Hub : Genes

Noc3l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr1_245974748_245975079 0.04 0.03 3.9e-04 0.03 0.02 0.02 0.02 5.1e-04 1.3e-03 3.1e-03 3.7e-03
2 IC gene expression Noc3l 0.13 0.07 1.7e-05 0.07 0.07 0.03 0.07 5.3e-04 6.7e-04 2.8e-02 9.3e-04
3 RMTg gene expression Noc3l 0.13 0.1 9.0e-03 0.05 0.05 0.05 0.04 1.8e-02 1.6e-02 2.2e-02 2.4e-02
4 RMTg intron excision ratio chr1_245974620_245975079 0.13 0.1 6.7e-03 0.02 0.01 0.02 0.01 9.3e-02 1.4e-01 8.5e-02 1.4e-01
5 RMTg intron excision ratio chr1_245974748_245975079 0.13 0.1 7.3e-03 0.02 0.01 0.02 0.01 1.1e-01 1.7e-01 7.8e-02 1.5e-01
6 Adipose gene expression Noc3l 0.21 0.08 0.0e+00 0.19 0.21 0.2 0.2 6.0e-21 5.2e-23 2.9e-22 9.7e-22
7 Liver gene expression Noc3l 0.1 0.06 7.9e-10 0.07 0.06 0.06 0.07 1.7e-08 1.4e-07 1.5e-07 4.1e-08
8 Adipose mRNA stability Noc3l 0.15 0.07 0.0e+00 0.13 0.14 0.14 0.13 2.5e-14 7.8e-15 8.4e-15 2.0e-14
9 Liver mRNA stability Noc3l 0.03 0.02 1.0e-03 0.02 0.02 0.02 0.01 5.2e-03 3.1e-03 6.2e-03 1.1e-02
10 NAcc gene expression Noc3l 0.22 0.08 0.0e+00 0.24 0.27 0.28 0.28 9.5e-37 1.8e-41 8.0e-42 8.2e-43
11 BLA gene expression Noc3l 0.24 0.1 1.0e-12 0.19 0.21 0.2 0.2 3.2e-10 2.2e-11 8.4e-11 5.8e-11
12 pVTA gene expression Noc3l 0.26 0.1 7.8e-15 0.11 0.19 0.2 0.18 2.4e-09 2.2e-15 1.1e-15 2.4e-14
13 OFC gene expression Noc3l 0.35 0.15 4.1e-06 0.1 0.22 0.22 0.22 2.4e-03 5.0e-06 7.9e-06 7.7e-06
14 PL gene expression Noc3l 0.17 0.07 0.0e+00 0.11 0.19 0.19 0.19 2.4e-12 1.9e-20 1.0e-20 1.9e-20
15 LHb gene expression Noc3l 0.59 0.18 3.3e-04 0.05 0.11 0.14 0.07 2.4e-02 1.6e-03 2.6e-04 7.6e-03
16 PL mRNA stability Noc3l 0.04 0.03 6.0e-04 0.04 0.02 0.02 0.03 4.4e-05 1.3e-03 1.2e-03 3.5e-04
17 Brain gene expression Noc3l 0.29 0.11 0.0e+00 0.24 0.33 0.33 0.34 1.4e-22 3.3e-31 7.1e-32 3.1e-32
18 NAcc isoform ratio NM_001108523.1 0.04 0.02 2.3e-05 0.02 0.03 0.02 0.02 2.6e-04 7.6e-05 8.8e-04 1.1e-04
19 Brain mRNA stability Noc3l 0.08 0.04 8.3e-07 0.06 0.06 0.05 0.07 1.1e-06 3.9e-06 9.8e-06 8.6e-07
20 pVTA mRNA stability Noc3l 0.04 0.03 5.2e-03 0.01 0.01 -0 0.01 4.7e-02 2.5e-02 3.7e-01 3.6e-02
21 pVTA isoform ratio NM_001108523.1 0.12 0.1 9.7e-03 0.01 0.02 0.04 0.01 7.1e-02 5.2e-03 1.4e-04 7.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density2.03.65.52.41.9-2.2-2.32.3-2.12.1-2.3-2.4-2.2-2.21.9-1.91.61.31.4-1.6-1.5-1.4-0.91.0
Area under the delay curve0.30.41.6-0.6-0.81.00.6-0.71.1-0.70.40.30.40.0-0.40.00.0-0.70.8-0.5-0.6-0.8-1.30.5
BMI with tail0.62.03.81.81.8-1.6-1.31.3-1.81.9-1.5-1.6-1.7-1.61.0-1.51.30.11.2-1.5-0.9-1.1-0.30.8
BMI without tail0.00.10.50.60.4-0.30.1-0.1-0.50.7-0.1-0.1-0.3-0.1-0.1-0.2-0.1-0.4-0.3-0.20.20.00.40.6
Body weight0.10.31.21.10.7-0.7-0.60.6-0.80.6-0.2-0.2-0.40.00.2-0.00.00.4-0.50.30.60.71.10.3
Weight adjusted by age0.10.32.3-0.10.5-0.1-0.30.3-0.40.9-0.1-0.3-0.2-0.3-0.6-0.00.0-1.50.1-0.50.1-0.20.1-1.1
Bone surface2.24.37.22.72.5-2.5-2.62.6-2.42.5-2.5-2.4-2.4-2.22.1-2.01.71.51.3-1.7-1.3-1.2-0.51.0
Bone volume1.53.05.52.42.1-2.3-2.32.3-2.22.2-2.1-2.0-1.9-1.71.7-1.41.31.10.9-1.1-0.7-0.7-0.00.5
Breakpoint value in progressive ratio session0.20.42.4-0.2-0.50.40.3-0.40.6-0.90.10.10.0-0.10.5-0.40.20.90.5-0.2-0.8-0.6-0.91.5
Number of licking bursts0.30.82.5-1.6-0.91.41.0-0.91.4-1.00.80.60.80.3-1.00.3-0.4-1.10.90.2-0.5-0.5-1.20.2
Context. condit. distance diff. score1.11.32.71.11.6-1.2-1.41.4-1.00.6-1.2-1.2-1.1-1.01.3-0.91.41.21.4-1.1-0.7-1.0-0.50.3
Locomotion velocity, session 11.31.54.2-1.8-1.81.91.5-1.52.1-1.61.21.01.30.7-1.00.7-0.5-0.90.20.2-0.4-0.5-1.40.2
Locomotion distance, session 10.60.82.1-1.4-1.51.31.1-1.01.4-1.30.90.80.90.6-0.90.6-0.7-0.5-0.40.5-0.10.0-0.80.1
Locomotion velocity, session 22.73.28.11.00.5-0.7-1.00.9-0.2-0.1-1.5-1.5-1.7-1.92.0-2.11.62.42.1-1.9-2.7-2.4-2.82.6
Locomotion distance, session 20.50.72.60.3-0.30.0-0.20.20.2-0.4-0.5-0.5-0.6-0.80.7-1.00.61.20.9-0.6-1.4-1.1-1.61.6
Locomotion velocity, session 30.20.21.20.50.1-0.4-0.20.2-0.2-0.2-0.4-0.4-0.5-0.40.6-0.50.31.1-0.1-0.2-0.5-0.3-0.40.5
Locomotion distance, session 30.30.31.10.3-0.2-0.2-0.00.00.0-0.70.20.40.30.70.10.6-0.31.0-1.00.90.80.90.9-0.0
Stereotopy head waving bouts, day 30.00.00.20.0-0.50.2-0.10.10.3-0.3-0.0-0.1-0.1-0.1-0.40.0-0.1-0.3-0.2-0.0-0.2-0.3-0.5-0.1
Stereotopy head waving duration, day 30.20.31.30.1-0.10.0-0.60.60.2-0.1-0.4-0.5-0.4-0.60.0-0.50.4-0.00.6-0.7-0.9-1.0-1.1-0.1
Locomotion velocity, session 71.11.24.31.41.1-1.5-2.02.1-1.20.5-1.2-1.1-1.1-0.81.1-0.61.01.50.2-0.5-0.2-0.20.1-0.8
Locomotion distance, session 71.01.33.51.61.4-1.6-1.91.9-1.50.9-1.2-1.1-1.1-0.71.2-0.70.81.50.1-0.5-0.1-0.10.5-0.4
Stereotopy head waving bouts, day 70.50.62.2-0.7-1.01.00.4-0.41.4-1.50.50.40.50.2-0.40.20.10.00.80.1-0.7-0.5-1.31.2
Stereotopy head waving duration, day 70.20.31.2-0.6-0.80.80.2-0.11.1-1.10.50.40.60.4-0.50.50.1-0.20.60.1-0.1-0.2-0.70.1
Locomotion velocity, session 80.50.61.50.60.4-0.5-0.40.4-0.2-0.2-0.7-0.7-0.8-0.80.9-0.90.91.21.0-0.9-1.0-1.0-1.11.1
Locomotion distance, session 82.03.04.91.41.6-1.2-1.51.4-0.90.4-1.7-1.7-1.7-1.81.9-2.02.02.02.2-1.9-2.1-2.1-1.91.8
Degree of sensitization distance0.91.01.90.70.8-0.6-1.11.1-0.60.8-1.0-1.0-1.0-1.20.9-1.11.00.51.3-1.4-1.2-1.4-1.10.3
Degree of sensitization stereotypy0.80.83.1-1.1-1.11.30.7-0.71.6-1.80.70.70.80.4-0.40.3-0.20.20.70.5-0.5-0.2-1.11.6
Conditioned locomotion0.60.72.90.40.4-0.4-0.10.2-0.61.00.20.20.40.6-0.50.9-0.4-1.0-0.90.61.41.11.6-1.7
Cocaine response after cond. corrected0.10.10.40.1-0.20.0-0.20.20.0-0.3-0.1-0.1-0.3-0.30.0-0.5-0.20.70.1-0.2-0.5-0.5-0.60.5
Cocaine response after cond. not corrected0.20.31.50.1-0.30.0-0.20.20.1-0.7-0.2-0.2-0.5-0.40.3-0.70.01.20.3-0.3-0.9-0.7-0.91.1
Cocaine response before conditioning0.30.31.3-0.5-0.50.40.4-0.40.7-1.10.20.10.1-0.00.2-0.20.40.80.6-0.2-0.6-0.6-0.91.0
Saline control response1.72.34.7-1.8-2.02.02.2-2.22.0-2.01.71.51.51.3-1.41.1-1.2-1.2-0.81.30.40.6-0.31.2
Bone: connectivity density3.35.39.23.02.5-2.7-2.82.8-2.73.0-2.8-2.8-2.7-2.62.2-2.31.91.21.3-2.0-1.6-1.6-0.80.7
Bone: cortical apparent density0.30.51.4-1.2-1.11.10.8-0.81.1-0.70.60.50.70.3-0.70.4-0.2-1.00.30.0-0.2-0.3-0.80.7
Bone: cortical area0.20.41.60.80.5-0.7-0.70.7-0.70.3-0.2-0.0-0.10.30.20.3-0.10.6-0.80.50.90.81.3-0.7
Bone: cortical porosity2.73.05.01.41.2-1.2-1.71.7-1.00.9-1.8-1.9-1.9-2.11.7-2.11.71.62.2-1.7-2.2-2.0-2.20.9
Bone: cortical porosity2.42.63.91.51.3-1.3-1.61.6-1.10.8-1.7-1.7-1.8-1.81.8-1.91.61.92.0-1.5-1.9-1.7-1.80.7
Bone: cortical thickness1.72.84.1-1.8-1.91.71.6-1.61.8-2.02.02.01.92.0-1.61.9-1.7-0.7-1.51.71.51.51.0-1.0
Bone: cortical thickness1.92.45.4-2.1-2.02.11.8-1.82.2-2.31.81.71.71.5-1.61.3-1.4-1.0-0.51.20.50.6-0.30.0
Bone: cortical tissue density0.30.51.2-1.1-1.01.00.7-0.71.1-0.50.50.40.60.2-0.60.3-0.1-1.00.5-0.2-0.4-0.5-0.90.7
Condit. Reinf. active minus inactive responses0.10.10.2-0.5-0.50.40.3-0.30.5-0.40.20.30.30.30.10.3-0.30.4-0.10.2-0.0-0.0-0.20.2
Condit. Reinf. active-inactive response ratio0.10.10.2-0.4-0.20.30.4-0.40.3-0.00.30.30.40.40.00.4-0.20.0-0.10.20.30.10.20.0
Condit. Reinf. active responses0.10.20.4-0.5-0.60.40.3-0.30.4-0.30.30.40.50.5-0.10.5-0.50.3-0.50.50.30.30.1-0.1
Condit. Reinf. inactive responses0.10.10.3-0.3-0.60.30.1-0.10.3-0.30.20.20.20.2-0.30.2-0.50.0-0.50.40.00.2-0.1-0.1
Incentive salience index mean0.30.40.9-0.9-0.80.81.0-1.00.8-0.60.80.80.70.7-0.30.6-0.70.1-0.50.50.30.30.10.0
Condit. Reinf. lever presses0.91.42.8-1.7-1.21.51.7-1.71.3-0.91.51.51.41.3-1.01.1-1.1-0.8-0.70.80.80.60.4-0.7
Condit. Reinf. active minus inactive responses1.11.73.71.81.8-1.8-1.61.6-1.91.8-1.5-1.5-1.4-1.21.1-0.91.20.20.5-0.8-0.1-0.20.5-0.5
Condit. Reinf. active-inactive response ratio0.81.32.61.51.6-1.5-1.31.3-1.61.6-1.3-1.4-1.3-1.20.9-0.91.1-0.10.7-1.0-0.3-0.50.1-0.5
Condit. Reinf. active responses0.30.52.20.60.6-0.7-0.10.1-0.80.6-0.1-0.1-0.00.3-0.20.5-0.2-0.5-0.80.81.11.21.5-1.0
Condit. Reinf. inactive responses1.92.85.0-1.4-1.51.31.7-1.71.2-1.51.81.81.82.0-1.61.9-1.9-0.7-1.92.21.92.21.6-0.7
Condit. Reinf. lever presses0.40.51.5-0.6-0.80.71.2-1.20.8-1.10.80.70.60.6-0.70.6-0.8-0.5-0.70.80.40.60.20.3
Condit. Reinf. lever reinforcers received0.20.31.30.30.3-0.30.2-0.2-0.40.20.10.10.10.4-0.40.5-0.3-0.6-0.70.80.91.11.1-0.6
Conditioned reinforcement - actives0.20.93.10.2-0.1-0.1-0.0-0.00.2-0.3-0.5-0.5-0.7-0.71.1-1.01.01.81.2-1.0-1.4-1.4-1.41.6
Conditioned reinforcement - inactives0.82.28.00.60.2-0.5-1.21.10.0-0.4-1.2-1.1-1.2-1.31.6-1.51.42.82.0-1.1-2.1-1.9-2.42.0
Conditioned locomotion0.10.20.6-0.7-0.80.50.3-0.30.7-0.50.40.40.30.4-0.50.3-0.30.3-0.10.10.0-0.1-0.2-0.2
Patch foraging indifference point 0 sec0.51.52.8-1.1-1.11.21.7-1.71.1-1.21.41.41.31.4-1.01.2-1.3-0.7-1.61.21.11.10.9-0.8
Patch foraging indifference point AUC1.53.68.0-2.6-2.62.72.3-2.42.8-2.72.22.12.21.7-1.71.4-1.4-0.9-0.51.20.30.4-0.70.9
Delay disc. indifference point, 0s delay1.31.42.61.31.2-1.1-0.90.9-1.01.1-1.4-1.5-1.3-1.51.0-1.31.40.11.3-1.6-1.3-1.5-1.10.4
Delay disc. indifference point, 16s delay0.30.42.3-0.4-0.70.80.8-0.80.9-0.60.40.30.30.0-0.2-0.2-0.2-0.20.6-0.1-0.6-0.5-1.11.5
Delay disc. indifference point, 2s delay0.20.21.70.10.00.1-0.10.00.00.4-0.2-0.4-0.1-0.4-0.5-0.20.3-1.30.6-0.8-0.4-0.7-0.6-0.8
Delay disc. indifference point, 24s delay0.61.03.4-1.2-1.51.51.0-1.11.8-1.81.01.01.00.7-0.50.5-0.4-0.00.50.0-0.4-0.4-1.10.8
Delay disc. indifference point, 4s delay0.40.42.0-0.3-0.30.50.5-0.50.6-0.50.0-0.2-0.1-0.50.1-0.50.3-0.20.9-0.8-1.1-1.1-1.41.0
Delay disc. indifference point, 8s delay1.11.94.8-1.8-1.92.11.4-1.42.2-1.81.51.41.61.2-1.41.3-0.9-1.60.20.50.3-0.1-0.8-0.5
Indifference point function ln k1.13.47.52.72.5-2.7-2.32.4-2.72.4-2.2-2.1-2.1-1.71.7-1.41.21.30.3-0.9-0.3-0.20.6-0.5
Indifference point function log k1.13.47.52.72.5-2.7-2.32.4-2.72.4-2.2-2.1-2.1-1.71.7-1.41.21.30.3-0.9-0.3-0.20.6-0.5
Patch foraging total patch changes 0 sec0.61.83.0-1.1-1.21.21.7-1.71.1-1.21.51.51.41.5-1.11.4-1.4-0.8-1.71.31.31.31.1-0.9
Patch foraging total patch changes 12 sec3.74.99.6-3.1-2.73.02.9-2.93.0-2.62.62.52.52.1-2.21.9-2.1-1.8-1.11.60.80.9-0.1-0.0
Patch foraging total patch changes 18 sec0.51.32.7-1.4-1.51.61.4-1.51.6-1.31.31.21.31.0-1.10.9-0.8-1.2-0.40.50.30.1-0.30.2
Patch foraging total patch changes 24 sec0.41.42.6-1.2-1.61.41.4-1.51.4-1.41.41.51.41.4-0.71.3-1.0-0.3-1.00.80.90.70.5-0.4
Patch foraging total patch changes 6 sec3.25.410.6-3.0-2.93.03.2-3.33.2-3.22.82.72.72.4-1.82.0-1.8-1.0-1.31.60.90.9-0.1-0.1
Patch foraging time to switch 0 sec0.10.31.1-1.0-0.50.80.6-0.70.7-0.30.40.30.30.0-0.5-0.0-0.1-0.80.6-0.7-0.4-0.8-0.80.1
Patch foraging water rate 0 sec0.20.71.61.31.0-1.2-1.11.1-1.10.9-0.9-0.8-0.8-0.50.9-0.40.51.0-0.10.20.00.40.6-0.3
Patch foraging water rate 12 sec0.10.20.70.50.3-0.7-0.60.6-0.60.2-0.4-0.3-0.3-0.00.60.00.00.9-0.40.60.30.50.6-0.3
Patch foraging water rate 18 sec0.40.93.21.40.7-1.2-1.31.3-0.90.2-1.1-0.9-1.0-0.71.2-0.80.71.80.4-0.0-0.5-0.1-0.10.2
Patch foraging water rate 24 sec0.40.61.21.10.9-1.0-1.11.1-0.90.7-0.9-0.8-0.9-0.60.8-0.60.50.90.3-0.2-0.3-0.10.0-0.4
Patch foraging water rate 6 sec0.10.10.30.50.1-0.4-0.50.5-0.30.2-0.3-0.3-0.4-0.20.1-0.20.10.40.10.3-0.10.20.00.3
Seeking ratio, delayed vs. immediate footshock0.20.30.6-0.4-0.30.50.4-0.50.5-0.40.70.80.80.8-0.50.7-0.4-0.4-0.60.50.80.70.7-0.3
Distance traveled before self-admin0.51.12.01.10.7-0.9-0.90.8-0.70.4-1.1-1.1-1.1-1.11.1-1.21.21.11.0-0.9-1.2-1.0-1.01.4
Distance traveled after self-admin1.22.13.41.61.3-1.5-1.71.6-1.41.1-1.7-1.8-1.7-1.81.1-1.71.10.91.0-1.0-1.5-1.1-1.11.4
Extensor digitorum longus weight0.10.41.31.00.7-0.9-1.01.0-0.91.1-0.7-0.7-0.5-0.40.5-0.20.40.30.0-0.20.20.10.4-0.2
Bone: elastic displacement0.30.43.7-0.5-0.00.1-0.10.1-0.11.10.1-0.10.30.0-0.70.5-0.3-1.9-0.4-0.20.50.00.4-1.6
Bone: elastic work0.30.41.20.40.7-0.6-0.70.7-0.61.1-0.7-0.8-0.6-0.80.2-0.50.3-0.70.4-0.7-0.4-0.5-0.3-0.5
Bone: endosteal estimation3.48.314.73.83.6-3.6-3.63.6-3.53.4-3.4-3.3-3.3-2.93.1-2.72.52.41.4-2.0-1.6-1.4-0.41.3
Bone: endosteal perimeter3.38.115.03.83.9-3.6-3.33.3-3.53.4-3.3-3.2-3.2-2.93.0-2.72.62.01.7-2.4-1.6-1.6-0.41.0
Epididymis fat weight0.31.34.81.61.4-1.6-1.21.3-1.92.2-0.9-0.9-0.8-0.40.00.10.2-1.2-0.80.21.00.91.7-0.8
Delta time in closed arm before/after self-admin1.00.91.7-0.9-0.70.70.6-0.50.6-0.71.01.11.11.2-0.91.2-1.2-0.4-1.11.21.21.31.1-0.9
Delta time in open arm before/after self-admin3.54.17.01.81.8-1.6-1.31.2-1.51.0-2.0-2.1-2.3-2.42.0-2.62.31.62.3-2.6-2.5-2.6-2.02.0
Diff in mean of infusions in LGA sessions0.61.21.71.11.0-1.3-1.21.2-1.20.9-1.3-1.2-1.2-1.11.2-1.11.31.20.8-1.1-0.8-0.9-0.4-0.1
Delay discount exponential model param0.30.51.80.60.8-1.0-0.60.7-1.10.8-0.4-0.3-0.4-0.00.30.0-0.10.5-0.90.50.70.91.3-0.6
Extinction: sum of active levers before priming0.00.10.3-0.0-0.20.00.1-0.10.0-0.20.20.30.10.30.50.10.20.6-0.20.10.30.30.40.1
Active lever presses in extinction session 67.27.210.22.32.3-2.2-2.62.5-2.01.5-2.9-2.9-2.9-3.12.8-3.13.02.33.2-3.1-3.1-3.2-2.71.9
Bone: final force0.10.22.00.60.3-0.4-0.40.4-0.2-0.2-0.3-0.2-0.5-0.20.5-0.50.01.40.20.3-0.30.2-0.10.8
Bone: final moment0.10.11.10.50.4-0.4-0.40.4-0.3-0.1-0.2-0.1-0.3-0.00.3-0.2-0.11.1-0.10.30.10.30.30.2
Food consumed during 24 hour testing period0.20.41.4-0.7-0.90.80.4-0.40.9-1.20.70.80.60.8-0.30.6-0.60.6-0.20.70.30.3-0.10.3
Glucose0.10.10.60.1-0.1-0.40.2-0.1-0.30.3-0.10.1-0.10.20.50.1-0.20.7-0.80.30.40.40.60.2
Heart weight1.52.47.0-0.9-0.60.50.5-0.50.20.21.31.51.51.8-1.32.0-1.5-1.2-2.51.72.52.22.6-1.7
Delay discount hyperbolic model param0.30.41.30.60.7-0.8-0.60.6-0.90.6-0.4-0.2-0.4-0.00.4-0.0-0.10.7-0.80.50.60.81.1-0.2
Intermittent access intake day 1-15 change0.52.54.62.11.9-1.8-1.51.5-1.71.4-1.8-1.7-1.9-1.61.8-1.71.91.81.4-1.4-1.2-1.3-0.50.7
Intermittent access intake escalation0.63.35.72.42.1-2.1-1.81.7-2.01.8-2.0-1.9-2.1-1.82.1-1.92.11.81.6-1.7-1.3-1.4-0.50.7
Intermittent access intake escalation 23.05.17.32.52.3-2.4-2.12.0-2.21.8-2.5-2.4-2.6-2.42.7-2.42.72.32.2-2.4-1.9-2.2-1.21.1
Intermitt. access day 1 inactive lever presses0.00.20.50.50.5-0.5-0.40.4-0.50.3-0.6-0.7-0.5-0.70.2-0.60.30.00.5-0.2-0.6-0.4-0.60.2
Intermitt. access day 15 inactive lever presses0.00.20.80.20.4-0.5-0.60.7-0.50.7-0.4-0.4-0.1-0.10.10.10.10.2-0.2-0.10.30.10.3-0.9
Intermitt. access escalation Index0.10.31.4-0.20.3-0.4-0.50.6-0.40.7-0.10.00.40.3-0.30.5-0.3-0.3-0.70.50.80.81.0-1.2
Intermittent access day 1 total infusions0.10.41.00.30.1-0.3-0.70.7-0.2-0.0-0.6-0.6-0.6-0.70.4-0.70.71.00.6-0.6-0.9-0.8-1.00.4
Intermittent access day 15 total infusions0.71.84.41.61.5-1.7-1.51.5-1.51.3-1.5-1.3-1.5-1.21.5-1.31.52.10.8-1.1-0.8-0.8-0.10.2
Intermittent access terminal intake (last 3 days)1.11.84.91.41.2-1.4-1.51.5-1.20.8-1.5-1.4-1.5-1.31.4-1.41.72.21.2-1.3-1.2-1.3-0.80.4
Intermittent access total infusions0.40.51.70.70.6-0.8-0.90.9-0.60.5-0.8-0.7-0.7-0.70.6-0.70.91.30.5-0.7-0.6-0.7-0.4-0.2
Intermittent access day 1 locomotion0.30.50.90.60.8-0.8-0.80.8-0.90.8-0.7-0.7-0.8-0.70.4-0.80.50.90.2-0.6-0.5-0.5-0.20.5
Intermittent access day 15 total locomotion0.10.41.6-0.2-0.20.2-0.20.10.4-0.6-0.2-0.2-0.5-0.40.2-0.60.51.01.0-0.8-1.0-1.1-1.30.5
Intermittent access total locomotion1.01.22.60.60.5-0.5-0.90.9-0.30.3-1.0-1.0-1.1-1.20.6-1.31.01.41.3-1.2-1.5-1.6-1.61.1
Intermittent access standard deviation0.73.89.71.91.8-1.8-1.61.5-1.50.8-2.0-1.8-2.1-1.82.8-2.12.33.12.1-2.1-1.8-2.1-1.30.9
Left kidney weight0.10.71.4-0.9-0.90.80.4-0.40.9-1.21.01.11.01.2-0.51.0-0.80.4-1.01.00.80.90.7-0.0
Right kidney weight0.43.04.7-1.8-1.71.71.6-1.61.7-1.92.02.22.02.1-1.51.9-2.0-0.4-1.92.01.71.81.3-0.5
Cocaine induced anxiety0.51.32.41.61.3-1.4-1.41.5-1.41.2-1.4-1.4-1.2-1.20.8-1.01.20.50.7-1.2-0.6-0.8-0.20.3
Post-drug Anxiety0.70.82.80.40.3-0.30.1-0.0-0.61.10.20.20.40.6-1.20.9-0.7-1.4-1.30.91.51.31.7-0.8
Baseline Anxiety1.72.86.5-1.2-0.81.01.3-1.30.7-0.11.61.71.61.8-1.71.9-2.1-1.6-2.12.52.12.62.1-1.1
Tail length0.20.82.2-0.2-0.50.40.6-0.50.4-0.60.91.00.91.2-0.51.2-0.9-0.1-1.41.11.41.31.5-0.5
Length with tail0.21.02.0-0.5-0.90.70.4-0.40.9-1.31.11.21.01.4-0.51.2-0.90.7-1.31.41.11.41.1-0.2
Length without tail0.10.64.60.60.2-0.5-1.21.2-0.1-0.4-0.5-0.4-0.5-0.40.9-0.50.82.10.6-0.0-0.6-0.2-0.50.1
Times rat made contact with spout0.20.30.90.4-0.2-0.2-0.50.5-0.0-0.3-0.5-0.6-0.7-0.60.3-0.50.40.40.4-0.5-0.8-0.7-1.00.3
Lifetime Intake0.20.30.60.60.4-0.6-0.70.7-0.50.5-0.6-0.6-0.5-0.60.3-0.50.70.70.3-0.6-0.5-0.6-0.4-0.4
Liver weight, left0.10.20.4-0.4-0.10.30.3-0.30.30.00.50.60.60.6-0.20.6-0.1-0.2-0.40.40.70.60.7-0.3
Liver weight, right0.20.40.90.90.9-0.9-0.90.9-0.80.5-0.6-0.6-0.7-0.50.8-0.50.70.90.2-0.4-0.2-0.20.20.1
Locomotor activity0.00.00.10.2-0.20.0-0.00.10.1-0.30.0-0.0-0.00.0-0.20.1-0.0-0.00.10.3-0.00.2-0.1-0.2
Locomotor testing distance0.00.00.2-0.1-0.20.20.2-0.30.3-0.50.10.00.10.0-0.10.0-0.0-0.00.30.2-0.20.1-0.30.3
Locomotor testing rearing0.30.91.31.01.1-1.0-0.80.8-0.90.9-1.1-1.1-1.0-1.11.1-1.01.10.71.0-1.1-0.9-0.8-0.50.7
Locomotion in novel chamber3.75.07.62.22.8-2.6-2.62.6-2.72.3-2.6-2.7-2.8-2.62.1-2.52.11.61.7-1.8-1.7-1.5-0.80.7
Locomotion in novel chamber post-restriction0.10.44.10.1-0.20.10.3-0.30.2-0.5-0.1-0.1-0.4-0.40.2-0.7-0.11.10.20.1-0.8-0.3-0.72.0
Fecal boli incidents, locomotor time 10.30.92.20.90.7-0.6-1.41.3-0.40.1-0.9-0.9-0.8-0.90.8-0.81.30.81.5-0.9-0.9-1.1-1.00.6
Change in fecal boli incidents, locomotor task0.50.61.9-0.8-0.60.71.4-1.30.5-0.40.90.90.70.8-0.40.6-0.8-0.5-1.00.40.60.50.70.0
Time >=10cm from walls, locomotor time 10.50.77.5-0.10.10.0-0.10.10.4-1.20.10.3-0.00.31.5-0.20.52.70.5-0.0-0.3-0.1-0.31.3
Bouts of movement, locomotor time 10.30.41.5-0.9-0.80.90.3-0.31.0-1.20.50.40.60.4-0.30.40.0-0.60.5-0.1-0.1-0.4-0.70.2
Total resting periods, locomotor time 10.50.62.7-1.0-1.11.10.4-0.41.3-1.70.50.50.60.3-0.10.30.1-0.10.6-0.0-0.5-0.6-1.20.9
Rest time, locomotor task time 10.30.52.6-0.2-0.20.3-0.20.20.4-0.3-0.3-0.4-0.2-0.60.5-0.50.5-0.11.2-0.3-1.1-0.9-1.41.6
Distance moved, locomotor task time 10.41.14.0-0.4-0.30.10.9-0.9-0.10.10.80.90.61.0-0.50.8-1.40.2-2.01.21.41.61.8-1.3
Vertical activity count, locomotor time 10.10.51.40.1-0.20.10.6-0.5-0.0-0.30.60.70.30.8-0.30.5-0.80.7-1.20.90.91.11.2-0.4
Time >=10cm from walls, locomotor time 20.10.32.5-0.2-0.10.1-0.20.20.4-0.7-0.10.10.00.01.1-0.20.41.60.6-0.2-0.5-0.4-0.60.7
Bouts of movement, locomotor time 20.41.43.5-1.8-1.31.71.3-1.41.9-1.80.90.70.90.3-0.60.1-0.1-0.71.2-0.4-0.9-1.1-1.81.3
Total resting periods, locomotor time 20.41.63.8-1.8-1.31.71.3-1.41.9-2.00.90.70.90.2-0.40.00.0-0.51.4-0.5-1.1-1.2-2.01.6
Rest time, locomotor task time 20.40.73.5-0.6-0.60.70.6-0.61.0-1.20.10.10.1-0.30.8-0.40.30.21.3-0.5-1.1-1.0-1.51.9
Distance moved, locomotor task time 20.60.73.00.20.1-0.7-0.50.6-0.80.9-0.00.1-0.00.40.00.5-0.60.5-1.70.91.11.31.6-1.7
Vertical activity count, locomotor time 20.10.20.70.60.1-0.4-0.60.6-0.40.3-0.2-0.1-0.20.10.00.00.20.8-0.40.10.30.30.5-0.6
Light reinforcement 10.10.61.9-0.9-0.80.90.7-0.70.8-0.50.70.60.80.6-1.10.7-0.9-1.4-0.60.80.40.50.20.3
Light reinforcement 20.51.23.0-1.5-1.51.60.9-0.91.7-1.31.00.91.30.7-1.40.9-0.8-1.60.10.50.0-0.2-0.90.6
Bone: marrow area3.58.614.93.93.6-3.7-3.73.7-3.63.4-3.5-3.3-3.3-3.03.2-2.82.52.41.4-2.1-1.7-1.4-0.51.3
Bone: maximum diameter3.06.111.83.43.2-3.3-3.43.4-3.32.9-2.9-2.8-2.7-2.42.5-2.12.11.90.9-1.7-1.0-0.90.20.4
Bone: maximum force0.61.32.31.51.1-1.2-1.21.2-1.10.8-1.3-1.2-1.4-1.21.3-1.30.81.50.9-0.7-1.1-0.7-0.71.0
Bone: maximum moment0.50.91.91.41.1-1.2-1.21.2-1.10.8-1.1-1.1-1.2-1.01.1-1.00.61.20.6-0.6-0.7-0.5-0.30.4
Mean time between licks in bursts0.21.33.2-0.7-0.50.61.2-1.20.4-0.21.11.21.11.4-0.71.4-0.9-1.0-1.30.81.71.21.7-1.8
Mean num. licks in bursts0.61.54.32.11.1-1.8-1.51.5-1.81.2-1.4-1.3-1.5-1.01.4-0.90.91.4-0.4-0.8-0.2-0.20.6-0.1
Cd content in liver1.71.93.6-1.6-1.91.61.3-1.31.6-1.61.51.61.61.6-1.41.6-1.1-1.0-1.01.11.10.80.5-1.0
Co content in liver5.76.711.2-2.2-2.01.82.0-2.01.5-1.32.52.62.93.0-2.83.2-2.7-2.8-2.82.83.33.13.0-2.6
Cu content in liver2.22.66.1-2.3-2.22.42.2-2.22.5-2.21.71.51.51.0-1.50.9-1.1-1.20.20.6-0.3-0.3-1.30.7
Fe content in liver1.21.43.4-1.6-1.91.81.5-1.51.7-1.31.41.31.41.1-1.31.0-0.9-0.8-0.30.80.30.3-0.4-0.1
K content in liver1.81.76.00.40.5-0.1-0.30.30.0-0.4-0.7-0.8-1.0-1.21.1-1.61.51.22.4-1.7-2.0-2.0-2.11.6
Mg content in liver1.11.24.20.10.40.1-0.20.10.2-0.5-0.5-0.5-0.7-0.91.0-1.11.41.02.1-1.7-1.6-1.9-1.81.1
Mn content in liver1.61.87.8-0.9-0.61.10.6-0.61.3-1.30.0-0.1-0.2-0.70.1-1.00.80.32.4-1.3-2.0-2.0-2.82.3
Na content in liver0.50.63.2-0.5-0.80.80.6-0.60.9-0.90.30.20.0-0.2-0.0-0.50.20.50.9-0.5-1.0-0.9-1.41.8
Rb content in liver0.10.10.5-0.10.2-0.1-0.40.40.1-0.2-0.1-0.00.10.10.40.20.50.30.5-0.10.1-0.1-0.0-0.7
Se content in liver9.110.723.9-4.5-4.94.84.2-4.34.9-4.83.63.43.32.5-3.42.0-2.5-1.8-0.11.7-0.10.1-2.01.4
Sr content in liver0.30.21.3-0.5-0.70.50.3-0.30.6-0.80.30.30.20.1-0.2-0.1-0.50.30.20.3-0.40.0-0.51.1
Zn content in liver0.70.82.3-1.3-1.31.41.1-1.11.5-1.51.00.90.80.6-0.80.4-0.5-0.50.30.2-0.3-0.3-0.90.4
Bone: minimum diameter3.46.513.83.63.6-3.7-3.43.4-3.73.4-2.9-2.6-2.7-2.02.8-1.81.92.00.2-1.3-0.3-0.21.30.2
Time in familiar zone, hab. session 10.10.20.60.30.1-0.4-0.50.6-0.50.4-0.3-0.4-0.4-0.4-0.5-0.2-0.1-0.6-0.40.10.00.10.1-0.7
Time in novel zone, hab. session 10.20.21.7-0.4-0.20.50.6-0.60.6-0.60.40.40.40.20.20.1-0.20.30.30.1-0.2-0.1-0.31.3
Total zone transitions, hab. session 10.20.32.0-0.0-0.3-0.00.1-0.10.1-0.3-0.4-0.4-0.5-0.60.5-0.70.20.80.4-0.2-1.0-0.5-1.01.4
Total locomotion distance, hab. session 10.71.03.1-1.2-1.61.41.4-1.41.6-1.81.00.80.80.5-0.90.4-0.7-0.20.10.6-0.4-0.1-1.00.8
Locomotion velocity, hab. session 11.52.15.8-1.8-2.12.01.9-1.92.2-2.41.51.41.31.1-1.40.9-1.4-0.3-0.41.3-0.10.4-0.90.8
Time in familiar zone, hab. session 21.72.04.9-0.9-0.70.80.9-0.90.6-0.21.21.21.51.5-1.71.8-1.3-2.2-1.71.51.91.81.7-1.7
Time in novel zone, hab. session 20.30.31.60.1-0.2-0.1-0.30.30.1-0.4-0.3-0.3-0.5-0.40.6-0.60.31.20.4-0.3-0.9-0.6-0.91.3
Total zone transitions, hab. session 20.40.61.2-1.0-1.10.91.1-1.10.9-0.50.80.80.80.7-0.60.6-0.7-0.4-1.00.70.30.50.10.2
Total locomotion distance, hab. session 21.31.72.5-1.5-1.61.51.5-1.51.5-1.21.51.51.51.4-1.41.4-1.0-1.1-1.11.11.00.80.4-0.7
Locomotion velocity, hab. session 20.91.22.2-1.4-1.41.51.5-1.51.5-1.21.31.31.21.1-1.21.0-0.9-0.9-0.70.90.50.5-0.0-0.4
Novel to familiar place preference ratio6.07.912.42.42.3-2.1-2.52.4-1.81.7-3.0-3.0-3.0-3.23.1-3.23.22.53.5-3.2-3.3-3.4-3.02.1
Novelty place preference6.28.012.12.42.3-2.2-2.52.5-1.91.8-3.0-3.1-3.1-3.33.1-3.33.12.53.5-3.1-3.4-3.3-3.02.2
Time in novel zone, NPP test6.17.410.42.42.2-2.2-2.52.4-1.91.7-2.9-3.0-3.0-3.23.0-3.12.92.43.2-3.0-3.2-3.1-2.92.1
Total zone transitions, NPP test0.71.01.8-1.1-1.41.11.1-1.11.1-1.31.11.11.01.0-0.80.8-1.30.1-1.21.10.50.80.20.2
Total locomotion distance, NPP test1.82.56.0-1.8-2.32.12.0-2.02.3-2.51.81.71.61.5-1.51.3-1.6-0.5-0.81.40.40.6-0.40.1
Locomotion velocity, NPP test1.52.14.9-1.7-2.01.91.9-1.92.1-2.21.71.61.51.4-1.31.1-1.4-0.4-0.71.20.40.5-0.40.3
Intraocular pressure0.30.51.9-1.0-0.30.71.0-0.90.5-0.10.70.60.70.5-0.80.6-0.5-1.4-0.10.10.50.20.2-1.1
Delta distance traveled before/after self-admin1.01.12.41.21.5-1.4-1.31.3-1.51.5-1.3-1.3-1.3-1.20.8-1.10.60.30.3-0.7-0.5-0.40.0-0.1
Delta ambulatory time before/after self-admin0.91.53.41.41.8-1.7-1.61.6-1.81.8-1.5-1.5-1.4-1.31.0-1.00.80.40.3-0.8-0.4-0.40.3-0.5
Parametrial fat weight1.02.33.6-1.3-1.31.41.3-1.41.4-1.41.71.81.71.9-1.51.7-1.6-0.6-1.71.91.61.91.30.2
Pavlov. Cond. lever latency0.20.31.7-0.0-0.20.10.2-0.2-0.00.10.30.30.50.4-0.80.6-0.4-1.3-0.70.50.80.70.8-0.4
Pavlov. Cond. magazine entry latency0.70.82.2-1.1-1.21.00.8-0.81.1-1.51.01.20.91.1-0.40.8-0.90.7-0.71.10.50.80.2-0.1
Pavlov. Cond. change in total contacts0.10.11.2-0.3-0.60.20.1-0.10.3-0.50.20.40.20.40.30.3-0.21.1-0.30.20.20.10.1-0.1
Pavlov. Cond. index score0.30.31.3-0.8-0.80.70.5-0.50.8-1.10.50.60.30.40.10.1-0.31.10.00.4-0.3-0.0-0.60.5
Pavlov. Cond. latency score0.20.31.2-0.7-0.70.50.5-0.40.7-0.90.40.50.20.30.20.0-0.31.10.00.4-0.30.0-0.40.4
Pavlov. Cond. lever contacts0.10.20.8-0.5-0.40.50.4-0.40.6-0.60.30.40.10.20.2-0.1-0.20.90.20.0-0.3-0.3-0.50.2
Pavlov. Cond. magazine entry number0.20.20.60.50.5-0.3-0.20.1-0.30.5-0.4-0.5-0.3-0.50.1-0.40.4-0.70.5-0.7-0.4-0.5-0.30.4
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.3-0.50.40.3-0.30.5-0.50.30.20.30.3-0.20.30.1-0.20.2-0.40.1-0.4-0.3-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.31.1-0.8-0.80.60.5-0.50.8-1.00.50.60.30.40.10.1-0.31.1-0.00.4-0.3-0.0-0.50.5
Pavlov. Cond. response bias0.10.10.9-0.5-0.50.40.3-0.20.4-0.50.30.40.20.40.10.2-0.31.0-0.10.40.00.1-0.10.0
Pavlov. Cond. lever latency1.31.83.71.41.9-1.5-1.61.6-1.61.9-1.5-1.4-1.3-1.41.3-1.21.30.41.3-1.5-0.8-1.1-0.3-0.0
Pavlov. Cond. magazine entry latency0.40.51.8-0.7-1.20.70.5-0.50.9-1.30.70.80.70.9-0.50.8-0.50.7-0.50.70.50.40.0-0.4
Pavlov. Cond. change in total contacts0.30.81.2-0.8-1.00.91.1-1.10.9-1.11.01.00.91.0-0.90.9-0.8-0.2-1.00.90.80.80.5-0.3
Pavlov. Cond. index score0.81.23.5-1.1-1.71.21.3-1.31.4-1.91.21.31.11.2-0.91.0-0.90.3-0.91.20.60.70.10.1
Pavlov. Cond. latency score0.61.03.1-1.0-1.61.11.1-1.01.3-1.81.01.10.91.1-0.70.9-0.80.5-0.71.00.40.6-0.10.1
Pavlov. Cond. lever contacts1.62.34.1-1.5-2.01.61.8-1.81.7-1.91.71.71.61.6-1.51.5-1.6-0.7-1.61.71.11.30.6-0.1
Pavlov. Cond. magazine entry number1.92.55.71.82.2-1.8-1.61.5-2.02.4-1.8-1.8-1.7-1.81.3-1.61.5-0.21.1-1.7-1.0-1.1-0.20.5
Pavlov. Cond. intertrial magazine entries0.61.43.11.51.7-1.4-1.41.4-1.51.8-1.3-1.3-1.2-1.20.8-1.01.2-0.00.8-1.0-0.5-0.6-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.71.13.5-1.1-1.71.21.1-1.11.4-1.91.11.11.01.1-0.70.9-0.80.5-0.81.00.40.6-0.10.2
Pavlov. Cond. response bias1.52.13.9-1.5-2.01.61.7-1.61.7-2.01.61.61.51.6-1.41.5-1.4-0.3-1.31.61.01.20.5-0.4
Time in closed arm before self-admin0.30.51.00.40.6-0.5-0.90.9-0.40.7-0.8-0.9-0.6-0.80.9-0.60.90.11.0-1.0-0.8-1.0-0.80.1
Time in closed arm after self-admin0.60.72.5-0.8-0.60.60.4-0.40.40.10.70.70.90.8-0.81.1-1.1-1.6-1.01.01.01.10.8-0.8
Time in open arm before self-admin0.60.82.7-0.4-0.30.20.3-0.30.00.20.50.50.70.7-1.41.0-0.8-1.4-1.00.91.21.11.1-1.7
Time in open arm after self-admin1.11.22.50.70.8-0.6-0.20.2-0.60.1-0.9-1.0-1.2-1.30.9-1.51.10.81.4-1.4-1.6-1.5-1.31.5
Bone: periosteal estimation1.84.38.52.92.7-2.7-2.82.7-2.72.4-2.4-2.3-2.3-1.92.3-1.81.71.90.8-1.3-0.9-0.70.10.7
Bone: periosteal perimeter1.63.27.02.62.6-2.4-2.32.3-2.52.3-2.0-2.0-1.9-1.61.8-1.41.51.20.6-1.2-0.5-0.50.4-0.1
Bone: post-yield work0.91.62.71.71.3-1.4-1.31.4-1.31.1-1.4-1.3-1.4-1.31.5-1.31.21.21.1-1.4-0.9-1.1-0.50.4
Progressive ratio test 1 active lever presses0.20.41.10.60.1-0.2-0.20.2-0.10.1-0.5-0.5-0.6-0.70.3-0.80.70.80.6-0.8-1.0-1.0-1.00.9
Progressive ratio test 1 breakpoint0.20.30.90.5-0.0-0.00.0-0.10.10.0-0.3-0.4-0.4-0.50.2-0.70.60.70.6-0.7-0.9-0.9-1.00.8
Progressive ratio test 1 inactive lever presses0.30.71.00.60.7-0.7-0.80.8-0.60.5-1.0-1.0-0.9-1.00.8-0.90.81.00.6-0.5-1.0-0.7-0.90.9
Progressive ratio test 2 active lever presses1.31.83.70.90.6-0.8-1.21.2-0.50.3-1.3-1.3-1.3-1.41.4-1.41.81.81.8-1.7-1.7-1.9-1.80.7
Progressive ratio test 2 breakpoint1.31.73.50.80.5-0.8-1.21.2-0.50.2-1.3-1.2-1.2-1.31.3-1.31.71.71.8-1.6-1.6-1.9-1.70.6
Progressive ratio test 2 inactive lever presses0.41.43.00.50.7-0.7-0.80.9-0.40.4-1.2-1.2-1.1-1.40.8-1.31.31.21.6-1.3-1.6-1.7-1.71.0
Incentive Sensitization - Responses0.92.54.90.90.8-1.1-1.81.7-0.60.1-1.6-1.5-1.5-1.51.7-1.52.12.22.1-1.7-1.8-2.0-1.80.9
Incentive Sensitization - Breakpoint0.92.04.70.70.6-0.9-1.61.6-0.5-0.1-1.4-1.3-1.3-1.31.6-1.31.92.21.9-1.5-1.6-1.8-1.70.8
Sum of active levers in priming session hrs 5-60.20.20.6-0.4-0.50.40.4-0.40.4-0.30.50.40.40.5-0.70.5-0.4-0.7-0.40.40.40.40.3-0.8
Progressive ratio0.51.43.0-0.9-0.50.60.5-0.50.30.20.91.01.21.3-1.41.5-1.1-1.5-1.71.21.71.41.6-1.6
Food seeking constrained by brief footshock0.20.31.9-0.4-0.50.40.6-0.60.6-1.40.30.40.30.30.3-0.0-0.11.10.30.3-0.30.1-0.40.6
Seeking ratio, punishment vs. effort0.30.72.30.0-0.40.30.4-0.40.6-1.4-0.1-0.1-0.3-0.40.9-0.80.41.51.2-0.4-1.3-0.8-1.41.5
Retroperitoneal fat weight0.31.63.7-0.9-0.40.60.6-0.60.4-0.01.11.11.21.4-1.31.7-1.3-1.8-1.51.61.91.81.8-0.2
Reaction time number correct1.13.86.32.52.2-2.2-2.52.5-2.22.3-2.2-2.2-2.2-2.12.0-1.92.01.11.4-1.8-1.3-1.3-0.60.4
Reaction time mean minus median0.10.62.4-0.2-0.4-0.1-0.30.4-0.1-0.30.40.60.50.9-0.10.9-0.50.7-1.50.81.21.11.3-1.5
Reaction time mean minus median AUC0.10.84.7-0.1-0.4-0.1-0.30.4-0.1-0.10.40.60.50.9-0.41.0-0.60.2-1.50.81.31.21.4-2.2
Reaction time num false alarms0.20.30.7-0.3-0.30.30.7-0.70.2-0.00.50.60.50.7-0.20.6-0.4-0.3-0.70.40.70.60.80.3
Reaction time num false alarms AUC0.10.30.8-0.3-0.20.20.7-0.70.2-0.00.60.60.50.7-0.10.6-0.5-0.1-0.70.50.80.80.90.3
Reaction time trials correct on left1.13.86.32.52.2-2.2-2.52.5-2.22.3-2.2-2.2-2.2-2.12.0-1.92.01.11.4-1.8-1.3-1.3-0.60.4
Reaction time trials on left1.03.56.02.42.1-2.2-2.42.4-2.22.2-2.2-2.1-2.1-2.01.9-1.81.91.11.3-1.7-1.2-1.2-0.50.3
Reaction time mean1.22.64.2-1.7-1.81.41.3-1.21.4-1.51.81.91.92.0-1.42.0-1.5-0.6-1.91.71.91.71.4-1.4
Reaction time mean AUC1.12.53.8-1.7-1.81.51.4-1.41.4-1.41.81.91.82.0-1.51.9-1.6-0.6-1.91.71.71.71.3-1.3
Median of all reaction times1.62.43.7-1.7-1.81.51.4-1.41.5-1.41.71.81.91.9-1.51.9-1.4-0.9-1.61.61.61.51.1-0.9
Reaction time omissions0.61.05.5-0.0-0.3-0.3-0.80.8-0.2-0.10.30.50.61.0-0.41.1-0.60.3-1.51.11.51.41.6-2.3
Reaction time false alarm rate1.31.73.3-1.4-1.21.31.8-1.81.2-1.11.51.61.51.6-1.01.4-1.3-0.8-1.21.21.31.21.10.1
Reaction time premature initiation rate0.71.11.8-1.2-1.00.91.3-1.31.0-1.31.21.31.01.2-0.41.0-1.20.6-1.01.30.81.10.7-0.1
Reaction time premature initiations0.10.21.40.1-0.0-0.2-0.00.1-0.1-0.20.10.2-0.00.30.50.2-0.31.2-0.60.70.30.60.5-0.2
Std. dev. reaction times0.72.46.1-1.0-1.10.60.6-0.50.5-0.71.31.51.51.9-1.11.9-1.5-0.0-2.51.82.22.12.2-2.4
Reaction time trials completed1.03.56.02.42.1-2.2-2.42.4-2.22.2-2.2-2.1-2.1-2.01.9-1.81.91.11.3-1.7-1.2-1.2-0.50.3
Reaction time trials AUC0.93.35.72.32.0-2.1-2.42.4-2.12.2-2.1-2.1-2.0-1.91.8-1.71.81.01.3-1.6-1.2-1.2-0.50.3
Run reversals in cocaine runway, females0.20.20.9-0.3-0.20.50.4-0.40.5-0.20.1-0.00.2-0.2-0.2-0.20.3-0.70.9-0.6-0.6-0.8-0.90.4
Run reversals in cocaine runway, males2.42.64.7-1.9-2.02.02.1-2.12.1-2.21.91.91.81.7-1.41.3-1.7-0.5-0.71.60.71.00.00.9
Latency to leave start box in cocaine runway1.01.45.20.91.2-1.5-1.31.3-1.81.9-0.9-0.8-0.6-0.30.20.10.2-0.8-1.30.11.10.81.7-2.3
Latency to leave start box in cocaine runway, F1.62.06.51.71.9-2.1-1.61.7-2.32.5-1.6-1.5-1.3-1.11.1-0.80.8-0.2-0.5-0.70.30.11.1-1.2
Latency to leave start box in cocaine runway, M0.60.53.8-0.30.0-0.2-0.20.3-0.40.20.20.20.40.5-0.70.8-0.4-1.0-1.10.51.10.81.2-2.0
Std. dev. time between licks in bursts1.42.64.3-1.6-1.51.72.0-1.91.4-0.91.81.81.91.8-2.01.8-1.3-2.1-0.81.01.61.11.1-1.8
Total sessions with >9 infusions0.10.20.8-0.2-0.30.40.9-0.90.20.10.30.20.20.0-0.60.0-0.4-0.9-0.40.1-0.10.0-0.10.1
Short access day 1 total inactive lever presses1.12.13.61.51.5-1.5-1.81.8-1.51.9-1.8-1.9-1.6-1.90.4-1.51.3-0.21.2-1.5-1.3-1.4-1.00.2
Short access day 10 total inactive lever presses0.00.10.4-0.3-0.60.3-0.00.00.5-0.50.30.30.40.4-0.20.6-0.3-0.1-0.60.50.40.40.1-0.1
Short access day 1 total infusions0.20.30.9-0.6-0.90.80.7-0.70.8-0.60.50.30.50.1-0.90.2-0.2-0.8-0.1-0.1-0.3-0.4-0.7-0.2
Short access day 10 total infusions0.81.32.1-1.3-1.41.31.3-1.31.2-0.91.21.21.31.1-1.41.1-1.2-1.1-1.01.00.80.80.3-1.1
Short access total infusions0.00.10.40.1-0.30.10.1-0.10.1-0.1-0.1-0.2-0.0-0.3-0.2-0.20.3-0.00.1-0.3-0.5-0.5-0.6-0.1
Short access day 1 locomotion0.40.71.80.50.9-0.6-0.10.1-0.81.3-0.8-1.0-0.9-1.20.2-1.10.6-0.80.9-1.0-0.9-1.0-0.70.3
Short access day 10 total locomotion0.10.31.4-0.0-0.30.2-0.30.20.3-0.1-0.2-0.2-0.3-0.5-0.1-0.60.10.70.8-0.4-0.9-0.8-1.20.8
Short access total locomotion0.10.20.5-0.10.00.00.2-0.2-0.10.3-0.2-0.4-0.3-0.6-0.3-0.5-0.0-0.40.3-0.4-0.7-0.6-0.70.7
One hour access (0.3 mA shock)3.74.49.11.71.7-1.9-2.02.0-1.51.1-2.3-2.1-2.2-2.22.6-2.32.33.02.5-2.0-2.2-2.2-1.81.6
Compulsive drug intake0.50.71.80.61.3-1.2-1.11.1-1.21.3-0.9-0.8-0.5-0.41.2-0.20.40.4-0.2-0.40.30.10.7-1.0
One hour access (shock baseline)0.30.72.20.60.4-0.5-0.50.5-0.40.2-0.7-0.6-0.8-0.70.7-1.00.91.51.2-0.7-1.0-1.0-0.91.3
Social response proportion3.54.46.62.22.6-2.2-2.42.3-2.22.3-2.3-2.3-2.3-2.31.9-2.22.41.02.2-2.6-1.7-2.0-1.0-0.2
Social responses0.91.22.61.21.6-1.3-1.01.0-1.31.6-1.1-1.2-1.3-1.21.0-1.21.10.40.8-1.4-0.8-1.0-0.20.2
Social time0.10.21.00.00.5-0.00.6-0.6-0.10.3-0.0-0.1-0.4-0.30.4-0.50.40.30.5-1.0-0.4-0.7-0.20.5
Soleus weight0.82.35.91.91.8-2.0-2.42.4-2.02.0-1.8-1.7-1.6-1.31.3-1.01.30.90.7-1.0-0.3-0.50.2-0.9
Bone: stiffness0.61.13.61.50.9-1.2-1.21.2-1.00.5-1.2-1.0-1.3-1.01.4-1.20.71.90.5-0.3-0.9-0.3-0.41.2
Tibialis anterior weight0.51.73.21.61.2-1.5-1.81.8-1.51.6-1.6-1.5-1.5-1.31.3-1.21.11.10.5-1.2-0.8-0.8-0.30.1
Time to tail flick, vehicle, before self-admin0.30.41.6-0.6-0.20.40.2-0.20.40.1-0.1-0.3-0.0-0.5-0.5-0.50.1-0.90.8-0.4-0.9-0.9-1.11.3
Time to tail flick, vehicle, after self-admin0.30.61.90.71.0-0.8-0.40.4-0.80.9-0.9-0.9-0.8-0.91.4-0.90.50.70.6-0.5-0.7-0.5-0.41.0
Time to tail flick, test, before self-admin1.01.11.80.91.2-1.0-0.90.9-0.90.9-1.1-1.1-1.1-1.11.3-1.11.31.11.1-1.2-1.0-1.2-0.70.8
Time to tail flick, test, after self-admin0.10.11.00.0-0.10.0-0.20.20.00.4-0.2-0.3-0.1-0.3-0.3-0.0-0.1-1.00.0-0.1-0.2-0.3-0.30.3
Delta time to tail flick, vehicle, before/after SA0.80.82.91.20.9-1.0-0.90.9-0.90.5-1.0-0.9-1.0-0.71.7-0.80.81.60.6-0.6-0.6-0.5-0.30.4
Delta time to tail flick, test, before/after SA0.30.41.8-0.7-1.00.80.4-0.40.8-0.30.60.50.70.5-0.80.7-0.7-1.3-0.50.50.30.3-0.1-0.3
Tibia length0.20.51.2-0.6-0.70.60.5-0.40.5-0.40.80.90.91.0-0.50.9-0.7-0.3-1.10.80.90.90.9-0.4
Ambulatory time before self-admin0.20.72.01.10.4-0.7-0.60.6-0.60.3-0.9-1.0-1.0-1.00.7-1.00.80.70.8-0.6-1.0-0.7-0.91.4
Ambulatory time after self-admin2.94.66.92.42.0-2.2-2.42.3-2.01.6-2.6-2.6-2.6-2.61.9-2.51.91.61.8-1.8-2.2-1.8-1.61.8
Bone: tissue strength0.10.10.50.30.5-0.4-0.30.4-0.50.6-0.2-0.1-0.20.00.40.00.20.40.0-0.10.30.20.5-0.7
Total heroin consumption0.10.10.6-0.3-0.30.20.1-0.10.4-0.80.10.10.1-0.00.2-0.20.10.60.4-0.2-0.4-0.4-0.60.3
Bone: trabecular number1.22.33.71.91.5-1.7-1.91.9-1.61.7-1.9-1.9-1.8-1.71.5-1.51.31.11.2-1.3-1.2-1.2-0.80.6
Bone: trabecular spacing1.72.53.7-1.7-1.51.41.7-1.71.4-1.61.81.91.81.9-1.51.8-1.4-1.0-1.31.61.71.61.4-1.0
Bone: trabecular thickness0.91.22.51.51.3-1.6-1.41.4-1.51.3-1.4-1.4-1.3-1.11.2-0.90.90.80.4-0.5-0.4-0.20.10.2
Bone: trabecular tissue density0.50.92.61.11.6-1.2-0.90.8-1.31.3-1.1-1.1-1.0-1.01.1-0.90.90.20.7-0.7-0.5-0.40.00.6
Water consumed over 24 hours0.61.22.90.60.3-0.5-0.70.8-0.2-0.2-1.0-1.1-1.2-1.21.1-1.21.21.31.6-1.0-1.6-1.4-1.71.5
Number of responses in last shaping day0.30.41.7-0.5-0.30.30.4-0.40.10.30.50.40.50.4-1.30.6-0.8-1.3-0.70.60.60.70.6-1.2