Hub : Genes

Nfkbie

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Nfkbie	0.03	0.02	7.0e-03	0.01	0.03	0.02	0.01	4.1e-02	1.7e-03	1.2e-02	1.9e-02
2	pVTA	gene expression	Nfkbie	0.12	0.06	6.2e-04	0.08	0.09	0.08	0.1	3.1e-04	1.0e-04	2.2e-04	6.5e-05
3	IL	gene expression	Nfkbie	0.24	0.11	2.0e-04	0.06	0.09	0.05	0.05	1.8e-02	3.7e-03	2.2e-02	2.1e-02
4	BLA	gene expression	Nfkbie	0.15	0.07	8.2e-05	0.04	0.04	0.05	0.06	3.9e-03	2.2e-03	7.7e-04	6.4e-04
5	PL	gene expression	Nfkbie	0.06	0.03	8.5e-07	0.03	0.04	0.04	0.04	1.2e-04	1.1e-05	1.7e-05	1.6e-05
6	NAcc	gene expression	Nfkbie	0.04	0.03	5.3e-03	0.01	0.01	0.02	0.01	5.8e-03	1.9e-02	2.5e-03	4.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.7	1.2	2.3	0.5	0.7	1.5	1.3	1.4	-0.6
Area under the delay curve	1.1	1.2	3.1	-1.6	1.8	0.3	-1.2	-0.0	0.3
BMI with tail	4.1	13.2	17.4	-1.6	-4.1	-4.2	-3.5	-4.1	3.7
BMI without tail	12.0	24.7	32.8	-1.9	-5.3	-5.7	-4.8	-5.7	5.3
Body weight	1.5	6.5	14.7	-0.2	-3.8	-2.3	-1.5	-2.5	3.2
Weight adjusted by age	0.1	0.1	0.4	-0.6	0.0	0.3	-0.0	0.2	0.1
Bone surface	2.7	4.7	8.4	0.3	2.2	2.9	2.1	2.7	-1.7
Bone volume	1.8	3.0	5.5	0.3	1.6	2.3	1.8	2.2	-1.3
Breakpoint value in progressive ratio session	0.1	0.1	0.3	-0.5	0.5	0.0	-0.2	0.0	0.2
Number of licking bursts	0.3	0.4	1.2	1.1	-0.8	0.1	0.6	0.1	0.2
Context. condit. distance diff. score	1.4	1.7	3.6	-1.0	-1.9	-1.5	-1.0	-1.3	1.0
Locomotion velocity, session 1	0.5	0.6	2.3	-1.5	0.8	0.2	-0.6	0.0	-0.0
Locomotion distance, session 1	0.4	0.5	1.5	-1.2	-0.1	-0.7	-0.7	-0.4	-0.7
Locomotion velocity, session 2	3.0	3.5	4.6	-1.8	-1.6	-2.1	-2.0	-2.1	1.6
Locomotion distance, session 2	0.8	1.1	2.3	-1.5	-0.4	-1.2	-1.4	-1.0	0.2
Locomotion velocity, session 3	0.8	1.0	1.7	-1.3	-0.0	-1.2	-1.2	-1.0	0.2
Locomotion distance, session 3	0.2	0.3	1.0	-1.0	0.4	-0.2	-0.6	-0.2	-0.2
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.4	-0.1	0.6	0.6	0.4	0.2
Stereotopy head waving duration, day 3	0.3	0.4	0.7	-0.4	-0.8	-0.7	-0.4	-0.7	0.7
Locomotion velocity, session 7	0.8	0.8	1.5	-0.5	1.2	0.9	0.5	0.9	-1.2
Locomotion distance, session 7	0.4	0.5	2.0	-1.4	0.4	-0.3	-0.7	-0.2	-0.5
Stereotopy head waving bouts, day 7	0.4	0.4	1.5	-0.4	-1.2	-0.3	-0.1	-0.4	0.7
Stereotopy head waving duration, day 7	0.1	0.1	0.3	0.4	-0.5	0.2	0.5	0.2	0.1
Locomotion velocity, session 8	0.5	0.6	1.3	-0.5	0.7	0.6	0.6	0.8	-1.2
Locomotion distance, session 8	1.2	1.8	3.4	-1.9	-1.0	-1.6	-1.5	-1.3	0.1
Degree of sensitization distance	0.2	0.2	0.6	-0.7	-0.2	-0.4	-0.5	-0.4	0.3
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.5	-0.6	-0.2	-0.2	-0.3	0.5
Conditioned locomotion	0.5	0.6	2.0	-1.1	1.4	0.3	-0.4	0.2	-0.2
Cocaine response after cond. corrected	0.4	0.4	1.0	1.0	-0.1	0.5	0.9	0.6	-0.3
Cocaine response after cond. not corrected	0.5	0.6	1.1	0.9	0.2	0.8	1.1	0.9	-0.4
Cocaine response before conditioning	0.4	0.5	1.1	-0.6	1.0	0.8	0.3	0.7	-0.5
Saline control response	0.1	0.1	0.2	-0.5	0.2	0.2	0.0	0.3	-0.4
Bone: connectivity density	1.0	1.6	3.3	0.7	1.1	1.8	1.4	1.6	-0.7
Bone: cortical apparent density	0.3	0.4	1.0	-0.0	0.5	1.0	0.6	0.8	-0.3
Bone: cortical area	0.4	0.5	1.1	-0.8	0.5	0.6	0.6	0.8	-1.1
Bone: cortical porosity	1.1	1.2	2.1	0.1	-1.0	-1.4	-0.9	-1.4	1.0
Bone: cortical porosity	0.7	0.8	1.8	-0.2	-0.7	-1.3	-0.9	-1.2	0.5
Bone: cortical thickness	0.3	0.6	2.0	-1.4	-0.4	-0.6	-0.7	-0.5	0.1
Bone: cortical thickness	0.5	0.6	0.8	0.4	0.7	0.9	0.8	0.9	-0.9
Bone: cortical tissue density	0.3	0.3	0.9	0.0	0.5	1.0	0.5	0.7	-0.3
Condit. Reinf. active minus inactive responses	1.4	1.6	4.2	0.2	0.8	1.0	1.4	1.4	-2.0
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.7	0.8	0.3	0.7	1.3	1.0	-1.3
Condit. Reinf. active responses	0.8	0.9	3.2	0.1	0.3	0.5	1.1	0.9	-1.8
Condit. Reinf. inactive responses	0.3	0.3	0.9	-0.1	-0.9	-0.7	-0.3	-0.5	0.2
Incentive salience index mean	0.5	0.6	2.8	-0.1	0.4	0.2	0.7	0.6	-1.7
Condit. Reinf. lever presses	0.4	0.5	1.3	-0.3	-0.7	-1.1	-0.6	-0.8	-0.0
Condit. Reinf. active minus inactive responses	0.4	0.5	1.2	-0.4	0.8	0.5	0.5	0.6	-1.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	-0.1	-0.0	0.5	0.6	0.6	-0.8
Condit. Reinf. active responses	0.5	0.6	1.9	-1.0	1.4	0.4	-0.1	0.4	-0.8
Condit. Reinf. inactive responses	0.5	0.6	2.0	-1.0	1.4	0.3	-0.6	0.0	0.1
Condit. Reinf. lever presses	0.1	0.2	0.5	-0.7	0.4	-0.3	-0.4	-0.3	-0.1
Condit. Reinf. lever reinforcers received	0.4	0.6	1.7	-1.0	1.3	0.3	-0.1	0.4	-0.9
Conditioned reinforcement - actives	0.3	0.3	1.6	-1.3	-0.1	-0.3	-0.3	-0.0	-0.5
Conditioned reinforcement - inactives	0.3	0.3	0.8	-0.9	-0.4	-0.6	-0.5	-0.4	0.3
Conditioned locomotion	0.0	0.0	0.1	0.0	-0.3	-0.1	0.1	0.0	0.0
Patch foraging indifference point 0 sec	0.8	1.3	2.7	-0.9	-1.1	-0.8	-1.1	-1.1	1.7
Patch foraging indifference point AUC	1.9	2.2	6.3	-2.5	0.4	-1.3	-1.8	-1.2	0.6
Delay disc. indifference point, 0s delay	0.9	1.0	2.0	-1.4	1.3	0.6	-0.3	0.7	-1.2
Delay disc. indifference point, 16s delay	0.6	0.6	2.6	-0.2	1.6	0.6	-0.5	0.2	0.2
Delay disc. indifference point, 2s delay	0.6	0.7	1.6	-1.3	1.2	-0.1	-1.0	-0.2	-0.1
Delay disc. indifference point, 24s delay	0.8	0.8	1.9	-1.0	0.1	-0.5	-1.0	-0.8	1.4
Delay disc. indifference point, 4s delay	1.4	1.4	3.4	-1.8	1.2	-0.7	-1.6	-0.8	0.3
Delay disc. indifference point, 8s delay	1.1	1.1	3.6	-1.2	1.9	0.8	-0.6	0.6	-0.4
Indifference point function ln k	0.5	0.7	1.4	1.1	-1.2	-0.5	-0.1	-0.6	1.0
Indifference point function log k	0.5	0.7	1.4	1.1	-1.2	-0.5	-0.1	-0.6	1.0
Patch foraging total patch changes 0 sec	1.0	1.6	3.3	-1.0	-1.1	-0.9	-1.3	-1.3	1.8
Patch foraging total patch changes 12 sec	2.2	2.9	5.2	-2.3	-0.8	-1.4	-2.0	-1.6	1.7
Patch foraging total patch changes 18 sec	0.3	0.4	2.1	-1.5	0.2	0.1	-0.5	-0.1	0.2
Patch foraging total patch changes 24 sec	2.1	2.6	4.3	-2.1	-0.7	-1.2	-2.0	-1.6	1.7
Patch foraging total patch changes 6 sec	1.9	2.9	3.6	-1.9	-1.3	-1.5	-1.8	-1.7	1.9
Patch foraging time to switch 0 sec	3.3	5.2	7.1	2.4	1.7	2.7	2.5	2.5	-1.7
Patch foraging water rate 0 sec	2.8	4.4	10.2	-3.2	-1.4	-1.8	-2.2	-1.9	1.6
Patch foraging water rate 12 sec	4.2	6.4	9.4	-2.4	-3.1	-2.8	-2.4	-2.5	1.8
Patch foraging water rate 18 sec	2.1	2.8	4.3	-1.1	-2.1	-1.7	-1.6	-1.8	1.7
Patch foraging water rate 24 sec	2.6	3.6	5.9	-0.8	-2.4	-2.4	-1.7	-2.2	1.3
Patch foraging water rate 6 sec	0.6	0.8	2.4	-1.6	-0.3	-1.0	-0.9	-0.7	0.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.1	-0.4	0.0	0.1	0.1	-0.0
Distance traveled before self-admin	0.2	0.3	0.6	0.0	-0.7	-0.6	-0.3	-0.6	0.5
Distance traveled after self-admin	0.3	0.4	1.3	-0.3	-1.1	-0.8	-0.0	-0.4	-0.1
Extensor digitorum longus weight	0.1	0.3	1.4	-0.1	-1.2	-0.5	-0.0	-0.4	0.1
Bone: elastic displacement	0.1	0.1	0.6	0.8	-0.0	0.0	0.2	0.1	-0.1
Bone: elastic work	0.6	0.7	3.0	1.7	-0.4	0.1	0.8	0.3	-0.7
Bone: endosteal estimation	1.7	3.8	4.8	1.4	1.7	2.1	2.1	2.2	-2.0
Bone: endosteal perimeter	1.7	3.6	5.0	0.8	1.7	2.0	2.1	2.2	-2.1
Epididymis fat weight	1.6	3.8	9.0	0.3	-3.0	-1.6	-1.1	-1.9	2.6
Delta time in closed arm before/after self-admin	0.8	0.8	1.9	-0.2	-0.6	-0.7	-0.8	-1.0	1.4
Delta time in open arm before/after self-admin	0.6	0.6	1.2	-1.0	0.7	-0.7	-1.1	-0.5	-0.3
Diff in mean of infusions in LGA sessions	0.3	0.3	0.9	0.9	0.2	0.2	0.8	0.5	-0.5
Delay discount exponential model param	1.2	1.3	3.0	1.7	-1.7	-0.3	1.3	0.1	-0.5
Extinction: sum of active levers before priming	0.7	0.7	1.9	0.1	1.4	0.5	0.4	0.7	-1.1
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.5	-0.5	-0.6	-0.4	-0.5	0.3
Bone: final force	0.1	0.2	0.6	-0.3	0.2	0.4	0.6	0.5	-0.7
Bone: final moment	0.1	0.2	0.5	-0.6	0.2	0.3	0.3	0.4	-0.7
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.2	-0.3	-0.2	-0.2	-0.2	0.5
Glucose	2.2	3.3	5.4	-0.9	-2.3	-1.8	-1.6	-1.9	2.0
Heart weight	1.1	1.6	3.7	0.5	1.4	1.9	1.1	1.5	-0.6
Delay discount hyperbolic model param	1.3	1.4	3.2	1.7	-1.8	-0.2	1.3	0.1	-0.4
Intermittent access intake day 1-15 change	0.2	0.2	0.6	0.5	-0.3	0.4	0.7	0.5	-0.4
Intermittent access intake escalation	1.1	1.1	2.0	1.1	0.2	1.0	1.4	1.1	-1.0
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.3	0.3	0.4	0.2	0.3	-0.2
Intermitt. access day 1 inactive lever presses	0.9	1.0	3.1	1.8	-0.4	0.2	1.1	0.5	-1.0
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.3	0.4	-0.5	-0.2	-0.2	-0.4	0.5
Intermitt. access escalation Index	0.9	0.8	1.8	0.0	-0.8	-1.3	-0.9	-1.2	0.6
Intermittent access day 1 total infusions	0.4	0.5	1.3	0.2	-1.1	-0.6	-0.3	-0.6	1.0
Intermittent access day 15 total infusions	0.5	0.5	1.4	1.2	-0.7	0.4	1.0	0.5	-0.1
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	0.6	-0.7	0.0	0.4	0.0	0.4
Intermittent access total infusions	0.3	0.3	0.7	0.3	-0.8	-0.5	-0.2	-0.4	0.8
Intermittent access day 1 locomotion	0.3	0.3	0.6	0.7	-0.7	-0.6	-0.1	-0.5	0.5
Intermittent access day 15 total locomotion	0.2	0.3	0.3	0.6	0.5	0.5	0.6	0.6	-0.3
Intermittent access total locomotion	0.2	0.2	0.3	0.5	0.5	0.5	0.3	0.4	-0.1
Intermittent access standard deviation	0.6	0.6	1.1	0.7	0.6	1.1	0.8	0.9	-0.4
Left kidney weight	0.6	1.6	3.0	-1.0	-1.1	-1.1	-1.4	-1.3	1.7
Right kidney weight	0.8	2.1	3.3	-1.8	-1.1	-1.0	-1.7	-1.2	1.7
Cocaine induced anxiety	0.3	0.3	0.9	0.9	0.1	0.2	0.6	0.4	-0.7
Post-drug Anxiety	3.3	3.7	5.6	2.4	0.8	2.0	2.4	2.0	-1.5
Baseline Anxiety	2.5	2.7	5.3	1.2	1.0	2.3	1.9	2.0	-0.9
Tail length	1.2	3.5	6.9	-0.4	-2.6	-1.7	-1.2	-1.9	2.5
Length with tail	0.4	1.6	3.3	1.1	-0.7	1.7	1.8	1.3	0.3
Length without tail	4.0	8.8	14.1	2.0	1.6	3.8	3.6	3.6	-2.4
Times rat made contact with spout	0.7	0.8	2.0	-0.1	-1.1	-0.7	-0.7	-0.9	1.4
Lifetime Intake	0.1	0.1	0.2	0.3	-0.4	-0.1	0.1	-0.1	0.4
Liver weight, left	0.5	0.8	1.3	-1.0	-0.3	-1.0	-1.1	-1.0	0.7
Liver weight, right	0.4	0.7	1.5	1.2	-0.5	-0.5	0.9	0.1	-1.1
Locomotor activity	0.4	0.6	1.6	1.3	-1.1	0.0	0.8	0.0	0.1
Locomotor testing distance	0.2	0.3	1.0	0.7	-1.0	0.2	0.7	0.2	0.0
Locomotor testing rearing	0.4	0.6	2.1	-0.3	-1.4	-1.0	-0.2	-0.7	-0.3
Locomotion in novel chamber	1.2	1.5	2.7	-1.7	0.2	-1.2	-1.6	-1.2	0.9
Locomotion in novel chamber post-restriction	0.8	1.0	1.9	-0.9	1.4	0.8	0.4	1.0	-1.1
Fecal boli incidents, locomotor time 1	0.4	0.4	1.5	-1.2	0.5	-0.1	-0.7	-0.1	-0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.2	0.3	0.3	0.3	0.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.4	-0.0	-0.3	-0.3	-0.2	-0.1
Bouts of movement, locomotor time 1	0.9	1.0	1.3	-1.0	-0.6	-1.0	-1.2	-1.0	1.1
Total resting periods, locomotor time 1	0.5	0.5	0.7	-0.8	-0.7	-0.7	-0.7	-0.7	0.8
Rest time, locomotor task time 1	0.7	0.7	2.4	-1.6	0.7	-0.3	-1.0	-0.3	0.4
Distance moved, locomotor task time 1	0.4	0.4	1.1	0.3	-1.1	-0.8	-0.0	-0.7	-0.0
Vertical activity count, locomotor time 1	0.3	0.3	1.2	1.1	-0.7	-0.4	0.3	-0.2	-0.3
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.2	0.5	-0.1	-0.0	0.1	0.0	-0.0
Bouts of movement, locomotor time 2	1.2	1.3	1.8	-1.3	-0.9	-0.9	-1.3	-1.0	1.2
Total resting periods, locomotor time 2	0.9	1.0	1.4	-0.9	-0.8	-0.8	-1.1	-0.9	1.2
Rest time, locomotor task time 2	0.3	0.3	0.5	-0.7	0.7	-0.0	-0.7	-0.1	0.6
Distance moved, locomotor task time 2	0.2	0.2	1.0	0.3	-0.3	-0.2	0.4	0.1	-1.0
Vertical activity count, locomotor time 2	1.3	1.4	3.2	1.0	0.8	0.9	1.2	1.1	-1.8
Light reinforcement 1	0.2	0.4	1.2	-0.4	-1.1	-0.8	-0.4	-0.6	0.1
Light reinforcement 2	0.2	0.3	1.0	0.7	-1.0	-0.4	0.4	-0.1	-0.4
Bone: marrow area	1.9	4.1	5.2	1.3	1.8	2.2	2.2	2.3	-2.1
Bone: maximum diameter	0.7	1.3	1.8	-0.7	1.3	1.1	0.9	1.3	-1.4
Bone: maximum force	0.4	0.8	1.4	0.8	0.2	0.6	1.2	0.8	-1.2
Bone: maximum moment	0.3	0.5	1.2	0.6	0.2	0.5	0.9	0.6	-1.1
Mean time between licks in bursts	1.0	1.4	2.2	1.0	1.4	1.5	1.2	1.3	-0.6
Mean num. licks in bursts	0.5	0.6	1.4	-1.2	0.2	-0.5	-1.0	-0.7	0.7
Cd content in liver	1.0	1.1	2.6	0.4	1.6	0.7	0.6	0.9	-1.5
Co content in liver	0.6	0.7	1.8	0.7	-0.6	-1.4	-0.6	-1.0	0.0
Cu content in liver	0.2	0.2	0.7	-0.4	0.8	0.4	0.1	0.4	-0.5
Fe content in liver	0.4	0.5	0.9	-0.9	-0.1	-0.6	-0.9	-0.7	0.7
K content in liver	1.7	1.6	4.0	2.0	0.2	1.3	1.6	1.1	-0.7
Mg content in liver	0.1	0.1	0.3	0.1	0.2	0.5	0.2	0.3	0.1
Mn content in liver	0.1	0.1	0.2	0.2	-0.4	0.1	-0.1	-0.1	0.5
Na content in liver	0.2	0.2	0.7	-0.5	-0.8	-0.3	-0.3	-0.4	0.2
Rb content in liver	2.4	3.0	4.6	0.9	2.1	2.1	1.5	1.9	-1.6
Se content in liver	1.1	1.3	4.3	-2.1	0.3	-0.2	-1.3	-0.6	1.2
Sr content in liver	0.2	0.2	0.8	0.5	-0.0	-0.1	0.4	0.2	-0.9
Zn content in liver	1.1	1.2	3.5	-1.9	1.4	0.8	-0.3	0.7	-0.6
Bone: minimum diameter	1.5	2.9	4.0	0.5	1.6	1.9	1.9	2.0	-1.9
Time in familiar zone, hab. session 1	4.2	3.9	4.8	-1.4	-1.9	-2.1	-2.2	-2.2	2.0
Time in novel zone, hab. session 1	2.6	2.5	3.0	1.2	1.6	1.6	1.6	1.7	-1.7
Total zone transitions, hab. session 1	0.8	1.2	2.2	-1.0	-1.1	-1.5	-1.1	-1.2	0.0
Total locomotion distance, hab. session 1	1.0	1.3	2.1	-1.2	-1.5	-1.5	-1.0	-1.2	0.2
Locomotion velocity, hab. session 1	0.6	0.9	1.6	-1.0	-1.3	-1.2	-0.6	-0.9	-0.1
Time in familiar zone, hab. session 2	0.3	0.4	1.6	1.3	-0.3	0.2	0.4	0.1	0.4
Time in novel zone, hab. session 2	0.8	0.8	2.5	-1.6	-0.2	-0.7	-1.0	-0.7	0.1
Total zone transitions, hab. session 2	0.2	0.2	0.5	0.5	-0.5	0.1	0.5	0.2	-0.7
Total locomotion distance, hab. session 2	0.2	0.3	1.4	0.0	-1.2	-0.3	0.1	-0.2	-0.1
Locomotion velocity, hab. session 2	0.1	0.2	0.7	0.2	-0.8	0.1	0.4	0.1	-0.3
Novel to familiar place preference ratio	0.0	0.0	0.2	0.2	-0.4	-0.0	0.1	-0.0	0.1
Novelty place preference	0.1	0.1	0.3	0.2	-0.5	-0.1	0.1	-0.1	0.3
Time in novel zone, NPP test	0.2	0.2	0.4	-0.1	-0.6	-0.3	-0.3	-0.4	0.5
Total zone transitions, NPP test	0.5	0.7	1.3	-1.1	-1.0	-0.9	-0.9	-0.8	0.0
Total locomotion distance, NPP test	0.4	0.6	1.3	-0.9	-1.1	-0.8	-0.5	-0.6	-0.2
Locomotion velocity, NPP test	0.2	0.3	1.0	-0.2	-1.0	-0.4	0.1	-0.2	-0.6
Intraocular pressure	0.3	0.5	1.9	1.4	-0.0	-0.0	0.7	0.2	-0.5
Delta distance traveled before/after self-admin	0.2	0.2	0.8	0.1	-0.9	-0.4	0.4	-0.0	-0.2
Delta ambulatory time before/after self-admin	0.4	0.4	0.9	0.6	-0.7	0.0	0.9	0.5	-0.6
Parametrial fat weight	3.4	6.6	11.4	-0.9	-3.4	-2.9	-2.0	-2.8	2.6
Pavlov. Cond. lever latency	0.7	0.9	2.0	1.4	0.6	1.0	1.1	0.9	-0.4
Pavlov. Cond. magazine entry latency	0.3	0.4	1.8	-1.3	-0.2	-0.4	-0.6	-0.3	-0.1
Pavlov. Cond. change in total contacts	0.5	0.6	1.2	-1.1	-0.7	-0.9	-0.8	-0.7	0.1
Pavlov. Cond. index score	0.6	0.7	2.4	-1.5	-0.6	-0.8	-0.9	-0.6	0.1
Pavlov. Cond. latency score	0.5	0.6	2.6	-1.6	-0.2	-0.6	-0.8	-0.5	-0.1
Pavlov. Cond. lever contacts	0.8	1.0	1.4	-1.0	-0.9	-1.2	-1.1	-1.1	0.5
Pavlov. Cond. magazine entry number	0.3	0.4	1.4	1.2	0.5	0.5	0.5	0.3	0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.2	-0.2	-0.4	-0.2	-0.4	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.9	-1.4	-0.6	-0.8	-0.8	-0.6	0.0
Pavlov. Cond. response bias	0.9	1.0	1.3	-1.1	-1.1	-1.1	-1.0	-1.0	0.7
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.0	0.1	-0.2	-0.4	-0.3	0.5
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	-0.5	-0.2	-0.5	-0.3	-0.3	-0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.2	-0.4	-0.3	-0.2	-0.3	0.3
Pavlov. Cond. index score	0.2	0.3	0.4	-0.7	-0.6	-0.6	-0.4	-0.5	0.1
Pavlov. Cond. latency score	0.3	0.3	0.6	-0.6	-0.7	-0.8	-0.5	-0.6	0.2
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.0	-0.3	0.1	0.2	0.1	-0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.5	-0.0	0.2	0.1	0.1	0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	0.6	-0.5	0.6	0.4	0.4	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	-0.5	-0.7	-0.7	-0.5	-0.6	0.3
Pavlov. Cond. response bias	0.2	0.3	0.5	-0.1	0.4	0.7	0.5	0.7	-0.6
Time in closed arm before self-admin	1.0	1.1	1.6	1.1	0.3	1.0	1.2	1.1	-1.3
Time in closed arm after self-admin	0.4	0.5	1.5	0.7	-1.2	-0.6	0.0	-0.6	0.3
Time in open arm before self-admin	0.4	0.4	0.6	-0.6	-0.8	-0.7	-0.4	-0.7	0.6
Time in open arm after self-admin	0.4	0.5	0.9	-0.7	0.4	-1.0	-0.8	-0.7	-0.2
Bone: periosteal estimation	1.2	2.6	4.2	0.2	1.5	1.6	1.7	1.8	-2.1
Bone: periosteal perimeter	1.0	1.7	3.1	0.5	0.7	1.1	1.6	1.5	-1.8
Bone: post-yield work	0.2	0.2	0.9	1.0	-0.3	0.0	0.5	0.1	-0.5
Progressive ratio test 1 active lever presses	0.8	0.8	2.6	1.6	-1.1	-0.2	0.8	0.0	-0.3
Progressive ratio test 1 breakpoint	0.9	0.9	3.2	1.8	-1.0	-0.1	1.0	0.2	-0.4
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.9	0.8	-0.9	-0.3	0.3	-0.2	0.3
Progressive ratio test 2 active lever presses	0.7	0.7	2.9	0.4	-1.7	-0.9	-0.0	-0.6	0.3
Progressive ratio test 2 breakpoint	1.0	1.1	4.0	0.2	-2.0	-1.1	-0.3	-0.9	0.6
Progressive ratio test 2 inactive lever presses	0.7	0.8	0.9	-0.8	-0.9	-0.9	-0.9	-0.9	0.8
Incentive Sensitization - Responses	2.6	2.7	4.4	-1.0	-2.1	-1.8	-1.5	-1.7	1.4
Incentive Sensitization - Breakpoint	2.4	2.4	3.8	-1.1	-1.9	-1.7	-1.5	-1.6	1.3
Sum of active levers in priming session hrs 5-6	1.8	1.8	5.1	-1.2	2.3	1.5	0.3	1.3	-0.5
Progressive ratio	2.1	2.5	4.6	1.1	1.2	2.1	1.7	1.8	-1.2
Food seeking constrained by brief footshock	2.5	3.0	4.5	1.5	0.5	1.8	2.1	1.9	-2.1
Seeking ratio, punishment vs. effort	0.2	0.2	0.4	-0.3	-0.6	-0.7	-0.2	-0.3	-0.3
Retroperitoneal fat weight	1.1	3.5	5.0	-1.2	-2.2	-2.1	-1.6	-2.1	1.8
Reaction time number correct	1.7	2.4	8.9	-3.0	0.3	-0.7	-1.8	-0.9	1.0
Reaction time mean minus median	0.9	1.2	1.5	1.1	0.7	1.2	1.2	1.1	-1.2
Reaction time mean minus median AUC	1.7	2.2	2.8	1.5	1.0	1.6	1.6	1.5	-1.7
Reaction time num false alarms	0.5	0.7	1.4	-1.2	0.1	-0.2	-1.0	-0.5	1.2
Reaction time num false alarms AUC	0.7	0.9	1.7	-1.1	0.0	-0.6	-1.3	-0.8	1.2
Reaction time trials correct on left	1.7	2.4	8.9	-3.0	0.3	-0.7	-1.8	-0.9	1.0
Reaction time trials on left	1.7	2.4	8.9	-3.0	0.2	-0.7	-1.8	-0.9	1.0
Reaction time mean	1.2	1.7	6.6	2.6	-0.4	0.5	1.4	0.6	-0.7
Reaction time mean AUC	1.3	1.7	5.8	2.4	-0.4	0.7	1.5	0.8	-1.0
Median of all reaction times	1.1	1.5	6.5	2.5	-0.9	0.1	1.1	0.2	-0.4
Reaction time omissions	0.3	0.4	1.5	0.2	-1.2	-0.5	-0.2	-0.6	0.4
Reaction time false alarm rate	0.1	0.1	0.2	0.5	0.0	-0.1	-0.2	-0.2	0.5
Reaction time premature initiation rate	0.1	0.1	0.3	0.1	0.1	-0.4	-0.5	-0.5	0.4
Reaction time premature initiations	0.7	0.9	1.8	-1.3	0.1	-0.7	-1.2	-0.9	0.9
Std. dev. reaction times	1.0	1.5	4.5	2.1	0.1	0.8	1.4	0.8	-1.0
Reaction time trials completed	1.7	2.4	8.9	-3.0	0.2	-0.7	-1.8	-0.9	1.0
Reaction time trials AUC	1.7	2.5	9.1	-3.0	0.0	-0.8	-1.8	-1.0	1.1
Run reversals in cocaine runway, females	1.1	1.1	2.4	0.7	0.6	0.8	1.2	1.1	-1.6
Run reversals in cocaine runway, males	0.5	0.5	0.6	-0.7	-0.6	-0.6	-0.8	-0.8	0.7
Latency to leave start box in cocaine runway	1.0	1.1	3.5	1.9	-1.1	-0.5	0.9	-0.0	-1.0
Latency to leave start box in cocaine runway, F	1.0	1.1	2.4	1.5	-0.1	0.3	1.2	0.6	-1.5
Latency to leave start box in cocaine runway, M	1.3	1.3	3.5	0.6	-1.9	-1.5	-0.3	-1.1	0.3
Std. dev. time between licks in bursts	0.8	0.9	2.0	0.4	1.3	0.7	0.6	0.8	-1.4
Total sessions with >9 infusions	0.1	0.1	0.3	-0.1	-0.2	-0.4	-0.4	-0.5	0.5
Short access day 1 total inactive lever presses	0.4	0.5	0.8	-0.7	0.1	-0.9	-0.9	-0.8	0.4
Short access day 10 total inactive lever presses	0.3	0.4	0.7	-0.8	0.2	-0.6	-0.8	-0.6	0.4
Short access day 1 total infusions	0.4	0.4	0.8	-0.5	-0.2	-0.9	-0.8	-0.7	0.2
Short access day 10 total infusions	0.2	0.2	0.6	0.7	-0.4	0.0	0.4	0.0	0.5
Short access total infusions	0.0	0.0	0.1	0.2	-0.0	0.1	0.1	0.0	0.3
Short access day 1 locomotion	0.5	0.6	1.2	0.5	1.1	0.4	0.5	0.6	-1.1
Short access day 10 total locomotion	0.4	0.5	0.9	0.2	0.8	0.9	0.6	0.8	-0.5
Short access total locomotion	0.4	0.4	1.2	-0.0	1.1	0.7	0.4	0.7	-0.6
One hour access (0.3 mA shock)	0.2	0.3	1.2	-1.1	-0.1	-0.3	-0.4	-0.2	-0.1
Compulsive drug intake	0.2	0.2	0.5	0.0	0.6	0.2	0.1	0.4	-0.7
One hour access (shock baseline)	0.5	0.5	2.3	-0.2	-1.5	-0.6	-0.2	-0.5	0.6
Social response proportion	0.2	0.2	0.4	0.4	0.4	0.6	0.5	0.5	-0.3
Social responses	0.3	0.4	0.5	0.6	0.6	0.5	0.6	0.5	-0.7
Social time	1.5	2.0	5.7	-2.4	0.4	-1.2	-1.8	-1.1	0.2
Soleus weight	0.1	0.2	0.4	0.1	-0.5	-0.6	0.0	-0.3	-0.6
Bone: stiffness	0.0	0.0	0.1	-0.1	-0.2	0.1	0.3	0.1	0.1
Tibialis anterior weight	0.3	1.0	1.4	-1.1	-1.1	-1.2	-0.9	-1.0	0.5
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.6	0.4	0.3	-0.1	0.2	-0.2
Time to tail flick, vehicle, after self-admin	1.8	1.9	2.6	0.8	1.6	1.5	1.2	1.5	-1.5
Time to tail flick, test, before self-admin	1.3	1.2	3.7	-1.4	1.9	0.5	-0.4	0.6	-1.1
Time to tail flick, test, after self-admin	0.3	0.3	1.3	-0.4	0.6	-0.3	0.0	0.1	-1.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.2	0.4	1.1	0.7	0.6	0.8	-0.8
Delta time to tail flick, test, before/after SA	1.0	0.9	2.4	0.8	-1.6	-1.2	-0.1	-0.9	0.5
Tibia length	0.6	1.6	4.2	-2.0	-0.6	-1.4	-1.3	-1.1	0.4
Ambulatory time before self-admin	1.2	1.3	1.9	-0.7	-1.0	-1.2	-1.2	-1.4	1.2
Ambulatory time after self-admin	0.6	0.6	2.2	-0.5	-1.5	-0.9	-0.1	-0.7	0.1
Bone: tissue strength	0.6	0.6	1.0	-0.5	-0.3	-0.8	-1.0	-0.9	0.9
Total heroin consumption	0.1	0.1	0.3	0.1	-0.2	-0.2	-0.1	-0.1	0.6
Bone: trabecular number	0.8	1.2	2.9	-0.3	0.8	1.7	1.0	1.5	-0.5
Bone: trabecular spacing	1.9	2.5	3.6	-1.1	-0.6	-1.8	-1.9	-1.9	1.7
Bone: trabecular thickness	3.7	4.4	6.9	0.6	1.8	2.6	2.2	2.6	-2.0
Bone: trabecular tissue density	2.0	2.8	8.6	-2.9	0.3	-1.4	-2.0	-1.3	0.5
Water consumed over 24 hours	1.8	2.2	3.1	-1.6	-1.4	-1.1	-1.5	-1.3	1.8
Number of responses in last shaping day	0.9	1.0	1.8	-0.6	-1.3	-1.3	-0.9	-1.0	0.2