Hub : Genes

Nf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Nf1	0.05	0.04	5.5e-09	0.04	0.06	0.05	0.05	2.0e-07	9.1e-09	1.6e-08	1.3e-08
2	Brain	gene expression	Nf1	0.04	0.03	2.2e-04	0.03	0.04	0.03	0.03	4.8e-04	2.4e-04	8.3e-04	6.9e-04
3	PL	gene expression	Nf1	0.11	0.08	7.9e-04	0.01	0.01	0.01	0.01	2.3e-02	1.1e-02	5.8e-02	6.9e-02
4	Liver	gene expression	Nf1	0.03	0.04	7.4e-03	0.01	0.01	0.01	0.01	1.1e-02	1.3e-02	3.4e-02	1.3e-02
5	Adipose	gene expression	Nf1	0.19	0.12	0.0e+00	0.16	0.16	0.16	0.16	6.9e-18	8.3e-18	9.1e-18	7.6e-18
6	Adipose	intron excision ratio	chr10_64902866_64903301	0.02	0.02	8.2e-03	0.01	0.01	0.01	0.01	5.2e-02	1.3e-02	8.4e-03	3.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	2.8	4.8	5.4	2.3	2.2	2.1	-2.3	-2.3	-1.9
Area under the delay curve	0.3	0.4	0.6	-0.6	-0.7	-0.2	0.6	0.6	0.8
BMI with tail	0.7	2.3	3.9	1.5	2.0	0.1	-1.6	-1.6	-1.7
BMI without tail	0.7	2.2	4.5	1.3	1.7	0.3	-1.5	-1.4	-2.1
Body weight	2.7	11.9	13.7	3.6	3.7	2.9	-3.7	-3.6	-3.2
Weight adjusted by age	1.1	1.7	4.2	-1.3	-0.9	-2.1	1.2	1.2	-0.8
Bone surface	0.7	1.3	2.1	1.2	1.4	0.4	-1.2	-1.2	-1.2
Bone volume	1.0	1.8	2.4	1.4	1.5	1.0	-1.4	-1.4	-1.2
Breakpoint value in progressive ratio session	2.1	2.6	5.2	1.7	1.3	2.3	-1.5	-1.6	-0.9
Number of licking bursts	0.7	1.1	1.9	-1.0	-0.9	-1.0	1.0	1.0	1.4
Context. condit. distance diff. score	0.5	0.6	0.7	0.8	0.8	0.5	-0.8	-0.8	-0.8
Locomotion velocity, session 1	2.2	2.3	3.2	1.7	1.7	1.3	-1.4	-1.8	-1.2
Locomotion distance, session 1	0.0	0.1	0.1	0.2	0.4	-0.3	-0.1	-0.3	-0.1
Locomotion velocity, session 2	0.1	0.1	0.1	0.2	0.2	0.2	0.0	-0.4	-0.3
Locomotion distance, session 2	0.5	0.7	1.4	0.7	1.0	0.0	-0.6	-0.8	-1.2
Locomotion velocity, session 3	3.1	3.5	4.6	-1.8	-1.8	-1.6	2.0	1.7	2.1
Locomotion distance, session 3	0.7	0.8	1.4	-0.8	-0.8	-0.9	0.9	0.7	1.2
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	0.1	0.1	-0.0	0.0	0.1	-0.3
Stereotopy head waving duration, day 3	0.3	0.4	0.7	-0.5	-0.6	-0.2	0.7	0.6	0.8
Locomotion velocity, session 7	0.1	0.1	0.2	-0.1	-0.0	-0.4	0.3	0.0	-0.4
Locomotion distance, session 7	0.0	0.1	0.2	-0.0	0.1	-0.4	-0.1	-0.1	-0.4
Stereotopy head waving bouts, day 7	0.9	1.0	1.4	1.1	1.0	1.2	-1.0	-1.0	-0.6
Stereotopy head waving duration, day 7	0.5	0.6	1.1	0.9	0.7	1.0	-0.8	-0.8	-0.3
Locomotion velocity, session 8	0.1	0.1	0.2	0.3	0.4	0.1	-0.1	-0.5	-0.2
Locomotion distance, session 8	0.4	0.6	1.3	0.6	0.8	-0.0	-0.6	-0.8	-1.2
Degree of sensitization distance	2.4	2.4	4.6	1.4	1.5	1.1	-1.6	-1.4	-2.1
Degree of sensitization stereotypy	1.1	1.2	1.7	1.2	1.1	1.3	-1.1	-1.1	-0.6
Conditioned locomotion	2.8	3.2	4.7	-1.9	-1.7	-2.2	1.8	1.9	1.2
Cocaine response after cond. corrected	0.7	0.9	1.7	0.9	1.1	0.2	-0.9	-0.9	-1.3
Cocaine response after cond. not corrected	1.4	1.6	2.2	1.3	1.5	0.7	-1.3	-1.3	-1.5
Cocaine response before conditioning	0.3	0.3	0.5	0.6	0.6	0.7	-0.6	-0.6	-0.2
Saline control response	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.4	0.2	0.2
Bone: connectivity density	3.0	4.7	6.0	2.3	2.4	1.6	-2.3	-2.3	-2.0
Bone: cortical apparent density	0.3	0.4	0.6	-0.6	-0.7	-0.2	0.5	0.6	0.8
Bone: cortical area	2.3	3.5	4.4	-1.9	-1.7	-2.1	1.9	1.8	1.8
Bone: cortical porosity	0.1	0.1	0.4	-0.3	-0.2	-0.7	0.3	0.3	-0.2
Bone: cortical porosity	0.2	0.3	0.7	-0.5	-0.4	-0.8	0.5	0.5	-0.1
Bone: cortical thickness	3.0	5.1	5.6	-2.3	-2.3	-1.9	2.4	2.3	2.3
Bone: cortical thickness	0.5	0.6	0.9	-0.7	-0.6	-0.9	0.8	0.7	1.0
Bone: cortical tissue density	0.1	0.2	0.3	-0.4	-0.5	-0.1	0.3	0.4	0.5
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	-0.9	-0.9	-0.6	0.6	0.9	0.5
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.6	-0.7	-0.7	-0.8	0.6	0.7	0.7
Condit. Reinf. active responses	0.1	0.1	0.2	-0.2	-0.2	-0.3	-0.1	0.2	-0.4
Condit. Reinf. inactive responses	0.3	0.4	1.4	0.4	0.5	-0.0	-0.5	-0.3	-1.2
Incentive salience index mean	0.3	0.4	0.6	-0.7	-0.6	-0.8	0.5	0.7	0.2
Condit. Reinf. lever presses	0.2	0.2	0.8	0.3	0.4	0.0	-0.4	-0.3	-0.9
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.5	-0.7	-0.0	0.5	0.4	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.6	0.0	-0.3	0.8	0.1	-0.1	0.5
Condit. Reinf. active responses	0.2	0.3	0.5	-0.7	-0.7	-0.4	0.6	0.6	0.5
Condit. Reinf. inactive responses	0.5	0.6	1.5	-0.8	-0.6	-1.2	0.6	0.8	0.1
Condit. Reinf. lever presses	1.3	1.7	2.6	-1.3	-1.5	-0.7	1.2	1.3	1.6
Condit. Reinf. lever reinforcers received	0.4	0.6	0.8	-0.9	-0.9	-0.6	0.8	0.8	0.7
Conditioned reinforcement - actives	0.2	0.4	1.1	0.5	0.6	0.3	-0.5	-0.4	-1.1
Conditioned reinforcement - inactives	0.1	0.1	0.4	-0.1	0.1	-0.7	0.1	0.2	-0.4
Conditioned locomotion	0.1	0.2	0.6	0.2	0.5	-0.4	-0.1	-0.1	-0.8
Patch foraging indifference point 0 sec	0.3	0.6	0.7	-0.8	-0.8	-0.6	0.7	0.8	0.8
Patch foraging indifference point AUC	1.5	2.1	2.8	-1.6	-1.6	-1.4	1.7	1.5	1.0
Delay disc. indifference point, 0s delay	0.9	0.9	1.1	-1.0	-1.0	-0.8	1.0	1.0	0.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	0.1	-0.1	0.6	-0.1	-0.0	0.3
Delay disc. indifference point, 2s delay	1.0	1.2	1.8	-1.0	-1.3	-0.4	1.1	1.1	1.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.9	-0.1	0.2	-1.0	0.1	0.1	-0.6
Delay disc. indifference point, 4s delay	0.4	0.4	1.5	0.6	0.3	1.2	-0.5	-0.5	0.0
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.1	-0.2	0.2	0.1	0.0	0.3
Indifference point function ln k	1.3	2.2	4.4	1.6	1.3	2.1	-1.6	-1.5	-0.4
Indifference point function log k	1.3	2.2	4.4	1.6	1.3	2.1	-1.6	-1.5	-0.4
Patch foraging total patch changes 0 sec	0.3	0.5	0.7	-0.7	-0.8	-0.6	0.7	0.8	0.8
Patch foraging total patch changes 12 sec	0.2	0.3	0.5	-0.5	-0.4	-0.7	0.5	0.5	-0.4
Patch foraging total patch changes 18 sec	0.9	1.3	1.9	-1.2	-1.4	-0.8	1.2	1.2	1.0
Patch foraging total patch changes 24 sec	0.8	1.5	2.1	-1.3	-1.5	-0.8	1.3	1.3	0.9
Patch foraging total patch changes 6 sec	2.7	4.1	4.8	-2.2	-2.2	-1.9	2.2	2.1	1.6
Patch foraging time to switch 0 sec	1.1	2.2	3.3	1.4	1.6	0.9	-1.6	-1.4	-1.8
Patch foraging water rate 0 sec	1.5	3.1	4.8	-1.7	-1.8	-1.3	1.8	1.7	2.2
Patch foraging water rate 12 sec	0.1	0.1	0.2	0.3	0.2	0.5	-0.4	-0.4	0.2
Patch foraging water rate 18 sec	0.7	1.1	2.0	1.1	0.8	1.4	-1.0	-1.1	-0.6
Patch foraging water rate 24 sec	0.2	0.3	0.3	-0.5	-0.5	-0.5	0.5	0.5	0.6
Patch foraging water rate 6 sec	0.8	1.1	3.3	-0.9	-1.1	-0.1	1.0	0.8	1.8
Seeking ratio, delayed vs. immediate footshock	1.7	2.0	2.5	-1.6	-1.6	-1.4	1.6	1.6	0.6
Distance traveled before self-admin	1.9	2.5	3.4	-1.6	-1.8	-1.0	1.8	1.7	1.3
Distance traveled after self-admin	0.0	0.1	0.2	-0.2	-0.2	-0.1	0.5	0.2	0.2
Extensor digitorum longus weight	0.2	0.9	1.7	0.8	1.2	-0.2	-0.8	-0.9	-1.3
Bone: elastic displacement	2.0	2.3	3.0	-1.6	-1.7	-1.2	1.6	1.6	1.5
Bone: elastic work	7.3	9.5	11.1	-3.2	-3.3	-2.7	3.2	3.2	2.8
Bone: endosteal estimation	0.0	0.1	0.3	-0.2	-0.1	-0.6	0.2	0.2	0.3
Bone: endosteal perimeter	0.1	0.2	0.3	0.5	0.5	0.3	-0.5	-0.5	-0.1
Epididymis fat weight	8.1	27.8	30.4	5.5	5.5	4.7	-5.4	-5.5	-5.0
Delta time in closed arm before/after self-admin	1.1	1.0	2.1	-0.9	-1.2	-0.1	1.0	0.9	1.4
Delta time in open arm before/after self-admin	3.8	3.8	5.1	1.9	2.3	0.9	-2.2	-2.0	-2.2
Diff in mean of infusions in LGA sessions	1.7	2.1	3.1	1.6	1.4	1.7	-1.4	-1.5	-0.8
Delay discount exponential model param	0.2	0.2	0.3	0.4	0.5	0.1	-0.5	-0.4	-0.6
Extinction: sum of active levers before priming	0.7	0.8	1.1	1.0	1.0	0.9	-0.8	-1.0	-0.3
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	0.3	0.4	-0.1	-0.3	0.0
Bone: final force	0.8	1.3	2.2	-1.2	-1.0	-1.5	1.2	1.1	0.7
Bone: final moment	0.7	1.1	1.8	-1.1	-0.9	-1.3	1.1	1.1	0.6
Food consumed during 24 hour testing period	0.3	0.3	0.6	-0.5	-0.7	-0.1	0.6	0.5	0.8
Glucose	1.2	1.9	2.4	-1.5	-1.5	-1.2	1.4	1.5	1.1
Heart weight	0.9	1.4	4.2	0.9	1.1	0.3	-1.1	-0.7	-2.1
Delay discount hyperbolic model param	0.4	0.4	0.7	0.6	0.8	0.2	-0.7	-0.6	-0.8
Intermittent access intake day 1-15 change	0.5	1.0	2.2	-1.0	-0.8	-1.5	0.9	1.0	0.2
Intermittent access intake escalation	0.4	0.8	2.3	-0.9	-0.6	-1.5	0.8	0.9	-0.0
Intermittent access intake escalation 2	1.3	1.4	2.6	-1.2	-1.0	-1.6	1.3	1.2	0.6
Intermitt. access day 1 inactive lever presses	0.3	1.1	2.2	-1.1	-0.9	-1.5	1.0	1.0	0.7
Intermitt. access day 15 inactive lever presses	0.7	1.5	1.9	-1.3	-1.2	-1.4	1.3	1.3	0.7
Intermitt. access escalation Index	2.9	4.2	5.9	2.0	1.8	2.4	-2.1	-2.0	-1.9
Intermittent access day 1 total infusions	0.3	0.5	1.1	0.6	0.8	0.2	-0.6	-0.6	-1.0
Intermittent access day 15 total infusions	0.2	0.4	1.1	0.1	0.6	-0.8	-0.2	-0.1	-1.0
Intermittent access terminal intake (last 3 days)	0.6	0.8	1.5	0.8	1.1	0.2	-0.9	-0.8	-1.2
Intermittent access total infusions	0.1	0.2	0.4	0.1	0.4	-0.6	-0.2	-0.1	-0.6
Intermittent access day 1 locomotion	0.1	0.1	0.7	-0.2	0.1	-0.8	0.2	0.2	-0.2
Intermittent access day 15 total locomotion	0.4	0.7	2.8	-0.6	-0.1	-1.7	0.5	0.6	-0.3
Intermittent access total locomotion	0.5	0.7	2.9	-0.5	0.0	-1.7	0.5	0.5	-0.6
Intermittent access standard deviation	0.4	0.9	2.3	-0.9	-0.6	-1.5	0.9	0.9	0.2
Left kidney weight	0.2	0.8	1.0	0.8	0.8	0.9	-1.0	-0.8	-0.9
Right kidney weight	0.3	1.2	2.0	1.0	1.1	0.8	-1.3	-1.0	-1.4
Cocaine induced anxiety	0.3	0.4	1.2	0.5	0.3	1.1	-0.5	-0.5	0.3
Post-drug Anxiety	2.4	2.5	6.0	1.6	1.2	2.5	-1.6	-1.5	-0.5
Baseline Anxiety	0.2	0.2	0.4	0.5	0.4	0.6	-0.5	-0.4	-0.4
Tail length	0.6	2.4	3.5	1.5	1.3	1.7	-1.5	-1.5	-1.9
Length with tail	1.6	7.2	11.0	2.8	2.4	3.3	-2.7	-2.8	-2.0
Length without tail	1.2	3.9	5.4	2.1	1.9	2.3	-2.1	-2.1	-0.9
Times rat made contact with spout	0.1	0.2	0.8	-0.1	-0.3	0.2	0.2	0.1	0.9
Lifetime Intake	0.3	0.4	0.7	0.5	0.8	-0.1	-0.6	-0.5	-0.8
Liver weight, left	6.6	10.9	12.4	3.5	3.4	3.3	-3.4	-3.5	-2.6
Liver weight, right	6.4	11.1	12.3	3.5	3.3	3.4	-3.5	-3.5	-2.7
Locomotor activity	0.1	0.1	0.4	0.3	0.1	0.6	-0.3	-0.3	0.4
Locomotor testing distance	0.1	0.1	0.4	0.0	-0.1	0.4	-0.1	-0.1	0.7
Locomotor testing rearing	0.1	0.1	0.5	-0.3	-0.4	0.0	0.2	0.2	0.7
Locomotion in novel chamber	1.9	2.4	2.9	-1.7	-1.7	-1.5	1.7	1.7	0.9
Locomotion in novel chamber post-restriction	0.4	0.7	1.4	0.8	0.6	1.2	-0.8	-0.7	-0.7
Fecal boli incidents, locomotor time 1	0.2	0.3	0.8	0.3	0.6	-0.5	-0.4	-0.4	-0.9
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.2	0.2	0.1
Time >=10cm from walls, locomotor time 1	0.7	0.8	2.1	-0.9	-0.6	-1.5	0.8	0.8	0.2
Bouts of movement, locomotor time 1	1.4	1.5	2.3	-1.3	-1.1	-1.5	1.3	1.3	0.9
Total resting periods, locomotor time 1	1.4	1.5	3.0	-1.3	-1.1	-1.7	1.2	1.2	0.7
Rest time, locomotor task time 1	0.7	0.9	2.6	-0.9	-0.6	-1.6	0.9	0.9	0.2
Distance moved, locomotor task time 1	0.3	0.5	1.8	0.6	0.3	1.3	-0.5	-0.5	0.1
Vertical activity count, locomotor time 1	0.5	1.2	3.0	1.1	0.8	1.7	-1.0	-1.1	-0.4
Time >=10cm from walls, locomotor time 2	0.6	1.0	4.1	-0.8	-0.2	-2.0	0.6	0.6	-0.4
Bouts of movement, locomotor time 2	0.1	0.2	0.4	-0.3	-0.5	0.2	0.3	0.3	0.6
Total resting periods, locomotor time 2	0.1	0.2	0.2	-0.4	-0.5	-0.2	0.4	0.4	0.5
Rest time, locomotor task time 2	0.8	1.1	1.9	-1.1	-0.9	-1.4	1.0	1.0	0.6
Distance moved, locomotor task time 2	0.8	0.9	2.6	1.0	0.6	1.6	-0.9	-0.9	-0.2
Vertical activity count, locomotor time 2	1.6	2.2	5.2	1.5	1.1	2.3	-1.4	-1.5	-0.6
Light reinforcement 1	0.2	0.6	1.4	0.8	0.5	1.2	-0.6	-0.8	-0.4
Light reinforcement 2	0.2	0.3	1.3	0.4	0.1	1.1	-0.3	-0.4	0.3
Bone: marrow area	0.1	0.1	0.4	-0.3	-0.1	-0.7	0.3	0.3	0.3
Bone: maximum diameter	0.8	1.5	2.4	-1.2	-0.9	-1.5	1.2	1.2	1.2
Bone: maximum force	1.5	2.6	4.0	-1.6	-1.4	-2.0	1.7	1.6	1.2
Bone: maximum moment	1.4	2.4	3.4	-1.6	-1.4	-1.8	1.7	1.5	1.2
Mean time between licks in bursts	0.1	0.2	0.3	0.3	0.6	-0.4	-0.4	-0.3	0.2
Mean num. licks in bursts	0.5	0.8	1.0	0.8	0.7	1.0	-0.9	-0.9	-0.9
Cd content in liver	0.1	0.1	0.3	-0.2	-0.3	0.1	0.3	0.3	0.5
Co content in liver	0.7	0.8	1.1	-0.9	-0.9	-0.9	0.9	1.0	0.8
Cu content in liver	1.7	2.0	2.2	-1.4	-1.5	-1.1	1.5	1.5	1.4
Fe content in liver	2.7	3.3	3.8	1.9	1.9	1.5	-1.8	-1.9	-1.8
K content in liver	0.2	0.2	0.2	0.4	0.4	0.4	-0.4	-0.4	-0.4
Mg content in liver	0.3	0.3	0.5	-0.5	-0.6	-0.3	0.6	0.6	0.7
Mn content in liver	0.4	0.4	0.6	-0.7	-0.7	-0.6	0.7	0.7	0.6
Na content in liver	1.5	1.6	2.5	1.3	1.1	1.6	-1.1	-1.4	-0.8
Rb content in liver	0.1	0.1	0.3	-0.2	-0.0	-0.5	0.1	0.3	-0.2
Se content in liver	0.7	0.9	1.1	-0.9	-0.9	-0.9	1.1	0.9	1.0
Sr content in liver	0.1	0.1	0.3	0.3	0.2	0.5	-0.2	-0.3	-0.2
Zn content in liver	0.5	0.5	0.6	0.8	0.8	0.6	-0.7	-0.7	-0.8
Bone: minimum diameter	0.0	0.0	0.1	-0.2	-0.1	-0.3	0.1	0.1	0.3
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.3	-0.5	0.0	0.1	0.4	-0.2
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.4	0.4	0.3	-0.1	-0.4	-0.0
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.0	0.0	-0.1	0.0	-0.1	0.1
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.0	-0.2	0.3	0.0	-0.0	0.2
Locomotion velocity, hab. session 1	0.2	0.3	0.6	-0.5	-0.6	-0.4	0.5	0.5	0.7
Time in familiar zone, hab. session 2	0.0	0.0	0.2	0.0	-0.2	0.5	-0.2	-0.0	0.1
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.4	-0.3	-0.6	0.6	0.4	0.4
Total zone transitions, hab. session 2	0.3	0.4	1.3	0.5	0.6	0.3	-0.5	-0.7	-1.1
Total locomotion distance, hab. session 2	0.1	0.2	0.2	-0.5	-0.4	-0.5	0.4	0.3	-0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.4	0.3	0.0
Novel to familiar place preference ratio	0.4	0.4	1.7	0.4	0.6	-0.1	-0.6	-0.3	-1.3
Novelty place preference	0.7	0.8	2.3	0.7	0.8	0.3	-0.8	-0.6	-1.5
Time in novel zone, NPP test	0.8	0.8	2.4	0.8	0.9	0.3	-0.9	-0.7	-1.5
Total zone transitions, NPP test	0.0	0.0	0.0	0.1	0.2	-0.2	-0.0	-0.2	-0.2
Total locomotion distance, NPP test	0.9	1.2	1.3	-1.1	-1.1	-1.1	1.1	1.1	1.1
Locomotion velocity, NPP test	1.1	1.6	1.7	-1.3	-1.3	-1.2	1.2	1.2	1.3
Intraocular pressure	2.4	3.4	4.6	-1.9	-1.9	-2.0	2.1	1.9	1.2
Delta distance traveled before/after self-admin	1.5	1.6	2.2	1.3	1.5	0.6	-1.3	-1.3	-1.4
Delta ambulatory time before/after self-admin	1.5	1.8	2.6	1.5	1.6	1.1	-1.5	-1.5	-0.5
Parametrial fat weight	6.9	16.3	18.2	4.3	4.2	3.9	-4.2	-4.2	-3.5
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.3	0.2	0.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.7	0.7	0.7	-0.8	-0.7	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.2	0.0	-0.1	0.4	-0.1	-0.1	-0.1
Pavlov. Cond. index score	0.2	0.2	0.3	0.5	0.4	0.6	-0.6	-0.4	-0.1
Pavlov. Cond. latency score	0.2	0.3	0.4	0.5	0.5	0.6	-0.6	-0.6	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	0.4	0.4	-0.5	-0.4	0.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.3	-0.2	-0.6	0.5	0.3	0.0
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.3	-1.0	-0.8	-1.1	0.9	1.0	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.3	0.3	0.4	-0.5	-0.3	-0.1
Pavlov. Cond. response bias	0.2	0.3	0.5	0.6	0.5	0.6	-0.7	-0.5	-0.3
Pavlov. Cond. lever latency	1.2	1.6	2.4	1.4	1.5	0.8	-1.2	-1.4	-1.3
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.1	-0.1	0.4	-0.1	-0.0	0.2
Pavlov. Cond. change in total contacts	0.7	1.2	1.6	-1.2	-1.3	-0.8	1.1	1.1	1.1
Pavlov. Cond. index score	1.1	1.4	2.0	-1.2	-1.4	-0.7	1.1	1.2	1.3
Pavlov. Cond. latency score	1.4	1.8	2.4	-1.4	-1.6	-0.8	1.2	1.4	1.5
Pavlov. Cond. lever contacts	0.7	0.9	1.4	-1.0	-1.2	-0.6	0.9	1.0	1.0
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	0.1	0.1	-0.0	-0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.3	0.5	-0.0	-0.3	-0.4	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	1.4	-1.0	-1.2	-0.5	0.9	1.0	1.2
Pavlov. Cond. response bias	0.3	0.4	0.7	-0.7	-0.8	-0.2	0.4	0.7	0.6
Time in closed arm before self-admin	2.0	2.6	3.5	1.6	1.7	1.4	-1.5	-1.6	-1.9
Time in closed arm after self-admin	0.1	0.1	0.2	-0.2	-0.3	0.1	0.4	0.2	0.5
Time in open arm before self-admin	3.9	4.3	4.9	-2.2	-2.2	-2.0	2.1	2.2	1.7
Time in open arm after self-admin	0.1	0.1	0.5	0.0	0.4	-0.7	-0.2	-0.1	-0.5
Bone: periosteal estimation	0.7	1.6	2.5	-1.2	-1.0	-1.6	1.2	1.2	1.2
Bone: periosteal perimeter	0.2	0.3	0.5	-0.5	-0.4	-0.7	0.5	0.5	0.7
Bone: post-yield work	0.1	0.1	0.2	0.3	0.5	-0.1	-0.3	-0.3	-0.3
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	-0.3	-0.4	0.0	0.3	0.3	0.6
Progressive ratio test 1 breakpoint	0.1	0.1	0.4	-0.3	-0.4	0.0	0.3	0.4	0.7
Progressive ratio test 1 inactive lever presses	2.0	2.8	3.8	-1.6	-1.5	-1.7	1.6	1.6	2.0
Progressive ratio test 2 active lever presses	0.9	1.1	1.9	-1.1	-0.9	-1.4	1.0	1.1	0.4
Progressive ratio test 2 breakpoint	0.9	1.0	1.9	-1.1	-0.9	-1.4	1.0	1.1	0.4
Progressive ratio test 2 inactive lever presses	0.8	1.2	2.7	-1.2	-0.9	-1.6	1.1	1.2	0.4
Incentive Sensitization - Responses	0.3	0.5	1.5	-0.6	-0.4	-1.2	0.5	0.6	-0.3
Incentive Sensitization - Breakpoint	0.3	0.4	1.4	-0.6	-0.3	-1.2	0.4	0.6	-0.4
Sum of active levers in priming session hrs 5-6	2.1	1.9	2.3	1.5	1.5	1.5	-1.3	-1.5	-1.0
Progressive ratio	1.0	1.6	3.7	-1.3	-1.0	-1.9	1.1	1.2	0.6
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.2	0.2	0.0	-0.0	-0.3	-0.0
Seeking ratio, punishment vs. effort	0.6	0.8	2.1	1.0	0.7	1.4	-0.7	-0.9	-0.4
Retroperitoneal fat weight	1.7	7.4	11.2	2.9	2.6	3.4	-2.8	-2.8	-1.7
Reaction time number correct	0.1	0.3	1.4	-0.3	0.1	-1.2	0.3	0.2	-0.0
Reaction time mean minus median	0.3	0.7	0.9	0.9	0.8	1.0	-0.8	-0.8	-0.7
Reaction time mean minus median AUC	1.1	2.7	3.0	1.7	1.7	1.5	-1.7	-1.7	-1.6
Reaction time num false alarms	3.6	5.1	7.8	-2.2	-2.5	-1.1	2.3	2.3	2.8
Reaction time num false alarms AUC	4.0	6.3	8.5	-2.5	-2.7	-1.6	2.5	2.6	2.9
Reaction time trials correct on left	0.1	0.3	1.4	-0.3	0.1	-1.2	0.3	0.2	-0.0
Reaction time trials on left	0.2	0.3	1.5	-0.3	0.1	-1.2	0.3	0.2	-0.0
Reaction time mean	1.0	1.6	1.8	1.3	1.2	1.3	-1.3	-1.3	-1.0
Reaction time mean AUC	0.8	1.2	1.4	1.2	1.1	1.1	-1.2	-1.1	-0.9
Median of all reaction times	0.9	1.2	1.5	1.2	1.1	1.2	-1.2	-1.1	-0.8
Reaction time omissions	1.0	1.4	1.8	1.3	1.3	1.0	-1.3	-1.3	-1.0
Reaction time false alarm rate	2.9	4.0	6.0	-1.9	-2.3	-0.8	2.0	2.1	2.4
Reaction time premature initiation rate	1.5	2.1	3.6	1.5	1.3	1.9	-1.5	-1.5	-0.8
Reaction time premature initiations	0.5	0.9	1.1	1.0	1.0	1.0	-1.0	-1.0	-0.4
Std. dev. reaction times	0.4	0.7	1.0	0.9	1.0	0.6	-0.9	-0.8	-1.0
Reaction time trials completed	0.2	0.3	1.5	-0.3	0.1	-1.2	0.3	0.2	-0.0
Reaction time trials AUC	0.2	0.4	1.7	-0.4	-0.0	-1.3	0.4	0.3	0.1
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.2	0.2	0.2	-0.3	-0.4	-0.1
Run reversals in cocaine runway, males	0.7	0.7	4.2	0.1	0.2	-0.0	-0.3	-0.2	-2.1
Latency to leave start box in cocaine runway	0.5	0.6	0.9	-0.7	-0.9	-0.2	0.8	0.6	0.9
Latency to leave start box in cocaine runway, F	0.1	0.1	0.5	-0.2	-0.4	0.2	0.3	-0.0	0.7
Latency to leave start box in cocaine runway, M	0.3	0.3	0.5	-0.6	-0.7	-0.4	0.6	0.7	-0.0
Std. dev. time between licks in bursts	0.7	1.0	2.8	-0.9	-0.6	-1.7	0.9	0.9	0.5
Total sessions with >9 infusions	0.9	1.1	1.6	1.0	1.1	0.7	-1.0	-1.0	-1.3
Short access day 1 total inactive lever presses	1.3	1.8	2.8	1.3	1.7	0.1	-1.3	-1.4	-1.5
Short access day 10 total inactive lever presses	0.6	1.5	3.6	-1.2	-0.8	-1.9	1.2	0.9	1.0
Short access day 1 total infusions	0.3	0.4	0.7	0.5	0.8	-0.3	-0.5	-0.6	-0.8
Short access day 10 total infusions	1.0	1.3	1.6	1.1	1.2	0.9	-1.1	-1.1	-1.3
Short access total infusions	0.3	0.3	0.6	0.6	0.7	0.2	-0.6	-0.7	-0.6
Short access day 1 locomotion	0.1	0.1	0.3	-0.2	-0.1	-0.5	0.1	0.2	-0.3
Short access day 10 total locomotion	1.0	1.9	3.1	-1.5	-1.3	-1.8	1.4	1.5	0.6
Short access total locomotion	0.9	1.0	1.9	-1.0	-0.8	-1.4	1.1	1.0	0.5
One hour access (0.3 mA shock)	0.1	0.1	0.4	-0.4	-0.2	-0.7	0.3	0.4	-0.0
Compulsive drug intake	1.2	1.5	2.4	1.1	1.2	0.9	-1.2	-1.2	-1.6
One hour access (shock baseline)	0.2	0.4	0.5	-0.6	-0.5	-0.7	0.5	0.7	0.7
Social response proportion	2.2	2.5	3.1	1.6	1.8	1.2	-1.7	-1.6	-1.7
Social responses	0.6	0.7	1.5	0.8	1.1	0.0	-0.8	-0.7	-1.2
Social time	1.0	1.4	3.1	1.0	1.2	0.4	-1.1	-1.0	-1.8
Soleus weight	2.9	8.7	9.8	3.0	3.0	2.6	-3.1	-3.0	-2.9
Bone: stiffness	0.5	0.9	1.4	0.9	1.2	0.1	-0.8	-0.9	-1.1
Tibialis anterior weight	1.5	5.0	7.0	2.2	2.5	1.1	-2.3	-2.2	-2.7
Time to tail flick, vehicle, before self-admin	0.6	0.7	0.9	0.8	0.7	0.9	-0.8	-0.8	-0.8
Time to tail flick, vehicle, after self-admin	0.2	0.3	1.1	0.4	0.1	1.1	-0.2	-0.4	0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.5	0.2	0.3
Time to tail flick, test, after self-admin	0.6	0.6	1.1	-0.8	-1.0	-0.3	0.9	0.8	0.6
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.0	-0.6	-0.7	-0.2	0.7	0.6	1.0
Delta time to tail flick, test, before/after SA	0.4	0.4	0.6	-0.8	-0.8	-0.6	0.6	0.7	0.3
Tibia length	0.0	0.0	0.1	-0.3	-0.2	-0.3	0.1	0.3	0.1
Ambulatory time before self-admin	0.4	0.6	1.0	-0.8	-1.0	-0.4	1.0	0.9	0.3
Ambulatory time after self-admin	0.7	0.8	1.9	1.0	0.7	1.4	-0.6	-0.9	-0.1
Bone: tissue strength	0.3	0.3	0.7	-0.6	-0.8	-0.1	0.6	0.6	0.3
Total heroin consumption	2.5	2.9	3.3	1.8	1.8	1.7	-1.6	-1.8	-1.5
Bone: trabecular number	3.6	5.9	6.4	2.5	2.5	2.3	-2.5	-2.5	-2.2
Bone: trabecular spacing	1.2	1.5	2.6	-1.3	-1.1	-1.6	1.3	1.3	0.7
Bone: trabecular thickness	0.2	0.2	0.5	0.5	0.4	0.7	-0.5	-0.5	0.0
Bone: trabecular tissue density	0.7	1.0	1.4	-1.1	-1.2	-0.7	1.0	1.1	1.1
Water consumed over 24 hours	0.3	0.3	1.1	0.5	0.3	1.0	-0.4	-0.5	0.3
Number of responses in last shaping day	0.6	0.7	2.0	-0.7	-0.8	-0.5	0.6	0.7	1.4