Hub : Genes

Pex5l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Pex5l 0.04 0.02 6.5e-06 0.03 0.04 0.03 0.03 1.5e-04 1.6e-05 1.7e-04 2.2e-04
2 pVTA gene expression Pex5l 0.11 0.08 2.0e-04 0.05 0.07 0.02 0.04 4.6e-03 6.3e-04 3.6e-02 6.3e-03
3 PL isoform ratio NM_173152.3 0.03 0.02 8.8e-05 0.05 0.04 0.04 0.04 5.4e-06 6.8e-05 6.7e-05 6.7e-05
4 NAcc mRNA stability Pex5l 0.02 0.01 5.5e-03 0.02 0.01 0.01 0.01 4.7e-03 6.5e-03 4.4e-02 2.2e-02
5 BLA mRNA stability Pex5l 0.07 0.05 2.5e-04 0.06 0.07 0.07 0.07 2.2e-04 2.0e-04 1.6e-04 2.0e-04
6 PL mRNA stability Pex5l 0.02 0.01 7.2e-04 0.01 0.03 0.02 0.02 1.2e-02 3.3e-04 3.8e-03 2.0e-03
7 Brain gene expression Pex5l 0.06 0.03 3.2e-07 0.09 0.07 0.06 0.08 2.5e-08 5.2e-07 1.3e-06 5.3e-08
8 pVTA mRNA stability Pex5l 0.09 0.06 4.8e-04 0.07 0.05 0.03 0.05 4.0e-04 3.2e-03 2.0e-02 4.4e-03
9 Brain mRNA stability Pex5l 0.1 0.05 1.3e-07 0.08 0.08 0.07 0.08 9.1e-08 7.5e-08 2.9e-07 9.0e-08
10 IL gene expression Pex5l 0.55 0.17 7.9e-07 0.23 0.25 0.23 0.22 2.4e-06 1.1e-06 2.5e-06 4.1e-06
11 Brain isoform ratio NM_001393825.1 0.05 0.03 3.2e-03 0.04 0.03 0.01 0.02 9.6e-05 1.9e-03 8.1e-02 2.5e-03
12 BLA gene expression Pex5l 0.36 0.12 2.0e-13 0.19 0.26 0.25 0.25 2.3e-10 3.4e-14 1.7e-13 1.2e-13
13 Brain isoform ratio NM_173152.3 0.06 0.04 2.5e-04 0.05 0.03 0.04 0.05 1.0e-05 4.1e-04 2.1e-04 3.7e-05
14 BLA isoform ratio NM_173152.3 0.15 0.09 2.0e-03 0.02 0.04 0.03 0.04 2.8e-02 2.8e-03 8.5e-03 4.0e-03
15 OFC gene expression Pex5l 0.3 0.15 1.2e-03 0.17 0.13 0.18 0.16 9.4e-05 6.9e-04 4.0e-05 1.1e-04
16 PL gene expression Pex5l 0.2 0.09 1.2e-15 0.15 0.14 0.16 0.15 1.8e-16 3.2e-15 3.7e-17 2.7e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density2.64.47.9-2.7-2.8-2.8-2.6-2.62.62.5-2.51.80.9-0.00.3-1.51.9-1.4-1.2
Area under the delay curve0.70.81.5-1.2-1.0-1.0-1.2-1.21.01.1-1.11.1-0.2-0.9-0.3-0.70.00.40.2
BMI with tail0.93.06.1-1.9-2.0-1.8-1.5-1.51.91.6-1.40.02.11.51.8-1.32.5-1.8-2.1
BMI without tail1.22.54.6-2.1-2.0-2.1-1.9-2.02.01.8-1.71.01.10.30.8-1.01.6-0.8-1.2
Body weight0.21.03.4-0.4-0.5-0.6-0.1-0.10.40.1-0.0-0.81.41.61.4-0.31.8-1.3-1.5
Weight adjusted by age0.91.02.11.41.21.31.31.3-1.3-0.41.3-0.8-0.60.1-0.41.5-0.4-0.50.5
Bone surface0.20.43.5-0.4-0.7-0.5-0.5-0.50.50.6-0.40.30.10.1-0.20.00.6-1.9-0.3
Bone volume0.40.83.1-0.9-1.0-1.3-0.9-0.90.70.9-0.80.9-0.1-0.2-0.40.11.0-1.8-0.3
Breakpoint value in progressive ratio session3.53.97.4-2.1-2.2-1.7-1.8-1.72.31.6-1.8-0.02.41.62.1-2.72.1-1.0-2.7
Number of licking bursts1.61.93.7-1.7-1.6-1.6-1.3-1.31.60.1-1.20.21.71.01.6-1.91.6-0.0-1.5
Context. condit. distance diff. score2.83.49.1-2.5-2.2-3.0-2.3-2.32.02.5-2.32.10.1-0.5-0.4-0.81.6-0.5-0.4
Locomotion velocity, session 12.02.26.41.10.71.31.31.3-0.6-1.61.4-2.51.82.42.1-0.90.9-0.1-1.2
Locomotion distance, session 10.91.13.20.40.10.80.60.60.0-0.70.6-1.71.71.71.8-0.90.9-0.6-1.4
Locomotion velocity, session 23.23.710.90.90.70.91.51.5-0.7-1.71.7-3.12.53.33.0-1.31.9-0.6-2.0
Locomotion distance, session 21.11.63.90.70.50.71.01.0-0.5-1.11.2-1.91.62.01.8-0.31.3-1.2-1.5
Locomotion velocity, session 30.10.20.70.1-0.10.30.10.10.1-0.10.0-0.50.60.40.6-0.30.4-0.8-0.6
Locomotion distance, session 30.20.20.40.30.40.30.50.5-0.3-0.50.5-0.70.50.50.6-0.30.20.4-0.4
Stereotopy head waving bouts, day 30.10.10.40.30.20.50.40.4-0.2-0.20.3-0.60.40.60.5-0.00.20.0-0.3
Stereotopy head waving duration, day 30.30.40.9-0.7-0.9-0.3-0.8-0.81.00.8-0.80.30.60.10.4-0.80.2-0.4-0.5
Locomotion velocity, session 71.11.25.40.60.30.60.80.8-0.4-0.70.8-1.41.21.41.1-0.21.3-2.3-1.3
Locomotion distance, session 70.30.40.80.60.6-0.00.70.7-0.8-0.70.9-0.60.10.50.20.40.8-0.8-0.5
Stereotopy head waving bouts, day 71.61.83.1-1.6-1.4-1.4-1.1-1.11.51.4-1.20.01.81.21.6-1.41.7-0.0-1.7
Stereotopy head waving duration, day 71.72.03.6-1.6-1.6-1.2-1.2-1.21.71.4-1.3-0.11.91.31.7-1.61.6-0.4-1.7
Locomotion velocity, session 82.12.53.8-2.0-1.9-1.9-1.6-1.61.91.6-1.60.41.60.91.4-1.81.9-0.7-1.4
Locomotion distance, session 81.01.43.7-1.4-1.4-1.9-1.1-1.11.11.3-1.00.60.80.60.5-0.41.9-1.6-1.0
Degree of sensitization distance0.50.51.60.80.90.10.80.8-1.1-0.70.9-0.2-0.8-0.0-0.71.30.1-0.60.3
Degree of sensitization stereotypy1.61.82.9-1.7-1.6-1.5-1.3-1.31.71.5-1.50.41.40.81.3-1.41.30.2-1.3
Conditioned locomotion0.50.62.00.00.3-0.40.00.0-0.40.2-0.11.1-1.4-1.1-1.41.2-0.70.11.1
Cocaine response after cond. corrected1.51.74.80.40.80.10.10.1-0.8-0.20.11.2-2.2-1.9-2.01.5-1.81.22.1
Cocaine response after cond. not corrected2.02.25.21.11.21.00.60.6-1.2-0.90.60.8-2.3-2.0-2.01.7-2.31.02.3
Cocaine response before conditioning0.20.21.20.4-0.11.1-0.0-0.00.2-0.40.1-0.50.50.10.2-0.4-0.5-1.0-0.2
Saline control response0.50.72.11.20.81.40.80.8-0.8-1.00.9-0.8-0.20.1-0.30.5-0.7-0.90.5
Bone: connectivity density1.52.44.3-2.0-2.1-1.7-1.8-1.82.01.8-1.80.81.20.50.8-1.61.4-0.9-1.2
Bone: cortical apparent density0.20.31.2-0.5-0.4-1.1-0.2-0.20.30.4-0.20.00.40.60.4-0.21.1-0.1-0.5
Bone: cortical area0.20.32.7-0.1-0.3-0.3-0.4-0.30.10.2-0.20.5-0.5-0.4-0.80.60.3-1.60.2
Bone: cortical porosity0.91.05.20.50.21.6-0.3-0.30.1-0.4-0.30.6-0.9-1.8-1.20.2-2.3-0.31.0
Bone: cortical porosity0.80.94.30.50.01.6-0.3-0.30.1-0.3-0.30.6-0.8-1.7-1.20.2-2.1-0.80.9
Bone: cortical thickness0.40.72.5-0.1-0.3-0.1-0.7-0.70.20.3-0.61.2-1.2-1.5-1.60.6-0.9-0.71.0
Bone: cortical thickness0.60.72.10.10.10.30.40.40.0-0.50.5-1.21.31.31.5-1.10.8-0.4-1.1
Bone: cortical tissue density0.20.31.5-0.6-0.5-1.2-0.2-0.20.30.5-0.2-0.00.50.70.5-0.21.2-0.1-0.6
Condit. Reinf. active minus inactive responses1.21.32.51.61.31.61.61.6-1.3-1.41.4-1.50.00.90.30.4-0.4-0.10.3
Condit. Reinf. active-inactive response ratio1.31.42.51.61.51.51.41.4-1.5-1.31.3-0.7-1.0-0.2-0.71.3-1.20.51.1
Condit. Reinf. active responses1.21.54.41.00.51.41.11.1-0.5-1.11.0-2.11.42.01.5-0.90.7-1.3-0.8
Condit. Reinf. inactive responses2.02.46.2-0.4-1.10.2-0.3-0.31.10.1-0.3-1.62.52.22.2-2.31.8-2.1-1.9
Incentive salience index mean1.31.63.01.71.51.71.71.7-1.4-1.61.6-1.60.11.00.30.4-0.4-0.10.3
Condit. Reinf. lever presses0.60.82.21.10.61.41.00.9-0.6-1.00.9-1.50.71.10.8-0.50.1-0.6-0.3
Condit. Reinf. active minus inactive responses0.81.02.91.41.11.71.21.2-1.1-1.41.2-1.0-0.30.2-0.20.3-0.9-0.40.5
Condit. Reinf. active-inactive response ratio1.21.31.81.31.41.21.21.2-1.3-1.11.1-0.2-1.3-0.8-1.11.2-1.30.61.2
Condit. Reinf. active responses1.72.35.42.01.42.31.91.9-1.4-2.11.9-2.20.51.40.7-0.0-0.3-1.0-0.1
Condit. Reinf. inactive responses1.51.85.51.30.81.71.31.3-0.7-1.51.4-2.31.32.01.6-0.90.4-0.6-0.8
Condit. Reinf. lever presses0.10.20.60.50.30.70.40.4-0.3-0.70.4-0.4-0.00.2-0.10.3-0.2-0.80.0
Condit. Reinf. lever reinforcers received1.52.24.81.91.32.11.81.8-1.3-2.01.8-2.20.61.50.8-0.1-0.0-1.2-0.2
Conditioned reinforcement - actives0.40.41.30.70.70.70.70.7-0.6-1.20.8-0.60.00.20.2-0.3-0.31.10.1
Conditioned reinforcement - inactives0.10.10.70.00.00.00.00.0-0.0-0.30.2-0.20.20.30.2-0.60.10.8-0.2
Conditioned locomotion1.51.86.00.40.10.80.70.7-0.0-0.70.8-2.12.02.52.2-1.61.3-0.3-1.6
Patch foraging indifference point 0 sec1.22.03.7-1.9-1.7-1.9-1.6-1.61.71.6-1.50.71.20.50.9-1.31.6-0.4-1.2
Patch foraging indifference point AUC1.41.64.9-1.1-1.3-0.4-1.0-1.01.60.9-1.0-0.31.90.91.7-2.20.7-0.9-1.6
Delay disc. indifference point, 0s delay0.30.30.80.50.40.30.50.6-0.4-0.50.6-0.90.40.90.5-0.50.4-0.3-0.4
Delay disc. indifference point, 16s delay1.01.01.8-1.3-1.2-1.2-1.3-1.31.21.3-1.31.10.1-0.6-0.1-1.00.4-0.2-0.1
Delay disc. indifference point, 2s delay0.40.41.2-0.8-0.8-0.8-1.1-1.00.70.7-0.80.8-0.1-0.5-0.3-0.40.2-0.20.1
Delay disc. indifference point, 24s delay0.90.91.7-1.3-1.1-1.3-1.2-1.31.11.3-1.21.2-0.0-0.7-0.2-0.10.5-0.2-0.1
Delay disc. indifference point, 4s delay0.20.21.2-0.4-0.5-0.2-0.6-0.50.50.3-0.40.00.40.20.4-1.10.10.4-0.2
Delay disc. indifference point, 8s delay0.30.31.0-0.4-0.2-0.3-0.4-0.40.20.3-0.50.8-0.7-1.0-0.6-0.1-0.50.80.7
Indifference point function ln k1.52.16.21.21.60.31.21.1-1.8-1.01.10.5-2.2-1.1-1.92.5-0.91.11.8
Indifference point function log k1.52.16.21.21.60.31.21.1-1.8-1.01.10.5-2.2-1.1-1.92.5-0.91.11.8
Patch foraging total patch changes 0 sec1.11.83.3-1.8-1.7-1.8-1.6-1.61.71.6-1.50.81.10.40.8-1.31.4-0.2-1.0
Patch foraging total patch changes 12 sec1.31.63.3-1.7-1.7-1.3-1.7-1.71.81.4-1.50.81.0-0.10.7-1.50.5-0.6-0.9
Patch foraging total patch changes 18 sec1.11.53.3-1.5-1.4-1.1-1.2-1.21.51.3-1.20.31.40.71.2-1.81.0-0.2-1.1
Patch foraging total patch changes 24 sec4.75.89.5-2.9-3.1-2.5-2.8-2.73.12.6-2.60.92.40.91.8-2.72.3-1.5-2.3
Patch foraging total patch changes 6 sec3.24.79.2-2.8-2.9-2.1-2.7-2.83.02.7-2.71.41.6-0.01.1-2.61.1-0.6-1.4
Patch foraging time to switch 0 sec0.10.20.70.20.3-0.30.20.2-0.5-0.00.30.4-0.8-0.4-0.70.8-0.20.50.7
Patch foraging water rate 0 sec0.30.51.0-0.9-0.9-0.7-1.0-1.00.90.9-1.00.70.2-0.4-0.0-0.40.2-0.2-0.2
Patch foraging water rate 12 sec0.00.00.10.20.20.30.00.1-0.2-0.1-0.10.1-0.2-0.2-0.30.3-0.3-0.10.1
Patch foraging water rate 18 sec0.20.30.90.20.20.30.30.4-0.1-0.60.4-0.90.61.00.8-0.20.40.2-0.4
Patch foraging water rate 24 sec2.23.16.0-1.9-2.1-2.0-1.5-1.62.01.5-1.50.12.01.41.7-1.82.5-1.6-1.8
Patch foraging water rate 6 sec0.00.00.1-0.1-0.10.1-0.2-0.20.2-0.0-0.2-0.10.20.30.2-0.3-0.10.20.0
Seeking ratio, delayed vs. immediate footshock0.40.40.8-0.8-0.9-0.6-0.9-0.90.80.9-0.80.50.4-0.10.1-0.40.5-0.5-0.4
Distance traveled before self-admin1.71.83.2-1.7-1.7-1.7-1.7-1.71.61.8-1.71.20.6-0.40.2-0.81.0-1.3-0.9
Distance traveled after self-admin0.91.02.4-1.0-1.0-0.8-0.8-0.81.01.1-0.9-0.01.20.61.0-1.51.0-0.8-1.6
Extensor digitorum longus weight0.83.07.9-1.0-1.5-0.5-0.7-0.71.40.1-0.4-1.32.82.52.5-2.12.4-2.0-2.4
Bone: elastic displacement0.60.71.90.20.40.0-0.1-0.1-0.4-0.1-0.00.9-1.4-1.4-1.30.9-1.11.01.1
Bone: elastic work0.81.02.71.00.90.60.60.6-1.1-0.70.70.3-1.6-0.9-1.61.7-0.9-0.21.3
Bone: endosteal estimation0.71.57.90.60.20.10.80.8-0.5-0.61.0-1.51.11.71.10.21.8-2.8-1.2
Bone: endosteal perimeter0.30.61.21.00.80.91.01.0-0.8-0.91.1-1.10.30.70.40.50.3-0.9-0.2
Epididymis fat weight0.51.12.11.21.01.01.31.3-1.1-1.21.3-1.50.41.20.61.00.4-0.6-0.2
Delta time in closed arm before/after self-admin0.60.65.1-0.5-0.7-0.6-0.6-0.60.60.2-0.60.30.30.10.00.60.7-2.3-0.7
Delta time in open arm before/after self-admin1.11.05.90.81.20.90.90.9-1.0-0.30.9-0.1-0.9-0.7-0.50.2-1.32.40.9
Diff in mean of infusions in LGA sessions0.40.42.6-0.5-0.6-0.5-0.7-0.50.51.2-0.60.40.1-0.0-0.10.30.5-1.6-0.5
Delay discount exponential model param0.80.91.71.21.01.01.31.3-1.1-1.11.2-1.20.21.00.30.70.1-0.4-0.3
Extinction: sum of active levers before priming0.10.10.50.30.10.20.20.2-0.20.20.1-0.40.20.40.1-0.40.3-0.7-0.7
Active lever presses in extinction session 60.20.21.0-0.3-0.4-0.2-0.4-0.20.4-0.4-0.3-0.10.60.40.5-0.40.5-0.3-1.0
Bone: final force0.40.76.90.6-0.00.60.30.3-0.2-0.60.5-0.80.50.70.30.20.7-2.6-0.6
Bone: final moment0.30.56.30.3-0.20.30.10.1-0.0-0.30.2-0.40.30.4-0.00.20.7-2.5-0.4
Food consumed during 24 hour testing period0.10.10.6-0.2-0.0-0.60.10.1-0.1-0.30.10.10.10.10.10.60.8-0.6-0.4
Glucose1.42.13.61.71.91.41.51.5-1.8-1.81.6-0.4-1.4-0.7-1.01.7-1.50.61.2
Heart weight0.20.30.9-0.6-0.9-0.2-0.6-0.70.90.7-0.70.20.40.40.2-1.00.2-0.5-0.1
Delay discount hyperbolic model param0.60.61.31.00.90.81.11.1-0.9-0.91.0-1.10.20.80.30.60.1-0.4-0.3
Intermittent access intake day 1-15 change0.80.81.7-1.0-1.0-0.8-0.8-0.81.10.2-0.7-0.11.30.81.2-1.11.0-0.3-1.2
Intermittent access intake escalation0.40.40.9-0.7-0.6-0.5-0.5-0.50.80.4-0.6-0.10.90.70.9-0.90.50.1-0.8
Intermittent access intake escalation 20.20.20.60.20.10.40.30.3-0.0-0.30.2-0.70.70.70.80.10.3-0.5-0.6
Intermitt. access day 1 inactive lever presses0.00.10.40.20.10.10.10.1-0.2-0.60.3-0.3-0.10.3-0.00.10.0-0.10.1
Intermitt. access day 15 inactive lever presses0.60.73.70.80.90.90.90.9-0.7-0.50.9-0.8-0.00.50.3-0.5-0.71.90.3
Intermitt. access escalation Index0.10.00.10.30.30.30.30.3-0.3-0.10.2-0.0-0.1-0.1-0.10.2-0.20.20.0
Intermittent access day 1 total infusions2.73.15.22.32.22.32.32.3-2.1-2.22.2-1.8-0.50.70.00.4-1.12.00.7
Intermittent access day 15 total infusions0.91.02.60.50.50.90.90.9-0.3-0.80.8-1.51.11.61.4-1.30.31.3-0.7
Intermittent access terminal intake (last 3 days)2.02.25.01.51.41.71.71.7-1.2-1.81.7-2.21.01.81.5-0.60.01.3-0.6
Intermittent access total infusions1.92.14.91.41.31.71.71.7-1.1-1.71.6-2.21.01.91.5-0.80.01.5-0.5
Intermittent access day 1 locomotion0.90.92.01.10.91.21.21.2-0.8-1.11.0-1.40.41.20.7-0.6-0.11.0-0.1
Intermittent access day 15 total locomotion2.32.57.6-1.2-1.4-0.8-0.8-0.81.50.8-0.9-0.92.32.12.2-2.81.9-0.2-2.0
Intermittent access total locomotion1.82.17.0-0.1-0.30.30.30.30.5-0.40.3-1.92.32.72.5-2.11.50.1-1.7
Intermittent access standard deviation0.10.10.2-0.4-0.3-0.3-0.3-0.30.30.3-0.40.30.0-0.2-0.0-0.30.00.3-0.1
Left kidney weight0.10.31.0-0.6-0.6-1.0-0.5-0.50.40.8-0.60.6-0.10.2-0.30.30.9-0.3-0.1
Right kidney weight0.51.33.0-1.3-1.3-1.4-1.0-1.01.21.1-1.00.21.21.01.0-1.01.7-0.6-1.2
Cocaine induced anxiety0.60.61.80.50.40.70.70.7-0.3-1.20.7-1.20.91.31.1-0.60.40.2-0.7
Post-drug Anxiety1.21.32.91.21.11.41.41.4-1.0-1.71.4-1.60.61.31.00.2-0.10.5-0.2
Baseline Anxiety0.30.41.2-0.5-0.4-0.6-0.6-0.60.41.1-0.60.9-0.5-0.9-0.60.2-0.3-0.10.4
Tail length0.10.41.0-0.2-0.0-0.5-0.4-0.4-0.00.2-0.20.9-1.0-1.0-1.00.8-0.50.20.8
Length with tail0.20.71.80.91.00.50.70.7-1.1-0.80.80.0-1.1-0.6-1.01.3-0.60.30.9
Length without tail0.71.53.01.71.41.21.71.7-1.7-1.41.6-1.1-0.40.6-0.31.40.2-1.10.2
Times rat made contact with spout0.60.71.90.91.20.41.21.2-1.2-1.41.2-0.7-0.20.30.11.00.20.3-0.1
Lifetime Intake2.02.34.71.71.61.91.91.9-1.4-1.91.9-2.20.71.71.2-0.2-0.21.4-0.3
Liver weight, left1.01.63.41.11.40.61.71.7-1.3-1.41.7-1.90.71.71.30.10.80.6-0.5
Liver weight, right0.10.20.50.40.40.40.60.6-0.4-0.30.5-0.60.30.70.40.30.20.2-0.3
Locomotor activity2.13.37.92.62.02.82.01.9-2.0-2.32.0-1.3-1.1-0.1-0.91.8-1.8-0.91.3
Locomotor testing distance0.81.45.31.71.02.31.21.2-0.9-1.41.3-1.50.20.70.20.3-0.9-1.30.2
Locomotor testing rearing0.10.21.30.70.31.10.20.3-0.3-0.40.3-0.60.00.2-0.10.0-0.5-0.80.3
Locomotion in novel chamber0.70.82.20.30.30.60.60.6-0.1-1.00.7-1.31.21.41.5-1.10.60.9-0.9
Locomotion in novel chamber post-restriction0.20.20.7-0.2-0.3-0.1-0.3-0.30.20.2-0.40.7-0.6-0.8-0.70.6-0.3-0.50.4
Fecal boli incidents, locomotor time 11.41.52.81.31.51.21.21.1-1.5-1.21.2-0.2-1.4-0.5-1.01.0-1.31.71.5
Change in fecal boli incidents, locomotor task0.80.81.7-0.9-1.0-0.4-0.9-0.81.00.4-0.7-0.21.30.81.1-1.01.0-0.6-1.1
Time >=10cm from walls, locomotor time 10.10.10.50.30.30.20.30.2-0.4-0.20.20.2-0.5-0.5-0.50.7-0.3-0.30.2
Bouts of movement, locomotor time 10.30.31.00.50.40.10.40.4-0.5-0.00.30.3-0.9-0.6-1.00.6-0.6-0.40.5
Total resting periods, locomotor time 10.70.72.20.60.70.30.30.4-0.8-0.20.30.6-1.5-1.2-1.51.0-1.20.41.1
Rest time, locomotor task time 10.70.81.41.11.21.00.91.1-1.1-1.21.1-0.7-0.60.1-0.30.3-0.81.00.8
Distance moved, locomotor task time 11.21.32.2-1.2-1.3-1.1-1.0-1.01.31.1-1.00.11.40.71.1-0.81.4-1.3-1.5
Vertical activity count, locomotor time 11.01.01.7-1.3-1.3-1.2-1.0-1.11.21.0-1.00.60.90.20.6-0.41.2-1.0-1.2
Time >=10cm from walls, locomotor time 20.10.10.50.40.50.20.20.2-0.5-0.70.7-0.1-0.3-0.3-0.20.4-0.30.30.1
Bouts of movement, locomotor time 20.80.83.3-0.10.1-0.6-0.3-0.2-0.10.5-0.21.3-1.5-1.8-1.60.6-1.20.41.0
Total resting periods, locomotor time 20.80.83.20.10.3-0.3-0.10.0-0.30.3-0.01.2-1.5-1.8-1.60.6-1.40.51.1
Rest time, locomotor task time 20.10.10.4-0.1-0.0-0.1-0.2-0.20.00.2-0.30.4-0.5-0.6-0.5-0.0-0.4-0.10.5
Distance moved, locomotor task time 20.50.61.70.1-0.10.20.20.20.1-0.30.6-1.11.31.31.3-0.60.8-0.5-1.2
Vertical activity count, locomotor time 20.91.02.50.70.60.81.00.9-0.5-1.11.1-1.61.21.61.4-0.50.50.6-0.9
Light reinforcement 10.50.81.71.00.70.90.50.6-0.9-1.00.70.1-1.1-0.8-1.31.3-1.0-0.91.0
Light reinforcement 20.00.10.20.20.2-0.00.40.3-0.3-0.50.2-0.2-0.10.40.10.40.20.10.1
Bone: marrow area0.71.57.50.40.0-0.10.70.7-0.4-0.40.8-1.41.21.81.20.12.0-2.7-1.3
Bone: maximum diameter0.10.21.7-0.1-0.4-0.3-0.3-0.30.20.2-0.10.00.10.1-0.10.00.6-1.3-0.1
Bone: maximum force0.30.53.90.80.40.50.50.5-0.6-0.80.7-0.5-0.30.2-0.40.80.2-2.00.2
Bone: maximum moment0.30.43.50.70.30.30.40.4-0.6-0.60.6-0.2-0.5-0.0-0.70.80.1-1.90.4
Mean time between licks in bursts1.31.94.61.31.40.71.01.0-1.6-0.01.00.4-2.1-1.3-1.92.1-1.40.51.9
Mean num. licks in bursts1.92.34.41.92.01.71.71.7-2.0-0.51.6-0.4-1.6-0.9-1.42.1-1.60.31.3
Cd content in liver1.01.02.71.41.21.71.31.3-1.1-0.21.3-1.3-0.00.60.30.3-0.91.00.4
Co content in liver0.40.41.20.60.60.80.70.7-0.4-0.50.7-1.10.60.90.8-0.3-0.10.6-0.2
Cu content in liver0.40.40.90.60.80.20.70.7-0.9-0.60.6-0.0-0.8-0.4-0.61.0-0.50.90.6
Fe content in liver1.21.54.01.21.31.50.90.9-1.1-0.90.9-0.0-1.4-1.0-1.10.8-2.01.51.4
K content in liver1.01.02.4-1.0-0.9-1.2-1.1-1.10.70.9-1.21.6-0.7-1.2-1.10.60.2-1.10.3
Mg content in liver1.31.44.1-0.4-0.3-0.9-0.7-0.70.00.4-0.71.8-1.7-2.0-2.01.5-0.6-1.01.1
Mn content in liver0.80.93.0-0.2-0.1-0.6-0.5-0.5-0.1-0.5-0.61.5-1.5-1.7-1.70.8-0.80.41.2
Na content in liver1.31.42.2-1.5-1.5-1.3-1.2-1.31.51.2-1.30.41.20.60.9-1.31.3-0.7-1.2
Rb content in liver0.30.31.3-0.1-0.20.5-0.4-0.40.30.7-0.40.7-0.6-0.9-0.70.0-1.10.50.7
Se content in liver0.80.92.61.31.11.61.21.2-1.0-1.31.1-1.10.10.30.30.1-0.90.60.2
Sr content in liver1.01.03.3-0.5-0.5-0.0-0.1-0.10.70.2-0.1-0.91.61.41.7-1.80.80.4-1.2
Zn content in liver0.70.82.5-0.10.2-0.7-0.2-0.2-0.40.0-0.21.4-1.5-1.5-1.51.6-0.50.40.8
Bone: minimum diameter0.40.82.91.10.70.40.80.8-1.1-0.81.0-0.2-0.9-0.2-1.11.40.1-1.70.7
Time in familiar zone, hab. session 10.30.21.00.30.50.20.50.5-0.4-0.50.5-0.60.30.60.6-0.20.21.0-0.2
Time in novel zone, hab. session 11.71.73.3-1.5-1.7-1.1-1.8-1.81.71.5-1.71.40.2-0.9-0.4-0.90.2-1.3-0.3
Total zone transitions, hab. session 10.50.81.6-0.8-1.1-0.2-0.9-0.91.20.8-0.90.01.10.40.7-1.00.6-1.3-0.9
Total locomotion distance, hab. session 11.92.75.0-1.8-2.2-1.0-2.0-2.02.21.9-2.00.81.40.10.7-1.71.0-2.2-1.3
Locomotion velocity, hab. session 11.62.34.5-1.6-2.1-0.8-1.9-1.92.11.7-1.90.71.3-0.00.6-1.50.9-2.1-1.2
Time in familiar zone, hab. session 20.70.72.50.70.61.00.20.2-0.5-0.50.20.3-1.1-1.0-1.10.5-1.60.91.3
Time in novel zone, hab. session 21.61.62.9-1.5-1.5-1.6-1.2-1.21.41.4-1.20.41.20.60.9-0.81.7-1.5-1.4
Total zone transitions, hab. session 20.20.31.00.0-0.20.30.10.10.2-0.10.1-0.71.00.81.0-0.60.5-0.5-0.8
Total locomotion distance, hab. session 20.20.20.7-0.2-0.50.3-0.3-0.30.60.3-0.4-0.30.80.30.6-0.70.2-0.6-0.6
Locomotion velocity, hab. session 20.20.31.0-0.1-0.40.5-0.1-0.10.40.1-0.1-0.61.00.60.8-0.70.3-0.8-0.8
Novel to familiar place preference ratio4.64.89.1-2.8-2.7-2.6-3.0-3.02.73.0-2.92.70.0-1.5-0.6-1.30.4-0.2-0.3
Novelty place preference6.06.111.4-3.2-3.1-2.9-3.4-3.43.03.4-3.33.10.1-1.7-0.7-1.40.5-0.3-0.4
Time in novel zone, NPP test6.66.812.6-3.4-3.2-3.1-3.6-3.63.23.5-3.53.20.1-1.8-0.7-1.50.7-0.5-0.4
Total zone transitions, NPP test1.11.64.51.10.71.41.21.2-0.6-1.31.3-2.11.41.81.6-0.80.6-0.6-1.1
Total locomotion distance, NPP test0.40.61.70.70.41.10.60.6-0.3-0.80.7-1.31.01.01.0-0.50.2-0.6-0.7
Locomotion velocity, NPP test0.60.92.21.00.61.50.90.9-0.5-1.11.0-1.50.91.00.9-0.3-0.0-0.8-0.6
Intraocular pressure0.81.11.91.41.31.41.31.3-1.2-1.21.2-0.9-0.50.2-0.20.6-0.90.70.7
Delta distance traveled before/after self-admin0.80.91.61.11.11.31.21.3-1.0-0.91.2-1.30.20.90.6-0.1-0.30.9-0.1
Delta ambulatory time before/after self-admin0.60.71.40.80.81.00.91.0-0.7-0.81.0-1.20.51.00.8-0.5-0.10.8-0.4
Parametrial fat weight0.61.24.5-0.1-0.2-0.40.50.50.0-0.10.3-1.31.52.01.6-0.52.1-1.3-1.3
Pavlov. Cond. lever latency0.81.02.1-1.2-1.2-1.0-1.3-1.31.21.3-1.41.4-0.3-0.9-0.6-0.3-0.1-0.20.1
Pavlov. Cond. magazine entry latency0.10.20.7-0.3-0.2-0.6-0.1-0.10.10.3-0.1-0.10.40.40.4-0.40.9-0.4-0.6
Pavlov. Cond. change in total contacts0.30.30.60.60.60.60.70.7-0.6-0.60.7-0.70.20.60.4-0.3-0.10.80.1
Pavlov. Cond. index score0.70.92.90.30.30.20.70.7-0.3-0.60.8-1.51.31.71.5-0.91.2-0.0-1.1
Pavlov. Cond. latency score0.70.92.30.70.70.51.11.0-0.7-0.91.1-1.51.01.51.2-0.40.8-0.1-0.8
Pavlov. Cond. lever contacts1.01.22.81.11.00.81.31.3-1.0-1.21.4-1.70.81.51.0-0.10.7-0.4-0.6
Pavlov. Cond. magazine entry number1.01.33.90.80.61.10.20.2-0.6-0.50.20.7-1.6-1.7-1.71.4-2.0-0.21.5
Pavlov. Cond. intertrial magazine entries0.70.82.00.80.90.90.60.6-0.8-0.40.50.3-1.3-1.1-1.21.0-1.40.71.2
Pavlov. Cond. lever-magazine prob. diff.0.60.82.40.20.20.00.60.6-0.2-0.40.6-1.21.31.51.4-0.91.2-0.2-1.1
Pavlov. Cond. response bias1.01.34.0-0.6-0.5-0.90.00.00.40.3-0.0-1.01.71.91.8-1.42.0-0.2-1.5
Pavlov. Cond. lever latency0.20.30.90.40.6-0.10.50.5-0.7-0.10.40.2-0.8-0.4-0.71.0-0.20.80.7
Pavlov. Cond. magazine entry latency0.20.32.3-0.5-0.2-1.0-0.1-0.10.10.2-0.10.30.00.40.20.10.51.5-0.0
Pavlov. Cond. change in total contacts0.40.61.80.90.71.30.90.9-0.5-1.10.9-1.10.40.50.6-0.3-0.5-0.1-0.1
Pavlov. Cond. index score0.30.31.0-0.4-0.4-0.3-0.1-0.10.50.0-0.1-0.40.91.01.0-0.80.70.2-0.7
Pavlov. Cond. latency score0.20.30.9-0.3-0.3-0.3-0.0-0.00.3-0.10.0-0.50.80.90.9-0.70.70.3-0.7
Pavlov. Cond. lever contacts0.40.51.1-0.8-1.0-0.4-0.9-0.91.00.6-0.80.20.80.20.5-0.90.4-0.6-0.8
Pavlov. Cond. magazine entry number0.60.81.80.90.81.10.40.4-0.8-0.60.40.2-1.1-1.2-1.11.0-1.3-0.61.0
Pavlov. Cond. intertrial magazine entries0.50.65.00.5-0.00.80.30.3-0.0-0.30.3-1.00.90.80.7-0.40.5-2.2-0.7
Pavlov. Cond. lever-magazine prob. diff.0.30.41.1-0.3-0.3-0.20.00.00.4-0.10.0-0.61.01.11.1-0.80.70.3-0.8
Pavlov. Cond. response bias0.20.30.8-0.7-0.8-0.4-0.7-0.70.90.5-0.60.30.60.20.4-0.80.2-0.2-0.6
Time in closed arm before self-admin0.10.20.9-0.2-0.1-0.2-0.4-0.20.20.6-0.40.5-0.3-0.5-0.3-0.4-0.20.90.4
Time in closed arm after self-admin0.30.31.4-0.1-0.1-0.2-0.4-0.20.0-0.0-0.30.5-0.5-0.6-0.61.2-0.2-1.10.5
Time in open arm before self-admin1.01.02.3-1.1-1.3-1.1-0.9-1.11.20.9-1.10.30.90.60.7-0.31.1-1.5-1.2
Time in open arm after self-admin0.10.11.5-0.00.10.00.10.0-0.00.40.10.1-0.1-0.1-0.0-0.6-0.31.2-0.1
Bone: periosteal estimation0.40.98.60.4-0.0-0.20.40.4-0.3-0.30.6-0.70.50.90.20.51.4-2.9-0.7
Bone: periosteal perimeter0.20.41.30.70.40.80.30.3-0.5-0.40.4-0.0-0.7-0.6-0.80.6-0.6-1.10.7
Bone: post-yield work0.91.22.41.21.50.71.41.4-1.5-1.51.5-0.9-0.60.2-0.10.8-0.51.30.6
Progressive ratio test 1 active lever presses1.21.23.11.20.91.21.21.2-0.9-1.41.4-1.80.91.51.1-0.50.40.3-0.6
Progressive ratio test 1 breakpoint1.41.53.71.20.91.31.31.3-0.9-1.51.5-1.91.01.71.2-0.50.50.2-0.8
Progressive ratio test 1 inactive lever presses1.01.12.21.00.91.21.21.2-0.8-1.41.1-1.50.51.30.8-0.8-0.11.3-0.1
Progressive ratio test 2 active lever presses1.31.43.70.70.61.01.01.0-0.4-1.01.0-1.91.51.91.8-1.10.60.9-1.0
Progressive ratio test 2 breakpoint1.41.64.70.30.20.70.70.7-0.0-0.70.8-1.91.92.22.2-1.50.90.5-1.4
Progressive ratio test 2 inactive lever presses0.80.92.40.70.70.90.90.9-0.5-0.80.9-1.30.81.31.1-1.0-0.01.6-0.3
Incentive Sensitization - Responses1.11.13.9-0.2-0.30.10.20.20.50.10.1-1.31.91.72.0-1.31.10.0-1.5
Incentive Sensitization - Breakpoint1.11.14.1-0.1-0.10.30.30.30.3-0.10.3-1.41.81.82.0-1.31.00.2-1.4
Sum of active levers in priming session hrs 5-61.61.63.41.51.41.61.51.6-1.3-1.41.5-1.80.51.40.9-0.1-0.10.5-0.6
Progressive ratio0.10.10.40.50.30.60.30.3-0.3-0.40.4-0.40.00.1-0.0-0.1-0.2-0.10.1
Food seeking constrained by brief footshock0.20.20.8-0.2-0.2-0.4-0.5-0.50.1-0.1-0.40.8-0.7-0.8-0.90.0-0.3-0.30.5
Seeking ratio, punishment vs. effort0.40.41.0-0.9-0.7-1.0-0.8-0.80.70.8-0.90.9-0.2-0.6-0.4-0.20.1-0.00.0
Retroperitoneal fat weight0.31.13.60.70.40.41.01.0-0.5-0.80.8-1.61.01.91.10.41.4-1.5-0.9
Reaction time number correct2.33.37.32.11.92.52.12.2-1.6-2.42.2-2.70.91.91.50.0-0.51.0-0.4
Reaction time mean minus median0.40.51.40.20.5-0.20.20.2-0.5-0.20.20.6-1.0-0.9-0.81.0-0.91.20.8
Reaction time mean minus median AUC0.20.20.9-0.4-0.1-0.5-0.3-0.30.20.4-0.30.6-0.4-0.6-0.30.2-0.40.90.3
Reaction time num false alarms0.10.10.30.0-0.30.5-0.3-0.30.4-0.1-0.2-0.00.4-0.20.1-0.6-0.4-0.4-0.3
Reaction time num false alarms AUC0.10.10.50.0-0.20.5-0.2-0.10.3-0.20.0-0.30.60.00.4-0.7-0.2-0.5-0.5
Reaction time trials correct on left2.33.37.32.11.92.52.12.2-1.6-2.42.2-2.70.91.91.50.0-0.51.0-0.4
Reaction time trials on left2.33.37.12.12.02.52.22.2-1.7-2.52.3-2.70.81.81.40.2-0.61.1-0.3
Reaction time mean1.82.64.31.82.01.61.51.6-1.8-1.61.6-0.4-1.6-1.0-1.21.5-2.11.91.6
Reaction time mean AUC1.82.55.01.71.81.61.31.4-1.7-1.51.4-0.1-1.7-1.3-1.31.5-2.22.01.7
Median of all reaction times1.82.54.51.81.91.81.51.6-1.7-1.61.5-0.5-1.5-1.0-1.11.2-2.12.01.6
Reaction time omissions2.23.07.81.21.50.80.80.8-1.5-0.60.71.1-2.8-2.3-2.62.8-2.30.42.3
Reaction time false alarm rate0.60.91.8-1.0-1.2-0.7-1.3-1.31.21.1-1.21.10.1-0.9-0.4-0.8-0.0-0.9-0.3
Reaction time premature initiation rate0.91.23.0-1.0-0.8-1.0-1.3-1.30.81.0-1.21.7-1.1-1.6-1.30.2-0.90.10.9
Reaction time premature initiations0.10.21.10.30.40.50.10.1-0.2-0.50.20.0-0.5-0.4-0.30.2-1.10.70.6
Std. dev. reaction times0.40.61.70.40.70.10.40.4-0.7-0.40.40.4-1.1-0.8-0.81.0-0.91.30.9
Reaction time trials completed2.33.37.12.12.02.52.22.2-1.7-2.52.3-2.70.81.81.40.2-0.61.1-0.3
Reaction time trials AUC2.23.26.72.11.92.52.12.2-1.7-2.42.2-2.60.71.71.30.2-0.61.0-0.2
Run reversals in cocaine runway, females0.40.41.3-0.4-0.4-0.20.10.10.50.2-0.4-0.41.00.71.0-1.20.50.0-0.8
Run reversals in cocaine runway, males0.40.41.10.50.30.60.60.6-0.3-0.50.6-1.10.71.00.8-0.60.4-0.2-0.3
Latency to leave start box in cocaine runway0.30.30.80.40.50.20.40.4-0.5-0.70.30.3-0.8-0.6-0.70.9-0.70.40.7
Latency to leave start box in cocaine runway, F0.40.41.20.40.60.20.50.5-0.6-0.90.30.3-0.9-0.7-0.81.1-0.70.40.8
Latency to leave start box in cocaine runway, M0.10.10.3-0.00.1-0.2-0.1-0.1-0.10.2-0.10.4-0.5-0.4-0.50.4-0.30.20.4
Std. dev. time between licks in bursts0.50.61.50.70.70.40.40.4-0.8-0.30.60.4-1.2-0.8-1.21.2-0.8-0.31.0
Total sessions with >9 infusions1.21.33.21.51.41.31.31.3-1.5-1.81.4-0.6-0.9-0.2-0.71.3-0.90.40.8
Short access day 1 total inactive lever presses2.32.55.9-1.2-1.4-0.8-0.8-0.81.51.1-0.8-0.92.42.22.3-2.22.0-1.0-2.0
Short access day 10 total inactive lever presses1.21.32.4-1.6-1.5-1.6-1.6-1.61.51.3-1.20.80.6-0.00.4-1.10.9-0.7-0.6
Short access day 1 total infusions0.50.61.80.70.50.70.80.8-0.5-0.70.9-1.30.71.30.90.00.5-0.1-0.5
Short access day 10 total infusions1.31.53.21.51.41.51.51.5-1.3-1.81.5-1.40.00.90.40.1-0.51.40.2
Short access total infusions1.61.83.21.71.61.81.81.8-1.6-1.71.8-1.60.01.00.40.7-0.51.00.2
Short access day 1 locomotion1.11.22.6-0.9-1.1-0.8-0.8-0.81.10.4-0.5-0.51.61.41.5-1.31.4-0.8-1.4
Short access day 10 total locomotion0.40.51.2-0.8-0.9-0.6-0.7-0.70.90.5-0.80.10.70.20.6-1.10.70.2-0.5
Short access total locomotion0.50.51.40.70.60.90.90.9-0.5-0.90.7-1.20.51.10.8-0.20.10.6-0.2
One hour access (0.3 mA shock)0.70.82.00.70.70.91.01.0-0.6-1.21.0-1.40.91.01.2-0.40.20.9-0.7
Compulsive drug intake0.20.20.50.60.40.60.60.6-0.5-0.40.5-0.60.20.40.20.40.2-0.7-0.2
One hour access (shock baseline)0.91.12.31.01.11.21.21.2-1.0-1.41.3-1.30.30.90.80.1-0.41.5-0.1
Social response proportion2.22.44.01.82.01.41.61.7-2.0-1.71.7-0.5-1.6-0.7-1.11.9-1.41.01.6
Social responses0.10.10.2-0.3-0.4-0.2-0.5-0.40.40.4-0.3-0.00.30.10.3-0.50.20.1-0.1
Social time4.56.010.52.62.82.22.02.0-2.7-2.32.10.1-3.1-2.2-2.72.8-3.21.33.0
Soleus weight6.619.436.0-5.8-5.8-5.5-6.0-6.05.55.5-5.84.61.1-1.3-0.3-2.72.6-2.1-1.5
Bone: stiffness0.10.20.70.50.30.30.20.2-0.4-0.40.30.1-0.6-0.4-0.70.7-0.3-0.80.5
Tibialis anterior weight1.55.312.9-1.5-2.1-1.0-1.0-1.02.00.6-0.8-1.43.63.13.1-2.63.3-2.9-3.1
Time to tail flick, vehicle, before self-admin1.61.65.21.21.30.90.80.9-1.4-1.20.80.3-1.6-1.0-1.52.3-1.40.81.7
Time to tail flick, vehicle, after self-admin1.51.73.31.41.71.41.31.4-1.5-1.81.3-0.6-1.0-0.4-0.60.9-1.51.81.0
Time to tail flick, test, before self-admin1.91.84.4-1.3-1.1-1.5-1.5-1.51.02.1-1.42.1-1.1-1.9-1.40.7-0.4-0.40.6
Time to tail flick, test, after self-admin2.12.24.5-1.8-1.5-1.9-2.1-1.91.51.6-2.02.1-0.6-1.7-0.9-0.9-0.10.60.1
Delta time to tail flick, vehicle, before/after SA0.90.92.91.01.21.01.01.0-1.1-1.01.0-0.4-0.7-0.3-0.4-0.0-1.11.70.9
Delta time to tail flick, test, before/after SA0.90.82.5-1.2-1.0-1.1-1.1-1.11.10.5-1.20.80.4-0.30.3-1.60.30.9-0.3
Tibia length2.26.111.83.43.22.63.43.4-3.4-3.03.2-2.3-1.00.7-0.42.5-0.6-0.50.7
Ambulatory time before self-admin1.31.42.5-1.4-1.5-1.5-1.4-1.41.41.6-1.51.10.4-0.50.0-0.60.9-1.5-0.7
Ambulatory time after self-admin0.60.61.8-0.7-0.8-0.6-0.7-0.60.81.0-0.70.00.90.40.7-1.30.8-0.7-1.0
Bone: tissue strength2.52.48.21.00.70.80.20.2-0.9-0.40.21.3-2.6-2.3-2.92.1-1.9-0.52.3
Total heroin consumption4.45.18.7-2.8-3.0-2.6-2.6-2.62.92.3-2.61.02.00.81.5-2.42.2-1.2-2.1
Bone: trabecular number4.36.712.7-3.4-3.5-2.7-3.3-3.33.63.1-3.21.71.90.21.2-3.01.7-0.5-1.7
Bone: trabecular spacing2.53.26.62.32.41.52.22.2-2.6-2.12.2-0.9-1.4-0.3-1.12.6-0.9-0.11.0
Bone: trabecular thickness0.50.62.9-1.0-0.7-1.7-0.8-0.80.50.9-0.70.9-0.1-0.1-0.1-0.01.10.2-0.3
Bone: trabecular tissue density1.62.35.51.21.50.70.90.9-1.5-0.80.90.8-2.3-1.7-2.02.3-1.91.21.9
Water consumed over 24 hours0.50.62.6-0.3-0.3-0.80.00.00.1-0.60.0-0.40.91.10.8-0.11.6-1.2-1.2
Number of responses in last shaping day1.21.22.4-1.1-1.2-1.0-1.0-1.01.20.5-0.6-0.31.51.21.5-1.31.3-0.4-1.4