Hub : Genes

Nop14

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	intron excision ratio	chr14_80322010_80324091	0.03	0.03	5.0e-03	0.02	0.01	0.02	0.02	1.8e-03	9.4e-03	2.0e-03	3.6e-03
2	PL	intron excision ratio	chr14_80322010_80324116	0.03	0.03	6.3e-03	0.02	0.01	0.02	0.02	2.3e-03	1.1e-02	3.8e-03	4.7e-03
3	Liver	gene expression	Nop14	0.06	0.05	7.5e-05	0.04	0.04	0.04	0.04	2.6e-05	4.9e-05	1.9e-05	5.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.8	1.3	1.9	1.4	-1.4	0.1
Area under the delay curve	0.4	0.4	0.6	-0.6	0.6	-0.8
BMI with tail	2.1	7.2	10.7	-3.3	3.3	0.3
BMI without tail	1.7	5.1	7.3	-2.7	2.7	0.8
Body weight	5.0	21.7	30.2	-5.5	5.5	-2.2
Weight adjusted by age	2.4	3.6	4.8	-2.2	2.2	-1.1
Bone surface	0.4	0.7	2.1	-0.1	0.1	-1.4
Bone volume	0.1	0.1	0.2	0.3	-0.3	-0.5
Breakpoint value in progressive ratio session	0.1	0.1	0.1	0.3	-0.3	0.2
Number of licking bursts	0.9	1.4	1.5	-1.2	1.2	-1.1
Context. condit. distance diff. score	0.3	0.3	0.4	0.5	-0.5	0.6
Locomotion velocity, session 1	1.0	1.1	1.4	1.2	-1.2	0.8
Locomotion distance, session 1	0.3	0.4	0.6	0.8	-0.8	0.2
Locomotion velocity, session 2	4.7	5.5	7.9	2.8	-2.8	0.8
Locomotion distance, session 2	2.4	3.4	5.0	2.2	-2.2	0.3
Locomotion velocity, session 3	0.3	0.4	0.5	0.6	-0.6	-0.7
Locomotion distance, session 3	0.0	0.0	0.0	-0.0	0.0	-0.1
Stereotopy head waving bouts, day 3	2.0	2.4	6.7	0.5	-0.5	2.6
Stereotopy head waving duration, day 3	1.6	1.9	5.4	0.4	-0.4	2.3
Locomotion velocity, session 7	1.2	1.3	3.2	-0.6	0.6	-1.8
Locomotion distance, session 7	0.5	0.6	1.2	0.6	-0.6	-1.1
Stereotopy head waving bouts, day 7	1.6	1.8	2.2	-1.5	1.5	1.0
Stereotopy head waving duration, day 7	2.0	2.4	3.6	-1.9	1.9	0.3
Locomotion velocity, session 8	1.4	1.7	2.5	1.6	-1.6	0.1
Locomotion distance, session 8	1.8	2.6	3.4	1.8	-1.8	0.9
Degree of sensitization distance	1.0	1.0	1.5	1.2	-1.2	-0.4
Degree of sensitization stereotypy	1.7	1.9	2.8	-1.7	1.7	0.1
Conditioned locomotion	0.7	0.8	2.3	-0.1	0.1	-1.5
Cocaine response after cond. corrected	1.2	1.4	1.4	1.2	-1.2	1.2
Cocaine response after cond. not corrected	0.5	0.6	0.7	0.7	-0.7	0.8
Cocaine response before conditioning	0.7	0.8	0.8	-0.9	0.9	-0.9
Saline control response	0.2	0.2	0.3	0.5	-0.5	0.3
Bone: connectivity density	0.6	0.9	1.3	1.1	-1.1	-0.3
Bone: cortical apparent density	0.8	1.1	1.6	-0.9	0.9	1.3
Bone: cortical area	4.2	6.5	8.3	-2.9	2.9	-1.7
Bone: cortical porosity	0.3	0.3	0.5	0.7	-0.7	0.2
Bone: cortical porosity	0.1	0.1	0.2	0.1	-0.1	0.5
Bone: cortical thickness	2.8	4.7	6.7	-2.6	2.6	-0.8
Bone: cortical thickness	0.2	0.2	0.5	-0.3	0.3	-0.7
Bone: cortical tissue density	0.9	1.2	2.1	-0.9	0.9	1.4
Condit. Reinf. active minus inactive responses	1.0	1.1	1.2	1.0	-1.0	1.1
Condit. Reinf. active-inactive response ratio	2.3	2.5	2.8	1.7	-1.7	1.4
Condit. Reinf. active responses	0.4	0.5	0.6	0.6	-0.6	0.8
Condit. Reinf. inactive responses	1.0	1.2	1.4	-1.2	1.2	-0.9
Incentive salience index mean	0.0	0.0	0.1	0.2	-0.2	0.3
Condit. Reinf. lever presses	0.7	1.0	1.0	-1.0	1.0	-1.0
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.5	0.5	-0.6
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.2	-0.2	-0.0
Condit. Reinf. active responses	0.1	0.2	0.2	0.3	-0.3	-0.5
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.5	-0.5	-0.0
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.7	0.7	-0.2
Condit. Reinf. lever reinforcers received	0.1	0.2	0.5	0.1	-0.1	-0.7
Conditioned reinforcement - actives	0.3	0.6	0.7	-0.8	0.8	-0.6
Conditioned reinforcement - inactives	0.5	0.7	0.9	-1.0	1.0	-0.5
Conditioned locomotion	0.9	1.1	1.4	-1.2	1.2	-0.7
Patch foraging indifference point 0 sec	0.1	0.1	0.3	0.0	-0.0	0.6
Patch foraging indifference point AUC	0.3	0.4	0.5	0.6	-0.6	0.7
Delay disc. indifference point, 0s delay	0.8	0.9	1.7	-0.7	0.7	-1.3
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	0.2	-0.2	0.2
Delay disc. indifference point, 2s delay	0.1	0.2	0.4	0.1	-0.1	-0.7
Delay disc. indifference point, 24s delay	0.2	0.2	0.2	-0.4	0.4	-0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.2	0.4	-0.4	-0.5
Delay disc. indifference point, 8s delay	0.6	0.7	0.9	-0.9	0.9	-0.7
Indifference point function ln k	0.1	0.2	0.3	0.5	-0.5	0.2
Indifference point function log k	0.1	0.2	0.3	0.5	-0.5	0.2
Patch foraging total patch changes 0 sec	0.1	0.1	0.4	-0.0	0.0	0.7
Patch foraging total patch changes 12 sec	0.2	0.3	0.4	-0.6	0.6	-0.2
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	0.1	-0.1	0.6
Patch foraging total patch changes 24 sec	0.1	0.2	0.6	-0.2	0.2	0.8
Patch foraging total patch changes 6 sec	0.2	0.2	0.7	-0.2	0.2	0.8
Patch foraging time to switch 0 sec	0.8	1.6	2.0	-1.4	1.4	-0.9
Patch foraging water rate 0 sec	0.1	0.1	0.2	-0.4	0.4	-0.2
Patch foraging water rate 12 sec	0.3	0.6	1.9	0.1	-0.1	1.4
Patch foraging water rate 18 sec	0.5	0.8	2.1	-0.4	0.4	1.4
Patch foraging water rate 24 sec	0.6	0.8	1.1	-0.8	0.8	1.1
Patch foraging water rate 6 sec	0.7	1.0	1.4	-1.2	1.2	0.6
Seeking ratio, delayed vs. immediate footshock	1.8	2.2	2.9	1.7	-1.7	1.0
Distance traveled before self-admin	0.9	1.2	1.8	1.3	-1.3	0.2
Distance traveled after self-admin	0.1	0.1	0.2	0.2	-0.2	-0.5
Extensor digitorum longus weight	2.1	8.1	12.1	-3.5	3.5	-0.1
Bone: elastic displacement	0.7	0.8	0.9	-0.9	0.9	-0.9
Bone: elastic work	2.6	3.5	4.8	-2.2	2.2	-0.9
Bone: endosteal estimation	0.8	1.7	3.1	-1.0	1.0	-1.7
Bone: endosteal perimeter	0.9	1.9	3.3	-1.1	1.1	-1.8
Epididymis fat weight	1.7	5.9	7.6	-2.7	2.7	-1.6
Delta time in closed arm before/after self-admin	0.6	0.5	0.8	0.9	-0.9	0.2
Delta time in open arm before/after self-admin	1.3	1.3	1.7	-1.3	1.3	-0.6
Diff in mean of infusions in LGA sessions	0.7	0.8	1.2	1.1	-1.1	0.4
Delay discount exponential model param	0.2	0.3	0.5	0.4	-0.4	0.7
Extinction: sum of active levers before priming	0.7	0.8	0.9	-1.0	1.0	-0.7
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.1	0.1	-0.1
Bone: final force	3.6	5.7	6.7	-2.6	2.6	-1.9
Bone: final moment	2.7	4.4	5.7	-2.4	2.4	-1.3
Food consumed during 24 hour testing period	0.0	0.1	0.1	0.2	-0.2	0.3
Glucose	0.2	0.3	0.7	0.3	-0.3	-0.8
Heart weight	0.9	1.4	1.7	-1.3	1.3	-0.9
Delay discount hyperbolic model param	0.2	0.3	0.6	0.3	-0.3	0.7
Intermittent access intake day 1-15 change	1.9	3.9	5.3	2.3	-2.3	1.0
Intermittent access intake escalation	1.3	2.6	3.6	1.9	-1.9	0.8
Intermittent access intake escalation 2	2.1	2.4	3.2	1.8	-1.8	0.9
Intermitt. access day 1 inactive lever presses	0.1	0.5	0.6	0.8	-0.8	0.5
Intermitt. access day 15 inactive lever presses	0.3	0.6	0.8	0.9	-0.9	0.5
Intermitt. access escalation Index	0.5	0.7	1.0	1.0	-1.0	0.5
Intermittent access day 1 total infusions	0.6	1.0	1.2	-1.1	1.1	-0.8
Intermittent access day 15 total infusions	0.0	0.0	0.0	0.0	-0.0	-0.1
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.3	-0.3	0.1
Intermittent access total infusions	0.1	0.1	0.2	-0.4	0.4	-0.3
Intermittent access day 1 locomotion	0.5	0.7	0.8	-0.9	0.9	-0.6
Intermittent access day 15 total locomotion	0.2	0.3	0.3	-0.6	0.6	-0.5
Intermittent access total locomotion	0.0	0.0	0.0	-0.1	0.1	-0.2
Intermittent access standard deviation	0.3	0.5	0.7	0.8	-0.8	0.4
Left kidney weight	3.5	16.4	24.2	-4.9	4.9	-0.8
Right kidney weight	2.8	12.7	18.7	-4.3	4.3	-0.9
Cocaine induced anxiety	0.4	0.6	0.7	0.8	-0.8	0.6
Post-drug Anxiety	0.1	0.1	0.2	0.4	-0.4	0.0
Baseline Anxiety	1.6	1.8	2.0	-1.4	1.4	-1.2
Tail length	0.6	2.3	3.2	-1.8	1.8	-0.7
Length with tail	2.7	11.9	15.4	-3.9	3.9	-2.2
Length without tail	2.5	8.0	9.8	-3.1	3.1	-2.1
Times rat made contact with spout	0.9	1.1	1.4	1.2	-1.2	0.7
Lifetime Intake	0.1	0.1	0.2	-0.4	0.4	-0.2
Liver weight, left	0.4	0.7	0.9	-0.9	0.9	-0.7
Liver weight, right	2.6	4.5	6.8	-2.6	2.6	-0.2
Locomotor activity	0.1	0.1	0.3	0.1	-0.1	-0.6
Locomotor testing distance	0.4	0.7	0.9	-0.9	0.9	-0.5
Locomotor testing rearing	0.7	1.5	2.1	-1.5	1.5	-0.5
Locomotion in novel chamber	0.4	0.6	0.7	0.8	-0.8	0.6
Locomotion in novel chamber post-restriction	0.1	0.1	0.1	0.3	-0.3	-0.2
Fecal boli incidents, locomotor time 1	0.3	0.5	0.6	0.8	-0.8	0.6
Change in fecal boli incidents, locomotor task	0.5	0.5	0.6	0.8	-0.8	0.4
Time >=10cm from walls, locomotor time 1	1.6	1.6	2.0	-1.4	1.4	-1.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	0.4	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	0.4	0.1
Rest time, locomotor task time 1	1.0	1.2	1.7	-1.3	1.3	-0.5
Distance moved, locomotor task time 1	0.2	0.3	0.5	0.4	-0.4	0.7
Vertical activity count, locomotor time 1	0.4	1.1	1.5	1.2	-1.2	0.4
Time >=10cm from walls, locomotor time 2	0.6	0.9	1.1	-0.9	0.9	-1.0
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.1	-0.1	0.2
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	0.2	-0.0
Rest time, locomotor task time 2	0.7	0.9	1.2	-1.1	1.1	-0.6
Distance moved, locomotor task time 2	0.4	0.5	0.6	0.8	-0.8	0.5
Vertical activity count, locomotor time 2	0.9	1.3	1.9	1.4	-1.4	0.1
Light reinforcement 1	1.6	4.0	6.0	-2.5	2.5	-0.2
Light reinforcement 2	2.3	3.6	5.3	-2.3	2.3	-0.2
Bone: marrow area	0.8	1.7	3.2	-0.9	0.9	-1.8
Bone: maximum diameter	2.8	5.3	7.7	-2.8	2.8	-0.5
Bone: maximum force	2.5	4.5	5.4	-2.3	2.3	-1.6
Bone: maximum moment	1.9	3.3	4.4	-2.1	2.1	-1.0
Mean time between licks in bursts	0.7	1.6	2.1	1.4	-1.4	0.8
Mean num. licks in bursts	2.2	3.5	4.1	2.0	-2.0	1.5
Cd content in liver	0.2	0.2	0.3	0.4	-0.4	-0.5
Co content in liver	0.6	0.6	1.8	-0.2	0.2	-1.3
Cu content in liver	1.0	1.1	1.7	1.3	-1.3	0.1
Fe content in liver	3.1	3.7	5.2	2.3	-2.3	0.9
K content in liver	0.3	0.3	0.8	0.1	-0.1	-0.9
Mg content in liver	1.0	1.0	1.2	-1.1	1.1	-0.8
Mn content in liver	0.4	0.5	0.7	0.8	-0.8	-0.4
Na content in liver	0.5	0.6	0.8	0.7	-0.7	-0.9
Rb content in liver	0.2	0.3	0.6	-0.3	0.3	-0.8
Se content in liver	0.6	0.7	2.1	-0.0	0.0	1.4
Sr content in liver	1.6	1.4	2.0	-1.4	1.4	-0.0
Zn content in liver	0.9	1.0	2.4	-0.5	0.5	1.5
Bone: minimum diameter	1.0	1.8	2.7	-1.1	1.1	-1.7
Time in familiar zone, hab. session 1	0.9	0.9	1.3	0.8	-0.8	1.2
Time in novel zone, hab. session 1	0.4	0.4	0.6	-0.8	0.8	-0.1
Total zone transitions, hab. session 1	0.1	0.2	0.2	0.5	-0.5	-0.2
Total locomotion distance, hab. session 1	0.6	0.8	1.1	1.1	-1.1	-0.3
Locomotion velocity, hab. session 1	0.6	0.9	1.3	0.8	-0.8	-1.1
Time in familiar zone, hab. session 2	2.8	2.9	3.5	1.9	-1.9	1.3
Time in novel zone, hab. session 2	4.8	4.9	7.2	-2.7	2.7	-0.6
Total zone transitions, hab. session 2	0.2	0.2	0.5	-0.2	0.2	0.7
Total locomotion distance, hab. session 2	0.2	0.3	0.8	-0.1	0.1	0.9
Locomotion velocity, hab. session 2	0.1	0.2	0.5	-0.0	0.0	0.7
Novel to familiar place preference ratio	0.2	0.2	0.2	0.4	-0.4	-0.5
Novelty place preference	0.1	0.1	0.2	0.2	-0.2	-0.4
Time in novel zone, NPP test	0.0	0.0	0.1	0.1	-0.1	-0.3
Total zone transitions, NPP test	0.0	0.0	0.1	0.2	-0.2	-0.2
Total locomotion distance, NPP test	0.2	0.3	0.5	0.7	-0.7	0.2
Locomotion velocity, NPP test	0.4	0.6	0.9	1.0	-1.0	0.1
Intraocular pressure	0.4	0.5	0.7	-0.8	0.8	0.5
Delta distance traveled before/after self-admin	0.7	0.7	0.8	-0.9	0.9	-0.7
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	0.1	-0.1	-0.1
Parametrial fat weight	0.1	0.3	0.3	0.5	-0.5	0.6
Pavlov. Cond. lever latency	0.9	1.2	1.5	1.0	-1.0	1.2
Pavlov. Cond. magazine entry latency	0.5	0.7	0.8	0.8	-0.8	0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	0.1	-0.1	-0.6
Pavlov. Cond. index score	0.1	0.1	0.2	0.2	-0.2	-0.4
Pavlov. Cond. latency score	0.1	0.1	0.3	0.0	-0.0	-0.6
Pavlov. Cond. lever contacts	0.7	0.8	1.4	-0.7	0.7	-1.2
Pavlov. Cond. magazine entry number	0.8	1.0	1.3	-1.1	1.1	-0.6
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.6	-0.8	0.8	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.1	-0.1	-0.4
Pavlov. Cond. response bias	0.1	0.1	0.2	0.4	-0.4	0.0
Pavlov. Cond. lever latency	0.4	0.5	0.8	-0.9	0.9	-0.1
Pavlov. Cond. magazine entry latency	1.0	1.2	1.8	-1.3	1.3	-0.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.1	0.1	0.1
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	0.1	0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.1	0.1	0.0
Pavlov. Cond. lever contacts	0.7	1.0	1.4	1.2	-1.2	0.2
Pavlov. Cond. magazine entry number	1.4	1.7	2.5	1.6	-1.6	0.5
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.5	1.2	-1.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.2	0.2	0.1
Pavlov. Cond. response bias	0.0	0.0	0.1	0.2	-0.2	-0.1
Time in closed arm before self-admin	0.1	0.1	0.1	-0.3	0.3	0.2
Time in closed arm after self-admin	0.3	0.4	0.5	0.7	-0.7	0.4
Time in open arm before self-admin	0.1	0.2	0.2	-0.4	0.4	-0.4
Time in open arm after self-admin	1.4	1.5	2.0	-1.4	1.4	-0.8
Bone: periosteal estimation	2.6	5.4	5.5	-2.4	2.4	-2.3
Bone: periosteal perimeter	3.1	5.4	5.5	-2.3	2.3	-2.4
Bone: post-yield work	0.5	0.7	1.1	0.7	-0.7	1.1
Progressive ratio test 1 active lever presses	0.7	0.9	1.1	-1.1	1.1	-0.6
Progressive ratio test 1 breakpoint	0.7	0.9	1.1	-1.0	1.0	-0.7
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.3	-0.5	0.5	-0.2
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.2	0.2	-0.2
Progressive ratio test 2 breakpoint	0.0	0.1	0.1	-0.2	0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.3	0.5	0.6	-0.8	0.8	-0.5
Incentive Sensitization - Responses	0.0	0.0	0.1	0.2	-0.2	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.2	-0.2	0.0
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	-0.1	-0.1
Progressive ratio	0.1	0.1	0.1	-0.2	0.2	-0.4
Food seeking constrained by brief footshock	1.4	1.7	2.2	-1.2	1.2	-1.5
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	-0.1	0.1	-0.4
Retroperitoneal fat weight	0.4	1.7	2.1	-1.4	1.4	-1.0
Reaction time number correct	0.5	1.0	1.1	-1.0	1.0	1.0
Reaction time mean minus median	0.5	1.2	1.7	1.3	-1.3	0.5
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.3	0.3	0.1
Reaction time num false alarms	0.9	1.3	1.6	-1.2	1.2	-0.9
Reaction time num false alarms AUC	1.3	2.1	2.8	-1.7	1.7	-0.7
Reaction time trials correct on left	0.5	1.0	1.1	-1.0	1.0	1.0
Reaction time trials on left	0.5	1.0	1.1	-1.0	1.0	1.0
Reaction time mean	0.8	1.3	2.0	1.4	-1.4	0.1
Reaction time mean AUC	0.7	1.2	1.8	1.3	-1.3	0.2
Median of all reaction times	0.8	1.1	1.7	1.3	-1.3	-0.1
Reaction time omissions	0.5	0.7	1.4	0.6	-0.6	1.2
Reaction time false alarm rate	0.8	1.1	1.1	-1.1	1.1	-1.0
Reaction time premature initiation rate	0.1	0.1	0.2	-0.4	0.4	0.4
Reaction time premature initiations	0.5	0.8	1.0	-0.9	0.9	1.0
Std. dev. reaction times	0.4	0.7	0.9	0.9	-0.9	0.6
Reaction time trials completed	0.5	1.0	1.1	-1.0	1.0	1.0
Reaction time trials AUC	0.5	0.9	1.0	-0.9	0.9	1.0
Run reversals in cocaine runway, females	0.9	0.9	1.4	1.2	-1.2	-0.1
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.5	0.5	-0.3
Latency to leave start box in cocaine runway	0.8	0.9	1.3	-1.1	1.1	-0.5
Latency to leave start box in cocaine runway, F	2.3	2.6	3.3	-1.8	1.8	-1.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.2	-0.2	0.5
Std. dev. time between licks in bursts	0.4	0.5	0.5	0.7	-0.7	-0.7
Total sessions with >9 infusions	0.1	0.1	0.1	-0.4	0.4	-0.3
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.2	0.2	0.0
Short access day 10 total inactive lever presses	0.4	1.1	1.2	1.1	-1.1	0.9
Short access day 1 total infusions	0.0	0.1	0.1	-0.2	0.2	-0.3
Short access day 10 total infusions	0.0	0.0	0.0	-0.1	0.1	0.0
Short access total infusions	0.0	0.0	0.0	-0.0	0.0	-0.0
Short access day 1 locomotion	0.3	0.4	0.5	-0.7	0.7	-0.4
Short access day 10 total locomotion	1.1	2.0	2.6	1.6	-1.6	0.9
Short access total locomotion	0.4	0.5	0.6	0.8	-0.8	0.5
One hour access (0.3 mA shock)	0.0	0.0	0.0	-0.2	0.2	0.0
Compulsive drug intake	0.1	0.1	0.2	0.4	-0.4	0.1
One hour access (shock baseline)	0.0	0.0	0.0	-0.2	0.2	-0.0
Social response proportion	1.1	1.3	1.5	1.1	-1.1	1.2
Social responses	0.3	0.4	1.0	-0.2	0.2	1.0
Social time	0.7	1.0	1.4	1.2	-1.2	0.4
Soleus weight	2.1	6.3	9.1	-3.0	3.0	0.8
Bone: stiffness	1.3	2.1	4.8	-0.9	0.9	-2.2
Tibialis anterior weight	1.1	3.9	5.8	-2.4	2.4	-0.2
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.5	0.7	-0.7	0.3
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.5	0.6	-0.6	0.7
Time to tail flick, test, before self-admin	0.0	0.1	0.1	-0.3	0.3	0.1
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.6	0.6	-0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.4	0.4	0.1
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.1	0.1	0.3
Tibia length	1.0	2.9	4.2	-1.5	1.5	-2.1
Ambulatory time before self-admin	0.5	0.8	1.2	1.1	-1.1	0.0
Ambulatory time after self-admin	0.7	0.8	1.2	1.1	-1.1	-0.1
Bone: tissue strength	0.9	0.9	1.4	-1.2	1.2	0.2
Total heroin consumption	0.2	0.3	0.4	-0.6	0.6	-0.2
Bone: trabecular number	0.3	0.5	0.7	0.7	-0.7	0.8
Bone: trabecular spacing	1.1	1.4	1.5	-1.2	1.2	-1.1
Bone: trabecular thickness	0.7	0.9	1.3	1.1	-1.1	0.3
Bone: trabecular tissue density	0.3	0.5	0.5	0.7	-0.7	-0.6
Water consumed over 24 hours	1.0	1.3	1.8	1.3	-1.3	0.7
Number of responses in last shaping day	0.1	0.1	0.2	0.0	-0.0	-0.4