P2rx5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression P2rx5 0.09 0.07 5.5e-03 0.04 0.03 0.01 0.03 6.3e-03 2.8e-02 1.3e-01 2.4e-02
2 Liver gene expression P2rx5 0.53 0.1 0.0e+00 0.41 0.39 0.4 0.4 4.0e-48 2.6e-46 8.5e-47 2.1e-47
3 Liver alternative TSS XM_006246566.4 0.1 0.05 5.8e-10 0.07 0.06 0.06 0.06 6.4e-08 2.9e-07 8.0e-07 3.1e-07
4 Liver isoform ratio NM_080780.3 0.06 0.04 4.5e-05 0.02 0.01 0.01 0.02 8.9e-04 7.8e-03 2.4e-02 6.2e-03
5 Liver isoform ratio XM_006246566.4 0.06 0.04 4.4e-05 0.03 0.02 0.01 0.02 6.7e-04 6.4e-03 1.5e-02 5.1e-03
6 Liver alternative TSS NM_080780.3 0.09 0.05 1.2e-09 0.06 0.06 0.05 0.06 5.3e-07 4.3e-07 2.5e-06 6.5e-07
7 Adipose mRNA stability P2rx5 0.09 0.05 3.5e-06 0.02 0.04 0.04 0.04 1.7e-03 8.9e-05 5.4e-05 7.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.50.81.9-0.8-0.8-0.70.7-0.7-0.9-1.4
Area under the delay curve0.20.20.40.60.40.5-0.50.50.40.2
BMI with tail0.10.30.90.50.50.5-0.50.50.5-0.9
BMI without tail0.20.41.60.20.50.5-0.50.50.1-1.3
Body weight0.41.66.8-0.8-0.8-0.70.7-0.7-1.3-2.6
Weight adjusted by age2.52.83.31.61.81.7-1.71.71.6-1.7
Bone surface0.30.62.10.40.60.6-0.60.60.5-1.4
Bone volume0.50.92.80.70.80.9-0.90.90.6-1.7
Breakpoint value in progressive ratio session0.30.42.5-0.00.00.0-0.00.0-0.1-1.6
Number of licking bursts0.10.10.3-0.2-0.4-0.40.4-0.4-0.20.6
Context. condit. distance diff. score0.40.52.20.20.40.5-0.50.50.4-1.5
Locomotion velocity, session 10.70.85.00.50.10.2-0.20.2-0.3-2.2
Locomotion distance, session 10.81.01.31.10.91.0-1.01.00.7-1.1
Locomotion velocity, session 20.80.91.6-1.1-1.0-1.01.0-1.0-1.3-0.3
Locomotion distance, session 20.10.10.8-0.1-0.1-0.10.1-0.1-0.3-0.9
Locomotion velocity, session 31.21.43.1-1.2-1.0-1.01.0-1.0-1.01.8
Locomotion distance, session 30.20.20.3-0.5-0.4-0.40.4-0.4-0.30.4
Stereotopy head waving bouts, day 30.10.10.2-0.4-0.3-0.30.3-0.3-0.5-0.0
Stereotopy head waving duration, day 30.70.91.10.71.01.0-1.01.00.90.7
Locomotion velocity, session 70.10.10.10.10.30.3-0.30.30.4-0.1
Locomotion distance, session 70.00.00.1-0.3-0.2-0.30.3-0.3-0.0-0.0
Stereotopy head waving bouts, day 70.40.41.20.30.70.6-0.60.60.3-1.1
Stereotopy head waving duration, day 70.50.51.80.30.80.6-0.60.60.3-1.3
Locomotion velocity, session 80.60.71.30.70.80.9-0.90.90.7-1.1
Locomotion distance, session 80.50.74.6-0.00.10.3-0.30.3-0.1-2.1
Degree of sensitization distance0.50.50.80.80.60.6-0.60.60.5-0.9
Degree of sensitization stereotypy0.30.42.3-0.10.30.2-0.20.2-0.2-1.5
Conditioned locomotion0.30.31.8-0.2-0.3-0.30.3-0.30.01.3
Cocaine response after cond. corrected1.01.11.4-1.1-1.1-1.21.2-1.2-1.1-0.2
Cocaine response after cond. not corrected0.60.60.8-0.9-0.8-0.80.8-0.8-0.9-0.4
Cocaine response before conditioning0.50.60.80.70.80.8-0.80.80.6-0.9
Saline control response0.30.40.70.80.60.6-0.60.60.5-0.8
Bone: connectivity density0.30.52.8-0.5-0.3-0.20.2-0.2-0.4-1.7
Bone: cortical apparent density0.40.61.7-0.7-0.7-0.70.7-0.7-0.31.3
Bone: cortical area0.20.30.70.40.40.5-0.50.50.40.8
Bone: cortical porosity2.83.03.8-1.9-1.9-1.81.8-1.8-2.00.4
Bone: cortical porosity2.42.63.2-1.8-1.7-1.71.7-1.7-1.80.6
Bone: cortical thickness1.32.14.0-1.3-1.4-1.31.3-1.3-1.32.0
Bone: cortical thickness4.65.36.3-2.3-2.5-2.42.4-2.4-2.51.3
Bone: cortical tissue density0.40.51.3-0.7-0.7-0.70.7-0.7-0.31.1
Condit. Reinf. active minus inactive responses1.41.52.1-1.0-1.4-1.41.4-1.4-1.30.3
Condit. Reinf. active-inactive response ratio0.90.91.2-0.7-1.1-1.11.1-1.1-1.10.3
Condit. Reinf. active responses1.01.21.8-0.8-1.3-1.31.3-1.3-1.10.1
Condit. Reinf. inactive responses0.00.00.0-0.1-0.2-0.10.1-0.10.10.2
Incentive salience index mean2.12.53.5-1.2-1.9-1.81.8-1.8-1.80.1
Condit. Reinf. lever presses3.14.15.6-1.7-2.4-2.22.2-2.2-2.3-0.5
Condit. Reinf. active minus inactive responses1.01.21.5-0.9-1.2-1.21.2-1.2-1.20.0
Condit. Reinf. active-inactive response ratio1.11.21.5-0.9-1.2-1.21.2-1.2-1.20.3
Condit. Reinf. active responses0.40.50.7-0.5-0.9-0.90.9-0.9-0.8-0.1
Condit. Reinf. inactive responses0.20.20.40.60.40.4-0.40.40.6-0.0
Condit. Reinf. lever presses0.10.10.90.3-0.1-0.10.1-0.10.10.9
Condit. Reinf. lever reinforcers received0.30.40.5-0.3-0.7-0.70.7-0.7-0.60.0
Conditioned reinforcement - actives0.90.91.31.10.90.9-0.90.91.0-0.8
Conditioned reinforcement - inactives1.61.82.61.61.41.3-1.31.31.4-1.1
Conditioned locomotion0.91.02.01.41.21.0-1.01.01.10.0
Patch foraging indifference point 0 sec1.82.93.5-1.8-1.8-1.81.8-1.8-1.90.5
Patch foraging indifference point AUC3.23.64.41.92.12.1-2.12.12.1-0.3
Delay disc. indifference point, 0s delay2.02.22.71.61.51.6-1.61.61.4-1.0
Delay disc. indifference point, 16s delay1.01.01.41.21.01.1-1.11.11.20.1
Delay disc. indifference point, 2s delay0.10.10.3-0.2-0.2-0.00.0-0.0-0.20.6
Delay disc. indifference point, 24s delay0.50.50.7-0.4-0.8-0.70.7-0.7-0.60.7
Delay disc. indifference point, 4s delay0.50.60.80.90.80.8-0.80.80.7-0.5
Delay disc. indifference point, 8s delay0.00.00.20.40.10.2-0.20.20.1-0.0
Indifference point function ln k7.810.912.9-3.4-3.5-3.63.6-3.6-3.41.4
Indifference point function log k7.810.912.9-3.4-3.5-3.63.6-3.6-3.41.4
Patch foraging total patch changes 0 sec1.21.92.4-1.4-1.5-1.51.5-1.5-1.60.4
Patch foraging total patch changes 12 sec1.21.62.11.41.41.3-1.31.31.1-0.8
Patch foraging total patch changes 18 sec0.70.81.10.91.11.0-1.01.00.8-0.5
Patch foraging total patch changes 24 sec0.80.91.31.11.11.0-1.01.01.0-0.1
Patch foraging total patch changes 6 sec1.82.63.81.71.91.7-1.71.71.7-0.4
Patch foraging time to switch 0 sec1.01.62.01.31.41.3-1.31.31.0-1.2
Patch foraging water rate 0 sec0.50.71.5-0.9-0.8-0.80.8-0.8-0.61.2
Patch foraging water rate 12 sec0.10.10.4-0.10.00.2-0.20.2-0.1-0.7
Patch foraging water rate 18 sec0.91.32.4-0.9-1.5-1.21.2-1.2-1.2-0.4
Patch foraging water rate 24 sec0.00.00.00.0-0.10.2-0.20.20.10.2
Patch foraging water rate 6 sec0.20.30.7-0.5-0.5-0.50.5-0.5-0.40.9
Seeking ratio, delayed vs. immediate footshock0.20.31.2-0.5-0.2-0.30.3-0.3-0.31.1
Distance traveled before self-admin1.01.01.41.01.11.1-1.11.11.20.4
Distance traveled after self-admin6.87.69.63.13.02.9-2.92.92.6-1.7
Extensor digitorum longus weight2.911.512.83.63.43.4-3.43.43.2-3.3
Bone: elastic displacement0.10.10.60.10.20.2-0.20.20.40.8
Bone: elastic work0.40.52.1-0.6-0.5-0.50.5-0.5-0.51.4
Bone: endosteal estimation3.78.19.53.03.13.1-3.13.12.9-1.2
Bone: endosteal perimeter3.87.99.23.03.03.0-3.03.02.9-1.4
Epididymis fat weight1.94.412.32.01.71.8-1.81.81.4-3.5
Delta time in closed arm before/after self-admin1.81.72.51.61.21.4-1.41.41.3-0.4
Delta time in open arm before/after self-admin0.40.41.00.50.80.5-0.50.50.5-1.0
Diff in mean of infusions in LGA sessions0.80.91.0-0.9-1.0-1.01.0-1.0-0.9-0.8
Delay discount exponential model param0.00.00.1-0.3-0.0-0.10.1-0.1-0.1-0.3
Extinction: sum of active levers before priming0.40.42.90.00.20.2-0.20.2-0.1-1.7
Active lever presses in extinction session 60.80.82.60.80.70.6-0.60.60.5-1.6
Bone: final force0.50.81.00.90.91.0-1.01.00.6-0.7
Bone: final moment0.61.01.31.11.11.1-1.11.10.8-0.6
Food consumed during 24 hour testing period0.91.11.3-1.1-1.1-1.11.1-1.1-1.10.1
Glucose0.81.32.91.10.90.9-0.90.91.21.7
Heart weight0.70.91.71.01.00.9-0.90.90.8-1.3
Delay discount hyperbolic model param0.10.10.2-0.4-0.1-0.20.2-0.2-0.2-0.2
Intermittent access intake day 1-15 change3.02.94.42.11.81.7-1.71.72.00.7
Intermittent access intake escalation3.13.04.42.11.71.7-1.71.72.01.0
Intermittent access intake escalation 21.71.72.71.41.01.2-1.21.21.41.6
Intermitt. access day 1 inactive lever presses0.30.31.40.20.50.0-0.00.00.51.2
Intermitt. access day 15 inactive lever presses0.20.20.3-0.4-0.5-0.50.5-0.5-0.50.5
Intermitt. access escalation Index0.60.62.6-0.5-0.3-0.30.3-0.3-0.8-1.6
Intermittent access day 1 total infusions1.92.22.51.51.61.4-1.41.41.3-1.6
Intermittent access day 15 total infusions7.38.210.83.33.22.9-2.92.93.1-0.9
Intermittent access terminal intake (last 3 days)5.15.58.02.82.52.4-2.42.42.3-1.5
Intermittent access total infusions3.33.65.02.22.21.9-1.91.92.0-1.0
Intermittent access day 1 locomotion1.51.63.11.21.81.2-1.21.21.2-1.0
Intermittent access day 15 total locomotion2.62.84.12.01.91.7-1.71.71.80.0
Intermittent access total locomotion0.70.82.01.11.40.8-0.80.80.9-0.3
Intermittent access standard deviation7.98.411.43.43.22.9-2.92.93.40.4
Left kidney weight0.20.60.90.70.91.0-1.01.00.6-0.1
Right kidney weight0.10.30.50.50.50.7-0.70.70.4-0.2
Cocaine induced anxiety1.92.23.2-1.3-1.4-1.51.5-1.5-1.21.8
Post-drug Anxiety0.91.01.1-1.0-1.1-1.01.0-1.0-0.90.7
Baseline Anxiety1.11.11.41.00.81.2-1.21.21.0-1.1
Tail length0.61.99.5-0.5-0.6-0.40.4-0.4-1.5-3.1
Length with tail0.62.05.9-1.1-1.1-1.01.0-1.0-1.8-2.4
Length without tail0.30.73.0-0.4-0.6-0.50.5-0.5-0.7-1.7
Times rat made contact with spout1.31.51.8-1.2-1.3-1.31.3-1.3-1.30.7
Lifetime Intake4.65.36.92.62.62.3-2.32.32.4-1.3
Liver weight, left0.50.81.3-0.9-0.8-0.80.8-0.8-1.1-0.8
Liver weight, right0.30.42.60.20.30.2-0.20.2-0.3-1.6
Locomotor activity0.40.71.11.10.80.7-0.70.70.6-0.9
Locomotor testing distance2.74.65.72.42.42.2-2.22.22.0-1.4
Locomotor testing rearing4.67.18.93.02.82.8-2.82.82.7-1.3
Locomotion in novel chamber2.42.94.21.51.51.8-1.81.82.11.4
Locomotion in novel chamber post-restriction0.20.20.5-0.3-0.4-0.50.5-0.5-0.30.7
Fecal boli incidents, locomotor time 10.50.51.1-1.1-0.6-0.70.7-0.7-0.70.4
Change in fecal boli incidents, locomotor task0.50.50.6-0.7-0.7-0.70.7-0.7-0.70.6
Time >=10cm from walls, locomotor time 10.50.50.7-0.8-0.7-0.80.8-0.8-0.80.3
Bouts of movement, locomotor time 11.11.22.0-1.4-1.1-1.11.1-1.1-1.00.3
Total resting periods, locomotor time 12.32.53.4-1.8-1.6-1.71.7-1.7-1.50.9
Rest time, locomotor task time 10.30.40.8-0.9-0.5-0.50.5-0.5-0.40.9
Distance moved, locomotor task time 11.41.52.71.71.11.2-1.21.21.2-0.9
Vertical activity count, locomotor time 10.91.01.41.20.91.0-1.01.00.8-1.1
Time >=10cm from walls, locomotor time 20.60.70.9-0.8-0.9-0.80.8-0.8-0.80.6
Bouts of movement, locomotor time 21.51.62.1-1.5-1.2-1.41.4-1.4-1.20.7
Total resting periods, locomotor time 21.21.21.7-1.3-1.1-1.21.2-1.2-1.10.5
Rest time, locomotor task time 20.91.11.4-1.2-1.0-1.01.0-1.0-0.81.2
Distance moved, locomotor task time 23.43.96.62.61.72.1-2.12.12.0-0.8
Vertical activity count, locomotor time 21.01.01.71.30.91.1-1.11.10.8-0.9
Light reinforcement 11.52.83.41.81.61.8-1.81.81.6-1.2
Light reinforcement 20.30.40.50.40.50.7-0.70.70.6-0.0
Bone: marrow area3.67.99.32.93.03.1-3.13.12.8-1.2
Bone: maximum diameter1.32.33.01.71.61.6-1.61.61.6-0.0
Bone: maximum force0.61.11.41.11.11.2-1.21.20.8-0.7
Bone: maximum moment0.91.51.91.31.31.4-1.41.41.0-0.5
Mean time between licks in bursts0.60.93.00.70.80.8-0.80.80.4-1.7
Mean num. licks in bursts0.10.20.3-0.5-0.4-0.40.4-0.4-0.5-0.2
Cd content in liver0.80.91.50.90.90.9-0.90.90.9-1.2
Co content in liver0.10.10.30.20.30.4-0.40.40.3-0.5
Cu content in liver2.93.54.2-2.0-2.0-2.02.0-2.0-1.71.2
Fe content in liver0.50.60.9-0.7-0.8-0.80.8-0.8-0.9-0.7
K content in liver0.50.51.0-0.6-0.6-0.60.6-0.6-1.0-0.7
Mg content in liver0.00.00.00.20.20.2-0.20.20.10.1
Mn content in liver1.82.12.6-1.4-1.6-1.61.6-1.6-1.50.5
Na content in liver0.20.20.40.60.50.5-0.50.50.40.3
Rb content in liver0.91.21.41.21.01.1-1.11.11.2-0.7
Se content in liver0.60.71.2-0.7-0.8-0.90.9-0.9-0.61.1
Sr content in liver1.31.21.31.11.11.1-1.11.11.0-1.1
Zn content in liver0.10.10.3-0.5-0.3-0.30.3-0.3-0.00.5
Bone: minimum diameter2.14.04.82.12.12.2-2.22.21.9-1.1
Time in familiar zone, hab. session 10.30.30.50.60.50.6-0.60.60.70.3
Time in novel zone, hab. session 10.60.60.8-0.8-0.8-0.80.8-0.8-0.9-0.0
Total zone transitions, hab. session 15.57.710.13.22.82.9-2.92.92.8-1.7
Total locomotion distance, hab. session 10.30.40.60.80.60.6-0.60.60.5-0.7
Locomotion velocity, hab. session 10.50.70.91.00.80.8-0.80.80.8-0.6
Time in familiar zone, hab. session 20.30.40.6-0.8-0.7-0.60.6-0.6-0.6-0.1
Time in novel zone, hab. session 20.10.10.7-0.0-0.1-0.10.1-0.1-0.10.8
Total zone transitions, hab. session 22.12.73.11.51.61.7-1.71.71.4-1.8
Total locomotion distance, hab. session 20.40.50.70.60.60.7-0.70.70.4-0.8
Locomotion velocity, hab. session 20.40.60.70.70.70.9-0.90.90.5-0.8
Novel to familiar place preference ratio0.20.20.30.30.50.4-0.40.40.60.3
Novelty place preference0.00.00.0-0.10.10.1-0.10.10.10.2
Time in novel zone, NPP test0.00.00.1-0.2-0.0-0.10.1-0.1-0.00.0
Total zone transitions, NPP test3.14.45.12.12.12.3-2.32.32.0-1.7
Total locomotion distance, NPP test0.50.70.90.80.91.0-1.01.00.9-0.0
Locomotion velocity, NPP test0.60.81.00.80.91.0-1.01.01.00.4
Intraocular pressure3.14.36.32.32.02.2-2.22.22.50.0
Delta distance traveled before/after self-admin2.12.34.21.61.61.4-1.41.41.0-2.0
Delta ambulatory time before/after self-admin1.21.32.51.31.21.0-1.01.00.7-1.6
Parametrial fat weight5.210.230.32.72.62.8-2.82.81.8-5.5
Pavlov. Cond. lever latency2.63.34.41.62.12.0-2.02.01.9-0.7
Pavlov. Cond. magazine entry latency4.45.77.6-2.3-2.8-2.62.6-2.6-2.50.5
Pavlov. Cond. change in total contacts1.71.82.4-1.1-1.5-1.41.4-1.4-1.21.2
Pavlov. Cond. index score3.24.05.6-1.9-2.4-2.22.2-2.2-2.20.3
Pavlov. Cond. latency score3.74.76.4-2.1-2.5-2.42.4-2.4-2.40.2
Pavlov. Cond. lever contacts2.12.43.5-1.5-1.9-1.71.7-1.7-1.70.4
Pavlov. Cond. magazine entry number2.02.43.71.41.91.7-1.71.71.5-0.6
Pavlov. Cond. intertrial magazine entries3.54.25.32.02.32.2-2.22.22.2-0.9
Pavlov. Cond. lever-magazine prob. diff.2.93.65.1-1.8-2.3-2.02.0-2.0-2.00.4
Pavlov. Cond. response bias2.63.14.6-1.7-2.1-1.91.9-1.9-1.80.5
Pavlov. Cond. lever latency0.60.83.00.50.70.7-0.70.70.5-1.7
Pavlov. Cond. magazine entry latency0.80.91.1-0.9-1.0-1.01.0-1.0-0.91.1
Pavlov. Cond. change in total contacts0.40.61.2-0.6-0.7-0.80.8-0.8-0.71.1
Pavlov. Cond. index score0.30.42.6-0.1-0.2-0.20.2-0.2-0.11.6
Pavlov. Cond. latency score0.40.53.3-0.0-0.1-0.10.1-0.10.01.8
Pavlov. Cond. lever contacts0.20.21.2-0.0-0.3-0.30.3-0.3-0.21.1
Pavlov. Cond. magazine entry number0.30.41.30.40.50.5-0.50.50.4-1.1
Pavlov. Cond. intertrial magazine entries0.50.61.50.80.60.6-0.60.60.6-1.2
Pavlov. Cond. lever-magazine prob. diff.0.30.42.7-0.1-0.3-0.30.3-0.3-0.11.6
Pavlov. Cond. response bias0.30.51.5-0.4-0.6-0.60.6-0.6-0.51.2
Time in closed arm before self-admin2.22.53.5-1.8-1.5-1.61.6-1.6-1.9-0.6
Time in closed arm after self-admin0.10.10.3-0.3-0.3-0.30.3-0.3-0.50.2
Time in open arm before self-admin0.50.62.80.50.20.4-0.40.40.61.7
Time in open arm after self-admin1.71.93.01.51.51.3-1.31.31.70.3
Bone: periosteal estimation1.94.04.92.12.22.2-2.22.22.0-0.5
Bone: periosteal perimeter1.32.22.81.71.61.6-1.61.61.5-0.3
Bone: post-yield work0.10.21.20.10.10.0-0.00.0-0.2-1.1
Progressive ratio test 1 active lever presses0.91.02.01.11.10.8-0.80.80.8-1.4
Progressive ratio test 1 breakpoint1.11.23.51.11.00.8-0.80.80.8-1.9
Progressive ratio test 1 inactive lever presses1.21.32.51.31.61.0-1.01.01.2-0.6
Progressive ratio test 2 active lever presses0.60.71.11.00.80.7-0.70.70.9-1.0
Progressive ratio test 2 breakpoint0.30.30.60.70.50.4-0.40.40.6-0.8
Progressive ratio test 2 inactive lever presses2.12.43.21.81.71.5-1.51.51.6-1.0
Incentive Sensitization - Responses0.00.00.2-0.0-0.0-0.00.0-0.00.1-0.5
Incentive Sensitization - Breakpoint0.00.00.20.00.00.0-0.00.00.1-0.4
Sum of active levers in priming session hrs 5-61.11.02.1-1.1-0.7-0.90.9-0.9-1.0-1.5
Progressive ratio1.11.32.41.61.31.1-1.11.11.1-0.4
Food seeking constrained by brief footshock0.00.10.3-0.0-0.20.0-0.00.0-0.10.5
Seeking ratio, punishment vs. effort1.41.73.0-1.7-1.4-1.21.2-1.2-1.40.9
Retroperitoneal fat weight0.31.11.71.31.01.1-1.11.11.20.1
Reaction time number correct0.20.20.6-0.8-0.4-0.40.4-0.4-0.5-0.2
Reaction time mean minus median0.20.21.2-0.1-0.3-0.20.2-0.20.11.1
Reaction time mean minus median AUC0.10.10.20.3-0.00.1-0.10.10.40.5
Reaction time num false alarms0.50.61.9-0.8-0.9-0.70.7-0.7-0.31.4
Reaction time num false alarms AUC0.30.51.8-0.6-0.7-0.50.5-0.5-0.21.3
Reaction time trials correct on left0.20.20.6-0.8-0.4-0.40.4-0.4-0.5-0.2
Reaction time trials on left0.10.20.6-0.7-0.4-0.40.4-0.4-0.5-0.1
Reaction time mean0.10.10.5-0.0-0.3-0.10.1-0.10.10.7
Reaction time mean AUC0.10.21.2-0.0-0.3-0.10.1-0.10.11.1
Median of all reaction times0.00.10.20.2-0.10.1-0.10.10.20.5
Reaction time omissions0.60.81.21.10.71.0-1.01.01.0-0.4
Reaction time false alarm rate0.20.31.3-0.2-0.5-0.30.3-0.30.01.1
Reaction time premature initiation rate2.83.84.7-2.0-2.0-2.22.2-2.2-2.00.5
Reaction time premature initiations2.73.84.9-2.2-2.0-2.22.2-2.2-2.00.4
Std. dev. reaction times0.50.62.1-0.5-0.8-0.70.7-0.7-0.31.4
Reaction time trials completed0.10.20.6-0.7-0.4-0.40.4-0.4-0.5-0.1
Reaction time trials AUC0.20.20.6-0.8-0.4-0.40.4-0.4-0.5-0.1
Run reversals in cocaine runway, females0.10.10.4-0.2-0.1-0.20.2-0.2-0.10.6
Run reversals in cocaine runway, males2.92.83.91.61.81.8-1.81.82.00.1
Latency to leave start box in cocaine runway0.00.00.1-0.1-0.3-0.10.1-0.1-0.20.0
Latency to leave start box in cocaine runway, F0.20.20.4-0.1-0.6-0.30.3-0.3-0.6-0.4
Latency to leave start box in cocaine runway, M0.20.20.30.10.50.5-0.50.50.4-0.3
Std. dev. time between licks in bursts0.20.20.80.20.40.4-0.40.40.2-0.9
Total sessions with >9 infusions2.72.94.62.12.01.5-1.51.51.6-1.5
Short access day 1 total inactive lever presses0.10.10.4-0.20.6-0.20.2-0.20.1-0.3
Short access day 10 total inactive lever presses0.60.71.0-1.0-0.5-0.90.9-0.9-0.80.3
Short access day 1 total infusions5.25.57.92.52.82.4-2.42.42.6-0.6
Short access day 10 total infusions2.02.23.01.71.61.4-1.41.41.6-1.0
Short access total infusions5.66.38.12.82.82.6-2.62.62.7-1.1
Short access day 1 locomotion2.02.23.21.81.71.4-1.41.41.8-0.0
Short access day 10 total locomotion0.60.61.90.81.40.6-0.60.60.90.0
Short access total locomotion0.80.82.01.01.40.8-0.80.81.0-0.0
One hour access (0.3 mA shock)2.02.34.12.01.51.4-1.41.41.6-1.1
Compulsive drug intake2.82.93.7-1.8-1.5-1.91.9-1.9-1.80.1
One hour access (shock baseline)3.64.25.52.32.02.1-2.12.12.2-1.0
Social response proportion4.04.46.0-1.9-2.2-2.32.3-2.3-2.4-1.1
Social responses0.70.95.00.40.40.5-0.50.50.1-2.2
Social time0.30.42.70.10.10.1-0.10.1-0.2-1.6
Soleus weight0.72.013.30.40.40.3-0.30.3-0.3-3.6
Bone: stiffness0.61.04.60.70.70.7-0.70.70.1-2.2
Tibialis anterior weight1.96.414.22.62.32.2-2.22.21.9-3.8
Time to tail flick, vehicle, before self-admin0.70.81.4-0.9-0.7-0.80.8-0.8-0.9-1.2
Time to tail flick, vehicle, after self-admin0.10.20.20.50.30.5-0.50.50.4-0.0
Time to tail flick, test, before self-admin5.85.66.6-2.4-2.5-2.62.6-2.6-2.60.9
Time to tail flick, test, after self-admin1.41.52.3-1.5-1.2-1.21.2-1.2-1.30.3
Delta time to tail flick, vehicle, before/after SA1.91.92.51.51.41.4-1.41.41.60.7
Delta time to tail flick, test, before/after SA2.52.22.81.41.61.6-1.61.61.7-0.6
Tibia length1.23.45.5-1.9-1.9-1.91.9-1.9-2.3-0.7
Ambulatory time before self-admin0.40.40.50.50.70.7-0.70.70.70.3
Ambulatory time after self-admin2.22.53.31.81.71.6-1.61.61.1-1.6
Bone: tissue strength0.30.30.30.50.50.5-0.50.50.50.4
Total heroin consumption2.32.74.8-1.5-1.2-1.61.6-1.6-1.7-2.2
Bone: trabecular number0.71.21.4-1.2-1.1-1.11.1-1.1-1.2-0.9
Bone: trabecular spacing0.60.71.31.00.80.8-0.80.81.10.5
Bone: trabecular thickness0.10.10.4-0.3-0.1-0.10.1-0.1-0.5-0.7
Bone: trabecular tissue density0.50.83.5-0.5-0.6-0.60.6-0.6-0.41.9
Water consumed over 24 hours4.85.76.8-2.4-2.6-2.62.6-2.6-2.50.9
Number of responses in last shaping day1.31.32.31.11.51.0-1.01.01.40.6