Hub : Genes

Pamr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Pamr1 0.06 0.05 1.8e-06 0.05 0.05 0.04 0.05 7.4e-06 4.5e-06 1.5e-05 7.6e-06
2 OFC gene expression Pamr1 0.24 0.14 1.9e-05 0.11 0.17 0.1 0.14 1.3e-03 7.2e-05 2.1e-03 4.5e-04
3 LHb gene expression Pamr1 0.34 0.18 4.0e-08 0.25 0.25 0.25 0.25 1.4e-06 1.0e-06 1.2e-06 1.2e-06
4 PL gene expression Pamr1 0.28 0.06 0.0e+00 0.39 0.39 0.39 0.39 1.1e-44 9.3e-46 2.6e-45 2.6e-45
5 RMTg gene expression Pamr1 0.39 0.11 6.1e-12 0.24 0.32 0.33 0.36 4.7e-07 4.1e-09 1.7e-09 2.8e-10
6 pVTA gene expression Pamr1 0.5 0.06 0.0e+00 0.59 0.2 0.61 0.2 3.0e-58 2.9e-16 2.0e-61 1.3e-15
7 Brain gene expression Pamr1 0.2 0.02 0.0e+00 0.56 0.17 0.56 0.21 5.8e-62 5.0e-16 2.7e-63 1.5e-19
8 IC gene expression Pamr1 0.5 0.15 1.3e-14 0.28 0.32 0.29 0.26 4.6e-12 3.4e-14 1.3e-12 3.3e-11
9 BLA gene expression Pamr1 0.55 0.19 0.0e+00 0.44 0.45 0.45 0.45 3.8e-25 3.1e-26 5.8e-26 2.0e-26
10 IL gene expression Pamr1 0.61 0.19 1.8e-05 0.17 0.18 0.17 0.19 7.5e-05 4.3e-05 8.4e-05 2.5e-05
11 NAcc gene expression Pamr1 0.31 0.07 0.0e+00 0.36 0.1 0.35 0.1 3.1e-56 1.8e-14 1.9e-55 2.6e-14
12 Liver gene expression Pamr1 0.25 0.2 5.3e-11 0.08 0.08 0.08 0.08 1.9e-09 1.8e-09 2.7e-09 1.9e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.01.71.9-1.31.31.31.41.31.31.31.31.31.21.21.3
Area under the delay curve0.40.40.50.6-0.6-0.6-0.7-0.7-0.7-0.7-0.7-0.6-0.6-0.6-0.7
BMI with tail0.20.71.20.5-0.5-0.5-0.9-0.5-0.8-0.7-0.8-1.0-1.1-1.1-1.1
BMI without tail0.10.30.90.0-0.1-0.1-0.6-0.3-0.6-0.5-0.6-0.7-0.8-0.8-0.9
Body weight0.10.20.7-0.30.20.2-0.4-0.1-0.4-0.3-0.4-0.6-0.7-0.7-0.8
Weight adjusted by age1.42.12.71.6-1.6-1.6-1.5-1.6-1.5-1.6-1.4-1.3-1.2-1.2-1.3
Bone surface0.20.40.6-0.70.70.70.60.60.60.80.50.50.40.40.4
Bone volume1.42.63.0-1.71.71.71.71.61.61.61.61.61.51.51.4
Breakpoint value in progressive ratio session0.30.40.90.9-0.9-0.8-0.4-0.5-0.3-0.3-0.4-0.5-0.6-0.6-0.0
Number of licking bursts0.00.00.1-0.20.20.10.20.10.2-0.10.10.30.30.30.0
Context. condit. distance diff. score5.36.48.3-2.02.02.12.72.32.62.92.52.72.82.82.9
Locomotion velocity, session 10.00.00.0-0.0-0.00.00.0-0.10.00.10.0-0.2-0.2-0.20.0
Locomotion distance, session 10.30.30.4-0.40.50.50.60.50.60.50.60.70.70.70.6
Locomotion velocity, session 20.00.00.00.2-0.2-0.2-0.2-0.2-0.1-0.2-0.2-0.1-0.1-0.1-0.2
Locomotion distance, session 20.20.20.4-0.60.60.50.40.50.40.20.40.50.50.50.1
Locomotion velocity, session 30.20.20.5-0.50.50.50.50.50.40.70.50.40.50.50.5
Locomotion distance, session 30.20.20.3-0.50.50.50.30.50.30.50.30.40.40.40.2
Stereotopy head waving bouts, day 30.50.61.0-0.50.50.60.80.60.80.90.80.90.80.81.0
Stereotopy head waving duration, day 30.91.01.3-0.80.90.91.10.91.01.11.11.11.01.01.1
Locomotion velocity, session 71.11.21.5-0.90.90.91.11.11.11.11.11.21.21.21.2
Locomotion distance, session 70.00.10.10.2-0.2-0.10.10.10.20.10.10.30.40.40.3
Stereotopy head waving bouts, day 70.10.10.4-0.10.10.20.50.20.40.60.40.30.20.20.6
Stereotopy head waving duration, day 70.00.00.10.0-0.1-0.0-0.0-0.1-0.10.1-0.1-0.3-0.3-0.3-0.0
Locomotion velocity, session 81.72.12.7-1.21.21.21.51.31.41.71.41.51.61.61.5
Locomotion distance, session 84.46.47.7-2.32.22.32.72.42.62.72.52.72.82.82.5
Degree of sensitization distance0.10.10.10.4-0.4-0.30.1-0.10.1-0.00.10.20.20.20.4
Degree of sensitization stereotypy0.00.00.10.1-0.2-0.10.0-0.1-0.00.3-0.1-0.2-0.3-0.30.1
Conditioned locomotion4.04.65.62.3-2.4-2.4-2.1-2.3-2.2-2.3-2.2-1.9-1.8-1.8-2.1
Cocaine response after cond. corrected2.63.13.41.7-1.7-1.7-1.8-1.7-1.8-1.8-1.7-1.8-1.8-1.8-1.7
Cocaine response after cond. not corrected1.11.31.61.1-1.1-1.1-1.2-1.1-1.1-1.3-1.1-1.2-1.2-1.2-1.1
Cocaine response before conditioning3.84.65.0-2.12.12.12.22.12.12.22.12.22.22.22.0
Saline control response0.30.40.7-0.80.80.80.60.80.70.70.70.50.30.30.6
Bone: connectivity density0.50.70.9-0.90.90.90.90.80.90.90.80.80.80.80.8
Bone: cortical apparent density0.00.00.10.1-0.1-0.1-0.0-0.2-0.1-0.3-0.1-0.0-0.1-0.1-0.1
Bone: cortical area0.20.20.80.1-0.1-0.2-0.5-0.3-0.5-0.4-0.6-0.6-0.6-0.6-0.9
Bone: cortical porosity0.00.00.10.3-0.3-0.2-0.2-0.3-0.2-0.1-0.1-0.2-0.2-0.2-0.1
Bone: cortical porosity0.30.30.40.6-0.6-0.6-0.5-0.6-0.5-0.3-0.5-0.6-0.6-0.6-0.4
Bone: cortical thickness0.50.81.60.4-0.5-0.5-1.0-0.6-0.9-1.0-0.9-1.0-1.0-1.0-1.3
Bone: cortical thickness5.86.88.72.5-2.6-2.6-2.6-2.7-2.6-2.9-2.7-2.5-2.4-2.4-2.7
Bone: cortical tissue density0.00.00.10.1-0.1-0.10.0-0.2-0.1-0.3-0.10.0-0.0-0.0-0.1
Condit. Reinf. active minus inactive responses1.01.11.2-1.11.11.01.11.01.10.91.01.11.11.11.0
Condit. Reinf. active-inactive response ratio0.70.71.3-1.11.11.10.90.90.80.70.80.70.70.70.6
Condit. Reinf. active responses0.20.20.3-0.50.50.50.50.40.50.30.50.50.60.60.3
Condit. Reinf. inactive responses0.20.30.40.6-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.5-0.4-0.4-0.6
Incentive salience index mean0.50.60.8-0.90.90.90.80.80.80.60.70.80.70.70.6
Condit. Reinf. lever presses0.10.10.3-0.60.50.50.20.40.20.20.20.10.10.1-0.1
Condit. Reinf. active minus inactive responses2.02.63.6-1.31.31.31.71.41.71.31.71.91.91.91.8
Condit. Reinf. active-inactive response ratio3.64.25.1-1.91.91.92.11.92.11.72.12.32.22.22.1
Condit. Reinf. active responses0.81.21.6-0.91.00.91.11.01.10.81.11.31.31.31.1
Condit. Reinf. inactive responses0.20.20.30.4-0.4-0.5-0.5-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.5
Condit. Reinf. lever presses0.81.11.2-1.01.01.01.11.11.11.01.11.11.11.11.1
Condit. Reinf. lever reinforcers received1.11.62.0-1.11.11.11.31.11.31.01.31.41.41.41.3
Conditioned reinforcement - actives2.13.64.6-2.12.12.12.01.91.91.91.91.81.51.51.7
Conditioned reinforcement - inactives3.04.47.8-2.82.82.72.02.41.92.12.11.71.41.41.4
Conditioned locomotion0.81.11.6-1.31.31.21.11.21.10.91.00.90.70.70.8
Patch foraging indifference point 0 sec0.00.00.00.2-0.2-0.20.0-0.10.0-0.00.00.10.20.20.2
Patch foraging indifference point AUC0.50.71.01.0-1.0-0.9-1.0-0.7-0.9-0.8-0.8-0.8-0.8-0.8-0.7
Delay disc. indifference point, 0s delay0.30.30.70.4-0.4-0.4-0.7-0.5-0.7-0.7-0.6-0.5-0.5-0.5-0.8
Delay disc. indifference point, 16s delay3.23.54.21.7-1.7-1.8-2.0-1.7-1.9-1.9-1.9-2.0-2.0-2.0-1.9
Delay disc. indifference point, 2s delay0.30.30.60.7-0.7-0.7-0.6-0.7-0.5-0.8-0.5-0.3-0.3-0.3-0.4
Delay disc. indifference point, 24s delay0.00.00.20.3-0.3-0.30.1-0.00.10.10.1-0.0-0.1-0.10.4
Delay disc. indifference point, 4s delay0.70.81.00.9-0.8-0.9-0.9-1.0-0.9-0.9-0.9-0.8-0.8-0.8-1.0
Delay disc. indifference point, 8s delay0.20.30.4-0.40.40.40.50.50.60.60.50.60.60.60.5
Indifference point function ln k0.00.00.2-0.40.40.30.20.20.1-0.0-0.00.0-0.0-0.0-0.3
Indifference point function log k0.00.00.2-0.40.40.30.20.20.1-0.0-0.00.0-0.0-0.0-0.3
Patch foraging total patch changes 0 sec0.00.10.20.00.00.00.20.10.20.10.20.40.40.40.4
Patch foraging total patch changes 12 sec0.30.30.7-0.60.60.70.50.70.60.80.60.40.40.40.6
Patch foraging total patch changes 18 sec0.00.10.20.5-0.4-0.4-0.1-0.2-0.0-0.4-0.00.20.20.20.2
Patch foraging total patch changes 24 sec0.20.30.80.9-0.9-0.7-0.5-0.5-0.4-0.2-0.4-0.5-0.5-0.5-0.0
Patch foraging total patch changes 6 sec0.00.00.10.10.00.00.10.20.20.00.30.20.10.10.4
Patch foraging time to switch 0 sec0.40.71.2-0.60.60.70.90.70.90.81.01.00.90.91.1
Patch foraging water rate 0 sec0.30.61.10.6-0.6-0.6-0.8-0.7-0.9-0.7-0.9-0.9-0.8-0.8-1.0
Patch foraging water rate 12 sec0.51.01.11.0-1.1-1.1-0.9-1.0-0.9-1.0-1.0-0.9-1.0-1.0-0.9
Patch foraging water rate 18 sec0.10.20.3-0.60.60.60.50.50.50.40.40.40.40.40.4
Patch foraging water rate 24 sec1.21.72.21.1-1.2-1.2-1.3-1.3-1.4-1.2-1.4-1.4-1.3-1.3-1.5
Patch foraging water rate 6 sec0.30.50.60.7-0.7-0.7-0.7-0.6-0.7-0.6-0.8-0.7-0.7-0.7-0.7
Seeking ratio, delayed vs. immediate footshock0.50.61.70.1-0.1-0.2-0.9-0.4-0.9-1.2-0.8-0.8-0.8-0.8-1.3
Distance traveled before self-admin0.10.10.30.1-0.1-0.2-0.4-0.3-0.4-0.4-0.4-0.4-0.3-0.3-0.6
Distance traveled after self-admin0.20.20.40.2-0.3-0.3-0.5-0.4-0.5-0.6-0.5-0.4-0.3-0.3-0.6
Extensor digitorum longus weight0.41.61.81.2-1.2-1.2-1.3-1.2-1.3-1.1-1.3-1.3-1.3-1.3-1.3
Bone: elastic displacement1.31.51.81.3-1.3-1.3-1.3-1.2-1.2-1.0-1.1-1.3-1.3-1.3-1.0
Bone: elastic work1.62.12.41.4-1.4-1.4-1.6-1.3-1.4-1.4-1.4-1.5-1.5-1.5-1.4
Bone: endosteal estimation0.30.81.00.8-0.9-0.9-0.8-1.0-0.9-0.7-0.9-0.9-0.8-0.8-0.9
Bone: endosteal perimeter0.10.30.4-0.60.50.50.60.40.50.60.40.50.60.60.4
Epididymis fat weight0.72.43.1-1.71.71.71.51.81.61.71.51.41.31.31.3
Delta time in closed arm before/after self-admin0.30.30.60.00.00.10.60.20.50.50.40.80.70.70.8
Delta time in open arm before/after self-admin0.40.41.20.1-0.1-0.2-0.7-0.5-0.8-0.7-0.7-0.8-0.6-0.6-1.1
Diff in mean of infusions in LGA sessions3.03.64.51.6-1.6-1.7-1.9-1.8-1.9-1.9-1.9-2.1-2.1-2.1-2.1
Delay discount exponential model param0.30.40.5-0.60.60.60.60.70.60.70.60.60.50.50.6
Extinction: sum of active levers before priming0.10.10.3-0.00.00.10.40.20.40.60.30.2-0.1-0.10.6
Active lever presses in extinction session 63.33.35.9-1.11.11.22.01.62.02.11.91.91.81.82.4
Bone: final force0.00.10.3-0.0-0.0-0.0-0.3-0.1-0.2-0.3-0.3-0.3-0.3-0.3-0.5
Bone: final moment0.10.10.30.1-0.2-0.2-0.4-0.3-0.4-0.3-0.4-0.4-0.4-0.4-0.6
Food consumed during 24 hour testing period3.24.46.5-2.62.52.52.02.32.02.12.01.81.71.71.6
Glucose2.74.24.6-2.02.12.02.02.12.01.92.02.12.12.11.9
Heart weight0.20.40.90.9-0.9-0.9-0.5-0.6-0.4-0.9-0.5-0.2-0.1-0.1-0.2
Delay discount hyperbolic model param0.40.40.5-0.70.70.70.70.70.60.70.70.60.60.60.7
Intermittent access intake day 1-15 change0.51.11.4-0.90.80.91.11.01.21.11.01.21.01.01.2
Intermittent access intake escalation0.81.72.1-1.11.01.11.41.21.41.31.31.41.31.31.4
Intermittent access intake escalation 21.41.51.8-1.31.21.31.31.31.31.21.21.31.21.21.2
Intermitt. access day 1 inactive lever presses0.00.00.00.2-0.2-0.1-0.0-0.1-0.10.1-0.1-0.1-0.1-0.10.0
Intermitt. access day 15 inactive lever presses0.10.10.4-0.70.60.60.20.40.20.20.20.1-0.1-0.1-0.1
Intermitt. access escalation Index0.20.20.7-0.20.20.30.50.50.60.80.50.40.30.30.8
Intermittent access day 1 total infusions2.74.45.2-2.32.32.22.32.02.12.32.12.01.71.72.0
Intermittent access day 15 total infusions3.24.75.6-2.32.32.32.42.22.32.32.22.11.81.82.1
Intermittent access terminal intake (last 3 days)2.12.84.0-2.02.01.91.81.71.71.61.71.51.21.21.5
Intermittent access total infusions2.22.64.3-2.12.02.01.71.61.61.61.61.31.01.01.2
Intermittent access day 1 locomotion2.33.03.6-1.71.71.71.91.61.71.91.71.71.61.61.7
Intermittent access day 15 total locomotion1.42.53.0-1.61.51.61.71.61.71.71.61.61.41.41.6
Intermittent access total locomotion1.41.62.2-1.51.41.41.41.31.31.31.21.21.01.01.1
Intermittent access standard deviation1.42.84.0-2.02.01.91.81.61.71.61.61.61.41.41.4
Left kidney weight0.62.73.2-1.81.71.71.71.61.71.71.51.61.61.61.4
Right kidney weight0.94.35.6-2.42.32.32.02.22.12.01.92.02.02.01.6
Cocaine induced anxiety0.81.11.50.7-0.7-0.8-1.1-0.9-1.1-1.1-1.0-1.1-1.2-1.2-1.2
Post-drug Anxiety5.55.87.22.0-2.0-2.0-2.6-2.2-2.6-2.5-2.4-2.6-2.7-2.7-2.7
Baseline Anxiety1.61.92.11.3-1.3-1.3-1.4-1.4-1.4-1.4-1.4-1.4-1.2-1.2-1.4
Tail length0.10.30.7-0.80.80.80.60.60.50.60.50.40.40.40.3
Length with tail0.20.81.3-1.21.11.10.90.90.81.00.80.70.70.70.6
Length without tail0.20.61.2-1.11.01.00.70.80.70.70.70.60.60.60.4
Times rat made contact with spout0.00.00.1-0.20.20.1-0.1-0.0-0.1-0.4-0.1-0.2-0.2-0.2-0.4
Lifetime Intake1.82.24.0-2.02.01.91.61.51.51.51.51.20.90.91.1
Liver weight, left1.52.43.0-1.51.51.51.51.61.51.71.51.51.51.51.5
Liver weight, right0.91.71.8-1.31.31.31.31.21.31.31.21.31.31.31.1
Locomotor activity0.30.51.2-0.20.20.40.70.70.80.90.70.70.70.71.1
Locomotor testing distance1.42.53.2-1.31.31.41.71.61.71.71.61.71.61.61.8
Locomotor testing rearing0.81.52.6-0.70.70.81.31.01.31.41.21.41.51.51.6
Locomotion in novel chamber0.40.51.1-1.01.00.90.60.70.70.50.60.70.60.60.3
Locomotion in novel chamber post-restriction0.71.21.51.2-1.2-1.2-1.1-0.9-1.1-1.1-1.1-1.0-1.0-1.0-1.0
Fecal boli incidents, locomotor time 15.27.610.03.2-3.1-3.1-2.7-2.9-2.7-2.7-2.7-2.5-2.5-2.5-2.3
Change in fecal boli incidents, locomotor task7.97.89.0-3.03.03.02.82.72.72.92.82.72.72.72.5
Time >=10cm from walls, locomotor time 10.50.51.3-0.00.00.10.70.40.80.90.70.80.80.81.1
Bouts of movement, locomotor time 12.63.03.61.4-1.5-1.5-1.7-1.8-1.8-1.7-1.8-1.9-1.8-1.8-1.9
Total resting periods, locomotor time 12.12.42.81.3-1.3-1.4-1.5-1.6-1.6-1.5-1.6-1.6-1.6-1.6-1.7
Rest time, locomotor task time 10.60.81.11.0-1.0-1.0-0.8-1.0-0.9-0.6-0.9-0.9-0.8-0.8-0.8
Distance moved, locomotor task time 10.40.61.6-1.31.21.20.60.80.60.50.60.50.40.40.1
Vertical activity count, locomotor time 10.00.00.0-0.20.20.20.00.10.1-0.00.00.0-0.0-0.0-0.1
Time >=10cm from walls, locomotor time 23.95.86.2-2.52.52.52.42.42.42.52.42.42.42.42.3
Bouts of movement, locomotor time 20.00.00.10.4-0.3-0.3-0.1-0.1-0.2-0.2-0.1-0.1-0.1-0.10.1
Total resting periods, locomotor time 20.00.00.10.2-0.2-0.10.10.10.10.10.10.20.20.20.4
Rest time, locomotor task time 20.20.30.91.0-0.9-0.80.1-0.5-0.00.3-0.10.10.10.10.6
Distance moved, locomotor task time 20.50.62.2-1.51.41.2-0.00.6-0.0-0.20.1-0.2-0.3-0.3-1.0
Vertical activity count, locomotor time 20.20.31.1-1.11.00.9-0.10.60.1-0.30.1-0.1-0.1-0.1-0.7
Light reinforcement 10.00.10.2-0.40.40.4-0.10.2-0.20.3-0.0-0.2-0.2-0.2-0.4
Light reinforcement 20.20.30.80.1-0.1-0.1-0.5-0.3-0.7-0.2-0.6-0.7-0.6-0.6-0.9
Bone: marrow area0.40.81.00.9-0.9-0.9-0.8-1.0-0.9-0.7-1.0-0.9-0.9-0.9-0.9
Bone: maximum diameter0.00.10.3-0.10.00.0-0.2-0.1-0.2-0.0-0.3-0.2-0.2-0.2-0.5
Bone: maximum force0.00.00.1-0.40.30.30.10.20.10.00.10.10.10.1-0.2
Bone: maximum moment0.00.00.1-0.00.0-0.0-0.2-0.1-0.1-0.2-0.2-0.2-0.2-0.2-0.3
Mean time between licks in bursts0.10.40.91.0-0.9-0.9-0.3-0.8-0.3-0.7-0.5-0.1-0.1-0.1-0.0
Mean num. licks in bursts0.00.00.1-0.20.20.20.10.20.10.10.2-0.0-0.1-0.10.1
Cd content in liver5.66.26.8-2.42.42.52.52.52.52.42.62.52.62.62.5
Co content in liver1.51.82.01.3-1.3-1.3-1.3-1.4-1.4-1.2-1.3-1.4-1.4-1.4-1.2
Cu content in liver2.53.03.71.6-1.7-1.6-1.7-1.8-1.7-1.3-1.8-1.9-1.9-1.9-1.7
Fe content in liver0.30.40.70.8-0.9-0.8-0.5-0.8-0.6-0.4-0.6-0.5-0.5-0.5-0.3
K content in liver7.47.19.12.2-2.2-2.3-2.7-2.6-2.8-2.5-2.7-3.0-3.0-3.0-2.9
Mg content in liver5.15.26.51.9-1.9-2.0-2.2-2.3-2.4-2.1-2.3-2.5-2.5-2.5-2.5
Mn content in liver1.92.12.41.3-1.4-1.4-1.4-1.5-1.4-1.5-1.4-1.5-1.6-1.6-1.4
Na content in liver0.10.10.20.1-0.2-0.2-0.4-0.2-0.3-0.3-0.3-0.4-0.4-0.4-0.4
Rb content in liver1.41.72.21.2-1.2-1.2-1.3-1.2-1.3-1.2-1.2-1.4-1.5-1.5-1.2
Se content in liver5.46.47.52.6-2.6-2.6-2.4-2.7-2.5-2.5-2.5-2.5-2.4-2.4-2.4
Sr content in liver0.90.81.00.8-0.8-0.8-0.9-0.9-0.9-1.0-0.9-0.8-0.8-0.8-1.0
Zn content in liver0.10.10.1-0.30.30.3-0.10.0-0.10.1-0.1-0.3-0.3-0.3-0.3
Bone: minimum diameter0.00.10.2-0.40.30.30.00.1-0.00.2-0.1-0.1-0.1-0.1-0.4
Time in familiar zone, hab. session 10.10.10.30.5-0.5-0.5-0.3-0.4-0.3-0.1-0.2-0.2-0.1-0.1-0.0
Time in novel zone, hab. session 10.10.10.3-0.60.50.50.10.40.10.10.10.1-0.0-0.0-0.2
Total zone transitions, hab. session 13.54.95.5-2.02.12.12.22.32.32.02.22.32.32.32.3
Total locomotion distance, hab. session 12.33.24.2-1.51.51.51.91.71.91.71.81.91.91.92.0
Locomotion velocity, hab. session 11.92.74.0-1.31.31.41.81.51.81.71.71.71.71.72.0
Time in familiar zone, hab. session 20.20.20.50.1-0.1-0.1-0.5-0.4-0.5-0.2-0.4-0.7-0.7-0.7-0.6
Time in novel zone, hab. session 20.10.10.3-0.10.20.10.40.30.30.20.30.50.50.50.4
Total zone transitions, hab. session 21.62.12.4-1.51.61.51.41.51.41.21.41.41.41.41.3
Total locomotion distance, hab. session 20.40.50.9-0.40.40.50.80.60.70.70.70.80.80.80.9
Locomotion velocity, hab. session 20.20.30.6-0.30.30.30.60.40.50.60.50.60.60.60.7
Novel to familiar place preference ratio0.80.91.1-1.11.01.00.91.00.90.90.90.80.80.80.8
Novelty place preference0.70.71.0-1.01.01.00.81.00.90.90.80.80.70.70.7
Time in novel zone, NPP test0.50.60.7-0.90.80.80.70.90.80.80.70.70.70.70.6
Total zone transitions, NPP test0.10.10.30.6-0.5-0.5-0.2-0.3-0.2-0.5-0.1-0.0-0.0-0.00.1
Total locomotion distance, NPP test0.10.10.40.4-0.3-0.30.2-0.00.2-0.00.20.40.40.40.6
Locomotion velocity, NPP test0.10.10.40.3-0.2-0.20.30.10.30.10.30.50.50.50.7
Intraocular pressure0.00.00.1-0.10.10.10.20.10.20.30.20.20.30.30.2
Delta distance traveled before/after self-admin0.10.10.30.5-0.5-0.5-0.3-0.3-0.3-0.3-0.3-0.1-0.1-0.1-0.0
Delta ambulatory time before/after self-admin0.10.10.20.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.3-0.3-0.3-0.3
Parametrial fat weight0.10.30.5-0.60.60.60.40.60.50.70.50.40.40.40.3
Pavlov. Cond. lever latency0.50.60.90.9-0.9-0.9-0.8-0.9-0.8-0.8-0.8-0.7-0.7-0.7-0.7
Pavlov. Cond. magazine entry latency1.21.61.7-1.31.31.31.31.31.31.01.31.31.31.31.2
Pavlov. Cond. change in total contacts0.50.50.80.4-0.5-0.5-0.7-0.6-0.7-0.7-0.7-0.8-0.9-0.9-0.9
Pavlov. Cond. index score0.60.80.9-0.90.90.90.90.90.90.70.90.90.80.80.8
Pavlov. Cond. latency score0.60.70.9-0.91.00.90.81.00.90.70.90.80.80.80.8
Pavlov. Cond. lever contacts0.40.50.6-0.80.80.80.70.80.70.70.70.70.70.70.6
Pavlov. Cond. magazine entry number1.51.92.11.4-1.4-1.4-1.4-1.4-1.4-1.1-1.4-1.4-1.4-1.4-1.4
Pavlov. Cond. intertrial magazine entries0.00.00.00.1-0.1-0.00.10.00.10.10.10.20.20.20.2
Pavlov. Cond. lever-magazine prob. diff.0.60.80.9-0.90.90.90.90.90.90.70.90.90.80.80.8
Pavlov. Cond. response bias1.51.92.0-1.41.41.41.41.41.41.21.41.41.31.31.4
Pavlov. Cond. lever latency2.43.23.51.8-1.8-1.8-1.8-1.8-1.8-1.8-1.9-1.8-1.8-1.8-1.8
Pavlov. Cond. magazine entry latency1.11.31.5-1.21.21.21.21.11.11.11.11.21.21.21.0
Pavlov. Cond. change in total contacts0.61.01.3-1.11.11.10.91.11.01.01.00.90.90.90.8
Pavlov. Cond. index score2.02.62.9-1.71.71.71.61.61.61.51.61.61.61.61.5
Pavlov. Cond. latency score2.43.23.5-1.91.91.91.81.81.81.71.81.81.81.81.6
Pavlov. Cond. lever contacts2.83.84.0-2.02.02.02.02.02.02.02.01.91.91.91.9
Pavlov. Cond. magazine entry number0.80.91.21.1-1.1-1.0-0.9-0.9-0.9-0.9-0.9-0.9-1.0-1.0-0.8
Pavlov. Cond. intertrial magazine entries0.00.00.20.4-0.4-0.3-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.10.2
Pavlov. Cond. lever-magazine prob. diff.1.62.12.3-1.51.51.51.41.41.51.31.51.41.51.51.3
Pavlov. Cond. response bias2.63.53.7-1.91.91.91.91.91.91.81.91.91.91.91.9
Time in closed arm before self-admin0.30.30.9-0.90.90.90.50.60.50.40.50.20.10.10.2
Time in closed arm after self-admin0.20.20.2-0.50.40.40.50.30.40.40.40.40.30.30.4
Time in open arm before self-admin0.40.51.71.3-1.3-1.1-0.3-0.6-0.2-0.2-0.3-0.0-0.1-0.10.4
Time in open arm after self-admin0.40.40.80.9-0.9-0.8-0.6-0.6-0.6-0.5-0.6-0.6-0.5-0.4-0.4
Bone: periosteal estimation0.30.71.10.6-0.7-0.7-0.8-0.8-0.9-0.7-0.9-0.9-0.9-0.9-1.0
Bone: periosteal perimeter0.40.71.3-1.11.11.10.80.90.81.00.70.70.70.70.4
Bone: post-yield work0.10.20.4-0.30.30.30.50.30.50.30.40.60.60.60.5
Progressive ratio test 1 active lever presses1.82.23.3-1.81.81.71.61.51.51.61.51.20.90.91.3
Progressive ratio test 1 breakpoint1.62.03.2-1.81.81.71.61.51.41.51.41.20.80.81.2
Progressive ratio test 1 inactive lever presses1.52.12.9-1.41.41.51.61.41.51.71.51.41.21.21.6
Progressive ratio test 2 active lever presses2.63.16.2-2.52.52.41.71.91.61.61.71.30.90.91.1
Progressive ratio test 2 breakpoint2.93.46.6-2.62.52.41.82.01.71.71.81.41.01.01.1
Progressive ratio test 2 inactive lever presses0.81.43.3-1.81.81.71.11.31.01.21.00.60.20.20.5
Incentive Sensitization - Responses1.92.75.6-2.42.42.21.51.81.41.51.61.21.11.10.9
Incentive Sensitization - Breakpoint2.12.85.5-2.32.32.21.51.81.51.51.61.31.11.10.9
Sum of active levers in priming session hrs 5-61.31.22.30.9-1.0-0.9-1.0-0.9-0.9-1.0-1.0-1.3-1.5-1.5-1.0
Progressive ratio0.10.20.4-0.70.60.60.40.30.30.40.40.20.30.30.2
Food seeking constrained by brief footshock0.40.40.9-0.90.90.90.60.60.60.70.60.50.40.40.4
Seeking ratio, punishment vs. effort0.00.00.10.2-0.2-0.2-0.2-0.1-0.1-0.1-0.2-0.1-0.1-0.1-0.1
Retroperitoneal fat weight6.628.038.5-6.26.16.05.15.75.15.45.04.84.74.74.1
Reaction time number correct0.00.10.10.2-0.2-0.2-0.4-0.2-0.3-0.2-0.2-0.3-0.3-0.3-0.2
Reaction time mean minus median0.41.01.3-1.11.11.10.91.21.00.81.01.01.01.00.8
Reaction time mean minus median AUC0.20.50.8-0.90.90.80.60.90.70.60.70.60.60.60.5
Reaction time num false alarms0.91.31.91.4-1.4-1.4-1.1-1.3-1.1-1.2-1.1-1.0-0.9-0.9-0.9
Reaction time num false alarms AUC1.21.93.01.7-1.7-1.7-1.3-1.6-1.3-1.3-1.3-1.2-1.2-1.2-1.0
Reaction time trials correct on left0.00.10.10.2-0.2-0.2-0.4-0.2-0.3-0.2-0.2-0.3-0.3-0.3-0.2
Reaction time trials on left0.00.10.20.3-0.3-0.2-0.4-0.2-0.3-0.2-0.3-0.4-0.3-0.3-0.2
Reaction time mean0.10.20.4-0.60.60.60.50.40.40.20.40.40.40.40.2
Reaction time mean AUC0.10.20.5-0.70.70.60.50.40.40.20.40.40.40.40.2
Median of all reaction times0.10.20.4-0.60.60.50.50.30.40.20.40.30.30.30.2
Reaction time omissions0.10.20.50.7-0.7-0.6-0.3-0.5-0.3-0.5-0.3-0.2-0.2-0.2-0.0
Reaction time false alarm rate1.52.13.11.8-1.7-1.7-1.4-1.6-1.4-1.5-1.4-1.3-1.3-1.3-1.1
Reaction time premature initiation rate0.10.20.50.2-0.2-0.10.20.30.30.30.30.50.60.60.7
Reaction time premature initiations0.00.10.30.3-0.3-0.20.10.20.20.20.20.30.40.40.5
Std. dev. reaction times0.10.10.2-0.40.40.40.20.40.30.20.30.30.30.30.1
Reaction time trials completed0.00.10.20.3-0.3-0.2-0.4-0.2-0.3-0.2-0.3-0.4-0.3-0.3-0.2
Reaction time trials AUC0.00.00.10.1-0.1-0.1-0.2-0.0-0.2-0.1-0.1-0.2-0.2-0.2-0.1
Run reversals in cocaine runway, females0.00.00.1-0.20.20.20.2-0.10.10.10.00.00.10.1-0.0
Run reversals in cocaine runway, males2.32.33.21.8-1.8-1.7-1.5-1.5-1.5-1.3-1.5-1.5-1.5-1.5-1.2
Latency to leave start box in cocaine runway0.20.30.70.00.00.10.50.10.40.50.40.70.80.80.7
Latency to leave start box in cocaine runway, F1.41.62.4-0.80.80.81.31.01.31.31.21.51.51.51.6
Latency to leave start box in cocaine runway, M1.41.32.01.1-1.1-1.1-1.1-1.4-1.3-1.2-1.2-1.0-0.9-0.9-1.3
Std. dev. time between licks in bursts0.10.20.50.7-0.7-0.7-0.3-0.5-0.3-0.5-0.4-0.1-0.1-0.1-0.1
Total sessions with >9 infusions1.92.32.9-1.61.61.61.71.51.61.51.51.61.31.31.5
Short access day 1 total inactive lever presses2.12.74.1-1.41.41.51.81.51.82.01.71.71.41.42.0
Short access day 10 total inactive lever presses0.00.00.1-0.30.30.30.10.30.20.20.20.10.10.10.2
Short access day 1 total infusions1.52.03.0-1.71.71.71.61.31.41.51.51.31.01.01.3
Short access day 10 total infusions1.51.92.9-1.71.71.61.51.51.41.31.31.31.11.11.0
Short access total infusions1.92.43.5-1.91.81.81.71.51.51.51.51.41.21.21.3
Short access day 1 locomotion2.83.54.7-1.71.61.72.21.72.02.11.92.01.71.72.1
Short access day 10 total locomotion1.83.34.0-2.02.01.91.81.71.71.71.71.81.91.91.5
Short access total locomotion2.73.33.8-1.91.91.81.91.71.81.71.71.91.81.81.6
One hour access (0.3 mA shock)4.34.97.0-2.62.62.52.42.12.22.32.22.01.71.71.9
Compulsive drug intake1.11.32.11.4-1.4-1.3-1.1-1.3-1.0-0.7-1.0-1.1-1.1-1.1-0.6
One hour access (shock baseline)3.24.98.1-2.82.82.72.32.32.12.02.12.01.81.81.5
Social response proportion3.74.25.22.2-2.2-2.1-1.9-2.0-1.9-1.9-1.9-2.1-2.3-2.3-1.6
Social responses0.10.10.2-0.30.30.30.40.40.40.40.40.20.10.10.4
Social time1.21.71.91.4-1.3-1.3-1.3-1.2-1.2-1.3-1.2-1.3-1.4-1.4-1.1
Soleus weight1.13.23.92.0-2.0-1.9-1.7-1.9-1.8-1.6-1.7-1.8-1.8-1.8-1.4
Bone: stiffness0.40.70.9-1.00.90.90.90.80.90.70.80.90.90.90.6
Tibialis anterior weight3.311.211.93.4-3.4-3.4-3.4-3.3-3.4-3.1-3.3-3.4-3.4-3.4-3.1
Time to tail flick, vehicle, before self-admin0.70.82.1-1.41.41.30.61.20.70.80.70.2-0.0-0.00.1
Time to tail flick, vehicle, after self-admin1.72.23.9-2.02.01.91.41.61.41.31.51.21.21.21.0
Time to tail flick, test, before self-admin0.10.10.5-0.70.70.60.10.20.10.10.20.10.20.2-0.2
Time to tail flick, test, after self-admin0.30.31.1-1.01.00.90.10.50.20.00.2-0.0-0.2-0.2-0.4
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.10.20.10.30.00.20.10.30.60.70.70.4
Delta time to tail flick, test, before/after SA0.10.10.3-0.30.30.30.50.40.50.40.40.40.20.20.6
Tibia length0.51.31.71.1-1.1-1.1-1.2-1.1-1.2-1.3-1.2-1.1-1.0-1.0-1.2
Ambulatory time before self-admin0.20.40.60.4-0.4-0.5-0.6-0.6-0.7-0.7-0.7-0.6-0.6-0.6-0.8
Ambulatory time after self-admin0.10.10.30.2-0.2-0.3-0.4-0.4-0.5-0.5-0.5-0.3-0.2-0.2-0.6
Bone: tissue strength0.00.00.1-0.10.00.0-0.10.0-0.10.0-0.1-0.2-0.2-0.2-0.2
Total heroin consumption0.30.30.70.8-0.8-0.8-0.4-0.6-0.4-0.4-0.5-0.4-0.6-0.6-0.2
Bone: trabecular number0.40.70.9-0.90.90.81.00.80.90.80.90.90.80.80.8
Bone: trabecular spacing0.40.60.7-0.80.80.80.70.70.70.70.70.70.80.80.7
Bone: trabecular thickness0.20.30.5-0.70.70.70.50.60.50.50.50.50.40.40.4
Bone: trabecular tissue density0.91.31.71.0-1.1-1.1-1.2-1.1-1.2-1.0-1.2-1.1-1.0-1.0-1.3
Water consumed over 24 hours0.20.30.8-0.10.1-0.0-0.5-0.3-0.5-0.5-0.5-0.7-0.7-0.7-0.9
Number of responses in last shaping day0.90.92.2-1.51.41.40.91.00.80.90.90.60.40.40.4