Hub : Genes

Nutf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Nutf2	0.03	0.03	3.3e-04	0.02	0.02	0.02	0.02	1.7e-03	2.2e-03	1.0e-03	2.9e-03
2	Brain	mRNA stability	Nutf2	0.11	0.06	1.0e-10	0.13	0.09	0.12	0.12	6.6e-12	2.7e-08	5.5e-11	2.3e-11
3	PL	mRNA stability	Nutf2	0.02	0.02	1.4e-03	0.01	0.01	0.01	0.01	1.3e-02	1.1e-02	1.3e-02	2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.1	0.2	0.5	-0.3	-0.4
Area under the delay curve	0.2	0.2	0.5	-0.7	0.1	-0.0
BMI with tail	0.1	0.2	0.6	0.2	-0.7	-0.2
BMI without tail	0.0	0.1	0.1	-0.3	-0.2	0.2
Body weight	0.3	1.3	1.6	1.3	-1.2	-0.9
Weight adjusted by age	0.0	0.0	0.0	-0.1	-0.1	-0.1
Bone surface	1.2	2.1	2.7	1.6	-1.2	-1.5
Bone volume	1.0	1.8	2.2	1.5	-1.0	-1.5
Breakpoint value in progressive ratio session	1.6	1.9	2.1	-1.3	1.4	1.4
Number of licking bursts	0.4	0.7	0.8	0.9	-0.9	-0.6
Context. condit. distance diff. score	0.2	0.2	0.4	-0.3	0.6	0.3
Locomotion velocity, session 1	0.0	0.0	0.1	0.1	-0.3	-0.1
Locomotion distance, session 1	0.2	0.2	0.3	-0.4	0.5	0.5
Locomotion velocity, session 2	1.3	1.5	1.8	-1.1	1.3	1.3
Locomotion distance, session 2	0.3	0.4	0.7	-0.4	0.6	0.8
Locomotion velocity, session 3	0.3	0.3	0.4	-0.6	0.3	0.6
Locomotion distance, session 3	0.1	0.1	0.1	-0.2	0.4	0.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.2	-0.5	-0.3
Stereotopy head waving duration, day 3	0.5	0.6	0.7	0.8	-0.8	-0.7
Locomotion velocity, session 7	0.1	0.1	0.2	-0.2	0.4	-0.2
Locomotion distance, session 7	0.1	0.1	0.2	-0.3	0.4	0.0
Stereotopy head waving bouts, day 7	0.2	0.3	0.4	0.5	-0.6	-0.5
Stereotopy head waving duration, day 7	0.8	0.9	1.3	0.9	-1.1	-0.8
Locomotion velocity, session 8	0.0	0.0	0.1	-0.1	0.1	0.3
Locomotion distance, session 8	0.7	1.0	1.1	-0.9	1.1	1.0
Degree of sensitization distance	0.0	0.0	0.1	0.0	-0.1	-0.3
Degree of sensitization stereotypy	0.5	0.5	0.6	0.7	-0.8	-0.7
Conditioned locomotion	1.6	1.8	2.4	1.6	-1.1	-1.3
Cocaine response after cond. corrected	0.9	1.1	1.5	0.8	-1.2	-1.1
Cocaine response after cond. not corrected	0.3	0.3	0.7	0.2	-0.8	-0.5
Cocaine response before conditioning	1.3	1.6	2.1	-1.2	1.1	1.4
Saline control response	3.6	4.7	5.2	2.3	-2.3	-2.0
Bone: connectivity density	0.0	0.0	0.1	-0.1	0.2	0.2
Bone: cortical apparent density	0.5	0.7	1.3	-1.1	0.6	0.8
Bone: cortical area	0.3	0.5	0.9	0.6	-0.4	-0.9
Bone: cortical porosity	0.6	0.6	1.2	-0.6	1.1	0.6
Bone: cortical porosity	0.4	0.5	0.9	-0.5	1.0	0.5
Bone: cortical thickness	0.1	0.2	0.4	0.4	-0.3	-0.6
Bone: cortical thickness	0.1	0.1	0.4	0.0	0.6	-0.2
Bone: cortical tissue density	0.6	0.8	1.4	-1.2	0.6	0.8
Condit. Reinf. active minus inactive responses	4.0	4.4	5.2	-2.3	2.2	1.7
Condit. Reinf. active-inactive response ratio	3.4	3.6	4.4	-2.1	2.0	1.6
Condit. Reinf. active responses	3.1	3.8	4.6	-2.1	2.1	1.6
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.4	0.6	0.4
Incentive salience index mean	2.3	2.9	3.6	-1.8	1.9	1.4
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.6	0.7	0.4
Condit. Reinf. active minus inactive responses	0.7	1.0	1.2	0.8	-1.0	-1.1
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.0	0.8	-1.0	-1.0
Condit. Reinf. active responses	0.3	0.4	0.5	0.5	-0.6	-0.7
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.6	0.7	0.6
Condit. Reinf. lever presses	3.2	4.4	4.9	-1.9	2.2	2.2
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	0.0	-0.0	-0.1
Conditioned reinforcement - actives	0.7	1.2	1.7	-1.3	1.0	1.0
Conditioned reinforcement - inactives	0.3	0.4	0.5	0.5	-0.7	-0.6
Conditioned locomotion	0.9	1.2	1.2	1.0	-1.1	-1.1
Patch foraging indifference point 0 sec	2.6	4.8	4.9	2.2	-2.2	-2.2
Patch foraging indifference point AUC	1.3	1.9	2.8	1.7	-1.3	-1.2
Delay disc. indifference point, 0s delay	0.8	0.9	1.5	-1.2	0.6	0.9
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.1	0.1	-0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.1	-0.4	-0.6
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.1	0.4	0.0
Delay disc. indifference point, 4s delay	0.4	0.4	1.1	-1.1	0.1	0.3
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	-0.8	-0.1	-0.2
Indifference point function ln k	0.1	0.2	0.4	-0.7	0.3	0.2
Indifference point function log k	0.1	0.2	0.4	-0.7	0.3	0.2
Patch foraging total patch changes 0 sec	2.5	4.8	5.0	2.2	-2.2	-2.1
Patch foraging total patch changes 12 sec	2.4	3.1	4.3	2.1	-1.6	-1.5
Patch foraging total patch changes 18 sec	2.2	3.4	4.7	2.2	-1.5	-1.9
Patch foraging total patch changes 24 sec	0.1	0.2	0.6	0.8	-0.3	-0.2
Patch foraging total patch changes 6 sec	1.7	2.6	3.0	1.7	-1.7	-1.4
Patch foraging time to switch 0 sec	0.9	1.8	1.9	-1.4	1.3	1.4
Patch foraging water rate 0 sec	1.6	3.3	4.7	2.2	-1.7	-1.6
Patch foraging water rate 12 sec	0.2	0.5	0.8	0.9	-0.7	-0.5
Patch foraging water rate 18 sec	0.1	0.2	0.3	0.5	-0.3	-0.4
Patch foraging water rate 24 sec	0.0	0.1	0.1	0.3	-0.1	-0.3
Patch foraging water rate 6 sec	1.1	1.6	2.1	1.5	-1.0	-1.3
Seeking ratio, delayed vs. immediate footshock	2.4	3.0	3.6	1.7	-1.6	-1.9
Distance traveled before self-admin	0.6	0.7	1.8	0.5	-0.5	-1.3
Distance traveled after self-admin	0.1	0.1	0.2	0.0	-0.2	-0.4
Extensor digitorum longus weight	0.8	3.3	5.1	-1.3	2.3	1.7
Bone: elastic displacement	2.3	2.7	3.1	1.5	-1.8	-1.7
Bone: elastic work	0.9	1.2	1.5	1.0	-1.1	-1.2
Bone: endosteal estimation	0.1	0.1	0.2	0.3	-0.1	-0.5
Bone: endosteal perimeter	0.1	0.2	0.4	0.6	-0.0	-0.7
Epididymis fat weight	2.1	7.3	8.7	3.0	-2.3	-2.8
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.1	-0.2	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.1	-0.5	-0.2
Diff in mean of infusions in LGA sessions	0.6	0.8	0.9	-0.8	1.0	0.9
Delay discount exponential model param	0.2	0.2	0.6	0.8	-0.2	-0.1
Extinction: sum of active levers before priming	0.4	0.5	0.9	-0.6	0.5	1.0
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.3	0.1	-0.1
Bone: final force	1.2	1.9	2.7	-1.3	1.7	1.1
Bone: final moment	0.5	0.8	1.2	-0.8	1.1	0.6
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.5	-0.0	-0.2
Glucose	1.3	2.0	2.9	-1.7	1.0	1.4
Heart weight	0.0	0.0	0.1	-0.1	-0.3	0.0
Delay discount hyperbolic model param	0.3	0.3	0.9	0.9	-0.2	-0.2
Intermittent access intake day 1-15 change	1.3	2.7	3.7	-1.9	1.3	1.6
Intermittent access intake escalation	1.4	2.9	3.8	-2.0	1.4	1.7
Intermittent access intake escalation 2	1.1	1.2	1.8	-1.3	0.8	1.1
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.3	-0.1	0.4
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	-0.2	0.4	0.1
Intermitt. access escalation Index	0.3	0.4	0.7	0.8	-0.6	-0.5
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.3	-0.1	0.2
Intermittent access day 15 total infusions	1.7	2.5	3.9	-2.0	1.1	1.6
Intermittent access terminal intake (last 3 days)	2.9	3.8	5.2	-2.3	1.6	1.9
Intermittent access total infusions	2.3	2.7	3.6	-1.9	1.4	1.6
Intermittent access day 1 locomotion	1.4	1.8	2.5	1.2	-1.6	-1.2
Intermittent access day 15 total locomotion	0.4	0.7	1.4	0.4	-1.2	-0.7
Intermittent access total locomotion	0.2	0.3	0.5	0.1	-0.7	-0.5
Intermittent access standard deviation	0.2	0.4	0.6	0.5	-0.8	-0.6
Left kidney weight	1.7	8.1	9.5	-2.5	3.1	3.0
Right kidney weight	1.8	8.4	9.9	-2.5	3.2	3.0
Cocaine induced anxiety	2.9	4.1	5.0	2.0	-2.2	-1.9
Post-drug Anxiety	0.7	0.8	1.3	0.8	-1.1	-0.7
Baseline Anxiety	1.7	2.0	2.1	-1.4	1.3	1.4
Tail length	0.0	0.1	0.2	0.1	0.4	0.2
Length with tail	0.1	0.5	1.2	1.1	-0.3	-0.5
Length without tail	0.5	1.6	2.1	1.5	-1.2	-1.0
Times rat made contact with spout	1.0	1.1	1.3	1.1	-1.0	-1.1
Lifetime Intake	1.8	2.2	2.9	-1.7	1.3	1.4
Liver weight, left	0.2	0.4	0.6	0.8	-0.5	-0.4
Liver weight, right	0.3	0.6	1.1	1.0	-0.6	-0.5
Locomotor activity	2.6	4.1	4.7	2.1	-1.8	-2.2
Locomotor testing distance	2.0	3.5	4.2	1.8	-1.7	-2.1
Locomotor testing rearing	0.3	0.7	0.8	0.9	-0.6	-0.9
Locomotion in novel chamber	2.4	3.0	3.5	1.6	-1.7	-1.9
Locomotion in novel chamber post-restriction	1.4	2.3	2.7	1.3	-1.6	-1.7
Fecal boli incidents, locomotor time 1	0.7	1.0	1.3	1.1	-1.1	-0.7
Change in fecal boli incidents, locomotor task	0.5	0.5	0.8	-0.8	0.4	0.9
Time >=10cm from walls, locomotor time 1	0.2	0.3	0.6	0.2	-0.8	-0.3
Bouts of movement, locomotor time 1	0.1	0.2	0.3	0.4	-0.6	-0.0
Total resting periods, locomotor time 1	0.0	0.1	0.1	0.1	-0.3	0.2
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.2	-0.2	0.6
Distance moved, locomotor task time 1	0.1	0.2	0.4	0.2	-0.3	-0.6
Vertical activity count, locomotor time 1	0.4	0.9	1.7	0.9	-0.6	-1.3
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.7	-0.8	0.3	0.7
Bouts of movement, locomotor time 2	0.6	1.0	1.2	-0.9	1.1	1.0
Total resting periods, locomotor time 2	0.7	1.3	1.5	-1.0	1.2	1.1
Rest time, locomotor task time 2	0.5	0.7	1.2	-0.7	0.5	1.1
Distance moved, locomotor task time 2	1.0	1.2	1.8	0.9	-1.0	-1.3
Vertical activity count, locomotor time 2	1.1	1.6	2.2	1.2	-1.0	-1.5
Light reinforcement 1	2.0	5.0	6.1	2.5	-1.7	-2.4
Light reinforcement 2	2.0	3.1	4.2	1.6	-1.6	-2.0
Bone: marrow area	0.0	0.1	0.2	0.3	-0.1	-0.4
Bone: maximum diameter	0.3	0.7	1.0	0.7	-0.6	-1.0
Bone: maximum force	0.3	0.5	0.8	-0.6	0.9	0.5
Bone: maximum moment	0.0	0.0	0.1	-0.2	0.3	0.0
Mean time between licks in bursts	0.0	0.0	0.1	0.1	-0.1	-0.4
Mean num. licks in bursts	0.0	0.0	0.1	-0.0	0.3	-0.2
Cd content in liver	0.0	0.0	0.0	-0.2	0.2	0.1
Co content in liver	0.0	0.0	0.0	-0.2	0.1	-0.1
Cu content in liver	1.0	1.1	1.3	-0.9	1.1	1.1
Fe content in liver	2.2	2.6	3.0	1.6	-1.7	-1.6
K content in liver	0.2	0.2	0.3	-0.5	-0.1	0.4
Mg content in liver	0.4	0.5	0.8	0.6	-0.9	-0.5
Mn content in liver	0.9	1.0	1.4	0.9	-1.2	-0.9
Na content in liver	0.3	0.3	1.0	-0.2	-1.0	-0.0
Rb content in liver	0.4	0.4	0.8	-0.3	0.9	0.6
Se content in liver	0.1	0.1	0.2	-0.1	0.5	-0.2
Sr content in liver	1.0	0.8	1.3	1.1	-0.7	-0.9
Zn content in liver	1.7	1.9	2.5	-1.6	1.3	1.2
Bone: minimum diameter	0.2	0.3	0.6	0.5	-0.3	-0.8
Time in familiar zone, hab. session 1	0.6	0.6	0.7	0.8	-0.8	-0.7
Time in novel zone, hab. session 1	0.4	0.4	0.6	-0.8	0.6	0.5
Total zone transitions, hab. session 1	0.7	0.9	1.4	1.2	-0.9	-0.8
Total locomotion distance, hab. session 1	0.8	1.1	1.5	1.2	-0.9	-1.0
Locomotion velocity, hab. session 1	0.9	1.3	1.8	1.3	-1.0	-1.0
Time in familiar zone, hab. session 2	1.3	1.4	1.9	0.8	-1.2	-1.4
Time in novel zone, hab. session 2	4.6	4.6	5.1	-2.1	2.1	2.3
Total zone transitions, hab. session 2	1.4	1.8	2.7	1.6	-1.2	-1.2
Total locomotion distance, hab. session 2	0.8	1.0	1.5	1.2	-0.8	-1.0
Locomotion velocity, hab. session 2	0.6	0.9	1.4	1.2	-0.7	-0.8
Novel to familiar place preference ratio	1.7	1.8	2.2	-1.5	1.1	1.4
Novelty place preference	2.7	3.0	3.6	-1.9	1.5	1.8
Time in novel zone, NPP test	2.5	2.7	3.4	-1.9	1.4	1.6
Total zone transitions, NPP test	1.4	2.1	2.9	1.7	-1.3	-1.3
Total locomotion distance, NPP test	0.6	0.8	1.3	1.2	-0.6	-0.8
Locomotion velocity, NPP test	0.5	0.7	1.2	1.1	-0.5	-0.7
Intraocular pressure	0.5	0.8	1.6	-0.5	1.3	0.7
Delta distance traveled before/after self-admin	0.3	0.3	0.8	-0.2	0.4	0.9
Delta ambulatory time before/after self-admin	0.7	0.9	1.5	-0.9	0.6	1.2
Parametrial fat weight	7.4	17.5	19.4	4.4	-4.2	-4.0
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.3	-0.6	-0.4
Pavlov. Cond. magazine entry latency	1.1	1.4	2.4	-1.0	1.5	0.9
Pavlov. Cond. change in total contacts	1.1	1.2	1.5	-1.0	1.2	1.1
Pavlov. Cond. index score	0.9	1.2	1.9	-0.8	1.4	1.0
Pavlov. Cond. latency score	0.7	0.9	1.5	-0.7	1.2	0.8
Pavlov. Cond. lever contacts	0.8	1.0	1.3	-0.8	1.1	1.0
Pavlov. Cond. magazine entry number	1.1	1.4	2.1	1.0	-1.4	-1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	0.4	-0.5	-0.9
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.9	-0.9	1.4	1.0
Pavlov. Cond. response bias	0.6	0.8	1.3	-0.7	1.1	0.8
Pavlov. Cond. lever latency	1.7	2.3	2.6	1.5	-1.6	-1.5
Pavlov. Cond. magazine entry latency	4.1	5.0	5.7	-2.3	2.4	1.9
Pavlov. Cond. change in total contacts	2.1	3.4	4.8	-1.7	2.2	1.6
Pavlov. Cond. index score	4.1	5.6	6.4	-2.4	2.5	2.2
Pavlov. Cond. latency score	4.2	5.6	6.3	-2.4	2.5	2.2
Pavlov. Cond. lever contacts	2.2	3.0	3.6	-1.6	1.9	1.7
Pavlov. Cond. magazine entry number	6.1	7.6	8.6	2.9	-2.9	-2.4
Pavlov. Cond. intertrial magazine entries	4.3	6.5	6.8	2.6	-2.4	-2.6
Pavlov. Cond. lever-magazine prob. diff.	4.6	6.1	6.9	-2.5	2.6	2.2
Pavlov. Cond. response bias	3.8	5.1	6.0	-2.3	2.4	2.0
Time in closed arm before self-admin	3.3	4.3	5.9	2.4	-2.1	-1.5
Time in closed arm after self-admin	2.6	2.8	3.2	1.6	-1.8	-1.5
Time in open arm before self-admin	2.6	2.9	3.8	-1.8	1.9	1.3
Time in open arm after self-admin	0.4	0.4	0.6	-0.8	0.7	0.4
Bone: periosteal estimation	0.2	0.5	0.9	0.7	-0.3	-1.0
Bone: periosteal perimeter	0.6	1.0	1.5	1.1	-0.6	-1.2
Bone: post-yield work	0.6	0.9	1.0	0.9	-1.0	-1.0
Progressive ratio test 1 active lever presses	3.5	4.3	4.9	-2.1	2.2	1.9
Progressive ratio test 1 breakpoint	3.1	3.8	4.4	-2.0	2.1	1.8
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	-0.5	0.0	0.4
Progressive ratio test 2 active lever presses	2.5	2.9	4.0	-2.0	1.4	1.7
Progressive ratio test 2 breakpoint	2.7	3.0	4.0	-2.0	1.4	1.8
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	-0.5	0.0	0.2
Incentive Sensitization - Responses	0.8	1.1	1.7	-1.3	0.6	1.2
Incentive Sensitization - Breakpoint	1.0	1.4	1.9	-1.4	0.7	1.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.5	0.6	0.3
Progressive ratio	0.2	0.3	0.8	-0.1	0.9	-0.1
Food seeking constrained by brief footshock	1.7	2.1	2.5	-1.4	1.4	1.6
Seeking ratio, punishment vs. effort	0.4	0.6	1.2	-0.7	0.2	1.1
Retroperitoneal fat weight	7.0	29.9	31.2	5.5	-5.3	-5.6
Reaction time number correct	1.1	2.2	2.5	-1.6	1.4	1.4
Reaction time mean minus median	0.7	1.8	2.8	-1.2	1.7	1.0
Reaction time mean minus median AUC	0.6	1.5	2.9	-1.0	1.7	0.9
Reaction time num false alarms	0.1	0.1	0.2	-0.2	0.1	0.5
Reaction time num false alarms AUC	0.0	0.0	0.0	0.1	-0.2	0.1
Reaction time trials correct on left	1.1	2.2	2.5	-1.6	1.4	1.4
Reaction time trials on left	1.2	2.3	2.6	-1.6	1.5	1.5
Reaction time mean	0.0	0.0	0.1	0.0	0.4	-0.1
Reaction time mean AUC	0.1	0.1	0.3	-0.2	0.6	0.2
Median of all reaction times	0.1	0.1	0.2	0.5	-0.1	-0.4
Reaction time omissions	0.1	0.1	0.3	-0.1	0.5	-0.1
Reaction time false alarm rate	0.5	0.7	0.8	0.9	-0.9	-0.6
Reaction time premature initiation rate	1.2	1.6	2.0	-1.1	1.4	1.3
Reaction time premature initiations	2.3	4.2	4.6	-1.9	2.1	2.0
Std. dev. reaction times	0.2	0.3	0.6	-0.6	0.8	0.3
Reaction time trials completed	1.2	2.3	2.6	-1.6	1.5	1.5
Reaction time trials AUC	1.2	2.3	2.6	-1.6	1.5	1.5
Run reversals in cocaine runway, females	2.4	2.4	3.1	1.5	-1.8	-1.3
Run reversals in cocaine runway, males	0.4	0.5	0.6	0.8	-0.7	-0.5
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.4	-0.1	0.4
Latency to leave start box in cocaine runway, F	0.6	0.7	1.2	-0.9	0.3	1.1
Latency to leave start box in cocaine runway, M	2.1	2.0	4.3	2.1	-0.7	-1.0
Std. dev. time between licks in bursts	1.7	2.3	2.7	1.6	-1.3	-1.7
Total sessions with >9 infusions	1.5	1.9	2.5	-1.6	1.4	1.1
Short access day 1 total inactive lever presses	0.0	0.1	0.1	0.0	-0.2	-0.4
Short access day 10 total inactive lever presses	0.1	0.2	0.3	0.5	-0.6	-0.4
Short access day 1 total infusions	0.3	0.4	0.6	-0.8	0.5	0.6
Short access day 10 total infusions	0.3	0.4	0.4	-0.6	0.6	0.6
Short access total infusions	1.8	2.3	2.6	-1.6	1.5	1.4
Short access day 1 locomotion	0.3	0.3	0.6	-0.8	0.4	0.5
Short access day 10 total locomotion	1.9	3.5	4.2	1.8	-1.8	-2.0
Short access total locomotion	0.5	0.6	0.8	0.7	-0.7	-0.9
One hour access (0.3 mA shock)	1.4	1.6	2.0	-1.4	1.1	1.3
Compulsive drug intake	0.1	0.1	0.2	0.4	-0.3	-0.4
One hour access (shock baseline)	1.0	1.6	2.1	-1.5	0.9	1.3
Social response proportion	0.6	0.7	1.0	-1.0	0.7	0.8
Social responses	0.0	0.1	0.1	-0.4	0.2	-0.0
Social time	0.0	0.0	0.1	-0.2	0.1	-0.1
Soleus weight	0.2	0.6	0.7	0.8	-0.6	-0.9
Bone: stiffness	3.8	6.1	7.7	-2.4	2.8	2.3
Tibialis anterior weight	0.4	1.5	2.7	-0.7	1.6	1.1
Time to tail flick, vehicle, before self-admin	0.6	0.7	1.0	-1.0	0.6	0.8
Time to tail flick, vehicle, after self-admin	0.7	0.9	1.2	0.7	-1.0	-1.1
Time to tail flick, test, before self-admin	2.5	2.6	3.5	1.9	-1.5	-1.5
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	0.1	-0.3
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.4	1.0	-0.7	-1.2
Delta time to tail flick, test, before/after SA	1.3	1.3	1.7	-1.2	1.3	0.9
Tibia length	0.0	0.1	0.2	-0.0	0.4	0.3
Ambulatory time before self-admin	0.9	1.4	2.6	0.9	-0.9	-1.6
Ambulatory time after self-admin	0.2	0.2	0.4	-0.0	-0.6	-0.7
Bone: tissue strength	0.1	0.1	0.1	-0.4	-0.3	0.2
Total heroin consumption	0.8	1.0	1.2	-1.0	0.8	1.1
Bone: trabecular number	0.3	0.6	0.7	0.8	-0.7	-0.7
Bone: trabecular spacing	0.1	0.1	0.1	0.4	-0.2	-0.2
Bone: trabecular thickness	0.5	0.6	0.8	-0.8	0.9	0.7
Bone: trabecular tissue density	0.7	1.0	1.2	-1.0	0.9	1.1
Water consumed over 24 hours	0.1	0.2	0.3	0.6	-0.3	-0.3
Number of responses in last shaping day	0.5	0.6	0.8	-0.7	0.9	0.7