Nmu

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Nmu	0.06	0.04	5.6e-03	0.05	0.04	0.05	0.04	1.7e-03	2.9e-03	7.2e-04	3.1e-03
2	NAcc	gene expression	Nmu	0.06	0.04	1.8e-07	0.04	0.06	0.05	0.06	5.6e-06	5.5e-08	3.7e-06	3.9e-07
3	Brain	gene expression	Nmu	0.03	0.02	8.9e-03	0.01	0.02	0.01	0.01	7.4e-02	3.1e-03	2.0e-02	1.2e-02
4	Eye	gene expression	Nmu	0.46	0.2	1.3e-04	0.07	0.15	0.04	0.09	2.9e-02	2.3e-03	9.8e-02	1.6e-02
5	Eye	mRNA stability	Nmu	0.23	0.13	6.1e-03	0.09	0.12	0.01	0.05	1.8e-02	6.0e-03	2.0e-01	5.8e-02
6	Adipose	gene expression	Nmu	0.1	0.07	1.8e-04	0.04	0.03	0.04	0.03	3.7e-05	1.4e-04	2.8e-05	9.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.3	0.7	0.6	-0.8	-0.7	0.3	0.4	0.0
Area under the delay curve	0.4	0.4	0.7	0.5	-0.8	-0.8	-0.5	-0.5	0.8
BMI with tail	0.1	0.4	0.8	-0.6	0.3	0.5	0.8	0.9	-0.1
BMI without tail	0.2	0.4	0.8	-0.1	0.5	0.5	0.8	0.9	0.4
Body weight	0.1	0.4	0.9	0.3	0.5	0.4	0.9	1.0	-0.2
Weight adjusted by age	0.4	0.4	0.7	-0.7	0.8	0.6	0.6	0.7	-0.5
Bone surface	0.1	0.1	0.5	0.7	-0.1	-0.2	0.2	0.3	0.2
Bone volume	0.1	0.2	0.7	-0.2	-0.1	0.0	0.8	0.8	-0.1
Breakpoint value in progressive ratio session	1.2	1.3	1.8	1.1	-1.1	-1.1	-1.3	-1.3	0.8
Number of licking bursts	0.1	0.1	0.3	0.5	0.3	0.1	0.4	0.4	0.0
Context. condit. distance diff. score	4.4	5.4	7.2	-2.7	2.3	2.4	2.3	2.3	-1.9
Locomotion velocity, session 1	0.4	0.4	0.8	-0.4	0.9	0.7	0.5	0.5	-0.8
Locomotion distance, session 1	0.3	0.4	0.9	-0.8	0.9	0.7	0.2	0.2	-0.8
Locomotion velocity, session 2	0.4	0.5	0.8	0.3	-0.7	-0.6	-0.8	-0.8	0.9
Locomotion distance, session 2	1.6	2.2	3.6	0.9	-1.5	-1.5	-1.9	-1.9	0.9
Locomotion velocity, session 3	0.8	0.9	1.3	-0.9	1.0	1.1	1.0	1.0	0.2
Locomotion distance, session 3	1.4	1.5	2.5	-1.6	1.4	1.5	1.0	1.0	-0.7
Stereotopy head waving bouts, day 3	0.6	0.7	1.9	-1.0	-1.4	-0.7	-0.4	-0.5	0.7
Stereotopy head waving duration, day 3	2.3	2.7	10.5	-3.2	0.9	1.5	0.9	0.8	-1.1
Locomotion velocity, session 7	3.4	3.7	5.4	-2.3	1.6	1.9	2.3	2.3	-0.2
Locomotion distance, session 7	3.3	4.2	6.5	-2.6	2.4	2.6	1.8	1.7	-0.5
Stereotopy head waving bouts, day 7	1.7	2.0	6.9	-2.6	0.9	1.3	0.9	0.8	-1.0
Stereotopy head waving duration, day 7	3.3	4.0	6.8	1.4	-2.6	-2.4	-1.7	-1.7	1.9
Locomotion velocity, session 8	0.3	0.4	0.6	0.8	-0.6	-0.6	-0.6	-0.5	0.3
Locomotion distance, session 8	1.2	1.8	3.7	-1.9	1.5	1.5	1.0	1.0	-0.9
Degree of sensitization distance	1.6	1.6	2.7	-1.7	1.1	1.4	1.3	1.2	-0.1
Degree of sensitization stereotypy	1.6	1.7	2.6	1.2	-1.6	-1.6	-1.0	-1.0	1.3
Conditioned locomotion	0.3	0.3	0.9	-0.4	-1.0	-0.7	-0.4	-0.5	0.3
Cocaine response after cond. corrected	0.3	0.4	0.6	0.3	-0.7	-0.6	-0.8	-0.8	0.3
Cocaine response after cond. not corrected	0.1	0.2	0.3	0.5	-0.0	-0.2	-0.6	-0.5	-0.0
Cocaine response before conditioning	0.2	0.3	0.7	0.1	0.8	0.5	0.3	0.4	-0.7
Saline control response	0.2	0.3	0.6	0.1	0.4	0.3	0.8	0.8	0.3
Bone: connectivity density	2.4	3.8	6.8	2.6	-2.1	-2.3	-1.7	-1.6	1.0
Bone: cortical apparent density	0.6	0.8	2.5	0.9	-0.9	-0.7	0.1	0.2	1.6
Bone: cortical area	0.9	1.4	3.0	-0.5	1.1	1.0	1.7	1.7	-0.1
Bone: cortical porosity	1.1	1.2	2.1	0.8	-1.4	-1.3	-0.9	-0.9	1.2
Bone: cortical porosity	0.9	1.0	2.2	0.7	-1.5	-1.3	-0.6	-0.6	1.1
Bone: cortical thickness	1.1	1.9	4.1	-0.4	1.3	1.2	2.0	2.0	0.3
Bone: cortical thickness	0.0	0.0	0.1	-0.0	-0.3	-0.3	0.2	0.2	0.1
Bone: cortical tissue density	0.6	0.8	2.5	0.9	-0.9	-0.7	0.0	0.1	1.6
Condit. Reinf. active minus inactive responses	0.3	0.4	0.9	-0.6	-0.3	-0.2	-0.6	-0.6	-0.9
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.7	-1.3	0.1	0.4	0.4	0.4	-0.9
Condit. Reinf. active responses	0.7	0.9	1.8	-0.1	-0.9	-0.8	-1.4	-1.3	-0.6
Condit. Reinf. inactive responses	0.6	0.7	1.2	0.8	-0.7	-0.8	-1.1	-1.1	0.1
Incentive salience index mean	0.8	0.9	1.8	0.5	-0.8	-1.0	-1.3	-1.3	-0.6
Condit. Reinf. lever presses	2.1	2.9	4.8	2.2	-1.3	-1.8	-2.0	-1.9	-0.1
Condit. Reinf. active minus inactive responses	0.3	0.3	1.7	0.1	0.3	-0.0	0.4	0.4	-1.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.9	-0.0	-0.1	-0.3	0.2	0.2	-1.0
Condit. Reinf. active responses	0.5	0.7	1.2	-0.5	0.8	0.6	0.9	0.9	-1.1
Condit. Reinf. inactive responses	1.1	1.4	2.4	-0.9	1.5	1.5	1.2	1.2	-0.5
Condit. Reinf. lever presses	0.6	0.8	2.0	1.4	-0.5	-0.9	-0.9	-0.9	-0.0
Condit. Reinf. lever reinforcers received	0.2	0.3	0.8	-0.1	0.5	0.3	0.5	0.5	-0.9
Conditioned reinforcement - actives	0.0	0.0	0.1	0.3	0.2	0.2	0.1	0.1	0.0
Conditioned reinforcement - inactives	1.4	1.6	3.1	0.9	-1.1	-1.2	-1.8	-1.7	0.2
Conditioned locomotion	0.1	0.1	0.5	0.2	0.7	0.4	0.1	0.3	-0.1
Patch foraging indifference point 0 sec	2.0	3.1	5.3	-1.5	2.3	2.3	1.7	1.7	-0.5
Patch foraging indifference point AUC	2.8	3.3	7.7	-1.6	2.0	1.8	0.9	1.0	-2.8
Delay disc. indifference point, 0s delay	0.3	0.3	0.4	0.6	-0.3	-0.6	-0.6	-0.6	0.4
Delay disc. indifference point, 16s delay	0.9	0.9	1.7	0.8	-1.3	-1.2	-0.7	-0.6	1.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.2	-0.3	-0.1	0.3	0.2	0.3
Delay disc. indifference point, 24s delay	0.4	0.4	0.9	0.4	-0.8	-0.7	-0.3	-0.3	0.9
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	0.3	-0.8	-0.9	-0.5	-0.5	0.4
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	0.1	-0.5	-0.5	-0.3	-0.3	0.6
Indifference point function ln k	1.5	2.1	5.1	0.9	-1.6	-1.4	-0.9	-1.0	2.3
Indifference point function log k	1.5	2.1	5.1	0.9	-1.6	-1.4	-0.9	-1.0	2.3
Patch foraging total patch changes 0 sec	3.3	5.2	8.1	-2.1	2.8	2.8	2.3	2.3	-0.6
Patch foraging total patch changes 12 sec	1.6	2.0	3.2	-0.9	1.8	1.6	1.2	1.2	-1.7
Patch foraging total patch changes 18 sec	5.2	6.7	9.4	-2.2	3.1	2.8	2.3	2.3	-2.8
Patch foraging total patch changes 24 sec	3.4	4.2	7.2	-1.6	2.7	2.5	1.8	1.9	-1.5
Patch foraging total patch changes 6 sec	3.0	4.4	7.4	-1.8	2.7	2.4	1.4	1.5	-2.4
Patch foraging time to switch 0 sec	1.6	2.4	6.7	2.6	-1.3	-1.6	-1.1	-1.0	1.2
Patch foraging water rate 0 sec	0.4	0.6	1.7	-1.3	0.6	0.7	0.4	0.3	-0.9
Patch foraging water rate 12 sec	0.4	0.6	1.9	-1.3	0.1	0.2	0.1	0.0	-1.4
Patch foraging water rate 18 sec	1.2	1.7	2.9	0.2	-1.7	-1.3	-1.4	-1.4	1.3
Patch foraging water rate 24 sec	0.3	0.4	0.9	-0.5	-1.0	-0.6	-0.4	-0.4	0.6
Patch foraging water rate 6 sec	0.4	0.5	1.9	-1.4	-0.4	-0.1	-0.2	-0.3	-1.0
Seeking ratio, delayed vs. immediate footshock	2.1	2.4	4.0	1.4	-1.3	-1.5	-2.0	-2.0	0.8
Distance traveled before self-admin	0.4	0.4	0.6	0.5	0.7	0.4	0.6	0.7	-0.8
Distance traveled after self-admin	0.2	0.2	0.5	0.4	0.2	0.2	0.7	0.6	-0.0
Extensor digitorum longus weight	1.5	5.8	13.1	3.6	-2.2	-2.9	-2.0	-1.9	0.8
Bone: elastic displacement	0.1	0.2	0.6	-0.8	-0.0	0.1	0.4	0.4	-0.3
Bone: elastic work	0.1	0.1	0.3	-0.3	0.1	0.2	0.5	0.5	0.3
Bone: endosteal estimation	0.3	0.6	1.4	-0.5	0.6	0.5	0.8	0.8	-1.2
Bone: endosteal perimeter	0.3	0.5	2.8	-0.2	0.6	0.2	0.2	0.2	-1.7
Epididymis fat weight	0.7	1.6	4.1	-0.2	2.0	1.6	0.8	0.8	-1.4
Delta time in closed arm before/after self-admin	0.7	0.7	1.1	-0.9	1.0	1.1	0.7	0.8	-0.4
Delta time in open arm before/after self-admin	0.2	0.2	1.0	1.0	-0.2	-0.3	0.0	-0.1	0.4
Diff in mean of infusions in LGA sessions	0.6	0.6	1.0	0.3	-1.0	-0.8	-1.0	-1.0	0.1
Delay discount exponential model param	0.2	0.2	0.5	-0.3	0.6	0.6	0.2	0.2	-0.7
Extinction: sum of active levers before priming	0.2	0.2	0.4	0.1	0.4	0.2	-0.7	-0.6	-0.3
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.3	0.2	0.4	0.3	0.2	0.3
Bone: final force	0.2	0.3	0.4	0.5	-0.4	-0.5	0.5	0.6	-0.5
Bone: final moment	0.2	0.3	0.7	0.7	-0.7	-0.8	0.3	0.4	-0.3
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.5	0.1	0.2	-0.0	-0.1	-0.4
Glucose	0.1	0.2	0.7	-0.1	-0.3	-0.3	0.0	0.1	-0.9
Heart weight	0.1	0.1	0.3	-0.3	-0.2	-0.2	-0.5	-0.5	-0.2
Delay discount hyperbolic model param	0.3	0.3	0.5	-0.4	0.7	0.7	0.3	0.3	-0.7
Intermittent access intake day 1-15 change	1.7	1.7	3.4	1.2	-1.8	-1.4	-0.8	-0.9	1.4
Intermittent access intake escalation	1.3	1.2	2.4	1.1	-1.5	-1.2	-0.7	-0.8	1.1
Intermittent access intake escalation 2	2.4	2.4	3.7	1.6	-1.9	-1.8	-1.3	-1.4	1.3
Intermitt. access day 1 inactive lever presses	5.5	5.9	7.4	-2.7	2.5	2.7	2.3	2.2	-2.0
Intermitt. access day 15 inactive lever presses	0.6	0.7	1.4	0.3	-0.8	-0.7	-1.2	-1.2	0.3
Intermitt. access escalation Index	0.3	0.3	0.7	-0.6	0.3	0.3	0.4	0.4	-0.8
Intermittent access day 1 total infusions	0.4	0.5	1.3	0.5	-0.3	-0.5	-1.1	-1.1	0.1
Intermittent access day 15 total infusions	2.3	2.6	3.5	1.5	-1.9	-1.7	-1.7	-1.8	0.9
Intermittent access terminal intake (last 3 days)	4.0	4.3	5.9	1.7	-2.4	-2.2	-2.3	-2.4	1.1
Intermittent access total infusions	1.6	1.7	2.4	1.3	-1.3	-1.4	-1.5	-1.5	0.8
Intermittent access day 1 locomotion	0.1	0.2	0.4	-0.2	0.6	0.5	-0.1	-0.1	-0.5
Intermittent access day 15 total locomotion	1.2	1.3	2.1	1.1	-1.0	-1.0	-1.4	-1.5	0.9
Intermittent access total locomotion	0.1	0.1	0.2	0.3	0.0	-0.1	-0.4	-0.4	0.5
Intermittent access standard deviation	0.4	0.4	1.4	1.2	-0.4	-0.5	-0.1	-0.2	0.7
Left kidney weight	0.3	0.8	2.0	0.3	0.6	0.4	1.4	1.4	0.2
Right kidney weight	0.5	1.3	2.1	-0.5	1.4	1.1	1.1	1.2	-1.2
Cocaine induced anxiety	0.3	0.4	0.7	0.2	-0.9	-0.8	-0.5	-0.4	0.6
Post-drug Anxiety	0.1	0.1	0.3	-0.1	0.0	0.1	0.3	0.4	0.5
Baseline Anxiety	0.0	0.1	0.1	0.3	-0.1	-0.1	-0.2	-0.3	0.3
Tail length	0.2	0.5	0.8	0.6	0.9	0.6	0.8	0.8	0.4
Length with tail	0.1	0.4	0.7	0.7	0.8	0.4	0.6	0.6	-0.3
Length without tail	0.2	0.4	0.9	-0.0	0.8	0.5	0.7	0.6	-0.9
Times rat made contact with spout	0.1	0.2	0.6	0.3	0.4	0.1	0.1	0.2	-0.8
Lifetime Intake	1.5	1.7	2.4	1.5	-1.3	-1.3	-1.4	-1.4	0.9
Liver weight, left	0.7	1.1	3.3	-1.1	0.7	0.7	0.8	0.8	-1.8
Liver weight, right	0.0	0.1	0.1	0.3	-0.3	-0.3	-0.2	-0.2	-0.2
Locomotor activity	4.3	6.9	9.9	-2.7	3.2	3.0	2.1	2.0	-2.6
Locomotor testing distance	3.9	6.5	10.7	-2.1	3.3	2.9	2.2	2.1	-2.6
Locomotor testing rearing	1.9	3.0	5.3	-1.1	2.3	2.1	1.6	1.5	-1.5
Locomotion in novel chamber	1.6	2.0	2.9	1.6	-1.3	-1.4	-1.6	-1.7	0.6
Locomotion in novel chamber post-restriction	0.2	0.3	0.6	-0.3	0.6	0.4	0.4	0.5	-0.8
Fecal boli incidents, locomotor time 1	3.2	3.5	5.8	-1.5	2.4	2.2	1.7	1.7	-1.5
Change in fecal boli incidents, locomotor task	1.3	1.3	1.8	1.1	-1.3	-1.4	-1.1	-1.1	0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.4	0.1	-0.0	0.0	-0.0	0.4
Bouts of movement, locomotor time 1	0.2	0.2	0.7	-0.6	0.2	0.3	0.4	0.4	-0.8
Total resting periods, locomotor time 1	0.3	0.3	0.6	-0.6	0.3	0.4	0.7	0.8	-0.6
Rest time, locomotor task time 1	1.5	1.7	3.0	-1.7	1.1	1.3	1.1	1.1	-1.3
Distance moved, locomotor task time 1	1.4	1.6	2.3	1.0	-1.5	-1.5	-1.1	-1.1	1.2
Vertical activity count, locomotor time 1	3.9	4.1	5.6	2.0	-2.2	-2.4	-2.1	-2.1	1.0
Time >=10cm from walls, locomotor time 2	1.8	1.9	2.5	1.1	-1.5	-1.6	-1.5	-1.5	0.6
Bouts of movement, locomotor time 2	0.5	0.5	1.4	-1.2	0.5	0.8	0.6	0.5	-0.6
Total resting periods, locomotor time 2	1.1	1.2	2.8	-1.7	0.9	1.2	0.9	0.9	-0.9
Rest time, locomotor task time 2	4.9	5.6	7.8	-2.8	2.4	2.5	2.0	1.9	-2.4
Distance moved, locomotor task time 2	6.7	7.8	9.1	3.0	-2.9	-3.0	-2.5	-2.5	2.8
Vertical activity count, locomotor time 2	9.3	10.1	11.8	3.1	-3.1	-3.4	-3.4	-3.4	2.5
Light reinforcement 1	0.2	0.4	0.6	-0.8	0.6	0.7	0.6	0.7	-0.5
Light reinforcement 2	0.8	1.1	1.8	-1.3	1.1	1.1	0.8	0.8	-1.1
Bone: marrow area	0.2	0.4	1.1	-0.4	0.5	0.4	0.7	0.7	-1.1
Bone: maximum diameter	0.6	1.1	2.0	-0.6	1.1	0.9	1.0	1.0	-1.4
Bone: maximum force	0.3	0.6	1.4	0.2	0.5	0.3	1.1	1.2	-0.7
Bone: maximum moment	0.2	0.3	0.9	0.3	0.2	0.0	0.9	0.9	-0.5
Mean time between licks in bursts	2.3	3.2	6.3	-2.5	1.6	1.9	1.7	1.7	-1.2
Mean num. licks in bursts	0.1	0.2	0.5	-0.5	-0.0	0.0	-0.3	-0.4	-0.7
Cd content in liver	0.1	0.1	0.4	-0.6	0.1	0.4	0.1	0.1	0.5
Co content in liver	2.3	2.7	4.3	2.1	-1.6	-1.9	-1.5	-1.5	1.1
Cu content in liver	0.2	0.2	1.2	-0.1	0.4	0.3	-0.2	-0.1	-1.1
Fe content in liver	0.4	0.5	0.8	-0.5	-0.8	-0.5	-0.9	-0.9	-0.2
K content in liver	3.5	3.5	5.2	-1.5	1.9	2.0	2.2	2.3	-0.8
Mg content in liver	3.4	3.5	4.8	-2.2	1.7	1.8	1.9	1.9	-1.8
Mn content in liver	5.0	5.7	7.8	2.6	-2.8	-2.8	-2.0	-2.0	2.0
Na content in liver	0.9	0.9	1.4	1.0	-0.6	-0.8	-1.2	-1.2	-0.9
Rb content in liver	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.1	-0.0	-0.4
Se content in liver	0.9	1.1	2.2	0.4	-1.5	-1.2	-1.1	-1.1	0.4
Sr content in liver	0.2	0.2	0.5	0.7	0.3	0.2	0.1	0.2	-0.6
Zn content in liver	0.4	0.5	1.9	-1.0	-0.2	0.0	0.0	0.0	-1.4
Bone: minimum diameter	1.0	1.8	3.1	-1.0	1.2	1.2	1.7	1.8	-0.9
Time in familiar zone, hab. session 1	0.2	0.2	0.5	0.4	-0.0	-0.3	-0.7	-0.7	0.3
Time in novel zone, hab. session 1	0.3	0.2	0.5	-0.6	0.2	0.4	0.7	0.6	-0.2
Total zone transitions, hab. session 1	0.5	0.8	1.3	0.4	-0.8	-1.0	-1.1	-1.1	-0.5
Total locomotion distance, hab. session 1	11.6	16.4	36.7	-6.1	3.6	3.9	2.5	2.4	-4.6
Locomotion velocity, hab. session 1	10.8	15.3	32.5	-5.7	3.6	3.9	2.5	2.4	-4.4
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.2	-0.0	0.0	-0.2	-0.2	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.4	0.5	-0.4	-0.4	-0.1	-0.1	0.6
Total zone transitions, hab. session 2	0.1	0.2	0.9	0.3	0.2	-0.3	-0.2	-0.1	-0.9
Total locomotion distance, hab. session 2	10.1	13.4	24.0	-4.9	3.6	3.6	2.5	2.5	-4.2
Locomotion velocity, hab. session 2	9.4	12.7	22.2	-4.7	3.6	3.6	2.4	2.4	-4.1
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.5	-0.5	-0.3	-0.2	-0.3	0.2
Novelty place preference	0.3	0.3	0.6	0.0	-0.8	-0.6	-0.6	-0.7	0.5
Time in novel zone, NPP test	0.7	0.7	1.3	0.2	-1.1	-0.9	-0.8	-0.9	0.8
Total zone transitions, NPP test	0.6	0.8	1.3	-0.6	1.2	0.8	0.7	0.8	-1.2
Total locomotion distance, NPP test	12.6	17.2	30.0	-5.5	4.3	4.5	3.2	3.2	-3.7
Locomotion velocity, NPP test	13.4	18.9	32.0	-5.7	4.6	4.8	3.4	3.4	-3.9
Intraocular pressure	0.9	1.3	3.4	-0.7	-1.4	-0.7	-0.8	-0.9	1.8
Delta distance traveled before/after self-admin	0.3	0.3	0.8	-0.5	0.1	0.5	0.9	0.7	0.4
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.6	0.1	0.3	0.4	0.3	-0.1
Parametrial fat weight	1.7	3.4	4.5	-2.0	2.1	2.0	1.4	1.4	-2.0
Pavlov. Cond. lever latency	0.3	0.4	0.8	-0.3	0.5	0.7	0.6	0.5	0.9
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.4	-0.1	-0.1	-0.4	-0.4	-0.3
Pavlov. Cond. change in total contacts	0.8	0.9	1.2	0.7	-0.9	-1.1	-1.1	-1.1	-0.5
Pavlov. Cond. index score	0.3	0.4	0.6	-0.0	-0.5	-0.6	-0.8	-0.7	-0.7
Pavlov. Cond. latency score	0.1	0.2	0.6	-0.2	-0.2	-0.3	-0.4	-0.3	-0.8
Pavlov. Cond. lever contacts	0.5	0.6	1.1	0.3	-0.9	-1.1	-0.9	-0.8	-0.7
Pavlov. Cond. magazine entry number	0.5	0.6	1.2	0.3	0.7	0.7	1.1	1.1	0.8
Pavlov. Cond. intertrial magazine entries	1.9	2.3	3.2	1.2	-1.6	-1.7	-1.8	-1.8	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.1	0.2	-0.8	-0.9	-1.0	-1.0	-0.5
Pavlov. Cond. response bias	0.7	0.8	1.3	0.4	-0.9	-1.0	-1.1	-1.1	-0.6
Pavlov. Cond. lever latency	0.4	0.6	1.1	-0.9	0.4	0.7	1.0	1.0	-0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.8	0.9	-0.3	-0.6	-0.7	-0.7	-0.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.5	0.0	-0.2	-0.3	-0.4	0.4
Pavlov. Cond. index score	0.5	0.7	1.3	1.1	-0.3	-0.7	-1.1	-1.1	0.3
Pavlov. Cond. latency score	0.5	0.6	1.2	1.1	-0.3	-0.6	-1.0	-1.0	0.2
Pavlov. Cond. lever contacts	0.4	0.6	1.1	1.0	-0.4	-0.7	-1.0	-1.0	0.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.6	-0.8	0.4	0.6	0.7	0.8	-0.4
Pavlov. Cond. intertrial magazine entries	1.6	2.1	2.6	-1.6	1.5	1.6	1.5	1.6	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	1.0	-0.1	-0.4	-0.8	-0.8	0.3
Pavlov. Cond. response bias	0.6	0.9	1.5	1.1	-0.6	-0.9	-1.2	-1.2	0.0
Time in closed arm before self-admin	0.3	0.4	1.5	0.7	-0.0	-0.0	0.3	0.2	1.2
Time in closed arm after self-admin	0.7	0.7	1.4	-0.6	0.7	0.9	0.8	0.8	1.2
Time in open arm before self-admin	2.6	2.8	5.1	-2.3	1.6	1.6	1.2	1.2	-2.0
Time in open arm after self-admin	0.5	0.6	2.1	-0.4	0.8	0.7	0.4	0.3	-1.5
Bone: periosteal estimation	0.6	1.3	2.7	-0.6	1.1	1.0	1.6	1.6	-0.6
Bone: periosteal perimeter	0.5	0.8	1.8	-0.4	1.1	0.8	0.8	0.8	-1.3
Bone: post-yield work	0.1	0.2	1.0	0.2	-0.0	-0.2	-0.3	-0.3	-1.0
Progressive ratio test 1 active lever presses	0.3	0.3	0.5	0.4	-0.7	-0.6	-0.5	-0.6	0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.0	-0.5	-0.3	-0.2	-0.2	0.1
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.5	-0.7	-0.5	-0.3	-0.5	-0.5	-0.1
Progressive ratio test 2 active lever presses	1.5	1.6	2.0	1.2	-1.2	-1.2	-1.3	-1.4	1.2
Progressive ratio test 2 breakpoint	0.8	0.9	1.1	0.9	-0.9	-0.9	-0.9	-1.0	1.0
Progressive ratio test 2 inactive lever presses	1.8	2.1	3.8	1.0	-1.5	-1.4	-1.8	-1.9	0.5
Incentive Sensitization - Responses	3.3	3.3	5.1	1.5	-2.1	-1.9	-1.5	-1.6	2.2
Incentive Sensitization - Breakpoint	3.0	3.1	4.5	1.4	-2.0	-1.8	-1.5	-1.6	2.1
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.2	1.1	-0.5	-0.6	-0.2	-0.2	0.4
Progressive ratio	3.2	3.8	6.6	-0.9	2.6	2.4	2.2	2.1	-0.5
Food seeking constrained by brief footshock	2.4	2.9	4.3	-1.3	1.9	1.7	2.1	2.1	-0.8
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	-0.1	-0.8	-0.7	-0.4	-0.4	-0.4
Retroperitoneal fat weight	0.5	1.6	2.9	-0.8	1.7	1.6	1.2	1.2	-1.0
Reaction time number correct	0.3	0.5	0.9	-0.6	-0.3	0.0	0.9	0.9	0.8
Reaction time mean minus median	1.6	2.1	3.8	1.9	-1.5	-1.5	-1.4	-1.3	0.9
Reaction time mean minus median AUC	2.7	3.5	5.8	2.4	-2.0	-2.1	-1.8	-1.8	0.8
Reaction time num false alarms	0.2	0.3	0.6	0.8	-0.3	-0.4	-0.7	-0.7	0.2
Reaction time num false alarms AUC	0.2	0.3	0.7	0.8	-0.2	-0.4	-0.7	-0.6	-0.1
Reaction time trials correct on left	0.3	0.5	0.9	-0.6	-0.3	0.0	0.9	0.9	0.8
Reaction time trials on left	0.3	0.4	0.8	-0.5	-0.4	-0.0	0.9	0.8	0.9
Reaction time mean	1.9	2.7	4.7	2.2	-1.7	-1.8	-1.3	-1.2	1.5
Reaction time mean AUC	2.0	2.7	4.7	2.2	-1.7	-1.8	-1.4	-1.3	1.2
Median of all reaction times	1.7	2.3	3.7	1.9	-1.6	-1.7	-1.1	-1.0	1.6
Reaction time omissions	2.7	3.7	7.6	2.8	-1.8	-1.9	-1.3	-1.2	2.3
Reaction time false alarm rate	0.5	0.7	1.5	1.0	-0.0	-0.4	-1.2	-1.2	-0.5
Reaction time premature initiation rate	4.7	6.3	8.3	2.6	-2.9	-2.8	-2.5	-2.4	1.7
Reaction time premature initiations	3.0	4.2	6.8	2.0	-2.6	-2.4	-1.6	-1.5	1.9
Std. dev. reaction times	1.4	1.9	4.5	2.1	-1.3	-1.5	-1.2	-1.1	0.8
Reaction time trials completed	0.3	0.4	0.8	-0.5	-0.4	-0.0	0.9	0.8	0.9
Reaction time trials AUC	0.3	0.4	0.8	-0.4	-0.4	-0.1	0.8	0.8	0.9
Run reversals in cocaine runway, females	0.2	0.2	0.8	0.2	-0.5	-0.4	-0.3	-0.1	0.9
Run reversals in cocaine runway, males	0.9	0.9	1.6	-1.1	0.5	0.7	1.2	1.3	-0.3
Latency to leave start box in cocaine runway	3.0	3.3	4.6	-1.3	2.1	2.1	2.0	2.0	-0.7
Latency to leave start box in cocaine runway, F	0.9	1.0	1.4	-1.0	1.1	1.2	1.1	1.1	-0.2
Latency to leave start box in cocaine runway, M	2.7	2.6	4.1	-1.2	2.0	1.9	1.7	1.6	-1.1
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.5	-0.2	-0.1	-0.4	-0.4	-0.2
Total sessions with >9 infusions	0.2	0.3	0.8	0.3	-0.4	-0.3	-0.5	-0.5	0.9
Short access day 1 total inactive lever presses	0.8	0.9	1.8	-0.8	1.4	1.3	0.4	0.3	-1.0
Short access day 10 total inactive lever presses	2.6	2.9	3.8	-1.8	2.0	1.9	1.5	1.6	-1.4
Short access day 1 total infusions	0.9	1.0	1.9	1.4	-1.0	-0.9	-0.8	-0.9	0.8
Short access day 10 total infusions	1.6	1.7	2.2	1.3	-1.2	-1.3	-1.5	-1.5	1.1
Short access total infusions	0.6	0.7	1.3	1.1	-0.6	-0.7	-0.8	-0.8	0.8
Short access day 1 locomotion	0.4	0.4	1.5	0.3	0.8	0.5	-0.0	0.0	-1.2
Short access day 10 total locomotion	0.3	0.3	0.7	-0.5	0.8	0.8	0.5	0.5	0.2
Short access total locomotion	0.4	0.4	1.2	-0.3	1.1	0.9	0.3	0.4	-0.6
One hour access (0.3 mA shock)	1.4	1.7	3.0	0.9	-1.1	-1.3	-1.7	-1.7	0.4
Compulsive drug intake	2.1	2.1	2.9	-1.6	1.5	1.5	1.2	1.2	-1.7
One hour access (shock baseline)	3.4	3.9	4.6	2.1	-1.9	-2.1	-2.1	-2.1	1.4
Social response proportion	0.4	0.4	1.8	1.3	0.3	-0.3	-0.3	-0.2	0.5
Social responses	1.1	1.4	3.0	-0.3	1.7	1.3	1.2	1.3	-0.7
Social time	0.4	0.5	1.2	0.8	-0.6	-0.8	-0.2	-0.1	1.1
Soleus weight	0.3	1.0	1.4	1.2	-0.9	-1.0	-1.0	-1.0	0.8
Bone: stiffness	0.4	0.6	1.4	-0.0	0.6	0.5	1.1	1.2	-0.4
Tibialis anterior weight	0.8	2.6	4.4	2.0	-2.0	-2.1	-1.3	-1.2	0.7
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.3	0.7	-0.5	-0.7	-1.1	-1.1	0.2
Time to tail flick, vehicle, after self-admin	4.1	4.4	6.2	-2.4	2.4	2.5	2.0	2.0	-0.8
Time to tail flick, test, before self-admin	0.2	0.2	0.6	-0.8	0.1	0.3	0.2	0.1	-0.6
Time to tail flick, test, after self-admin	0.9	1.0	2.0	-0.8	1.4	1.2	0.9	0.9	-0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	-0.2	0.2	0.3	0.8	0.7	0.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.4	0.4	0.2	-0.0	-0.1	0.5
Tibia length	0.0	0.1	0.5	0.7	0.1	-0.3	0.1	0.1	-0.2
Ambulatory time before self-admin	0.3	0.3	0.7	0.6	0.4	0.2	0.7	0.9	-0.3
Ambulatory time after self-admin	0.1	0.2	0.2	0.5	-0.3	-0.3	0.4	0.4	0.3
Bone: tissue strength	1.3	1.2	1.8	-0.5	1.3	1.2	1.3	1.3	-0.7
Total heroin consumption	0.1	0.1	0.2	0.3	-0.3	-0.2	-0.4	-0.4	0.3
Bone: trabecular number	0.1	0.1	0.2	0.4	-0.3	-0.3	0.4	0.4	-0.1
Bone: trabecular spacing	0.0	0.1	0.2	-0.4	0.2	0.2	-0.0	-0.0	0.3
Bone: trabecular thickness	0.4	0.5	1.6	-0.0	-1.3	-0.9	-0.3	-0.4	-0.3
Bone: trabecular tissue density	1.3	1.9	3.1	-1.5	1.0	1.2	1.7	1.7	-0.9
Water consumed over 24 hours	1.1	1.3	1.9	1.1	-1.3	-1.4	-1.2	-1.2	0.1
Number of responses in last shaping day	0.3	0.3	0.5	-0.5	0.6	0.7	0.2	0.1	-0.7