Hub : Genes

Osr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	alternative TSS	NM_001106716.3	0.02	0.02	5.1e-03	0.03	0.02	0.02	0.02	2.0e-03	2.3e-03	3.2e-03	3.4e-03
2	Brain	isoform ratio	XM_039111941.2	0.03	0.02	4.0e-03	0.03	0.03	0.03	0.03	1.0e-03	1.7e-03	1.4e-03	2.1e-03
3	Brain	alternative TSS	NM_001106716.3	0.02	0.02	6.6e-03	0.03	0.02	0.02	0.02	1.3e-03	3.3e-03	3.4e-03	2.9e-03
4	Brain	intron excision ratio	chr6_38093287_38097653	0.05	0.03	9.5e-04	0.04	0.02	0.04	0.03	8.4e-05	2.3e-03	2.7e-04	4.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.3	2.2	6.1	-1.0	1.0	-1.0	-2.5
Area under the delay curve	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.2
BMI with tail	0.4	1.5	2.7	1.0	-1.0	1.0	-1.7
BMI without tail	0.9	2.8	3.7	1.9	-1.9	1.9	-0.4
Body weight	0.6	2.5	2.8	1.7	-1.7	1.7	-1.2
Weight adjusted by age	0.5	0.8	1.0	-0.9	0.9	-0.9	1.0
Bone surface	2.2	4.0	10.1	-1.4	1.4	-1.4	-3.2
Bone volume	2.3	4.0	11.9	-1.2	1.2	-1.2	-3.4
Breakpoint value in progressive ratio session	0.5	0.6	0.7	0.9	-0.9	0.9	-0.1
Number of licking bursts	0.1	0.2	0.6	0.0	-0.0	0.0	0.8
Context. condit. distance diff. score	0.1	0.2	0.2	0.4	-0.4	0.4	0.0
Locomotion velocity, session 1	0.4	0.5	0.5	0.7	-0.7	0.7	-0.7
Locomotion distance, session 1	0.4	0.6	2.2	-0.1	0.1	-0.1	1.5
Locomotion velocity, session 2	0.5	0.6	0.7	0.9	-0.9	0.9	0.3
Locomotion distance, session 2	0.3	0.5	0.6	0.8	-0.8	0.8	0.2
Locomotion velocity, session 3	0.0	0.1	0.2	0.0	-0.0	0.0	-0.5
Locomotion distance, session 3	0.9	1.0	1.0	1.0	-1.0	1.0	1.0
Stereotopy head waving bouts, day 3	1.3	1.5	1.9	-1.2	1.2	-1.2	-1.4
Stereotopy head waving duration, day 3	1.6	1.9	3.4	-1.2	1.2	-1.2	-1.8
Locomotion velocity, session 7	0.5	0.6	0.6	0.8	-0.8	0.8	0.7
Locomotion distance, session 7	0.4	0.5	0.6	0.8	-0.8	0.8	0.4
Stereotopy head waving bouts, day 7	1.7	2.0	2.1	-1.5	1.5	-1.5	-1.2
Stereotopy head waving duration, day 7	2.6	3.2	3.6	-1.9	1.9	-1.9	-1.3
Locomotion velocity, session 8	3.4	4.1	5.5	2.3	-2.3	2.3	0.1
Locomotion distance, session 8	0.9	1.3	1.6	1.3	-1.3	1.3	0.7
Degree of sensitization distance	0.0	0.0	0.0	0.0	-0.0	0.0	-0.0
Degree of sensitization stereotypy	1.0	1.1	1.4	-1.2	1.2	-1.2	-0.4
Conditioned locomotion	0.1	0.1	0.3	0.2	-0.2	0.2	0.6
Cocaine response after cond. corrected	0.3	0.3	0.4	-0.7	0.7	-0.7	-0.1
Cocaine response after cond. not corrected	1.1	1.2	1.7	-1.3	1.3	-1.3	-0.0
Cocaine response before conditioning	2.5	3.0	3.8	-2.0	2.0	-2.0	-0.7
Saline control response	0.5	0.6	0.6	-0.8	0.8	-0.8	-0.8
Bone: connectivity density	1.4	2.2	5.3	-1.1	1.1	-1.1	-2.3
Bone: cortical apparent density	1.6	2.3	2.7	1.6	-1.6	1.6	-1.0
Bone: cortical area	1.0	1.6	2.8	-1.1	1.1	-1.1	-1.7
Bone: cortical porosity	4.3	4.7	5.8	-2.4	2.4	-2.4	-1.2
Bone: cortical porosity	3.4	3.7	4.4	-2.1	2.1	-2.1	-1.2
Bone: cortical thickness	0.5	0.8	2.2	-0.6	0.6	-0.6	-1.5
Bone: cortical thickness	0.1	0.2	0.3	-0.3	0.3	-0.3	-0.6
Bone: cortical tissue density	2.1	2.8	3.4	1.9	-1.9	1.9	-0.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.3	-0.3	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.8	0.9	-0.9	0.9	0.1
Condit. Reinf. active responses	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.3
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.4
Incentive salience index mean	0.0	0.0	0.0	0.2	-0.2	0.2	0.1
Condit. Reinf. lever presses	0.2	0.3	0.4	-0.6	0.6	-0.6	0.4
Condit. Reinf. active minus inactive responses	0.4	0.6	0.8	-0.7	0.7	-0.7	-0.9
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.0	-1.0	1.0	-1.0	0.0
Condit. Reinf. active responses	0.2	0.3	0.6	0.4	-0.4	0.4	-0.8
Condit. Reinf. inactive responses	0.7	0.9	0.9	1.0	-1.0	1.0	-0.8
Condit. Reinf. lever presses	0.2	0.2	0.3	-0.6	0.6	-0.6	-0.0
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	0.3	-0.3	0.3	-0.6
Conditioned reinforcement - actives	0.1	0.1	0.2	0.4	-0.4	0.4	0.3
Conditioned reinforcement - inactives	0.1	0.2	0.2	-0.5	0.5	-0.5	-0.1
Conditioned locomotion	0.0	0.0	0.0	0.1	-0.1	0.1	-0.2
Patch foraging indifference point 0 sec	0.5	0.9	3.5	0.1	-0.1	0.1	1.9
Patch foraging indifference point AUC	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.3
Delay disc. indifference point, 0s delay	0.4	0.4	0.5	-0.7	0.7	-0.7	0.2
Delay disc. indifference point, 16s delay	1.1	1.2	1.8	1.0	-1.0	1.0	1.4
Delay disc. indifference point, 2s delay	0.5	0.5	1.9	-0.3	0.3	-0.3	-1.4
Delay disc. indifference point, 24s delay	0.4	0.4	0.5	0.6	-0.6	0.6	0.7
Delay disc. indifference point, 4s delay	1.0	1.1	1.3	-1.1	1.1	-1.1	-0.7
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	0.3	-0.3	0.3	0.4
Indifference point function ln k	0.3	0.5	0.5	-0.7	0.7	-0.7	-0.7
Indifference point function log k	0.3	0.5	0.5	-0.7	0.7	-0.7	-0.7
Patch foraging total patch changes 0 sec	0.4	0.8	3.1	-0.2	0.2	-0.2	1.8
Patch foraging total patch changes 12 sec	0.1	0.2	0.4	-0.3	0.3	-0.3	0.6
Patch foraging total patch changes 18 sec	0.7	1.1	1.2	-1.1	1.1	-1.1	0.8
Patch foraging total patch changes 24 sec	0.4	0.6	0.9	-0.7	0.7	-0.7	1.0
Patch foraging total patch changes 6 sec	1.1	1.6	2.6	-1.2	1.2	-1.2	1.6
Patch foraging time to switch 0 sec	0.6	1.3	1.6	1.3	-1.3	1.3	0.3
Patch foraging water rate 0 sec	0.7	1.5	2.0	-1.4	1.4	-1.4	-0.2
Patch foraging water rate 12 sec	0.1	0.2	0.2	-0.4	0.4	-0.4	0.5
Patch foraging water rate 18 sec	2.6	4.1	5.3	-2.3	2.3	-2.3	0.8
Patch foraging water rate 24 sec	0.1	0.1	0.5	0.0	-0.0	0.0	0.7
Patch foraging water rate 6 sec	0.5	0.7	1.3	-0.7	0.7	-0.7	-1.1
Seeking ratio, delayed vs. immediate footshock	5.8	7.1	7.8	-2.8	2.8	-2.8	-2.3
Distance traveled before self-admin	0.8	1.1	2.1	0.9	-0.9	0.9	1.4
Distance traveled after self-admin	0.8	1.0	1.2	-1.1	1.1	-1.1	0.7
Extensor digitorum longus weight	0.2	0.6	2.1	0.3	-0.3	0.3	-1.4
Bone: elastic displacement	0.0	0.0	0.1	0.0	-0.0	0.0	0.3
Bone: elastic work	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.1
Bone: endosteal estimation	0.1	0.3	1.2	-0.1	0.1	-0.1	-1.1
Bone: endosteal perimeter	0.2	0.5	0.6	-0.7	0.7	-0.7	-0.8
Epididymis fat weight	3.5	11.8	12.6	3.6	-3.6	3.6	3.1
Delta time in closed arm before/after self-admin	0.5	0.5	0.6	0.8	-0.8	0.8	-0.2
Delta time in open arm before/after self-admin	2.1	2.1	2.8	1.7	-1.7	1.7	0.0
Diff in mean of infusions in LGA sessions	1.1	1.3	4.6	0.5	-0.5	0.5	-2.2
Delay discount exponential model param	0.0	0.0	0.1	0.1	-0.1	0.1	0.3
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.4	0.4	-0.4	0.1
Active lever presses in extinction session 6	0.2	0.2	0.2	-0.5	0.5	-0.5	-0.5
Bone: final force	1.0	1.5	3.7	-0.9	0.9	-0.9	-1.9
Bone: final moment	1.0	1.7	4.9	-0.8	0.8	-0.8	-2.2
Food consumed during 24 hour testing period	1.0	1.3	2.0	-1.1	1.1	-1.1	-1.4
Glucose	1.4	2.2	2.7	1.7	-1.7	1.7	-0.7
Heart weight	1.6	2.5	3.3	-1.5	1.5	-1.5	-1.8
Delay discount hyperbolic model param	0.1	0.1	0.4	0.2	-0.2	0.2	0.6
Intermittent access intake day 1-15 change	0.5	1.0	1.3	1.1	-1.1	1.1	0.6
Intermittent access intake escalation	0.5	1.1	1.2	1.1	-1.1	1.1	0.8
Intermittent access intake escalation 2	1.7	1.9	2.3	1.3	-1.3	1.3	1.5
Intermitt. access day 1 inactive lever presses	0.2	0.9	1.2	-1.1	1.1	-1.1	-0.1
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.2	-0.4	0.4	-0.4	0.5
Intermitt. access escalation Index	0.3	0.5	1.9	-0.1	0.1	-0.1	-1.4
Intermittent access day 1 total infusions	0.2	0.4	0.9	-0.4	0.4	-0.4	0.9
Intermittent access day 15 total infusions	1.5	2.2	2.2	1.5	-1.5	1.5	1.5
Intermittent access terminal intake (last 3 days)	1.1	1.4	2.7	1.0	-1.0	1.0	1.6
Intermittent access total infusions	0.4	0.5	1.6	0.3	-0.3	0.3	1.3
Intermittent access day 1 locomotion	0.4	0.5	0.5	-0.7	0.7	-0.7	-0.5
Intermittent access day 15 total locomotion	0.4	0.7	2.8	0.2	-0.2	0.2	-1.7
Intermittent access total locomotion	0.1	0.1	0.1	0.3	-0.3	0.3	-0.3
Intermittent access standard deviation	0.6	1.2	3.8	0.6	-0.6	0.6	1.9
Left kidney weight	0.1	0.7	2.6	0.0	-0.0	0.0	-1.6
Right kidney weight	0.1	0.4	1.2	-0.4	0.4	-0.4	-1.1
Cocaine induced anxiety	1.3	1.8	2.3	1.5	-1.5	1.5	0.8
Post-drug Anxiety	0.7	0.7	0.9	0.8	-0.8	0.8	0.9
Baseline Anxiety	0.3	0.4	0.4	-0.7	0.7	-0.7	-0.3
Tail length	0.2	0.9	1.1	1.1	-1.1	1.1	0.6
Length with tail	0.0	0.1	0.1	0.4	-0.4	0.4	-0.2
Length without tail	0.4	1.4	1.8	-1.3	1.3	-1.3	-0.4
Times rat made contact with spout	1.2	1.4	1.8	-1.4	1.4	-1.4	0.1
Lifetime Intake	0.4	0.5	2.1	-0.1	0.1	-0.1	1.5
Liver weight, left	2.6	4.2	5.1	2.3	-2.3	2.3	1.2
Liver weight, right	0.5	0.9	2.5	0.6	-0.6	0.6	1.6
Locomotor activity	0.2	0.3	1.0	0.1	-0.1	0.1	1.0
Locomotor testing distance	0.1	0.2	0.4	-0.3	0.3	-0.3	0.6
Locomotor testing rearing	1.0	1.9	2.5	-1.6	1.6	-1.6	-0.4
Locomotion in novel chamber	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.0
Locomotion in novel chamber post-restriction	0.3	0.4	0.6	-0.7	0.7	-0.7	0.2
Fecal boli incidents, locomotor time 1	0.5	0.8	2.8	-0.3	0.3	-0.3	1.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.0
Time >=10cm from walls, locomotor time 1	1.2	1.2	1.5	1.2	-1.2	1.2	0.6
Bouts of movement, locomotor time 1	2.8	3.2	4.2	-2.0	2.0	-2.0	0.5
Total resting periods, locomotor time 1	3.0	3.3	4.4	-2.1	2.1	-2.1	0.1
Rest time, locomotor task time 1	0.2	0.2	0.4	-0.4	0.4	-0.4	0.7
Distance moved, locomotor task time 1	1.8	2.8	3.6	1.9	-1.9	1.9	0.4
Vertical activity count, locomotor time 1	0.3	0.8	1.1	1.0	-1.0	1.0	-0.4
Time >=10cm from walls, locomotor time 2	0.5	0.8	2.8	0.3	-0.3	0.3	-1.7
Bouts of movement, locomotor time 2	0.8	1.3	1.6	-1.3	1.3	-1.3	0.4
Total resting periods, locomotor time 2	1.1	1.9	2.6	-1.6	1.6	-1.6	0.3
Rest time, locomotor task time 2	0.2	0.2	0.7	0.2	-0.2	0.2	0.9
Distance moved, locomotor task time 2	0.1	0.2	0.3	0.4	-0.4	0.4	0.5
Vertical activity count, locomotor time 2	0.0	0.0	0.0	0.2	-0.2	0.2	0.0
Light reinforcement 1	0.2	0.5	0.7	-0.8	0.8	-0.8	0.2
Light reinforcement 2	0.7	1.0	1.2	-1.1	1.1	-1.1	-0.7
Bone: marrow area	0.1	0.3	1.2	-0.1	0.1	-0.1	-1.1
Bone: maximum diameter	1.1	2.1	2.4	-1.4	1.4	-1.4	-1.5
Bone: maximum force	1.1	1.9	3.7	-1.2	1.2	-1.2	-1.9
Bone: maximum moment	1.0	1.8	4.3	-1.0	1.0	-1.0	-2.1
Mean time between licks in bursts	0.2	0.5	0.7	0.8	-0.8	0.8	0.2
Mean num. licks in bursts	0.3	0.4	0.5	-0.7	0.7	-0.7	-0.3
Cd content in liver	0.2	0.2	0.2	0.5	-0.5	0.5	-0.3
Co content in liver	0.4	0.5	0.5	-0.7	0.7	-0.7	0.6
Cu content in liver	2.0	2.3	3.1	1.8	-1.8	1.8	0.0
Fe content in liver	0.9	1.1	1.3	-1.0	1.0	-1.0	-1.1
K content in liver	0.2	0.2	0.4	0.3	-0.3	0.3	-0.7
Mg content in liver	0.1	0.1	0.1	-0.4	0.4	-0.4	0.0
Mn content in liver	0.2	0.3	1.0	0.1	-0.1	0.1	-1.0
Na content in liver	0.8	0.8	1.1	-1.1	1.1	-1.1	-0.1
Rb content in liver	1.5	1.7	1.8	-1.3	1.3	-1.3	-1.4
Se content in liver	0.0	0.0	0.0	0.0	-0.0	0.0	0.2
Sr content in liver	1.5	1.3	2.2	1.0	-1.0	1.0	1.5
Zn content in liver	0.2	0.3	0.3	0.5	-0.5	0.5	-0.5
Bone: minimum diameter	0.2	0.3	0.6	0.4	-0.4	0.4	-0.8
Time in familiar zone, hab. session 1	0.3	0.3	1.3	0.2	-0.2	0.2	1.1
Time in novel zone, hab. session 1	0.4	0.4	0.9	-0.5	0.5	-0.5	-0.9
Total zone transitions, hab. session 1	1.3	1.8	2.2	-1.5	1.5	-1.5	0.6
Total locomotion distance, hab. session 1	0.6	0.9	2.0	-0.7	0.7	-0.7	1.4
Locomotion velocity, hab. session 1	0.5	0.7	0.7	-0.8	0.8	-0.8	0.7
Time in familiar zone, hab. session 2	0.2	0.2	0.2	-0.4	0.4	-0.4	-0.4
Time in novel zone, hab. session 2	0.9	0.9	1.2	1.1	-1.1	1.1	-0.1
Total zone transitions, hab. session 2	1.0	1.3	2.1	-1.0	1.0	-1.0	1.5
Total locomotion distance, hab. session 2	1.0	1.4	4.1	-0.7	0.7	-0.7	2.0
Locomotion velocity, hab. session 2	1.1	1.4	4.7	-0.6	0.6	-0.6	2.2
Novel to familiar place preference ratio	0.5	0.5	1.1	0.6	-0.6	0.6	-1.0
Novelty place preference	0.6	0.6	1.4	0.6	-0.6	0.6	-1.2
Time in novel zone, NPP test	0.4	0.4	1.1	0.5	-0.5	0.5	-1.0
Total zone transitions, NPP test	0.5	0.8	3.0	-0.0	0.0	-0.0	1.7
Total locomotion distance, NPP test	0.7	0.9	3.3	0.3	-0.3	0.3	1.8
Locomotion velocity, NPP test	0.5	0.7	2.6	0.2	-0.2	0.2	1.6
Intraocular pressure	0.2	0.3	0.4	0.6	-0.6	0.6	0.5
Delta distance traveled before/after self-admin	3.3	3.5	3.8	-1.9	1.9	-1.9	-1.7
Delta ambulatory time before/after self-admin	2.6	3.3	3.9	-1.7	1.7	-1.7	-2.0
Parametrial fat weight	0.7	1.6	2.0	1.4	-1.4	1.4	0.7
Pavlov. Cond. lever latency	1.3	1.6	2.2	1.5	-1.5	1.5	-0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.6	-0.6	0.6	-0.6	0.8
Pavlov. Cond. change in total contacts	3.0	3.2	4.0	-2.0	2.0	-2.0	0.9
Pavlov. Cond. index score	1.4	1.8	2.3	-1.5	1.5	-1.5	0.2
Pavlov. Cond. latency score	1.2	1.5	2.0	-1.4	1.4	-1.4	0.1
Pavlov. Cond. lever contacts	1.3	1.5	2.0	-1.4	1.4	-1.4	0.3
Pavlov. Cond. magazine entry number	1.0	1.2	1.6	1.3	-1.3	1.3	-0.2
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.4	1.2	-1.2	1.2	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	2.4	-1.5	1.5	-1.5	0.2
Pavlov. Cond. response bias	1.8	2.3	2.9	-1.7	1.7	-1.7	0.6
Pavlov. Cond. lever latency	0.7	0.9	1.2	1.1	-1.1	1.1	0.3
Pavlov. Cond. magazine entry latency	3.7	4.5	8.5	-1.8	1.8	-1.8	-2.9
Pavlov. Cond. change in total contacts	2.5	3.9	4.9	-2.2	2.2	-2.2	-1.1
Pavlov. Cond. index score	3.2	4.3	4.9	-2.2	2.2	-2.2	-1.7
Pavlov. Cond. latency score	3.3	4.3	4.9	-2.2	2.2	-2.2	-1.6
Pavlov. Cond. lever contacts	0.7	1.0	1.2	-1.1	1.1	-1.1	-0.5
Pavlov. Cond. magazine entry number	2.3	2.8	4.3	1.5	-1.5	1.5	2.1
Pavlov. Cond. intertrial magazine entries	1.9	2.9	3.5	1.9	-1.9	1.9	1.0
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.8	5.3	-2.3	2.3	-2.3	-1.8
Pavlov. Cond. response bias	1.4	1.8	2.0	-1.3	1.3	-1.3	-1.4
Time in closed arm before self-admin	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.1
Time in closed arm after self-admin	0.3	0.3	0.7	0.4	-0.4	0.4	0.8
Time in open arm before self-admin	0.1	0.1	0.4	-0.2	0.2	-0.2	0.6
Time in open arm after self-admin	0.2	0.2	0.4	0.4	-0.4	0.4	-0.6
Bone: periosteal estimation	0.5	1.0	2.8	-0.6	0.6	-0.6	-1.7
Bone: periosteal perimeter	0.3	0.6	1.0	-0.6	0.6	-0.6	-1.0
Bone: post-yield work	0.2	0.2	0.9	-0.1	0.1	-0.1	-0.9
Progressive ratio test 1 active lever presses	0.4	0.5	1.2	-0.5	0.5	-0.5	1.1
Progressive ratio test 1 breakpoint	0.4	0.5	1.3	-0.5	0.5	-0.5	1.1
Progressive ratio test 1 inactive lever presses	0.8	1.2	1.4	-1.2	1.2	-1.2	0.6
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	0.3	-0.3	0.3	0.4
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	0.3	-0.3	0.3	0.4
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	-0.4	0.4	-0.4	0.6
Incentive Sensitization - Responses	0.9	1.2	1.3	1.1	-1.1	1.1	-1.1
Incentive Sensitization - Breakpoint	0.9	1.2	1.6	1.0	-1.0	1.0	-1.3
Sum of active levers in priming session hrs 5-6	0.6	0.6	0.7	0.9	-0.9	0.9	0.1
Progressive ratio	1.8	2.9	5.7	-1.4	1.4	-1.4	-2.4
Food seeking constrained by brief footshock	1.4	1.8	2.3	-1.5	1.5	-1.5	0.4
Seeking ratio, punishment vs. effort	1.0	1.5	5.9	-0.1	0.1	-0.1	2.4
Retroperitoneal fat weight	6.4	27.4	36.5	6.0	-6.0	6.0	0.2
Reaction time number correct	0.3	0.5	1.4	0.4	-0.4	0.4	-1.2
Reaction time mean minus median	0.6	1.5	1.9	1.4	-1.4	1.4	-0.0
Reaction time mean minus median AUC	0.1	0.2	0.3	0.4	-0.4	0.4	-0.6
Reaction time num false alarms	0.0	0.0	0.0	0.1	-0.1	0.1	0.1
Reaction time num false alarms AUC	0.0	0.1	0.1	0.3	-0.3	0.3	0.1
Reaction time trials correct on left	0.3	0.5	1.4	0.4	-0.4	0.4	-1.2
Reaction time trials on left	0.3	0.5	1.4	0.5	-0.5	0.5	-1.2
Reaction time mean	0.6	0.9	1.2	1.1	-1.1	1.1	0.5
Reaction time mean AUC	0.7	1.1	1.4	1.2	-1.2	1.2	0.6
Median of all reaction times	0.6	0.8	1.0	1.0	-1.0	1.0	0.5
Reaction time omissions	1.6	2.3	3.0	1.7	-1.7	1.7	0.1
Reaction time false alarm rate	0.1	0.1	0.4	-0.0	0.0	-0.0	0.6
Reaction time premature initiation rate	0.8	1.1	1.2	-1.0	1.0	-1.0	1.1
Reaction time premature initiations	0.2	0.3	0.3	-0.6	0.6	-0.6	0.4
Std. dev. reaction times	0.7	1.3	1.7	1.3	-1.3	1.3	-0.0
Reaction time trials completed	0.3	0.5	1.4	0.5	-0.5	0.5	-1.2
Reaction time trials AUC	0.2	0.5	1.4	0.4	-0.4	0.4	-1.2
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.4	0.4	-0.4	-0.2
Run reversals in cocaine runway, males	2.2	2.3	4.3	-1.3	1.3	-1.3	2.1
Latency to leave start box in cocaine runway	0.5	0.5	0.7	0.8	-0.8	0.8	-0.2
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	0.1	-0.1	0.1	0.0
Latency to leave start box in cocaine runway, M	1.0	0.9	1.1	1.1	-1.1	1.1	-0.4
Std. dev. time between licks in bursts	0.8	1.1	1.5	1.2	-1.2	1.2	0.3
Total sessions with >9 infusions	0.5	0.6	0.7	-0.8	0.8	-0.8	0.4
Short access day 1 total inactive lever presses	0.8	1.1	1.4	-1.2	1.2	-1.2	0.5
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.2	-0.2	0.2	0.2
Short access day 1 total infusions	0.5	0.6	0.6	-0.8	0.8	-0.8	0.7
Short access day 10 total infusions	0.5	0.7	2.6	0.3	-0.3	0.3	1.6
Short access total infusions	0.3	0.3	1.3	-0.1	0.1	-0.1	1.1
Short access day 1 locomotion	1.2	1.5	1.6	-1.3	1.3	-1.3	-1.0
Short access day 10 total locomotion	0.1	0.1	0.1	0.4	-0.4	0.4	-0.2
Short access total locomotion	0.2	0.3	0.5	-0.5	0.5	-0.5	-0.7
One hour access (0.3 mA shock)	1.3	1.6	4.0	0.9	-0.9	0.9	2.0
Compulsive drug intake	0.3	0.4	0.5	-0.7	0.7	-0.7	-0.3
One hour access (shock baseline)	0.7	1.0	2.1	0.8	-0.8	0.8	1.5
Social response proportion	0.4	0.4	0.5	0.7	-0.7	0.7	-0.4
Social responses	0.6	0.8	0.9	1.0	-1.0	1.0	-0.5
Social time	0.1	0.1	0.4	0.2	-0.2	0.2	-0.6
Soleus weight	3.5	10.3	12.5	-3.5	3.5	-3.5	-1.9
Bone: stiffness	2.1	3.4	6.1	-1.6	1.6	-1.6	-2.5
Tibialis anterior weight	0.0	0.1	0.1	0.3	-0.3	0.3	0.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.9	-0.1	0.1	-0.1	-1.0
Time to tail flick, vehicle, after self-admin	2.3	3.1	4.1	2.0	-2.0	2.0	0.3
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.3	0.3	-0.3	0.4
Time to tail flick, test, after self-admin	0.2	0.2	1.0	-0.1	0.1	-0.1	-1.0
Delta time to tail flick, vehicle, before/after SA	2.0	1.9	2.5	1.6	-1.6	1.6	0.5
Delta time to tail flick, test, before/after SA	1.1	1.1	2.2	-0.9	0.9	-0.9	-1.5
Tibia length	0.6	1.7	2.2	1.5	-1.5	1.5	-0.4
Ambulatory time before self-admin	0.9	1.4	3.7	0.8	-0.8	0.8	1.9
Ambulatory time after self-admin	1.2	1.4	1.9	-1.4	1.4	-1.4	0.1
Bone: tissue strength	0.2	0.2	0.3	0.6	-0.6	0.6	-0.2
Total heroin consumption	3.3	3.8	4.9	2.2	-2.2	2.2	-0.9
Bone: trabecular number	0.8	1.3	3.1	-0.9	0.9	-0.9	-1.8
Bone: trabecular spacing	0.5	0.7	2.1	0.5	-0.5	0.5	1.5
Bone: trabecular thickness	0.2	0.3	0.4	0.6	-0.6	0.6	0.0
Bone: trabecular tissue density	0.4	0.6	2.2	-0.1	0.1	-0.1	-1.5
Water consumed over 24 hours	1.0	1.3	1.6	-1.3	1.3	-1.3	-0.6
Number of responses in last shaping day	0.6	0.7	0.9	-0.9	0.9	-0.9	-0.4