Pan2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Pan2	0.02	0.02	5.3e-03	0.02	0.01	0.02	0.01	1.0e-03	1.2e-02	1.4e-03	2.3e-03
2	Brain	gene expression	Pan2	0.04	0.03	2.1e-03	0.02	0.02	0.01	0.02	8.5e-03	7.8e-03	1.3e-02	1.0e-02
3	Adipose	mRNA stability	Pan2	0.04	0.03	5.6e-04	0.02	0.02	0.02	0.02	4.8e-03	1.7e-03	2.2e-03	3.4e-03
4	IC	gene expression	Pan2	0.08	0.06	4.4e-03	0.04	0.04	0.02	0.03	7.5e-03	7.7e-03	4.5e-02	1.8e-02
5	PL	intron excision ratio	chr7_1326269_1326577	0.04	0.03	6.0e-03	0	0.02	0.01	0.01	1.9e-01	6.5e-03	1.0e-02	2.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.9	1.5	5.8	-1.2	-0.1	0.1	0.6	2.4
Area under the delay curve	0.1	0.1	0.5	-0.7	-0.1	0.1	-0.2	0.1
BMI with tail	7.3	25.1	31.5	-5.6	-5.6	5.6	-5.2	2.0
BMI without tail	2.0	6.2	8.2	-2.9	-2.7	2.7	-2.8	0.8
Body weight	1.1	4.9	6.8	-2.5	-2.4	2.4	-2.6	0.1
Weight adjusted by age	0.1	0.1	0.2	0.3	0.2	-0.2	0.2	-0.4
Bone surface	1.6	2.9	11.1	-0.7	0.6	-0.5	1.6	3.3
Bone volume	1.7	3.1	12.2	-1.1	0.3	-0.2	1.3	3.5
Breakpoint value in progressive ratio session	1.0	1.2	2.3	1.5	1.1	-1.1	1.0	-0.5
Number of licking bursts	1.9	3.1	4.1	-1.9	-2.0	2.0	-2.0	-0.2
Context. condit. distance diff. score	0.2	0.2	0.3	-0.4	-0.6	0.6	-0.5	0.1
Locomotion velocity, session 1	0.5	0.6	2.0	-0.9	-0.2	0.2	0.2	1.4
Locomotion distance, session 1	0.6	0.7	2.2	-0.1	0.5	-0.5	0.9	1.5
Locomotion velocity, session 2	1.6	1.8	3.4	0.8	1.3	-1.3	1.8	1.3
Locomotion distance, session 2	2.5	3.4	6.4	1.1	2.1	-2.1	2.5	0.8
Locomotion velocity, session 3	4.4	5.0	6.1	2.5	2.5	-2.5	2.3	-1.2
Locomotion distance, session 3	0.1	0.1	0.2	0.4	0.3	-0.3	0.2	-0.4
Stereotopy head waving bouts, day 3	4.9	5.8	7.5	2.6	2.7	-2.7	2.7	-0.5
Stereotopy head waving duration, day 3	3.5	4.2	5.5	2.3	2.2	-2.2	2.3	-0.4
Locomotion velocity, session 7	0.1	0.1	0.2	0.3	0.3	-0.2	0.5	0.4
Locomotion distance, session 7	0.2	0.2	0.5	-0.0	-0.3	0.3	-0.5	-0.7
Stereotopy head waving bouts, day 7	0.9	1.0	1.8	0.5	1.1	-1.0	1.3	0.7
Stereotopy head waving duration, day 7	0.8	1.0	1.7	0.3	1.0	-1.0	1.3	1.0
Locomotion velocity, session 8	1.3	1.5	2.9	0.3	1.3	-1.3	1.7	1.1
Locomotion distance, session 8	0.3	0.4	0.8	0.4	0.8	-0.8	0.9	0.2
Degree of sensitization distance	0.6	0.6	0.8	-0.9	-0.9	0.9	-0.7	0.4
Degree of sensitization stereotypy	0.3	0.3	0.9	-0.6	-0.2	0.2	0.1	1.0
Conditioned locomotion	1.0	1.2	2.2	-0.6	-1.0	1.0	-1.5	-1.0
Cocaine response after cond. corrected	1.8	2.2	3.1	-1.2	-1.7	1.7	-1.7	-0.6
Cocaine response after cond. not corrected	2.0	2.3	3.8	-1.1	-1.8	1.8	-1.9	-0.7
Cocaine response before conditioning	0.4	0.5	0.7	0.8	0.8	-0.8	0.6	-0.0
Saline control response	0.6	0.7	1.4	-0.9	-0.9	0.8	-1.2	-0.4
Bone: connectivity density	0.5	0.8	3.0	-0.8	-0.0	0.1	0.5	1.7
Bone: cortical apparent density	1.0	1.4	1.9	-1.2	-1.4	1.4	-1.1	0.8
Bone: cortical area	1.2	1.8	4.8	-1.4	-1.0	1.0	-0.3	2.2
Bone: cortical porosity	0.1	0.1	0.6	-0.0	-0.0	0.1	0.1	0.8
Bone: cortical porosity	0.4	0.4	1.8	-0.4	-0.3	0.3	-0.0	1.3
Bone: cortical thickness	1.6	2.6	3.5	-1.7	-1.6	1.6	-1.1	1.9
Bone: cortical thickness	0.7	0.8	1.2	-0.8	-1.0	1.0	-1.1	-0.1
Bone: cortical tissue density	0.7	1.0	1.3	-1.0	-1.1	1.1	-0.9	0.7
Condit. Reinf. active minus inactive responses	1.9	2.1	3.0	1.6	1.5	-1.5	1.7	-0.4
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.8	0.9	0.4	-0.4	0.5	-0.6
Condit. Reinf. active responses	2.7	3.4	5.9	1.8	2.0	-2.0	2.4	0.1
Condit. Reinf. inactive responses	1.5	1.8	3.5	0.9	1.5	-1.5	1.9	0.6
Incentive salience index mean	1.3	1.6	2.9	1.1	1.3	-1.3	1.7	0.4
Condit. Reinf. lever presses	0.6	0.9	1.9	-0.1	0.7	-0.7	1.2	1.4
Condit. Reinf. active minus inactive responses	2.4	3.1	4.8	2.2	1.7	-1.8	1.3	-1.7
Condit. Reinf. active-inactive response ratio	1.3	1.5	4.3	1.4	0.8	-0.8	0.2	-2.1
Condit. Reinf. active responses	1.6	2.2	3.2	1.8	1.6	-1.6	1.4	-0.8
Condit. Reinf. inactive responses	0.3	0.4	0.6	0.5	0.7	-0.7	0.8	0.4
Condit. Reinf. lever presses	2.4	3.3	4.5	2.1	1.9	-1.9	1.5	-1.5
Condit. Reinf. lever reinforcers received	1.2	1.7	2.7	1.7	1.4	-1.4	1.0	-1.0
Conditioned reinforcement - actives	0.0	0.0	0.1	0.2	-0.1	0.1	-0.3	0.2
Conditioned reinforcement - inactives	0.3	0.4	0.9	0.0	-0.7	0.8	-0.9	-0.2
Conditioned locomotion	1.8	2.3	3.9	2.0	1.6	-1.6	1.6	0.2
Patch foraging indifference point 0 sec	3.1	5.7	6.9	-2.5	-2.6	2.6	-2.4	1.8
Patch foraging indifference point AUC	0.7	1.0	1.1	1.0	1.0	-1.0	1.0	-0.8
Delay disc. indifference point, 0s delay	2.3	2.5	5.2	-2.3	-1.1	1.2	-0.8	2.0
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	0.3	0.5	-0.5	0.6	-0.0
Delay disc. indifference point, 2s delay	0.5	0.5	1.3	-1.2	-0.4	0.4	-0.2	0.9
Delay disc. indifference point, 24s delay	0.3	0.4	0.9	-1.0	-0.5	0.5	-0.7	0.1
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	-0.1	0.6	-0.6	0.7	0.7
Delay disc. indifference point, 8s delay	0.2	0.3	0.4	-0.6	-0.3	0.3	-0.6	-0.6
Indifference point function ln k	0.1	0.1	0.2	0.0	-0.4	0.4	-0.5	0.2
Indifference point function log k	0.1	0.1	0.2	0.0	-0.4	0.4	-0.5	0.2
Patch foraging total patch changes 0 sec	2.7	5.1	6.1	-2.3	-2.5	2.5	-2.2	1.7
Patch foraging total patch changes 12 sec	1.7	2.1	2.9	-1.5	-1.7	1.7	-1.7	0.2
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.1	0.3
Patch foraging total patch changes 24 sec	0.4	0.7	1.1	-1.0	-0.7	0.8	-0.6	0.8
Patch foraging total patch changes 6 sec	1.7	2.5	3.3	-1.7	-1.8	1.8	-1.4	1.2
Patch foraging time to switch 0 sec	0.3	0.6	1.5	-1.2	-0.6	0.6	-0.2	1.1
Patch foraging water rate 0 sec	0.3	0.7	1.5	-0.4	-0.9	0.9	-1.2	-0.6
Patch foraging water rate 12 sec	0.5	1.0	2.0	-0.4	-1.1	1.1	-1.4	-0.5
Patch foraging water rate 18 sec	0.8	1.3	4.9	0.9	-0.2	0.1	-0.9	-2.2
Patch foraging water rate 24 sec	1.9	2.7	4.8	-0.4	-1.5	1.5	-2.2	-2.0
Patch foraging water rate 6 sec	0.9	1.3	3.1	1.6	0.6	-0.6	-0.0	-1.8
Seeking ratio, delayed vs. immediate footshock	1.1	1.4	2.0	1.1	1.3	-1.3	1.4	0.3
Distance traveled before self-admin	1.3	1.7	2.1	1.4	1.4	-1.4	1.4	-0.5
Distance traveled after self-admin	0.0	0.0	0.0	-0.2	0.1	-0.1	-0.2	-0.1
Extensor digitorum longus weight	4.6	18.1	23.7	-4.4	-4.9	4.8	-4.9	0.6
Bone: elastic displacement	0.0	0.0	0.1	0.1	-0.1	0.1	-0.2	0.2
Bone: elastic work	0.9	1.2	1.8	-1.3	-1.0	1.0	-0.9	1.2
Bone: endosteal estimation	0.5	1.1	1.8	-1.1	-1.0	1.0	-0.5	1.3
Bone: endosteal perimeter	0.4	0.9	1.8	0.5	0.8	-0.8	1.3	0.9
Epididymis fat weight	0.2	0.5	2.0	0.6	0.3	-0.4	-0.1	-1.4
Delta time in closed arm before/after self-admin	1.7	1.6	3.0	-0.2	-1.3	1.2	-1.7	-1.4
Delta time in open arm before/after self-admin	0.9	0.9	1.9	-1.4	-0.9	0.9	-1.1	0.2
Diff in mean of infusions in LGA sessions	1.9	2.3	3.6	1.9	1.6	-1.6	1.4	-0.8
Delay discount exponential model param	0.1	0.1	0.3	0.6	-0.0	0.0	0.0	-0.0
Extinction: sum of active levers before priming	1.7	1.9	3.0	1.7	1.3	-1.3	0.9	-1.5
Active lever presses in extinction session 6	0.2	0.2	0.4	0.4	0.5	-0.5	0.6	0.2
Bone: final force	3.0	4.8	7.3	-2.7	-2.0	2.1	-1.3	2.5
Bone: final moment	2.9	4.7	7.2	-2.7	-2.0	2.1	-1.3	2.5
Food consumed during 24 hour testing period	0.3	0.4	0.7	-0.8	-0.7	0.7	-0.6	0.3
Glucose	1.3	2.1	3.1	-1.8	-1.5	1.5	-1.6	0.5
Heart weight	0.3	0.5	0.9	0.9	0.6	-0.6	0.2	-1.0
Delay discount hyperbolic model param	0.2	0.2	0.9	0.9	0.3	-0.3	0.2	-0.4
Intermittent access intake day 1-15 change	0.5	0.9	2.7	1.7	0.7	-0.7	0.3	-1.0
Intermittent access intake escalation	0.4	0.8	2.4	1.6	0.6	-0.6	0.2	-1.0
Intermittent access intake escalation 2	0.8	0.9	2.3	1.5	0.9	-0.9	0.5	-0.8
Intermitt. access day 1 inactive lever presses	0.3	1.2	3.5	1.3	0.6	-0.6	-0.0	-1.9
Intermitt. access day 15 inactive lever presses	0.5	1.1	1.6	1.3	1.1	-1.1	0.8	-0.9
Intermitt. access escalation Index	0.2	0.3	1.0	-0.5	-0.1	0.2	0.2	1.0
Intermittent access day 1 total infusions	0.2	0.3	0.6	-0.5	-0.5	0.5	-0.8	0.0
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.3	-0.1	0.1	-0.3	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	0.3	0.2	-0.1	0.1	0.7
Intermittent access total infusions	0.1	0.2	0.3	-0.2	-0.4	0.4	-0.5	0.5
Intermittent access day 1 locomotion	0.2	0.3	0.7	0.1	-0.3	0.3	-0.8	-0.7
Intermittent access day 15 total locomotion	0.2	0.4	1.4	1.2	0.4	-0.4	-0.1	-0.6
Intermittent access total locomotion	0.1	0.1	0.3	0.5	0.3	-0.3	-0.2	-0.4
Intermittent access standard deviation	0.5	1.0	2.0	1.4	1.0	-0.9	1.0	0.3
Left kidney weight	0.0	0.1	0.3	-0.1	-0.0	0.0	-0.1	-0.5
Right kidney weight	0.2	0.7	1.3	0.8	0.8	-0.8	0.6	-1.2
Cocaine induced anxiety	1.3	1.8	3.6	0.9	1.5	-1.5	1.9	0.7
Post-drug Anxiety	1.2	1.3	2.4	0.2	1.0	-0.9	1.5	1.6
Baseline Anxiety	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.2	0.2
Tail length	3.1	12.1	15.3	3.8	3.9	-3.9	3.2	-2.2
Length with tail	1.4	6.0	7.6	2.8	2.6	-2.6	2.0	-2.1
Length without tail	0.2	0.6	1.0	-0.6	-0.9	0.9	-1.0	-0.3
Times rat made contact with spout	1.1	1.2	2.0	-1.0	-1.2	1.2	-1.4	-0.3
Lifetime Intake	0.7	0.8	1.0	-0.7	-0.9	1.0	-1.0	1.0
Liver weight, left	0.3	0.6	0.8	-0.9	-0.8	0.8	-0.8	0.1
Liver weight, right	0.1	0.2	0.9	0.2	0.4	-0.4	0.1	-0.9
Locomotor activity	2.6	4.0	5.8	1.9	2.4	-2.4	2.2	-0.1
Locomotor testing distance	1.1	2.1	3.0	1.3	1.7	-1.7	1.7	0.1
Locomotor testing rearing	0.0	0.1	0.3	0.2	0.1	-0.1	-0.2	-0.5
Locomotion in novel chamber	0.1	0.1	0.1	-0.1	-0.3	0.3	-0.2	0.3
Locomotion in novel chamber post-restriction	3.2	5.3	6.8	2.4	2.6	-2.6	2.4	-1.1
Fecal boli incidents, locomotor time 1	0.6	0.9	1.6	-0.8	-1.0	0.9	-1.3	-0.6
Change in fecal boli incidents, locomotor task	0.7	0.7	1.2	0.4	0.8	-0.8	1.1	1.0
Time >=10cm from walls, locomotor time 1	0.8	0.8	2.1	-1.1	-0.6	0.7	-0.3	1.5
Bouts of movement, locomotor time 1	0.6	0.7	1.0	1.0	0.9	-0.9	0.6	-0.7
Total resting periods, locomotor time 1	1.3	1.4	1.8	1.3	1.3	-1.4	1.1	-0.7
Rest time, locomotor task time 1	0.4	0.5	0.8	0.5	0.9	-0.9	0.8	0.1
Distance moved, locomotor task time 1	0.8	1.2	2.9	-1.1	-0.9	0.9	-0.3	1.7
Vertical activity count, locomotor time 1	0.5	1.1	1.8	-0.9	-1.3	1.3	-1.0	0.5
Time >=10cm from walls, locomotor time 2	0.7	1.0	1.4	-0.9	-1.2	1.2	-1.2	-0.1
Bouts of movement, locomotor time 2	0.2	0.3	0.6	0.1	0.5	-0.5	0.6	0.8
Total resting periods, locomotor time 2	0.2	0.4	1.0	-0.0	0.5	-0.4	0.6	1.0
Rest time, locomotor task time 2	0.2	0.2	0.6	-0.2	0.3	-0.3	0.5	0.8
Distance moved, locomotor task time 2	0.1	0.2	0.5	0.3	-0.2	0.2	-0.4	-0.7
Vertical activity count, locomotor time 2	0.8	1.2	1.8	-0.6	-1.3	1.2	-1.4	-0.7
Light reinforcement 1	2.4	5.9	8.0	2.8	2.7	-2.7	2.5	-0.4
Light reinforcement 2	0.8	1.2	1.8	1.3	1.3	-1.3	1.0	-0.3
Bone: marrow area	0.4	0.9	1.6	-1.0	-0.9	1.0	-0.5	1.3
Bone: maximum diameter	0.6	1.2	2.4	0.5	0.9	-0.9	1.6	1.3
Bone: maximum force	2.7	4.9	7.4	-2.7	-2.1	2.2	-1.5	2.3
Bone: maximum moment	2.8	4.9	7.4	-2.7	-2.1	2.2	-1.5	2.3
Mean time between licks in bursts	0.5	1.1	2.2	1.5	1.0	-1.0	1.0	-0.6
Mean num. licks in bursts	0.4	0.6	0.8	0.9	0.9	-0.9	0.7	-0.0
Cd content in liver	0.3	0.4	0.7	0.9	0.5	-0.5	0.8	0.0
Co content in liver	2.7	3.1	4.3	2.1	1.8	-1.9	1.6	-1.3
Cu content in liver	0.6	0.7	2.7	-0.5	-0.5	0.6	0.1	1.6
Fe content in liver	0.2	0.2	0.3	-0.1	-0.5	0.5	-0.6	-0.1
K content in liver	0.7	0.7	1.2	0.6	0.9	-0.9	1.1	0.5
Mg content in liver	1.1	1.1	2.1	0.8	1.2	-1.2	1.5	0.0
Mn content in liver	2.1	2.3	4.3	0.6	1.4	-1.3	2.1	1.7
Na content in liver	0.2	0.2	0.8	-0.6	-0.2	0.2	-0.2	0.9
Rb content in liver	0.5	0.6	2.4	-0.5	-0.3	0.4	0.4	1.6
Se content in liver	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	-0.0
Sr content in liver	0.3	0.3	0.7	0.8	0.3	-0.3	0.1	-0.7
Zn content in liver	3.5	3.9	6.0	2.3	1.7	-1.8	1.3	-2.4
Bone: minimum diameter	0.4	0.7	2.4	-0.8	-0.5	0.5	0.1	1.6
Time in familiar zone, hab. session 1	4.5	4.4	5.3	2.3	2.3	-2.3	1.9	-1.6
Time in novel zone, hab. session 1	3.6	3.6	4.8	-2.2	-1.8	1.9	-1.3	2.1
Total zone transitions, hab. session 1	0.5	0.8	1.2	0.0	0.8	-0.8	1.1	1.1
Total locomotion distance, hab. session 1	1.8	2.6	4.7	0.7	1.7	-1.6	2.2	1.5
Locomotion velocity, hab. session 1	1.8	2.5	4.3	1.0	1.8	-1.7	2.1	1.0
Time in familiar zone, hab. session 2	5.0	5.2	7.7	2.8	2.3	-2.4	1.8	-2.0
Time in novel zone, hab. session 2	5.5	5.6	8.1	-2.8	-2.4	2.4	-1.8	2.3
Total zone transitions, hab. session 2	1.2	1.5	4.9	-1.3	-0.6	0.7	-0.1	2.2
Total locomotion distance, hab. session 2	0.4	0.6	0.9	0.1	0.7	-0.7	0.9	0.9
Locomotion velocity, hab. session 2	0.6	0.8	1.5	0.0	0.8	-0.8	1.1	1.2
Novel to familiar place preference ratio	3.1	3.4	4.7	-2.2	-1.7	1.7	-1.3	2.2
Novelty place preference	2.1	2.2	3.7	-1.7	-1.3	1.4	-0.9	1.9
Time in novel zone, NPP test	2.6	2.8	3.9	-1.9	-1.6	1.6	-1.2	2.0
Total zone transitions, NPP test	0.6	0.8	1.6	-1.3	-0.6	0.6	-0.4	1.3
Total locomotion distance, NPP test	0.3	0.5	1.7	-0.7	-0.0	0.1	0.2	1.3
Locomotion velocity, NPP test	0.2	0.4	1.1	-0.4	0.3	-0.3	0.5	1.1
Intraocular pressure	0.6	0.9	3.3	0.7	0.5	-0.5	-0.1	-1.8
Delta distance traveled before/after self-admin	0.7	0.8	1.2	-1.1	-0.9	0.9	-1.1	0.1
Delta ambulatory time before/after self-admin	0.7	0.8	1.6	-1.3	-0.8	0.9	-0.9	0.6
Parametrial fat weight	0.4	1.0	1.5	-1.2	-1.0	1.0	-0.9	0.8
Pavlov. Cond. lever latency	0.4	0.5	1.8	0.3	-0.3	0.3	-0.8	-1.3
Pavlov. Cond. magazine entry latency	1.4	1.8	2.2	1.5	1.5	-1.5	1.5	-0.6
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.1	0.4
Pavlov. Cond. index score	0.5	0.6	1.2	0.5	0.8	-0.8	1.1	0.4
Pavlov. Cond. latency score	0.6	0.7	1.5	0.4	0.9	-0.9	1.2	0.7
Pavlov. Cond. lever contacts	0.4	0.5	1.7	-0.5	0.1	-0.1	0.6	1.3
Pavlov. Cond. magazine entry number	0.7	0.8	1.0	-1.0	-1.0	1.0	-1.0	0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.1	0.6	0.1	-0.2	-0.1	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.3	0.6	0.9	-0.9	1.1	0.3
Pavlov. Cond. response bias	0.5	0.6	0.9	0.8	0.9	-0.9	0.9	-0.4
Pavlov. Cond. lever latency	1.4	1.8	2.6	-1.3	-1.6	1.6	-1.3	0.7
Pavlov. Cond. magazine entry latency	2.0	2.4	3.3	1.4	1.8	-1.8	1.7	-0.7
Pavlov. Cond. change in total contacts	0.6	1.0	1.3	1.1	1.1	-1.1	0.8	-0.7
Pavlov. Cond. index score	1.7	2.3	3.0	1.6	1.7	-1.7	1.5	-0.9
Pavlov. Cond. latency score	1.9	2.5	3.4	1.5	1.8	-1.8	1.6	-0.7
Pavlov. Cond. lever contacts	1.3	1.8	2.4	1.4	1.5	-1.5	1.2	-1.0
Pavlov. Cond. magazine entry number	2.1	2.5	3.4	-1.5	-1.9	1.8	-1.8	0.6
Pavlov. Cond. intertrial magazine entries	0.9	1.3	2.3	-0.9	-1.3	1.3	-1.5	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.6	3.4	1.7	1.8	-1.8	1.7	-0.7
Pavlov. Cond. response bias	2.1	2.9	3.6	1.8	1.9	-1.9	1.6	-1.3
Time in closed arm before self-admin	0.3	0.4	1.4	-0.6	-0.2	0.2	0.2	1.2
Time in closed arm after self-admin	0.3	0.4	0.7	-0.2	-0.8	0.8	-0.7	0.3
Time in open arm before self-admin	0.1	0.1	0.3	0.5	-0.0	0.0	0.1	-0.0
Time in open arm after self-admin	1.6	1.8	2.8	-1.6	-1.4	1.4	-1.7	-0.0
Bone: periosteal estimation	1.0	2.2	5.6	-1.6	-1.2	1.2	-0.3	2.4
Bone: periosteal perimeter	0.4	0.7	2.9	-0.3	0.1	-0.1	0.8	1.7
Bone: post-yield work	0.5	0.7	1.0	-1.0	-0.9	0.9	-0.7	0.5
Progressive ratio test 1 active lever presses	0.5	0.6	1.0	-0.7	-0.8	0.8	-1.0	0.2
Progressive ratio test 1 breakpoint	0.5	0.6	1.1	-0.7	-0.8	0.8	-1.0	0.2
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.6	0.8	0.4	-0.4	0.3	-0.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.3	0.2	-0.2	-0.0	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.4	0.3	-0.3	0.1	0.0
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.8	-0.3	-0.3	0.3	-0.4	0.9
Incentive Sensitization - Responses	0.3	0.4	0.7	0.8	0.7	-0.7	0.5	-0.5
Incentive Sensitization - Breakpoint	0.4	0.5	0.8	0.9	0.8	-0.8	0.7	-0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.6	0.4	-0.4	0.3	-0.4
Progressive ratio	0.9	1.5	2.5	-0.9	-1.4	1.4	-1.6	0.1
Food seeking constrained by brief footshock	1.7	2.1	2.8	1.3	1.7	-1.7	1.5	-1.1
Seeking ratio, punishment vs. effort	2.2	3.2	4.3	1.5	2.1	-2.1	2.0	-0.9
Retroperitoneal fat weight	1.9	8.2	12.5	-2.6	-3.3	3.3	-3.5	-0.1
Reaction time number correct	0.7	1.3	2.5	-0.8	-1.2	1.2	-1.6	-0.6
Reaction time mean minus median	0.6	1.6	2.5	1.3	1.4	-1.4	1.6	-0.4
Reaction time mean minus median AUC	0.8	2.0	4.0	0.8	1.5	-1.5	2.0	0.9
Reaction time num false alarms	0.6	0.9	1.4	-1.0	-1.0	1.0	-1.2	0.1
Reaction time num false alarms AUC	0.6	0.9	1.6	-0.9	-1.1	1.0	-1.3	-0.1
Reaction time trials correct on left	0.7	1.3	2.5	-0.8	-1.2	1.2	-1.6	-0.6
Reaction time trials on left	0.6	1.2	2.3	-0.8	-1.2	1.2	-1.5	-0.6
Reaction time mean	1.0	1.6	3.0	0.9	1.4	-1.4	1.7	0.5
Reaction time mean AUC	0.5	0.8	1.7	0.5	0.9	-0.9	1.3	0.7
Median of all reaction times	0.7	0.9	1.8	0.6	1.0	-1.0	1.4	0.6
Reaction time omissions	0.1	0.2	0.8	0.0	0.1	-0.0	0.5	0.9
Reaction time false alarm rate	0.2	0.2	0.4	-0.7	-0.4	0.4	-0.4	0.4
Reaction time premature initiation rate	1.4	1.9	2.7	1.7	1.3	-1.3	0.9	-1.6
Reaction time premature initiations	0.7	1.3	4.0	1.3	0.6	-0.7	-0.0	-2.0
Std. dev. reaction times	0.5	1.0	2.1	0.7	1.1	-1.1	1.5	0.3
Reaction time trials completed	0.6	1.2	2.3	-0.8	-1.2	1.2	-1.5	-0.6
Reaction time trials AUC	0.8	1.5	2.9	-0.8	-1.3	1.3	-1.7	-0.8
Run reversals in cocaine runway, females	2.4	2.4	4.0	1.3	1.8	-1.8	2.0	0.1
Run reversals in cocaine runway, males	2.3	2.3	3.7	1.4	1.7	-1.7	1.9	0.3
Latency to leave start box in cocaine runway	0.6	0.6	2.1	-1.0	-0.2	0.2	0.3	1.4
Latency to leave start box in cocaine runway, F	0.9	1.1	3.7	-1.1	-0.2	0.2	0.5	1.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.0	-0.1	0.1	-0.3	-0.5
Std. dev. time between licks in bursts	0.6	0.9	1.3	0.8	1.0	-0.9	1.1	0.8
Total sessions with >9 infusions	0.5	0.7	1.1	-0.3	-0.8	0.8	-0.9	1.0
Short access day 1 total inactive lever presses	0.4	0.5	1.0	1.0	0.6	-0.6	0.3	-0.9
Short access day 10 total inactive lever presses	0.3	0.8	2.8	1.0	0.2	-0.2	-0.4	-1.7
Short access day 1 total infusions	0.5	0.6	1.0	-0.1	-0.8	0.9	-0.8	1.0
Short access day 10 total infusions	0.2	0.3	0.5	-0.3	-0.5	0.6	-0.7	0.3
Short access total infusions	0.8	1.1	1.4	-0.6	-1.1	1.1	-1.1	1.2
Short access day 1 locomotion	0.3	0.4	1.3	1.1	0.5	-0.5	0.2	-0.4
Short access day 10 total locomotion	1.5	2.9	6.8	2.6	1.3	-1.3	0.6	-1.9
Short access total locomotion	0.3	0.4	1.3	1.1	0.5	-0.4	-0.0	-0.6
One hour access (0.3 mA shock)	0.1	0.2	0.3	-0.3	-0.4	0.4	-0.6	-0.2
Compulsive drug intake	0.0	0.0	0.1	-0.1	0.2	-0.2	0.3	0.2
One hour access (shock baseline)	0.0	0.1	0.2	0.5	0.1	-0.1	-0.1	-0.3
Social response proportion	0.7	0.8	1.3	0.7	1.1	-1.1	0.9	-0.1
Social responses	7.6	9.8	13.7	3.0	3.7	-3.7	3.5	-0.7
Social time	0.9	1.3	1.8	-1.1	-1.3	1.3	-1.4	-0.0
Soleus weight	5.4	16.0	19.9	-4.5	-4.5	4.5	-4.1	1.8
Bone: stiffness	3.7	6.0	8.4	-2.9	-2.5	2.6	-1.9	2.2
Tibialis anterior weight	1.2	4.1	5.5	-2.3	-2.3	2.3	-2.0	0.9
Time to tail flick, vehicle, before self-admin	1.2	1.2	2.2	1.0	1.1	-1.1	1.5	0.5
Time to tail flick, vehicle, after self-admin	0.6	0.8	2.6	1.0	0.5	-0.6	0.2	-1.6
Time to tail flick, test, before self-admin	0.8	0.8	1.6	0.4	0.8	-0.8	1.3	0.9
Time to tail flick, test, after self-admin	0.1	0.1	0.4	-0.1	-0.0	0.0	0.1	0.6
Delta time to tail flick, vehicle, before/after SA	1.4	1.3	2.2	-0.8	-1.1	1.1	-1.5	-1.2
Delta time to tail flick, test, before/after SA	0.4	0.4	1.4	0.3	-0.2	0.1	-0.7	-1.2
Tibia length	0.8	2.3	2.9	1.5	1.7	-1.7	1.4	-1.3
Ambulatory time before self-admin	0.3	0.5	0.8	0.9	0.8	-0.8	0.7	-0.3
Ambulatory time after self-admin	0.0	0.0	0.1	-0.2	-0.0	0.0	-0.2	0.1
Bone: tissue strength	5.0	5.1	6.0	-2.4	-2.4	2.4	-2.1	1.7
Total heroin consumption	1.9	2.2	3.1	1.5	1.8	-1.7	1.7	-0.3
Bone: trabecular number	0.5	0.9	1.6	-0.2	0.8	-0.8	1.3	1.2
Bone: trabecular spacing	1.0	1.3	4.3	0.7	-0.6	0.5	-1.1	-2.1
Bone: trabecular thickness	2.2	2.7	10.9	-1.4	-0.0	0.1	0.9	3.3
Bone: trabecular tissue density	4.1	6.0	8.2	-2.4	-2.8	2.8	-2.9	0.4
Water consumed over 24 hours	0.8	1.0	1.6	-1.2	-0.9	0.9	-0.6	1.2
Number of responses in last shaping day	2.1	2.3	5.4	2.3	1.4	-1.4	1.0	-1.1