Hub : Genes

Pbx2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Pbx2 0.7 0.14 3.8e-06 0.16 0.15 0.16 0.24 1.7e-03 2.7e-03 1.7e-03 1.4e-04
2 BLA gene expression Pbx2 0.34 0.1 0.0e+00 0.28 0.32 0.34 0.34 7.1e-15 2.9e-17 1.7e-18 1.9e-18
3 IL gene expression Pbx2 0.47 0.15 4.5e-08 0.18 0.22 0.26 0.22 4.3e-05 4.0e-06 5.5e-07 5.8e-06
4 pVTA gene expression Pbx2 0.3 0.11 1.3e-14 0.13 0.17 0.17 0.16 1.1e-10 1.2e-13 1.8e-13 3.0e-13
5 PL mRNA stability Pbx2 0.03 0.02 3.3e-03 0.03 0.02 0.02 0.03 3.5e-04 1.8e-03 1.4e-03 5.2e-04
6 LHb gene expression Pbx2 0.27 0.12 4.3e-05 0.11 0.09 0.07 0.1 1.2e-03 3.1e-03 8.5e-03 2.7e-03
7 Adipose gene expression Pbx2 0.15 0.07 1.8e-08 0.04 0.06 0.05 0.04 4.2e-05 1.5e-07 6.6e-06 1.4e-05
8 PL gene expression Pbx2 0.37 0.11 0.0e+00 0.37 0.36 0.41 0.41 1.2e-42 1.6e-41 1.3e-48 9.8e-49
9 OFC gene expression Pbx2 0.42 0.16 9.4e-07 0.18 0.18 0.2 0.24 3.6e-05 4.3e-05 1.5e-05 1.7e-06
10 Brain gene expression Pbx2 0.23 0.09 0.0e+00 0.16 0.19 0.18 0.19 7.6e-15 2.4e-17 6.9e-17 4.3e-17
11 NAcc gene expression Pbx2 0.25 0.1 0.0e+00 0.23 0.24 0.25 0.25 7.4e-34 5.6e-36 2.0e-37 3.6e-37
12 IC gene expression Pbx2 0.37 0.12 4.9e-13 0.18 0.28 0.26 0.26 4.2e-08 5.6e-12 4.2e-11 2.9e-11
13 Liver gene expression Pbx2 0.08 0.04 6.7e-08 0.05 0.06 0.06 0.06 5.7e-06 1.4e-07 9.2e-08 1.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.11.95.01.01.51.12.2-0.42.01.91.41.11.10.31.11.3
Area under the delay curve0.10.20.80.2-0.3-0.1-0.90.2-0.4-0.50.20.0-0.10.8-0.1-0.2
BMI with tail1.96.611.4-2.3-2.6-2.7-1.8-3.4-1.50.3-2.6-2.9-3.0-3.1-2.9-2.9
BMI without tail2.47.511.5-3.4-2.8-3.2-2.5-2.5-3.0-0.0-2.7-2.8-2.8-2.8-2.7-2.8
Body weight3.816.821.8-3.9-4.7-4.2-4.3-3.5-3.9-2.0-4.6-4.6-4.3-4.1-4.3-4.0
Weight adjusted by age2.03.07.9-1.7-2.0-1.8-1.7-0.7-2.8-1.3-1.8-1.6-1.6-1.5-1.7-1.3
Bone surface0.00.10.2-0.0-0.20.10.1-0.40.1-0.5-0.3-0.20.1-0.50.00.4
Bone volume0.10.20.7-0.20.10.00.6-0.80.40.6-0.0-0.10.1-0.60.10.4
Breakpoint value in progressive ratio session0.20.30.50.70.60.60.30.40.5-0.20.50.50.50.60.50.3
Number of licking bursts0.40.72.61.00.41.0-0.21.00.6-1.60.10.30.70.80.61.2
Context. condit. distance diff. score3.94.89.13.02.12.72.12.22.1-1.21.82.02.31.72.12.4
Locomotion velocity, session 12.02.13.51.31.51.51.31.90.6-0.11.51.51.71.61.71.7
Locomotion distance, session 11.21.62.81.41.41.21.70.51.71.11.41.21.10.91.11.0
Locomotion velocity, session 20.70.81.81.30.71.00.41.10.8-0.40.90.90.81.20.80.7
Locomotion distance, session 21.11.54.52.11.11.41.20.71.90.21.31.00.91.10.80.7
Locomotion velocity, session 30.10.10.8-0.30.2-0.30.00.1-0.20.90.20.10.00.10.1-0.1
Locomotion distance, session 32.32.53.61.71.91.61.81.41.81.01.81.61.51.51.51.3
Stereotopy head waving bouts, day 31.01.13.2-0.6-1.3-0.7-1.7-0.2-1.2-1.8-1.3-1.0-0.8-0.5-0.8-0.5
Stereotopy head waving duration, day 30.91.13.3-1.2-1.2-1.0-1.5-0.0-1.8-1.2-1.1-0.8-0.7-0.5-0.7-0.3
Locomotion velocity, session 74.44.89.73.12.42.42.61.33.00.92.52.01.82.01.71.6
Locomotion distance, session 76.07.610.83.13.22.93.31.93.21.53.12.72.72.52.72.4
Stereotopy head waving bouts, day 70.20.20.8-0.50.2-0.0-0.60.9-0.6-0.00.20.40.40.70.50.4
Stereotopy head waving duration, day 70.20.30.9-0.8-0.4-0.5-1.00.3-0.9-0.2-0.4-0.2-0.20.1-0.2-0.2
Locomotion velocity, session 81.82.26.12.00.71.8-0.02.30.7-2.50.61.01.31.51.11.4
Locomotion distance, session 83.75.413.83.72.23.02.31.92.9-1.02.01.92.21.82.02.3
Degree of sensitization distance0.20.21.20.70.10.5-0.10.30.2-1.10.00.10.30.30.30.5
Degree of sensitization stereotypy0.60.61.30.10.90.50.31.20.20.50.91.00.91.11.00.8
Conditioned locomotion1.21.42.1-0.7-1.4-0.9-1.2-1.1-0.8-1.2-1.4-1.4-1.2-1.2-1.3-1.0
Cocaine response after cond. corrected0.30.41.20.9-0.30.30.0-0.91.1-0.7-0.4-0.6-0.3-0.5-0.4-0.0
Cocaine response after cond. not corrected0.60.72.80.2-1.0-0.2-1.2-0.5-0.1-1.7-1.1-1.0-0.7-0.7-0.8-0.5
Cocaine response before conditioning2.12.57.1-1.9-1.6-1.5-2.50.3-2.7-1.5-1.5-1.1-1.1-0.7-1.0-1.4
Saline control response3.44.510.6-3.3-1.8-2.7-1.6-2.2-2.41.4-1.9-1.9-2.0-1.9-1.8-2.0
Bone: connectivity density0.60.92.90.90.90.91.7-0.61.61.00.80.70.6-0.10.60.9
Bone: cortical apparent density1.52.14.6-1.4-1.4-1.6-1.0-2.1-0.61.0-1.2-1.6-1.6-1.7-1.5-1.5
Bone: cortical area0.20.30.8-0.1-0.6-0.3-0.9-0.5-0.2-0.7-0.6-0.6-0.5-0.3-0.4-0.7
Bone: cortical porosity1.21.33.30.21.10.60.31.7-0.50.41.31.21.31.81.41.3
Bone: cortical porosity1.21.33.40.41.00.80.21.8-0.5-0.21.11.21.31.81.41.5
Bone: cortical thickness0.50.82.7-0.8-0.5-0.9-0.5-1.70.11.3-0.4-0.9-0.9-0.7-0.8-1.2
Bone: cortical thickness1.51.74.0-1.2-1.0-1.4-0.9-2.0-0.21.3-1.0-1.4-1.5-1.2-1.4-1.8
Bone: cortical tissue density1.42.04.1-1.4-1.3-1.6-1.0-2.0-0.60.9-1.2-1.5-1.6-1.6-1.5-1.4
Condit. Reinf. active minus inactive responses1.61.83.71.41.51.21.01.50.90.71.71.51.31.91.41.0
Condit. Reinf. active-inactive response ratio0.10.10.4-0.10.1-0.2-0.20.1-0.20.70.40.2-0.10.50.0-0.3
Condit. Reinf. active responses1.51.83.01.71.61.21.31.21.41.01.71.41.21.71.20.7
Condit. Reinf. inactive responses1.72.14.31.61.71.32.00.52.11.61.71.31.11.11.20.6
Incentive salience index mean2.73.37.22.71.82.11.31.91.8-0.31.91.81.72.21.71.3
Condit. Reinf. lever presses2.63.610.53.21.72.51.61.52.4-1.21.61.61.71.71.61.5
Condit. Reinf. active minus inactive responses0.40.51.8-1.0-0.6-0.7-0.90.2-1.3-0.5-0.7-0.5-0.4-0.3-0.4-0.5
Condit. Reinf. active-inactive response ratio0.60.72.8-0.9-0.8-0.7-1.10.3-1.7-1.2-0.9-0.5-0.4-0.4-0.4-0.4
Condit. Reinf. active responses0.10.10.5-0.6-0.0-0.3-0.20.3-0.70.2-0.3-0.1-0.0-0.20.0-0.1
Condit. Reinf. inactive responses0.10.10.8-0.3-0.0-0.30.1-0.40.20.9-0.1-0.2-0.3-0.3-0.2-0.3
Condit. Reinf. lever presses0.71.01.60.31.20.71.21.10.20.91.01.11.10.91.21.1
Condit. Reinf. lever reinforcers received0.10.10.5-0.40.2-0.1-0.00.7-0.50.1-0.00.20.30.20.30.1
Conditioned reinforcement - actives0.00.10.5-0.30.2-0.10.5-0.1-0.20.70.20.10.0-0.10.10.1
Conditioned reinforcement - inactives0.10.10.3-0.30.3-0.20.50.1-0.50.60.30.20.10.40.10.0
Conditioned locomotion0.10.10.30.10.30.10.50.4-0.30.10.30.40.30.20.20.2
Patch foraging indifference point 0 sec1.42.55.6-2.4-1.6-2.0-1.4-1.6-1.70.9-1.2-1.5-1.7-1.4-1.6-1.4
Patch foraging indifference point AUC0.10.10.5-0.1-0.1-0.1-0.70.4-0.3-0.4-0.20.00.10.40.1-0.1
Delay disc. indifference point, 0s delay0.20.21.00.6-0.20.4-0.30.40.1-1.00.10.00.10.60.00.6
Delay disc. indifference point, 16s delay0.10.10.5-0.00.1-0.3-0.1-0.3-0.10.70.40.2-0.10.5-0.0-0.4
Delay disc. indifference point, 2s delay0.40.41.70.1-0.30.0-0.90.9-1.0-1.3-0.00.20.10.80.00.2
Delay disc. indifference point, 24s delay0.20.21.0-0.4-0.2-0.4-0.70.4-1.00.10.20.0-0.10.8-0.0-0.2
Delay disc. indifference point, 4s delay0.80.82.6-0.8-1.1-0.8-1.6-0.2-1.3-0.9-0.8-0.8-0.8-0.0-0.7-0.9
Delay disc. indifference point, 8s delay0.20.21.20.50.10.3-0.40.30.2-0.20.60.40.21.10.2-0.0
Indifference point function ln k0.40.71.41.10.60.90.21.20.5-0.70.80.80.81.20.70.5
Indifference point function log k0.40.71.41.10.60.90.21.20.5-0.70.80.80.81.20.70.5
Patch foraging total patch changes 0 sec1.42.65.7-2.4-1.5-2.0-1.4-1.6-1.71.0-1.1-1.5-1.7-1.3-1.6-1.5
Patch foraging total patch changes 12 sec1.21.63.8-1.9-1.2-1.6-1.2-1.3-1.30.8-1.0-1.1-1.2-1.1-1.1-1.3
Patch foraging total patch changes 18 sec1.42.25.3-1.7-1.2-1.7-0.6-2.3-0.41.8-0.9-1.4-1.6-1.7-1.5-1.2
Patch foraging total patch changes 24 sec0.30.64.8-0.60.3-0.40.7-0.90.52.20.60.2-0.2-0.2-0.1-0.1
Patch foraging total patch changes 6 sec1.21.84.5-2.1-1.2-1.7-1.0-1.6-1.31.2-0.9-1.0-1.4-1.1-1.3-1.2
Patch foraging time to switch 0 sec0.71.43.5-0.7-1.1-1.1-0.2-1.9-0.10.5-0.9-1.2-1.4-1.8-1.5-1.2
Patch foraging water rate 0 sec0.10.30.6-0.5-0.7-0.5-0.8-0.4-0.5-0.4-0.6-0.6-0.6-0.1-0.6-0.4
Patch foraging water rate 12 sec0.10.21.1-0.10.30.00.4-0.60.71.10.20.10.10.10.10.5
Patch foraging water rate 18 sec0.20.30.7-0.8-0.7-0.7-0.6-0.7-0.40.2-0.5-0.5-0.7-0.3-0.7-0.4
Patch foraging water rate 24 sec0.20.20.6-0.8-0.4-0.5-0.2-0.8-0.10.5-0.4-0.5-0.4-0.5-0.4-0.3
Patch foraging water rate 6 sec0.10.10.5-0.2-0.3-0.4-0.3-0.70.20.4-0.3-0.3-0.5-0.1-0.4-0.4
Seeking ratio, delayed vs. immediate footshock0.91.23.1-1.5-1.1-1.1-1.7-0.4-0.9-0.2-1.0-0.8-0.9-0.8-0.8-1.6
Distance traveled before self-admin0.60.82.2-0.1-1.0-0.5-0.7-1.1-0.1-0.9-1.0-1.2-0.9-1.5-1.0-0.7
Distance traveled after self-admin1.92.43.6-1.6-1.8-1.4-1.9-1.1-1.5-1.1-1.9-1.7-1.4-1.6-1.4-1.5
Extensor digitorum longus weight0.00.21.50.1-0.30.0-0.20.1-0.5-1.2-0.5-0.2-0.1-0.4-0.20.0
Bone: elastic displacement0.30.41.4-0.00.60.20.60.40.11.20.80.60.50.70.50.7
Bone: elastic work0.10.10.2-0.3-0.2-0.4-0.4-0.3-0.40.1-0.1-0.3-0.30.1-0.3-0.1
Bone: endosteal estimation2.04.413.7-1.6-2.3-1.4-2.80.3-3.0-3.7-2.6-1.8-1.4-1.4-1.6-1.1
Bone: endosteal perimeter0.61.310.50.3-1.00.2-1.40.8-0.9-3.2-1.2-0.6-0.2-0.2-0.4-0.1
Epididymis fat weight3.612.332.7-3.6-2.5-4.0-0.8-5.7-1.23.9-2.0-3.3-3.9-3.9-3.6-4.0
Delta time in closed arm before/after self-admin0.70.61.0-0.8-1.0-0.7-0.6-0.8-0.9-0.7-1.0-0.9-0.8-0.9-0.9-0.1
Delta time in open arm before/after self-admin0.10.10.8-0.20.3-0.10.40.2-0.20.90.40.40.10.00.20.0
Diff in mean of infusions in LGA sessions1.41.75.91.91.21.61.30.72.40.11.21.11.10.91.10.5
Delay discount exponential model param0.20.20.8-0.10.20.10.9-0.30.50.5-0.3-0.10.1-0.90.10.2
Extinction: sum of active levers before priming0.40.41.31.10.40.80.10.90.4-1.00.40.50.50.60.40.4
Active lever presses in extinction session 60.40.41.00.50.80.21.0-0.00.10.90.90.60.30.70.30.4
Bone: final force2.84.46.1-1.9-2.2-2.1-2.0-2.4-1.3-0.3-2.3-2.5-2.4-2.2-2.3-2.4
Bone: final moment2.03.34.5-1.8-1.9-1.9-1.6-2.1-1.3-0.2-2.0-2.1-2.0-1.9-2.0-1.9
Food consumed during 24 hour testing period1.01.32.5-0.3-1.4-0.8-1.3-1.0-0.6-1.6-1.4-1.3-1.2-1.1-1.3-1.1
Glucose1.82.98.81.90.91.90.22.60.2-3.00.71.31.61.61.42.1
Heart weight1.11.76.3-1.6-1.4-1.3-1.70.1-2.5-1.0-1.3-0.9-1.0-0.5-1.0-1.0
Delay discount hyperbolic model param0.20.20.9-0.00.20.10.9-0.40.60.6-0.2-0.10.1-1.00.00.2
Intermittent access intake day 1-15 change0.00.10.3-0.5-0.3-0.2-0.5-0.00.3-0.1-0.4-0.2-0.1-0.3-0.10.0
Intermittent access intake escalation0.10.20.9-1.0-0.3-0.5-0.5-0.40.10.7-0.2-0.2-0.2-0.2-0.1-0.3
Intermittent access intake escalation 20.10.10.2-0.20.10.2-0.20.50.3-0.20.10.20.30.30.40.4
Intermitt. access day 1 inactive lever presses0.10.53.90.1-0.70.2-0.60.4-0.3-2.0-0.9-0.6-0.1-0.3-0.20.5
Intermitt. access day 15 inactive lever presses0.20.41.1-0.6-0.7-0.6-0.6-0.3-1.0-0.5-0.8-0.7-0.6-0.6-0.6-0.6
Intermitt. access escalation Index0.91.34.22.01.01.50.80.51.9-0.60.80.90.90.80.90.6
Intermittent access day 1 total infusions1.82.85.41.32.01.42.31.41.01.21.92.01.71.71.71.9
Intermittent access day 15 total infusions0.50.71.9-0.01.00.41.10.50.61.41.01.00.80.80.80.8
Intermittent access terminal intake (last 3 days)0.40.51.4-0.30.80.20.90.6-0.11.20.80.90.70.70.70.7
Intermittent access total infusions0.81.01.90.11.20.51.40.80.11.31.11.20.91.01.01.1
Intermittent access day 1 locomotion0.20.21.00.10.50.21.0-0.10.31.00.60.50.30.00.30.3
Intermittent access day 15 total locomotion0.50.91.3-1.1-1.0-1.0-0.9-0.9-0.6-0.0-1.0-1.0-0.9-1.0-0.9-1.1
Intermittent access total locomotion0.10.20.7-0.8-0.1-0.60.1-0.4-0.40.8-0.1-0.2-0.3-0.3-0.2-0.3
Intermittent access standard deviation1.32.76.2-2.5-1.7-2.0-1.3-1.6-1.80.4-1.7-1.7-1.7-1.6-1.6-1.2
Left kidney weight3.014.016.8-4.0-4.1-4.1-3.8-3.5-3.9-0.8-3.9-4.0-3.9-3.8-3.9-3.8
Right kidney weight3.214.518.2-3.9-4.2-4.0-3.7-3.8-3.7-1.1-4.2-4.3-4.0-4.0-4.0-3.6
Cocaine induced anxiety0.10.20.90.7-0.30.2-0.3-0.20.3-0.9-0.4-0.5-0.2-0.2-0.2-0.3
Post-drug Anxiety0.40.40.6-0.4-0.7-0.4-0.7-0.4-0.5-0.8-0.7-0.8-0.6-0.6-0.6-0.8
Baseline Anxiety0.20.20.8-0.9-0.5-0.4-0.5-0.2-0.6-0.0-0.3-0.3-0.3-0.2-0.3-0.2
Tail length1.55.714.5-2.5-2.7-2.0-3.50.2-3.8-3.1-2.7-2.0-1.6-1.2-1.6-1.5
Length with tail2.39.818.5-2.8-3.7-2.7-4.3-0.8-4.2-3.7-3.7-3.1-2.7-2.2-2.8-2.3
Length without tail3.511.316.3-2.3-4.0-2.9-3.7-2.6-3.1-3.2-4.0-4.0-3.5-3.3-3.7-2.8
Times rat made contact with spout1.01.24.10.41.20.40.90.41.22.01.51.20.81.20.90.6
Lifetime Intake0.60.71.40.11.00.41.20.6-0.01.11.01.10.80.90.81.1
Liver weight, left1.32.27.5-0.7-1.8-0.8-2.0-0.2-1.4-2.7-1.8-1.5-1.1-1.3-1.2-0.8
Liver weight, right0.81.58.8-0.0-1.2-0.3-1.70.7-1.4-3.0-1.3-0.8-0.6-0.3-0.7-0.4
Locomotor activity0.71.13.0-1.1-1.1-0.9-1.70.3-1.6-1.3-1.1-0.9-0.7-0.4-0.6-0.8
Locomotor testing distance0.40.71.7-0.7-0.9-0.6-1.30.3-1.1-1.2-0.8-0.7-0.6-0.5-0.6-0.7
Locomotor testing rearing0.81.62.4-1.3-1.5-1.2-1.4-0.6-1.4-1.3-1.5-1.2-1.2-1.3-1.2-0.9
Locomotion in novel chamber0.10.10.4-0.6-0.2-0.4-0.3-0.3-0.10.1-0.3-0.3-0.3-0.3-0.3-0.2
Locomotion in novel chamber post-restriction1.21.92.8-1.4-1.5-1.6-1.2-1.4-1.4-0.1-1.3-1.5-1.5-1.5-1.5-1.7
Fecal boli incidents, locomotor time 10.20.31.70.20.50.21.3-0.1-0.10.60.40.30.3-0.20.20.7
Change in fecal boli incidents, locomotor task1.11.04.1-0.3-1.3-0.3-1.80.1-0.7-2.0-1.2-0.8-0.7-0.3-0.7-0.7
Time >=10cm from walls, locomotor time 13.73.96.0-1.0-2.4-1.5-2.3-1.6-1.6-2.3-2.2-2.2-2.1-2.2-2.2-1.7
Bouts of movement, locomotor time 10.40.41.41.00.70.80.30.41.20.10.70.40.70.60.70.4
Total resting periods, locomotor time 10.30.40.90.90.60.70.30.41.0-0.10.60.30.60.50.70.4
Rest time, locomotor task time 10.10.20.4-0.10.30.20.30.7-0.5-0.40.10.30.40.30.40.7
Distance moved, locomotor task time 10.40.61.2-0.3-0.8-0.7-1.1-0.8-0.4-0.2-0.7-0.8-0.9-0.6-0.9-1.1
Vertical activity count, locomotor time 10.61.52.6-0.9-1.3-1.2-1.5-1.5-0.40.1-1.1-1.3-1.5-1.0-1.4-1.6
Time >=10cm from walls, locomotor time 21.52.24.4-0.9-1.9-1.1-2.1-0.7-1.7-1.9-1.6-1.4-1.4-1.1-1.5-1.1
Bouts of movement, locomotor time 20.10.10.3-0.20.00.0-0.50.5-0.2-0.20.10.20.30.50.30.2
Total resting periods, locomotor time 20.20.31.20.00.30.4-0.31.1-0.2-0.50.30.50.70.90.70.6
Rest time, locomotor task time 20.30.42.70.7-0.20.6-0.10.40.4-1.6-0.4-0.20.2-0.10.10.8
Distance moved, locomotor task time 20.70.91.7-0.7-0.8-1.1-0.6-1.3-0.70.7-0.6-0.8-1.1-0.8-1.1-1.3
Vertical activity count, locomotor time 20.60.91.6-0.8-1.0-1.0-0.9-1.2-0.90.3-0.6-0.9-1.1-0.7-1.1-1.3
Light reinforcement 10.82.03.4-0.8-1.7-1.1-1.4-1.8-0.1-0.6-1.7-1.8-1.7-1.8-1.7-1.2
Light reinforcement 20.71.01.6-0.3-1.3-0.7-1.0-1.0-0.1-1.1-1.2-1.1-1.2-1.2-1.3-0.9
Bone: marrow area2.35.013.6-1.7-2.5-1.6-2.90.1-3.1-3.7-2.8-1.9-1.6-1.6-1.7-1.2
Bone: maximum diameter0.40.85.01.10.00.9-0.51.20.1-2.2-0.10.30.50.70.40.5
Bone: maximum force1.42.53.5-1.4-1.7-1.6-1.5-1.8-1.2-0.4-1.7-1.9-1.7-1.7-1.7-1.6
Bone: maximum moment0.91.72.4-1.3-1.4-1.3-1.1-1.5-1.2-0.4-1.4-1.5-1.4-1.4-1.4-1.1
Mean time between licks in bursts0.61.53.41.40.91.50.51.80.4-1.70.60.81.41.01.31.4
Mean num. licks in bursts0.50.76.0-0.80.2-0.80.5-0.8-0.12.50.50.3-0.3-0.2-0.2-0.8
Cd content in liver0.30.31.2-0.0-0.1-0.20.9-1.10.50.8-0.1-0.3-0.4-0.7-0.5-0.1
Co content in liver1.82.03.1-1.4-1.5-1.6-0.9-1.7-1.20.3-1.3-1.5-1.6-1.5-1.6-1.8
Cu content in liver1.11.34.01.01.40.71.00.31.72.01.30.90.71.10.80.3
Fe content in liver0.70.91.8-1.1-0.8-1.2-0.2-1.4-0.80.8-0.8-0.9-1.0-1.2-1.0-0.8
K content in liver0.70.71.41.00.91.00.90.51.20.20.70.80.80.50.80.9
Mg content in liver1.51.63.41.91.01.60.51.51.4-1.40.71.01.21.01.11.3
Mn content in liver1.11.25.81.90.21.2-0.21.40.6-2.40.20.40.50.80.41.0
Na content in liver0.10.10.40.30.40.1-0.10.10.70.60.30.20.30.40.4-0.1
Rb content in liver0.10.10.60.30.20.40.7-0.20.8-0.10.10.20.2-0.30.10.4
Se content in liver2.42.88.62.01.31.8-0.02.91.0-1.91.21.61.62.11.51.2
Sr content in liver0.20.20.8-0.7-0.5-0.4-0.1-0.2-0.9-0.6-0.5-0.4-0.3-0.3-0.40.2
Zn content in liver0.10.10.40.30.20.30.20.5-0.0-0.6-0.00.30.10.10.10.4
Bone: minimum diameter0.61.17.30.3-1.0-0.0-1.40.3-0.8-2.7-1.1-0.8-0.5-0.4-0.6-0.5
Time in familiar zone, hab. session 12.22.17.60.41.70.82.00.31.42.71.91.41.21.11.30.7
Time in novel zone, hab. session 12.12.15.1-1.0-1.7-1.0-1.9-0.4-1.7-2.3-1.9-1.5-1.2-1.2-1.3-0.5
Total zone transitions, hab. session 10.40.51.00.90.70.90.70.61.00.10.70.60.70.50.70.7
Total locomotion distance, hab. session 10.40.51.21.00.80.80.90.51.10.20.70.60.70.30.70.6
Locomotion velocity, hab. session 10.20.30.70.70.60.70.70.60.80.10.60.50.60.30.60.4
Time in familiar zone, hab. session 20.30.31.0-0.7-0.2-0.5-0.2-0.90.21.0-0.2-0.5-0.4-0.5-0.3-0.7
Time in novel zone, hab. session 20.10.10.4-0.2-0.1-0.1-0.10.4-0.7-0.3-0.10.20.00.2-0.00.6
Total zone transitions, hab. session 20.10.10.50.3-0.30.1-0.0-0.60.7-0.1-0.3-0.4-0.3-0.5-0.3-0.2
Total locomotion distance, hab. session 20.40.52.71.20.50.80.9-0.11.60.20.40.30.3-0.10.30.6
Locomotion velocity, hab. session 20.71.03.71.60.81.21.10.31.90.00.80.70.70.30.60.8
Novel to familiar place preference ratio0.30.30.90.30.60.50.50.50.30.20.60.60.60.70.61.0
Novelty place preference0.20.30.90.20.50.40.30.60.00.10.40.60.60.70.61.0
Time in novel zone, NPP test0.20.20.9-0.00.40.20.10.6-0.20.00.30.50.50.60.50.9
Total zone transitions, NPP test1.31.83.31.61.31.61.80.91.70.41.31.31.30.81.21.6
Total locomotion distance, NPP test1.01.33.61.51.11.21.90.31.60.61.11.00.90.40.81.4
Locomotion velocity, NPP test1.42.04.91.91.41.62.20.52.10.71.41.21.10.61.01.6
Intraocular pressure0.20.31.9-0.10.2-0.10.9-0.80.41.40.50.30.1-0.40.1-0.4
Delta distance traveled before/after self-admin0.70.83.0-1.6-0.7-1.0-1.20.4-1.7-0.1-0.7-0.3-0.40.0-0.4-0.7
Delta ambulatory time before/after self-admin0.60.72.1-1.4-0.8-0.9-1.40.4-1.5-0.5-0.9-0.4-0.5-0.0-0.4-0.6
Parametrial fat weight2.25.110.0-1.8-2.3-2.4-1.4-3.2-0.80.5-2.2-2.4-2.7-2.7-2.6-2.7
Pavlov. Cond. lever latency5.56.910.0-3.2-2.7-3.1-2.1-2.9-1.91.1-2.4-2.6-3.0-2.8-2.9-2.9
Pavlov. Cond. magazine entry latency3.03.87.32.11.92.20.92.71.2-0.71.82.02.22.52.21.9
Pavlov. Cond. change in total contacts1.51.63.41.41.21.40.41.90.6-0.81.11.21.41.71.41.0
Pavlov. Cond. index score4.65.89.13.02.32.81.53.01.8-1.22.22.32.72.82.62.4
Pavlov. Cond. latency score4.76.09.13.02.42.91.53.01.8-1.32.22.42.72.82.62.5
Pavlov. Cond. lever contacts4.04.78.83.02.12.71.72.41.7-1.41.82.02.42.22.22.3
Pavlov. Cond. magazine entry number2.12.64.7-1.7-1.6-1.8-0.9-2.2-1.00.6-1.5-1.6-1.9-2.0-1.8-1.6
Pavlov. Cond. intertrial magazine entries0.50.63.0-0.6-0.1-0.60.7-1.20.21.7-0.1-0.4-0.6-0.7-0.6-0.5
Pavlov. Cond. lever-magazine prob. diff.4.85.99.03.02.42.81.53.01.8-1.12.32.42.72.82.62.4
Pavlov. Cond. response bias3.34.16.52.52.02.41.22.61.5-1.01.81.92.22.42.11.9
Pavlov. Cond. lever latency0.40.52.00.1-0.9-0.2-0.8-0.4-0.2-1.4-0.8-0.7-0.6-0.7-0.7-0.5
Pavlov. Cond. magazine entry latency0.40.41.00.40.60.60.61.00.2-0.20.60.80.70.60.71.0
Pavlov. Cond. change in total contacts0.20.30.7-0.50.5-0.00.40.6-0.50.80.60.60.50.50.60.3
Pavlov. Cond. index score0.30.40.80.00.80.40.70.9-0.10.60.70.80.70.70.80.8
Pavlov. Cond. latency score0.20.30.6-0.20.60.20.50.7-0.20.60.50.60.50.50.60.6
Pavlov. Cond. lever contacts0.20.31.5-0.20.70.10.60.20.11.20.60.50.40.50.50.4
Pavlov. Cond. magazine entry number0.10.10.20.0-0.3-0.2-0.4-0.3-0.1-0.1-0.3-0.3-0.3-0.2-0.2-0.5
Pavlov. Cond. intertrial magazine entries0.40.61.51.20.71.00.11.10.7-0.80.50.50.90.90.90.4
Pavlov. Cond. lever-magazine prob. diff.0.30.30.60.00.70.30.60.7-0.00.50.70.70.60.70.60.7
Pavlov. Cond. response bias0.50.71.10.41.10.60.90.80.50.71.01.00.91.00.90.8
Time in closed arm before self-admin0.10.10.3-0.0-0.2-0.1-0.30.5-0.5-0.5-0.30.00.0-0.1-0.0-0.2
Time in closed arm after self-admin0.10.10.2-0.4-0.3-0.2-0.0-0.1-0.4-0.3-0.4-0.2-0.2-0.4-0.20.1
Time in open arm before self-admin1.21.32.30.71.31.10.81.40.80.21.21.41.31.51.31.2
Time in open arm after self-admin0.40.51.10.10.80.40.61.0-0.10.50.71.00.70.80.70.6
Bone: periosteal estimation1.53.17.1-1.4-2.0-1.3-2.5-0.3-2.2-2.7-2.2-1.7-1.4-1.3-1.4-1.3
Bone: periosteal perimeter0.40.74.50.2-0.8-0.0-1.40.4-0.6-2.1-0.8-0.6-0.30.1-0.4-0.5
Bone: post-yield work0.30.53.5-0.1-0.60.0-0.4-0.0-0.5-1.9-0.9-0.6-0.2-0.7-0.30.2
Progressive ratio test 1 active lever presses0.20.30.80.10.60.40.80.6-0.10.40.60.60.50.50.50.9
Progressive ratio test 1 breakpoint0.20.30.80.10.50.30.80.6-0.20.30.50.60.50.50.50.9
Progressive ratio test 1 inactive lever presses0.20.20.9-0.5-0.2-0.30.4-0.90.20.7-0.3-0.5-0.4-0.6-0.4-0.2
Progressive ratio test 2 active lever presses0.60.71.20.51.00.71.10.41.00.90.90.80.80.70.80.8
Progressive ratio test 2 breakpoint0.70.81.40.41.10.71.20.41.01.01.00.80.80.80.90.8
Progressive ratio test 2 inactive lever presses0.50.81.70.70.80.91.11.20.1-0.20.70.91.00.90.91.3
Incentive Sensitization - Responses0.40.61.50.70.90.80.70.61.20.40.70.70.90.70.90.6
Incentive Sensitization - Breakpoint0.50.61.70.60.90.70.80.51.30.50.70.70.80.60.90.5
Sum of active levers in priming session hrs 5-60.50.51.40.40.70.60.51.2-0.3-0.20.80.90.80.80.70.6
Progressive ratio5.07.911.0-3.3-3.0-3.1-2.9-2.9-2.5-0.1-3.1-2.9-2.9-2.8-2.8-2.7
Food seeking constrained by brief footshock0.10.10.6-0.50.3-0.20.30.2-0.20.80.20.30.10.40.2-0.1
Seeking ratio, punishment vs. effort3.95.67.52.52.52.52.22.71.80.12.62.52.62.62.52.3
Retroperitoneal fat weight0.10.51.4-0.2-0.6-0.6-0.0-1.20.30.3-0.5-0.8-0.9-0.9-1.0-1.0
Reaction time number correct1.01.94.1-2.0-1.2-1.7-0.5-1.8-1.21.2-1.2-1.3-1.3-1.4-1.2-1.2
Reaction time mean minus median1.02.44.22.01.51.91.21.71.3-0.71.31.51.71.51.61.5
Reaction time mean minus median AUC1.43.75.82.42.02.21.92.01.5-0.41.92.02.11.92.01.9
Reaction time num false alarms0.10.21.20.4-0.00.4-0.60.60.3-1.1-0.1-0.00.30.40.30.0
Reaction time num false alarms AUC0.20.31.70.2-0.20.2-1.00.70.0-1.3-0.3-0.20.20.40.2-0.1
Reaction time trials correct on left1.01.94.1-2.0-1.2-1.7-0.5-1.8-1.21.2-1.2-1.3-1.3-1.4-1.2-1.2
Reaction time trials on left1.01.84.0-2.0-1.1-1.7-0.5-1.7-1.21.1-1.2-1.3-1.3-1.4-1.2-1.2
Reaction time mean1.22.05.12.31.01.91.01.51.3-1.41.01.11.41.21.21.5
Reaction time mean AUC1.22.05.02.21.11.91.11.51.3-1.31.11.21.41.21.21.4
Median of all reaction times0.71.03.21.80.61.40.71.00.9-1.40.60.70.90.80.71.1
Reaction time omissions0.60.81.91.40.71.20.71.00.8-1.10.40.40.90.60.81.2
Reaction time false alarm rate0.91.23.41.40.61.2-0.51.80.7-1.80.50.81.01.31.00.7
Reaction time premature initiation rate0.30.41.0-0.8-0.7-0.8-0.4-0.4-1.0-0.2-0.8-0.5-0.7-0.9-0.7-0.3
Reaction time premature initiations1.22.24.0-2.0-1.5-1.8-0.9-1.4-1.70.4-1.5-1.4-1.5-1.7-1.5-1.2
Std. dev. reaction times1.52.75.22.21.42.00.92.31.0-1.41.31.51.81.81.71.6
Reaction time trials completed1.01.84.0-2.0-1.1-1.7-0.5-1.7-1.21.1-1.2-1.3-1.3-1.4-1.2-1.2
Reaction time trials AUC1.01.83.7-1.9-1.2-1.6-0.5-1.8-1.11.1-1.2-1.4-1.3-1.5-1.2-1.2
Run reversals in cocaine runway, females0.20.21.0-0.7-0.0-0.40.5-0.6-0.11.00.10.1-0.3-0.4-0.30.2
Run reversals in cocaine runway, males0.60.62.40.50.50.80.61.10.3-0.50.60.80.80.40.81.5
Latency to leave start box in cocaine runway0.60.62.71.60.61.10.40.70.9-1.10.40.40.60.60.50.5
Latency to leave start box in cocaine runway, F0.60.72.41.50.81.10.70.71.0-0.60.70.70.80.60.70.4
Latency to leave start box in cocaine runway, M0.20.20.90.5-0.30.1-0.5-0.20.1-0.9-0.6-0.5-0.3-0.1-0.3-0.1
Std. dev. time between licks in bursts0.71.06.80.80.10.9-0.51.6-0.3-2.6-0.30.20.70.50.60.7
Total sessions with >9 infusions0.40.50.8-0.20.70.30.70.8-0.20.80.80.90.70.90.70.9
Short access day 1 total inactive lever presses0.50.71.80.60.70.80.81.4-0.4-0.50.60.90.91.10.81.1
Short access day 10 total inactive lever presses0.10.21.30.4-0.20.4-0.1-0.21.2-0.7-0.4-0.30.0-0.2-0.00.2
Short access day 1 total infusions0.91.22.30.61.20.81.11.3-0.00.41.11.41.11.31.01.5
Short access day 10 total infusions0.50.71.50.31.00.51.20.50.41.11.11.00.80.70.80.9
Short access total infusions0.71.01.70.41.10.61.30.90.00.81.11.20.91.10.91.3
Short access day 1 locomotion0.70.91.91.00.91.10.90.81.4-0.00.90.91.00.71.01.0
Short access day 10 total locomotion1.42.55.2-1.5-1.9-1.3-2.3-0.2-1.7-2.0-1.9-1.7-1.2-1.3-1.3-1.1
Short access total locomotion0.20.20.8-0.3-0.6-0.2-0.50.2-0.5-0.9-0.5-0.4-0.2-0.4-0.30.1
One hour access (0.3 mA shock)1.41.74.71.31.31.51.20.72.20.51.21.21.31.01.31.4
Compulsive drug intake0.81.04.51.8-0.11.2-0.50.21.8-2.1-0.3-0.20.3-0.20.20.4
One hour access (shock baseline)0.60.93.8-0.31.00.21.30.20.42.01.11.10.70.80.80.6
Social response proportion0.60.71.9-0.4-0.9-0.6-1.2-0.1-1.3-1.4-0.8-0.6-0.7-0.2-0.8-0.4
Social responses0.50.61.8-0.3-0.8-0.6-1.30.3-1.2-1.1-0.7-0.6-0.7-0.0-0.7-0.9
Social time0.70.95.01.40.01.1-0.51.10.9-2.2-0.20.10.50.50.40.7
Soleus weight0.72.218.30.8-1.20.4-1.81.0-0.9-4.3-1.4-0.6-0.3-0.2-0.50.4
Bone: stiffness1.01.63.5-1.0-1.2-1.2-1.0-1.9-0.30.1-1.4-1.6-1.4-1.4-1.4-1.5
Tibialis anterior weight0.10.51.0-0.6-0.4-0.7-0.3-1.0-0.01.0-0.4-0.6-0.8-0.7-0.7-1.0
Time to tail flick, vehicle, before self-admin0.50.52.51.0-0.20.3-0.5-1.01.6-0.2-0.0-0.7-0.4-0.4-0.3-1.2
Time to tail flick, vehicle, after self-admin0.40.61.11.00.60.90.31.00.6-0.40.60.70.80.90.80.7
Time to tail flick, test, before self-admin0.10.10.4-0.10.30.1-0.1-0.40.60.60.1-0.00.10.20.2-0.4
Time to tail flick, test, after self-admin2.32.43.91.12.01.51.81.11.61.11.71.71.71.51.71.2
Delta time to tail flick, vehicle, before/after SA2.12.03.80.71.61.01.71.40.21.01.51.71.41.61.41.9
Delta time to tail flick, test, before/after SA0.40.41.50.70.80.61.20.10.80.60.70.60.50.20.50.6
Tibia length1.85.09.3-1.9-2.6-1.7-2.8-0.8-2.5-3.1-2.8-2.3-1.8-2.3-2.0-1.4
Ambulatory time before self-admin0.10.10.40.2-0.10.00.1-0.40.2-0.2-0.1-0.3-0.2-0.6-0.2-0.2
Ambulatory time after self-admin1.01.22.1-1.1-1.2-1.1-1.4-0.5-1.4-0.9-1.3-1.1-1.0-1.0-1.0-1.0
Bone: tissue strength0.20.20.4-0.5-0.4-0.40.0-0.4-0.60.0-0.4-0.4-0.4-0.6-0.5-0.0
Total heroin consumption0.00.00.20.1-0.10.2-0.30.20.2-0.4-0.10.00.00.00.0-0.2
Bone: trabecular number1.62.77.01.21.91.32.7-0.42.42.31.71.31.30.51.31.5
Bone: trabecular spacing2.33.17.0-1.3-2.1-1.5-2.7-0.1-2.5-2.0-1.8-1.5-1.5-0.9-1.5-1.7
Bone: trabecular thickness0.81.03.10.71.10.61.8-0.61.71.60.90.60.6-0.00.60.6
Bone: trabecular tissue density0.10.20.6-0.70.2-0.1-0.10.5-0.60.00.00.20.50.30.60.7
Water consumed over 24 hours0.10.10.90.4-0.10.2-0.50.40.0-0.9-0.2-0.00.00.2-0.00.3
Number of responses in last shaping day0.60.73.30.0-0.30.2-0.91.5-1.3-1.8-0.40.20.30.60.20.6