Hub : Genes

Pax6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Pax6 0.02 0.02 4.3e-03 0.04 0.03 0.02 0.03 4.7e-04 2.4e-03 5.6e-03 9.4e-04
2 NAcc isoform ratio XM_039104376.2 0.02 0.02 1.4e-04 0.02 0.02 0.02 0.02 3.3e-04 2.9e-04 3.3e-04 4.4e-04
3 NAcc alternative TSS XM_039104376.2 0.02 0.02 1.2e-04 0.02 0.03 0.02 0.02 2.8e-04 7.4e-05 1.2e-04 1.8e-04
4 pVTA intron excision ratio chr3_112591485_112594383 0.03 0.03 1.8e-03 0.03 0.03 0.03 0.03 1.2e-03 1.9e-03 3.1e-03 8.6e-04
5 pVTA intron excision ratio chr3_112590623_112594383 0.03 0.03 1.4e-03 0.03 0.03 0.03 0.04 9.5e-04 1.6e-03 3.5e-03 5.9e-04
6 pVTA alternative TSS XM_039104376.2 0.03 0.02 4.5e-03 0.01 0.03 0.02 0.02 2.3e-02 3.3e-03 1.5e-02 1.3e-02
7 pVTA isoform ratio XM_039104376.2 0.03 0.02 5.2e-03 0.01 0.03 0.02 0.02 3.7e-02 4.2e-03 7.8e-03 1.5e-02
8 Brain gene expression Pax6 0.2 0.11 2.5e-14 0.14 0.16 0.16 0.16 3.5e-13 1.3e-14 2.4e-14 1.9e-14
9 Eye alternative TSS NM_013001.2 0.35 0.26 8.6e-03 0.02 0.03 -0.01 0 1.7e-01 1.4e-01 4.7e-01 3.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.91.62.41.11.11.11.3-1.31.21.2-1.6-1.4
Area under the delay curve0.10.20.4-0.5-0.2-0.2-0.60.6-0.1-0.0-0.6-0.2
BMI with tail0.10.30.80.20.30.30.9-0.90.40.4-0.5-0.4
BMI without tail0.61.85.00.80.90.91.3-1.31.11.3-2.2-1.7
Body weight1.14.89.01.61.91.92.0-2.12.12.2-3.0-2.6
Weight adjusted by age0.10.20.9-0.2-0.3-0.2-0.50.5-0.10.1-1.0-0.5
Bone surface0.61.02.40.70.80.80.9-0.90.91.0-1.6-1.2
Bone volume1.22.23.91.31.31.31.4-1.41.41.5-2.0-1.7
Breakpoint value in progressive ratio session1.21.41.7-1.1-1.3-1.2-1.11.2-1.2-1.21.11.1
Number of licking bursts0.20.40.50.50.60.70.5-0.50.70.7-0.7-0.7
Context. condit. distance diff. score4.35.15.72.42.32.32.2-2.22.32.3-2.0-2.2
Locomotion velocity, session 11.71.82.0-1.3-1.3-1.4-1.31.3-1.4-1.41.31.4
Locomotion distance, session 10.20.30.5-0.4-0.4-0.5-0.40.5-0.5-0.50.70.6
Locomotion velocity, session 20.00.00.10.00.0-0.00.1-0.1-0.0-0.10.20.1
Locomotion distance, session 20.00.10.2-0.1-0.1-0.1-0.10.1-0.2-0.20.50.3
Locomotion velocity, session 30.00.00.10.20.30.30.2-0.20.20.2-0.1-0.2
Locomotion distance, session 30.00.00.10.10.20.20.0-0.00.20.2-0.1-0.2
Stereotopy head waving bouts, day 30.10.20.2-0.4-0.4-0.4-0.50.5-0.4-0.40.30.3
Stereotopy head waving duration, day 30.10.20.20.50.40.40.5-0.40.40.4-0.3-0.4
Locomotion velocity, session 70.20.20.30.40.40.40.4-0.30.40.4-0.5-0.5
Locomotion distance, session 70.10.10.2-0.3-0.3-0.3-0.50.5-0.2-0.20.10.1
Stereotopy head waving bouts, day 70.30.41.3-0.4-0.4-0.4-0.20.3-0.5-0.61.20.8
Stereotopy head waving duration, day 70.10.20.4-0.4-0.3-0.3-0.20.2-0.4-0.40.70.5
Locomotion velocity, session 80.30.30.50.70.60.60.6-0.60.60.6-0.5-0.5
Locomotion distance, session 82.33.33.92.01.91.91.9-1.81.91.8-1.4-1.7
Degree of sensitization distance0.20.20.2-0.4-0.5-0.5-0.40.4-0.5-0.40.30.4
Degree of sensitization stereotypy0.50.51.1-0.7-0.6-0.6-0.50.5-0.7-0.71.10.9
Conditioned locomotion5.66.57.7-2.7-2.7-2.6-2.82.7-2.5-2.52.12.3
Cocaine response after cond. corrected4.14.96.5-2.0-2.1-2.1-2.12.1-2.2-2.32.62.4
Cocaine response after cond. not corrected1.31.52.5-1.1-1.1-1.1-1.11.1-1.2-1.31.61.4
Cocaine response before conditioning5.86.97.72.52.62.72.5-2.52.72.7-2.7-2.8
Saline control response0.10.20.20.40.30.40.4-0.30.40.4-0.4-0.4
Bone: connectivity density0.71.11.41.01.01.01.2-1.21.01.0-1.0-1.0
Bone: cortical apparent density0.00.10.10.30.30.20.3-0.30.20.20.1-0.1
Bone: cortical area1.11.73.01.11.21.21.0-1.11.31.4-1.7-1.5
Bone: cortical porosity0.20.20.3-0.5-0.5-0.5-0.60.6-0.4-0.40.30.3
Bone: cortical porosity0.10.10.2-0.4-0.3-0.3-0.40.4-0.2-0.1-0.2-0.0
Bone: cortical thickness0.10.10.30.40.30.30.3-0.30.40.4-0.5-0.5
Bone: cortical thickness1.51.72.2-1.5-1.3-1.3-1.51.4-1.3-1.31.01.1
Bone: cortical tissue density0.00.00.10.30.20.20.3-0.30.20.10.1-0.0
Condit. Reinf. active minus inactive responses2.22.52.71.71.61.61.6-1.61.61.6-1.4-1.5
Condit. Reinf. active-inactive response ratio6.77.27.72.82.72.72.7-2.72.72.7-2.4-2.6
Condit. Reinf. active responses0.40.50.50.70.60.60.7-0.70.70.7-0.7-0.7
Condit. Reinf. inactive responses1.72.12.6-1.5-1.6-1.6-1.51.4-1.5-1.51.11.3
Incentive salience index mean1.41.71.91.41.31.31.3-1.31.31.3-1.2-1.3
Condit. Reinf. lever presses0.30.40.40.70.60.60.6-0.60.60.6-0.6-0.6
Condit. Reinf. active minus inactive responses1.82.32.41.51.61.61.5-1.51.61.6-1.4-1.5
Condit. Reinf. active-inactive response ratio4.55.25.92.42.32.32.4-2.32.32.3-1.9-2.1
Condit. Reinf. active responses1.31.82.21.21.31.31.2-1.21.41.4-1.5-1.4
Condit. Reinf. inactive responses0.00.10.3-0.3-0.1-0.1-0.20.10.00.1-0.5-0.3
Condit. Reinf. lever presses2.23.04.41.41.71.71.6-1.61.71.8-2.1-1.9
Condit. Reinf. lever reinforcers received1.41.92.41.21.41.41.3-1.31.41.4-1.5-1.5
Conditioned reinforcement - actives2.84.86.82.62.52.52.1-2.22.42.2-1.1-1.8
Conditioned reinforcement - inactives6.19.011.73.03.43.43.1-3.23.23.0-1.9-2.6
Conditioned locomotion3.84.96.42.52.42.32.3-2.32.22.2-1.6-2.0
Patch foraging indifference point 0 sec0.00.10.2-0.10.20.20.4-0.40.20.2-0.2-0.1
Patch foraging indifference point AUC1.31.83.6-1.1-1.2-1.2-1.01.1-1.3-1.41.91.7
Delay disc. indifference point, 0s delay0.30.30.80.40.50.50.3-0.40.50.6-0.9-0.7
Delay disc. indifference point, 16s delay0.50.51.1-0.9-0.7-0.7-1.01.0-0.6-0.5-0.20.2
Delay disc. indifference point, 2s delay0.30.40.90.50.50.50.5-0.50.50.6-0.9-0.7
Delay disc. indifference point, 24s delay0.70.81.7-1.0-0.7-0.7-1.31.3-0.7-0.70.60.6
Delay disc. indifference point, 4s delay0.20.20.5-0.7-0.5-0.5-0.60.6-0.4-0.3-0.30.0
Delay disc. indifference point, 8s delay0.10.20.7-0.20.10.1-0.40.30.20.3-0.9-0.6
Indifference point function ln k0.91.53.80.71.01.10.5-0.71.21.3-1.9-1.7
Indifference point function log k0.91.53.80.71.01.10.5-0.71.21.3-1.9-1.7
Patch foraging total patch changes 0 sec0.00.10.2-0.10.30.20.4-0.40.20.2-0.4-0.2
Patch foraging total patch changes 12 sec0.50.61.90.90.70.61.4-1.20.50.40.0-0.1
Patch foraging total patch changes 18 sec0.10.10.3-0.1-0.1-0.20.4-0.3-0.3-0.30.60.5
Patch foraging total patch changes 24 sec0.10.10.7-0.00.10.00.3-0.20.10.2-0.8-0.4
Patch foraging total patch changes 6 sec0.00.00.1-0.1-0.0-0.10.3-0.2-0.1-0.10.10.1
Patch foraging time to switch 0 sec0.30.71.10.90.80.81.0-1.00.80.8-0.5-0.6
Patch foraging water rate 0 sec0.00.10.2-0.30.10.0-0.20.20.10.1-0.4-0.3
Patch foraging water rate 12 sec0.20.41.9-0.6-0.1-0.1-0.50.40.10.3-1.4-0.8
Patch foraging water rate 18 sec0.60.92.50.70.70.80.5-0.60.91.0-1.6-1.3
Patch foraging water rate 24 sec0.40.52.20.20.30.30.2-0.30.50.7-1.5-1.0
Patch foraging water rate 6 sec0.10.20.7-0.4-0.2-0.2-0.40.3-0.00.1-0.9-0.5
Seeking ratio, delayed vs. immediate footshock0.70.94.10.10.50.50.2-0.20.70.9-2.0-1.4
Distance traveled before self-admin0.00.00.10.20.20.20.00.10.20.20.0-0.1
Distance traveled after self-admin1.01.22.70.80.90.90.9-0.81.11.2-1.6-1.4
Extensor digitorum longus weight0.10.20.3-0.6-0.6-0.6-0.50.5-0.5-0.50.10.3
Bone: elastic displacement0.60.71.0-0.7-0.8-0.8-0.80.8-0.8-0.91.00.9
Bone: elastic work0.00.00.1-0.00.00.00.0-0.10.00.1-0.3-0.2
Bone: endosteal estimation0.00.10.3-0.2-0.1-0.1-0.20.2-0.00.1-0.6-0.3
Bone: endosteal perimeter0.51.02.40.70.90.90.7-0.81.01.1-1.5-1.3
Epididymis fat weight1.96.69.72.12.42.42.6-2.62.52.6-3.1-2.8
Delta time in closed arm before/after self-admin0.10.10.20.0-0.2-0.30.0-0.1-0.3-0.30.40.4
Delta time in open arm before/after self-admin0.40.40.7-0.8-0.5-0.5-0.80.8-0.5-0.50.50.5
Diff in mean of infusions in LGA sessions0.10.20.3-0.6-0.5-0.5-0.40.4-0.4-0.40.30.4
Delay discount exponential model param0.20.20.50.60.30.30.7-0.70.20.10.50.2
Extinction: sum of active levers before priming0.10.10.1-0.3-0.4-0.3-0.00.1-0.3-0.30.30.3
Active lever presses in extinction session 60.40.40.50.70.50.60.5-0.40.70.7-0.5-0.7
Bone: final force0.71.12.30.90.90.91.0-1.01.01.1-1.5-1.2
Bone: final moment0.60.92.10.70.80.80.8-0.80.91.0-1.4-1.2
Food consumed during 24 hour testing period3.24.34.92.12.22.22.2-2.22.12.1-1.7-1.9
Glucose2.13.43.61.91.81.81.8-1.81.81.8-1.8-1.9
Heart weight0.30.42.2-0.5-0.6-0.5-0.30.3-0.10.1-1.5-0.7
Delay discount hyperbolic model param0.20.20.40.60.40.40.6-0.70.30.10.50.1
Intermittent access intake day 1-15 change0.61.32.01.41.31.31.4-1.41.21.0-0.1-0.6
Intermittent access intake escalation0.71.42.21.41.41.41.5-1.41.21.00.0-0.6
Intermittent access intake escalation 21.21.42.51.41.21.21.6-1.41.21.1-0.5-0.8
Intermitt. access day 1 inactive lever presses0.51.72.91.71.51.61.1-1.11.51.3-0.6-1.1
Intermitt. access day 15 inactive lever presses0.30.51.00.91.01.00.3-0.40.90.8-0.1-0.6
Intermitt. access escalation Index0.71.02.0-0.7-1.0-1.0-0.80.8-1.0-1.11.41.2
Intermittent access day 1 total infusions1.32.03.11.81.71.71.1-1.21.61.5-0.7-1.2
Intermittent access day 15 total infusions2.23.35.02.22.12.21.8-1.82.01.7-0.5-1.3
Intermittent access terminal intake (last 3 days)2.12.73.81.92.02.01.6-1.61.81.6-0.7-1.3
Intermittent access total infusions2.42.83.81.91.91.91.6-1.61.81.7-1.0-1.5
Intermittent access day 1 locomotion1.51.93.01.71.71.71.1-1.11.51.4-0.7-1.2
Intermittent access day 15 total locomotion0.40.71.41.21.11.00.7-0.60.90.8-0.3-0.7
Intermittent access total locomotion1.82.23.92.01.81.81.3-1.31.61.4-0.4-1.0
Intermittent access standard deviation1.32.84.12.01.71.71.9-1.81.61.6-1.0-1.4
Left kidney weight1.46.710.72.02.42.42.3-2.42.62.7-3.3-3.0
Right kidney weight2.611.920.22.83.13.13.1-3.23.33.6-4.5-4.0
Cocaine induced anxiety0.40.61.40.70.70.70.4-0.50.70.8-1.2-1.0
Post-drug Anxiety0.30.31.2-0.5-0.3-0.2-0.80.7-0.10.1-1.1-0.6
Baseline Anxiety1.72.03.7-1.9-1.6-1.5-1.71.6-1.3-1.1-0.10.6
Tail length0.93.512.01.01.31.40.9-1.01.62.0-3.5-2.6
Length with tail1.98.316.72.42.52.62.2-2.32.83.0-4.1-3.5
Length without tail1.65.25.52.22.22.22.3-2.32.32.3-2.3-2.3
Times rat made contact with spout0.40.40.60.80.70.70.8-0.80.70.6-0.3-0.5
Lifetime Intake1.82.23.31.81.81.81.5-1.51.61.4-0.5-1.1
Liver weight, left4.27.012.22.22.42.42.3-2.32.62.8-3.5-3.1
Liver weight, right2.13.74.71.81.81.81.9-1.91.92.0-2.2-2.1
Locomotor activity0.00.10.2-0.4-0.2-0.2-0.20.2-0.2-0.20.40.3
Locomotor testing distance1.42.52.91.51.71.71.5-1.51.71.6-1.3-1.6
Locomotor testing rearing0.30.70.90.80.80.80.9-0.80.80.8-0.7-0.8
Locomotion in novel chamber1.31.63.31.11.11.10.8-0.91.31.4-1.8-1.6
Locomotion in novel chamber post-restriction0.50.81.1-0.8-1.0-1.0-0.90.9-1.0-1.00.70.9
Fecal boli incidents, locomotor time 14.05.96.6-2.5-2.6-2.6-2.52.5-2.5-2.41.92.2
Change in fecal boli incidents, locomotor task2.62.53.11.61.51.61.3-1.41.61.6-1.8-1.7
Time >=10cm from walls, locomotor time 11.31.41.5-1.2-1.2-1.2-1.11.2-1.2-1.21.21.2
Bouts of movement, locomotor time 10.40.41.5-0.6-0.5-0.5-0.20.4-0.6-0.71.20.9
Total resting periods, locomotor time 10.70.82.3-0.8-0.7-0.7-0.40.5-0.8-0.91.51.2
Rest time, locomotor task time 13.64.54.9-2.2-2.2-2.2-2.01.9-2.2-2.22.02.2
Distance moved, locomotor task time 11.62.43.01.71.61.61.5-1.41.61.5-1.3-1.5
Vertical activity count, locomotor time 10.30.81.30.80.80.80.7-0.60.90.9-1.2-1.0
Time >=10cm from walls, locomotor time 21.62.43.41.31.51.61.2-1.31.61.7-1.8-1.8
Bouts of movement, locomotor time 20.81.31.81.21.21.21.3-1.41.11.1-0.7-0.9
Total resting periods, locomotor time 20.71.21.91.31.21.21.3-1.41.11.0-0.4-0.7
Rest time, locomotor task time 24.45.610.2-1.9-2.1-2.2-1.92.0-2.3-2.53.22.8
Distance moved, locomotor task time 23.13.74.71.71.91.91.9-1.81.92.0-2.2-2.1
Vertical activity count, locomotor time 23.54.97.71.92.02.02.0-2.02.22.3-2.8-2.5
Light reinforcement 10.10.20.30.30.50.50.4-0.50.50.5-0.6-0.5
Light reinforcement 20.71.01.8-0.8-0.9-0.9-1.00.9-1.0-1.11.31.2
Bone: marrow area0.00.10.3-0.2-0.1-0.1-0.20.2-0.00.1-0.5-0.3
Bone: maximum diameter0.40.71.30.70.80.80.6-0.70.80.9-1.2-1.0
Bone: maximum force1.32.43.91.31.41.41.4-1.41.51.6-2.0-1.7
Bone: maximum moment1.01.73.31.11.11.11.1-1.21.21.3-1.8-1.5
Mean time between licks in bursts0.10.40.5-0.7-0.7-0.7-0.70.6-0.6-0.60.40.5
Mean num. licks in bursts0.00.10.20.1-0.1-0.10.1-0.1-0.2-0.20.50.3
Cd content in liver1.82.02.41.51.51.41.6-1.51.41.3-1.1-1.2
Co content in liver1.31.51.6-1.2-1.2-1.2-1.21.2-1.2-1.31.21.3
Cu content in liver1.72.02.2-1.4-1.4-1.4-1.41.4-1.4-1.41.51.4
Fe content in liver0.00.00.1-0.1-0.1-0.1-0.10.1-0.1-0.20.30.2
K content in liver0.70.71.0-1.0-0.9-0.9-1.01.0-0.8-0.70.30.6
Mg content in liver0.20.20.3-0.5-0.4-0.4-0.50.5-0.4-0.30.10.2
Mn content in liver1.21.31.4-1.2-1.1-1.1-1.21.2-1.1-1.11.01.1
Na content in liver0.80.91.00.91.01.00.9-0.91.01.0-0.8-0.9
Rb content in liver1.61.82.2-1.3-1.3-1.3-1.31.3-1.3-1.41.51.4
Se content in liver3.33.95.2-2.3-2.2-2.1-2.32.2-2.0-1.91.11.6
Sr content in liver0.00.00.0-0.0-0.1-0.1-0.00.0-0.1-0.0-0.1-0.0
Zn content in liver0.10.10.2-0.2-0.2-0.2-0.20.2-0.2-0.20.40.3
Bone: minimum diameter2.03.65.01.81.81.81.7-1.81.92.0-2.2-2.1
Time in familiar zone, hab. session 11.11.11.3-1.1-1.0-1.0-1.11.1-1.0-1.01.01.0
Time in novel zone, hab. session 11.91.92.21.51.41.41.4-1.41.41.4-1.3-1.3
Total zone transitions, hab. session 11.62.22.51.51.61.61.6-1.51.51.5-1.2-1.4
Total locomotion distance, hab. session 10.30.40.60.70.70.70.8-0.70.70.6-0.1-0.4
Locomotion velocity, hab. session 10.20.30.50.60.60.60.7-0.60.50.5-0.1-0.3
Time in familiar zone, hab. session 20.20.20.3-0.5-0.5-0.5-0.50.5-0.5-0.50.30.4
Time in novel zone, hab. session 20.30.30.40.50.50.50.5-0.50.50.5-0.7-0.6
Total zone transitions, hab. session 20.20.30.40.50.60.60.6-0.60.60.5-0.1-0.3
Total locomotion distance, hab. session 20.60.71.0-0.9-0.8-0.8-0.80.8-0.8-0.91.00.9
Locomotion velocity, hab. session 20.50.61.0-0.8-0.7-0.7-0.70.7-0.7-0.81.00.9
Novel to familiar place preference ratio2.93.13.92.01.91.81.9-1.91.81.7-1.3-1.5
Novelty place preference3.13.34.22.01.91.92.0-2.01.81.8-1.3-1.6
Time in novel zone, NPP test2.62.73.41.91.71.71.8-1.81.71.6-1.2-1.4
Total zone transitions, NPP test1.92.73.0-1.7-1.6-1.6-1.71.7-1.6-1.61.51.6
Total locomotion distance, NPP test2.33.13.6-1.8-1.8-1.8-1.91.9-1.8-1.71.51.6
Locomotion velocity, NPP test1.92.73.1-1.7-1.7-1.7-1.81.8-1.7-1.61.41.5
Intraocular pressure0.50.81.9-0.7-0.7-0.8-0.50.5-0.9-1.01.41.2
Delta distance traveled before/after self-admin0.10.10.30.00.20.20.1-0.10.30.3-0.6-0.4
Delta ambulatory time before/after self-admin0.50.61.20.50.60.70.9-0.90.70.8-1.1-0.9
Parametrial fat weight0.00.00.10.3-0.1-0.10.3-0.4-0.1-0.10.20.2
Pavlov. Cond. lever latency0.20.20.4-0.6-0.5-0.6-0.50.4-0.5-0.50.20.4
Pavlov. Cond. magazine entry latency0.91.11.41.21.11.11.1-1.11.01.0-0.9-1.0
Pavlov. Cond. change in total contacts0.00.00.0-0.0-0.1-0.1-0.10.1-0.1-0.0-0.2-0.1
Pavlov. Cond. index score0.10.20.30.50.40.40.4-0.40.40.4-0.4-0.4
Pavlov. Cond. latency score0.20.20.40.60.50.50.5-0.40.50.4-0.3-0.4
Pavlov. Cond. lever contacts0.30.30.40.70.60.60.5-0.50.60.6-0.4-0.5
Pavlov. Cond. magazine entry number1.11.41.7-1.3-1.2-1.2-1.21.2-1.2-1.21.11.1
Pavlov. Cond. intertrial magazine entries0.20.20.50.30.40.40.2-0.30.40.5-0.7-0.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.40.30.30.3-0.30.30.3-0.3-0.3
Pavlov. Cond. response bias0.60.71.01.00.80.90.9-0.90.80.8-0.6-0.7
Pavlov. Cond. lever latency2.12.94.6-1.5-1.5-1.5-1.61.6-1.6-1.72.11.9
Pavlov. Cond. magazine entry latency1.01.21.41.21.11.11.2-1.11.11.1-1.0-1.0
Pavlov. Cond. change in total contacts0.50.81.40.70.80.80.8-0.80.80.9-1.2-1.0
Pavlov. Cond. index score2.43.24.51.71.71.71.7-1.71.71.8-2.1-2.0
Pavlov. Cond. latency score2.22.94.31.61.61.61.6-1.61.71.7-2.1-1.9
Pavlov. Cond. lever contacts3.04.15.61.91.91.92.0-1.92.02.1-2.4-2.2
Pavlov. Cond. magazine entry number1.51.82.1-1.4-1.3-1.3-1.41.3-1.3-1.31.51.4
Pavlov. Cond. intertrial magazine entries0.10.10.6-0.20.10.1-0.30.20.20.3-0.8-0.5
Pavlov. Cond. lever-magazine prob. diff.2.12.83.91.61.51.51.6-1.61.61.7-2.0-1.8
Pavlov. Cond. response bias3.14.25.02.02.01.92.1-2.02.02.1-2.2-2.1
Time in closed arm before self-admin4.05.16.22.42.42.42.5-2.42.42.2-1.5-2.0
Time in closed arm after self-admin3.73.95.52.32.02.02.4-2.31.91.8-1.3-1.6
Time in open arm before self-admin3.53.85.5-2.3-2.2-2.2-2.22.1-2.0-1.80.61.4
Time in open arm after self-admin5.76.29.2-2.7-2.6-2.5-3.03.0-2.4-2.31.51.9
Bone: periosteal estimation0.20.41.50.40.50.50.3-0.40.50.7-1.2-0.9
Bone: periosteal perimeter0.91.62.61.11.21.21.0-1.11.31.3-1.6-1.5
Bone: post-yield work0.00.10.30.00.10.10.1-0.10.10.2-0.6-0.4
Progressive ratio test 1 active lever presses1.21.52.31.51.51.41.1-1.21.31.2-0.5-0.9
Progressive ratio test 1 breakpoint1.11.42.11.41.41.41.1-1.21.21.1-0.5-0.9
Progressive ratio test 1 inactive lever presses0.91.32.41.31.51.51.0-1.21.31.10.2-0.6
Progressive ratio test 2 active lever presses4.04.76.52.52.52.52.1-2.12.32.1-1.1-1.8
Progressive ratio test 2 breakpoint4.14.76.42.52.52.52.1-2.12.32.1-1.1-1.8
Progressive ratio test 2 inactive lever presses3.76.18.32.52.92.92.3-2.42.72.5-1.6-2.2
Incentive Sensitization - Responses1.52.13.21.71.81.81.5-1.41.61.40.0-0.9
Incentive Sensitization - Breakpoint1.62.03.21.61.71.81.5-1.41.61.4-0.0-0.9
Sum of active levers in priming session hrs 5-62.92.74.2-1.7-1.7-1.7-2.02.1-1.5-1.51.01.3
Progressive ratio0.30.50.80.90.80.80.8-0.80.70.6-0.0-0.4
Food seeking constrained by brief footshock0.00.00.10.30.30.30.2-0.10.20.10.40.1
Seeking ratio, punishment vs. effort0.10.20.3-0.6-0.5-0.5-0.40.4-0.5-0.50.30.5
Retroperitoneal fat weight20.185.792.99.69.49.49.6-9.69.39.2-8.2-8.9
Reaction time number correct0.20.31.3-0.8-0.3-0.3-0.60.5-0.10.1-1.1-0.5
Reaction time mean minus median0.00.00.1-0.1-0.2-0.2-0.10.1-0.2-0.1-0.3-0.1
Reaction time mean minus median AUC0.00.10.4-0.1-0.0-0.0-0.00.00.00.1-0.6-0.3
Reaction time num false alarms1.52.13.4-1.7-1.5-1.5-1.81.7-1.4-1.30.51.0
Reaction time num false alarms AUC2.23.45.6-2.1-1.9-1.9-2.42.2-1.8-1.60.81.3
Reaction time trials correct on left0.20.31.3-0.8-0.3-0.3-0.60.5-0.10.1-1.1-0.5
Reaction time trials on left0.20.31.1-0.8-0.4-0.3-0.70.5-0.20.0-1.1-0.5
Reaction time mean0.30.50.70.80.60.60.8-0.90.60.6-0.8-0.6
Reaction time mean AUC0.40.70.90.90.70.70.9-1.00.70.8-0.9-0.8
Median of all reaction times0.60.81.31.10.80.81.1-1.10.80.8-0.8-0.8
Reaction time omissions0.20.20.3-0.6-0.5-0.5-0.30.3-0.6-0.50.50.6
Reaction time false alarm rate2.12.94.1-1.7-1.8-1.7-2.01.9-1.7-1.61.31.5
Reaction time premature initiation rate0.10.10.30.3-0.0-0.00.3-0.2-0.1-0.20.60.4
Reaction time premature initiations0.00.10.1-0.2-0.3-0.3-0.20.1-0.3-0.30.20.3
Std. dev. reaction times0.10.20.60.30.20.20.3-0.40.20.3-0.8-0.5
Reaction time trials completed0.20.31.1-0.8-0.4-0.3-0.70.5-0.20.0-1.1-0.5
Reaction time trials AUC0.10.31.2-0.7-0.2-0.2-0.50.4-0.10.1-1.1-0.6
Run reversals in cocaine runway, females1.81.82.11.21.31.41.2-1.21.41.4-1.4-1.4
Run reversals in cocaine runway, males0.20.21.0-0.1-0.3-0.3-0.20.1-0.4-0.51.00.7
Latency to leave start box in cocaine runway1.21.31.9-1.0-1.1-1.0-1.31.3-1.0-1.11.41.2
Latency to leave start box in cocaine runway, F0.80.91.3-0.8-0.9-0.8-1.11.1-0.8-0.91.00.9
Latency to leave start box in cocaine runway, M0.20.20.4-0.2-0.4-0.3-0.50.5-0.3-0.40.70.5
Std. dev. time between licks in bursts0.81.12.80.70.90.90.8-0.81.01.1-1.7-1.3
Total sessions with >9 infusions0.70.81.50.91.21.21.0-1.10.90.80.0-0.4
Short access day 1 total inactive lever presses0.91.11.61.21.21.21.3-1.31.11.0-0.3-0.7
Short access day 10 total inactive lever presses0.20.60.90.90.70.70.6-0.70.70.8-0.8-0.8
Short access day 1 total infusions1.92.54.41.81.91.82.1-2.11.41.20.1-0.6
Short access day 10 total infusions0.81.11.81.11.31.31.2-1.21.00.90.1-0.5
Short access total infusions0.60.81.51.11.21.21.0-1.00.90.70.4-0.2
Short access day 1 locomotion1.21.52.51.61.31.31.6-1.51.11.0-0.4-0.7
Short access day 10 total locomotion0.91.63.11.81.51.61.4-1.31.31.00.3-0.6
Short access total locomotion1.31.52.31.51.51.51.2-1.21.31.2-0.7-1.0
One hour access (0.3 mA shock)3.54.06.12.52.22.22.2-2.22.11.9-0.7-1.4
Compulsive drug intake2.53.03.7-1.5-1.9-1.9-1.41.4-1.8-1.81.71.9
One hour access (shock baseline)4.16.27.92.72.82.82.5-2.52.72.5-1.6-2.2
Social response proportion3.23.74.6-1.9-1.9-2.0-2.12.1-2.0-1.91.41.7
Social responses0.20.20.5-0.7-0.5-0.5-0.60.6-0.5-0.3-0.40.0
Social time6.38.69.3-3.0-2.9-3.0-2.82.9-3.0-3.02.83.0
Soleus weight0.20.60.9-0.9-0.9-0.9-0.90.9-0.8-0.80.40.6
Bone: stiffness1.82.93.71.61.71.61.7-1.71.61.7-1.9-1.8
Tibialis anterior weight1.44.75.2-2.3-2.2-2.2-2.22.2-2.2-2.21.92.1
Time to tail flick, vehicle, before self-admin0.40.41.00.60.50.51.0-1.00.60.5-0.2-0.3
Time to tail flick, vehicle, after self-admin2.83.74.61.82.12.12.1-2.12.01.9-1.4-1.7
Time to tail flick, test, before self-admin1.11.12.21.51.11.11.3-1.21.00.9-0.1-0.6
Time to tail flick, test, after self-admin1.51.52.71.61.41.41.3-1.31.31.1-0.2-0.8
Delta time to tail flick, vehicle, before/after SA1.21.21.80.71.11.10.8-0.81.11.2-1.4-1.3
Delta time to tail flick, test, before/after SA0.10.10.2-0.4-0.3-0.3-0.50.4-0.3-0.30.20.2
Tibia length0.10.40.6-0.5-0.6-0.6-0.50.5-0.7-0.70.80.7
Ambulatory time before self-admin0.00.00.00.10.10.1-0.10.10.20.1-0.1-0.1
Ambulatory time after self-admin0.91.11.71.01.01.00.8-0.71.11.2-1.3-1.3
Bone: tissue strength0.30.30.6-0.5-0.6-0.6-0.40.5-0.6-0.60.80.7
Total heroin consumption0.70.81.1-1.0-0.9-0.8-0.80.9-0.8-0.91.10.9
Bone: trabecular number0.71.22.30.90.90.91.1-1.11.01.1-1.5-1.3
Bone: trabecular spacing0.10.10.40.20.10.1-0.10.10.0-0.10.70.3
Bone: trabecular thickness0.70.81.60.80.80.80.8-0.80.90.9-1.3-1.1
Bone: trabecular tissue density0.40.60.8-0.9-0.7-0.7-0.80.9-0.7-0.70.70.7
Water consumed over 24 hours0.81.01.31.11.11.11.1-1.11.01.0-0.7-0.8
Number of responses in last shaping day3.64.05.12.22.32.32.1-2.12.12.0-1.1-1.6