Olr59

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	intron excision ratio	chr1_157195372_157198411	0.02	0.02	3.9e-03	0.01	0.02	0	0.01	2.5e-02	5.6e-03	1.2e-01	3.3e-02
2	PL	alternative TSS	XM_008759671.1	0.03	0.02	1.2e-03	0.02	0.02	0.03	0.02	1.3e-03	2.0e-03	4.7e-04	1.9e-03
3	PL	intron excision ratio	chr1_157198543_157211031	0.02	0.02	1.9e-03	0	0.01	0	0	8.7e-02	1.2e-02	2.1e-01	1.2e-01
4	pVTA	gene expression	Olr59	0.17	0.09	1.2e-05	0.12	0.12	0.09	0.09	8.6e-06	8.2e-06	8.2e-05	8.2e-05
5	BLA	isoform ratio	XM_008759670.3	0.08	0.05	9.9e-03	0	0.02	-0	0	2.4e-01	3.9e-02	6.7e-01	1.6e-01
6	Liver	intron excision ratio	chr1_157195372_157198411	0.03	0.02	7.2e-03	0	0	-0	0	2.4e-01	1.0e-01	5.6e-01	2.6e-01
7	PL	gene expression	Olr59	0.17	0.08	3.4e-11	0.1	0.1	0.1	0.11	1.9e-11	3.5e-11	8.1e-11	2.3e-12
8	Brain	gene expression	Olr59	0.07	0.04	2.5e-04	0.05	0.04	0.05	0.05	1.5e-05	5.5e-05	2.6e-05	1.7e-05
9	Liver	gene expression	Olr59	0.05	0.04	2.6e-04	0.01	0.02	0.02	0.02	2.6e-02	1.6e-03	1.9e-03	5.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	1.0	1.7	3.3	-1.0	1.1	0.8	-1.7	1.8	0.1	-1.8	1.8	0.6
Area under the delay curve	0.8	0.9	2.5	-0.4	-0.6	0.2	-0.9	1.1	0.4	-1.2	1.6	0.9
BMI with tail	1.5	4.8	9.3	-1.2	-0.5	1.7	0.7	-1.7	-3.0	3.0	-2.8	-3.1
BMI without tail	1.7	3.5	7.7	1.3	-0.5	-0.9	2.3	-2.7	-0.5	2.8	-2.6	-1.4
Body weight	1.2	4.8	9.2	2.2	-2.0	-1.9	3.0	-3.0	0.5	2.8	-2.2	-0.3
Weight adjusted by age	1.6	1.8	3.8	1.7	-0.2	-1.6	1.9	-1.8	0.8	1.3	-1.0	0.2
Bone surface	0.8	1.5	2.9	0.5	1.0	-0.9	-0.5	1.0	1.5	-1.6	1.7	1.5
Bone volume	0.5	0.9	1.7	0.4	0.8	-0.7	-0.4	0.8	1.2	-1.2	1.3	1.1
Breakpoint value in progressive ratio session	0.9	1.0	2.4	-1.2	0.3	1.3	-0.5	0.1	-1.5	0.7	-0.7	-1.4
Number of licking bursts	0.6	0.7	2.6	-1.0	-1.6	1.1	-0.5	0.4	-1.0	-0.1	-0.4	-0.3
Context. condit. distance diff. score	0.6	0.7	3.1	0.6	1.8	-0.6	0.8	-0.9	0.1	0.7	-0.6	-0.6
Locomotion velocity, session 1	1.6	1.7	3.5	-1.8	0.7	1.9	-1.4	0.9	-1.8	0.2	-0.1	-1.5
Locomotion distance, session 1	0.7	0.8	2.4	-0.6	1.0	0.8	-0.1	-0.4	-1.2	0.9	-0.9	-1.5
Locomotion velocity, session 2	0.9	1.0	2.5	-0.9	0.5	1.1	-0.2	-0.3	-1.5	0.9	-1.1	-1.6
Locomotion distance, session 2	1.3	1.9	4.8	-0.6	0.8	0.9	0.4	-1.0	-1.7	1.6	-1.9	-2.2
Locomotion velocity, session 3	0.2	0.3	1.3	0.0	1.1	-0.1	-0.4	0.4	0.3	-0.6	0.6	0.1
Locomotion distance, session 3	0.5	0.6	3.0	-0.3	1.7	0.1	-0.7	0.7	0.2	-0.7	0.9	-0.0
Stereotopy head waving bouts, day 3	0.5	0.6	1.2	0.9	-1.1	-0.9	0.7	-0.4	0.9	-0.0	0.1	0.9
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.1	0.4	-0.0	0.1	-0.1	-0.1	0.2	-0.1	-0.3
Locomotion velocity, session 7	0.7	0.8	1.9	-0.9	0.7	1.1	-0.4	-0.0	-1.4	0.2	-0.8	-1.4
Locomotion distance, session 7	0.1	0.1	0.4	-0.0	-0.3	0.1	0.3	-0.4	-0.3	0.1	-0.7	-0.3
Stereotopy head waving bouts, day 7	0.8	0.9	3.7	0.3	1.9	-0.4	-0.6	0.7	0.8	-0.7	1.3	0.2
Stereotopy head waving duration, day 7	0.5	0.6	3.2	0.3	1.8	-0.4	-0.4	0.4	0.6	-0.3	1.0	-0.0
Locomotion velocity, session 8	0.2	0.3	1.2	0.5	1.1	-0.6	0.2	-0.2	0.6	-0.4	0.3	0.2
Locomotion distance, session 8	1.2	1.7	3.2	0.6	1.3	-0.5	1.4	-1.8	-0.6	1.6	-1.7	-1.4
Degree of sensitization distance	2.0	2.0	4.1	1.2	-2.0	-1.0	1.8	-1.8	0.2	1.2	-1.7	0.0
Degree of sensitization stereotypy	1.0	1.1	6.2	0.5	2.5	-0.7	-0.5	0.5	0.9	-0.4	1.2	0.0
Conditioned locomotion	0.4	0.5	2.8	0.5	-1.7	-0.5	0.6	-0.4	0.4	0.3	-0.3	0.6
Cocaine response after cond. corrected	0.3	0.4	2.1	-0.5	-1.4	0.6	-0.2	0.1	-0.6	0.3	-0.5	-0.3
Cocaine response after cond. not corrected	0.5	0.5	1.0	-0.8	-0.7	0.9	-0.4	0.2	-1.0	0.6	-0.6	-0.8
Cocaine response before conditioning	0.4	0.5	3.4	-0.6	1.8	0.4	-0.4	0.2	-0.5	0.2	0.1	-0.6
Saline control response	1.9	2.5	5.8	2.2	-0.3	-2.4	1.4	-0.8	2.4	-0.2	0.6	1.9
Bone: connectivity density	1.6	2.6	4.5	-1.9	1.9	1.7	-2.1	1.9	-1.0	-1.4	1.3	-0.5
Bone: cortical apparent density	0.5	0.7	3.9	0.4	-2.0	-0.3	0.8	-0.6	0.1	0.4	-0.7	0.4
Bone: cortical area	0.4	0.6	1.1	1.0	-0.4	-1.1	1.0	-0.7	0.9	0.1	-0.3	0.7
Bone: cortical porosity	1.0	1.1	2.7	0.0	0.7	-0.3	-0.9	1.2	1.0	-1.5	1.7	1.1
Bone: cortical porosity	1.1	1.2	2.8	0.2	0.6	-0.4	-0.8	1.1	1.1	-1.6	1.7	1.2
Bone: cortical thickness	0.2	0.3	0.7	-0.6	-0.1	0.7	-0.0	-0.2	-0.9	0.1	-0.6	-0.6
Bone: cortical thickness	0.0	0.1	0.1	0.2	-0.2	-0.1	0.2	-0.3	-0.1	0.3	-0.4	-0.3
Bone: cortical tissue density	0.5	0.7	3.9	0.3	-2.0	-0.2	0.8	-0.7	0.0	0.4	-0.7	0.4
Condit. Reinf. active minus inactive responses	1.1	1.2	2.8	1.7	-0.6	-1.7	1.1	-0.7	1.6	-0.1	0.1	1.1
Condit. Reinf. active-inactive response ratio	1.9	2.1	5.3	2.0	-0.6	-2.1	0.9	-0.3	2.3	-0.5	0.8	1.7
Condit. Reinf. active responses	0.7	0.9	1.9	1.1	-0.8	-1.2	0.6	-0.1	1.4	-0.5	0.5	1.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	-0.5	0.4	-0.1	0.1	-0.4	0.1	-0.0	-0.0
Incentive salience index mean	0.7	0.9	2.1	1.2	-0.6	-1.3	0.5	-0.1	1.5	-0.4	0.6	1.1
Condit. Reinf. lever presses	0.3	0.3	0.9	-0.2	0.2	0.1	-0.7	0.9	0.4	-0.7	0.9	0.4
Condit. Reinf. active minus inactive responses	2.1	2.6	5.9	2.4	1.3	-2.4	1.7	-1.4	1.9	0.8	-0.2	0.5
Condit. Reinf. active-inactive response ratio	0.2	0.3	1.3	0.5	1.2	-0.6	0.1	-0.1	0.6	0.0	0.3	0.2
Condit. Reinf. active responses	3.3	4.6	10.6	3.3	1.1	-3.2	2.6	-2.2	2.4	1.3	-0.7	0.7
Condit. Reinf. inactive responses	2.9	3.6	7.8	2.8	0.1	-2.6	2.5	-2.3	1.8	1.3	-1.0	0.4
Condit. Reinf. lever presses	3.8	5.1	9.0	3.0	2.3	-2.8	2.8	-2.8	1.6	2.0	-1.4	-0.5
Condit. Reinf. lever reinforcers received	3.1	4.3	9.9	3.1	1.4	-3.1	2.3	-2.0	2.5	1.0	-0.4	0.7
Conditioned reinforcement - actives	0.3	0.3	1.0	-0.4	0.7	0.3	-0.6	0.6	-0.1	-0.6	1.0	0.0
Conditioned reinforcement - inactives	0.4	0.5	1.3	0.6	-0.8	-0.7	0.4	-0.1	0.9	-0.3	0.8	1.1
Conditioned locomotion	0.7	0.9	3.3	-0.8	1.8	0.7	-1.0	0.8	-0.5	-0.3	1.0	-0.6
Patch foraging indifference point 0 sec	0.8	1.3	2.4	1.0	0.9	-0.9	1.4	-1.5	0.2	1.4	-1.4	-0.5
Patch foraging indifference point AUC	0.9	1.0	2.4	1.2	-0.8	-1.2	1.6	-1.4	0.6	0.8	-0.5	0.4
Delay disc. indifference point, 0s delay	0.2	0.2	0.5	0.5	0.3	-0.3	0.4	-0.6	0.0	0.7	-0.4	-0.5
Delay disc. indifference point, 16s delay	1.2	1.2	2.9	-0.0	-0.7	-0.1	-1.0	1.4	0.9	-1.6	1.7	1.1
Delay disc. indifference point, 2s delay	0.5	0.6	1.3	0.8	-0.4	-0.9	0.3	0.0	1.1	-0.5	0.9	1.1
Delay disc. indifference point, 24s delay	0.8	0.8	2.8	-0.3	-1.7	0.2	-0.6	0.8	0.4	-1.1	0.9	1.0
Delay disc. indifference point, 4s delay	0.5	0.5	1.1	1.1	-0.4	-1.0	0.8	-0.7	0.8	0.5	0.1	0.4
Delay disc. indifference point, 8s delay	0.3	0.4	1.0	-0.6	-0.5	0.5	-0.6	0.7	-0.1	-0.6	1.0	0.5
Indifference point function ln k	0.6	0.8	2.3	-0.6	1.5	0.6	-1.2	1.1	-0.1	-0.8	1.0	-0.1
Indifference point function log k	0.6	0.8	2.3	-0.6	1.5	0.6	-1.2	1.1	-0.1	-0.8	1.0	-0.1
Patch foraging total patch changes 0 sec	0.9	1.5	3.0	0.9	0.8	-0.7	1.5	-1.7	-0.1	1.6	-1.7	-0.8
Patch foraging total patch changes 12 sec	1.5	1.9	4.5	1.6	-0.8	-1.5	2.1	-2.0	0.7	1.3	-1.0	0.2
Patch foraging total patch changes 18 sec	0.6	0.8	1.7	0.8	-0.1	-0.8	1.3	-1.3	0.2	1.0	-1.1	-0.2
Patch foraging total patch changes 24 sec	1.7	2.1	4.3	1.7	-0.6	-1.7	2.1	-1.9	0.9	1.4	-1.3	0.3
Patch foraging total patch changes 6 sec	0.8	1.2	2.7	1.0	0.1	-1.0	1.6	-1.7	0.2	1.2	-1.2	-0.3
Patch foraging time to switch 0 sec	1.4	2.2	4.2	-1.8	-1.0	1.7	-2.1	2.0	-0.8	-1.5	0.9	0.2
Patch foraging water rate 0 sec	1.0	1.6	3.0	1.5	1.1	-1.4	1.7	-1.7	0.6	1.4	-0.9	-0.3
Patch foraging water rate 12 sec	2.4	3.6	7.7	-0.1	1.6	0.5	1.2	-2.0	-1.8	2.8	-2.5	-2.7
Patch foraging water rate 18 sec	1.5	2.0	4.5	1.0	1.2	-0.7	1.4	-1.8	-0.3	2.1	-1.6	-1.5
Patch foraging water rate 24 sec	0.7	0.9	2.2	-0.2	0.5	0.4	0.7	-1.1	-1.0	1.5	-1.2	-1.1
Patch foraging water rate 6 sec	0.5	0.7	1.9	-0.3	1.4	0.4	0.3	-0.7	-0.9	1.0	-0.6	-1.3
Seeking ratio, delayed vs. immediate footshock	1.4	1.7	3.5	-1.6	0.0	1.6	-1.9	1.7	-0.9	-1.3	0.9	-0.4
Distance traveled before self-admin	0.4	0.4	1.0	-0.9	-0.1	1.0	-0.6	0.3	-1.0	0.1	-0.2	-0.8
Distance traveled after self-admin	0.6	0.7	2.1	-0.8	1.5	0.9	-0.7	0.3	-0.9	0.2	-0.2	-1.2
Extensor digitorum longus weight	0.3	1.1	2.7	0.2	-1.6	-0.2	1.3	-1.4	-0.5	1.1	-1.5	-0.2
Bone: elastic displacement	1.1	1.3	3.1	-1.7	0.0	1.8	-1.2	0.8	-1.6	-0.1	0.0	-1.0
Bone: elastic work	2.3	3.0	6.9	-2.6	0.5	2.6	-1.8	1.3	-2.4	-0.2	-0.1	-1.6
Bone: endosteal estimation	0.8	1.8	4.1	1.9	-0.3	-2.0	1.3	-0.8	2.0	0.1	0.3	1.5
Bone: endosteal perimeter	0.9	1.8	4.4	2.0	0.2	-2.1	1.3	-0.8	2.0	0.0	0.3	1.3
Epididymis fat weight	0.8	1.8	3.8	0.5	-1.8	-0.2	1.4	-1.6	-0.6	1.8	-2.0	-0.7
Delta time in closed arm before/after self-admin	1.2	1.2	6.0	0.8	-2.4	-0.7	1.1	-0.9	0.4	0.6	-0.6	0.5
Delta time in open arm before/after self-admin	1.0	0.9	2.4	1.3	0.8	-1.4	0.4	-0.1	1.5	-0.4	0.8	0.9
Diff in mean of infusions in LGA sessions	0.8	0.9	3.1	0.4	-1.8	-0.5	-0.2	0.6	1.0	-0.8	0.7	1.3
Delay discount exponential model param	0.8	0.9	2.3	0.6	0.7	-0.4	1.0	-1.2	-0.2	1.2	-1.5	-0.8
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.4	-0.1	0.5	-0.3	0.2	-0.4	0.1	-0.1	-0.3
Active lever presses in extinction session 6	0.8	0.7	5.0	-0.5	2.2	0.4	-0.6	0.5	-0.3	-0.2	0.4	-0.6
Bone: final force	0.9	1.5	4.2	0.9	-1.6	-1.2	0.4	0.2	1.6	-0.9	0.9	2.1
Bone: final moment	0.8	1.3	3.7	1.0	-1.4	-1.2	0.5	0.1	1.6	-0.8	0.8	1.9
Food consumed during 24 hour testing period	0.4	0.5	3.6	0.4	1.9	-0.5	0.2	-0.2	0.4	-0.0	0.4	0.1
Glucose	0.4	0.6	1.2	-1.0	1.1	1.0	-0.7	0.4	-0.9	-0.2	-0.0	-0.7
Heart weight	0.3	0.5	1.3	0.9	1.2	-0.9	0.4	-0.3	0.9	-0.1	-0.0	0.1
Delay discount hyperbolic model param	0.6	0.6	1.9	0.3	0.6	-0.2	0.7	-0.9	-0.4	1.0	-1.4	-0.8
Intermittent access intake day 1-15 change	0.9	0.9	1.7	-0.3	0.7	0.3	0.7	-1.1	-1.1	1.3	-1.1	-1.2
Intermittent access intake escalation	0.6	0.6	1.1	-0.4	0.8	0.4	0.5	-0.8	-1.0	1.0	-0.8	-1.0
Intermittent access intake escalation 2	0.9	0.9	1.7	-0.0	-0.8	0.2	1.1	-1.3	-0.9	1.3	-1.3	-0.7
Intermitt. access day 1 inactive lever presses	0.3	0.4	1.1	0.4	-0.2	-0.4	0.1	0.2	0.7	-0.5	1.0	1.0
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.0	0.8	0.8	-0.9	0.4	-0.1	1.0	-0.2	0.7	0.7
Intermitt. access escalation Index	0.4	0.4	0.6	0.8	-0.8	-0.7	0.7	-0.5	0.7	-0.1	-0.3	0.6
Intermittent access day 1 total infusions	0.4	0.5	1.2	0.5	0.7	-0.6	-0.3	0.5	1.0	-0.7	1.1	0.7
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.2	0.2	-0.3	0.2	-0.1	0.3	0.0	0.4	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.3	0.2	-0.4	0.4	-0.3	0.3	0.1	0.3	0.2
Intermittent access total infusions	0.2	0.2	0.6	0.2	0.2	-0.4	-0.1	0.2	0.6	-0.4	0.8	0.6
Intermittent access day 1 locomotion	1.1	1.2	2.6	-0.2	0.3	0.0	-1.2	1.5	0.8	-1.6	1.6	1.1
Intermittent access day 15 total locomotion	0.4	0.5	1.7	-0.5	1.3	0.3	-0.7	0.7	-0.0	-0.7	0.8	-0.0
Intermittent access total locomotion	0.2	0.2	0.7	-0.1	0.8	-0.0	-0.5	0.6	0.3	-0.4	0.5	0.2
Intermittent access standard deviation	0.3	0.3	0.8	-0.3	-0.6	0.3	0.6	-0.7	-0.7	0.9	-0.5	-0.4
Left kidney weight	1.0	2.9	6.0	1.8	-0.4	-1.6	2.4	-2.5	0.5	2.3	-1.6	-0.4
Right kidney weight	0.9	2.5	5.2	1.9	-0.9	-1.8	2.3	-2.1	1.0	1.8	-0.8	0.3
Cocaine induced anxiety	0.6	0.7	2.1	-0.2	-1.4	0.0	-0.4	0.8	0.5	-1.0	0.7	1.3
Post-drug Anxiety	1.2	1.4	3.2	1.2	-1.8	-1.3	0.5	0.1	1.6	-0.6	0.4	1.6
Baseline Anxiety	0.9	1.0	2.5	1.5	0.3	-1.6	0.7	-0.4	1.6	-0.3	0.4	0.8
Tail length	4.5	13.6	29.2	5.4	-1.4	-5.3	4.6	-3.7	4.3	1.6	-1.2	2.4
Length with tail	3.1	11.4	22.9	4.8	-2.3	-4.7	4.2	-3.4	3.7	1.7	-1.3	2.2
Length without tail	0.1	0.1	0.8	0.1	-0.9	-0.1	0.1	0.0	0.2	0.1	0.2	0.3
Times rat made contact with spout	0.1	0.1	0.4	0.1	-0.7	-0.2	-0.0	0.2	0.4	-0.4	0.3	0.6
Lifetime Intake	0.1	0.1	0.3	0.3	0.3	-0.4	0.1	-0.0	0.4	-0.2	0.5	0.3
Liver weight, left	1.2	1.9	8.1	0.8	-2.8	-0.9	0.5	0.1	1.3	-0.9	0.7	2.0
Liver weight, right	2.2	3.6	11.6	1.9	-3.4	-2.0	1.6	-0.8	2.1	-0.4	0.1	2.4
Locomotor activity	0.5	0.7	1.8	0.4	0.5	-0.1	0.7	-1.0	-0.5	1.3	-1.2	-1.2
Locomotor testing distance	0.8	1.3	3.2	0.8	1.0	-0.5	1.0	-1.3	-0.3	1.8	-1.3	-1.4
Locomotor testing rearing	0.5	0.8	1.4	1.1	-0.2	-0.9	1.2	-1.2	0.4	1.2	-0.7	-0.3
Locomotion in novel chamber	0.9	1.1	2.0	-1.3	1.2	1.4	-1.0	0.6	-1.3	-0.2	-0.1	-1.1
Locomotion in novel chamber post-restriction	0.7	0.9	3.3	-0.8	1.8	0.7	-1.2	1.0	-0.3	-0.8	0.7	-0.4
Fecal boli incidents, locomotor time 1	1.3	1.4	3.3	-1.1	0.1	0.9	-1.7	1.8	-0.1	-1.7	1.2	0.6
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	0.1	-0.2	0.0	0.4	-0.6	-0.4	0.8	-0.5	-0.6
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.4	0.5	-0.1	-0.7	0.0	0.2	0.9	-0.7	1.2	0.8
Bouts of movement, locomotor time 1	1.4	1.5	4.0	0.8	0.7	-1.0	-0.4	0.8	1.6	-1.4	2.0	1.4
Total resting periods, locomotor time 1	1.1	1.2	2.8	0.1	0.9	-0.3	-0.9	1.2	1.0	-1.5	1.7	1.1
Rest time, locomotor task time 1	0.4	0.4	0.9	0.1	0.9	-0.2	-0.5	0.7	0.6	-0.8	0.8	0.7
Distance moved, locomotor task time 1	0.4	0.4	1.6	0.2	-1.2	-0.2	0.8	-0.8	-0.2	0.8	-0.4	-0.2
Vertical activity count, locomotor time 1	0.2	0.2	0.7	0.4	-0.8	-0.4	0.5	-0.4	0.2	0.3	0.1	0.2
Time >=10cm from walls, locomotor time 2	1.6	1.7	3.8	1.9	-0.7	-1.9	1.4	-1.0	1.7	0.2	-0.2	1.1
Bouts of movement, locomotor time 2	1.5	1.6	3.4	1.3	-1.6	-1.4	0.3	0.2	1.8	-1.0	0.8	1.8
Total resting periods, locomotor time 2	1.1	1.2	2.6	0.7	-1.5	-0.9	-0.0	0.5	1.4	-1.1	0.9	1.6
Rest time, locomotor task time 2	1.0	1.1	2.8	-1.6	-0.4	1.7	-1.0	0.7	-1.5	-0.0	-0.3	-0.8
Distance moved, locomotor task time 2	1.1	1.3	2.5	1.5	-0.1	-1.6	1.6	-1.4	1.0	0.8	-0.9	0.5
Vertical activity count, locomotor time 2	0.7	0.7	1.4	1.1	-0.7	-1.2	1.0	-0.7	1.0	0.2	-0.2	0.9
Light reinforcement 1	0.9	1.7	4.5	-1.8	-0.4	2.0	-0.8	0.3	-2.1	0.1	-1.0	-1.3
Light reinforcement 2	2.4	3.2	7.5	-2.1	1.6	2.3	-0.9	0.0	-2.7	0.8	-1.1	-2.5
Bone: marrow area	0.8	1.7	3.7	1.8	-0.4	-1.9	1.2	-0.7	1.9	-0.0	0.3	1.5
Bone: maximum diameter	1.0	1.8	4.3	2.0	0.3	-2.1	1.5	-1.1	1.8	0.1	0.0	1.1
Bone: maximum force	0.6	1.1	3.2	0.7	-0.9	-0.9	0.1	0.4	1.4	-1.1	1.0	1.8
Bone: maximum moment	0.4	0.7	2.2	0.6	-0.6	-0.9	0.2	0.2	1.2	-0.9	0.8	1.5
Mean time between licks in bursts	4.6	6.5	14.7	3.8	-0.8	-3.8	3.1	-2.5	3.0	1.1	-0.7	1.5
Mean num. licks in bursts	0.6	0.7	2.1	1.0	1.4	-1.1	0.4	-0.2	1.2	-0.1	0.6	0.5
Cd content in liver	0.1	0.2	0.4	-0.3	-0.6	0.3	-0.3	0.4	-0.1	-0.5	0.5	0.4
Co content in liver	2.5	2.9	7.0	2.2	-0.2	-2.4	1.1	-0.4	2.7	-1.1	0.9	2.2
Cu content in liver	1.3	1.6	3.6	1.7	-0.6	-1.8	1.0	-0.5	1.9	-0.5	0.7	1.6
Fe content in liver	0.9	1.1	2.9	0.6	-0.5	-0.8	-0.2	0.7	1.4	-1.2	1.4	1.7
K content in liver	0.2	0.2	1.0	0.1	-1.0	-0.1	0.4	-0.4	-0.1	-0.1	-0.8	0.0
Mg content in liver	0.1	0.1	0.3	-0.0	0.3	0.1	0.0	-0.2	-0.3	0.1	-0.5	-0.5
Mn content in liver	2.0	2.3	4.5	-2.1	0.5	2.1	-2.1	1.7	-1.6	-0.9	0.3	-1.0
Na content in liver	1.0	1.0	3.3	-0.3	1.2	0.1	-1.0	1.1	0.5	-1.8	1.2	0.6
Rb content in liver	1.4	1.8	4.8	0.6	0.5	-1.0	-0.3	0.9	1.7	-2.2	1.6	1.7
Se content in liver	2.6	3.1	6.1	-2.0	-0.2	1.7	-2.3	2.5	-0.5	-2.4	1.8	0.8
Sr content in liver	1.8	1.7	4.0	-1.0	1.3	1.3	-0.2	-0.4	-1.8	1.2	-1.4	-2.0
Zn content in liver	1.1	1.2	2.2	0.5	1.3	-0.3	1.0	-1.3	-0.4	1.5	-1.3	-1.2
Bone: minimum diameter	1.3	2.4	4.5	2.0	-1.3	-2.1	1.8	-1.3	1.9	0.3	-0.3	1.6
Time in familiar zone, hab. session 1	0.6	0.5	1.3	0.5	-0.2	-0.4	1.1	-1.1	-0.2	0.9	-1.0	-0.3
Time in novel zone, hab. session 1	0.3	0.3	0.5	0.1	-0.3	-0.1	-0.6	0.7	0.5	-0.7	0.7	0.4
Total zone transitions, hab. session 1	0.4	0.6	2.1	-0.7	1.4	0.6	-0.9	0.8	-0.3	-0.8	0.6	-0.4
Total locomotion distance, hab. session 1	1.4	2.0	3.8	1.5	-1.9	-1.3	1.9	-1.7	0.7	1.0	-1.4	0.4
Locomotion velocity, hab. session 1	1.2	1.7	3.3	1.2	-1.8	-1.0	1.7	-1.7	0.3	1.2	-1.5	0.2
Time in familiar zone, hab. session 2	1.9	2.0	4.1	2.0	-0.2	-2.0	1.8	-1.6	1.4	1.2	-0.7	0.5
Time in novel zone, hab. session 2	1.8	1.8	3.9	-1.9	0.6	2.0	-1.3	0.8	-1.9	-0.2	-0.4	-1.4
Total zone transitions, hab. session 2	0.5	0.6	2.5	0.6	1.6	-0.6	0.7	-0.8	0.1	0.6	-0.6	-0.8
Total locomotion distance, hab. session 2	3.7	4.9	9.7	2.3	-1.9	-2.0	3.1	-3.1	0.7	2.3	-2.5	-0.0
Locomotion velocity, hab. session 2	3.7	4.9	9.8	2.3	-2.0	-2.0	3.1	-3.0	0.7	2.3	-2.5	0.0
Novel to familiar place preference ratio	1.9	2.0	4.6	1.7	-0.9	-1.8	0.7	-0.1	2.2	-0.9	0.9	2.0
Novelty place preference	1.6	1.7	4.0	1.6	-0.8	-1.7	0.8	-0.2	2.0	-0.8	0.7	1.7
Time in novel zone, NPP test	1.8	1.9	4.4	1.8	-0.7	-1.9	0.9	-0.4	2.1	-0.7	0.6	1.8
Total zone transitions, NPP test	0.9	1.3	2.7	-1.2	1.4	1.3	-0.8	0.3	-1.5	0.4	-0.5	-1.6
Total locomotion distance, NPP test	2.4	3.3	8.2	0.5	-1.5	-0.1	1.9	-2.3	-1.2	2.5	-2.9	-1.5
Locomotion velocity, NPP test	2.1	3.0	7.5	0.1	-1.6	0.3	1.6	-2.1	-1.5	2.4	-2.7	-1.5
Intraocular pressure	1.4	2.0	4.4	-1.1	1.7	0.8	-1.7	1.8	-0.1	-1.4	2.1	0.3
Delta distance traveled before/after self-admin	0.7	0.7	1.7	1.2	1.0	-1.2	0.5	-0.2	1.3	-0.2	0.6	0.7
Delta ambulatory time before/after self-admin	0.6	0.6	1.9	0.7	1.4	-0.8	-0.0	0.2	1.0	-0.5	0.9	0.6
Parametrial fat weight	0.6	1.2	2.8	-1.4	0.3	1.6	-0.8	0.3	-1.7	0.3	-0.9	-1.4
Pavlov. Cond. lever latency	0.4	0.5	1.1	-0.6	-0.6	0.6	0.4	-0.6	-1.0	0.8	-1.1	-0.6
Pavlov. Cond. magazine entry latency	0.6	0.8	1.5	1.2	0.9	-1.1	1.0	-1.0	0.6	0.9	-0.7	-0.5
Pavlov. Cond. change in total contacts	1.4	1.5	3.3	1.0	0.5	-1.2	-0.3	0.8	1.8	-1.3	1.7	1.5
Pavlov. Cond. index score	0.3	0.4	1.1	0.9	1.1	-0.9	0.1	-0.0	0.9	-0.2	0.5	0.1
Pavlov. Cond. latency score	0.4	0.5	1.2	0.9	0.9	-1.0	0.0	0.1	1.1	-0.4	0.7	0.4
Pavlov. Cond. lever contacts	0.3	0.3	0.6	0.4	0.6	-0.5	-0.4	0.5	0.8	-0.5	0.8	0.3
Pavlov. Cond. magazine entry number	0.4	0.5	2.0	-0.8	-1.4	0.8	-0.2	0.2	-0.7	-0.0	-0.3	0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.2	-0.5	-0.6	0.3	-0.7	0.9	0.2	-1.1	1.0	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.2	0.7	1.1	-0.7	-0.1	0.2	0.9	-0.4	0.7	0.2
Pavlov. Cond. response bias	0.1	0.1	0.4	0.6	0.6	-0.5	0.2	-0.1	0.5	0.2	0.1	-0.1
Pavlov. Cond. lever latency	4.8	6.5	11.6	-2.8	-2.5	2.5	-3.1	3.4	-0.8	-3.0	2.3	1.5
Pavlov. Cond. magazine entry latency	3.3	3.9	8.1	0.1	2.1	0.3	1.2	-2.0	-1.7	2.7	-2.5	-2.8
Pavlov. Cond. change in total contacts	3.6	4.9	7.9	2.4	2.7	-2.2	2.5	-2.8	0.8	2.5	-1.8	-1.3
Pavlov. Cond. index score	4.1	5.3	9.5	2.1	2.4	-1.7	2.6	-3.1	0.1	2.9	-2.5	-2.0
Pavlov. Cond. latency score	3.9	4.9	8.4	1.7	2.4	-1.3	2.3	-2.9	-0.3	2.9	-2.5	-2.2
Pavlov. Cond. lever contacts	4.5	6.1	9.9	2.9	2.7	-2.7	2.9	-3.2	1.1	2.6	-1.9	-1.2
Pavlov. Cond. magazine entry number	2.7	3.4	6.0	-0.8	-2.5	0.4	-1.5	2.2	0.9	-2.4	2.1	2.4
Pavlov. Cond. intertrial magazine entries	1.2	1.5	3.6	1.4	-0.8	-1.5	0.5	0.0	1.9	-0.8	1.0	1.8
Pavlov. Cond. lever-magazine prob. diff.	4.2	5.3	9.7	2.1	2.3	-1.8	2.7	-3.1	0.1	2.9	-2.5	-1.9
Pavlov. Cond. response bias	4.6	6.3	10.3	2.6	3.0	-2.3	2.8	-3.2	0.7	2.9	-2.2	-1.8
Time in closed arm before self-admin	0.6	0.7	3.3	-0.1	1.8	0.2	0.0	-0.4	-0.5	0.8	-0.3	-1.3
Time in closed arm after self-admin	0.2	0.2	0.5	-0.4	-0.5	0.3	-0.6	0.6	-0.1	-0.4	0.7	0.1
Time in open arm before self-admin	0.8	0.8	1.9	-1.3	-1.2	1.4	-0.8	0.7	-1.1	-0.3	-0.4	-0.1
Time in open arm after self-admin	0.3	0.4	0.6	0.8	-0.7	-0.7	0.7	-0.5	0.6	0.2	-0.4	0.5
Bone: periosteal estimation	0.6	1.2	2.7	1.5	-0.2	-1.6	1.1	-0.7	1.6	-0.1	0.2	1.2
Bone: periosteal perimeter	0.7	1.2	2.5	1.5	-0.1	-1.6	1.4	-1.2	1.2	0.4	-0.4	0.7
Bone: post-yield work	0.0	0.0	0.1	0.2	0.2	-0.2	0.2	-0.2	0.1	0.1	-0.2	0.0
Progressive ratio test 1 active lever presses	0.3	0.3	1.1	-0.2	0.2	0.1	-0.6	0.7	0.3	-0.6	1.1	0.4
Progressive ratio test 1 breakpoint	0.2	0.2	1.0	-0.1	0.1	-0.0	-0.4	0.6	0.4	-0.6	1.0	0.5
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	-0.1	0.4	0.0	-0.3	0.4	0.2	-0.3	0.5	0.3
Progressive ratio test 2 active lever presses	0.6	0.7	1.6	0.1	-0.2	-0.3	-0.6	0.9	0.8	-1.2	1.3	1.1
Progressive ratio test 2 breakpoint	0.6	0.7	1.6	0.3	-0.3	-0.5	-0.4	0.7	1.0	-1.1	1.3	1.1
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.6	-0.0	0.3	-0.1	-0.4	0.5	0.4	-0.6	0.8	0.5
Incentive Sensitization - Responses	0.3	0.3	0.6	0.6	0.1	-0.7	0.3	-0.1	0.8	-0.4	0.6	0.8
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	0.3	0.2	-0.4	0.2	-0.0	0.5	-0.3	0.5	0.5
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.1	-0.2	0.4	0.3	0.5	-0.7	-0.8	1.1	-0.9	-0.9
Progressive ratio	0.3	0.4	0.9	-0.6	0.9	0.6	-0.7	0.5	-0.6	-0.1	0.3	-0.8
Food seeking constrained by brief footshock	1.9	2.3	4.1	2.0	-1.1	-1.8	2.0	-1.9	1.0	1.5	-1.3	0.0
Seeking ratio, punishment vs. effort	1.4	1.7	3.2	1.5	-1.3	-1.4	1.8	-1.6	0.8	1.3	-1.3	0.3
Retroperitoneal fat weight	1.3	4.2	14.4	1.0	-3.8	-0.6	2.2	-2.3	-0.4	2.2	-2.6	-0.2
Reaction time number correct	0.2	0.3	0.7	-0.6	0.6	0.7	-0.4	0.2	-0.8	0.3	-0.1	-0.8
Reaction time mean minus median	0.6	0.8	1.6	1.0	-0.6	-0.8	1.2	-1.3	0.2	1.0	-0.9	-0.4
Reaction time mean minus median AUC	0.3	0.3	0.8	0.5	-0.2	-0.4	0.8	-0.9	-0.1	0.8	-0.7	-0.5
Reaction time num false alarms	0.7	0.9	6.2	-0.2	-2.5	0.1	-0.2	0.5	0.3	-0.8	0.3	1.0
Reaction time num false alarms AUC	0.5	0.8	4.7	-0.4	-2.2	0.4	-0.4	0.6	0.0	-0.8	0.2	0.8
Reaction time trials correct on left	0.2	0.3	0.7	-0.6	0.6	0.7	-0.4	0.2	-0.8	0.3	-0.1	-0.8
Reaction time trials on left	0.2	0.4	0.8	-0.6	0.6	0.7	-0.4	0.1	-0.8	0.4	-0.1	-0.9
Reaction time mean	0.5	0.7	5.3	0.2	-2.3	-0.2	0.5	-0.3	0.1	0.1	-0.5	0.6
Reaction time mean AUC	0.5	0.6	4.5	-0.0	-2.1	0.0	0.1	0.2	0.2	-0.4	-0.1	0.8
Median of all reaction times	0.5	0.7	5.3	-0.2	-2.3	0.2	0.1	0.1	-0.1	-0.2	-0.3	0.7
Reaction time omissions	0.4	0.6	1.2	-0.5	-1.1	0.7	0.3	-0.5	-1.0	0.7	-0.8	-0.7
Reaction time false alarm rate	0.5	0.8	5.5	-0.2	-2.3	0.2	-0.1	0.3	0.1	-0.6	0.0	0.9
Reaction time premature initiation rate	2.5	3.3	7.2	2.1	-1.3	-2.0	2.7	-2.5	0.9	2.2	-0.8	0.2
Reaction time premature initiations	1.4	2.0	4.6	1.4	-0.8	-1.2	2.1	-2.1	0.2	2.1	-0.8	-0.4
Std. dev. reaction times	0.6	0.9	3.1	1.1	-1.8	-1.0	1.0	-0.8	0.8	0.3	-0.2	0.7
Reaction time trials completed	0.2	0.4	0.8	-0.6	0.6	0.7	-0.4	0.1	-0.8	0.4	-0.1	-0.9
Reaction time trials AUC	0.2	0.2	0.7	-0.4	0.3	0.5	-0.1	-0.2	-0.7	0.6	-0.3	-0.8
Run reversals in cocaine runway, females	2.1	2.0	3.8	1.2	-1.1	-0.9	1.8	-2.0	-0.1	1.9	-1.9	-0.6
Run reversals in cocaine runway, males	0.5	0.5	1.1	-0.6	-0.3	0.4	-0.7	0.9	0.1	-1.0	0.9	0.6
Latency to leave start box in cocaine runway	0.3	0.3	0.7	-0.8	0.1	0.9	-0.8	0.7	-0.6	-0.3	0.3	-0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.6	0.1	-0.8	0.1	0.1	-0.1	-0.1	0.2	-0.2	0.1
Latency to leave start box in cocaine runway, M	1.6	1.5	2.5	-1.6	1.0	1.4	-1.6	1.5	-0.7	-1.2	1.1	0.1
Std. dev. time between licks in bursts	2.8	3.3	5.9	2.4	-1.4	-2.4	2.4	-2.0	1.7	1.1	-0.9	1.2
Total sessions with >9 infusions	0.5	0.5	2.8	-0.5	1.7	0.5	-0.4	0.1	-0.6	0.1	0.2	-0.9
Short access day 1 total inactive lever presses	0.7	0.8	2.6	0.2	0.0	-0.4	-0.4	0.8	0.9	-1.0	1.6	1.1
Short access day 10 total inactive lever presses	0.0	0.0	0.2	-0.3	-0.4	0.2	0.0	0.0	-0.2	-0.0	-0.0	0.3
Short access day 1 total infusions	0.2	0.2	0.4	0.6	0.1	-0.6	0.6	-0.5	0.4	0.3	-0.1	0.1
Short access day 10 total infusions	0.1	0.1	0.3	0.5	0.3	-0.5	0.2	-0.1	0.5	0.0	0.6	0.2
Short access total infusions	0.2	0.2	0.4	0.6	0.3	-0.6	0.5	-0.5	0.5	0.3	-0.0	0.1
Short access day 1 locomotion	1.0	1.0	4.4	-0.9	2.1	0.8	-1.0	0.8	-0.6	-0.5	0.8	-0.6
Short access day 10 total locomotion	0.3	0.3	0.7	-0.6	0.6	0.7	-0.2	-0.1	-0.8	0.2	-0.5	-0.6
Short access total locomotion	0.5	0.5	1.0	-0.8	1.0	0.7	-0.9	0.9	-0.3	-0.7	0.5	-0.1
One hour access (0.3 mA shock)	0.6	0.7	1.4	-0.1	0.0	0.2	0.7	-1.0	-0.8	1.2	-1.1	-1.0
Compulsive drug intake	0.2	0.2	0.4	-0.6	-0.2	0.6	-0.6	0.5	-0.5	-0.4	-0.1	-0.3
One hour access (shock baseline)	0.3	0.3	0.8	0.5	0.1	-0.4	0.8	-0.9	0.0	0.9	-0.4	-0.2
Social response proportion	1.2	1.3	2.7	0.7	-1.6	-0.5	1.4	-1.4	-0.1	1.3	-1.5	-0.1
Social responses	1.2	1.6	4.1	1.0	-2.0	-0.9	1.6	-1.4	0.4	1.1	-1.5	0.4
Social time	0.8	1.1	2.4	-1.6	-0.6	1.5	-1.3	1.2	-1.0	-0.9	0.4	-0.0
Soleus weight	0.7	2.1	5.5	1.2	-2.3	-1.1	1.8	-1.7	0.4	1.3	-1.6	0.3
Bone: stiffness	1.9	3.0	7.6	1.6	-2.3	-1.9	0.9	-0.0	2.3	-1.1	0.9	2.8
Tibialis anterior weight	0.5	1.7	3.5	1.4	-1.6	-1.5	1.9	-1.5	1.0	0.7	-0.6	1.1
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.5	0.6	-0.7	0.4	-0.2	0.7	-0.1	0.6	0.5
Time to tail flick, vehicle, after self-admin	0.8	0.9	4.5	0.1	2.1	-0.1	-0.9	0.9	0.6	-0.7	0.9	-0.1
Time to tail flick, test, before self-admin	1.0	0.9	2.4	1.3	1.1	-1.3	0.2	0.1	1.5	-0.5	0.9	0.7
Time to tail flick, test, after self-admin	2.7	2.8	6.6	2.6	-0.5	-2.6	1.7	-1.1	2.4	0.3	0.0	1.4
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	2.9	-0.6	1.7	0.6	-1.2	1.0	-0.3	-0.7	0.5	-0.5
Delta time to tail flick, test, before/after SA	0.8	0.7	1.5	0.5	-1.2	-0.5	1.1	-1.1	-0.0	0.8	-1.0	0.1
Tibia length	0.4	1.3	2.7	0.1	1.6	-0.3	-1.0	1.2	1.0	-1.4	1.6	0.8
Ambulatory time before self-admin	0.4	0.5	1.1	-1.0	-0.1	1.0	-0.8	0.6	-0.9	-0.2	-0.1	-0.5
Ambulatory time after self-admin	0.5	0.5	2.5	-0.5	1.6	0.5	-0.8	0.7	-0.2	-0.5	0.5	-0.3
Bone: tissue strength	2.0	1.9	3.7	-1.9	1.6	1.9	-1.4	0.9	-1.8	-0.2	-0.0	-1.3
Total heroin consumption	0.8	0.9	2.2	0.3	0.4	-0.1	0.9	-1.2	-0.6	1.5	-1.3	-1.1
Bone: trabecular number	1.6	2.5	4.8	-2.0	0.9	1.8	-2.2	2.1	-1.0	-1.5	1.4	-0.1
Bone: trabecular spacing	0.9	1.2	2.9	-0.2	0.8	0.5	0.4	-0.9	-1.1	1.6	-1.4	-1.7
Bone: trabecular thickness	1.2	1.5	3.4	1.0	-0.5	-1.2	0.1	0.5	1.8	-1.4	1.3	1.8
Bone: trabecular tissue density	2.3	3.3	8.9	1.9	-3.0	-2.0	1.3	-0.5	2.2	-0.7	0.5	2.4
Water consumed over 24 hours	0.2	0.2	0.5	-0.5	-0.3	0.4	-0.5	0.6	-0.1	-0.7	0.5	0.5
Number of responses in last shaping day	0.8	0.8	1.8	0.4	-1.3	-0.6	-0.2	0.6	1.0	-1.1	1.1	1.3