Hub : Genes

Notum

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Notum 0.21 0.13 3.9e-03 0.06 0.03 0.04 0.04 1.6e-02 8.2e-02 3.4e-02 5.1e-02
2 Liver mRNA stability Notum 0.02 0.02 3.4e-03 0.02 0.02 0.02 0.02 9.1e-04 2.9e-03 4.1e-03 1.5e-03
3 BLA gene expression Notum 0.18 0.11 3.8e-06 0.13 0.1 0.11 0.11 2.0e-07 4.4e-06 2.4e-06 1.1e-06
4 OFC gene expression Notum 0.27 0.15 6.3e-04 0.14 0.02 0.08 0.12 3.0e-04 1.4e-01 5.6e-03 7.0e-04
5 RMTg gene expression Notum 0.19 0.13 4.7e-03 0.07 0.04 0.03 0.06 5.7e-03 2.8e-02 5.7e-02 9.8e-03
6 NAcc gene expression Notum 0.09 0.05 8.4e-08 0.07 0.06 0.05 0.06 4.8e-09 1.2e-07 8.3e-07 5.7e-08
7 LHb gene expression Notum 0.24 0.14 2.8e-03 0.08 0.09 0.11 0.06 6.9e-03 4.2e-03 1.6e-03 1.3e-02
8 pVTA gene expression Notum 0.17 0.1 1.7e-05 0.1 0.09 0.09 0.08 4.3e-05 7.5e-05 7.3e-05 2.6e-04
9 Liver gene expression Notum 0.13 0.07 7.0e-13 0.1 0.11 0.1 0.1 4.7e-11 3.4e-12 3.8e-11 4.5e-11
10 Adipose gene expression Notum 0.04 0.03 6.6e-03 0.01 0.01 0.01 0.01 6.9e-03 1.6e-02 1.5e-02 1.3e-02
11 PL gene expression Notum 0.27 0.14 0.0e+00 0.18 0.19 0.2 0.19 1.3e-19 7.2e-21 8.1e-22 3.5e-20
12 Brain gene expression Notum 0.18 0.09 1.0e-13 0.15 0.15 0.14 0.15 1.9e-13 9.3e-14 2.0e-13 4.3e-14
13 Brain mRNA stability Notum 0.03 0.02 7.9e-03 0.04 0.02 0.06 0.04 5.0e-05 3.7e-03 1.7e-06 1.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.40.61.3-0.70.1-1.1-0.9-0.9-1.2-0.7-0.80.4-0.9-0.80.8-0.3
Area under the delay curve0.80.81.71.11.10.91.11.20.80.60.80.60.70.8-0.51.3
BMI with tail0.72.35.2-2.3-0.2-2.0-1.5-1.6-1.3-2.2-1.60.3-1.4-1.91.2-0.8
BMI without tail7.014.524.5-5.0-0.5-4.4-3.9-4.0-4.3-4.4-4.21.2-4.4-4.14.1-1.7
Body weight1.76.911.3-3.2-2.6-3.4-2.8-2.7-2.7-2.2-2.8-1.2-2.5-2.82.3-2.6
Weight adjusted by age1.31.54.0-2.0-1.6-1.2-1.1-1.3-0.6-1.5-0.6-1.1-0.3-0.8-0.0-1.9
Bone surface0.10.20.30.1-0.6-0.5-0.5-0.4-0.60.4-0.4-0.3-0.4-0.30.3-0.4
Bone volume0.20.40.9-0.5-0.4-0.8-0.7-0.7-0.9-0.3-0.6-0.0-0.7-0.60.6-0.4
Breakpoint value in progressive ratio session0.70.82.0-0.7-1.40.40.60.70.8-0.20.7-1.40.80.4-0.8-1.4
Number of licking bursts0.50.50.9-0.10.4-0.9-0.9-0.9-0.9-0.2-1.00.6-0.9-0.70.80.5
Context. condit. distance diff. score3.34.05.3-2.21.1-2.1-2.3-2.3-1.9-2.3-2.31.6-2.1-2.32.2-0.1
Locomotion velocity, session 13.43.75.52.20.02.02.32.32.02.12.3-0.82.22.1-2.20.4
Locomotion distance, session 10.70.94.40.42.10.0-0.0-0.0-0.1-0.10.01.9-0.20.10.31.9
Locomotion velocity, session 22.63.06.42.51.42.11.71.71.82.01.70.61.51.6-1.41.7
Locomotion distance, session 20.50.82.1-0.21.3-0.6-0.7-0.7-0.9-0.5-0.71.4-0.9-0.70.91.1
Locomotion velocity, session 31.51.82.81.40.41.41.61.61.71.11.6-0.21.71.5-1.50.4
Locomotion distance, session 31.21.32.11.21.21.21.21.21.50.81.10.61.21.1-1.01.3
Stereotopy head waving bouts, day 31.01.22.91.30.01.71.11.11.01.21.1-0.41.11.3-1.10.4
Stereotopy head waving duration, day 30.30.41.20.90.21.10.60.60.50.70.6-0.00.60.8-0.50.6
Locomotion velocity, session 70.20.20.80.20.80.30.30.30.5-0.10.10.60.30.1-0.30.9
Locomotion distance, session 71.11.46.0-0.32.4-0.5-0.4-0.40.1-1.0-0.52.2-0.4-0.70.61.9
Stereotopy head waving bouts, day 70.10.10.4-0.7-0.20.0-0.3-0.3-0.4-0.5-0.4-0.1-0.2-0.30.30.2
Stereotopy head waving duration, day 70.10.10.3-0.1-0.60.2-0.3-0.3-0.40.2-0.3-0.4-0.1-0.20.20.1
Locomotion velocity, session 80.91.12.8-0.51.6-0.6-0.9-0.9-0.9-0.9-1.11.7-1.1-1.01.20.6
Locomotion distance, session 84.97.29.2-2.52.1-2.8-2.9-2.9-2.7-2.9-2.92.8-2.9-2.93.00.9
Degree of sensitization distance1.61.62.4-1.30.4-1.5-1.5-1.4-1.4-1.5-1.50.7-1.4-1.61.3-0.4
Degree of sensitization stereotypy0.40.41.3-1.1-0.3-0.5-0.7-0.6-0.8-0.8-0.7-0.1-0.5-0.70.6-0.1
Conditioned locomotion3.74.47.4-2.4-0.7-2.5-2.3-2.3-2.7-2.0-2.30.2-2.3-2.22.2-1.1
Cocaine response after cond. corrected0.40.50.90.1-0.50.70.70.90.70.10.9-0.60.70.9-0.7-0.7
Cocaine response after cond. not corrected0.50.61.10.60.00.90.91.00.80.51.0-0.30.71.1-0.8-0.2
Cocaine response before conditioning0.30.41.40.81.20.2-0.1-0.1-0.00.6-0.11.1-0.2-0.10.21.2
Saline control response1.21.52.3-1.3-1.4-1.3-1.2-1.3-1.5-0.9-1.3-0.7-1.3-1.21.2-1.3
Bone: connectivity density0.50.81.2-0.10.9-0.8-1.1-1.1-1.0-0.2-1.11.1-1.1-0.91.10.5
Bone: cortical apparent density1.21.62.51.10.91.21.51.41.60.81.40.31.51.4-1.31.2
Bone: cortical area1.72.67.6-1.7-2.7-1.4-1.1-1.2-1.9-0.7-1.2-1.8-1.2-0.90.8-2.6
Bone: cortical porosity3.33.67.30.9-2.41.71.91.91.61.41.9-2.71.91.9-2.1-1.3
Bone: cortical porosity2.12.25.60.4-2.21.31.41.41.11.01.4-2.41.41.5-1.6-1.3
Bone: cortical thickness1.32.110.0-1.0-3.2-0.6-0.3-0.3-1.10.0-0.3-2.5-0.4-0.1-0.1-3.0
Bone: cortical thickness0.50.62.2-1.0-1.5-0.3-0.1-0.2-0.7-0.6-0.2-1.2-0.2-0.0-0.0-1.4
Bone: cortical tissue density1.41.93.01.31.01.31.61.61.70.81.50.41.61.5-1.41.4
Condit. Reinf. active minus inactive responses1.21.42.6-1.6-0.8-1.2-1.2-1.2-1.3-1.1-1.2-0.4-1.3-1.21.0-1.1
Condit. Reinf. active-inactive response ratio0.60.61.8-1.3-0.6-1.0-0.8-0.7-0.8-1.0-0.7-0.3-0.7-0.80.5-0.6
Condit. Reinf. active responses2.22.74.4-2.0-1.1-1.6-1.8-1.8-2.1-1.4-1.8-0.4-1.9-1.61.6-1.4
Condit. Reinf. inactive responses0.60.71.3-0.9-0.5-0.6-0.9-0.9-1.1-0.6-0.9-0.1-1.1-0.80.9-0.7
Incentive salience index mean1.11.32.1-1.4-0.6-1.2-1.3-1.3-1.4-0.9-1.3-0.1-1.4-1.31.1-0.7
Condit. Reinf. lever presses0.40.60.8-0.40.6-0.7-0.9-0.9-0.8-0.4-0.90.8-0.9-0.90.80.7
Condit. Reinf. active minus inactive responses0.50.61.1-0.7-0.5-0.8-0.8-0.8-1.0-0.4-0.9-0.1-1.0-0.90.9-0.8
Condit. Reinf. active-inactive response ratio0.60.62.4-0.4-1.5-0.3-0.4-0.4-0.90.1-0.4-1.1-0.6-0.30.3-1.6
Condit. Reinf. active responses0.40.61.0-1.00.1-0.8-0.7-0.7-0.9-0.9-0.80.4-0.8-0.90.9-0.5
Condit. Reinf. inactive responses0.20.31.1-0.61.1-0.2-0.1-0.00.1-0.7-0.20.8-0.0-0.40.30.5
Condit. Reinf. lever presses0.91.23.2-1.70.3-1.3-0.9-0.9-1.1-1.8-1.00.7-1.1-1.11.0-0.3
Condit. Reinf. lever reinforcers received0.81.12.6-1.60.3-1.1-0.9-0.9-1.1-1.5-1.00.6-1.0-1.11.1-0.5
Conditioned reinforcement - actives0.50.51.0-0.30.8-0.5-0.8-0.7-0.8-0.4-1.00.8-0.6-0.31.00.7
Conditioned reinforcement - inactives0.60.63.0-1.0-1.1-0.6-0.7-0.5-0.5-0.6-0.5-0.8-0.5-0.30.4-1.7
Conditioned locomotion0.10.10.3-0.10.2-0.5-0.4-0.4-0.3-0.1-0.60.2-0.2-0.10.60.2
Patch foraging indifference point 0 sec0.00.10.3-0.6-0.5-0.4-0.2-0.2-0.2-0.5-0.1-0.2-0.0-0.10.0-0.1
Patch foraging indifference point AUC0.10.10.3-0.20.2-0.2-0.1-0.1-0.5-0.4-0.50.3-0.4-0.10.6-0.2
Delay disc. indifference point, 0s delay0.10.10.70.10.30.10.10.10.0-0.10.10.10.2-0.0-0.10.9
Delay disc. indifference point, 16s delay1.01.04.4-0.32.1-0.6-0.5-0.3-0.2-0.9-0.31.8-0.3-0.40.51.8
Delay disc. indifference point, 2s delay0.40.51.20.50.30.71.01.00.70.40.7-0.10.60.7-0.51.1
Delay disc. indifference point, 24s delay3.33.24.82.01.12.12.02.12.21.72.00.21.92.0-1.80.9
Delay disc. indifference point, 4s delay0.60.61.71.30.30.91.21.20.30.90.60.10.40.8-0.40.7
Delay disc. indifference point, 8s delay1.21.22.41.50.21.31.41.51.21.21.1-0.41.01.1-1.00.3
Indifference point function ln k0.20.31.00.30.80.20.40.20.60.10.50.60.40.3-0.51.0
Indifference point function log k0.20.31.00.30.80.20.40.20.60.10.50.60.40.3-0.51.0
Patch foraging total patch changes 0 sec0.10.20.8-0.9-0.3-0.6-0.3-0.4-0.3-0.8-0.2-0.1-0.2-0.30.2-0.1
Patch foraging total patch changes 12 sec0.10.10.3-0.0-0.60.20.40.50.00.10.2-0.40.20.4-0.2-0.3
Patch foraging total patch changes 18 sec0.70.82.1-1.10.6-1.3-0.9-0.8-1.0-1.5-0.70.9-0.7-0.80.80.2
Patch foraging total patch changes 24 sec0.60.82.4-1.6-0.5-1.3-0.9-0.8-0.7-1.4-0.4-0.2-0.5-0.60.4-1.0
Patch foraging total patch changes 6 sec0.10.21.2-0.2-1.10.30.20.2-0.20.10.0-0.8-0.00.40.0-0.6
Patch foraging time to switch 0 sec0.30.50.70.80.40.80.60.80.70.80.80.10.70.8-0.70.6
Patch foraging water rate 0 sec2.03.26.6-2.6-0.7-1.9-1.8-2.0-1.8-2.2-1.9-0.0-1.7-2.01.7-1.6
Patch foraging water rate 12 sec1.11.72.8-1.60.6-1.5-1.3-1.5-1.2-1.7-1.40.9-1.2-1.61.4-0.3
Patch foraging water rate 18 sec1.82.43.5-1.70.4-1.9-1.8-1.9-1.6-1.5-1.81.0-1.6-1.91.60.1
Patch foraging water rate 24 sec4.15.811.5-3.40.4-2.9-2.5-2.7-2.3-3.3-2.51.1-2.3-2.72.3-0.3
Patch foraging water rate 6 sec0.50.71.5-0.70.5-1.2-1.0-1.1-0.6-0.7-1.00.7-0.8-1.20.9-0.3
Seeking ratio, delayed vs. immediate footshock0.80.92.0-1.1-0.7-1.0-0.9-0.9-1.4-0.8-1.1-0.3-1.3-0.71.0-0.7
Distance traveled before self-admin0.80.83.6-0.8-1.90.00.00.30.6-0.20.0-1.70.6-0.3-0.8-1.5
Distance traveled after self-admin1.01.12.3-1.5-0.1-1.4-1.1-1.0-1.0-1.4-1.00.3-1.0-1.30.9-0.6
Extensor digitorum longus weight1.03.86.1-2.20.9-2.3-2.0-2.1-1.9-2.5-2.11.8-2.0-2.12.10.6
Bone: elastic displacement0.30.42.3-0.4-1.5-0.3-0.10.0-0.4-0.10.0-1.2-0.00.1-0.2-0.9
Bone: elastic work2.32.915.0-0.8-3.9-0.10.30.4-0.30.20.4-3.30.30.3-0.8-3.2
Bone: endosteal estimation0.61.41.9-1.20.9-1.4-1.2-1.2-1.3-1.4-1.21.2-1.2-1.21.30.4
Bone: endosteal perimeter0.20.51.2-0.6-1.0-0.8-0.6-0.6-0.8-0.3-0.6-0.5-0.6-0.60.5-1.1
Epididymis fat weight1.02.44.7-1.9-0.3-2.2-1.7-1.7-1.4-1.7-1.90.2-1.4-2.01.4-0.7
Delta time in closed arm before/after self-admin0.30.30.60.60.7-0.3-0.4-0.5-0.60.4-0.20.6-0.50.10.40.8
Delta time in open arm before/after self-admin0.40.31.4-1.20.2-0.5-0.7-0.50.1-1.2-0.30.30.0-0.80.0-0.0
Diff in mean of infusions in LGA sessions0.20.20.80.20.10.40.40.60.80.30.4-0.20.90.3-0.70.2
Delay discount exponential model param1.31.42.6-1.5-1.0-1.3-1.5-1.6-1.1-1.0-1.1-0.4-1.0-1.20.9-1.2
Extinction: sum of active levers before priming1.21.23.81.10.31.00.91.12.00.81.1-0.31.70.5-1.40.5
Active lever presses in extinction session 61.51.43.60.1-0.80.91.11.11.90.31.5-1.21.71.0-1.7-0.6
Bone: final force1.72.86.2-2.2-2.5-1.6-1.4-1.4-1.8-1.2-1.4-1.5-1.4-1.31.1-2.2
Bone: final moment1.82.98.3-2.3-2.9-1.5-1.2-1.3-1.8-1.2-1.2-1.9-1.3-1.11.0-2.4
Food consumed during 24 hour testing period0.20.30.9-0.9-0.4-0.4-0.4-0.5-0.1-0.6-0.5-0.2-0.5-0.80.30.2
Glucose7.210.917.32.6-0.93.73.93.94.22.63.9-2.24.13.5-4.0-0.5
Heart weight0.20.30.6-0.8-0.6-0.4-0.5-0.5-0.4-0.6-0.3-0.4-0.2-0.60.1-0.7
Delay discount hyperbolic model param1.31.42.6-1.5-1.0-1.3-1.5-1.6-1.1-1.0-1.1-0.4-1.0-1.10.8-1.3
Intermittent access intake day 1-15 change0.30.31.2-0.7-1.1-0.2-0.3-0.2-0.6-0.4-0.5-0.7-0.5-0.30.3-0.9
Intermittent access intake escalation0.30.30.6-0.8-0.8-0.2-0.4-0.4-0.8-0.5-0.6-0.4-0.7-0.30.5-0.5
Intermittent access intake escalation 20.70.74.0-0.8-2.00.30.10.1-0.2-0.10.0-1.70.00.2-0.3-1.3
Intermitt. access day 1 inactive lever presses0.60.73.7-0.9-1.4-0.6-0.2-0.20.1-0.5-0.1-1.1-0.2-0.5-0.2-1.9
Intermitt. access day 15 inactive lever presses1.21.32.7-1.6-0.1-1.5-1.6-1.5-1.1-1.4-1.10.2-1.2-1.10.8-0.3
Intermitt. access escalation Index1.91.63.1-1.20.6-1.4-1.7-1.7-1.4-1.2-1.40.9-1.5-1.21.40.2
Intermittent access day 1 total infusions0.20.20.5-0.3-0.3-0.6-0.5-0.3-0.6-0.2-0.7-0.0-0.6-0.50.7-0.5
Intermittent access day 15 total infusions0.50.61.1-0.9-0.4-0.7-0.8-0.7-1.0-0.8-1.0-0.0-0.9-0.70.9-0.4
Intermittent access terminal intake (last 3 days)0.50.50.9-0.9-0.8-0.6-0.8-0.6-1.0-0.5-0.9-0.5-0.7-0.50.9-0.6
Intermittent access total infusions0.40.40.9-0.6-0.3-0.6-0.7-0.6-0.9-0.5-0.9-0.0-0.8-0.60.9-0.5
Intermittent access day 1 locomotion0.40.50.9-0.70.1-0.9-0.7-0.7-0.7-0.6-0.90.3-0.8-0.60.9-0.2
Intermittent access day 15 total locomotion0.10.20.5-0.1-0.70.00.00.1-0.40.2-0.4-0.5-0.30.00.5-0.6
Intermittent access total locomotion0.20.20.5-0.4-0.4-0.5-0.5-0.4-0.5-0.2-0.7-0.2-0.6-0.40.7-0.6
Intermittent access standard deviation1.81.93.10.7-1.11.61.61.81.61.01.4-1.41.61.2-1.7-0.1
Left kidney weight0.20.62.21.2-0.70.80.70.70.31.50.4-0.80.40.9-0.5-0.4
Right kidney weight0.10.31.61.30.00.50.30.10.11.2-0.1-0.10.10.40.0-0.1
Cocaine induced anxiety2.93.317.4-1.4-3.4-0.2-0.10.10.8-0.50.5-3.00.6-0.2-1.1-4.2
Post-drug Anxiety1.11.36.9-0.6-1.70.10.40.70.9-0.10.8-1.60.70.4-1.1-2.6
Baseline Anxiety2.62.89.42.03.11.11.11.10.81.20.92.20.61.4-0.52.9
Tail length3.611.018.3-3.7-1.9-3.7-3.8-3.7-4.3-2.7-3.7-0.1-3.9-3.23.7-2.3
Length with tail0.62.37.2-1.0-2.7-1.6-1.5-1.2-1.5-0.2-1.2-1.8-1.1-1.01.1-2.2
Length without tail2.55.48.72.8-1.52.22.22.32.42.92.5-2.22.72.3-2.6-0.4
Times rat made contact with spout0.91.13.70.2-1.90.80.90.90.70.80.9-1.90.70.6-1.0-1.0
Lifetime Intake0.10.10.4-0.2-0.1-0.3-0.5-0.3-0.5-0.2-0.60.1-0.4-0.30.6-0.2
Liver weight, left1.01.62.81.1-0.91.21.41.31.41.11.4-1.31.71.2-1.6-0.3
Liver weight, right0.40.71.9-0.1-1.4-0.9-0.7-0.9-0.80.5-0.8-0.9-0.8-0.90.4-1.0
Locomotor activity0.30.51.10.40.60.40.80.80.70.30.90.30.70.8-0.81.1
Locomotor testing distance0.30.52.0-0.11.3-0.00.20.30.4-0.50.50.90.40.4-0.51.4
Locomotor testing rearing0.20.31.0-0.41.0-0.3-0.4-0.2-0.1-0.70.00.8-0.1-0.1-0.00.8
Locomotion in novel chamber0.30.31.0-0.31.0-0.7-0.6-0.60.2-0.6-0.40.80.2-0.80.10.3
Locomotion in novel chamber post-restriction0.91.03.0-0.5-1.4-0.5-0.7-0.7-1.3-0.1-1.2-0.7-1.3-0.81.0-1.7
Fecal boli incidents, locomotor time 10.20.20.80.30.90.10.40.40.20.10.20.70.00.20.00.8
Change in fecal boli incidents, locomotor task3.33.25.11.8-0.52.12.32.11.71.92.0-1.02.02.1-1.9-0.3
Time >=10cm from walls, locomotor time 11.61.63.2-0.40.7-1.3-1.4-1.4-1.7-0.6-1.61.1-1.8-1.41.60.1
Bouts of movement, locomotor time 10.80.91.91.20.81.11.11.01.40.61.10.41.20.9-0.90.3
Total resting periods, locomotor time 11.51.62.71.60.61.51.51.41.61.11.40.11.51.3-1.20.3
Rest time, locomotor task time 10.70.81.40.9-0.40.81.21.11.00.91.0-0.60.91.0-0.9-0.5
Distance moved, locomotor task time 10.70.81.5-0.9-0.0-1.2-1.1-1.0-1.0-1.0-1.00.3-0.8-1.20.80.4
Vertical activity count, locomotor time 12.22.34.1-1.60.4-1.9-1.9-1.8-1.4-1.7-1.70.8-1.3-2.01.40.9
Time >=10cm from walls, locomotor time 20.30.31.01.00.30.4-0.0-0.2-0.70.8-0.50.3-0.60.10.60.6
Bouts of movement, locomotor time 20.30.41.40.91.20.60.40.40.70.20.30.90.30.2-0.10.6
Total resting periods, locomotor time 20.30.31.80.71.30.3-0.0-0.00.30.0-0.11.1-0.1-0.10.30.6
Rest time, locomotor task time 20.10.10.60.80.20.20.50.40.40.70.10.10.20.1-0.10.2
Distance moved, locomotor task time 20.10.10.5-0.20.1-0.5-0.4-0.4-0.5-0.4-0.20.1-0.2-0.20.20.7
Vertical activity count, locomotor time 21.11.21.8-0.80.9-1.3-1.3-1.3-1.2-1.0-1.11.0-1.1-1.11.01.1
Light reinforcement 11.83.35.6-2.00.4-1.9-2.2-2.1-1.8-2.0-2.40.9-1.8-2.31.7-0.4
Light reinforcement 21.52.03.4-1.4-0.4-1.4-1.9-1.8-1.7-1.1-1.80.1-1.6-1.81.4-0.5
Bone: marrow area0.61.41.9-1.20.9-1.4-1.2-1.2-1.3-1.4-1.21.2-1.1-1.21.30.4
Bone: maximum diameter0.50.81.9-0.6-1.3-0.8-1.0-1.0-1.4-0.1-0.9-0.8-0.8-0.70.8-1.1
Bone: maximum force2.03.56.6-2.3-2.3-1.9-1.6-1.7-2.2-1.4-1.7-1.4-1.7-1.71.4-2.6
Bone: maximum moment2.13.67.7-2.4-2.7-1.8-1.5-1.6-2.1-1.4-1.6-1.7-1.6-1.51.2-2.8
Mean time between licks in bursts0.50.62.50.91.40.60.40.50.30.40.51.00.40.7-0.31.6
Mean num. licks in bursts0.81.02.0-0.1-1.31.01.11.11.10.31.1-1.40.90.7-1.0-0.9
Cd content in liver0.40.52.00.11.30.40.40.40.7-0.30.41.00.40.1-0.21.4
Co content in liver0.10.10.3-0.50.2-0.00.00.10.5-0.60.10.30.1-0.10.00.3
Cu content in liver1.31.52.80.8-1.41.11.41.41.41.21.3-1.71.11.0-1.3-0.8
Fe content in liver0.20.31.40.31.0-0.10.40.30.3-0.10.30.70.30.1-0.21.2
K content in liver2.01.93.7-1.1-0.1-1.3-1.7-1.7-1.8-0.9-1.80.4-1.9-1.41.7-0.6
Mg content in liver2.62.74.6-0.81.4-1.5-1.9-1.9-2.0-1.0-2.01.7-2.1-1.62.00.5
Mn content in liver0.10.10.40.3-0.40.20.0-0.2-0.20.6-0.1-0.4-0.2-0.00.1-0.4
Na content in liver0.00.00.10.4-0.00.1-0.00.00.30.40.1-0.10.20.1-0.3-0.3
Rb content in liver1.51.93.0-1.40.4-1.5-1.4-1.5-1.7-1.3-1.60.7-1.7-1.51.6-0.5
Se content in liver0.20.30.6-0.6-0.1-0.6-0.6-0.6-0.8-0.4-0.60.0-0.6-0.40.5-0.5
Sr content in liver3.02.74.21.3-1.21.91.81.91.61.41.9-1.61.92.1-2.0-0.4
Zn content in liver0.50.52.51.60.11.00.50.40.21.60.3-0.20.00.7-0.20.2
Bone: minimum diameter0.91.65.1-1.6-2.3-1.0-0.8-0.9-1.4-0.7-0.9-1.5-0.9-0.70.6-2.0
Time in familiar zone, hab. session 10.30.30.50.0-0.30.30.70.70.30.00.6-0.50.60.5-0.6-0.7
Time in novel zone, hab. session 10.10.10.3-0.10.2-0.1-0.5-0.5-0.0-0.1-0.50.4-0.4-0.40.50.3
Total zone transitions, hab. session 10.10.20.7-0.50.8-0.0-0.1-0.2-0.2-0.7-0.10.8-0.2-0.20.20.4
Total locomotion distance, hab. session 10.71.02.7-1.60.4-0.9-0.9-1.0-1.0-1.6-0.90.8-0.9-1.00.90.2
Locomotion velocity, hab. session 10.81.12.7-1.60.4-1.2-1.0-1.0-1.0-1.6-1.00.8-0.9-1.11.00.3
Time in familiar zone, hab. session 20.20.20.8-0.70.6-0.60.0-0.00.2-0.9-0.20.6-0.1-0.30.10.7
Time in novel zone, hab. session 20.10.10.60.80.20.6-0.00.0-0.20.70.10.10.10.20.0-0.1
Total zone transitions, hab. session 21.82.44.1-1.21.7-1.4-1.4-1.5-1.5-1.5-1.52.0-1.7-1.51.71.0
Total locomotion distance, hab. session 23.14.15.8-1.91.2-2.0-2.2-2.2-2.4-2.0-2.21.8-2.4-2.22.40.8
Locomotion velocity, hab. session 23.14.26.1-2.00.9-2.1-2.2-2.3-2.5-2.0-2.31.6-2.4-2.22.40.5
Novel to familiar place preference ratio1.01.04.5-0.8-2.10.30.20.3-0.0-0.00.4-1.90.40.3-0.5-1.9
Novelty place preference1.11.14.4-0.6-2.10.40.30.40.10.10.5-2.00.50.4-0.6-2.0
Time in novel zone, NPP test0.80.83.4-0.7-1.80.30.20.2-0.1-0.10.3-1.70.30.2-0.4-1.8
Total zone transitions, NPP test2.43.46.5-1.22.2-1.7-1.8-1.8-1.8-1.7-1.72.6-1.9-1.72.01.6
Total locomotion distance, NPP test3.85.26.7-2.01.9-2.2-2.5-2.5-2.4-2.2-2.52.4-2.5-2.42.61.2
Locomotion velocity, NPP test2.84.05.0-2.01.4-2.0-2.2-2.2-2.2-2.1-2.21.9-2.1-2.12.20.9
Intraocular pressure0.70.93.4-1.1-0.2-0.8-0.8-0.8-1.8-0.9-0.90.2-1.2-0.71.1-0.7
Delta distance traveled before/after self-admin0.91.02.5-0.71.5-1.0-0.8-0.9-1.0-1.1-0.61.6-0.9-0.61.00.8
Delta ambulatory time before/after self-admin0.80.83.50.01.9-0.5-0.4-0.6-0.7-0.6-0.21.8-0.7-0.10.81.2
Parametrial fat weight0.61.22.7-1.1-1.4-1.6-1.0-1.1-1.2-0.8-1.0-0.8-0.9-0.80.9-1.0
Pavlov. Cond. lever latency1.62.05.4-1.62.0-1.1-1.0-1.1-0.6-2.3-1.12.1-1.1-1.11.31.0
Pavlov. Cond. magazine entry latency1.21.66.3-0.1-2.50.30.70.80.20.80.8-2.30.70.6-1.1-2.1
Pavlov. Cond. change in total contacts1.61.73.30.5-1.71.11.31.41.11.01.4-1.81.41.4-1.5-0.8
Pavlov. Cond. index score0.91.15.70.0-2.4-0.10.10.2-0.31.00.2-2.10.20.1-0.5-1.7
Pavlov. Cond. latency score1.11.45.60.6-2.40.40.40.50.11.50.5-2.20.50.5-0.8-1.6
Pavlov. Cond. lever contacts0.50.62.00.8-1.40.40.30.4-0.01.40.4-1.30.40.4-0.6-0.7
Pavlov. Cond. magazine entry number2.12.67.6-0.42.8-0.9-1.2-1.3-0.8-1.2-1.32.8-1.3-1.11.72.1
Pavlov. Cond. intertrial magazine entries1.31.52.2-1.20.6-1.4-1.3-1.3-1.5-1.4-1.40.9-1.4-1.21.50.4
Pavlov. Cond. lever-magazine prob. diff.0.91.26.0-0.1-2.5-0.20.10.2-0.30.80.2-2.10.20.1-0.6-1.8
Pavlov. Cond. response bias1.51.86.20.4-2.50.60.81.00.41.21.0-2.40.90.8-1.3-1.8
Pavlov. Cond. lever latency1.92.55.62.3-0.41.91.71.51.62.41.6-0.91.51.8-1.50.3
Pavlov. Cond. magazine entry latency0.91.03.6-0.81.9-0.6-0.5-0.4-0.2-1.4-0.41.8-0.5-0.60.51.3
Pavlov. Cond. change in total contacts0.91.24.2-1.71.1-1.1-0.9-0.8-0.6-2.0-0.81.2-0.7-1.10.80.3
Pavlov. Cond. index score1.01.34.6-1.81.0-1.2-0.9-0.8-0.7-2.2-0.81.2-0.8-1.00.80.3
Pavlov. Cond. latency score1.21.54.7-1.91.1-1.3-1.1-1.0-0.9-2.2-1.01.3-1.0-1.11.00.4
Pavlov. Cond. lever contacts2.43.36.3-2.50.4-2.2-2.0-1.9-1.8-2.5-1.91.0-1.8-2.11.8-0.2
Pavlov. Cond. magazine entry number0.91.23.21.2-1.80.80.70.60.41.70.5-1.80.60.7-0.6-1.0
Pavlov. Cond. intertrial magazine entries0.81.02.0-0.9-0.8-1.0-1.1-1.1-1.4-0.5-1.2-0.4-1.1-0.91.2-1.0
Pavlov. Cond. lever-magazine prob. diff.1.01.24.6-1.81.1-1.1-0.8-0.7-0.7-2.1-0.71.3-0.7-0.90.70.3
Pavlov. Cond. response bias1.42.04.8-2.00.8-1.6-1.4-1.3-1.2-2.2-1.31.1-1.2-1.61.20.2
Time in closed arm before self-admin0.91.02.10.6-0.81.51.31.31.00.71.0-1.01.00.8-1.0-0.7
Time in closed arm after self-admin2.52.64.12.0-0.82.01.81.81.51.91.8-1.21.51.7-1.7-0.4
Time in open arm before self-admin0.40.41.00.71.0-0.5-0.4-0.6-0.50.6-0.40.8-0.40.20.51.0
Time in open arm after self-admin0.40.40.9-0.41.0-0.8-0.6-0.6-0.3-0.6-0.50.9-0.3-0.60.40.8
Bone: periosteal estimation1.02.14.0-1.8-1.3-1.7-1.4-1.5-2.0-1.2-1.4-0.5-1.4-1.31.3-1.4
Bone: periosteal perimeter0.81.47.4-0.2-2.7-0.20.0-0.0-0.60.6-0.0-2.20.00.1-0.3-2.3
Bone: post-yield work0.50.71.0-0.70.8-0.7-0.9-0.9-1.0-0.8-0.91.0-0.9-0.91.00.1
Progressive ratio test 1 active lever presses0.70.81.3-0.9-0.5-1.1-1.0-0.9-0.9-0.6-1.2-0.1-0.9-0.91.1-0.8
Progressive ratio test 1 breakpoint0.91.01.6-1.0-0.6-1.2-1.2-1.0-1.0-0.7-1.2-0.2-0.9-1.11.1-1.0
Progressive ratio test 1 inactive lever presses1.92.13.3-1.8-0.8-1.8-1.7-1.7-1.2-1.6-1.7-0.2-1.3-1.71.4-1.1
Progressive ratio test 2 active lever presses0.20.20.4-0.2-0.4-0.3-0.1-0.0-0.60.1-0.5-0.2-0.6-0.10.7-0.6
Progressive ratio test 2 breakpoint0.30.41.0-0.4-0.2-0.5-0.5-0.3-1.0-0.2-0.90.1-0.9-0.41.0-0.3
Progressive ratio test 2 inactive lever presses0.10.20.7-0.4-0.7-0.1-0.10.0-0.3-0.1-0.3-0.6-0.30.10.2-0.8
Incentive Sensitization - Responses0.10.10.5-0.0-0.4-0.20.00.0-0.70.1-0.1-0.1-0.7-0.10.4-0.7
Incentive Sensitization - Breakpoint0.10.10.50.1-0.4-0.10.10.2-0.50.2-0.0-0.2-0.50.00.3-0.7
Sum of active levers in priming session hrs 5-60.90.93.1-1.3-1.50.20.60.50.3-0.80.7-1.40.40.3-0.5-1.8
Progressive ratio0.20.30.80.50.50.40.40.40.60.40.50.20.60.6-0.50.9
Food seeking constrained by brief footshock0.50.71.50.4-0.40.71.21.01.20.61.0-0.71.10.6-0.80.3
Seeking ratio, punishment vs. effort0.10.20.4-0.7-0.2-0.4-0.2-0.3-0.3-0.6-0.3-0.0-0.4-0.60.5-0.5
Retroperitoneal fat weight2.27.113.5-3.5-2.3-3.7-2.9-2.7-2.3-2.7-2.9-1.1-2.2-3.02.2-2.2
Reaction time number correct6.28.912.3-2.82.6-3.2-3.5-3.4-2.9-3.4-3.03.2-2.9-3.13.01.2
Reaction time mean minus median0.60.91.61.0-0.60.90.81.01.11.10.9-0.91.30.8-1.0-0.1
Reaction time mean minus median AUC0.10.10.60.8-0.20.2-0.10.10.30.80.1-0.30.50.0-0.30.0
Reaction time num false alarms0.20.21.00.00.41.00.60.40.5-0.00.50.20.40.7-0.40.4
Reaction time num false alarms AUC0.30.40.90.30.90.90.60.30.40.00.50.60.30.8-0.30.9
Reaction time trials correct on left6.28.912.3-2.82.6-3.2-3.5-3.4-2.9-3.4-3.03.2-2.9-3.13.01.2
Reaction time trials on left6.49.212.8-2.82.6-3.3-3.6-3.4-3.0-3.4-3.03.2-3.0-3.13.11.2
Reaction time mean0.30.40.7-0.8-0.2-0.8-0.8-0.7-0.5-0.8-0.80.0-0.3-0.80.4-0.2
Reaction time mean AUC0.60.81.5-1.00.3-1.1-1.2-1.0-0.8-1.1-1.20.5-0.7-1.10.80.1
Median of all reaction times0.60.81.4-1.20.0-1.1-1.1-1.0-0.8-1.2-1.10.3-0.7-1.10.8-0.2
Reaction time omissions0.50.61.4-1.00.3-0.9-1.2-0.9-0.6-1.0-0.70.5-0.6-0.60.60.7
Reaction time false alarm rate2.23.16.31.6-0.52.52.32.01.81.71.9-1.11.72.2-1.80.2
Reaction time premature initiation rate0.60.81.70.30.71.11.31.30.40.21.20.40.41.2-0.70.9
Reaction time premature initiations1.11.64.2-1.22.0-0.7-0.7-0.6-1.3-1.7-0.52.1-1.2-0.61.01.4
Std. dev. reaction times0.10.10.40.20.50.0-0.00.20.5-0.00.10.30.5-0.0-0.30.6
Reaction time trials completed6.49.212.8-2.82.6-3.3-3.6-3.4-3.0-3.4-3.03.2-3.0-3.13.11.2
Reaction time trials AUC6.49.213.0-2.82.6-3.3-3.6-3.5-3.0-3.4-3.03.2-3.0-3.13.11.2
Run reversals in cocaine runway, females0.50.51.7-0.51.3-0.3-0.5-0.4-0.3-0.9-0.21.2-0.5-0.60.50.5
Run reversals in cocaine runway, males0.90.83.40.2-1.80.50.50.50.40.80.4-1.70.50.5-0.6-1.4
Latency to leave start box in cocaine runway0.20.20.80.30.7-0.1-0.10.1-0.3-0.1-0.20.8-0.3-0.20.20.9
Latency to leave start box in cocaine runway, F0.80.82.3-0.21.4-0.5-0.7-0.7-0.9-0.6-1.01.5-0.9-0.60.91.1
Latency to leave start box in cocaine runway, M0.10.10.30.6-0.60.40.40.30.00.60.2-0.50.10.1-0.1-0.0
Std. dev. time between licks in bursts4.95.87.7-2.21.4-2.7-2.8-2.7-2.5-2.6-2.72.1-2.6-2.72.60.7
Total sessions with >9 infusions0.20.20.60.80.70.2-0.2-0.10.00.5-0.10.50.00.40.20.5
Short access day 1 total inactive lever presses0.70.71.5-0.31.2-0.9-0.8-0.7-0.9-0.5-1.01.2-1.0-0.61.00.7
Short access day 10 total inactive lever presses1.21.34.3-1.2-1.9-0.9-0.8-0.8-1.0-0.6-0.9-1.1-1.1-1.00.5-2.1
Short access day 1 total infusions0.70.81.51.21.00.80.60.71.10.80.80.51.00.9-0.61.2
Short access day 10 total infusions0.20.20.8-0.2-0.9-0.0-0.3-0.2-0.10.1-0.5-0.6-0.1-0.20.5-0.9
Short access total infusions0.00.00.10.30.00.1-0.2-0.00.10.2-0.20.00.00.00.2-0.1
Short access day 1 locomotion0.80.92.11.4-0.01.10.80.90.91.40.8-0.31.01.1-0.70.5
Short access day 10 total locomotion0.91.01.81.1-0.70.91.11.21.01.41.0-1.01.01.1-0.90.0
Short access total locomotion1.01.02.71.6-0.11.11.11.20.91.60.6-0.40.91.1-0.60.4
One hour access (0.3 mA shock)1.01.22.0-1.2-0.5-1.0-1.1-0.9-1.3-0.9-1.40.0-1.3-1.01.3-1.3
Compulsive drug intake0.60.61.6-1.3-0.2-1.0-0.8-0.8-0.5-1.2-0.90.1-0.6-1.10.5-0.4
One hour access (shock baseline)0.30.30.9-0.00.3-0.2-0.6-0.5-0.80.1-0.70.5-0.9-0.10.9-0.1
Social response proportion0.20.20.8-0.10.9-0.2-0.2-0.2-0.1-0.20.10.8-0.1-0.00.20.8
Social responses0.20.31.9-0.00.6-0.6-0.5-0.40.1-0.0-0.20.60.0-0.30.21.4
Social time0.10.10.7-0.10.6-0.2-0.2-0.3-0.3-0.2-0.20.7-0.3-0.20.10.8
Soleus weight0.61.72.6-1.2-1.2-1.3-1.5-1.6-1.3-0.8-1.6-0.4-1.5-1.51.3-0.9
Bone: stiffness0.50.71.2-0.9-0.5-1.0-0.8-0.9-1.1-0.6-1.0-0.1-0.9-1.00.9-0.8
Tibialis anterior weight0.30.91.4-0.50.4-1.0-1.0-1.1-1.0-0.6-1.10.9-1.2-1.21.20.2
Time to tail flick, vehicle, before self-admin0.10.10.30.00.1-0.0-0.2-0.5-0.30.1-0.40.2-0.4-0.50.6-0.2
Time to tail flick, vehicle, after self-admin1.11.23.11.61.41.10.80.80.71.10.80.90.71.0-0.71.7
Time to tail flick, test, before self-admin0.20.20.50.4-0.60.60.30.3-0.20.50.6-0.5-0.20.70.1-0.5
Time to tail flick, test, after self-admin0.30.30.60.70.30.30.30.10.60.70.70.10.60.8-0.40.5
Delta time to tail flick, vehicle, before/after SA0.40.41.70.11.1-0.4-0.4-0.3-0.4-0.3-0.21.0-0.3-0.00.21.3
Delta time to tail flick, test, before/after SA0.60.51.40.70.10.50.80.81.00.70.8-0.31.20.7-1.00.1
Tibia length2.15.927.5-1.3-5.2-0.8-0.7-0.8-1.50.1-0.8-4.0-0.8-0.60.2-5.0
Ambulatory time before self-admin1.01.14.4-1.2-2.1-0.1-0.4-0.10.3-0.5-0.3-1.70.3-0.6-0.4-1.9
Ambulatory time after self-admin0.40.51.2-1.1-0.2-0.9-0.8-0.7-0.5-0.9-0.70.1-0.6-0.90.5-0.4
Bone: tissue strength1.61.52.3-1.3-0.2-1.3-1.4-1.4-1.5-1.2-1.50.4-1.5-1.31.4-0.1
Total heroin consumption1.01.22.8-0.4-1.10.81.01.21.50.01.3-1.41.30.8-1.7-0.4
Bone: trabecular number0.10.10.30.20.2-0.5-0.3-0.3-0.50.2-0.20.2-0.3-0.20.2-0.2
Bone: trabecular spacing3.54.67.3-2.51.4-2.1-2.3-2.3-2.0-2.7-2.32.0-2.2-2.22.31.0
Bone: trabecular thickness1.82.14.10.9-1.81.31.41.51.01.31.5-2.01.41.4-1.6-1.5
Bone: trabecular tissue density0.30.40.70.70.80.80.60.60.70.40.60.40.70.5-0.50.8
Water consumed over 24 hours0.91.11.71.0-0.71.31.11.11.21.31.1-1.01.10.8-1.20.1
Number of responses in last shaping day0.60.61.7-0.8-0.2-1.3-1.3-1.2-0.6-0.7-0.8-0.0-0.6-0.80.5-0.2