Hub : Genes

Pex6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Pex6 0.33 0.1 0.0e+00 0.45 0.47 0.47 0.47 1.4e-76 1.3e-80 1.4e-80 1.5e-79
2 Liver mRNA stability Pex6 0.13 0.08 4.5e-14 0.11 0.12 0.11 0.11 2.9e-12 6.6e-13 2.9e-12 3.0e-12
3 LHb gene expression Pex6 0.26 0.15 1.7e-04 0.16 0.11 0.16 0.14 1.6e-04 1.7e-03 1.5e-04 3.1e-04
4 NAcc mRNA stability Pex6 0.02 0.02 1.4e-03 0.02 0.02 0.01 0.02 2.9e-04 6.3e-04 3.8e-02 3.8e-04
5 IC gene expression Pex6 0.68 0.12 0.0e+00 0.44 0.44 0.43 0.44 3.1e-20 1.8e-20 6.9e-20 5.4e-20
6 Brain gene expression Pex6 0.39 0.13 0.0e+00 0.45 0.43 0.44 0.44 5.7e-46 3.1e-43 4.3e-45 4.6e-45
7 Adipose mRNA stability Pex6 0.07 0.04 6.4e-09 0.07 0.06 0.06 0.06 4.5e-08 1.4e-07 4.6e-07 2.1e-07
8 Eye gene expression Pex6 0.41 0.16 1.1e-04 0.26 0.18 0.13 0.22 5.9e-05 9.0e-04 4.6e-03 3.2e-04
9 PL gene expression Pex6 0.46 0.13 0.0e+00 0.58 0.61 0.61 0.61 1.3e-78 8.4e-85 7.2e-85 6.5e-85
10 Adipose gene expression Pex6 0.34 0.12 0.0e+00 0.37 0.36 0.36 0.36 5.0e-43 3.6e-42 4.9e-42 3.8e-42
11 IL gene expression Pex6 0.53 0.16 6.9e-11 0.35 0.33 0.32 0.33 2.4e-09 1.0e-08 1.4e-08 8.3e-09
12 pVTA mRNA stability Pex6 0.03 0.03 5.5e-03 0.02 0.02 0.01 0.01 7.7e-03 1.2e-02 4.0e-02 2.5e-02
13 OFC gene expression Pex6 0.53 0.15 6.9e-12 0.41 0.41 0.41 0.42 6.9e-11 6.7e-11 6.2e-11 3.8e-11
14 Liver gene expression Pex6 0.43 0.12 0.0e+00 0.43 0.44 0.44 0.44 8.0e-52 3.7e-53 2.4e-54 6.4e-54
15 BLA gene expression Pex6 0.75 0.01 0.0e+00 0.55 0.56 0.56 0.57 4.3e-34 2.1e-35 3.9e-35 2.6e-36
16 pVTA gene expression Pex6 0.5 0.13 0.0e+00 0.45 0.47 0.47 0.46 7.9e-40 1.6e-42 2.1e-42 2.3e-41
17 RMTg gene expression Pex6 0.24 0.12 4.2e-05 0.09 0.16 0.16 0.15 2.6e-03 5.6e-05 6.2e-05 1.1e-04
18 Liver intron excision ratio chr9_21765281_21767007 0.06 0.04 8.9e-08 0.05 0.05 0.05 0.05 1.3e-06 1.4e-06 6.5e-06 1.3e-06
19 Liver intron excision ratio chr9_21764447_21765118 0.06 0.04 2.5e-08 0.06 0.06 0.06 0.06 5.1e-07 6.8e-07 3.0e-07 2.6e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bone: apparent density0.40.70.90.60.60.90.90.70.90.91.01.01.00.90.90.90.70.90.80.20.7-0.8
Area under the delay curve8.59.911.93.23.23.23.53.23.13.13.13.03.13.03.03.03.33.03.23.3-3.23.1
BMI with tail3.411.714.9-3.4-3.5-3.7-3.7-3.5-3.6-3.5-3.5-3.7-3.6-3.9-3.9-3.9-3.3-3.6-3.4-2.81.8-1.7
BMI without tail5.015.418.3-4.0-4.1-4.1-4.1-4.0-4.0-4.0-4.0-4.1-3.9-4.3-4.3-4.3-3.9-4.1-3.9-3.62.8-2.7
Body weight4.620.322.8-4.7-4.8-4.6-4.7-4.7-4.6-4.5-4.5-4.5-4.5-4.7-4.7-4.7-4.5-4.5-4.4-4.33.8-3.7
Weight adjusted by age0.50.71.2-0.7-0.7-0.8-0.7-0.8-0.8-0.9-0.9-1.1-0.8-1.1-1.1-1.1-0.7-1.1-0.8-0.80.5-0.5
Bone surface1.22.23.11.31.31.61.61.41.61.71.71.71.71.61.61.61.31.61.60.90.2-0.2
Bone volume0.61.01.40.80.91.11.10.91.11.21.21.21.21.11.11.10.91.11.00.50.3-0.4
Breakpoint value in progressive ratio session0.10.10.80.20.30.20.00.2-0.0-0.00.20.20.00.10.10.10.30.30.10.5-0.90.9
Number of licking bursts3.35.47.3-2.3-2.3-2.2-2.2-2.4-2.3-2.2-2.2-2.2-2.2-2.2-2.2-2.2-2.4-2.3-2.5-2.72.4-2.4
Context. condit. distance diff. score0.30.30.9-0.7-0.6-0.4-0.4-0.6-0.5-0.4-0.5-0.5-0.4-0.5-0.5-0.5-0.6-0.6-0.4-0.50.9-1.0
Locomotion velocity, session 10.30.40.6-0.5-0.5-0.7-0.7-0.5-0.6-0.7-0.7-0.7-0.8-0.7-0.7-0.7-0.5-0.6-0.5-0.0-0.50.5
Locomotion distance, session 12.12.63.0-1.7-1.7-1.7-1.7-1.7-1.6-1.7-1.7-1.7-1.7-1.7-1.7-1.7-1.6-1.7-1.5-1.41.2-1.1
Locomotion velocity, session 24.95.77.5-2.5-2.5-2.4-2.4-2.4-2.5-2.6-2.6-2.6-2.6-2.7-2.7-2.7-2.1-2.5-2.2-1.71.3-1.2
Locomotion distance, session 21.11.51.9-1.3-1.3-1.4-1.3-1.3-1.3-1.3-1.4-1.3-1.3-1.3-1.3-1.3-1.2-1.3-1.2-0.90.5-0.5
Locomotion velocity, session 30.40.40.6-0.5-0.6-0.6-0.7-0.5-0.7-0.8-0.7-0.8-0.7-0.8-0.8-0.8-0.5-0.7-0.5-0.1-0.40.4
Locomotion distance, session 31.11.22.01.21.11.01.01.21.01.01.11.01.00.80.80.81.20.91.21.4-1.41.4
Stereotopy head waving bouts, day 31.31.52.1-1.3-1.3-1.4-1.4-1.3-1.4-1.2-1.3-1.2-1.2-1.1-1.1-1.1-1.4-1.2-1.4-1.30.9-0.9
Stereotopy head waving duration, day 31.72.02.8-1.5-1.5-1.7-1.6-1.5-1.6-1.5-1.6-1.5-1.5-1.3-1.3-1.3-1.5-1.4-1.7-1.30.6-0.6
Locomotion velocity, session 70.10.20.6-0.2-0.2-0.4-0.4-0.2-0.4-0.4-0.3-0.4-0.3-0.4-0.4-0.4-0.2-0.4-0.10.3-0.70.7
Locomotion distance, session 70.10.10.70.0-0.0-0.2-0.2-0.0-0.2-0.1-0.1-0.2-0.1-0.3-0.3-0.3-0.1-0.20.00.4-0.80.8
Stereotopy head waving bouts, day 70.20.20.6-0.5-0.5-0.4-0.3-0.5-0.4-0.3-0.3-0.3-0.3-0.0-0.0-0.0-0.4-0.2-0.5-0.60.7-0.8
Stereotopy head waving duration, day 70.10.10.4-0.1-0.00.10.1-0.00.10.10.10.20.10.40.40.40.00.2-0.0-0.30.6-0.6
Locomotion velocity, session 80.40.50.8-0.8-0.8-0.6-0.6-0.7-0.7-0.8-0.8-0.8-0.9-0.8-0.8-0.8-0.6-0.8-0.6-0.50.6-0.6
Locomotion distance, session 81.01.41.9-1.4-1.3-1.2-1.2-1.2-1.2-1.1-1.2-1.2-1.1-1.2-1.2-1.2-1.2-1.2-1.1-1.01.1-1.0
Degree of sensitization distance1.51.52.0-1.3-1.3-1.4-1.4-1.3-1.4-1.3-1.4-1.3-1.3-1.1-1.1-1.1-1.4-1.2-1.3-1.00.6-0.5
Degree of sensitization stereotypy0.40.50.90.50.50.70.70.60.60.70.70.70.80.90.90.90.70.80.60.40.1-0.1
Conditioned locomotion2.83.25.91.91.81.61.51.81.61.71.71.61.71.51.51.51.71.61.82.1-2.42.4
Cocaine response after cond. corrected0.20.20.30.50.50.40.40.50.50.50.50.50.50.50.50.50.40.50.40.3-0.40.4
Cocaine response after cond. not corrected0.40.50.60.80.80.60.60.70.80.60.60.60.60.80.80.80.70.70.60.7-0.70.7
Cocaine response before conditioning0.00.00.30.10.10.1-0.10.0-0.0-0.2-0.2-0.1-0.30.00.00.00.20.10.00.3-0.50.5
Saline control response0.00.00.1-0.0-0.00.10.10.00.10.1-0.0-0.0-0.00.10.10.10.20.10.20.3-0.10.1
Bone: connectivity density0.71.11.60.90.91.11.10.91.21.21.31.31.21.21.21.20.81.10.90.20.7-0.8
Bone: cortical apparent density0.50.71.00.80.80.90.80.90.80.80.80.80.80.90.90.90.90.90.91.0-0.80.7
Bone: cortical area0.30.51.0-0.9-1.0-0.8-0.7-0.8-0.9-0.8-0.8-0.8-0.7-0.7-0.7-0.7-0.6-0.6-0.4-0.20.3-0.3
Bone: cortical porosity0.10.10.2-0.2-0.3-0.4-0.4-0.3-0.3-0.2-0.3-0.3-0.3-0.3-0.3-0.3-0.4-0.3-0.3-0.40.4-0.4
Bone: cortical porosity0.10.10.2-0.2-0.2-0.4-0.4-0.2-0.3-0.2-0.3-0.3-0.2-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.00.1
Bone: cortical thickness0.40.71.0-1.0-1.0-0.8-0.8-0.8-0.9-1.0-0.9-1.0-0.9-1.0-1.0-1.0-0.6-0.9-0.5-0.20.3-0.3
Bone: cortical thickness0.00.00.20.10.00.20.10.10.10.20.20.20.20.10.10.10.10.10.2-0.00.5-0.5
Bone: cortical tissue density0.60.81.00.80.90.90.80.90.90.80.80.90.80.90.90.90.90.91.01.0-0.80.8
Condit. Reinf. active minus inactive responses1.51.72.1-1.4-1.3-1.4-1.3-1.4-1.4-1.4-1.4-1.4-1.4-1.3-1.3-1.3-1.3-1.3-1.4-1.30.9-0.9
Condit. Reinf. active-inactive response ratio0.30.40.6-0.6-0.6-0.6-0.6-0.6-0.5-0.5-0.6-0.6-0.5-0.5-0.5-0.5-0.7-0.6-0.7-0.80.7-0.7
Condit. Reinf. active responses2.73.43.9-2.0-2.0-1.9-1.9-1.9-1.9-2.0-1.9-1.9-1.9-1.7-1.7-1.7-1.9-1.8-1.9-1.71.5-1.5
Condit. Reinf. inactive responses2.12.63.4-1.8-1.8-1.7-1.9-1.7-1.7-1.7-1.6-1.6-1.6-1.4-1.4-1.4-1.7-1.5-1.6-1.61.4-1.4
Incentive salience index mean1.92.32.8-1.7-1.7-1.6-1.6-1.6-1.7-1.7-1.7-1.7-1.6-1.5-1.5-1.5-1.5-1.5-1.5-1.20.9-0.9
Condit. Reinf. lever presses3.34.65.8-2.4-2.4-2.3-2.3-2.3-2.3-2.3-2.3-2.3-2.2-2.1-2.1-2.1-2.0-2.0-2.1-1.81.4-1.4
Condit. Reinf. active minus inactive responses0.20.20.8-0.4-0.3-0.2-0.1-0.4-0.2-0.4-0.4-0.4-0.4-0.3-0.3-0.3-0.4-0.4-0.4-0.70.9-0.9
Condit. Reinf. active-inactive response ratio1.31.52.8-1.2-1.1-0.9-0.9-1.2-1.0-1.3-1.3-1.3-1.2-1.1-1.1-1.1-1.3-1.3-1.2-1.51.7-1.7
Condit. Reinf. active responses0.00.10.2-0.2-0.1-0.10.0-0.2-0.1-0.2-0.3-0.2-0.2-0.1-0.1-0.1-0.2-0.2-0.2-0.30.4-0.4
Condit. Reinf. inactive responses0.10.10.40.30.20.20.30.30.20.30.30.30.30.30.30.30.40.40.30.5-0.60.6
Condit. Reinf. lever presses0.71.01.6-1.1-1.1-1.0-0.8-1.1-0.9-0.9-0.9-1.0-0.9-0.8-0.8-0.8-1.1-1.0-1.0-1.21.3-1.3
Condit. Reinf. lever reinforcers received0.00.00.2-0.2-0.10.00.1-0.1-0.1-0.2-0.2-0.1-0.1-0.1-0.1-0.1-0.1-0.2-0.1-0.30.4-0.4
Conditioned reinforcement - actives0.50.92.70.70.80.60.70.80.70.70.80.80.70.80.80.81.01.00.91.4-1.61.6
Conditioned reinforcement - inactives0.10.20.5-0.6-0.6-0.7-0.7-0.5-0.5-0.5-0.4-0.4-0.5-0.3-0.3-0.3-0.4-0.2-0.5-0.3-0.00.0
Conditioned locomotion0.20.20.4-0.5-0.5-0.6-0.5-0.5-0.4-0.5-0.4-0.4-0.5-0.5-0.5-0.5-0.4-0.4-0.5-0.50.3-0.3
Patch foraging indifference point 0 sec0.71.31.7-1.2-1.2-1.3-1.1-1.2-1.3-1.2-1.3-1.2-1.1-1.1-1.1-1.1-1.2-1.1-1.3-1.20.7-0.7
Patch foraging indifference point AUC0.40.50.8-0.6-0.6-0.8-0.7-0.6-0.8-0.9-0.9-0.8-0.9-0.8-0.8-0.8-0.5-0.6-0.60.0-0.70.8
Delay disc. indifference point, 0s delay2.02.23.61.81.91.51.71.61.41.41.31.21.31.11.11.11.61.21.21.4-1.91.9
Delay disc. indifference point, 16s delay11.712.814.43.63.63.73.83.73.63.53.63.53.63.63.63.63.63.53.73.7-3.33.2
Delay disc. indifference point, 2s delay3.43.85.02.22.22.12.22.01.91.81.81.71.81.61.61.62.11.81.92.1-2.22.2
Delay disc. indifference point, 24s delay0.80.91.71.01.01.31.31.01.10.91.00.91.00.90.90.91.00.81.20.9-0.40.4
Delay disc. indifference point, 4s delay4.64.89.42.12.11.92.12.12.02.12.01.92.02.02.02.02.32.02.12.6-3.03.1
Delay disc. indifference point, 8s delay5.15.97.12.52.52.42.72.52.42.42.42.32.42.32.32.32.52.32.52.6-2.52.5
Indifference point function ln k0.40.61.11.01.00.80.70.90.90.80.90.70.90.60.60.60.80.70.70.7-0.80.8
Indifference point function log k0.40.61.11.01.00.80.70.90.90.80.90.70.90.60.60.60.80.70.70.7-0.80.8
Patch foraging total patch changes 0 sec0.91.62.2-1.3-1.3-1.4-1.3-1.3-1.5-1.3-1.4-1.3-1.2-1.2-1.2-1.2-1.3-1.2-1.4-1.30.8-0.7
Patch foraging total patch changes 12 sec0.60.81.4-1.1-1.1-1.1-0.9-1.0-1.2-1.0-1.1-0.9-0.9-1.0-1.0-1.0-0.8-0.9-0.8-0.4-0.00.1
Patch foraging total patch changes 18 sec0.81.22.0-1.1-1.1-1.3-1.2-1.1-1.4-1.2-1.3-1.2-1.1-1.2-1.2-1.2-1.0-1.1-1.1-0.6-0.00.1
Patch foraging total patch changes 24 sec0.40.61.1-0.9-0.9-1.0-0.9-0.9-1.1-0.8-0.8-0.8-0.9-0.7-0.7-0.7-0.8-0.7-0.9-0.50.1-0.1
Patch foraging total patch changes 6 sec2.13.24.0-2.0-2.0-1.9-1.8-1.9-1.9-1.9-1.9-1.8-1.9-1.9-1.9-1.9-1.7-1.7-1.7-1.51.2-1.1
Patch foraging time to switch 0 sec2.75.47.12.22.32.72.62.42.62.62.62.62.62.62.62.62.12.42.61.7-0.40.3
Patch foraging water rate 0 sec1.22.53.7-1.5-1.5-1.9-1.9-1.6-1.9-1.7-1.8-1.7-1.7-1.8-1.8-1.8-1.3-1.5-1.6-0.5-0.91.0
Patch foraging water rate 12 sec3.16.58.7-2.6-2.7-2.9-2.9-2.7-2.8-2.7-2.6-2.8-2.8-2.7-2.7-2.7-2.5-2.6-2.7-2.11.2-1.1
Patch foraging water rate 18 sec0.91.31.9-1.2-1.2-1.4-1.3-1.2-1.4-1.2-1.2-1.2-1.3-1.2-1.2-1.2-1.1-1.1-1.3-0.90.3-0.3
Patch foraging water rate 24 sec1.42.02.7-1.3-1.4-1.6-1.6-1.5-1.6-1.6-1.5-1.5-1.6-1.5-1.5-1.5-1.3-1.4-1.6-1.10.2-0.1
Patch foraging water rate 6 sec0.20.20.9-0.2-0.2-0.5-0.6-0.3-0.5-0.4-0.4-0.5-0.4-0.5-0.5-0.5-0.1-0.4-0.30.2-0.90.9
Seeking ratio, delayed vs. immediate footshock1.72.13.11.41.51.51.51.41.81.61.51.51.61.61.61.61.51.51.41.1-0.60.6
Distance traveled before self-admin0.00.00.1-0.1-0.1-0.2-0.3-0.1-0.2-0.00.1-0.2-0.1-0.2-0.2-0.2-0.1-0.2-0.10.1-0.30.3
Distance traveled after self-admin1.72.22.8-1.4-1.4-1.6-1.6-1.5-1.6-1.5-1.5-1.6-1.6-1.7-1.7-1.7-1.4-1.6-1.6-1.30.5-0.4
Extensor digitorum longus weight0.10.30.6-0.5-0.6-0.6-0.8-0.5-0.6-0.5-0.5-0.5-0.6-0.6-0.6-0.6-0.5-0.5-0.4-0.30.2-0.2
Bone: elastic displacement0.40.50.90.70.70.90.90.70.80.60.60.60.60.50.50.50.80.60.80.7-0.30.3
Bone: elastic work0.10.10.9-0.4-0.30.10.1-0.2-0.1-0.2-0.1-0.2-0.1-0.2-0.2-0.2-0.1-0.20.1-0.20.9-1.0
Bone: endosteal estimation0.40.91.30.90.90.80.90.90.91.01.01.11.01.21.21.20.91.10.80.6-0.50.4
Bone: endosteal perimeter0.00.00.1-0.3-0.3-0.3-0.1-0.2-0.2-0.1-0.1-0.0-0.10.10.10.1-0.20.0-0.2-0.20.3-0.3
Epididymis fat weight3.110.712.4-3.5-3.5-3.3-3.3-3.4-3.3-3.1-3.1-3.1-3.1-3.2-3.2-3.2-3.4-3.2-3.2-3.43.3-3.3
Delta time in closed arm before/after self-admin0.20.21.7-0.2-0.3-0.0-0.0-0.2-0.00.20.30.10.0-0.0-0.0-0.0-0.4-0.2-0.1-0.71.3-1.3
Delta time in open arm before/after self-admin0.30.31.40.60.60.30.40.50.30.20.20.40.40.50.50.50.60.60.30.6-1.21.2
Diff in mean of infusions in LGA sessions0.50.60.9-0.8-0.7-1.0-1.0-0.8-0.9-0.8-0.9-0.7-0.9-0.8-0.8-0.8-0.6-0.6-0.9-0.5-0.20.2
Delay discount exponential model param8.59.511.5-3.1-3.2-3.2-3.4-3.2-3.1-3.0-3.0-2.9-3.0-2.9-2.9-2.9-3.2-3.0-3.2-3.33.0-3.0
Extinction: sum of active levers before priming0.10.10.80.10.2-0.1-0.00.0-0.1-0.00.0-0.1-0.2-0.2-0.2-0.20.1-0.1-0.10.3-0.90.9
Active lever presses in extinction session 60.20.20.7-0.2-0.1-0.4-0.3-0.2-0.4-0.4-0.3-0.4-0.5-0.3-0.3-0.3-0.1-0.2-0.40.1-0.80.8
Bone: final force0.40.61.3-1.1-1.1-0.8-0.7-0.9-0.9-0.7-0.7-0.7-0.7-0.6-0.6-0.6-0.7-0.6-0.6-0.71.1-1.1
Bone: final moment0.30.40.9-0.9-0.9-0.7-0.6-0.7-0.8-0.6-0.6-0.6-0.6-0.5-0.5-0.5-0.6-0.5-0.4-0.40.7-0.7
Food consumed during 24 hour testing period0.30.40.6-0.5-0.6-0.7-0.7-0.6-0.8-0.8-0.8-0.8-0.8-0.7-0.7-0.7-0.6-0.7-0.7-0.3-0.30.4
Glucose6.910.812.2-3.4-3.4-3.4-3.5-3.4-3.3-3.3-3.4-3.5-3.2-3.5-3.5-3.5-3.3-3.5-3.3-3.12.4-2.4
Heart weight0.10.10.3-0.5-0.5-0.4-0.3-0.4-0.4-0.4-0.4-0.3-0.3-0.4-0.4-0.4-0.3-0.2-0.3-0.10.1-0.0
Delay discount hyperbolic model param7.68.510.4-3.0-3.0-3.0-3.2-3.0-2.9-2.9-2.9-2.8-2.9-2.8-2.8-2.8-3.0-2.8-3.0-3.12.9-2.9
Intermittent access intake day 1-15 change0.00.00.0-0.2-0.2-0.00.0-0.1-0.1-0.1-0.0-0.1-0.1-0.0-0.0-0.0-0.1-0.10.00.1-0.10.1
Intermittent access intake escalation0.00.00.0-0.1-0.10.00.1-0.0-0.00.00.0-0.0-0.00.00.00.0-0.0-0.00.10.1-0.00.0
Intermittent access intake escalation 20.10.10.30.20.20.30.40.30.30.30.40.30.30.30.30.30.40.40.40.6-0.60.6
Intermitt. access day 1 inactive lever presses0.41.73.0-1.2-1.2-1.1-1.2-1.3-1.2-1.2-1.0-1.2-1.3-1.1-1.1-1.1-1.4-1.3-1.3-1.61.7-1.7
Intermitt. access day 15 inactive lever presses0.40.71.2-0.8-0.9-1.0-1.1-0.8-0.7-0.8-0.7-0.8-0.8-0.9-0.9-0.9-0.9-0.9-0.8-0.90.8-0.7
Intermitt. access escalation Index0.00.00.00.20.10.0-0.00.10.10.0-0.0-0.00.20.10.10.10.1-0.00.10.0-0.10.1
Intermittent access day 1 total infusions0.50.71.2-0.9-0.9-1.1-1.1-0.9-0.8-0.8-0.8-0.7-0.8-0.8-0.8-0.8-0.9-0.8-1.0-0.90.6-0.6
Intermittent access day 15 total infusions0.30.40.8-0.7-0.7-0.9-0.8-0.7-0.6-0.6-0.5-0.6-0.6-0.5-0.5-0.5-0.7-0.5-0.8-0.70.5-0.5
Intermittent access terminal intake (last 3 days)0.00.00.1-0.1-0.1-0.3-0.2-0.10.10.10.10.10.10.20.20.2-0.00.2-0.1-0.0-0.10.1
Intermittent access total infusions0.10.10.4-0.4-0.4-0.6-0.6-0.4-0.3-0.3-0.3-0.2-0.3-0.2-0.2-0.2-0.4-0.2-0.4-0.30.1-0.1
Intermittent access day 1 locomotion0.81.11.6-1.0-1.0-1.3-1.2-1.1-1.0-0.9-1.0-0.9-1.0-1.0-1.0-1.0-1.1-1.0-1.1-1.21.0-1.0
Intermittent access day 15 total locomotion0.71.21.6-1.2-1.2-1.2-1.1-1.2-1.0-1.0-1.1-1.1-1.0-1.3-1.3-1.3-1.1-1.1-1.1-1.10.8-0.8
Intermittent access total locomotion0.70.81.2-0.9-0.9-1.1-1.0-1.0-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-1.0-0.9-1.0-1.11.0-1.0
Intermittent access standard deviation1.12.23.01.41.41.61.61.51.71.71.71.71.71.61.61.61.41.61.61.2-0.40.4
Left kidney weight1.46.47.7-2.7-2.8-2.7-2.7-2.7-2.8-2.6-2.6-2.6-2.6-2.6-2.6-2.6-2.5-2.5-2.5-2.11.6-1.5
Right kidney weight1.25.67.5-2.5-2.5-2.6-2.5-2.5-2.7-2.5-2.6-2.5-2.5-2.7-2.7-2.7-2.3-2.4-2.4-1.70.7-0.7
Cocaine induced anxiety0.20.31.0-0.4-0.4-0.3-0.2-0.4-0.3-0.3-0.3-0.4-0.3-0.4-0.4-0.4-0.5-0.5-0.4-0.81.0-1.0
Post-drug Anxiety0.20.20.8-0.4-0.4-0.1-0.1-0.3-0.3-0.3-0.3-0.4-0.3-0.4-0.4-0.4-0.4-0.5-0.3-0.60.9-0.9
Baseline Anxiety0.50.61.10.80.80.80.60.80.70.70.70.70.70.70.70.70.80.80.91.0-0.90.9
Tail length1.66.37.9-2.7-2.7-2.4-2.3-2.6-2.4-2.4-2.4-2.4-2.3-2.4-2.4-2.4-2.7-2.5-2.3-2.62.8-2.8
Length with tail1.46.011.3-2.7-2.6-2.2-2.2-2.5-2.2-2.1-2.2-2.1-2.2-2.2-2.2-2.2-2.6-2.3-2.3-2.83.4-3.4
Length without tail0.82.54.7-1.8-1.7-1.5-1.5-1.6-1.4-1.4-1.4-1.3-1.5-1.4-1.4-1.4-1.5-1.4-1.4-1.62.2-2.2
Times rat made contact with spout5.66.57.3-2.6-2.5-2.5-2.4-2.6-2.5-2.6-2.6-2.6-2.6-2.6-2.6-2.6-2.6-2.7-2.7-2.72.2-2.2
Lifetime Intake0.10.10.10.20.2-0.00.00.20.30.30.30.40.30.40.40.40.20.40.10.2-0.30.3
Liver weight, left0.10.20.4-0.4-0.4-0.4-0.6-0.3-0.4-0.5-0.5-0.6-0.4-0.6-0.6-0.6-0.1-0.5-0.10.3-0.50.6
Liver weight, right2.44.25.3-2.3-2.3-2.0-2.1-2.1-2.1-2.1-2.1-2.2-2.1-2.2-2.2-2.2-1.9-2.1-1.8-1.71.7-1.7
Locomotor activity2.94.65.3-2.2-2.2-1.9-1.9-2.1-2.0-2.1-2.2-2.2-2.3-2.2-2.2-2.2-2.1-2.3-1.9-2.02.3-2.3
Locomotor testing distance2.64.76.3-2.3-2.2-2.0-2.0-2.2-1.9-2.2-2.2-2.2-2.3-2.1-2.1-2.1-2.2-2.2-1.9-2.22.5-2.5
Locomotor testing rearing2.14.35.7-2.1-2.1-2.2-2.1-2.1-2.2-2.4-2.4-2.3-2.3-2.2-2.2-2.2-2.0-2.2-2.1-1.61.0-0.9
Locomotion in novel chamber1.01.21.41.01.01.01.11.11.01.21.21.11.21.11.11.11.21.11.11.1-1.01.0
Locomotion in novel chamber post-restriction1.01.64.11.21.10.90.81.21.01.11.11.11.11.11.11.11.41.21.11.6-2.02.0
Fecal boli incidents, locomotor time 10.50.82.80.80.80.60.40.80.60.80.70.80.70.50.50.50.90.80.81.3-1.61.7
Change in fecal boli incidents, locomotor task0.30.30.90.40.50.30.40.40.40.30.30.30.30.60.60.60.50.50.30.5-0.90.9
Time >=10cm from walls, locomotor time 10.20.20.4-0.4-0.4-0.7-0.5-0.4-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.3-0.6-0.2-0.40.4
Bouts of movement, locomotor time 10.10.10.30.20.2-0.00.10.10.10.30.40.40.20.40.40.4-0.10.3-0.2-0.40.6-0.6
Total resting periods, locomotor time 10.20.20.8-0.3-0.3-0.5-0.4-0.4-0.4-0.2-0.2-0.2-0.4-0.2-0.2-0.2-0.6-0.3-0.7-0.90.9-0.9
Rest time, locomotor task time 10.70.91.31.01.10.80.90.90.91.01.11.11.01.01.01.00.91.10.70.8-0.90.9
Distance moved, locomotor task time 10.10.10.4-0.4-0.4-0.3-0.2-0.3-0.2-0.3-0.4-0.4-0.3-0.2-0.2-0.2-0.3-0.4-0.2-0.40.6-0.7
Vertical activity count, locomotor time 10.20.50.90.70.70.90.90.80.90.70.60.60.70.70.70.70.90.60.90.8-0.30.3
Time >=10cm from walls, locomotor time 20.20.30.7-0.5-0.6-0.9-0.7-0.6-0.7-0.5-0.4-0.4-0.6-0.6-0.6-0.6-0.6-0.4-0.7-0.3-0.30.4
Bouts of movement, locomotor time 20.20.30.4-0.7-0.6-0.7-0.5-0.6-0.5-0.5-0.5-0.5-0.5-0.3-0.3-0.3-0.6-0.5-0.6-0.70.6-0.6
Total resting periods, locomotor time 20.00.10.2-0.3-0.3-0.3-0.2-0.3-0.2-0.2-0.2-0.1-0.10.10.10.1-0.3-0.1-0.4-0.40.4-0.4
Rest time, locomotor task time 20.40.50.90.80.90.70.80.70.71.00.80.90.80.70.70.70.60.70.50.4-0.30.3
Distance moved, locomotor task time 21.01.21.5-1.0-1.2-1.2-1.2-1.1-1.1-1.2-1.1-1.1-1.2-1.1-1.1-1.1-1.1-1.1-1.1-1.10.9-0.8
Vertical activity count, locomotor time 20.10.20.30.40.30.40.50.40.40.20.30.30.30.20.20.20.60.30.40.6-0.50.6
Light reinforcement 11.23.03.8-1.8-1.8-1.9-1.9-1.8-1.8-1.9-1.9-1.8-1.8-1.9-1.9-1.9-1.6-1.7-1.8-1.40.8-0.8
Light reinforcement 22.53.84.6-2.0-2.1-2.0-1.9-2.0-1.9-1.8-1.8-1.8-1.8-2.0-2.0-2.0-1.9-1.9-1.9-2.12.2-2.1
Bone: marrow area0.40.91.40.90.90.91.00.91.01.11.11.11.11.21.21.20.91.10.90.7-0.40.4
Bone: maximum diameter0.10.20.4-0.5-0.6-0.6-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.4-0.3-0.0-0.10.2
Bone: maximum force0.10.11.1-0.4-0.5-0.2-0.0-0.3-0.2-0.0-0.1-0.1-0.00.00.00.0-0.1-0.0-0.0-0.41.0-1.0
Bone: maximum moment0.00.10.4-0.3-0.3-0.10.0-0.2-0.10.00.0-0.00.00.10.10.10.00.00.1-0.10.6-0.6
Mean time between licks in bursts1.02.43.21.71.61.61.61.61.71.81.81.81.71.71.71.71.51.71.41.0-0.60.5
Mean num. licks in bursts0.60.91.61.00.90.80.91.00.80.80.80.80.80.80.80.80.90.90.91.1-1.21.2
Cd content in liver1.71.92.41.51.51.31.31.41.41.41.41.41.41.41.41.41.21.31.31.2-1.31.3
Co content in liver0.00.10.10.30.30.20.20.20.30.30.30.30.20.30.30.30.20.30.10.0-0.10.1
Cu content in liver0.30.41.60.60.60.50.50.60.50.40.40.40.40.40.40.40.60.50.50.8-1.21.3
Fe content in liver0.00.00.1-0.3-0.2-0.3-0.3-0.1-0.1-0.00.0-0.1-0.10.00.00.0-0.1-0.0-0.00.1-0.00.0
K content in liver0.30.32.1-0.2-0.10.20.2-0.10.20.20.10.10.10.10.10.1-0.2-0.00.0-0.61.4-1.5
Mg content in liver0.20.20.30.20.20.50.50.40.40.50.50.50.40.50.50.50.40.50.50.30.3-0.3
Mn content in liver0.40.51.0-0.5-0.5-0.6-0.6-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.8-0.9-1.00.6-0.6
Na content in liver0.60.61.0-1.0-1.0-0.7-0.7-0.8-0.8-0.8-0.8-0.9-0.8-0.8-0.8-0.8-0.6-0.8-0.6-0.50.7-0.7
Rb content in liver4.55.26.22.22.22.22.22.32.42.42.42.42.42.42.42.42.42.52.52.4-1.71.7
Se content in liver0.70.81.2-0.8-0.8-1.1-1.1-0.9-1.0-1.0-1.0-0.9-1.0-1.0-1.0-1.0-1.0-0.9-1.0-0.7-0.10.2
Sr content in liver0.80.70.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.8-0.9-0.9-0.60.3-0.2
Zn content in liver1.92.22.81.41.41.41.31.51.41.41.41.51.41.41.41.41.41.51.51.7-1.61.6
Bone: minimum diameter0.20.30.6-0.7-0.8-0.8-0.6-0.6-0.7-0.4-0.5-0.4-0.5-0.3-0.3-0.3-0.6-0.4-0.5-0.40.5-0.4
Time in familiar zone, hab. session 10.30.30.6-0.6-0.6-0.8-0.8-0.5-0.7-0.5-0.5-0.5-0.7-0.5-0.5-0.5-0.5-0.4-0.5-0.0-0.30.4
Time in novel zone, hab. session 10.50.51.11.01.00.90.90.80.90.70.70.70.90.70.70.70.80.60.50.3-0.50.4
Total zone transitions, hab. session 14.05.66.5-2.5-2.5-2.5-2.5-2.5-2.5-2.4-2.4-2.4-2.3-2.5-2.5-2.5-2.5-2.4-2.4-2.11.7-1.6
Total locomotion distance, hab. session 13.95.56.4-2.5-2.5-2.5-2.5-2.4-2.5-2.5-2.5-2.5-2.4-2.5-2.5-2.5-2.4-2.5-2.4-1.91.2-1.1
Locomotion velocity, hab. session 13.44.85.6-2.3-2.4-2.3-2.4-2.3-2.3-2.3-2.3-2.3-2.3-2.4-2.4-2.4-2.2-2.3-2.2-1.81.2-1.1
Time in familiar zone, hab. session 22.02.13.71.21.31.51.51.41.51.61.61.61.61.91.91.91.21.61.51.1-0.30.3
Time in novel zone, hab. session 20.40.40.8-0.3-0.4-0.6-0.6-0.5-0.6-0.7-0.7-0.7-0.6-0.9-0.9-0.9-0.4-0.7-0.7-0.4-0.30.4
Total zone transitions, hab. session 23.44.35.8-2.2-2.1-1.9-1.9-2.1-1.9-1.9-2.0-1.9-1.9-2.0-2.0-2.0-2.2-2.1-2.1-2.42.4-2.4
Total locomotion distance, hab. session 23.34.45.1-2.2-2.2-2.1-2.1-2.2-2.1-2.1-2.1-2.1-2.0-2.0-2.0-2.0-2.3-2.2-2.2-2.21.8-1.8
Locomotion velocity, hab. session 22.73.64.2-2.0-1.9-1.9-1.9-2.0-1.9-1.9-1.9-1.9-1.8-1.8-1.8-1.8-2.1-2.0-2.0-2.01.7-1.7
Novel to familiar place preference ratio0.10.10.1-0.3-0.3-0.2-0.2-0.3-0.4-0.3-0.3-0.3-0.4-0.3-0.3-0.3-0.3-0.3-0.2-0.20.3-0.3
Novelty place preference0.00.00.0-0.1-0.10.10.0-0.0-0.1-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.0-0.10.00.00.1-0.1
Time in novel zone, NPP test0.00.00.00.0-0.00.10.10.0-0.1-0.1-0.1-0.0-0.1-0.0-0.0-0.0-0.0-0.00.00.1-0.00.0
Total zone transitions, NPP test6.69.511.2-3.3-3.3-3.1-3.1-3.2-3.1-3.1-3.1-3.1-3.1-3.1-3.1-3.1-3.2-3.2-3.0-2.92.7-2.7
Total locomotion distance, NPP test6.18.49.6-3.1-3.1-2.8-2.8-3.0-2.9-2.9-2.9-3.0-2.9-2.9-2.9-2.9-3.1-3.0-2.8-2.82.6-2.5
Locomotion velocity, NPP test6.79.511.4-3.4-3.3-3.0-3.0-3.2-3.1-3.1-3.1-3.1-3.0-3.0-3.0-3.0-3.2-3.1-2.9-3.03.0-3.0
Intraocular pressure0.60.91.61.21.20.80.71.00.90.80.90.90.90.90.90.90.91.00.60.7-1.31.3
Delta distance traveled before/after self-admin2.83.04.2-1.6-1.6-1.7-1.6-1.8-1.8-1.8-2.0-1.8-1.8-1.8-1.8-1.8-1.7-1.8-1.9-1.91.3-1.3
Delta ambulatory time before/after self-admin3.03.75.2-1.8-1.8-1.9-1.8-2.0-2.0-2.0-2.3-2.0-2.0-2.0-2.0-2.0-1.9-2.0-2.2-2.01.3-1.3
Parametrial fat weight4.510.511.7-3.3-3.4-3.3-3.4-3.3-3.3-3.3-3.3-3.2-3.2-3.3-3.3-3.3-3.4-3.2-3.2-3.32.9-2.8
Pavlov. Cond. lever latency1.92.43.21.81.81.71.71.71.71.71.71.71.61.71.71.71.31.51.40.9-0.60.5
Pavlov. Cond. magazine entry latency0.30.30.8-0.5-0.5-0.7-0.7-0.4-0.6-0.7-0.6-0.6-0.6-0.5-0.5-0.5-0.2-0.4-0.40.2-0.80.9
Pavlov. Cond. change in total contacts1.41.52.3-1.2-1.2-1.5-1.5-1.3-1.4-1.4-1.3-1.4-1.1-1.4-1.4-1.4-1.0-1.2-1.3-0.7-0.10.2
Pavlov. Cond. index score1.72.23.0-1.6-1.6-1.7-1.7-1.5-1.7-1.7-1.6-1.7-1.6-1.6-1.6-1.6-1.1-1.4-1.4-0.70.1-0.1
Pavlov. Cond. latency score1.11.31.9-1.3-1.3-1.3-1.3-1.2-1.4-1.4-1.3-1.4-1.2-1.3-1.3-1.3-0.8-1.1-1.0-0.4-0.10.2
Pavlov. Cond. lever contacts2.22.63.5-1.8-1.8-1.8-1.8-1.7-1.8-1.9-1.7-1.8-1.7-1.8-1.8-1.8-1.3-1.6-1.6-1.10.6-0.6
Pavlov. Cond. magazine entry number1.51.92.71.51.51.61.61.41.61.61.51.61.51.41.41.41.11.31.40.70.0-0.1
Pavlov. Cond. intertrial magazine entries0.91.01.21.11.11.11.11.11.01.11.01.11.11.11.11.11.01.01.00.9-0.70.6
Pavlov. Cond. lever-magazine prob. diff.1.51.92.7-1.5-1.5-1.6-1.6-1.4-1.6-1.6-1.5-1.6-1.5-1.5-1.5-1.5-1.0-1.3-1.3-0.6-0.00.1
Pavlov. Cond. response bias2.73.34.5-2.0-2.0-2.1-2.1-1.9-2.1-2.1-2.0-2.1-2.0-1.9-1.9-1.9-1.6-1.8-1.8-1.20.5-0.4
Pavlov. Cond. lever latency3.04.15.22.32.22.01.92.12.01.91.92.01.91.81.81.82.22.02.02.2-2.22.2
Pavlov. Cond. magazine entry latency2.63.24.1-2.0-2.0-1.8-1.8-1.9-1.8-1.7-1.7-1.7-1.6-1.6-1.6-1.6-1.8-1.7-1.7-1.82.0-2.0
Pavlov. Cond. change in total contacts2.74.36.0-2.4-2.3-2.1-1.9-2.2-2.0-2.0-2.0-2.0-2.0-1.6-1.6-1.6-2.2-2.0-2.0-2.22.5-2.4
Pavlov. Cond. index score4.76.38.0-2.8-2.8-2.5-2.4-2.7-2.5-2.5-2.5-2.5-2.4-2.2-2.2-2.2-2.6-2.4-2.4-2.52.6-2.6
Pavlov. Cond. latency score5.16.78.5-2.9-2.9-2.6-2.6-2.8-2.6-2.6-2.5-2.6-2.5-2.3-2.3-2.3-2.7-2.5-2.5-2.62.6-2.6
Pavlov. Cond. lever contacts3.34.55.9-2.4-2.4-2.1-2.0-2.3-2.1-2.0-2.0-2.0-2.0-1.8-1.8-1.8-2.3-2.1-2.1-2.32.4-2.4
Pavlov. Cond. magazine entry number0.91.12.01.31.31.01.01.11.00.90.90.90.90.70.70.71.00.90.81.0-1.41.4
Pavlov. Cond. intertrial magazine entries0.00.00.20.20.20.10.10.10.10.00.0-0.0-0.0-0.3-0.3-0.30.1-0.10.00.1-0.50.5
Pavlov. Cond. lever-magazine prob. diff.4.96.58.4-2.9-2.8-2.6-2.5-2.7-2.6-2.5-2.5-2.5-2.5-2.2-2.2-2.2-2.7-2.5-2.5-2.62.7-2.7
Pavlov. Cond. response bias1.42.04.0-1.7-1.6-1.3-1.2-1.5-1.3-1.2-1.2-1.3-1.2-1.0-1.0-1.0-1.5-1.3-1.2-1.52.0-2.0
Time in closed arm before self-admin0.00.10.40.10.10.2-0.10.10.20.1-0.00.20.10.20.20.20.00.10.0-0.20.6-0.6
Time in closed arm after self-admin0.60.63.6-0.5-0.5-0.3-0.5-0.5-0.2-0.2-0.4-0.3-0.3-0.3-0.3-0.3-0.7-0.5-0.5-1.21.9-1.9
Time in open arm before self-admin1.61.82.5-1.5-1.5-1.6-1.4-1.4-1.5-1.4-1.2-1.5-1.4-1.5-1.5-1.5-1.3-1.4-1.4-0.90.3-0.3
Time in open arm after self-admin0.20.30.9-0.4-0.4-0.7-0.4-0.4-0.6-0.7-0.4-0.5-0.5-0.4-0.4-0.4-0.2-0.3-0.50.1-0.90.9
Bone: periosteal estimation0.00.00.1-0.3-0.3-0.3-0.1-0.2-0.3-0.1-0.1-0.1-0.10.00.00.0-0.10.0-0.10.0-0.00.0
Bone: periosteal perimeter0.71.32.1-1.4-1.4-1.2-1.1-1.2-1.2-1.1-1.1-1.0-1.1-1.0-1.0-1.0-1.2-1.0-0.9-0.91.2-1.2
Bone: post-yield work0.10.20.9-0.3-0.4-0.2-0.2-0.3-0.2-0.0-0.0-0.1-0.0-0.1-0.1-0.1-0.3-0.2-0.3-0.60.9-0.9
Progressive ratio test 1 active lever presses1.01.21.5-1.1-1.1-1.2-1.1-1.1-1.0-1.0-1.0-1.0-1.1-1.0-1.0-1.0-1.2-1.0-1.2-1.21.2-1.2
Progressive ratio test 1 breakpoint0.91.11.3-1.1-1.0-1.1-1.1-1.1-1.0-1.0-0.9-1.0-1.0-0.9-0.9-0.9-1.1-1.0-1.1-1.21.1-1.1
Progressive ratio test 1 inactive lever presses0.50.81.3-1.0-1.0-1.1-1.2-1.0-1.0-1.0-0.9-0.8-1.0-0.7-0.7-0.7-0.9-0.7-1.1-0.80.5-0.4
Progressive ratio test 2 active lever presses2.02.33.6-1.7-1.7-1.9-1.9-1.7-1.6-1.5-1.5-1.5-1.6-1.4-1.4-1.4-1.6-1.4-1.7-1.40.9-0.8
Progressive ratio test 2 breakpoint2.32.64.0-1.8-1.8-2.0-1.9-1.8-1.7-1.6-1.6-1.6-1.7-1.5-1.5-1.5-1.7-1.5-1.8-1.50.9-0.9
Progressive ratio test 2 inactive lever presses0.50.81.7-1.0-1.0-1.2-1.3-1.0-0.9-0.9-0.8-0.8-1.0-0.8-0.8-0.8-1.0-0.7-1.0-0.80.5-0.5
Incentive Sensitization - Responses0.91.32.2-1.3-1.3-1.5-1.4-1.3-1.2-1.2-1.1-1.1-1.2-0.9-0.9-0.9-1.2-0.9-1.3-1.00.5-0.4
Incentive Sensitization - Breakpoint1.01.32.2-1.3-1.3-1.5-1.4-1.3-1.2-1.2-1.2-1.1-1.2-1.0-1.0-1.0-1.2-1.0-1.3-1.00.5-0.5
Sum of active levers in priming session hrs 5-60.60.64.40.60.50.20.10.40.20.10.00.00.0-0.1-0.1-0.10.60.10.31.1-2.02.1
Progressive ratio0.50.81.10.70.81.01.00.80.90.80.90.90.81.01.01.00.81.00.90.9-0.50.4
Food seeking constrained by brief footshock0.20.20.8-0.4-0.4-0.4-0.3-0.4-0.3-0.3-0.4-0.4-0.3-0.4-0.4-0.4-0.5-0.4-0.3-0.60.9-0.9
Seeking ratio, punishment vs. effort0.30.50.7-0.5-0.6-0.8-0.8-0.6-0.6-0.7-0.7-0.7-0.7-0.8-0.8-0.8-0.7-0.8-0.7-0.70.5-0.4
Retroperitoneal fat weight2.410.412.7-3.3-3.4-3.6-3.5-3.3-3.5-3.4-3.4-3.4-3.5-3.5-3.5-3.5-3.2-3.3-3.3-2.61.6-1.5
Reaction time number correct0.30.63.00.70.60.40.40.60.40.50.50.50.50.20.20.20.70.60.51.0-1.71.7
Reaction time mean minus median0.00.10.30.10.30.50.50.30.40.10.10.30.20.40.40.40.30.30.40.30.2-0.2
Reaction time mean minus median AUC0.10.30.70.50.60.80.80.60.70.40.50.60.50.80.80.80.60.60.60.30.2-0.2
Reaction time num false alarms0.60.91.20.91.00.91.01.01.01.01.01.11.01.01.01.00.91.10.90.9-0.60.6
Reaction time num false alarms AUC0.40.70.90.80.90.80.90.80.80.80.80.90.80.90.90.90.90.90.80.8-0.60.6
Reaction time trials correct on left0.30.63.00.70.60.40.40.60.40.50.50.50.50.20.20.20.70.60.51.0-1.71.7
Reaction time trials on left0.30.52.70.60.60.30.30.50.40.50.50.40.40.20.20.20.60.50.50.9-1.61.6
Reaction time mean0.20.32.2-0.10.00.30.30.00.30.20.10.20.20.40.40.4-0.00.10.1-0.51.4-1.5
Reaction time mean AUC0.20.32.9-0.2-0.10.20.2-0.10.20.10.00.10.10.30.30.3-0.2-0.0-0.0-0.71.6-1.7
Median of all reaction times0.20.32.8-0.2-0.10.10.1-0.10.20.10.00.00.10.20.20.2-0.2-0.1-0.1-0.81.6-1.7
Reaction time omissions0.40.60.9-0.8-0.8-0.7-0.6-0.7-0.6-0.7-0.7-0.7-0.7-0.8-0.8-0.8-0.7-0.8-0.6-0.71.0-1.0
Reaction time false alarm rate0.40.61.00.70.80.90.90.80.90.80.80.90.81.01.01.00.70.90.80.50.1-0.2
Reaction time premature initiation rate1.01.41.7-1.2-1.2-1.2-1.2-1.2-1.2-1.3-1.3-1.3-1.3-1.3-1.3-1.3-1.2-1.2-1.2-1.10.8-0.7
Reaction time premature initiations0.51.01.5-0.9-1.0-1.1-1.1-1.0-1.1-1.1-1.1-1.1-1.1-1.2-1.2-1.2-0.9-1.0-1.0-0.6-0.10.2
Std. dev. reaction times0.10.21.3-0.00.10.40.40.10.50.20.20.20.20.40.40.40.10.20.3-0.21.1-1.1
Reaction time trials completed0.30.52.70.60.60.30.30.50.40.50.50.40.40.20.20.20.60.50.50.9-1.61.6
Reaction time trials AUC0.20.42.40.50.40.20.20.40.20.30.30.30.20.10.10.10.50.40.30.8-1.51.5
Run reversals in cocaine runway, females0.70.71.1-1.0-0.9-1.0-1.0-0.9-0.9-0.8-0.7-0.9-0.7-0.9-0.9-0.9-0.8-0.9-0.8-0.50.2-0.2
Run reversals in cocaine runway, males0.10.10.2-0.1-0.1-0.3-0.3-0.2-0.1-0.1-0.1-0.2-0.1-0.2-0.2-0.2-0.1-0.2-0.3-0.1-0.40.5
Latency to leave start box in cocaine runway1.21.31.9-1.3-1.3-1.4-1.3-1.3-1.3-1.3-1.3-1.0-1.3-1.0-1.0-1.0-1.2-0.9-1.3-1.00.7-0.6
Latency to leave start box in cocaine runway, F0.20.20.4-0.5-0.6-0.6-0.5-0.5-0.5-0.5-0.5-0.3-0.6-0.3-0.3-0.3-0.5-0.3-0.5-0.60.6-0.6
Latency to leave start box in cocaine runway, M3.63.44.5-2.0-1.9-2.1-2.1-1.9-2.0-2.0-2.0-1.9-2.0-1.8-1.8-1.8-1.9-1.8-2.0-1.50.8-0.7
Std. dev. time between licks in bursts1.52.12.81.51.31.21.21.41.21.71.61.61.61.51.51.51.31.61.31.3-1.41.3
Total sessions with >9 infusions0.10.10.50.40.30.10.20.30.30.30.30.40.30.30.30.30.40.40.20.4-0.70.7
Short access day 1 total inactive lever presses0.10.20.3-0.4-0.5-0.5-0.6-0.5-0.4-0.4-0.4-0.4-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.40.2-0.2
Short access day 10 total inactive lever presses0.10.20.4-0.4-0.4-0.4-0.6-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.5-0.4-0.4-0.40.3-0.3
Short access day 1 total infusions0.30.40.70.70.60.40.50.60.60.70.70.70.60.60.60.60.70.70.50.6-0.80.8
Short access day 10 total infusions0.00.00.10.10.1-0.0-0.10.10.20.30.30.30.20.30.30.30.10.30.10.00.1-0.1
Short access total infusions0.91.21.51.11.10.90.91.11.11.11.21.21.11.21.21.21.11.21.01.0-0.90.9
Short access day 1 locomotion0.10.10.20.40.40.20.40.30.40.50.40.40.40.20.20.20.40.30.30.3-0.30.3
Short access day 10 total locomotion0.30.60.90.80.80.80.80.80.90.90.80.91.00.90.90.90.70.90.80.30.1-0.2
Short access total locomotion0.60.70.90.90.90.70.80.90.90.90.90.80.90.80.80.80.90.80.80.8-0.70.7
One hour access (0.3 mA shock)0.30.31.20.30.40.30.50.40.40.30.40.50.40.50.50.50.60.60.40.8-1.11.1
Compulsive drug intake0.20.20.60.50.50.50.40.50.30.30.30.30.30.40.40.40.50.40.40.6-0.80.8
One hour access (shock baseline)0.20.30.5-0.7-0.7-0.7-0.6-0.7-0.6-0.6-0.6-0.5-0.6-0.5-0.5-0.5-0.6-0.5-0.6-0.50.4-0.4
Social response proportion1.01.11.70.80.81.01.11.01.11.31.31.21.21.21.21.20.91.11.20.9-0.20.1
Social responses2.12.74.41.31.31.61.61.51.61.81.81.91.72.12.12.11.51.91.81.5-0.60.6
Social time1.62.24.51.31.31.21.21.41.21.31.31.31.21.41.41.41.61.51.62.0-2.12.1
Soleus weight0.41.21.6-1.3-1.3-1.1-1.2-1.1-1.1-1.1-1.1-1.1-1.1-1.2-1.2-1.2-1.1-1.1-0.9-0.80.9-0.8
Bone: stiffness0.00.00.1-0.1-0.1-0.00.1-0.0-0.00.20.10.20.20.30.30.30.10.20.1-0.10.3-0.4
Tibialis anterior weight0.20.71.0-0.9-0.9-0.9-1.0-0.9-0.9-0.8-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.8-0.9-0.80.7-0.7
Time to tail flick, vehicle, before self-admin0.40.40.70.50.50.60.30.60.80.40.30.60.60.80.80.80.60.80.70.7-0.40.3
Time to tail flick, vehicle, after self-admin1.82.33.51.41.51.91.81.61.81.71.71.51.81.61.61.61.41.41.81.00.1-0.2
Time to tail flick, test, before self-admin4.44.56.72.12.01.92.02.12.02.11.92.02.02.02.02.02.22.12.12.4-2.62.6
Time to tail flick, test, after self-admin1.21.32.31.11.21.31.51.21.11.11.01.01.11.01.01.01.31.01.21.1-0.90.8
Delta time to tail flick, vehicle, before/after SA0.60.61.40.80.81.01.20.80.81.01.00.70.90.60.60.60.70.50.90.5-0.10.0
Delta time to tail flick, test, before/after SA1.31.45.1-1.1-1.0-0.6-0.6-1.0-0.9-1.0-1.0-0.9-0.8-0.9-0.9-0.9-1.1-1.0-0.9-1.52.2-2.3
Tibia length2.67.38.9-2.7-2.8-2.8-2.7-2.8-2.9-3.0-3.0-3.0-3.0-3.0-3.0-3.0-2.6-2.8-2.7-2.11.4-1.3
Ambulatory time before self-admin0.20.20.80.40.40.30.20.40.40.40.50.30.30.40.40.40.50.40.40.7-0.90.9
Ambulatory time after self-admin1.82.12.7-1.4-1.4-1.6-1.5-1.5-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.4-1.5-1.6-1.20.4-0.4
Bone: tissue strength0.10.10.20.20.20.40.40.30.30.20.20.10.20.20.20.20.40.20.30.4-0.20.2
Total heroin consumption0.10.20.6-0.5-0.5-0.7-0.6-0.5-0.3-0.0-0.1-0.2-0.2-0.4-0.4-0.4-0.4-0.3-0.5-0.4-0.20.2
Bone: trabecular number0.50.91.30.70.80.91.00.81.01.11.11.11.11.01.01.00.91.01.00.50.3-0.4
Bone: trabecular spacing0.30.40.6-0.5-0.5-0.7-0.8-0.5-0.7-0.7-0.8-0.8-0.8-0.7-0.7-0.7-0.6-0.7-0.6-0.1-0.50.6
Bone: trabecular thickness0.91.11.60.91.01.11.21.01.11.21.21.21.21.31.31.31.01.21.00.50.1-0.2
Bone: trabecular tissue density0.60.85.50.80.80.30.20.70.30.30.30.30.40.30.30.30.60.40.41.2-2.32.3
Water consumed over 24 hours2.43.33.9-1.9-1.9-1.9-1.8-1.9-1.9-2.0-2.0-2.0-2.0-2.0-2.0-2.0-1.7-1.9-1.8-1.40.9-0.8
Number of responses in last shaping day0.00.00.0-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.1-0.0-0.1-0.10.0-0.20.2