Hub : Genes

Npr3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Npr3 0.09 0.07 2.8e-03 0.01 0 0.02 0.01 4.2e-02 9.9e-02 2.8e-03 3.1e-02
2 IC intron excision ratio chr2_62645325_62657996 0.06 0.04 9.3e-03 0.04 0.05 0.02 0.05 6.4e-03 5.2e-03 3.8e-02 3.4e-03
3 Brain isoform ratio XM_006232045.5 0.06 0.04 1.5e-03 0.01 0.01 0 0.01 2.5e-02 3.1e-02 1.3e-01 3.6e-02
4 Brain alternative TSS XM_006232045.5 0.06 0.04 1.5e-03 0.01 0.01 0.01 0.01 2.6e-02 5.2e-02 2.6e-02 4.6e-02
5 Brain alternative TSS XM_039101782.2 0.06 0.04 1.1e-03 0.01 0.01 0.01 0.01 2.3e-02 4.3e-02 2.2e-02 3.8e-02
6 PL alternative TSS XM_006232045.5 0.03 0.02 4.3e-03 0.01 0.01 0.01 0.01 5.9e-02 1.7e-02 4.9e-02 5.9e-02
7 Adipose alternative TSS XM_006232045.5 0.08 0.05 1.8e-08 0.06 0.06 0.06 0.06 2.4e-07 5.8e-07 5.1e-07 2.9e-07
8 Adipose isoform ratio XM_006232045.5 0.07 0.04 2.5e-06 0.04 0.04 0.04 0.04 1.4e-05 2.6e-05 6.1e-05 3.8e-05
9 Brain isoform ratio XM_039101782.2 0.08 0.05 1.2e-04 0.02 0.02 0.01 0.02 4.0e-03 6.9e-03 6.2e-02 8.9e-03
10 IL isoform ratio XM_006232045.5 0.24 0.13 8.2e-03 0.01 0.09 0.05 0.05 1.4e-01 3.7e-03 2.2e-02 2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.91.64.0-2.00.40.41.0-1.0-0.01.81.8-0.71.6
Area under the delay curve0.70.91.50.31.21.21.0-1.00.90.50.5-1.1-0.9
BMI with tail0.72.522.24.7-0.7-0.7-0.40.40.80.40.40.30.5
BMI without tail1.02.920.44.50.50.60.8-0.81.81.01.0-1.0-0.5
Body weight0.73.128.45.3-0.5-0.5-0.20.11.10.40.40.50.6
Weight adjusted by age0.10.20.60.80.20.30.1-0.10.20.60.6-0.1-0.5
Bone surface1.11.94.7-0.8-1.9-1.9-1.31.3-2.2-0.4-0.41.70.5
Bone volume1.01.74.5-1.1-1.8-1.8-1.11.1-2.1-0.2-0.21.50.6
Breakpoint value in progressive ratio session0.30.41.6-0.50.80.8-0.30.30.4-0.0-0.0-0.61.3
Number of licking bursts0.20.41.31.10.30.40.3-0.30.70.60.6-0.20.8
Context. condit. distance diff. score1.92.34.0-1.12.01.91.6-1.61.51.31.3-2.00.5
Locomotion velocity, session 10.10.10.3-0.40.10.0-0.30.2-0.1-0.2-0.20.20.5
Locomotion distance, session 10.10.10.4-0.60.30.30.4-0.40.10.40.4-0.10.1
Locomotion velocity, session 20.80.91.3-0.81.11.21.1-1.10.71.01.0-1.0-0.1
Locomotion distance, session 20.30.41.2-1.10.60.60.6-0.60.10.60.6-0.3-0.4
Locomotion velocity, session 30.80.94.6-0.5-0.0-0.1-0.40.4-0.7-1.1-1.10.9-2.1
Locomotion distance, session 30.70.82.40.4-0.4-0.4-0.70.8-0.7-1.1-1.11.0-1.6
Stereotopy head waving bouts, day 30.60.71.2-0.31.11.00.8-0.81.00.70.7-1.10.6
Stereotopy head waving duration, day 31.21.42.1-0.31.41.31.3-1.31.31.11.1-1.40.3
Locomotion velocity, session 70.20.20.5-0.50.20.1-0.40.4-0.3-0.7-0.7-0.3-0.7
Locomotion distance, session 70.10.10.3-0.50.10.0-0.20.2-0.3-0.2-0.2-0.1-0.3
Stereotopy head waving bouts, day 70.20.20.5-0.70.50.40.5-0.50.30.60.6-0.50.2
Stereotopy head waving duration, day 70.50.61.4-1.20.60.60.9-0.90.30.80.8-0.7-0.2
Locomotion velocity, session 80.60.81.0-0.81.00.91.0-1.00.70.90.9-0.90.4
Locomotion distance, session 81.11.52.6-1.61.41.31.3-1.30.81.31.3-1.20.5
Degree of sensitization distance0.50.51.0-0.80.40.40.6-0.60.40.90.9-0.91.0
Degree of sensitization stereotypy0.70.81.6-0.40.80.71.1-1.00.61.31.3-0.8-0.1
Conditioned locomotion0.30.31.00.1-0.7-0.7-0.30.4-0.7-0.4-0.40.6-1.0
Cocaine response after cond. corrected0.40.51.11.1-0.8-0.60.4-0.4-0.31.01.00.5-0.6
Cocaine response after cond. not corrected0.80.93.71.9-0.6-0.50.6-0.6-0.11.21.20.4-1.2
Cocaine response before conditioning0.40.41.41.20.70.50.5-0.50.50.30.3-0.6-1.1
Saline control response2.53.44.70.1-2.2-2.0-2.02.0-2.2-2.0-2.02.0-0.6
Bone: connectivity density1.32.16.3-2.50.80.81.4-1.40.21.91.9-0.91.1
Bone: cortical apparent density0.20.30.7-0.10.70.80.1-0.10.6-0.6-0.6-0.6-0.4
Bone: cortical area2.23.44.70.8-2.0-2.0-2.22.2-1.8-2.1-2.12.1-0.4
Bone: cortical porosity0.40.43.6-0.3-0.0-0.00.4-0.4-0.40.30.30.0-1.9
Bone: cortical porosity0.20.21.5-0.20.10.10.5-0.5-0.20.50.5-0.1-1.2
Bone: cortical thickness0.30.52.41.5-0.1-0.1-0.40.40.3-0.8-0.80.4-0.8
Bone: cortical thickness0.40.42.80.30.50.50.0-0.00.80.00.0-0.41.7
Bone: cortical tissue density0.20.30.8-0.10.80.90.1-0.10.6-0.5-0.5-0.6-0.3
Condit. Reinf. active minus inactive responses0.40.41.9-1.4-0.1-0.2-0.50.5-0.7-0.8-0.80.0-0.6
Condit. Reinf. active-inactive response ratio0.80.81.9-0.3-0.5-0.5-1.21.2-0.8-1.4-1.40.50.3
Condit. Reinf. active responses0.81.05.9-2.4-0.2-0.3-0.30.3-1.1-0.7-0.70.1-1.1
Condit. Reinf. inactive responses1.11.33.4-1.5-0.9-0.9-0.60.6-1.4-1.0-1.00.9-1.9
Incentive salience index mean0.50.64.4-2.1-0.3-0.3-0.40.4-0.9-0.6-0.60.1-0.2
Condit. Reinf. lever presses0.70.96.1-2.5-0.4-0.5-0.50.5-1.1-0.7-0.70.5-0.0
Condit. Reinf. active minus inactive responses0.91.23.60.8-1.1-1.0-0.80.9-1.0-1.1-1.10.9-1.9
Condit. Reinf. active-inactive response ratio0.30.31.11.0-0.0-0.0-0.60.60.1-0.9-0.90.1-0.3
Condit. Reinf. active responses1.01.57.20.4-1.2-1.1-0.60.6-1.4-0.8-0.80.9-2.7
Condit. Reinf. inactive responses0.91.27.8-0.3-1.0-0.9-0.00.1-1.3-0.3-0.30.7-2.8
Condit. Reinf. lever presses2.63.75.31.2-2.3-2.2-1.71.8-2.1-1.8-1.82.1-1.8
Condit. Reinf. lever reinforcers received0.91.34.60.7-1.2-1.1-0.70.7-1.3-0.9-0.90.9-2.2
Conditioned reinforcement - actives0.50.81.21.1-1.1-1.1-1.11.1-0.6-0.4-0.40.70.7
Conditioned reinforcement - inactives0.60.82.31.5-0.7-0.4-1.11.1-0.3-1.1-1.10.8-0.4
Conditioned locomotion1.31.73.50.9-1.2-1.3-1.91.8-1.0-1.4-1.41.20.5
Patch foraging indifference point 0 sec1.12.03.30.0-1.7-1.7-1.51.5-1.8-1.2-1.21.80.2
Patch foraging indifference point AUC0.00.00.10.20.10.2-0.00.0-0.10.00.00.2-0.4
Delay disc. indifference point, 0s delay0.90.93.30.1-0.0-0.0-0.70.7-0.8-1.5-1.50.4-1.8
Delay disc. indifference point, 16s delay4.44.97.4-0.22.62.72.3-2.32.42.32.3-2.70.8
Delay disc. indifference point, 2s delay1.41.62.41.51.41.51.2-1.21.40.50.5-1.2-1.6
Delay disc. indifference point, 24s delay2.42.64.70.42.12.21.6-1.62.11.41.4-1.80.6
Delay disc. indifference point, 4s delay0.30.42.20.20.60.50.5-0.50.2-0.1-0.1-0.4-1.5
Delay disc. indifference point, 8s delay0.30.40.7-0.0-0.5-0.6-0.40.4-0.8-0.8-0.80.5-0.8
Indifference point function ln k0.10.10.5-0.70.20.10.1-0.10.2-0.1-0.1-0.50.7
Indifference point function log k0.10.10.5-0.70.20.10.1-0.10.2-0.1-0.1-0.50.7
Patch foraging total patch changes 0 sec1.12.03.50.5-1.8-1.8-1.51.5-1.7-1.1-1.11.90.2
Patch foraging total patch changes 12 sec2.33.06.31.5-2.1-1.9-1.81.8-1.7-1.3-1.32.5-0.6
Patch foraging total patch changes 18 sec1.62.43.61.6-1.8-1.7-1.71.7-1.4-1.3-1.31.9-0.1
Patch foraging total patch changes 24 sec1.22.07.02.7-1.5-1.4-1.51.5-0.9-0.7-0.71.50.5
Patch foraging total patch changes 6 sec0.10.10.30.1-0.2-0.10.2-0.3-0.30.50.50.30.1
Patch foraging time to switch 0 sec0.10.10.20.0-0.4-0.30.3-0.3-0.10.50.5-0.1-0.3
Patch foraging water rate 0 sec0.10.21.21.10.0-0.20.2-0.10.30.20.20.3-0.8
Patch foraging water rate 12 sec0.51.06.42.5-0.4-0.5-0.80.80.4-0.7-0.70.60.4
Patch foraging water rate 18 sec0.50.84.22.1-0.1-0.1-0.90.90.5-0.7-0.70.60.9
Patch foraging water rate 24 sec1.01.42.40.6-0.9-1.1-1.61.6-0.6-1.6-1.61.10.4
Patch foraging water rate 6 sec0.50.82.21.5-0.4-0.6-0.90.90.1-1.1-1.10.80.2
Seeking ratio, delayed vs. immediate footshock0.50.63.7-1.90.60.70.1-0.10.10.20.2-0.60.9
Distance traveled before self-admin0.50.73.91.2-0.1-0.4-0.60.60.40.20.20.32.0
Distance traveled after self-admin1.11.42.20.9-1.0-1.4-1.51.5-0.9-1.2-1.21.50.2
Extensor digitorum longus weight0.72.64.71.11.71.71.8-1.82.21.71.7-1.60.2
Bone: elastic displacement1.01.28.81.30.30.30.2-0.10.2-0.7-0.7-0.2-3.0
Bone: elastic work0.91.25.92.1-0.3-0.4-0.20.3-0.1-0.6-0.60.4-2.4
Bone: endosteal estimation1.32.84.70.9-2.1-2.2-2.01.9-1.9-0.9-0.92.01.2
Bone: endosteal perimeter2.04.27.40.3-2.6-2.7-2.12.2-2.7-1.5-1.52.5-0.5
Epididymis fat weight0.51.63.21.71.31.20.8-0.91.81.01.0-0.61.8
Delta time in closed arm before/after self-admin0.10.10.50.30.30.40.4-0.40.2-0.2-0.2-0.4-0.7
Delta time in open arm before/after self-admin1.11.11.91.0-1.3-1.4-1.21.2-0.9-0.8-0.80.70.7
Diff in mean of infusions in LGA sessions0.20.30.90.10.60.8-0.20.20.7-0.3-0.3-0.30.9
Delay discount exponential model param1.11.22.0-0.4-1.4-1.4-1.31.2-1.1-0.7-0.71.30.9
Extinction: sum of active levers before priming0.20.20.6-0.70.60.60.1-0.20.40.10.1-0.60.8
Active lever presses in extinction session 60.30.30.80.00.90.6-0.20.10.40.40.4-0.70.7
Bone: final force1.42.34.30.7-2.0-2.1-1.71.7-1.7-1.1-1.11.70.4
Bone: final moment1.62.54.31.3-2.0-2.1-1.81.8-1.6-1.2-1.21.80.2
Food consumed during 24 hour testing period0.20.30.60.30.60.70.7-0.70.80.50.5-0.2-0.1
Glucose0.20.32.61.6-0.1-0.00.0-0.00.30.10.1-0.10.0
Heart weight2.53.96.1-0.0-2.3-2.3-1.92.0-2.5-1.9-1.91.9-2.1
Delay discount hyperbolic model param1.11.31.9-0.5-1.4-1.4-1.31.3-1.1-0.7-0.71.31.1
Intermittent access intake day 1-15 change0.20.43.10.2-0.1-0.2-0.60.60.2-0.1-0.10.21.8
Intermittent access intake escalation0.20.53.6-0.0-0.2-0.3-0.60.60.1-0.1-0.10.21.9
Intermittent access intake escalation 20.40.53.4-0.80.30.10.0-0.10.40.50.5-0.31.8
Intermitt. access day 1 inactive lever presses0.10.40.91.0-0.3-0.2-0.80.80.1-0.9-0.90.20.5
Intermitt. access day 15 inactive lever presses0.20.51.1-0.80.91.10.5-0.60.80.00.0-1.00.0
Intermitt. access escalation Index0.20.30.70.30.70.60.5-0.50.80.20.2-0.80.4
Intermittent access day 1 total infusions0.20.30.50.30.40.70.4-0.50.40.70.7-0.50.5
Intermittent access day 15 total infusions0.30.53.40.50.10.2-0.0-0.00.40.60.6-0.21.9
Intermittent access terminal intake (last 3 days)1.01.32.91.00.80.80.8-0.81.21.51.5-0.81.7
Intermittent access total infusions0.20.20.70.8-0.5-0.4-0.40.4-0.30.10.10.40.7
Intermittent access day 1 locomotion0.40.62.11.5-0.8-0.8-0.80.8-0.5-0.5-0.50.50.3
Intermittent access day 15 total locomotion0.20.32.00.7-0.1-0.1-0.30.20.20.40.40.11.4
Intermittent access total locomotion0.60.72.71.7-0.9-0.9-0.70.7-0.40.20.20.70.9
Intermittent access standard deviation0.30.64.9-0.0-0.1-0.1-0.20.20.20.50.5-0.32.2
Left kidney weight1.25.510.23.21.51.62.4-2.42.63.03.0-1.70.0
Right kidney weight1.56.79.92.92.12.22.7-2.73.13.23.2-2.01.3
Cocaine induced anxiety0.20.32.20.30.10.10.4-0.30.10.10.1-0.0-1.5
Post-drug Anxiety0.40.43.40.2-0.2-0.30.1-0.0-0.3-0.3-0.30.4-1.8
Baseline Anxiety0.20.20.50.1-0.3-0.4-0.20.3-0.5-0.6-0.60.4-0.7
Tail length0.52.13.01.21.61.61.7-1.71.71.31.3-1.3-0.4
Length with tail0.31.33.01.71.00.90.9-1.01.31.21.2-0.41.3
Length without tail0.41.12.41.3-1.0-1.1-1.01.0-0.6-0.4-0.41.51.5
Times rat made contact with spout0.70.83.31.8-0.9-0.8-0.40.4-0.2-0.5-0.51.4-0.7
Lifetime Intake0.30.30.60.6-0.6-0.5-0.70.7-0.5-0.3-0.30.50.8
Liver weight, left2.03.35.80.21.51.41.8-1.81.92.42.4-1.81.9
Liver weight, right0.20.31.01.0-0.7-0.7-0.30.3-0.20.30.30.50.5
Locomotor activity0.10.20.70.6-0.8-0.70.00.0-0.20.30.30.4-0.4
Locomotor testing distance1.22.24.11.0-2.0-2.0-1.51.5-1.4-1.3-1.31.8-0.0
Locomotor testing rearing0.10.20.7-0.2-0.3-0.2-0.40.4-0.2-0.1-0.10.70.8
Locomotion in novel chamber0.50.61.51.10.80.90.6-0.61.20.40.4-0.50.6
Locomotion in novel chamber post-restriction0.30.52.1-1.40.30.30.1-0.2-0.10.40.4-0.71.2
Fecal boli incidents, locomotor time 10.50.84.8-2.2-0.7-0.5-0.50.5-0.7-0.7-0.70.40.4
Change in fecal boli incidents, locomotor task0.30.30.4-0.4-0.3-0.3-0.60.6-0.5-0.6-0.60.60.2
Time >=10cm from walls, locomotor time 10.70.72.8-0.8-0.2-0.3-0.90.9-0.3-0.9-0.90.61.7
Bouts of movement, locomotor time 11.11.25.8-2.4-0.6-0.7-0.90.9-1.1-0.9-0.90.31.2
Total resting periods, locomotor time 11.61.84.2-2.0-1.2-1.3-1.41.4-1.5-1.2-1.20.61.3
Rest time, locomotor task time 12.02.54.0-1.6-1.2-1.3-1.91.8-1.5-2.0-2.00.91.1
Distance moved, locomotor task time 10.50.81.70.60.40.51.0-1.00.71.31.3-0.6-1.0
Vertical activity count, locomotor time 10.51.22.91.70.50.71.2-1.11.21.21.2-0.9-1.0
Time >=10cm from walls, locomotor time 20.20.22.2-1.50.20.1-0.10.1-0.2-0.2-0.20.10.1
Bouts of movement, locomotor time 20.30.64.1-2.00.30.20.1-0.0-0.70.30.3-0.0-0.8
Total resting periods, locomotor time 20.30.54.3-2.10.20.2-0.00.1-0.70.20.20.1-0.6
Rest time, locomotor task time 21.21.52.4-1.2-0.9-0.8-1.51.5-1.3-1.6-1.61.00.4
Distance moved, locomotor task time 21.21.42.70.61.01.01.4-1.31.31.61.6-0.9-0.1
Vertical activity count, locomotor time 20.81.11.81.10.60.61.3-1.21.31.31.3-0.7-0.1
Light reinforcement 10.20.40.80.8-0.7-0.8-0.60.5-0.2-0.6-0.60.90.5
Light reinforcement 21.62.43.60.7-1.3-1.6-1.81.8-1.0-1.9-1.91.71.3
Bone: marrow area1.22.64.40.8-2.0-2.1-1.91.9-1.8-0.9-0.91.91.3
Bone: maximum diameter1.22.23.50.6-1.8-1.9-1.71.7-1.8-1.3-1.31.8-0.3
Bone: maximum force1.22.14.40.7-2.0-2.1-1.61.6-1.7-0.8-0.81.70.4
Bone: maximum moment1.22.24.21.3-1.9-2.0-1.61.6-1.5-0.9-0.91.70.2
Mean time between licks in bursts0.92.33.91.2-1.4-1.4-2.01.9-1.0-1.6-1.61.41.3
Mean num. licks in bursts0.30.51.2-0.0-0.7-0.7-0.50.5-0.7-0.8-0.80.9-1.1
Cd content in liver1.41.63.20.31.81.81.4-1.41.60.80.8-1.30.0
Co content in liver0.81.02.2-0.6-0.5-0.6-1.21.2-0.7-1.5-1.50.90.3
Cu content in liver0.40.43.6-1.9-0.0-0.1-0.20.1-0.6-0.2-0.20.10.3
Fe content in liver1.92.33.6-0.6-1.5-1.5-1.41.4-1.9-1.6-1.61.5-1.9
K content in liver0.80.81.6-0.20.70.61.0-1.00.91.31.3-0.70.9
Mg content in liver0.30.30.5-0.30.40.30.6-0.50.60.50.5-0.40.7
Mn content in liver0.10.10.4-0.0-0.6-0.5-0.10.1-0.30.10.10.4-0.1
Na content in liver2.52.74.2-0.82.02.01.6-1.61.91.41.4-2.01.1
Rb content in liver0.70.91.7-1.0-0.5-0.6-1.11.1-0.8-1.3-1.30.70.3
Se content in liver1.11.32.20.1-1.1-1.2-1.31.3-1.1-1.3-1.31.5-0.6
Sr content in liver0.60.53.41.8-0.2-0.2-0.20.20.0-0.2-0.20.0-1.4
Zn content in liver1.11.31.8-1.31.31.21.3-1.30.90.90.9-1.3-0.4
Bone: minimum diameter4.58.211.61.6-3.1-3.2-3.43.4-2.7-3.0-3.03.20.0
Time in familiar zone, hab. session 10.90.92.5-0.2-0.4-0.5-0.80.8-0.8-1.3-1.30.6-1.6
Time in novel zone, hab. session 11.11.12.1-0.11.00.91.3-1.20.91.41.4-1.30.0
Total zone transitions, hab. session 10.91.26.8-2.61.31.20.8-0.80.50.30.3-0.40.2
Total locomotion distance, hab. session 10.71.01.9-1.31.41.30.9-0.90.90.60.6-1.00.7
Locomotion velocity, hab. session 10.60.81.4-1.11.21.10.6-0.70.90.50.5-0.71.2
Time in familiar zone, hab. session 22.02.13.30.01.51.41.8-1.81.31.61.6-1.5-0.8
Time in novel zone, hab. session 23.23.24.90.3-1.8-1.7-2.22.2-1.7-2.2-2.21.8-0.1
Total zone transitions, hab. session 21.62.02.7-0.81.51.51.6-1.61.31.61.6-1.60.6
Total locomotion distance, hab. session 20.40.51.10.40.60.60.5-0.60.80.70.7-0.91.1
Locomotion velocity, hab. session 20.91.21.60.21.01.01.0-1.01.21.31.3-1.31.3
Novel to familiar place preference ratio0.50.51.3-0.70.20.30.6-0.60.11.11.1-0.21.2
Novelty place preference0.60.61.5-0.50.40.40.7-0.70.21.21.2-0.31.1
Time in novel zone, NPP test0.40.41.2-0.50.30.30.7-0.70.11.11.1-0.30.7
Total zone transitions, NPP test1.31.92.70.11.51.41.6-1.61.61.51.5-1.40.2
Total locomotion distance, NPP test0.40.50.90.10.80.80.8-0.81.00.70.7-0.80.3
Locomotion velocity, NPP test0.81.11.90.11.21.21.2-1.21.41.11.1-1.00.7
Intraocular pressure0.50.81.80.30.60.50.8-0.80.31.31.3-1.1-0.9
Delta distance traveled before/after self-admin1.31.32.80.7-0.9-0.9-0.91.0-1.0-1.5-1.51.3-1.7
Delta ambulatory time before/after self-admin0.70.92.00.7-0.8-0.8-0.60.7-0.8-0.9-0.91.2-1.4
Parametrial fat weight0.51.18.31.20.20.3-0.30.30.70.20.2-0.12.9
Pavlov. Cond. lever latency0.70.95.62.4-0.4-0.4-0.50.50.2-0.7-0.70.3-1.0
Pavlov. Cond. magazine entry latency1.51.93.7-0.91.91.91.6-1.61.41.21.2-1.3-0.0
Pavlov. Cond. change in total contacts0.80.81.2-0.80.90.91.0-1.00.51.11.1-1.0-0.0
Pavlov. Cond. index score1.41.73.0-1.71.51.41.4-1.40.91.31.3-1.10.7
Pavlov. Cond. latency score1.31.74.4-2.11.41.31.3-1.30.71.31.3-1.00.8
Pavlov. Cond. lever contacts0.40.52.6-1.60.50.50.5-0.50.10.60.6-0.30.7
Pavlov. Cond. magazine entry number1.31.63.20.9-1.8-1.7-1.41.4-1.2-1.0-1.01.20.1
Pavlov. Cond. intertrial magazine entries1.61.92.60.8-1.6-1.6-1.31.4-1.3-1.6-1.61.2-1.2
Pavlov. Cond. lever-magazine prob. diff.1.31.62.1-1.41.41.31.3-1.40.91.31.3-1.10.6
Pavlov. Cond. response bias0.70.81.2-1.11.11.01.0-1.00.70.90.9-0.80.4
Pavlov. Cond. lever latency2.02.73.7-0.41.81.81.8-1.81.81.91.9-1.80.7
Pavlov. Cond. magazine entry latency0.50.61.90.1-0.2-0.3-0.90.9-0.1-1.1-1.10.31.4
Pavlov. Cond. change in total contacts1.42.23.20.5-1.7-1.6-1.61.6-1.5-1.8-1.81.5-0.5
Pavlov. Cond. index score2.12.84.50.6-1.7-1.7-2.02.0-1.5-2.1-2.11.60.4
Pavlov. Cond. latency score1.82.44.00.4-1.5-1.5-1.91.9-1.4-2.0-2.01.50.4
Pavlov. Cond. lever contacts2.73.75.30.5-2.1-2.1-2.22.2-2.0-2.3-2.32.1-0.4
Pavlov. Cond. magazine entry number0.60.82.60.30.30.31.1-1.00.31.21.2-0.3-1.6
Pavlov. Cond. intertrial magazine entries0.60.96.90.9-0.5-0.5-0.00.1-0.5-0.3-0.30.5-2.6
Pavlov. Cond. lever-magazine prob. diff.2.43.15.00.5-1.8-1.8-2.12.1-1.6-2.2-2.21.70.5
Pavlov. Cond. response bias1.41.93.00.6-1.4-1.4-1.61.6-1.3-1.7-1.71.4-0.1
Time in closed arm before self-admin0.40.50.90.4-0.8-0.7-1.01.0-0.5-0.4-0.40.60.7
Time in closed arm after self-admin0.10.21.2-0.0-0.4-0.30.2-0.2-0.30.00.00.1-1.1
Time in open arm before self-admin1.71.93.7-0.31.91.91.4-1.41.61.31.3-1.10.8
Time in open arm after self-admin0.50.51.50.7-0.3-0.4-0.90.9-0.3-0.8-0.80.41.2
Bone: periosteal estimation2.14.56.61.1-2.4-2.5-2.62.6-2.2-1.9-1.92.40.7
Bone: periosteal perimeter2.13.65.10.8-2.2-2.3-2.22.2-2.0-1.9-1.92.1-0.3
Bone: post-yield work0.30.40.8-0.8-0.7-0.7-0.50.5-0.7-0.2-0.20.70.9
Progressive ratio test 1 active lever presses0.50.61.61.3-0.9-0.8-0.90.9-0.5-0.4-0.40.90.5
Progressive ratio test 1 breakpoint0.50.61.91.4-0.8-0.8-0.90.9-0.5-0.3-0.30.80.4
Progressive ratio test 1 inactive lever presses0.10.21.10.8-0.00.10.1-0.1-0.0-0.1-0.1-0.0-1.0
Progressive ratio test 2 active lever presses0.70.82.31.2-0.9-0.7-1.11.0-0.3-0.5-0.50.61.5
Progressive ratio test 2 breakpoint0.80.92.21.2-1.0-0.8-1.11.1-0.4-0.5-0.50.71.5
Progressive ratio test 2 inactive lever presses0.10.10.30.6-0.4-0.2-0.40.4-0.1-0.4-0.40.30.1
Incentive Sensitization - Responses0.60.92.20.80.70.80.5-0.51.20.90.9-1.01.5
Incentive Sensitization - Breakpoint0.70.82.40.80.70.80.5-0.51.20.90.9-1.01.6
Sum of active levers in priming session hrs 5-60.70.61.0-0.4-0.9-1.0-1.01.0-0.9-0.4-0.40.60.9
Progressive ratio0.40.60.9-1.0-1.0-0.8-0.70.7-0.8-0.7-0.70.90.7
Food seeking constrained by brief footshock0.40.51.91.4-0.4-0.4-0.80.8-0.2-0.4-0.40.80.9
Seeking ratio, punishment vs. effort0.20.32.81.70.40.2-0.10.10.40.20.2-0.1-0.1
Retroperitoneal fat weight0.52.15.61.71.51.50.8-0.92.10.90.9-0.92.4
Reaction time number correct0.30.53.01.4-0.2-0.30.4-0.30.10.20.20.1-1.7
Reaction time mean minus median1.43.45.1-2.22.02.11.8-1.81.51.71.7-1.81.8
Reaction time mean minus median AUC0.30.82.7-1.60.60.70.5-0.50.30.70.7-0.51.7
Reaction time num false alarms0.20.21.40.4-0.10.10.1-0.1-0.3-0.4-0.40.7-1.2
Reaction time num false alarms AUC0.20.31.70.50.30.40.4-0.40.1-0.1-0.10.3-1.3
Reaction time trials correct on left0.30.53.01.4-0.2-0.30.4-0.30.10.20.20.1-1.7
Reaction time trials on left0.30.63.01.4-0.1-0.20.5-0.40.10.30.30.0-1.7
Reaction time mean0.81.22.5-1.61.51.40.7-0.80.90.60.6-1.21.1
Reaction time mean AUC0.60.93.1-1.81.41.30.5-0.60.60.40.4-0.90.9
Median of all reaction times0.30.41.4-1.21.00.90.1-0.10.3-0.0-0.0-0.60.5
Reaction time omissions1.92.84.1-1.71.71.72.0-2.00.82.02.0-1.6-0.4
Reaction time false alarm rate0.00.00.1-0.30.20.40.1-0.1-0.0-0.2-0.20.3-0.0
Reaction time premature initiation rate0.50.72.71.4-0.9-0.7-0.60.5-0.10.40.40.01.6
Reaction time premature initiations0.30.53.01.7-0.8-0.8-0.30.3-0.10.40.4-0.00.6
Std. dev. reaction times1.83.35.6-2.42.12.11.7-1.71.41.61.6-1.81.5
Reaction time trials completed0.30.63.01.4-0.1-0.20.5-0.40.10.30.30.0-1.7
Reaction time trials AUC0.40.73.41.60.0-0.10.6-0.50.30.40.4-0.2-1.9
Run reversals in cocaine runway, females0.40.41.31.10.60.60.4-0.40.8-0.0-0.0-0.7-0.6
Run reversals in cocaine runway, males1.91.93.21.81.31.31.3-1.31.71.51.5-1.20.5
Latency to leave start box in cocaine runway0.50.63.3-1.80.60.70.5-0.50.20.10.1-0.6-0.5
Latency to leave start box in cocaine runway, F0.40.42.1-1.50.50.60.6-0.60.40.10.1-0.5-0.6
Latency to leave start box in cocaine runway, M0.80.71.4-1.21.01.00.7-0.70.60.70.7-1.10.4
Std. dev. time between licks in bursts2.83.84.92.0-2.1-2.1-2.22.2-1.6-2.1-2.12.0-0.4
Total sessions with >9 infusions1.01.22.41.6-1.3-1.2-1.21.2-1.0-0.6-0.61.30.1
Short access day 1 total inactive lever presses0.30.40.9-0.6-0.8-0.7-0.30.3-1.0-0.2-0.20.7-0.7
Short access day 10 total inactive lever presses0.10.20.5-0.7-0.2-0.2-0.30.3-0.5-0.7-0.70.3-0.6
Short access day 1 total infusions0.40.51.00.5-1.0-0.9-0.80.8-0.9-0.5-0.50.8-0.1
Short access day 10 total infusions0.50.61.11.0-0.9-0.8-1.01.0-0.7-0.5-0.50.70.5
Short access total infusions0.70.91.40.5-1.2-1.0-1.21.1-1.0-0.9-0.90.90.2
Short access day 1 locomotion3.24.05.71.2-2.3-2.3-2.42.4-2.1-2.0-2.02.1-0.2
Short access day 10 total locomotion1.01.85.82.4-1.4-1.4-1.41.4-0.8-0.8-0.81.30.6
Short access total locomotion3.94.76.62.3-2.5-2.5-2.62.6-2.0-1.8-1.82.30.4
One hour access (0.3 mA shock)0.50.52.71.10.30.4-0.60.50.7-0.0-0.0-0.21.6
Compulsive drug intake1.11.31.9-1.11.41.31.4-1.41.00.80.8-1.2-0.7
One hour access (shock baseline)0.20.31.51.2-0.10.0-0.50.50.3-0.1-0.1-0.01.2
Social response proportion1.01.14.1-2.01.31.30.6-0.70.80.10.1-1.20.7
Social responses0.81.02.9-1.7-0.8-0.7-0.90.9-1.2-1.0-1.00.70.9
Social time0.60.86.0-2.50.60.60.3-0.30.00.30.3-0.51.0
Soleus weight0.71.93.70.71.31.31.2-1.31.91.51.5-1.41.5
Bone: stiffness0.40.72.6-0.7-1.0-0.9-0.40.3-0.70.50.50.71.6
Tibialis anterior weight0.20.71.60.21.21.10.3-0.41.20.40.4-1.01.2
Time to tail flick, vehicle, before self-admin1.21.32.01.00.90.81.2-1.21.11.41.4-1.4-0.4
Time to tail flick, vehicle, after self-admin1.41.82.90.21.41.41.4-1.41.51.71.7-1.40.5
Time to tail flick, test, before self-admin0.20.20.50.70.30.40.2-0.20.50.10.1-0.2-0.6
Time to tail flick, test, after self-admin1.21.32.31.51.41.31.0-1.01.40.40.4-1.1-1.3
Delta time to tail flick, vehicle, before/after SA0.50.50.7-0.70.80.80.8-0.80.60.70.7-0.40.1
Delta time to tail flick, test, before/after SA0.90.91.81.01.11.10.9-0.91.40.60.6-1.20.4
Tibia length1.95.417.54.2-2.2-2.2-2.62.5-1.2-1.9-1.92.10.8
Ambulatory time before self-admin0.30.42.70.80.30.0-0.30.30.60.40.4-0.31.6
Ambulatory time after self-admin0.20.21.61.30.1-0.3-0.40.40.2-0.2-0.20.1-0.2
Bone: tissue strength0.40.52.21.5-0.5-0.6-0.60.6-0.2-0.5-0.50.5-0.4
Total heroin consumption0.40.41.10.31.11.00.0-0.10.80.30.3-0.90.8
Bone: trabecular number1.42.47.3-2.70.60.61.5-1.50.12.12.1-0.91.3
Bone: trabecular spacing1.01.33.81.9-0.0-0.1-0.70.80.2-1.6-1.60.5-1.6
Bone: trabecular thickness0.60.82.2-1.5-0.9-1.0-0.40.4-1.30.40.40.61.0
Bone: trabecular tissue density0.40.54.90.40.20.20.3-0.30.0-0.3-0.30.0-2.2
Water consumed over 24 hours0.20.30.90.60.50.50.6-0.60.60.10.10.2-1.0
Number of responses in last shaping day2.83.14.60.7-2.1-2.1-2.12.1-2.0-1.6-1.61.80.4