Hub : Genes

Pfkm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Pfkm 0.1 0.06 2.4e-15 0.1 0.11 0.11 0.12 2.7e-11 4.7e-12 2.4e-12 1.1e-12
2 IL gene expression Pfkm 0.15 0.11 2.6e-03 0.12 0.12 0.11 0.11 1.0e-03 8.9e-04 1.2e-03 1.5e-03
3 Brain gene expression Pfkm 0.29 0.13 0.0e+00 0.34 0.36 0.35 0.36 3.7e-33 1.5e-34 5.3e-34 9.6e-35
4 BLA mRNA stability Pfkm 0.05 0.05 3.0e-03 0.08 0.05 0.07 0.07 5.9e-05 8.4e-04 1.0e-04 1.0e-04
5 Liver gene expression Pfkm 0.11 0.07 6.4e-14 0.11 0.11 0.11 0.11 2.8e-12 6.9e-12 5.2e-12 1.6e-12
6 Liver mRNA stability Pfkm 0.11 0.07 1.1e-11 0.09 0.09 0.09 0.09 1.4e-10 8.5e-10 2.6e-10 2.3e-10
7 pVTA gene expression Pfkm 0.11 0.07 3.5e-10 0.11 0.12 0.1 0.11 6.0e-09 7.2e-10 8.1e-09 3.7e-09
8 RMTg gene expression Pfkm 0.2 0.19 1.8e-03 0.05 0.06 0.03 0.04 1.8e-02 9.0e-03 5.9e-02 2.5e-02
9 LHb gene expression Pfkm 0.2 0.18 4.5e-03 0.03 0.03 -0.01 0.04 5.3e-02 5.9e-02 6.5e-01 3.6e-02
10 PL gene expression Pfkm 0.1 0.05 2.5e-15 0.13 0.14 0.13 0.13 7.0e-14 8.5e-15 2.2e-14 2.7e-14
11 Brain mRNA stability Pfkm 0.04 0.03 1.1e-05 0.06 0.05 0.05 0.05 7.0e-06 9.5e-06 3.0e-05 1.2e-05
12 Adipose gene expression Pfkm 0.03 0.02 3.4e-04 0.03 0.02 0.01 0.02 8.2e-04 1.6e-03 9.0e-03 3.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density8.315.316.5-3.93.83.94.0-4.04.13.73.94.03.73.9-3.9
Area under the delay curve0.81.21.8-1.41.21.20.8-1.31.11.11.01.01.10.8-1.1
BMI with tail7.225.027.0-5.05.15.25.0-5.25.14.94.95.04.94.9-5.0
BMI without tail1.47.28.6-2.92.72.72.7-2.72.62.62.52.72.62.8-2.8
Body weight7.834.035.8-5.95.96.05.9-5.95.85.75.76.05.75.7-5.8
Weight adjusted by age1.54.35.0-1.82.12.12.2-1.92.12.22.22.12.22.1-2.1
Bone surface9.919.520.4-4.44.44.44.5-4.54.54.34.44.54.34.4-4.4
Bone volume7.214.415.6-3.83.73.83.9-3.93.93.73.83.83.73.7-3.8
Breakpoint value in progressive ratio session0.71.21.7-1.31.11.11.1-1.01.01.11.21.01.11.3-1.0
Number of licking bursts0.00.10.20.3-0.5-0.4-0.30.5-0.2-0.2-0.2-0.0-0.2-0.0-0.0
Context. condit. distance diff. score0.50.61.0-0.70.70.80.7-0.80.60.70.70.80.71.0-0.7
Locomotion velocity, session 10.91.01.90.9-0.8-0.8-1.11.0-1.1-0.8-1.0-1.4-0.8-1.31.1
Locomotion distance, session 13.24.25.72.1-1.8-1.9-1.91.9-2.0-2.0-2.0-2.4-2.0-2.32.2
Locomotion velocity, session 20.50.61.50.7-0.5-0.5-0.60.6-0.7-0.6-0.6-1.2-0.7-1.01.0
Locomotion distance, session 22.94.15.62.0-1.8-2.0-1.91.9-1.9-1.9-2.0-2.4-2.0-2.32.2
Locomotion velocity, session 33.94.56.02.1-2.0-2.1-2.12.0-2.1-2.1-2.1-2.2-2.1-2.52.2
Locomotion distance, session 35.05.76.62.5-2.4-2.4-2.32.3-2.3-2.4-2.4-2.3-2.4-2.62.4
Stereotopy head waving bouts, day 30.91.11.4-1.01.01.01.2-1.01.11.11.20.81.10.7-1.0
Stereotopy head waving duration, day 30.30.30.5-0.50.60.60.7-0.60.70.70.70.20.70.3-0.4
Locomotion velocity, session 70.00.00.10.2-0.1-0.1-0.30.1-0.1-0.1-0.2-0.0-0.1-0.0-0.1
Locomotion distance, session 70.81.01.41.0-1.2-1.1-1.21.2-1.1-1.1-1.1-0.7-1.1-0.70.7
Stereotopy head waving bouts, day 71.31.52.0-1.01.21.21.4-1.11.11.41.41.11.41.3-0.9
Stereotopy head waving duration, day 71.01.31.7-1.01.21.21.2-1.11.01.31.21.01.31.1-0.8
Locomotion velocity, session 80.00.00.1-0.20.30.30.2-0.20.10.20.2-0.20.2-0.10.1
Locomotion distance, session 81.31.82.21.4-1.2-1.3-1.31.2-1.4-1.4-1.4-1.4-1.4-1.31.5
Degree of sensitization distance0.91.01.8-1.10.90.90.8-0.90.91.00.91.11.01.3-1.1
Degree of sensitization stereotypy0.30.30.5-0.40.60.50.6-0.40.40.70.60.40.70.7-0.2
Conditioned locomotion0.00.00.1-0.3-0.10.00.20.10.10.20.2-0.10.3-0.2-0.1
Cocaine response after cond. corrected0.00.00.10.00.30.1-0.0-0.20.0-0.1-0.2-0.2-0.2-0.30.3
Cocaine response after cond. not corrected0.71.01.41.2-0.9-0.9-0.90.8-1.0-1.1-1.0-1.1-1.1-1.01.2
Cocaine response before conditioning5.36.48.42.9-2.9-2.7-2.52.8-2.6-2.6-2.4-2.3-2.5-1.92.1
Saline control response0.00.00.10.1-0.3-0.3-0.10.3-0.2-0.3-0.10.0-0.30.10.1
Bone: connectivity density5.79.19.9-3.13.03.03.0-3.13.12.93.03.02.93.0-3.0
Bone: cortical apparent density0.20.40.60.5-0.8-0.7-0.70.7-0.6-0.6-0.6-0.6-0.6-0.40.6
Bone: cortical area11.418.519.5-4.44.34.34.4-4.34.44.34.34.34.34.2-4.1
Bone: cortical porosity1.71.92.51.6-1.5-1.5-1.31.4-1.3-1.4-1.3-1.3-1.3-1.31.3
Bone: cortical porosity1.92.12.71.6-1.6-1.6-1.41.6-1.4-1.4-1.4-1.3-1.4-1.31.4
Bone: cortical thickness5.28.79.9-3.02.93.03.1-3.03.13.03.02.83.02.7-2.8
Bone: cortical thickness0.40.50.6-0.70.70.70.8-0.60.80.70.70.80.70.8-0.6
Bone: cortical tissue density0.30.50.80.6-0.9-0.8-0.80.8-0.7-0.7-0.7-0.7-0.7-0.50.7
Condit. Reinf. active minus inactive responses0.20.20.50.4-0.3-0.3-0.30.3-0.3-0.4-0.4-0.6-0.4-0.60.7
Condit. Reinf. active-inactive response ratio0.10.10.2-0.40.40.40.4-0.40.30.30.30.10.20.10.1
Condit. Reinf. active responses0.71.01.71.0-0.8-0.9-0.80.8-0.8-0.9-0.9-1.3-0.9-1.21.2
Condit. Reinf. inactive responses2.63.44.02.0-1.8-1.9-1.81.8-1.8-1.8-1.8-2.0-1.8-1.81.7
Incentive salience index mean0.00.00.1-0.10.20.20.3-0.20.20.10.2-0.00.1-0.10.1
Condit. Reinf. lever presses0.20.40.6-0.50.60.60.8-0.70.70.60.70.40.60.2-0.5
Condit. Reinf. active minus inactive responses0.00.00.10.1-0.2-0.2-0.30.3-0.2-0.1-0.20.0-0.10.00.0
Condit. Reinf. active-inactive response ratio0.20.30.40.6-0.5-0.6-0.60.6-0.5-0.5-0.6-0.6-0.5-0.60.5
Condit. Reinf. active responses0.20.30.50.6-0.6-0.7-0.70.7-0.6-0.6-0.6-0.2-0.6-0.20.4
Condit. Reinf. inactive responses0.60.81.21.1-1.1-1.0-1.01.1-1.0-0.9-0.9-0.6-0.9-0.40.8
Condit. Reinf. lever presses0.00.00.2-0.10.00.00.1-0.00.00.00.00.4-0.00.5-0.1
Condit. Reinf. lever reinforcers received0.50.70.90.9-0.9-0.9-0.91.0-0.9-0.9-0.9-0.5-0.8-0.40.7
Conditioned reinforcement - actives0.20.81.21.0-1.0-0.9-0.90.9-0.9-0.9-1.0-0.6-0.9-1.10.8
Conditioned reinforcement - inactives1.54.04.91.9-2.0-1.9-2.11.9-2.0-2.0-2.1-1.9-2.0-2.22.0
Conditioned locomotion0.10.10.30.3-0.5-0.4-0.40.5-0.4-0.3-0.4-0.0-0.3-0.20.3
Patch foraging indifference point 0 sec1.02.83.91.6-1.6-1.5-2.01.6-1.8-1.8-1.8-1.6-1.8-1.61.3
Patch foraging indifference point AUC0.51.21.71.1-1.1-1.2-1.31.1-1.2-1.0-1.1-1.0-1.0-0.91.1
Delay disc. indifference point, 0s delay1.31.51.9-1.41.31.31.0-1.31.31.31.21.11.30.8-1.0
Delay disc. indifference point, 16s delay1.01.41.8-1.41.21.20.9-1.31.11.21.11.21.21.0-1.3
Delay disc. indifference point, 2s delay0.91.01.1-0.91.01.11.0-1.01.01.01.10.91.00.9-0.8
Delay disc. indifference point, 24s delay0.91.41.8-1.21.21.20.9-1.21.11.21.11.21.21.1-1.3
Delay disc. indifference point, 4s delay0.40.50.8-0.90.80.70.6-0.90.70.60.50.70.60.5-0.7
Delay disc. indifference point, 8s delay1.83.04.0-2.01.91.91.4-2.01.71.71.71.61.71.4-1.6
Indifference point function ln k1.75.15.7-2.32.22.32.2-2.22.22.32.32.12.32.2-2.4
Indifference point function log k1.75.15.7-2.32.22.32.2-2.22.22.32.32.12.32.2-2.4
Patch foraging total patch changes 0 sec0.92.83.81.6-1.7-1.5-1.91.6-1.8-1.7-1.8-1.5-1.7-1.51.3
Patch foraging total patch changes 12 sec1.82.43.01.5-1.5-1.5-1.71.6-1.7-1.5-1.6-1.5-1.5-1.51.5
Patch foraging total patch changes 18 sec2.25.17.32.2-2.3-2.3-2.72.3-2.3-2.3-2.4-2.0-2.2-2.12.0
Patch foraging total patch changes 24 sec0.61.92.51.3-1.4-1.4-1.61.4-1.5-1.3-1.5-1.2-1.3-1.41.1
Patch foraging total patch changes 6 sec2.23.84.12.0-2.0-1.9-2.02.0-2.0-2.0-2.0-1.8-2.0-1.71.8
Patch foraging time to switch 0 sec1.14.45.32.3-2.2-2.3-1.82.3-2.1-2.1-2.0-2.0-2.1-1.92.1
Patch foraging water rate 0 sec1.86.78.4-2.92.72.82.3-2.82.62.62.52.42.62.2-2.5
Patch foraging water rate 12 sec1.35.45.9-2.42.32.32.2-2.22.32.42.42.42.42.4-2.3
Patch foraging water rate 18 sec0.41.01.4-1.01.00.90.9-0.90.81.00.91.21.01.0-1.1
Patch foraging water rate 24 sec3.04.24.8-2.12.12.12.0-2.02.02.22.11.92.22.0-2.0
Patch foraging water rate 6 sec4.87.07.8-2.72.72.62.7-2.62.62.72.62.62.72.4-2.8
Seeking ratio, delayed vs. immediate footshock0.10.10.3-0.20.50.50.3-0.60.50.20.20.10.20.0-0.1
Distance traveled before self-admin0.30.70.90.9-0.9-0.9-0.70.9-0.8-0.7-0.8-0.8-0.7-0.80.8
Distance traveled after self-admin0.20.30.50.4-0.5-0.5-0.50.4-0.4-0.6-0.6-0.6-0.6-0.70.5
Extensor digitorum longus weight5.521.924.1-4.84.94.64.5-4.54.64.84.64.84.84.6-4.5
Bone: elastic displacement4.86.06.62.4-2.5-2.5-2.52.5-2.4-2.4-2.4-2.5-2.4-2.52.6
Bone: elastic work0.10.10.20.2-0.3-0.3-0.20.3-0.1-0.2-0.2-0.2-0.2-0.40.4
Bone: endosteal estimation6.716.517.6-4.24.14.04.0-3.93.94.14.14.14.14.2-4.0
Bone: endosteal perimeter6.516.018.4-4.04.03.94.1-3.83.94.04.04.14.04.3-3.8
Epididymis fat weight0.63.24.1-1.92.01.91.5-1.91.81.81.61.71.81.3-1.8
Delta time in closed arm before/after self-admin0.10.10.10.3-0.2-0.2-0.20.2-0.2-0.3-0.3-0.2-0.4-0.20.1
Delta time in open arm before/after self-admin0.70.81.10.8-0.9-0.9-1.01.0-0.9-0.8-0.8-1.1-0.8-0.91.0
Diff in mean of infusions in LGA sessions0.40.81.6-0.80.90.91.3-1.00.70.91.00.70.90.8-0.7
Delay discount exponential model param0.81.11.61.3-1.1-1.1-0.71.2-1.0-1.0-0.9-1.0-1.0-0.81.0
Extinction: sum of active levers before priming1.01.41.7-1.31.21.21.2-1.21.11.31.31.11.31.0-1.1
Active lever presses in extinction session 61.21.21.5-1.21.11.21.0-1.11.01.01.10.91.01.1-1.2
Bone: final force10.316.917.9-4.24.24.24.2-4.24.24.14.13.94.13.7-4.0
Bone: final moment10.817.518.6-4.34.34.34.3-4.34.34.24.24.04.23.8-4.1
Food consumed during 24 hour testing period0.81.62.0-1.21.31.31.3-1.31.31.21.21.31.11.4-1.1
Glucose0.40.61.0-0.80.60.60.7-0.60.80.70.80.90.71.0-0.8
Heart weight0.10.10.2-0.40.40.30.2-0.30.40.30.30.30.30.4-0.2
Delay discount hyperbolic model param0.70.91.41.2-1.1-1.1-0.61.2-1.0-0.9-0.9-0.9-0.9-0.70.9
Intermittent access intake day 1-15 change0.00.00.0-0.1-0.00.0-0.00.0-0.0-0.1-0.10.1-0.2-0.00.1
Intermittent access intake escalation0.00.10.2-0.30.30.30.2-0.30.30.20.10.40.10.2-0.2
Intermittent access intake escalation 20.00.00.10.1-0.1-0.0-0.10.1-0.1-0.2-0.2-0.0-0.2-0.10.2
Intermitt. access day 1 inactive lever presses0.11.62.41.3-1.5-1.4-1.41.5-1.4-1.2-1.2-1.1-1.1-0.91.2
Intermitt. access day 15 inactive lever presses0.21.31.71.1-1.2-1.2-1.31.1-1.2-1.2-1.2-1.1-1.2-1.11.0
Intermitt. access escalation Index0.30.81.2-0.80.80.90.8-0.80.90.90.91.00.91.1-1.1
Intermittent access day 1 total infusions0.41.11.31.1-1.0-0.9-0.90.9-1.1-1.1-1.1-1.1-1.1-1.11.0
Intermittent access day 15 total infusions0.20.40.50.7-0.7-0.5-0.60.5-0.6-0.7-0.7-0.5-0.7-0.70.5
Intermittent access terminal intake (last 3 days)0.50.91.11.0-1.0-0.9-0.90.9-1.0-1.0-1.1-0.8-1.0-1.00.8
Intermittent access total infusions0.91.11.31.1-1.1-1.0-1.01.0-1.1-1.1-1.1-1.0-1.1-1.11.0
Intermittent access day 1 locomotion0.00.00.10.3-0.2-0.1-0.30.2-0.2-0.1-0.20.1-0.1-0.1-0.0
Intermittent access day 15 total locomotion0.00.00.20.2-0.2-0.2-0.20.2-0.1-0.1-0.10.4-0.00.1-0.1
Intermittent access total locomotion0.50.60.80.8-0.9-0.8-0.90.8-0.8-0.7-0.9-0.3-0.7-0.70.5
Intermittent access standard deviation0.00.20.50.4-0.4-0.3-0.30.4-0.5-0.5-0.5-0.7-0.5-0.40.6
Left kidney weight0.64.86.9-2.32.52.52.1-2.62.32.12.01.92.01.7-2.1
Right kidney weight3.121.925.4-4.84.94.94.6-5.04.74.74.54.44.64.2-4.7
Cocaine induced anxiety1.54.25.2-1.92.02.02.2-1.92.02.12.12.12.12.3-1.9
Post-drug Anxiety3.23.64.2-2.11.91.91.9-1.91.91.91.91.91.91.9-1.8
Baseline Anxiety0.10.10.6-0.80.30.40.1-0.50.40.20.20.10.2-0.2-0.4
Tail length0.00.20.4-0.60.40.30.4-0.30.20.30.30.50.30.6-0.6
Length with tail1.98.58.9-3.03.03.03.0-2.92.82.92.93.02.92.8-3.0
Length without tail3.820.123.0-4.54.84.84.4-4.84.54.54.44.54.44.0-4.3
Times rat made contact with spout0.00.00.1-0.10.30.1-0.0-0.10.10.0-0.0-0.10.0-0.30.1
Lifetime Intake1.11.31.61.2-1.2-1.1-1.11.0-1.2-1.2-1.2-1.1-1.2-1.31.1
Liver weight, left9.616.517.8-4.13.94.14.2-4.14.14.04.14.14.04.2-3.9
Liver weight, right2.84.95.6-2.32.22.32.0-2.32.22.22.12.42.22.1-2.3
Locomotor activity0.91.42.01.4-1.3-1.1-1.01.2-1.2-1.2-1.2-1.2-1.1-1.21.1
Locomotor testing distance1.53.74.22.1-2.1-1.9-1.92.0-1.9-1.9-2.0-1.9-1.9-1.91.8
Locomotor testing rearing0.93.24.11.9-2.0-1.8-1.92.0-1.9-1.8-1.8-1.5-1.8-1.41.5
Locomotion in novel chamber1.41.92.3-1.31.51.51.4-1.31.31.51.41.41.51.3-1.4
Locomotion in novel chamber post-restriction0.00.10.1-0.10.30.3-0.1-0.40.30.20.10.20.2-0.3-0.2
Fecal boli incidents, locomotor time 10.41.22.50.7-0.8-0.9-0.90.7-1.0-1.2-1.2-1.2-1.2-1.61.1
Change in fecal boli incidents, locomotor task0.40.40.6-0.70.70.70.8-0.60.60.70.70.50.80.5-0.6
Time >=10cm from walls, locomotor time 10.30.30.9-0.90.60.60.3-0.70.70.40.40.60.40.2-0.7
Bouts of movement, locomotor time 10.10.10.3-0.30.40.40.4-0.50.50.30.30.20.3-0.3-0.4
Total resting periods, locomotor time 10.10.10.70.2-0.2-0.2-0.10.1-0.1-0.3-0.3-0.4-0.3-0.80.2
Rest time, locomotor task time 10.10.10.60.1-0.2-0.3-0.30.2-0.2-0.3-0.3-0.4-0.4-0.80.4
Distance moved, locomotor task time 10.00.10.30.5-0.4-0.30.10.4-0.4-0.3-0.2-0.0-0.20.40.2
Vertical activity count, locomotor time 10.21.41.9-1.21.21.21.2-1.21.21.11.11.11.11.4-1.1
Time >=10cm from walls, locomotor time 20.20.51.20.5-0.6-0.5-0.70.5-0.6-0.6-0.7-0.9-0.6-1.10.6
Bouts of movement, locomotor time 21.13.84.8-2.01.92.02.2-2.01.82.02.01.72.01.6-1.9
Total resting periods, locomotor time 21.04.15.1-2.02.02.02.3-2.01.92.12.11.92.11.7-2.1
Rest time, locomotor task time 20.10.20.4-0.60.40.40.5-0.40.50.30.30.50.30.2-0.5
Distance moved, locomotor task time 20.30.40.70.9-0.6-0.6-0.30.7-0.6-0.6-0.6-0.6-0.6-0.40.8
Vertical activity count, locomotor time 20.10.20.4-0.60.50.40.0-0.50.40.50.40.50.50.5-0.4
Light reinforcement 11.04.76.32.1-2.5-2.5-2.12.5-2.3-2.2-2.2-1.6-2.1-1.72.0
Light reinforcement 20.40.91.30.9-1.1-1.1-0.61.1-1.0-1.0-0.9-0.8-1.0-0.91.1
Bone: marrow area6.616.217.4-4.24.14.04.0-3.83.94.14.04.14.14.2-3.9
Bone: maximum diameter4.79.510.3-3.23.23.13.1-3.03.03.23.13.13.13.1-2.8
Bone: maximum force12.925.426.3-5.15.05.15.1-5.05.15.05.15.15.04.9-5.0
Bone: maximum moment13.525.626.5-5.15.15.15.1-5.15.15.05.15.15.04.9-5.0
Mean time between licks in bursts0.10.60.80.9-0.9-0.7-0.70.7-0.7-0.8-0.7-0.9-0.8-0.90.8
Mean num. licks in bursts0.00.10.40.10.2-0.0-0.1-0.1-0.1-0.2-0.3-0.5-0.3-0.60.5
Cd content in liver0.60.70.90.9-0.8-0.8-0.90.7-0.8-0.9-0.9-0.8-0.9-0.80.7
Co content in liver0.00.00.1-0.1-0.10.10.1-0.20.2-0.00.10.20.00.1-0.3
Cu content in liver1.82.22.7-1.51.71.61.6-1.71.51.51.50.91.50.9-1.5
Fe content in liver1.51.92.61.5-1.3-1.2-1.31.3-1.4-1.3-1.3-1.6-1.3-1.61.4
K content in liver0.40.40.7-0.70.90.80.5-0.70.60.70.60.40.70.3-0.6
Mg content in liver0.00.00.20.10.0-0.1-0.20.1-0.1-0.1-0.1-0.3-0.1-0.40.2
Mn content in liver0.00.00.1-0.00.0-0.1-0.30.1-0.10.0-0.1-0.20.1-0.4-0.2
Na content in liver0.00.00.1-0.20.20.10.0-0.00.10.30.20.00.30.2-0.0
Rb content in liver0.10.10.2-0.30.40.50.5-0.40.40.40.40.20.4-0.1-0.4
Se content in liver1.01.21.71.1-1.0-1.1-1.21.0-1.1-1.1-1.1-1.1-1.1-1.30.8
Sr content in liver2.52.23.0-1.61.41.41.3-1.51.41.41.41.71.41.6-1.5
Zn content in liver0.40.40.60.6-0.5-0.6-0.80.7-0.7-0.6-0.7-0.7-0.6-0.70.7
Bone: minimum diameter9.217.618.8-4.24.14.14.2-4.14.24.24.34.24.24.3-4.2
Time in familiar zone, hab. session 10.40.40.90.5-0.4-0.5-0.60.5-0.6-0.6-0.6-0.9-0.6-0.90.8
Time in novel zone, hab. session 10.30.30.7-0.30.30.40.5-0.40.60.50.60.80.60.8-0.6
Total zone transitions, hab. session 10.30.40.60.7-0.7-0.7-0.60.7-0.6-0.6-0.6-0.8-0.6-0.70.6
Total locomotion distance, hab. session 10.00.00.10.3-0.2-0.2-0.00.2-0.1-0.2-0.1-0.2-0.2-0.20.1
Locomotion velocity, hab. session 10.00.00.00.1-0.1-0.10.10.10.0-0.1-0.0-0.1-0.1-0.0-0.0
Time in familiar zone, hab. session 20.10.10.2-0.40.30.40.4-0.40.50.20.30.20.20.1-0.2
Time in novel zone, hab. session 20.10.10.30.3-0.3-0.4-0.40.5-0.5-0.2-0.3-0.1-0.10.10.1
Total zone transitions, hab. session 20.20.30.70.4-0.3-0.4-0.40.3-0.4-0.5-0.5-0.8-0.5-0.90.6
Total locomotion distance, hab. session 20.20.20.50.4-0.4-0.4-0.40.4-0.4-0.5-0.5-0.7-0.5-0.70.5
Locomotion velocity, hab. session 20.10.10.30.1-0.1-0.2-0.20.1-0.2-0.2-0.3-0.5-0.3-0.60.3
Novel to familiar place preference ratio1.62.13.8-1.21.21.21.4-1.11.31.41.51.81.42.0-1.8
Novelty place preference1.21.53.1-0.90.90.91.2-0.91.11.11.21.61.21.8-1.6
Time in novel zone, NPP test1.01.22.9-0.80.70.71.0-0.71.01.01.11.51.11.7-1.5
Total zone transitions, NPP test1.11.72.91.1-1.1-1.2-1.11.1-1.1-1.3-1.2-1.6-1.3-1.71.5
Total locomotion distance, NPP test2.02.83.31.6-1.7-1.7-1.51.6-1.5-1.7-1.6-1.8-1.7-1.81.7
Locomotion velocity, NPP test1.11.52.11.2-1.2-1.2-1.01.1-1.1-1.3-1.2-1.4-1.3-1.41.2
Intraocular pressure7.311.914.53.6-3.8-3.6-3.33.6-3.4-3.5-3.3-3.3-3.5-3.23.2
Delta distance traveled before/after self-admin0.00.00.1-0.30.10.0-0.1-0.20.1-0.1-0.1-0.2-0.1-0.20.1
Delta ambulatory time before/after self-admin0.00.00.1-0.1-0.1-0.1-0.1-0.1-0.0-0.2-0.2-0.2-0.2-0.20.1
Parametrial fat weight0.51.21.90.9-0.9-1.0-1.10.9-1.1-1.1-1.2-1.1-1.1-1.41.1
Pavlov. Cond. lever latency0.00.00.10.10.1-0.1-0.20.2-0.10.0-0.1-0.00.0-0.10.2
Pavlov. Cond. magazine entry latency0.00.00.10.0-0.2-0.2-0.1-0.0-0.2-0.3-0.2-0.1-0.3-0.1-0.1
Pavlov. Cond. change in total contacts0.10.10.3-0.30.20.30.5-0.30.30.20.30.20.20.5-0.4
Pavlov. Cond. index score0.30.30.6-0.60.40.50.7-0.70.60.40.50.60.40.6-0.7
Pavlov. Cond. latency score0.20.30.5-0.60.30.50.6-0.60.50.40.40.50.40.5-0.7
Pavlov. Cond. lever contacts0.10.10.30.3-0.5-0.4-0.20.3-0.3-0.4-0.3-0.3-0.4-0.10.2
Pavlov. Cond. magazine entry number0.00.00.10.3-0.1-0.2-0.20.3-0.1-0.0-0.1-0.2-0.0-0.20.3
Pavlov. Cond. intertrial magazine entries0.70.81.60.9-0.7-0.7-0.70.8-0.8-0.8-0.8-1.3-0.8-1.31.0
Pavlov. Cond. lever-magazine prob. diff.0.50.70.9-0.90.70.80.9-0.90.80.70.70.80.70.8-0.9
Pavlov. Cond. response bias0.00.00.10.1-0.3-0.2-0.10.1-0.2-0.3-0.3-0.2-0.3-0.10.2
Pavlov. Cond. lever latency0.10.10.2-0.30.40.30.2-0.30.20.40.30.10.40.1-0.4
Pavlov. Cond. magazine entry latency0.60.81.3-0.90.70.81.0-0.80.90.80.91.00.81.2-0.9
Pavlov. Cond. change in total contacts1.12.63.8-1.61.41.61.7-1.61.71.51.71.81.42.0-1.6
Pavlov. Cond. index score0.50.81.3-0.90.70.81.0-0.80.90.80.91.10.81.2-0.8
Pavlov. Cond. latency score0.40.71.1-0.80.60.80.9-0.80.90.70.91.00.71.0-0.8
Pavlov. Cond. lever contacts0.00.00.10.0-0.2-0.1-0.00.10.0-0.2-0.10.1-0.20.10.1
Pavlov. Cond. magazine entry number2.22.83.71.6-1.4-1.6-1.81.6-1.7-1.6-1.7-1.8-1.6-1.91.7
Pavlov. Cond. intertrial magazine entries3.57.69.82.7-2.4-2.6-2.92.5-2.8-2.7-2.8-3.0-2.7-3.12.9
Pavlov. Cond. lever-magazine prob. diff.0.71.01.8-1.00.80.91.1-0.91.10.91.11.20.91.3-1.0
Pavlov. Cond. response bias0.10.10.2-0.20.00.10.3-0.20.30.10.30.40.10.5-0.1
Time in closed arm before self-admin1.62.73.9-1.71.51.51.6-1.61.41.71.71.71.72.0-1.7
Time in closed arm after self-admin0.10.10.2-0.40.20.20.1-0.30.10.20.20.40.20.4-0.3
Time in open arm before self-admin0.00.00.10.2-0.0-0.00.10.10.1-0.0-0.10.3-0.0-0.0-0.2
Time in open arm after self-admin0.00.00.10.4-0.1-0.1-0.10.20.1-0.1-0.1-0.3-0.1-0.10.2
Bone: periosteal estimation11.928.229.8-5.55.45.35.4-5.25.35.35.35.35.35.3-5.1
Bone: periosteal perimeter10.119.921.7-4.64.74.54.6-4.54.54.54.54.44.44.4-4.2
Bone: post-yield work7.012.013.2-3.63.53.43.4-3.33.33.53.43.53.53.6-3.4
Progressive ratio test 1 active lever presses2.34.04.82.1-2.2-2.1-2.12.1-2.0-2.0-2.1-1.7-2.0-2.01.8
Progressive ratio test 1 breakpoint2.13.64.31.9-2.1-1.9-2.01.9-1.9-1.9-2.0-1.6-1.9-1.81.6
Progressive ratio test 1 inactive lever presses0.61.52.11.3-1.3-1.3-1.41.3-1.2-1.2-1.3-1.0-1.2-1.31.1
Progressive ratio test 2 active lever presses0.71.01.31.2-1.1-1.0-0.91.0-1.0-1.0-1.0-0.7-0.9-1.00.8
Progressive ratio test 2 breakpoint0.70.91.21.1-1.1-1.0-0.91.0-0.9-0.9-1.0-0.6-0.9-0.90.8
Progressive ratio test 2 inactive lever presses0.41.21.61.3-1.2-1.1-1.01.2-1.1-1.1-1.1-0.9-1.0-1.01.0
Incentive Sensitization - Responses0.20.50.8-0.60.70.70.9-0.70.70.70.70.90.70.5-0.7
Incentive Sensitization - Breakpoint0.20.40.6-0.50.60.60.8-0.60.60.60.60.80.60.4-0.6
Sum of active levers in priming session hrs 5-60.00.00.10.2-0.2-0.2-0.30.2-0.1-0.1-0.1-0.1-0.20.10.1
Progressive ratio0.10.20.40.4-0.4-0.5-0.60.4-0.5-0.5-0.6-0.3-0.5-0.40.3
Food seeking constrained by brief footshock0.20.30.60.3-0.4-0.5-0.80.3-0.4-0.5-0.6-0.6-0.5-0.80.4
Seeking ratio, punishment vs. effort0.00.00.1-0.00.00.0-0.0-0.00.10.10.1-0.30.1-0.20.1
Retroperitoneal fat weight0.20.82.70.7-0.5-0.7-0.80.6-0.8-0.7-0.9-1.2-0.8-1.60.9
Reaction time number correct0.20.81.3-1.00.90.91.1-0.80.90.91.00.60.90.9-0.9
Reaction time mean minus median1.811.813.43.7-3.5-3.4-3.33.3-3.4-3.6-3.5-3.4-3.6-3.23.3
Reaction time mean minus median AUC1.28.39.73.1-2.9-2.8-2.82.8-2.9-3.0-3.0-2.7-3.0-2.72.6
Reaction time num false alarms1.62.83.21.8-1.5-1.6-1.71.6-1.7-1.7-1.7-1.7-1.7-1.51.8
Reaction time num false alarms AUC1.94.35.12.3-1.9-2.0-2.12.0-2.1-2.1-2.1-2.1-2.1-1.82.2
Reaction time trials correct on left0.20.81.3-1.00.90.91.1-0.80.90.91.00.60.90.9-0.9
Reaction time trials on left0.20.50.9-0.80.70.71.0-0.60.70.70.80.40.70.7-0.8
Reaction time mean0.40.81.21.1-1.0-0.9-0.80.9-0.7-0.9-0.8-0.7-1.0-0.80.9
Reaction time mean AUC0.20.40.80.9-0.7-0.6-0.50.6-0.4-0.7-0.6-0.5-0.7-0.60.7
Median of all reaction times0.00.10.2-0.00.10.20.3-0.20.50.20.30.40.20.3-0.1
Reaction time omissions9.114.815.53.9-3.8-3.8-3.83.8-3.8-3.9-3.8-3.9-3.9-3.93.9
Reaction time false alarm rate2.53.54.22.1-1.7-1.8-2.01.7-1.9-1.9-1.9-1.8-1.9-1.72.0
Reaction time premature initiation rate3.75.86.72.3-2.4-2.5-2.52.6-2.4-2.3-2.4-2.3-2.3-2.22.5
Reaction time premature initiations1.13.44.31.7-1.8-2.0-1.82.1-1.9-1.8-1.8-1.9-1.8-1.72.0
Std. dev. reaction times2.79.110.93.3-3.1-3.0-2.92.9-2.9-3.1-3.0-2.9-3.1-2.92.9
Reaction time trials completed0.20.50.9-0.80.70.71.0-0.60.70.70.80.40.70.7-0.8
Reaction time trials AUC0.31.21.6-1.21.01.11.3-1.01.11.11.20.81.11.0-1.1
Run reversals in cocaine runway, females0.10.10.20.5-0.4-0.40.00.5-0.2-0.2-0.1-0.2-0.20.20.3
Run reversals in cocaine runway, males1.01.21.81.0-1.0-1.0-1.31.1-1.1-1.0-1.0-1.1-1.0-1.11.0
Latency to leave start box in cocaine runway0.00.10.20.4-0.2-0.3-0.30.3-0.1-0.2-0.1-0.1-0.2-0.10.3
Latency to leave start box in cocaine runway, F1.01.31.91.4-1.2-1.3-1.31.3-1.0-1.1-1.0-0.9-1.0-0.91.1
Latency to leave start box in cocaine runway, M1.71.61.9-1.31.41.31.3-1.31.21.31.21.21.21.2-1.1
Std. dev. time between licks in bursts0.50.91.30.9-1.1-1.0-1.01.1-0.9-1.0-0.9-0.9-1.0-0.90.9
Total sessions with >9 infusions0.60.81.41.0-0.8-0.8-0.90.7-0.8-0.9-1.0-0.6-0.9-1.20.8
Short access day 1 total inactive lever presses0.71.42.01.2-1.2-1.2-1.11.2-1.2-1.2-1.2-1.1-1.2-1.11.4
Short access day 10 total inactive lever presses0.00.30.40.5-0.6-0.6-0.50.7-0.6-0.5-0.5-0.6-0.5-0.40.6
Short access day 1 total infusions0.10.20.40.6-0.3-0.3-0.40.2-0.3-0.4-0.5-0.3-0.4-0.60.3
Short access day 10 total infusions0.50.80.90.8-0.9-0.7-0.80.8-1.0-0.9-0.9-1.0-0.9-0.90.8
Short access total infusions0.91.31.61.3-1.1-1.1-1.11.0-1.2-1.2-1.2-1.0-1.2-1.21.0
Short access day 1 locomotion0.00.10.2-0.20.20.2-0.0-0.30.20.20.00.40.20.0-0.4
Short access day 10 total locomotion0.00.20.50.3-0.5-0.5-0.70.5-0.5-0.3-0.4-0.2-0.2-0.20.4
Short access total locomotion0.20.30.60.5-0.6-0.6-0.80.6-0.6-0.5-0.6-0.2-0.4-0.50.3
One hour access (0.3 mA shock)0.00.00.10.2-0.1-0.10.10.0-0.2-0.1-0.10.2-0.10.0-0.0
Compulsive drug intake0.00.10.10.3-0.2-0.3-0.30.1-0.3-0.3-0.3-0.2-0.3-0.20.3
One hour access (shock baseline)0.10.20.3-0.30.40.50.5-0.40.40.40.40.60.40.3-0.5
Social response proportion0.20.30.80.9-0.5-0.6-0.30.6-0.6-0.5-0.4-0.6-0.5-0.10.6
Social responses7.810.212.53.5-3.2-3.4-3.13.4-3.4-3.1-3.1-3.1-3.1-2.53.3
Social time0.10.10.40.5-0.4-0.30.10.3-0.2-0.5-0.2-0.1-0.5-0.00.6
Soleus weight0.72.23.1-1.71.71.31.4-1.31.41.61.41.51.51.4-1.4
Bone: stiffness15.828.829.7-5.35.35.45.4-5.45.45.35.35.55.35.3-5.4
Tibialis anterior weight2.17.49.0-2.92.82.62.4-2.62.52.82.53.02.82.8-2.9
Time to tail flick, vehicle, before self-admin2.12.63.61.6-1.6-1.6-1.71.6-1.9-1.6-1.6-1.6-1.6-1.51.4
Time to tail flick, vehicle, after self-admin0.00.10.20.3-0.00.10.30.00.20.20.30.40.20.5-0.3
Time to tail flick, test, before self-admin0.50.61.30.6-0.7-0.7-0.70.6-0.5-0.7-0.7-1.0-0.7-1.10.8
Time to tail flick, test, after self-admin0.40.40.6-0.50.70.70.6-0.60.80.60.70.50.60.6-0.5
Delta time to tail flick, vehicle, before/after SA0.60.71.0-0.60.70.81.0-0.81.00.80.90.80.80.9-0.8
Delta time to tail flick, test, before/after SA0.30.40.6-0.40.70.70.5-0.60.60.60.60.80.60.8-0.7
Tibia length7.520.822.3-4.54.34.64.7-4.44.64.54.74.74.54.7-4.4
Ambulatory time before self-admin0.72.22.71.5-1.6-1.6-1.41.7-1.5-1.4-1.4-1.4-1.4-1.51.4
Ambulatory time after self-admin0.71.11.41.0-1.1-1.2-0.91.1-1.0-1.0-1.0-1.2-1.0-1.11.0
Bone: tissue strength0.50.50.7-0.60.60.60.7-0.70.70.70.80.70.70.7-0.8
Total heroin consumption1.11.31.6-1.21.01.11.1-1.01.11.21.21.31.21.3-1.3
Bone: trabecular number4.38.19.1-3.02.82.92.9-3.03.02.72.82.92.62.7-2.9
Bone: trabecular spacing1.52.22.71.6-1.4-1.4-1.61.6-1.6-1.3-1.4-1.6-1.3-1.41.6
Bone: trabecular thickness0.00.10.10.3-0.3-0.3-0.10.3-0.1-0.4-0.2-0.1-0.4-0.10.1
Bone: trabecular tissue density0.00.10.20.4-0.4-0.3-0.20.4-0.2-0.1-0.1-0.1-0.1-0.20.1
Water consumed over 24 hours0.10.10.3-0.50.50.40.2-0.30.30.40.30.30.30.2-0.4
Number of responses in last shaping day0.10.10.4-0.00.20.2-0.1-0.20.20.30.20.60.30.5-0.4