0.8-1.01.0-0.80.8-0.9-0.9-0.7-1.0-1.3-1.50.2
Stereotopy head waving duration, day 30.30.30.9-0.5-0.60.5-0.40.2-0.6-0.5-0.2-0.6-0.8-1.00.2
Locomotion velocity, session 70.00.00.10.20.2-0.20.2-0.00.20.1-0.00.40.10.20.3
Locomotion distance, session 70.91.11.91.01.2-1.21.3-0.81.21.10.61.40.91.1-0.0
Stereotopy head waving bouts, day 70.91.02.5-0.9-1.11.0-0.70.8-1.0-0.9-0.9-1.0-1.4-1.6-0.7
Stereotopy head waving duration, day 71.31.62.8-1.1-1.41.3-1.01.0-1.3-1.2-1.0-1.2-1.5-1.7-1.1
Locomotion velocity, session 80.10.21.3-0.2-0.40.3-0.4-0.1-0.4-0.30.1-0.3-0.1-0.0-1.1
Locomotion distance, session 81.11.62.71.31.2-1.20.9-1.41.21.11.41.11.61.6-0.7
Degree of sensitization distance0.80.81.3-0.9-1.00.9-0.81.1-1.0-0.8-1.1-0.6-1.0-0.9-0.3
Degree of sensitization stereotypy0.50.62.3-0.5-0.70.6-0.40.4-0.7-0.5-0.5-0.4-0.9-1.0-1.5
Conditioned locomotion0.10.10.7-0.00.0-0.10.50.00.10.1-0.20.1-0.7-0.8-0.1
Cocaine response after cond. corrected0.20.20.80.0-0.10.3-0.8-0.2-0.20.20.2-0.30.80.9-0.4
Cocaine response after cond. not corrected0.91.02.31.01.1-0.80.4-1.10.81.01.10.61.51.5-0.2
Cocaine response before conditioning4.85.99.32.63.0-2.83.1-2.42.82.32.42.51.91.70.3
Saline control response0.10.21.5-0.20.4-0.30.30.30.4-0.1-0.3-0.1-0.0-0.21.2
Bone: connectivity density5.99.212.0-3.4-3.03.2-3.43.3-3.1-3.4-3.2-3.5-2.4-2.31.7
Bone: cortical apparent density0.40.51.00.80.8-0.81.0-0.70.70.80.60.70.30.2-0.2
Bone: cortical area9.614.517.8-4.2-4.14.0-3.94.1-4.0-4.1-4.0-4.0-3.6-3.51.0
Bone: cortical porosity1.71.93.01.41.7-1.61.7-1.31.61.51.31.60.90.90.1
Bone: cortical porosity2.22.43.71.61.8-1.71.9-1.51.81.71.51.81.01.1-0.1
Bone: cortical thickness4.06.68.5-2.9-2.72.7-2.72.6-2.7-2.8-2.6-2.8-2.4-2.31.2
Bone: cortical thickness0.30.40.7-0.7-0.60.6-0.70.7-0.5-0.6-0.8-0.7-0.3-0.40.4
Bone: cortical tissue density0.50.61.20.90.9-1.01.1-0.80.90.90.70.80.50.3-0.3
Condit. Reinf. active minus inactive responses0.20.20.80.40.4-0.30.0-0.50.40.30.6-0.00.60.50.9
Condit. Reinf. active-inactive response ratio0.10.20.5-0.3-0.30.4-0.70.2-0.3-0.3-0.1-0.60.1-0.00.7
Condit. Reinf. active responses0.70.81.61.01.0-0.80.6-1.30.90.91.20.61.00.90.2
Condit. Reinf. inactive responses2.63.14.01.91.9-1.91.9-2.01.91.81.81.91.51.5-0.5
Incentive salience index mean0.10.11.1-0.2-0.00.2-0.30.0-0.1-0.3-0.0-0.5-0.0-0.11.0
Condit. Reinf. lever presses0.30.41.1-0.7-0.40.6-0.60.3-0.5-0.7-0.4-0.8-0.5-0.61.1
Condit. Reinf. active minus inactive responses0.00.00.10.20.1-0.10.20.10.20.0-0.10.4-0.00.0-0.3
Condit. Reinf. active-inactive response ratio0.20.30.30.60.5-0.40.4-0.50.50.40.50.60.50.5-0.6
Condit. Reinf. active responses0.20.30.70.60.6-0.60.7-0.20.70.50.20.80.30.4-0.1
Condit. Reinf. inactive responses0.80.91.81.11.1-1.11.4-0.71.21.10.71.30.60.5-0.1
Condit. Reinf. lever presses0.00.00.10.10.2-0.10.20.30.20.1-0.20.30.2-0.10.4
Condit. Reinf. lever reinforcers received0.50.71.30.90.9-0.91.0-0.51.00.80.61.10.70.70.1
Conditioned reinforcement - actives1.31.31.71.31.3-1.31.3-1.21.31.11.11.21.11.00.2
Conditioned reinforcement - inactives1.21.42.01.31.2-1.21.0-1.21.21.31.31.21.21.4-0.1
Conditioned locomotion0.20.30.80.60.6-0.70.9-0.40.60.50.20.80.20.2-0.1
Patch foraging indifference point 0 sec1.32.13.71.61.3-1.61.6-1.21.41.31.21.91.71.8-0.1
Patch foraging indifference point AUC0.40.53.40.40.5-0.40.6-0.40.70.50.20.60.30.2-1.9
Delay disc. indifference point, 0s delay1.41.62.3-1.3-1.31.3-1.21.1-1.4-1.0-1.4-1.1-1.5-1.2-0.9
Delay disc. indifference point, 16s delay1.61.62.2-1.4-1.31.3-1.31.3-1.3-1.4-1.5-1.3-1.3-1.1-0.6
Delay disc. indifference point, 2s delay0.91.01.4-1.1-1.01.1-1.00.9-1.1-0.8-1.1-1.1-1.1-1.2-0.2
Delay disc. indifference point, 24s delay1.71.62.1-1.4-1.31.3-1.21.3-1.2-1.4-1.4-1.3-1.3-1.2-0.9
Delay disc. indifference point, 4s delay0.40.41.1-0.6-0.70.7-1.10.6-0.7-0.6-0.4-0.8-0.2-0.10.5
Delay disc. indifference point, 8s delay3.23.35.0-2.0-2.02.0-2.21.7-2.0-1.8-1.7-2.1-1.6-1.4-0.2
Indifference point function ln k3.34.56.0-2.2-2.42.3-2.22.1-2.5-2.4-2.1-2.0-2.1-2.10.0
Indifference point function log k3.34.56.0-2.2-2.42.3-2.22.1-2.5-2.4-2.1-2.0-2.1-2.10.0
Patch foraging total patch changes 0 sec1.32.13.81.61.3-1.61.6-1.21.41.31.12.01.51.7-0.1
Patch foraging total patch changes 12 sec1.21.52.31.41.3-1.41.5-1.11.41.31.01.41.21.0-0.4
Patch foraging total patch changes 18 sec3.14.06.62.12.1-2.22.4-1.62.21.91.42.61.71.9-1.4
Patch foraging total patch changes 24 sec1.01.22.51.21.1-1.31.6-0.81.21.10.71.50.70.9-0.2
Patch foraging total patch changes 6 sec2.03.03.81.91.9-1.91.9-1.51.91.71.51.91.81.7-0.2
Patch foraging time to switch 0 sec2.64.15.52.22.3-2.22.3-2.02.32.12.12.01.71.60.7
Patch foraging water rate 0 sec3.65.87.7-2.6-2.82.6-2.62.4-2.7-2.5-2.6-2.2-2.3-2.1-0.9
Patch foraging water rate 12 sec3.24.96.0-2.3-2.32.4-2.32.3-2.3-2.4-2.2-2.3-2.3-2.2-0.7
Patch foraging water rate 18 sec0.50.71.1-0.8-1.11.0-1.00.9-0.9-0.9-0.9-0.7-0.7-0.7-0.1
Patch foraging water rate 24 sec2.94.15.9-2.1-2.22.0-1.81.9-2.2-2.0-1.9-2.1-2.2-2.4-1.0
Patch foraging water rate 6 sec3.75.46.8-2.4-2.62.6-2.42.3-2.6-2.5-2.3-2.4-2.3-2.40.1
Seeking ratio, delayed vs. immediate footshock0.30.31.0-0.6-0.50.6-1.00.3-0.6-0.3-0.1-0.8-0.00.00.7
Distance traveled before self-admin0.91.01.71.11.0-1.11.3-1.11.01.00.81.30.70.6-0.5
Distance traveled after self-admin0.20.20.40.30.3-0.40.3-0.50.30.30.40.40.60.6-0.5
Extensor digitorum longus weight5.119.924.3-4.6-4.94.9-4.74.8-4.8-4.6-4.9-4.2-4.4-4.3-0.7
Bone: elastic displacement4.45.06.22.32.3-2.52.5-2.32.52.42.32.52.02.10.3
Bone: elastic work0.10.10.8-0.00.3-0.30.4-0.10.60.20.10.30.10.10.9
Bone: endosteal estimation6.514.117.4-3.9-4.14.0-3.84.2-3.9-3.9-4.0-3.7-3.8-3.9-0.5
Bone: endosteal perimeter6.413.217.1-3.9-3.93.8-3.64.1-3.6-3.8-3.9-3.7-3.6-3.8-0.1
Epididymis fat weight0.40.91.7-1.0-1.21.1-1.31.1-1.1-0.9-0.9-0.8-0.8-0.2-0.5
Delta time in closed arm before/after self-admin0.40.42.6-0.4-0.30.4-0.80.2-0.3-0.40.1-0.70.10.11.6
Delta time in open arm before/after self-admin3.73.64.61.92.0-2.02.1-2.12.02.11.82.11.71.6-1.1
Diff in mean of infusions in LGA sessions1.31.44.4-1.2-1.01.2-1.30.9-1.1-1.0-0.9-1.3-0.8-0.92.1
Delay discount exponential model param1.11.22.11.21.2-1.21.4-1.01.21.11.11.30.90.80.1
Extinction: sum of active levers before priming0.40.40.7-0.6-0.60.7-0.60.5-0.6-0.5-0.8-0.4-0.7-0.6-0.0
Active lever presses in extinction session 60.40.40.7-0.7-0.60.7-0.80.7-0.6-0.8-0.5-0.9-0.3-0.50.4
Bone: final force9.114.818.1-4.3-4.14.1-4.24.0-4.1-4.3-3.9-4.1-3.4-3.40.9
Bone: final moment9.214.918.4-4.3-4.24.2-4.34.1-4.1-4.3-3.9-4.2-3.3-3.31.0
Food consumed during 24 hour testing period1.31.52.6-1.4-1.31.3-1.61.3-1.2-1.3-1.2-1.5-0.6-1.00.8
Glucose0.20.30.8-0.3-0.40.4-0.20.8-0.5-0.5-0.9-0.6-0.7-0.70.5
Heart weight0.00.10.20.00.10.1-0.3-0.20.10.20.4-0.30.30.2-0.2
Delay discount hyperbolic model param1.11.11.91.21.2-1.21.4-1.01.21.01.01.20.90.70.1
Intermittent access intake day 1-15 change1.01.01.41.10.9-1.00.8-0.90.91.01.20.91.21.10.7
Intermittent access intake escalation0.70.71.20.90.7-0.80.5-0.70.70.91.10.71.01.00.8
Intermittent access intake escalation 21.11.11.51.11.0-1.00.8-1.01.01.01.21.01.21.21.2
Intermitt. access day 1 inactive lever presses2.93.25.62.01.9-2.02.4-1.72.01.81.42.31.31.3-0.4
Intermitt. access day 15 inactive lever presses0.80.91.61.01.0-1.11.2-0.91.01.00.71.30.71.0-0.3
Intermitt. access escalation Index0.20.20.40.60.4-0.50.7-0.20.40.30.40.50.20.1-0.1
Intermittent access day 1 total infusions1.11.31.61.21.2-1.21.1-1.21.11.21.31.01.21.1-0.3
Intermittent access day 15 total infusions1.92.12.71.61.5-1.61.5-1.41.51.51.61.51.51.40.6
Intermittent access terminal intake (last 3 days)2.12.22.81.61.5-1.71.6-1.41.51.51.61.61.51.60.7
Intermittent access total infusions1.92.22.71.61.5-1.71.6-1.51.51.51.51.51.51.5-0.1
Intermittent access day 1 locomotion0.80.81.81.00.9-1.11.4-0.61.00.90.61.10.40.5-0.7
Intermittent access day 15 total locomotion0.70.82.01.01.0-1.11.4-0.51.10.70.61.20.40.6-0.2
Intermittent access total locomotion2.12.45.01.71.7-1.92.2-1.21.81.51.12.00.91.1-0.7
Intermittent access standard deviation0.60.60.90.80.7-0.70.6-0.90.60.80.90.61.00.70.8
Left kidney weight0.30.93.0-0.9-1.01.2-1.70.7-1.1-0.8-0.4-1.3-0.1-0.10.3
Right kidney weight2.77.69.4-2.9-3.13.0-3.02.9-3.0-2.8-2.9-2.8-2.6-2.5-0.6
Cocaine induced anxiety1.01.11.8-1.0-1.11.1-0.91.3-1.0-1.1-1.2-1.0-1.2-1.30.0
Post-drug Anxiety3.84.25.4-2.1-2.12.2-2.02.2-2.1-2.0-2.2-2.1-2.2-2.3-0.8
Baseline Anxiety1.11.21.6-1.2-1.21.1-1.20.9-1.3-1.1-1.0-1.3-1.0-0.8-0.3
Tail length0.00.10.30.20.2-0.30.40.20.40.0-0.30.30.10.3-0.6
Length with tail2.07.39.6-2.9-2.82.9-2.83.0-2.8-2.8-3.1-2.9-2.6-2.4-0.8
Length without tail6.714.620.1-4.0-4.24.3-4.53.9-4.2-3.8-3.7-4.4-3.4-3.4-0.4
Times rat made contact with spout0.10.10.3-0.1-0.30.3-0.5-0.1-0.1-0.20.3-0.00.40.40.1
Lifetime Intake1.51.72.11.41.3-1.51.4-1.31.31.41.31.31.31.4-0.1
Liver weight, left1.93.14.1-1.9-1.91.8-1.82.0-1.8-1.9-2.0-1.8-1.7-1.60.6
Liver weight, right1.93.24.3-1.9-1.91.8-1.82.0-2.0-2.0-2.1-1.7-1.7-1.50.4
Locomotor activity0.71.11.71.01.0-1.21.3-1.01.11.01.11.10.90.70.7
Locomotor testing distance2.13.44.81.91.9-2.12.2-1.82.01.82.12.01.71.60.6
Locomotor testing rearing1.62.55.11.71.8-2.02.3-1.21.81.51.61.71.31.10.1
Locomotion in novel chamber0.60.71.1-0.8-0.91.0-0.90.5-1.0-0.9-0.8-0.7-1.1-1.0-0.6
Locomotion in novel chamber post-restriction0.40.51.2-0.7-0.80.7-0.70.5-0.8-0.6-0.8-0.4-0.8-0.2-1.1
Fecal boli incidents, locomotor time 11.61.85.30.90.9-0.80.2-1.20.81.11.60.61.72.02.3
Change in fecal boli incidents, locomotor task0.90.91.5-1.0-0.90.9-0.70.7-0.8-0.8-1.1-0.8-1.1-1.2-1.0
Time >=10cm from walls, locomotor time 10.50.51.0-0.8-0.80.8-1.00.7-0.8-0.8-0.4-0.8-0.5-0.10.1
Bouts of movement, locomotor time 10.20.20.9-0.5-0.50.4-0.70.2-0.4-0.5-0.1-0.5-0.20.21.0
Total resting periods, locomotor time 10.10.21.00.00.1-0.1-0.1-0.30.20.10.30.00.40.71.0
Rest time, locomotor task time 10.10.10.50.20.3-0.2-0.0-0.50.30.40.40.20.40.7-0.3
Distance moved, locomotor task time 10.10.10.30.40.3-0.40.6-0.00.30.30.20.40.2-0.20.1
Vertical activity count, locomotor time 11.01.11.7-1.0-1.11.1-1.31.1-1.2-1.0-0.9-1.3-0.7-0.80.5
Time >=10cm from walls, locomotor time 20.30.30.60.50.6-0.50.4-0.80.50.60.50.50.50.60.5
Bouts of movement, locomotor time 22.72.94.0-1.9-1.91.8-1.61.7-1.9-1.8-1.8-1.4-2.0-1.9-0.0
Total resting periods, locomotor time 23.03.24.3-1.9-2.01.9-1.61.8-1.9-1.9-1.9-1.5-2.1-1.9-0.1
Rest time, locomotor task time 20.20.20.4-0.5-0.50.5-0.60.5-0.5-0.6-0.3-0.5-0.3-0.00.1
Distance moved, locomotor task time 20.30.40.60.70.7-0.60.7-0.70.70.80.50.70.50.20.0
Vertical activity count, locomotor time 20.20.20.4-0.3-0.50.4-0.40.4-0.5-0.3-0.6-0.2-0.4-0.3-0.3
Light reinforcement 12.13.87.72.22.1-2.42.8-1.42.32.01.22.21.41.41.2
Light reinforcement 20.81.01.91.11.0-1.11.1-1.01.11.00.80.90.80.71.4
Bone: marrow area6.514.017.1-3.8-4.14.0-3.84.1-3.9-3.9-4.0-3.7-3.7-3.9-0.7
Bone: maximum diameter4.48.110.3-3.1-3.23.0-2.93.2-3.0-2.9-3.1-2.7-2.7-2.7-0.4
Bone: maximum force12.120.926.0-5.1-4.84.8-4.75.0-4.7-5.0-4.9-4.8-4.2-4.31.1
Bone: maximum moment12.120.825.9-5.1-4.84.8-4.85.0-4.7-5.0-4.9-4.8-4.2-4.21.2
Mean time between licks in bursts0.30.50.70.70.8-0.80.8-0.70.70.80.60.70.50.40.7
Mean num. licks in bursts0.20.31.20.1-0.10.2-0.8-0.5-0.10.20.3-0.21.11.00.1
Cd content in liver0.20.30.30.50.6-0.50.5-0.50.60.60.40.50.60.5-0.2
Co content in liver0.30.43.80.10.4-0.40.4-0.20.30.10.20.10.10.01.9
Cu content in liver1.01.31.9-1.2-1.21.3-1.40.8-1.2-1.3-0.7-1.4-1.0-1.10.1
Fe content in liver0.10.10.30.30.3-0.30.3-0.20.20.20.30.20.30.30.5
K content in liver0.90.91.8-1.0-1.11.2-1.30.7-1.2-0.9-0.5-1.0-0.6-0.5-0.3
Mg content in liver0.00.00.1-0.1-0.10.2-0.3-0.2-0.10.00.1-0.2-0.00.1-0.1
Mn content in liver0.10.10.6-0.2-0.30.3-0.20.1-0.2-0.2-0.0-0.2-0.2-0.2-0.8
Na content in liver0.10.11.3-0.0-0.30.3-0.3-0.0-0.20.20.10.0-0.1-0.2-1.1
Rb content in liver0.00.00.10.00.1-0.20.2-0.3-0.00.20.20.2-0.00.10.2
Se content in liver0.30.40.70.60.6-0.60.4-0.70.70.70.70.50.80.8-0.1
Sr content in liver0.90.81.3-1.0-1.00.9-0.81.1-1.1-0.9-1.1-0.7-1.0-0.8-0.4
Zn content in liver0.70.81.31.00.7-0.80.9-0.90.70.90.81.10.60.8-1.1
Bone: minimum diameter7.914.817.5-4.1-4.03.9-3.64.2-3.9-4.1-4.1-4.0-4.0-4.10.6
Time in familiar zone, hab. session 10.40.40.90.60.4-0.40.2-0.90.40.70.80.40.90.9-0.6
Time in novel zone, hab. session 10.40.41.2-0.6-0.30.30.10.8-0.2-0.7-0.8-0.3-1.1-1.00.6
Total zone transitions, hab. session 10.20.30.60.50.7-0.70.7-0.50.80.40.50.60.50.50.4
Total locomotion distance, hab. session 10.10.10.80.10.3-0.20.1-0.20.40.20.30.00.20.20.9
Locomotion velocity, hab. session 10.00.10.70.10.2-0.10.1-0.10.30.00.2-0.10.10.00.8
Time in familiar zone, hab. session 20.20.31.8-0.4-0.20.3-0.40.3-0.3-0.4-0.4-0.5-0.00.01.4
Time in novel zone, hab. session 20.40.43.10.50.1-0.30.6-0.30.30.50.30.6-0.3-0.3-1.8
Total zone transitions, hab. session 20.20.20.70.40.3-0.30.1-0.70.40.30.60.30.80.90.0
Total locomotion distance, hab. session 20.20.30.50.40.4-0.40.1-0.70.50.50.70.20.70.70.6
Locomotion velocity, hab. session 20.10.10.30.20.2-0.1-0.1-0.50.20.30.50.00.50.60.5
Novel to familiar place preference ratio1.92.03.5-1.5-1.21.1-0.81.9-1.0-1.6-1.8-1.2-1.7-1.70.6
Novelty place preference1.41.42.8-1.3-1.00.8-0.51.7-0.7-1.4-1.6-0.9-1.5-1.50.7
Time in novel zone, NPP test1.21.22.5-1.2-0.80.7-0.31.6-0.6-1.2-1.6-0.8-1.5-1.50.6
Total zone transitions, NPP test1.11.62.71.21.3-1.10.8-1.61.21.21.61.01.51.60.4
Total locomotion distance, NPP test2.12.93.71.71.9-1.81.6-1.81.91.71.91.41.81.81.2
Locomotion velocity, NPP test1.21.72.41.21.4-1.31.0-1.51.41.21.51.01.41.41.2
Intraocular pressure8.211.416.23.63.9-3.94.0-3.53.73.43.23.42.92.91.0
Delta distance traveled before/after self-admin0.10.10.4-0.4-0.40.4-0.70.2-0.4-0.2-0.1-0.50.20.30.1
Delta ambulatory time before/after self-admin0.10.10.2-0.3-0.30.2-0.40.2-0.3-0.2-0.3-0.30.10.20.3
Parametrial fat weight1.32.64.31.61.3-1.51.2-1.81.41.91.71.71.92.1-0.6
Pavlov. Cond. lever latency0.10.22.00.1-0.20.1-0.0-0.0-0.10.20.10.20.00.0-1.4
Pavlov. Cond. magazine entry latency0.10.10.50.00.2-0.0-0.2-0.00.1-0.00.1-0.20.40.30.7
Pavlov. Cond. change in total contacts0.10.10.4-0.2-0.00.1-0.20.2-0.1-0.3-0.3-0.4-0.2-0.30.6
Pavlov. Cond. index score0.20.20.9-0.4-0.20.4-0.40.5-0.3-0.5-0.5-0.6-0.4-0.41.0
Pavlov. Cond. latency score0.20.31.7-0.4-0.10.3-0.30.4-0.2-0.5-0.4-0.5-0.3-0.31.3
Pavlov. Cond. lever contacts0.30.31.50.40.7-0.50.5-0.30.60.30.30.30.40.41.2
Pavlov. Cond. magazine entry number0.00.00.2-0.1-0.10.00.1-0.0-0.1-0.0-0.10.2-0.2-0.1-0.5
Pavlov. Cond. intertrial magazine entries0.60.71.60.90.7-0.70.6-1.30.70.81.30.60.81.00.0
Pavlov. Cond. lever-magazine prob. diff.0.50.60.9-0.7-0.60.7-0.80.7-0.7-0.9-0.7-0.9-0.6-0.60.9
Pavlov. Cond. response bias0.10.10.60.20.3-0.2-0.0-0.20.20.10.2-0.00.40.40.8
Pavlov. Cond. lever latency0.10.11.00.0-0.20.2-0.2-0.0-0.2-0.1-0.0-0.00.00.1-1.0
Pavlov. Cond. magazine entry latency0.60.71.1-1.0-0.60.7-0.61.0-0.6-0.9-1.0-0.9-0.8-1.00.9
Pavlov. Cond. change in total contacts1.41.92.9-1.5-1.11.2-1.21.4-1.2-1.4-1.5-1.5-1.1-1.41.7
Pavlov. Cond. index score0.40.61.5-0.8-0.40.5-0.40.8-0.4-0.7-0.9-0.7-0.7-0.81.2
Pavlov. Cond. latency score0.50.61.4-0.9-0.50.6-0.50.8-0.5-0.8-0.9-0.8-0.7-0.81.2
Pavlov. Cond. lever contacts0.20.31.50.30.6-0.60.5-0.20.60.40.30.30.30.31.2
Pavlov. Cond. magazine entry number1.92.33.11.71.3-1.31.1-1.61.21.61.71.61.61.8-1.4
Pavlov. Cond. intertrial magazine entries3.95.17.22.52.1-2.01.8-2.62.02.52.72.22.42.4-2.0
Pavlov. Cond. lever-magazine prob. diff.0.70.91.4-1.1-0.70.7-0.61.1-0.6-0.9-1.1-1.0-1.0-1.21.1
Pavlov. Cond. response bias0.10.21.60.00.4-0.40.40.00.40.2-0.00.10.1-0.11.3
Time in closed arm before self-admin1.31.52.7-1.1-1.11.1-0.71.3-1.1-1.3-1.5-1.0-1.5-1.7-1.1
Time in closed arm after self-admin0.50.50.6-0.8-0.60.7-0.60.7-0.6-0.8-0.7-0.7-0.8-0.70.3
Time in open arm before self-admin1.21.31.7-1.1-1.11.1-1.11.3-1.1-1.3-1.2-1.0-1.2-0.81.2
Time in open arm after self-admin0.20.20.40.50.5-0.50.6-0.60.50.50.50.60.40.3-0.3
Bone: periosteal estimation10.922.627.2-5.1-5.25.0-4.85.2-4.9-5.0-5.1-4.9-4.6-4.60.3
Bone: periosteal perimeter9.716.119.5-4.4-4.44.4-4.44.4-4.1-4.2-4.2-4.2-3.6-3.70.3
Bone: post-yield work7.19.711.6-3.3-3.33.3-3.03.4-3.3-3.2-3.3-3.0-3.2-3.3-1.4
Progressive ratio test 1 active lever presses2.72.94.31.81.8-2.02.1-1.61.91.71.61.81.51.60.3
Progressive ratio test 1 breakpoint2.42.53.91.71.7-1.92.0-1.51.71.61.51.71.31.50.3
Progressive ratio test 1 inactive lever presses2.22.43.31.81.7-1.71.8-1.41.71.51.41.81.31.6-0.7
Progressive ratio test 2 active lever presses1.31.42.51.31.2-1.41.6-1.01.31.20.91.40.91.10.7
Progressive ratio test 2 breakpoint1.82.03.41.51.5-1.71.9-1.21.61.51.11.71.11.30.7
Progressive ratio test 2 inactive lever presses2.22.63.91.91.7-1.82.0-1.51.71.71.41.91.31.40.2
Incentive Sensitization - Responses0.10.10.7-0.3-0.30.3-0.20.4-0.3-0.2-0.5-0.1-0.2-0.20.9
Incentive Sensitization - Breakpoint0.10.10.8-0.1-0.20.1-0.00.3-0.1-0.0-0.40.1-0.1-0.10.9
Sum of active levers in priming session hrs 5-60.20.20.30.50.5-0.40.4-0.40.50.50.50.40.30.4-0.5
Progressive ratio0.10.10.40.1-0.1-0.0-0.20.0-0.00.00.1-0.00.20.5-0.6
Food seeking constrained by brief footshock0.10.21.70.10.0-0.1-0.0-0.2-0.00.10.1-0.00.30.5-1.3
Seeking ratio, punishment vs. effort0.00.00.1-0.10.00.00.1-0.1-0.0-0.0-0.1-0.0-0.2-0.2-0.3
Retroperitoneal fat weight0.20.81.80.90.5-0.4-0.0-1.10.61.01.10.51.31.3-0.4
Reaction time number correct0.50.71.6-0.7-0.80.9-0.80.4-0.9-0.9-0.3-1.3-0.9-1.1-0.2
Reaction time mean minus median7.710.213.23.33.5-3.43.0-3.33.33.43.53.03.63.50.3
Reaction time mean minus median AUC5.67.39.72.82.9-2.92.6-2.72.82.92.92.43.12.90.4
Reaction time num false alarms1.92.63.21.71.6-1.61.5-1.61.71.81.71.51.71.7-1.0
Reaction time num false alarms AUC2.94.05.12.22.1-2.11.8-2.02.12.22.11.82.32.1-0.8
Reaction time trials correct on left0.50.71.6-0.7-0.80.9-0.80.4-0.9-0.9-0.3-1.3-0.9-1.1-0.2
Reaction time trials on left0.30.41.2-0.5-0.60.7-0.60.3-0.7-0.7-0.1-1.1-0.7-0.9-0.2
Reaction time mean0.50.70.90.70.9-1.00.8-0.80.90.90.90.40.90.80.7
Reaction time mean AUC0.30.40.60.50.7-0.70.5-0.60.70.80.80.20.80.60.7
Median of all reaction times0.10.10.3-0.3-0.10.0-0.10.3-0.1-0.2-0.2-0.5-0.2-0.20.5
Reaction time omissions9.012.314.83.73.8-3.73.5-3.73.83.73.83.33.63.6-0.0
Reaction time false alarm rate2.23.14.31.81.8-1.81.6-1.61.92.01.61.92.12.1-0.6
Reaction time premature initiation rate4.25.66.82.62.5-2.52.6-2.42.62.52.42.62.12.1-1.4
Reaction time premature initiations2.63.64.62.22.0-2.02.1-2.12.02.02.11.81.61.4-1.4
Std. dev. reaction times5.57.79.72.83.0-3.02.7-2.92.92.93.12.33.13.00.4
Reaction time trials completed0.30.41.2-0.5-0.60.7-0.60.3-0.7-0.7-0.1-1.1-0.7-0.9-0.2
Reaction time trials AUC0.71.02.0-0.9-1.01.0-1.00.6-1.1-1.1-0.4-1.4-1.1-1.3-0.3
Run reversals in cocaine runway, females0.10.10.30.40.4-0.40.6-0.20.50.30.10.30.1-0.10.2
Run reversals in cocaine runway, males1.31.21.71.21.3-1.11.1-1.11.31.10.91.21.10.9-1.0
Latency to leave start box in cocaine runway0.10.10.40.10.2-0.10.1-0.20.20.10.00.3-0.10.2-0.6
Latency to leave start box in cocaine runway, F1.61.82.91.41.5-1.51.6-1.21.51.31.11.71.01.2-0.7
Latency to leave start box in cocaine runway, M1.71.62.6-1.3-1.51.5-1.60.9-1.6-1.3-1.1-1.4-1.1-1.0-0.3
Std. dev. time between licks in bursts0.70.91.71.01.1-1.21.3-0.81.11.00.81.10.60.60.2
Total sessions with >9 infusions0.20.20.40.50.5-0.60.5-0.30.50.60.40.40.30.50.5
Short access day 1 total inactive lever presses0.70.81.21.00.9-1.01.0-0.81.01.10.81.10.81.0-0.2
Short access day 10 total inactive lever presses0.50.51.10.80.8-0.71.0-0.60.80.70.31.00.30.2-0.7
Short access day 1 total infusions0.00.10.1-0.2-0.30.2-0.30.3-0.3-0.1-0.2-0.3-0.30.00.0
Short access day 10 total infusions0.50.50.80.80.7-0.80.6-0.70.70.70.90.60.90.80.0
Short access total infusions0.10.10.10.30.3-0.40.3-0.20.30.30.30.20.30.4-0.2
Short access day 1 locomotion0.10.10.4-0.2-0.20.10.10.5-0.2-0.3-0.40.0-0.6-0.20.0
Short access day 10 total locomotion0.40.42.30.30.4-0.50.9-0.00.50.4-0.20.7-0.4-0.3-1.5
Short access total locomotion0.20.20.70.40.3-0.50.80.00.40.3-0.10.5-0.3-0.1-0.9
One hour access (0.3 mA shock)0.20.20.80.40.4-0.40.3-0.20.50.30.40.30.60.30.9
Compulsive drug intake0.60.60.8-0.9-0.80.8-0.90.8-0.8-0.8-0.8-0.9-0.5-0.70.6
One hour access (shock baseline)0.00.00.00.10.1-0.10.00.10.10.00.10.10.10.20.2
Social response proportion0.30.30.60.50.7-0.60.5-0.40.70.60.40.30.70.3-0.5
Social responses7.59.612.53.43.4-3.33.4-2.93.53.33.03.03.02.6-1.9
Social time0.40.63.40.30.8-0.70.4-0.30.70.50.40.00.80.71.8
Soleus weight0.82.33.5-1.3-1.81.7-1.51.5-1.5-1.3-1.7-1.1-1.4-1.3-1.9
Bone: stiffness14.723.227.9-5.2-5.15.1-5.05.3-5.1-5.2-5.2-5.0-4.5-4.50.9
Tibialis anterior weight2.06.79.2-2.4-3.02.8-2.52.9-2.8-2.6-3.0-2.1-2.6-2.6-1.3
Time to tail flick, vehicle, before self-admin1.11.11.61.11.2-1.11.0-1.01.20.91.21.01.31.20.4
Time to tail flick, vehicle, after self-admin0.20.20.9-0.3-0.30.20.20.6-0.2-0.4-0.6-0.1-0.8-1.00.1
Time to tail flick, test, before self-admin0.70.70.90.70.9-0.80.7-0.90.90.90.90.70.60.70.9
Time to tail flick, test, after self-admin0.10.10.2-0.2-0.40.4-0.40.3-0.4-0.3-0.2-0.2-0.3-0.2-0.1
Delta time to tail flick, vehicle, before/after SA0.40.40.8-0.7-0.60.6-0.40.6-0.6-0.5-0.7-0.5-0.8-0.9-0.4
Delta time to tail flick, test, before/after SA0.50.41.0-0.4-0.70.6-0.60.8-0.7-0.8-0.6-0.4-0.5-0.4-1.0
Tibia length6.718.824.7-4.7-4.44.3-4.04.9-4.4-4.7-5.0-4.5-4.4-4.40.7
Ambulatory time before self-admin3.33.45.22.12.0-2.12.3-1.92.01.91.62.21.51.5-0.3
Ambulatory time after self-admin1.31.42.11.21.2-1.31.5-1.21.31.20.91.51.01.0-0.5
Bone: tissue strength0.50.50.7-0.8-0.50.6-0.50.7-0.6-0.8-0.8-0.8-0.8-0.80.8
Total heroin consumption2.63.04.6-1.8-1.71.6-1.31.9-1.6-1.9-1.8-1.5-2.1-2.11.0
Bone: trabecular number4.67.29.9-3.0-2.52.7-3.22.8-2.6-3.0-2.7-3.1-1.8-1.72.4
Bone: trabecular spacing1.72.24.81.61.1-1.41.7-1.51.21.61.51.80.70.6-2.2
Bone: trabecular thickness0.40.54.2-0.00.6-0.50.2-0.00.50.10.00.00.70.62.1
Bone: trabecular tissue density0.10.10.40.20.4-0.40.7-0.10.50.20.10.4-0.1-0.20.5
Water consumed over 24 hours0.10.10.2-0.1-0.50.3-0.50.2-0.2-0.2-0.00.00.10.1-0.5
Number of responses in last shaping day0.50.51.1-0.7-0.70.6-0.41.1-0.6-0.7-1.0-0.4-0.9-0.80.3