Hub : Genes

Nol11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Nol11	0.1	0.05	1.9e-05	0.05	0.07	0.06	0.06	3.0e-05	6.8e-07	2.3e-06	7.8e-06
2	PL	gene expression	Nol11	0.03	0.02	4.3e-03	0.02	0.02	0.02	0.02	1.0e-03	6.5e-03	1.7e-03	2.3e-03
3	Brain	mRNA stability	Nol11	0.09	0.05	5.8e-05	0.01	0.04	0.04	0.02	6.0e-02	1.5e-04	1.2e-04	5.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.2	0.3	-0.3	-0.5	0.5
Area under the delay curve	0.4	0.6	1.1	-1.1	0.4	0.8
BMI with tail	2.0	6.8	14.1	-2.5	0.2	3.8
BMI without tail	1.7	9.0	15.4	-3.4	-0.7	3.9
Body weight	1.6	7.1	9.6	-2.9	-1.8	3.1
Weight adjusted by age	0.1	0.2	0.5	-0.4	0.7	-0.1
Bone surface	1.2	2.4	5.9	-0.2	-2.4	-1.1
Bone volume	0.7	1.3	3.5	-0.7	-1.9	-0.2
Breakpoint value in progressive ratio session	0.1	0.2	0.4	0.2	0.2	-0.6
Number of licking bursts	0.0	0.1	0.2	0.0	-0.1	-0.4
Context. condit. distance diff. score	0.1	0.1	0.2	-0.4	0.2	-0.1
Locomotion velocity, session 1	0.2	0.2	0.3	-0.6	-0.3	0.4
Locomotion distance, session 1	1.1	1.4	2.4	-1.6	0.6	1.2
Locomotion velocity, session 2	0.8	0.9	2.3	0.0	-0.7	-1.5
Locomotion distance, session 2	0.4	0.5	1.0	-1.0	0.7	-0.0
Locomotion velocity, session 3	1.7	2.0	2.5	-1.5	1.6	1.1
Locomotion distance, session 3	0.2	0.2	0.4	-0.6	0.3	-0.5
Stereotopy head waving bouts, day 3	0.7	0.9	1.5	-0.3	1.0	1.2
Stereotopy head waving duration, day 3	0.8	1.0	1.4	-0.7	1.1	1.2
Locomotion velocity, session 7	0.1	0.1	0.3	0.5	0.4	0.2
Locomotion distance, session 7	0.1	0.1	0.2	-0.2	0.2	-0.5
Stereotopy head waving bouts, day 7	0.6	0.6	1.7	-0.4	1.3	0.3
Stereotopy head waving duration, day 7	0.6	0.8	2.2	0.2	1.5	-0.3
Locomotion velocity, session 8	0.8	1.0	1.2	0.8	-1.1	-1.1
Locomotion distance, session 8	0.1	0.2	0.4	-0.6	0.1	-0.3
Degree of sensitization distance	0.1	0.2	0.3	0.4	-0.6	-0.1
Degree of sensitization stereotypy	0.8	0.9	2.4	-0.6	1.6	-0.0
Conditioned locomotion	0.1	0.1	0.3	0.1	-0.5	-0.2
Cocaine response after cond. corrected	0.3	0.4	0.7	0.7	0.3	-0.8
Cocaine response after cond. not corrected	0.7	1.0	2.1	0.9	0.3	-1.5
Cocaine response before conditioning	0.1	0.2	0.2	-0.4	0.4	-0.4
Saline control response	0.2	0.3	0.3	-0.5	-0.6	0.6
Bone: connectivity density	0.2	0.4	1.1	-0.1	-1.1	-0.2
Bone: cortical apparent density	3.8	6.1	9.0	-1.3	2.7	3.0
Bone: cortical area	2.4	3.9	6.8	-2.6	0.5	2.2
Bone: cortical porosity	1.6	1.8	2.9	-0.0	-1.6	-1.7
Bone: cortical porosity	0.7	0.8	1.1	-1.0	-0.9	-0.6
Bone: cortical thickness	11.9	19.9	25.0	-3.5	4.8	5.0
Bone: cortical thickness	4.9	6.0	8.1	-1.9	2.8	2.5
Bone: cortical tissue density	3.5	5.6	8.4	-1.2	2.6	2.9
Condit. Reinf. active minus inactive responses	1.0	1.1	2.2	-1.5	-0.8	-0.7
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.0	-0.5	-0.7	-1.0
Condit. Reinf. active responses	1.0	1.3	2.4	-1.5	-1.1	-0.6
Condit. Reinf. inactive responses	0.4	0.5	1.0	-1.0	-0.7	0.2
Incentive salience index mean	0.6	0.8	1.0	-1.0	-0.9	-0.7
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.2	-0.2	-0.5
Condit. Reinf. active minus inactive responses	1.3	2.0	4.5	-2.1	-1.1	-0.6
Condit. Reinf. active-inactive response ratio	0.7	1.1	2.0	-0.5	-1.1	-1.4
Condit. Reinf. active responses	1.7	2.5	4.7	-2.2	-1.6	-0.2
Condit. Reinf. inactive responses	1.5	2.2	4.8	-2.2	-0.7	1.2
Condit. Reinf. lever presses	0.8	1.2	3.3	-1.8	-0.6	-0.0
Condit. Reinf. lever reinforcers received	1.5	2.1	3.7	-1.9	-1.6	-0.2
Conditioned reinforcement - actives	0.2	0.6	1.1	-1.0	-0.0	0.9
Conditioned reinforcement - inactives	0.1	0.3	0.4	-0.5	-0.6	0.4
Conditioned locomotion	0.6	0.9	1.6	-0.8	-1.3	0.5
Patch foraging indifference point 0 sec	1.1	3.1	6.5	-2.6	-1.0	1.3
Patch foraging indifference point AUC	0.3	0.7	1.8	-0.5	-1.3	0.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.3	0.5	0.0
Delay disc. indifference point, 16s delay	0.9	1.2	1.8	-1.3	0.3	1.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	-0.6	-0.5	0.0
Delay disc. indifference point, 24s delay	1.3	2.1	3.2	-1.7	-0.3	1.8
Delay disc. indifference point, 4s delay	0.2	0.2	0.7	-0.2	0.8	-0.1
Delay disc. indifference point, 8s delay	0.4	0.6	0.8	-0.7	0.7	0.9
Indifference point function ln k	0.8	2.3	3.6	-1.4	1.9	1.2
Indifference point function log k	0.8	2.3	3.6	-1.4	1.9	1.2
Patch foraging total patch changes 0 sec	0.9	2.8	5.7	-2.4	-1.1	1.2
Patch foraging total patch changes 12 sec	1.8	2.4	6.4	-0.8	-2.5	-0.4
Patch foraging total patch changes 18 sec	0.4	1.1	1.6	-1.3	-1.2	0.3
Patch foraging total patch changes 24 sec	0.8	2.7	5.0	-2.2	-1.2	1.2
Patch foraging total patch changes 6 sec	1.1	1.8	3.4	-1.8	-1.2	0.8
Patch foraging time to switch 0 sec	0.3	1.0	2.1	1.4	0.1	-0.9
Patch foraging water rate 0 sec	0.4	1.5	2.6	-1.6	-0.8	1.1
Patch foraging water rate 12 sec	0.9	3.6	4.3	-1.5	2.1	2.0
Patch foraging water rate 18 sec	1.1	2.5	2.8	-1.7	1.7	1.4
Patch foraging water rate 24 sec	0.3	0.4	0.8	-0.7	0.9	-0.1
Patch foraging water rate 6 sec	1.3	1.9	2.6	-1.3	1.2	1.6
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.5	-0.6	0.3	0.7
Distance traveled before self-admin	0.1	0.3	0.7	-0.1	0.8	-0.4
Distance traveled after self-admin	0.2	0.3	0.8	-0.3	0.0	-0.9
Extensor digitorum longus weight	0.6	2.3	3.1	1.8	0.8	1.8
Bone: elastic displacement	1.8	2.3	4.2	-0.9	2.0	1.4
Bone: elastic work	1.3	1.7	3.6	-1.0	0.8	1.9
Bone: endosteal estimation	7.2	17.7	35.7	0.9	-6.0	-4.1
Bone: endosteal perimeter	5.8	14.1	32.2	0.2	-5.7	-3.2
Epididymis fat weight	0.1	0.4	0.8	-0.2	-0.7	0.9
Delta time in closed arm before/after self-admin	0.6	0.6	0.9	1.0	-0.4	-0.8
Delta time in open arm before/after self-admin	0.2	0.2	0.4	-0.5	0.3	0.6
Diff in mean of infusions in LGA sessions	0.7	1.3	3.1	0.2	1.8	0.8
Delay discount exponential model param	0.3	0.5	0.9	1.0	-0.2	-0.6
Extinction: sum of active levers before priming	0.2	0.3	0.6	-0.5	0.4	0.8
Active lever presses in extinction session 6	0.3	0.3	0.7	-0.5	-0.8	0.1
Bone: final force	0.7	1.2	2.5	-1.6	0.0	1.0
Bone: final moment	0.7	1.2	2.5	-1.6	0.1	1.0
Food consumed during 24 hour testing period	0.5	0.9	1.4	-0.3	-1.2	1.2
Glucose	0.5	0.8	2.2	-0.1	1.5	0.3
Heart weight	1.2	2.0	2.1	-1.4	1.4	1.4
Delay discount hyperbolic model param	0.2	0.3	0.6	0.8	-0.1	-0.5
Intermittent access intake day 1-15 change	0.2	1.3	2.5	1.6	-0.9	-0.7
Intermittent access intake escalation	0.2	1.0	1.4	1.2	-1.1	-0.6
Intermittent access intake escalation 2	1.6	2.6	3.6	1.9	-1.8	-1.0
Intermitt. access day 1 inactive lever presses	0.1	0.7	1.9	-0.1	-1.4	-0.2
Intermitt. access day 15 inactive lever presses	0.1	0.6	1.0	0.8	-1.0	-0.1
Intermitt. access escalation Index	0.4	1.1	3.3	0.3	1.8	-0.1
Intermittent access day 1 total infusions	0.8	2.3	5.5	-2.3	0.7	1.0
Intermittent access day 15 total infusions	0.2	0.6	1.2	-1.1	-0.3	0.7
Intermittent access terminal intake (last 3 days)	0.3	0.6	1.4	-0.5	-1.2	0.1
Intermittent access total infusions	1.1	1.3	3.4	-1.8	-0.3	0.7
Intermittent access day 1 locomotion	1.4	2.5	6.2	-2.5	-0.0	1.2
Intermittent access day 15 total locomotion	0.5	1.8	2.7	-1.7	-1.4	0.8
Intermittent access total locomotion	3.1	3.7	8.3	-2.9	-1.0	1.3
Intermittent access standard deviation	0.1	0.3	0.8	0.1	-0.9	-0.1
Left kidney weight	0.4	3.6	4.6	-2.1	1.8	1.7
Right kidney weight	0.4	2.9	3.7	-1.9	1.5	1.7
Cocaine induced anxiety	0.2	0.5	0.8	-0.7	0.9	0.3
Post-drug Anxiety	0.3	0.4	0.7	-0.5	0.8	0.3
Baseline Anxiety	0.1	0.2	0.5	0.2	0.3	0.7
Tail length	0.6	3.0	7.0	-1.4	-2.6	0.4
Length with tail	0.7	3.1	8.9	-0.6	-3.0	-0.2
Length without tail	0.1	0.7	1.5	0.7	-1.2	-0.1
Times rat made contact with spout	0.3	0.3	0.7	0.4	-0.8	-0.1
Lifetime Intake	1.8	2.2	5.3	-2.3	-0.2	1.1
Liver weight, left	1.0	1.7	3.5	-0.3	-1.9	-1.3
Liver weight, right	1.6	2.8	3.5	-1.5	1.9	1.7
Locomotor activity	2.1	3.2	7.5	-2.7	0.8	1.3
Locomotor testing distance	1.1	2.8	7.0	-2.6	0.4	1.1
Locomotor testing rearing	0.1	0.3	0.4	-0.4	-0.6	-0.5
Locomotion in novel chamber	0.4	0.5	1.2	0.3	0.4	-1.1
Locomotion in novel chamber post-restriction	0.4	1.1	2.1	0.1	-1.5	-1.1
Fecal boli incidents, locomotor time 1	0.2	0.5	0.7	0.8	-0.3	-0.8
Change in fecal boli incidents, locomotor task	0.4	0.4	1.1	-0.1	-0.1	1.1
Time >=10cm from walls, locomotor time 1	0.6	0.8	1.3	0.5	1.1	-0.9
Bouts of movement, locomotor time 1	0.3	0.4	0.9	0.2	0.5	1.0
Total resting periods, locomotor time 1	0.3	0.3	0.8	0.5	0.2	0.9
Rest time, locomotor task time 1	0.6	1.0	2.5	1.6	-0.6	-0.4
Distance moved, locomotor task time 1	0.1	0.2	0.4	-0.5	0.0	0.7
Vertical activity count, locomotor time 1	0.0	0.1	0.2	-0.4	0.3	0.4
Time >=10cm from walls, locomotor time 2	0.5	1.4	3.0	1.7	-0.1	-1.1
Bouts of movement, locomotor time 2	0.2	0.7	1.6	0.2	0.7	1.3
Total resting periods, locomotor time 2	0.2	0.7	1.3	-0.1	0.9	1.1
Rest time, locomotor task time 2	0.5	0.9	1.6	1.0	1.3	-0.2
Distance moved, locomotor task time 2	0.3	0.4	0.7	0.9	-0.7	-0.1
Vertical activity count, locomotor time 2	0.1	0.3	1.0	0.2	-1.0	0.3
Light reinforcement 1	1.2	5.2	8.6	-2.4	1.2	2.9
Light reinforcement 2	1.1	2.4	4.4	-1.7	0.4	2.1
Bone: marrow area	7.2	17.6	35.0	1.0	-5.9	-4.1
Bone: maximum diameter	1.1	2.2	4.5	-1.4	-2.1	-0.5
Bone: maximum force	1.6	3.2	6.7	-2.6	-0.0	1.7
Bone: maximum moment	1.5	2.9	6.0	-2.5	-0.1	1.7
Mean time between licks in bursts	0.0	0.2	0.2	0.2	-0.4	0.5
Mean num. licks in bursts	0.1	0.2	0.5	0.0	-0.3	0.7
Cd content in liver	2.3	2.6	6.2	2.5	-0.1	-1.2
Co content in liver	0.2	0.3	0.7	0.8	0.4	0.0
Cu content in liver	0.3	0.3	0.6	0.6	-0.8	-0.3
Fe content in liver	0.4	0.5	0.9	-0.7	-0.0	-1.0
K content in liver	0.1	0.1	0.2	-0.3	-0.4	-0.4
Mg content in liver	0.1	0.2	0.4	0.6	-0.1	-0.2
Mn content in liver	0.4	0.4	1.0	-1.0	0.5	0.1
Na content in liver	0.2	0.2	0.3	-0.6	-0.0	-0.5
Rb content in liver	0.6	0.7	1.9	-0.0	1.4	-0.4
Se content in liver	2.1	2.4	3.2	-1.8	1.7	1.1
Sr content in liver	0.3	0.3	0.5	0.2	-0.6	0.7
Zn content in liver	0.1	0.1	0.4	-0.1	0.6	0.1
Bone: minimum diameter	3.1	6.0	15.9	-0.9	-4.0	-1.1
Time in familiar zone, hab. session 1	1.2	1.3	2.0	0.9	-1.4	-1.0
Time in novel zone, hab. session 1	1.5	1.7	2.6	-0.7	1.6	1.5
Total zone transitions, hab. session 1	1.0	1.4	2.3	-1.5	0.6	1.2
Total locomotion distance, hab. session 1	1.6	2.3	4.0	-2.0	0.4	1.6
Locomotion velocity, hab. session 1	1.0	1.4	2.8	-1.7	-0.1	1.1
Time in familiar zone, hab. session 2	1.5	1.7	2.5	0.7	-1.4	-1.6
Time in novel zone, hab. session 2	1.2	1.3	2.0	-0.6	1.2	1.4
Total zone transitions, hab. session 2	0.3	0.4	0.7	-0.7	0.4	0.9
Total locomotion distance, hab. session 2	0.9	1.2	2.3	-1.1	0.1	1.5
Locomotion velocity, hab. session 2	0.8	1.1	2.3	-1.0	0.1	1.5
Novel to familiar place preference ratio	0.3	0.5	0.5	-0.7	-0.5	0.7
Novelty place preference	0.3	0.3	0.5	-0.6	-0.3	0.7
Time in novel zone, NPP test	0.2	0.3	0.5	-0.7	-0.2	0.6
Total zone transitions, NPP test	2.0	3.0	4.9	-2.2	1.3	1.6
Total locomotion distance, NPP test	0.5	0.7	1.6	-1.3	0.0	0.8
Locomotion velocity, NPP test	1.3	1.9	3.1	-1.7	0.4	1.6
Intraocular pressure	1.0	1.6	2.7	-1.6	0.2	1.5
Delta distance traveled before/after self-admin	0.4	0.4	0.9	-0.9	0.4	0.5
Delta ambulatory time before/after self-admin	0.1	0.2	0.5	-0.7	-0.1	0.5
Parametrial fat weight	0.8	1.8	3.3	1.8	-1.1	-1.0
Pavlov. Cond. lever latency	0.6	0.7	1.9	1.4	-0.2	-0.5
Pavlov. Cond. magazine entry latency	0.7	0.9	1.7	-1.3	-1.0	-0.2
Pavlov. Cond. change in total contacts	0.5	0.5	1.2	-1.1	-0.6	-0.0
Pavlov. Cond. index score	0.6	0.8	2.1	-1.4	-0.6	0.1
Pavlov. Cond. latency score	0.6	0.8	2.1	-1.5	-0.4	0.3
Pavlov. Cond. lever contacts	0.1	0.2	0.3	-0.5	-0.4	-0.2
Pavlov. Cond. magazine entry number	0.6	0.8	1.7	1.3	0.7	0.3
Pavlov. Cond. intertrial magazine entries	1.5	1.8	4.8	-2.2	-0.2	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	2.2	-1.5	-0.6	0.1
Pavlov. Cond. response bias	0.7	0.9	1.9	-1.4	-0.8	-0.3
Pavlov. Cond. lever latency	0.3	0.4	1.0	1.0	0.2	0.4
Pavlov. Cond. magazine entry latency	0.5	0.8	1.2	0.5	1.1	-0.9
Pavlov. Cond. change in total contacts	0.3	0.8	1.8	-0.2	-0.7	-1.3
Pavlov. Cond. index score	0.3	0.4	1.0	-0.4	0.2	-1.0
Pavlov. Cond. latency score	0.3	0.5	1.3	-0.4	0.4	-1.1
Pavlov. Cond. lever contacts	0.3	0.5	1.3	-1.2	0.1	-0.1
Pavlov. Cond. magazine entry number	0.9	1.2	2.7	-0.3	-1.6	1.0
Pavlov. Cond. intertrial magazine entries	2.1	4.7	13.6	0.3	-3.7	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.2	-0.3	0.2	-1.1
Pavlov. Cond. response bias	0.2	0.3	0.7	-0.8	0.2	-0.4
Time in closed arm before self-admin	0.5	0.8	1.3	-1.2	0.7	0.8
Time in closed arm after self-admin	0.3	0.4	0.8	0.9	-0.1	-0.6
Time in open arm before self-admin	0.3	0.4	0.6	0.7	0.8	-0.2
Time in open arm after self-admin	0.0	0.0	0.0	-0.1	-0.0	0.0
Bone: periosteal estimation	2.1	5.0	12.5	-1.1	-3.5	-1.1
Bone: periosteal perimeter	0.9	1.8	3.6	-1.3	-1.9	-0.5
Bone: post-yield work	0.6	1.0	1.9	-0.2	-1.4	-1.0
Progressive ratio test 1 active lever presses	1.4	2.5	5.4	-2.3	0.1	1.4
Progressive ratio test 1 breakpoint	1.4	2.4	5.2	-2.3	-0.0	1.4
Progressive ratio test 1 inactive lever presses	0.7	1.9	4.1	-2.0	-0.3	1.2
Progressive ratio test 2 active lever presses	1.0	1.4	2.9	-1.7	-1.0	0.3
Progressive ratio test 2 breakpoint	1.0	1.3	2.6	-1.6	-1.2	0.2
Progressive ratio test 2 inactive lever presses	0.8	2.4	4.6	-2.2	-0.1	1.6
Incentive Sensitization - Responses	0.3	0.8	1.8	-0.4	-1.3	-0.6
Incentive Sensitization - Breakpoint	0.4	0.9	2.0	-0.3	-1.4	-0.7
Sum of active levers in priming session hrs 5-6	1.1	1.0	2.4	-0.7	1.6	0.4
Progressive ratio	0.2	0.5	1.2	0.5	-0.4	-1.1
Food seeking constrained by brief footshock	4.2	5.2	8.2	1.8	-2.9	-2.0
Seeking ratio, punishment vs. effort	0.3	0.7	2.1	-0.0	-1.4	-0.2
Retroperitoneal fat weight	0.2	0.8	1.7	0.2	-1.3	0.8
Reaction time number correct	0.3	1.1	1.6	-1.1	1.3	0.6
Reaction time mean minus median	0.1	0.7	1.7	1.3	-0.0	-0.5
Reaction time mean minus median AUC	0.1	0.5	1.4	-0.0	1.2	0.3
Reaction time num false alarms	0.9	1.5	2.9	-1.7	-1.2	-0.2
Reaction time num false alarms AUC	0.6	1.4	2.2	-1.4	-1.5	-0.3
Reaction time trials correct on left	0.3	1.1	1.6	-1.1	1.3	0.6
Reaction time trials on left	0.3	1.1	1.5	-1.1	1.2	0.6
Reaction time mean	0.4	0.8	1.5	0.6	0.8	-1.2
Reaction time mean AUC	0.4	1.0	1.5	0.8	0.9	-1.2
Median of all reaction times	0.5	0.8	1.4	0.3	1.0	-1.2
Reaction time omissions	0.2	0.3	0.5	0.6	-0.7	-0.1
Reaction time false alarm rate	1.0	1.4	3.5	-0.4	-1.9	-0.8
Reaction time premature initiation rate	0.8	1.3	2.0	-1.4	-0.2	1.4
Reaction time premature initiations	0.6	1.8	2.7	-1.6	0.3	1.6
Std. dev. reaction times	0.5	1.5	2.9	1.7	-0.2	-1.3
Reaction time trials completed	0.3	1.1	1.5	-1.1	1.2	0.6
Reaction time trials AUC	0.3	0.9	1.5	-1.0	1.2	0.6
Run reversals in cocaine runway, females	0.7	0.8	1.6	1.3	0.4	0.8
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.1	0.1	-0.3
Latency to leave start box in cocaine runway	0.1	0.2	0.6	-0.1	0.7	0.0
Latency to leave start box in cocaine runway, F	0.6	0.8	1.3	-1.0	1.1	0.1
Latency to leave start box in cocaine runway, M	0.6	0.6	1.6	1.3	-0.1	-0.5
Std. dev. time between licks in bursts	0.0	0.1	0.1	0.3	-0.1	0.3
Total sessions with >9 infusions	3.6	4.4	6.9	-2.6	1.4	2.1
Short access day 1 total inactive lever presses	0.9	1.8	3.8	-2.0	-0.1	1.3
Short access day 10 total inactive lever presses	0.0	0.2	0.6	-0.2	-0.1	0.8
Short access day 1 total infusions	3.6	7.1	13.3	-3.7	1.7	2.2
Short access day 10 total infusions	1.5	2.5	4.7	-2.2	-0.1	1.7
Short access total infusions	2.2	3.1	6.8	-2.6	0.6	1.5
Short access day 1 locomotion	5.0	8.3	14.2	-3.8	0.9	3.1
Short access day 10 total locomotion	0.4	1.7	2.3	-1.4	-1.5	0.9
Short access total locomotion	2.7	4.1	7.4	-2.7	-0.0	2.2
One hour access (0.3 mA shock)	0.2	0.2	0.4	-0.4	-0.7	-0.4
Compulsive drug intake	0.4	0.5	0.8	0.7	0.6	-0.9
One hour access (shock baseline)	0.2	0.5	0.8	-0.7	-0.9	0.4
Social response proportion	0.1	0.1	0.2	-0.3	0.4	0.3
Social responses	0.5	0.6	1.1	-1.1	0.5	0.6
Social time	0.9	1.4	2.4	1.2	-0.3	-1.6
Soleus weight	0.5	1.4	2.7	-1.6	0.8	1.0
Bone: stiffness	0.5	0.9	2.4	-1.6	-0.2	0.4
Tibialis anterior weight	0.5	1.6	4.5	0.2	-0.4	2.1
Time to tail flick, vehicle, before self-admin	1.5	1.9	4.1	1.2	-0.4	-2.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.5	0.2	0.1
Time to tail flick, test, before self-admin	0.6	0.7	1.0	1.0	-0.4	-1.0
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.2	-0.2	0.1
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.3	0.2	-1.2	0.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.5	-0.1	-0.2
Tibia length	1.1	3.1	5.5	-2.3	1.5	1.2
Ambulatory time before self-admin	0.1	0.2	0.3	0.0	0.5	-0.5
Ambulatory time after self-admin	0.1	0.2	0.5	-0.7	0.1	-0.1
Bone: tissue strength	1.6	1.7	2.7	-1.4	1.6	0.7
Total heroin consumption	0.4	0.5	0.9	-0.7	0.1	-0.9
Bone: trabecular number	0.2	0.4	0.6	-0.6	-0.8	0.1
Bone: trabecular spacing	0.3	0.4	0.7	0.8	-0.1	-0.7
Bone: trabecular thickness	0.5	0.6	1.0	-0.6	-0.8	1.0
Bone: trabecular tissue density	2.4	4.2	4.9	-1.9	2.0	2.2
Water consumed over 24 hours	0.3	0.5	1.3	-0.3	0.2	1.1
Number of responses in last shaping day	0.6	0.7	1.2	-1.1	0.5	0.9