Hub : Genes

Nfkbid

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Nfkbid 0.02 0.01 9.0e-03 0.02 0.01 0.02 0.01 5.5e-03 8.6e-03 3.0e-03 8.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density0.50.90.9-0.9
Area under the delay curve0.40.40.4-0.6
BMI with tail0.10.40.40.6
BMI without tail0.00.10.1-0.3
Body weight3.213.413.4-3.7
Weight adjusted by age0.10.10.1-0.3
Bone surface1.52.72.7-1.6
Bone volume1.42.42.4-1.6
Breakpoint value in progressive ratio session2.83.03.0-1.7
Number of licking bursts4.14.84.82.2
Context. condit. distance diff. score0.00.00.0-0.1
Locomotion velocity, session 10.70.70.70.9
Locomotion distance, session 10.50.60.6-0.8
Locomotion velocity, session 21.01.11.11.1
Locomotion distance, session 21.31.91.91.4
Locomotion velocity, session 30.50.60.60.7
Locomotion distance, session 32.93.23.2-1.8
Stereotopy head waving bouts, day 30.70.80.80.9
Stereotopy head waving duration, day 31.61.91.91.4
Locomotion velocity, session 70.50.50.5-0.7
Locomotion distance, session 70.10.10.1-0.3
Stereotopy head waving bouts, day 71.11.21.21.1
Stereotopy head waving duration, day 72.22.62.61.6
Locomotion velocity, session 83.94.74.72.2
Locomotion distance, session 80.60.90.91.0
Degree of sensitization distance0.70.70.70.8
Degree of sensitization stereotypy1.31.41.41.2
Conditioned locomotion0.40.50.50.7
Cocaine response after cond. corrected0.10.10.10.2
Cocaine response after cond. not corrected0.00.00.00.2
Cocaine response before conditioning0.81.01.0-1.0
Saline control response0.00.00.0-0.0
Bone: connectivity density0.20.30.3-0.5
Bone: cortical apparent density1.52.02.01.4
Bone: cortical area1.32.02.0-1.4
Bone: cortical porosity2.22.42.41.6
Bone: cortical porosity2.93.23.21.8
Bone: cortical thickness0.30.50.5-0.7
Bone: cortical thickness0.70.80.80.9
Bone: cortical tissue density1.82.42.41.6
Condit. Reinf. active minus inactive responses0.20.20.20.4
Condit. Reinf. active-inactive response ratio0.10.10.10.4
Condit. Reinf. active responses1.82.22.21.5
Condit. Reinf. inactive responses1.92.22.21.5
Incentive salience index mean0.20.20.20.4
Condit. Reinf. lever presses0.00.00.0-0.0
Condit. Reinf. active minus inactive responses1.41.71.7-1.3
Condit. Reinf. active-inactive response ratio0.00.10.10.2
Condit. Reinf. active responses3.14.34.3-2.1
Condit. Reinf. inactive responses3.94.84.8-2.2
Condit. Reinf. lever presses7.410.010.0-3.2
Condit. Reinf. lever reinforcers received3.24.54.5-2.1
Conditioned reinforcement - actives0.40.40.40.7
Conditioned reinforcement - inactives0.50.50.5-0.7
Conditioned locomotion2.22.62.61.6
Patch foraging indifference point 0 sec0.00.00.0-0.1
Patch foraging indifference point AUC0.40.40.40.6
Delay disc. indifference point, 0s delay0.40.40.4-0.6
Delay disc. indifference point, 16s delay0.80.80.8-0.9
Delay disc. indifference point, 2s delay1.41.61.6-1.3
Delay disc. indifference point, 24s delay2.82.72.7-1.6
Delay disc. indifference point, 4s delay0.20.20.20.4
Delay disc. indifference point, 8s delay0.10.10.1-0.3
Indifference point function ln k0.50.70.7-0.8
Indifference point function log k0.50.70.7-0.8
Patch foraging total patch changes 0 sec0.00.10.1-0.3
Patch foraging total patch changes 12 sec0.00.00.00.2
Patch foraging total patch changes 18 sec0.10.10.10.3
Patch foraging total patch changes 24 sec0.70.90.9-0.9
Patch foraging total patch changes 6 sec0.00.00.00.1
Patch foraging time to switch 0 sec0.71.11.11.1
Patch foraging water rate 0 sec0.50.80.80.9
Patch foraging water rate 12 sec0.20.30.3-0.6
Patch foraging water rate 18 sec0.20.30.30.5
Patch foraging water rate 24 sec0.00.00.0-0.0
Patch foraging water rate 6 sec0.91.31.3-1.2
Seeking ratio, delayed vs. immediate footshock0.60.70.7-0.8
Distance traveled before self-admin0.00.00.00.1
Distance traveled after self-admin4.14.54.5-2.1
Extensor digitorum longus weight0.00.10.10.3
Bone: elastic displacement0.00.00.00.1
Bone: elastic work1.92.42.4-1.6
Bone: endosteal estimation1.63.43.4-1.9
Bone: endosteal perimeter1.43.03.0-1.7
Epididymis fat weight0.10.30.3-0.5
Delta time in closed arm before/after self-admin3.53.43.4-1.8
Delta time in open arm before/after self-admin1.31.21.21.1
Diff in mean of infusions in LGA sessions0.10.10.10.3
Delay discount exponential model param0.40.50.50.7
Extinction: sum of active levers before priming4.74.74.7-2.2
Active lever presses in extinction session 63.63.53.5-1.9
Bone: final force2.03.23.2-1.8
Bone: final moment2.54.14.1-2.0
Food consumed during 24 hour testing period0.70.80.8-0.9
Glucose0.20.20.20.5
Heart weight0.40.60.6-0.8
Delay discount hyperbolic model param0.40.40.40.6
Intermittent access intake day 1-15 change2.72.72.7-1.6
Intermittent access intake escalation2.82.82.8-1.7
Intermittent access intake escalation 21.61.61.6-1.3
Intermitt. access day 1 inactive lever presses4.64.94.9-2.2
Intermitt. access day 15 inactive lever presses0.50.60.6-0.8
Intermitt. access escalation Index0.00.00.00.2
Intermittent access day 1 total infusions2.93.43.41.8
Intermittent access day 15 total infusions0.10.10.10.2
Intermittent access terminal intake (last 3 days)0.40.50.50.7
Intermittent access total infusions0.80.90.91.0
Intermittent access day 1 locomotion1.11.21.21.1
Intermittent access day 15 total locomotion0.00.00.0-0.1
Intermittent access total locomotion1.31.51.51.2
Intermittent access standard deviation5.35.65.6-2.4
Left kidney weight3.18.78.7-2.9
Right kidney weight5.615.615.6-4.0
Cocaine induced anxiety0.70.80.8-0.9
Post-drug Anxiety0.00.00.00.2
Baseline Anxiety1.92.02.01.4
Tail length4.714.414.4-3.8
Length with tail8.731.831.8-5.6
Length without tail6.313.713.7-3.7
Times rat made contact with spout0.70.80.80.9
Lifetime Intake1.21.31.31.2
Liver weight, left0.40.60.60.8
Liver weight, right0.20.30.30.5
Locomotor activity0.50.80.80.9
Locomotor testing distance0.50.90.91.0
Locomotor testing rearing2.53.93.92.0
Locomotion in novel chamber0.00.00.00.2
Locomotion in novel chamber post-restriction0.00.00.0-0.0
Fecal boli incidents, locomotor time 11.21.31.31.1
Change in fecal boli incidents, locomotor task0.00.00.0-0.1
Time >=10cm from walls, locomotor time 10.10.10.10.3
Bouts of movement, locomotor time 10.80.90.9-0.9
Total resting periods, locomotor time 10.60.70.7-0.8
Rest time, locomotor task time 10.40.40.40.6
Distance moved, locomotor task time 10.00.00.00.0
Vertical activity count, locomotor time 11.51.61.6-1.3
Time >=10cm from walls, locomotor time 21.71.81.81.3
Bouts of movement, locomotor time 20.00.00.00.1
Total resting periods, locomotor time 20.10.10.10.3
Rest time, locomotor task time 20.30.30.30.6
Distance moved, locomotor task time 20.20.20.20.4
Vertical activity count, locomotor time 20.70.80.8-0.9
Light reinforcement 10.20.40.40.7
Light reinforcement 22.02.72.71.6
Bone: marrow area1.63.53.5-1.9
Bone: maximum diameter1.42.52.5-1.6
Bone: maximum force3.15.45.4-2.3
Bone: maximum moment3.76.46.4-2.5
Mean time between licks in bursts0.00.00.00.1
Mean num. licks in bursts1.62.02.0-1.4
Cd content in liver0.00.00.0-0.2
Co content in liver0.20.30.30.5
Cu content in liver0.50.60.6-0.8
Fe content in liver0.00.10.10.2
K content in liver0.00.00.00.1
Mg content in liver0.70.70.70.9
Mn content in liver1.21.31.31.2
Na content in liver0.90.90.9-1.0
Rb content in liver0.00.00.00.0
Se content in liver7.69.39.33.1
Sr content in liver1.11.01.01.0
Zn content in liver0.10.10.10.3
Bone: minimum diameter2.95.45.4-2.3
Time in familiar zone, hab. session 10.70.60.6-0.8
Time in novel zone, hab. session 12.12.02.01.4
Total zone transitions, hab. session 10.00.00.00.0
Total locomotion distance, hab. session 10.60.90.9-1.0
Locomotion velocity, hab. session 10.30.50.5-0.7
Time in familiar zone, hab. session 22.32.42.4-1.6
Time in novel zone, hab. session 21.71.71.71.3
Total zone transitions, hab. session 23.85.05.02.2
Total locomotion distance, hab. session 20.20.30.30.5
Locomotion velocity, hab. session 20.30.40.40.6
Novel to familiar place preference ratio0.10.10.1-0.3
Novelty place preference0.00.00.0-0.2
Time in novel zone, NPP test0.00.00.0-0.0
Total zone transitions, NPP test0.00.10.10.2
Total locomotion distance, NPP test2.02.72.7-1.6
Locomotion velocity, NPP test2.02.82.8-1.7
Intraocular pressure0.00.00.0-0.1
Delta distance traveled before/after self-admin5.66.06.0-2.5
Delta ambulatory time before/after self-admin6.26.86.8-2.6
Parametrial fat weight0.00.00.00.2
Pavlov. Cond. lever latency0.60.70.7-0.9
Pavlov. Cond. magazine entry latency1.31.71.71.3
Pavlov. Cond. change in total contacts0.90.90.91.0
Pavlov. Cond. index score1.51.91.91.4
Pavlov. Cond. latency score0.91.21.21.1
Pavlov. Cond. lever contacts0.10.10.10.3
Pavlov. Cond. magazine entry number1.62.02.0-1.4
Pavlov. Cond. intertrial magazine entries0.30.40.40.6
Pavlov. Cond. lever-magazine prob. diff.1.92.42.41.5
Pavlov. Cond. response bias0.70.90.91.0
Pavlov. Cond. lever latency4.96.66.62.6
Pavlov. Cond. magazine entry latency2.73.13.1-1.8
Pavlov. Cond. change in total contacts8.111.111.1-3.3
Pavlov. Cond. index score4.76.06.0-2.4
Pavlov. Cond. latency score4.45.55.5-2.4
Pavlov. Cond. lever contacts4.25.85.8-2.4
Pavlov. Cond. magazine entry number3.64.44.42.1
Pavlov. Cond. intertrial magazine entries1.01.31.31.1
Pavlov. Cond. lever-magazine prob. diff.4.55.75.7-2.4
Pavlov. Cond. response bias4.76.46.4-2.5
Time in closed arm before self-admin3.43.93.92.0
Time in closed arm after self-admin0.10.10.1-0.2
Time in open arm before self-admin4.14.54.5-2.1
Time in open arm after self-admin0.60.70.7-0.8
Bone: periosteal estimation2.04.24.2-2.0
Bone: periosteal perimeter1.32.12.1-1.4
Bone: post-yield work1.92.62.6-1.6
Progressive ratio test 1 active lever presses0.30.30.3-0.5
Progressive ratio test 1 breakpoint0.60.70.7-0.8
Progressive ratio test 1 inactive lever presses0.60.70.7-0.8
Progressive ratio test 2 active lever presses0.00.00.00.2
Progressive ratio test 2 breakpoint0.10.10.10.3
Progressive ratio test 2 inactive lever presses0.91.01.0-1.0
Incentive Sensitization - Responses0.10.10.10.3
Incentive Sensitization - Breakpoint0.10.10.10.3
Sum of active levers in priming session hrs 5-60.30.30.3-0.5
Progressive ratio0.00.00.00.2
Food seeking constrained by brief footshock2.93.63.6-1.9
Seeking ratio, punishment vs. effort0.60.80.8-0.9
Retroperitoneal fat weight1.13.63.61.9
Reaction time number correct0.00.00.0-0.2
Reaction time mean minus median0.30.40.4-0.6
Reaction time mean minus median AUC0.70.90.9-0.9
Reaction time num false alarms1.01.31.31.1
Reaction time num false alarms AUC1.11.51.51.2
Reaction time trials correct on left0.00.00.0-0.2
Reaction time trials on left0.00.00.0-0.2
Reaction time mean0.00.10.1-0.2
Reaction time mean AUC0.00.00.0-0.0
Median of all reaction times0.00.00.00.1
Reaction time omissions0.10.10.10.3
Reaction time false alarm rate0.81.21.21.1
Reaction time premature initiation rate0.00.00.0-0.1
Reaction time premature initiations0.00.00.0-0.2
Std. dev. reaction times0.40.60.6-0.8
Reaction time trials completed0.00.00.0-0.2
Reaction time trials AUC0.00.00.0-0.1
Run reversals in cocaine runway, females0.70.70.7-0.8
Run reversals in cocaine runway, males0.20.20.20.4
Latency to leave start box in cocaine runway0.30.30.3-0.5
Latency to leave start box in cocaine runway, F0.10.10.1-0.3
Latency to leave start box in cocaine runway, M0.00.00.0-0.1
Std. dev. time between licks in bursts0.00.00.0-0.2
Total sessions with >9 infusions2.02.22.21.5
Short access day 1 total inactive lever presses0.30.30.3-0.6
Short access day 10 total inactive lever presses2.62.92.9-1.7
Short access day 1 total infusions0.40.40.40.7
Short access day 10 total infusions0.70.80.80.9
Short access total infusions1.71.91.91.4
Short access day 1 locomotion0.40.50.50.7
Short access day 10 total locomotion0.30.40.4-0.6
Short access total locomotion1.41.41.41.2
One hour access (0.3 mA shock)0.30.40.4-0.6
Compulsive drug intake0.00.00.0-0.1
One hour access (shock baseline)0.00.00.00.2
Social response proportion3.33.53.5-1.9
Social responses1.01.31.3-1.1
Social time3.14.14.1-2.0
Soleus weight0.10.20.20.4
Bone: stiffness1.93.03.0-1.7
Tibialis anterior weight0.00.00.0-0.0
Time to tail flick, vehicle, before self-admin0.91.01.01.0
Time to tail flick, vehicle, after self-admin0.00.00.00.1
Time to tail flick, test, before self-admin0.40.40.40.6
Time to tail flick, test, after self-admin0.00.00.0-0.0
Delta time to tail flick, vehicle, before/after SA0.50.50.5-0.7
Delta time to tail flick, test, before/after SA0.10.10.10.2
Tibia length3.39.39.3-3.0
Ambulatory time before self-admin0.00.00.00.2
Ambulatory time after self-admin9.110.010.0-3.2
Bone: tissue strength4.34.24.2-2.0
Total heroin consumption0.50.60.6-0.8
Bone: trabecular number1.62.42.4-1.6
Bone: trabecular spacing0.00.00.0-0.2
Bone: trabecular thickness0.00.00.00.2
Bone: trabecular tissue density2.33.33.31.8
Water consumed over 24 hours0.40.50.5-0.7
Number of responses in last shaping day0.10.10.10.3