Hub : Genes

Neurod4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr7_7828059_7867710 0.04 0.03 3.7e-04 0.03 0.03 0.04 0.04 3.5e-04 3.8e-04 2.5e-04 2.9e-04
2 PL mRNA stability Neurod4 0.03 0.02 9.9e-04 0.02 0.02 0.02 0.01 7.0e-03 2.9e-03 2.6e-03 7.2e-03
3 Liver gene expression Neurod4 0.03 0.02 1.9e-03 0.02 0.02 0.02 0.02 1.8e-03 2.0e-03 3.0e-03 4.3e-03
4 BLA mRNA stability Neurod4 0.1 0.06 2.2e-06 0.04 0.09 0.08 0.07 2.4e-03 1.6e-05 5.2e-05 9.5e-05
5 pVTA mRNA stability Neurod4 0.05 0.03 1.0e-04 0.04 0.04 0.04 0.04 3.9e-04 3.2e-04 5.1e-04 4.1e-04
6 NAcc intron excision ratio chr7_7828059_7867710 0.05 0.04 1.0e-03 0.02 0.01 0.01 0.02 6.3e-04 1.9e-03 1.3e-02 9.2e-04
7 NAcc mRNA stability Neurod4 0.02 0.02 2.0e-03 0.01 0.01 0.01 0.01 3.7e-03 7.3e-03 2.1e-02 7.9e-03
8 RMTg gene expression Neurod4 0.21 0.12 7.4e-04 0.02 0.09 0.09 0.08 9.2e-02 1.8e-03 2.4e-03 3.6e-03
9 PL alternative TSS XM_063263094.1 0.04 0.03 1.1e-03 0.01 0.02 0.03 0.01 3.1e-02 3.2e-03 8.5e-04 1.3e-02
10 NAcc gene expression Neurod4 0.07 0.04 6.2e-09 0.03 0.06 0.05 0.05 5.2e-05 3.2e-09 2.5e-08 1.5e-08
11 NAcc intron excision ratio chr7_7791333_7867710 0.03 0.02 4.0e-04 0.02 0.03 0.01 0.02 1.3e-03 1.0e-04 2.8e-03 1.3e-04
12 Adipose intron excision ratio chr7_7788644_7791268 0.04 0.03 4.2e-03 0.02 0.01 0.01 0.02 4.2e-03 6.8e-03 1.4e-02 4.6e-03
13 Adipose intron excision ratio chr7_7791333_7827914 0.03 0.02 8.8e-03 0.01 0 0.01 0 4.1e-02 1.2e-01 7.2e-02 1.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.32.45.7-1.2-0.2-1.00.0-0.40.6-0.0-1.92.1-2.12.0-2.42.4
Area under the delay curve0.71.02.11.21.11.2-1.3-1.41.41.30.5-0.40.21.1-0.20.2
BMI with tail5.017.531.75.15.64.9-5.2-4.94.74.83.9-3.63.32.81.2-1.2
BMI without tail0.94.67.52.42.62.7-2.7-2.52.52.42.1-1.91.81.30.7-0.7
Body weight0.94.26.42.42.52.5-2.4-2.12.02.42.3-2.02.00.81.1-1.1
Weight adjusted by age0.00.10.30.20.00.5-0.4-0.40.4-0.20.3-0.50.30.00.3-0.3
Bone surface3.06.013.1-2.3-0.7-2.10.7-0.00.3-0.1-3.33.4-3.52.6-3.63.6
Bone volume2.95.812.7-2.2-0.6-2.00.6-0.10.3-0.2-3.23.4-3.42.6-3.63.6
Breakpoint value in progressive ratio session1.12.04.5-1.3-1.5-1.72.02.1-2.1-1.5-0.90.9-0.5-1.50.2-0.2
Number of licking bursts0.31.02.70.70.90.8-0.5-0.10.00.71.5-1.31.6-0.61.2-1.2
Context. condit. distance diff. score0.30.40.80.90.90.7-0.8-0.70.80.30.5-0.60.40.40.2-0.2
Locomotion velocity, session 11.21.32.9-1.4-0.8-1.40.90.7-0.6-0.4-1.41.7-1.40.6-1.41.4
Locomotion distance, session 11.31.63.3-1.2-0.8-1.10.60.2-0.1-0.6-1.71.8-1.81.1-1.81.8
Locomotion velocity, session 24.04.88.0-2.7-2.0-2.72.21.8-1.8-1.5-2.72.8-2.60.2-2.12.1
Locomotion distance, session 22.94.06.8-2.5-1.9-2.21.81.3-1.2-1.4-2.62.6-2.50.5-2.12.1
Locomotion velocity, session 34.24.88.2-2.5-2.9-2.62.82.8-2.8-2.8-1.71.6-1.2-1.9-0.20.2
Locomotion distance, session 30.10.10.4-0.1-0.4-0.10.20.3-0.3-0.60.0-0.00.1-0.40.2-0.2
Stereotopy head waving bouts, day 33.74.57.1-2.4-2.7-2.52.52.3-2.2-2.6-2.22.0-1.9-1.1-1.01.0
Stereotopy head waving duration, day 34.04.98.2-2.6-2.7-2.62.72.5-2.5-2.9-2.11.9-1.7-1.4-0.80.8
Locomotion velocity, session 70.50.51.0-0.8-0.6-1.00.80.8-0.8-0.3-0.80.9-0.7-0.1-0.60.6
Locomotion distance, session 70.30.40.90.70.40.5-0.3-0.10.00.40.9-0.90.9-0.60.9-0.9
Stereotopy head waving bouts, day 70.70.92.1-0.5-0.5-0.40.0-0.40.4-0.3-1.21.1-1.41.1-1.41.4
Stereotopy head waving duration, day 71.21.43.0-1.0-0.8-1.00.50.1-0.1-0.6-1.61.6-1.71.0-1.71.7
Locomotion velocity, session 81.82.14.5-1.3-1.0-1.40.80.4-0.3-0.7-2.02.0-2.11.0-2.02.0
Locomotion distance, session 80.30.40.7-0.7-0.6-0.60.50.3-0.2-0.6-0.80.8-0.80.2-0.70.7
Degree of sensitization distance0.50.62.30.81.10.7-0.8-0.80.81.50.5-0.50.40.60.0-0.0
Degree of sensitization stereotypy1.01.12.80.80.90.9-1.3-1.61.61.1-0.10.1-0.51.7-1.01.0
Conditioned locomotion1.92.34.01.71.51.9-1.4-1.11.00.72.0-2.01.9-0.31.5-1.5
Cocaine response after cond. corrected3.65.39.12.92.63.0-2.5-2.22.22.32.6-2.72.30.41.4-1.4
Cocaine response after cond. not corrected4.26.010.13.12.63.2-2.7-2.32.32.52.8-2.92.50.31.7-1.7
Cocaine response before conditioning0.40.50.9-0.7-0.9-1.00.80.7-0.7-0.5-0.80.8-0.7-0.2-0.20.2
Saline control response0.30.50.90.80.50.7-0.5-0.30.20.10.9-0.91.0-0.30.9-0.9
Bone: connectivity density0.81.22.9-0.60.1-0.3-0.3-0.70.90.1-1.21.3-1.51.7-1.71.7
Bone: cortical apparent density0.71.02.11.11.01.3-1.4-1.51.50.90.7-0.70.51.10.0-0.0
Bone: cortical area0.71.13.10.10.7-0.1-0.6-0.91.00.6-0.80.9-1.11.8-1.61.6
Bone: cortical porosity0.30.30.7-0.5-0.0-0.60.40.2-0.20.4-0.80.8-0.80.4-0.70.7
Bone: cortical porosity0.50.61.3-0.40.2-0.60.1-0.10.20.7-1.01.0-1.11.0-1.11.1
Bone: cortical thickness0.71.12.71.11.20.8-1.3-1.51.51.10.10.0-0.21.6-0.90.9
Bone: cortical thickness0.20.30.80.20.10.20.10.4-0.5-0.60.7-0.60.9-0.70.7-0.7
Bone: cortical tissue density0.50.71.60.90.81.1-1.2-1.21.30.70.6-0.60.40.9-0.00.0
Condit. Reinf. active minus inactive responses2.73.15.0-2.1-2.0-2.22.22.2-2.2-2.2-1.51.5-1.1-1.2-0.40.4
Condit. Reinf. active-inactive response ratio1.31.33.1-1.1-1.2-1.21.51.7-1.8-1.6-0.30.4-0.0-1.50.5-0.5
Condit. Reinf. active responses2.93.86.0-2.3-2.2-2.42.32.0-2.0-1.9-2.22.1-1.9-0.6-1.31.3
Condit. Reinf. inactive responses1.41.83.4-1.4-1.2-1.51.10.7-0.6-0.5-1.81.7-1.80.5-1.61.6
Incentive salience index mean1.82.33.9-1.8-1.5-2.01.71.6-1.5-1.4-1.71.7-1.6-0.3-1.11.1
Condit. Reinf. lever presses1.01.43.5-0.8-0.2-0.90.3-0.10.20.4-1.61.6-1.71.3-1.91.9
Condit. Reinf. active minus inactive responses1.52.35.2-1.4-1.8-1.31.82.0-2.0-2.3-0.40.2-0.0-2.00.8-0.8
Condit. Reinf. active-inactive response ratio0.81.22.80.3-0.30.30.30.6-0.8-1.41.0-1.21.2-1.61.7-1.7
Condit. Reinf. active responses1.72.54.2-2.0-2.0-1.92.02.0-2.0-2.1-1.11.1-0.8-1.4-0.00.0
Condit. Reinf. inactive responses1.01.53.0-1.7-1.3-1.61.41.2-1.2-0.7-1.41.4-1.2-0.3-0.80.8
Condit. Reinf. lever presses1.31.93.5-1.6-1.7-1.41.81.9-1.9-1.7-0.70.5-0.4-1.70.4-0.4
Condit. Reinf. lever reinforcers received1.31.93.4-1.7-1.7-1.51.81.8-1.9-1.8-0.70.6-0.4-1.50.3-0.3
Conditioned reinforcement - actives0.31.12.2-1.3-1.2-1.11.31.4-1.5-1.4-0.30.3-0.0-1.30.1-0.2
Conditioned reinforcement - inactives0.20.51.00.1-0.20.6-0.2-0.00.0-0.50.9-1.01.0-0.81.0-1.0
Conditioned locomotion4.97.211.7-3.4-3.2-3.33.43.4-3.2-3.1-2.22.3-1.7-2.0-0.90.9
Patch foraging indifference point 0 sec0.20.51.90.41.40.5-0.8-0.60.51.30.5-0.20.40.8-0.20.2
Patch foraging indifference point AUC0.30.71.9-0.6-0.8-1.21.31.3-1.4-0.6-0.60.5-0.4-0.90.0-0.0
Delay disc. indifference point, 0s delay4.34.810.11.92.42.0-2.8-3.13.22.60.3-0.1-0.43.1-1.51.5
Delay disc. indifference point, 16s delay0.10.10.20.0-0.00.1-0.3-0.40.40.1-0.20.3-0.30.4-0.30.3
Delay disc. indifference point, 2s delay3.13.47.71.91.82.3-2.4-2.72.82.10.6-0.80.12.3-0.80.8
Delay disc. indifference point, 24s delay0.20.41.10.91.10.4-0.6-0.60.51.00.4-0.30.30.50.0-0.0
Delay disc. indifference point, 4s delay0.80.82.00.50.40.6-0.9-1.21.30.9-0.40.2-0.71.4-1.11.1
Delay disc. indifference point, 8s delay0.50.81.41.20.91.0-1.0-0.90.80.91.0-0.80.90.10.8-0.8
Indifference point function ln k0.10.20.40.30.10.6-0.5-0.50.5-0.20.5-0.50.40.10.2-0.2
Indifference point function log k0.10.20.40.30.10.6-0.5-0.50.5-0.20.5-0.50.40.10.2-0.2
Patch foraging total patch changes 0 sec0.10.41.60.31.30.4-0.7-0.60.41.20.5-0.20.40.7-0.20.2
Patch foraging total patch changes 12 sec0.60.71.91.01.40.8-0.7-0.50.41.21.0-0.91.00.10.7-0.7
Patch foraging total patch changes 18 sec0.20.41.1-0.9-0.2-1.10.80.9-1.0-0.2-0.60.8-0.4-0.3-0.20.2
Patch foraging total patch changes 24 sec0.00.10.3-0.50.1-0.60.20.2-0.30.2-0.30.5-0.30.3-0.30.3
Patch foraging total patch changes 6 sec0.10.20.6-0.30.5-0.50.30.5-0.60.8-0.10.30.00.1-0.40.4
Patch foraging time to switch 0 sec0.31.23.30.40.90.9-1.4-1.71.71.1-0.10.2-0.51.8-0.90.9
Patch foraging water rate 0 sec0.20.82.00.50.30.40.10.5-0.6-0.61.2-1.11.4-1.21.2-1.2
Patch foraging water rate 12 sec0.51.93.71.51.01.8-1.3-1.01.00.51.9-1.81.9-0.41.3-1.3
Patch foraging water rate 18 sec1.22.75.90.6-0.30.80.20.8-0.9-1.42.0-1.92.3-2.42.4-2.4
Patch foraging water rate 24 sec3.04.310.21.81.11.8-0.8-0.1-0.1-0.43.0-2.93.2-2.02.9-2.9
Patch foraging water rate 6 sec1.11.64.20.1-1.00.10.61.0-1.0-1.81.1-1.11.3-2.11.7-1.7
Seeking ratio, delayed vs. immediate footshock2.53.66.6-2.2-2.0-2.62.42.2-2.2-1.7-1.92.0-1.6-0.9-0.90.9
Distance traveled before self-admin0.10.21.1-0.7-1.0-0.10.0-0.20.2-1.1-0.40.2-0.50.1-0.20.2
Distance traveled after self-admin0.00.10.3-0.6-0.3-0.50.30.4-0.4-0.1-0.10.2-0.1-0.2-0.00.0
Extensor digitorum longus weight3.514.221.54.64.44.6-4.4-3.93.74.44.1-3.83.61.42.1-2.1
Bone: elastic displacement0.20.21.3-0.6-0.6-0.50.50.5-0.5-1.1-0.30.3-0.2-0.2-0.20.2
Bone: elastic work0.20.20.80.20.50.2-0.5-0.60.60.2-0.10.2-0.20.9-0.70.7
Bone: endosteal estimation0.20.51.30.00.80.2-0.7-0.80.81.1-0.20.3-0.41.1-0.80.8
Bone: endosteal perimeter0.51.22.3-1.1-0.7-1.20.80.5-0.4-0.4-1.51.5-1.50.5-1.41.4
Epididymis fat weight0.10.71.60.90.20.6-0.10.1-0.2-0.11.1-1.31.3-1.11.2-1.2
Delta time in closed arm before/after self-admin2.42.34.91.20.61.4-0.7-0.20.10.22.1-2.12.2-1.32.2-2.2
Delta time in open arm before/after self-admin0.50.61.31.11.10.8-1.0-0.90.81.10.8-0.50.70.60.2-0.2
Diff in mean of infusions in LGA sessions0.61.12.7-1.0-1.7-1.11.41.3-1.3-1.4-0.80.6-0.7-1.0-0.00.0
Delay discount exponential model param0.60.81.6-1.1-1.0-1.01.21.3-1.3-1.2-0.50.4-0.2-0.90.1-0.1
Extinction: sum of active levers before priming0.60.82.2-0.5-1.1-0.71.01.1-1.2-1.5-0.0-0.10.2-1.40.8-0.8
Active lever presses in extinction session 61.21.22.7-1.1-0.8-1.71.51.5-1.6-0.7-1.01.2-0.8-0.7-0.40.4
Bone: final force0.91.54.70.61.40.5-1.3-1.51.51.3-0.30.6-0.62.2-1.41.4
Bone: final moment0.91.44.20.61.40.4-1.2-1.41.41.2-0.30.6-0.62.1-1.41.4
Food consumed during 24 hour testing period0.20.40.70.80.70.8-0.8-0.80.80.80.5-0.50.40.5-0.10.1
Glucose1.52.44.32.02.11.9-2.0-1.91.91.41.4-1.31.21.10.4-0.4
Heart weight0.50.71.6-0.7-1.0-0.71.01.2-1.3-1.00.00.10.3-1.30.5-0.5
Delay discount hyperbolic model param1.21.53.1-1.4-1.3-1.41.61.8-1.8-1.6-0.50.5-0.2-1.40.4-0.4
Intermittent access intake day 1-15 change0.73.88.0-2.2-2.3-2.02.52.7-2.8-2.4-0.60.5-0.1-2.40.9-0.9
Intermittent access intake escalation0.63.47.0-2.0-2.2-1.82.32.6-2.6-2.3-0.50.40.0-2.31.0-0.9
Intermittent access intake escalation 21.83.05.9-2.1-2.2-1.92.22.4-2.4-2.0-0.70.7-0.3-2.00.6-0.6
Intermitt. access day 1 inactive lever presses0.10.92.3-0.0-0.7-0.20.70.9-1.0-1.30.4-0.70.7-1.51.5-1.5
Intermitt. access day 15 inactive lever presses0.10.31.1-0.4-0.8-0.40.60.6-0.5-1.1-0.30.1-0.2-0.60.5-0.5
Intermitt. access escalation Index0.20.82.20.30.70.5-0.9-1.21.30.9-0.40.2-0.71.5-0.91.0
Intermittent access day 1 total infusions0.00.10.3-0.2-0.0-0.10.30.4-0.4-0.20.3-0.10.4-0.50.2-0.2
Intermittent access day 15 total infusions0.71.83.8-1.7-1.4-1.61.82.0-1.9-1.5-0.60.7-0.2-1.50.2-0.2
Intermittent access terminal intake (last 3 days)0.91.63.4-1.8-1.5-1.61.61.6-1.5-1.3-0.91.0-0.6-0.9-0.30.3
Intermittent access total infusions0.50.61.2-1.1-0.8-0.91.01.1-1.0-0.8-0.30.4-0.1-0.80.0-0.0
Intermittent access day 1 locomotion0.40.82.6-0.2-0.2-0.61.01.4-1.5-0.60.4-0.30.8-1.60.8-0.8
Intermittent access day 15 total locomotion0.82.96.3-1.7-1.9-1.72.22.5-2.5-2.1-0.50.50.0-2.20.7-0.7
Intermittent access total locomotion1.21.43.3-1.1-1.1-1.31.61.8-1.8-1.4-0.30.30.1-1.60.4-0.4
Intermittent access standard deviation1.05.29.2-3.0-2.6-3.02.92.9-2.8-2.1-2.02.1-1.5-1.5-0.50.5
Left kidney weight0.00.10.30.10.00.2-0.10.1-0.1-0.40.5-0.50.5-0.40.4-0.4
Right kidney weight0.11.02.6-0.6-0.9-1.11.31.5-1.6-1.2-0.20.20.1-1.40.4-0.4
Cocaine induced anxiety0.82.23.7-1.8-1.4-1.81.41.1-1.0-1.0-1.91.9-1.80.2-1.51.5
Post-drug Anxiety2.12.44.2-1.7-1.1-1.81.20.9-0.9-0.5-2.02.1-2.00.7-1.91.9
Baseline Anxiety0.00.00.2-0.1-0.0-0.10.10.1-0.50.00.00.00.0-0.10.0-0.0
Tail length1.78.916.3-3.7-4.0-3.33.93.9-3.8-3.4-2.22.1-1.6-2.8-0.10.1
Length with tail1.14.99.3-2.5-2.9-2.32.93.0-3.0-2.7-1.11.1-0.6-2.60.5-0.5
Length without tail0.10.30.60.60.50.3-0.20.0-0.10.20.7-0.60.8-0.40.7-0.7
Times rat made contact with spout0.50.61.40.70.70.7-0.5-0.30.20.81.1-1.01.2-0.31.0-1.0
Lifetime Intake0.20.20.6-0.7-0.3-0.70.70.8-0.7-0.4-0.20.3-0.0-0.5-0.00.0
Liver weight, left0.61.01.61.21.11.3-1.2-1.11.21.21.0-0.90.80.60.2-0.2
Liver weight, right0.30.51.11.10.51.0-0.8-0.70.70.10.8-1.00.70.00.5-0.5
Locomotor activity2.54.06.8-2.3-2.2-2.62.32.0-1.9-1.7-2.42.3-2.1-0.5-1.11.1
Locomotor testing distance1.02.44.3-1.9-1.8-2.11.81.6-1.5-1.0-1.91.8-1.7-0.3-0.80.8
Locomotor testing rearing0.00.10.30.1-0.1-0.10.10.2-0.2-0.10.2-0.30.2-0.30.5-0.5
Locomotion in novel chamber0.70.92.2-1.2-0.8-1.31.31.4-1.5-0.5-0.60.8-0.3-0.8-0.00.0
Locomotion in novel chamber post-restriction0.61.74.0-1.4-1.8-1.31.51.3-1.3-2.0-1.31.0-1.1-0.8-0.40.4
Fecal boli incidents, locomotor time 10.71.93.51.61.41.9-1.5-1.31.30.91.6-1.81.50.21.0-1.0
Change in fecal boli incidents, locomotor task1.21.32.7-1.1-0.7-1.20.70.4-0.4-0.5-1.61.7-1.60.7-1.51.5
Time >=10cm from walls, locomotor time 10.50.61.70.20.70.0-0.5-0.70.80.8-0.60.7-0.81.3-1.21.2
Bouts of movement, locomotor time 10.20.30.7-0.5-0.9-0.50.60.6-0.5-0.8-0.30.3-0.2-0.60.2-0.2
Total resting periods, locomotor time 10.40.51.4-0.9-1.2-0.60.70.7-0.5-1.1-0.60.5-0.5-0.5-0.00.0
Rest time, locomotor task time 10.30.41.0-1.0-0.9-0.50.50.3-0.1-0.6-0.80.8-0.80.2-0.70.7
Distance moved, locomotor task time 10.30.92.40.50.90.2-0.8-1.00.91.3-0.50.5-0.71.5-1.21.2
Vertical activity count, locomotor time 10.00.20.80.90.90.3-0.4-0.30.10.70.5-0.40.50.10.3-0.3
Time >=10cm from walls, locomotor time 20.31.01.61.21.11.3-1.0-0.90.80.91.2-1.11.10.10.7-0.7
Bouts of movement, locomotor time 20.20.71.9-0.20.1-1.10.60.5-0.3-0.0-1.21.4-1.20.4-1.11.1
Total resting periods, locomotor time 20.20.92.3-0.20.1-1.10.60.4-0.20.1-1.31.5-1.30.6-1.31.3
Rest time, locomotor task time 20.40.71.6-0.7-0.3-1.10.80.7-0.60.0-1.11.3-1.00.2-1.01.0
Distance moved, locomotor task time 20.50.61.30.70.21.1-0.9-0.80.70.11.0-1.10.9-0.10.8-0.8
Vertical activity count, locomotor time 20.61.42.51.31.01.2-1.0-0.70.60.61.6-1.51.6-0.41.4-1.4
Light reinforcement 11.67.212.3-3.4-3.5-3.33.33.1-3.0-3.0-2.42.4-2.0-1.7-0.80.8
Light reinforcement 20.71.62.6-1.4-1.6-1.51.61.5-1.5-1.5-1.11.1-0.9-0.9-0.30.3
Bone: marrow area0.20.51.30.10.80.2-0.7-0.80.81.1-0.20.3-0.31.1-0.70.7
Bone: maximum diameter1.12.24.0-1.6-1.1-1.81.30.9-0.9-1.0-2.02.0-1.90.5-1.71.7
Bone: maximum force0.81.64.10.91.70.7-1.5-1.61.61.40.00.2-0.32.0-1.21.2
Bone: maximum moment0.81.53.70.91.70.7-1.4-1.51.51.40.10.2-0.21.9-1.21.2
Mean time between licks in bursts0.63.46.4-2.3-2.1-2.22.42.5-2.5-2.3-1.21.2-0.7-1.7-0.10.1
Mean num. licks in bursts0.00.10.3-0.1-0.3-0.20.1-0.10.1-0.2-0.50.4-0.60.3-0.30.3
Cd content in liver0.20.20.6-0.6-0.8-0.50.60.5-0.5-0.5-0.50.5-0.5-0.2-0.20.2
Co content in liver1.21.52.6-1.4-1.6-1.21.51.6-1.6-1.5-0.60.5-0.3-1.50.4-0.4
Cu content in liver0.50.71.4-0.40.1-1.00.50.3-0.30.3-1.11.2-1.10.7-1.21.2
Fe content in liver0.10.10.30.0-0.2-0.10.30.4-0.5-0.40.3-0.20.4-0.60.5-0.5
K content in liver0.70.71.4-0.9-0.7-0.70.40.1-0.0-0.7-1.11.1-1.20.5-1.01.0
Mg content in liver0.60.71.2-1.1-0.8-0.90.80.6-0.6-0.6-1.11.0-1.10.1-0.80.8
Mn content in liver3.43.87.5-2.0-1.3-2.11.51.0-0.8-0.8-2.72.7-2.71.0-2.52.5
Na content in liver0.50.51.40.50.70.5-0.9-1.11.10.5-0.10.1-0.31.2-0.70.7
Rb content in liver0.80.92.2-0.7-0.2-0.70.2-0.10.2-0.0-1.21.3-1.41.1-1.51.5
Se content in liver0.10.20.4-0.5-0.3-0.60.50.5-0.5-0.6-0.20.3-0.2-0.3-0.00.0
Sr content in liver0.20.20.50.30.10.3-0.00.1-0.10.30.5-0.60.5-0.50.7-0.7
Zn content in liver2.73.17.8-1.4-1.9-1.32.12.5-2.5-1.90.1-0.20.6-2.81.6-1.6
Bone: minimum diameter0.30.51.5-0.30.1-0.4-0.1-0.30.30.1-0.80.9-0.91.0-1.21.2
Time in familiar zone, hab. session 11.41.53.5-1.4-1.9-1.21.61.6-1.5-1.5-0.70.5-0.5-1.40.3-0.3
Time in novel zone, hab. session 10.91.03.00.51.20.5-1.1-1.21.21.0-0.20.4-0.41.7-1.11.1
Total zone transitions, hab. session 11.52.13.7-1.7-1.2-1.61.10.8-0.8-1.1-1.81.9-1.80.6-1.71.7
Total locomotion distance, hab. session 12.94.18.0-2.1-1.6-2.11.50.9-0.8-1.2-2.82.8-2.81.0-2.52.5
Locomotion velocity, hab. session 12.63.76.4-2.1-1.8-2.21.71.2-1.1-1.3-2.52.5-2.50.5-2.12.1
Time in familiar zone, hab. session 23.84.38.1-2.2-2.6-2.12.72.9-2.9-2.6-0.90.7-0.4-2.60.8-0.8
Time in novel zone, hab. session 23.03.36.31.82.31.6-2.3-2.52.42.30.5-0.30.12.5-1.01.0
Total zone transitions, hab. session 21.11.43.7-0.60.1-0.4-0.3-0.70.80.6-1.21.4-1.51.8-1.91.9
Total locomotion distance, hab. session 21.41.93.3-1.7-1.3-1.61.21.0-0.9-0.9-1.71.8-1.60.3-1.41.4
Locomotion velocity, hab. session 21.72.34.3-1.9-1.3-1.71.20.9-0.8-0.9-2.02.1-1.90.6-1.81.8
Novel to familiar place preference ratio2.22.96.31.32.01.3-2.0-2.22.32.50.10.1-0.42.5-1.31.3
Novelty place preference1.41.84.40.81.50.9-1.5-1.71.81.9-0.10.3-0.52.1-1.31.3
Time in novel zone, NPP test1.62.04.51.01.71.0-1.6-1.81.92.00.00.1-0.32.1-1.21.2
Total zone transitions, NPP test0.30.41.1-0.30.2-0.3-0.1-0.20.30.4-0.60.8-0.71.0-1.01.0
Total locomotion distance, NPP test0.50.71.9-0.5-0.1-0.50.0-0.20.30.3-1.01.1-1.21.1-1.41.4
Locomotion velocity, NPP test0.60.81.8-0.8-0.4-0.80.30.1-0.0-0.0-1.21.2-1.30.9-1.31.3
Intraocular pressure0.61.02.70.1-0.40.50.10.4-0.4-0.71.2-1.11.3-1.41.6-1.6
Delta distance traveled before/after self-admin0.10.10.4-0.10.2-0.40.40.6-0.60.60.20.00.3-0.30.2-0.2
Delta ambulatory time before/after self-admin0.10.20.6-0.30.2-0.70.40.5-0.50.8-0.30.6-0.20.1-0.40.4
Parametrial fat weight0.00.10.3-0.50.0-0.1-0.1-0.10.10.3-0.10.3-0.10.4-0.30.3
Pavlov. Cond. lever latency0.81.02.50.50.10.7-0.10.2-0.3-0.41.3-1.31.4-1.21.6-1.6
Pavlov. Cond. magazine entry latency1.62.03.5-1.8-1.7-1.81.91.9-1.8-1.5-1.11.1-0.8-1.2-0.20.2
Pavlov. Cond. change in total contacts0.00.00.1-0.3-0.1-0.30.20.2-0.2-0.1-0.20.3-0.10.0-0.20.2
Pavlov. Cond. index score0.50.61.1-0.9-0.6-0.90.70.5-0.5-0.3-1.11.0-1.00.2-0.90.9
Pavlov. Cond. latency score0.71.01.9-0.9-0.6-1.00.70.4-0.4-0.3-1.41.3-1.40.5-1.31.3
Pavlov. Cond. lever contacts0.70.82.0-0.40.1-0.60.1-0.20.30.6-1.11.1-1.21.1-1.41.4
Pavlov. Cond. magazine entry number0.30.40.80.90.80.8-0.9-0.90.90.50.5-0.40.30.7-0.00.0
Pavlov. Cond. intertrial magazine entries0.40.51.10.2-0.30.10.30.5-0.6-0.60.6-0.70.8-1.01.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.50.71.1-1.0-0.7-1.00.80.7-0.6-0.4-1.11.0-1.00.1-0.80.8
Pavlov. Cond. response bias0.40.50.9-0.8-0.8-0.90.90.9-0.9-0.4-0.60.6-0.5-0.5-0.20.2
Pavlov. Cond. lever latency0.71.01.71.31.21.2-1.3-1.21.20.61.0-0.90.80.70.3-0.3
Pavlov. Cond. magazine entry latency0.50.71.7-1.1-1.3-0.90.90.7-0.7-0.3-1.00.8-1.0-0.3-0.40.4
Pavlov. Cond. change in total contacts0.30.81.5-1.1-1.2-1.11.21.2-1.2-0.8-0.60.5-0.4-1.00.1-0.1
Pavlov. Cond. index score0.50.81.9-1.2-1.4-1.11.21.1-1.1-0.7-0.90.7-0.7-0.7-0.10.1
Pavlov. Cond. latency score0.60.91.8-1.3-1.3-1.21.21.0-1.0-0.6-1.10.9-0.9-0.5-0.40.4
Pavlov. Cond. lever contacts0.50.71.3-1.1-1.1-1.01.11.1-1.1-0.6-0.70.5-0.5-0.80.0-0.0
Pavlov. Cond. magazine entry number0.91.22.41.51.51.3-1.2-1.01.00.61.3-1.11.20.40.5-0.5
Pavlov. Cond. intertrial magazine entries0.40.91.51.21.11.1-0.9-0.70.60.41.2-1.11.2-0.00.9-0.9
Pavlov. Cond. lever-magazine prob. diff.0.71.02.1-1.3-1.4-1.21.21.1-1.1-0.6-1.10.9-1.0-0.6-0.30.3
Pavlov. Cond. response bias1.21.73.1-1.6-1.8-1.51.71.7-1.7-1.2-0.90.8-0.6-1.30.1-0.1
Time in closed arm before self-admin0.40.61.70.40.70.2-0.7-0.90.90.7-0.50.4-0.71.3-1.11.1
Time in closed arm after self-admin0.10.20.40.0-0.0-0.30.40.6-0.60.00.2-0.20.3-0.60.4-0.4
Time in open arm before self-admin0.20.30.6-0.7-0.8-0.40.60.7-0.6-0.6-0.30.2-0.1-0.50.1-0.1
Time in open arm after self-admin1.01.11.81.11.21.3-1.3-1.11.01.21.3-1.01.10.40.7-0.7
Bone: periosteal estimation0.51.33.4-0.10.9-0.1-0.7-0.91.01.1-0.81.0-1.11.9-1.71.7
Bone: periosteal perimeter0.61.22.9-0.7-0.2-1.00.40.1-0.0-0.2-1.51.6-1.61.1-1.71.7
Bone: post-yield work0.40.71.31.01.10.9-1.1-1.11.01.00.6-0.60.40.7-0.10.1
Progressive ratio test 1 active lever presses0.00.10.30.10.20.10.10.2-0.2-0.10.4-0.30.5-0.40.3-0.3
Progressive ratio test 1 breakpoint0.10.10.30.20.30.10.00.2-0.2-0.10.5-0.40.5-0.40.3-0.3
Progressive ratio test 1 inactive lever presses0.10.20.8-0.5-0.6-0.40.60.6-0.6-0.9-0.30.1-0.2-0.6-0.00.0
Progressive ratio test 2 active lever presses0.30.41.2-0.7-0.8-0.40.70.8-0.8-1.10.00.00.2-0.90.2-0.2
Progressive ratio test 2 breakpoint0.40.51.3-0.8-0.8-0.50.80.9-0.9-1.1-0.10.10.1-0.90.1-0.1
Progressive ratio test 2 inactive lever presses0.10.20.5-0.7-0.4-0.60.50.5-0.4-0.5-0.50.5-0.4-0.1-0.40.4
Incentive Sensitization - Responses0.10.21.0-0.4-0.60.00.30.4-0.3-1.00.2-0.30.3-0.70.3-0.3
Incentive Sensitization - Breakpoint0.10.31.1-0.6-0.8-0.20.40.5-0.4-1.10.0-0.10.1-0.70.1-0.1
Sum of active levers in priming session hrs 5-60.00.00.20.40.10.2-0.1-0.10.1-0.10.2-0.20.2-0.20.2-0.2
Progressive ratio0.20.71.21.10.90.9-0.7-0.50.40.61.0-1.01.0-0.20.8-0.8
Food seeking constrained by brief footshock0.20.21.0-0.8-1.0-0.20.40.4-0.3-0.8-0.30.1-0.2-0.40.1-0.1
Seeking ratio, punishment vs. effort0.20.51.5-1.1-1.2-0.60.60.4-0.3-1.0-0.70.5-0.7-0.2-0.40.4
Retroperitoneal fat weight1.04.47.52.52.42.3-2.0-1.51.31.82.7-2.52.7-0.11.9-1.9
Reaction time number correct0.41.42.71.31.21.3-0.9-0.60.60.41.6-1.61.6-0.41.3-1.3
Reaction time mean minus median0.10.81.5-1.1-1.2-1.21.11.0-1.0-0.5-1.00.9-0.9-0.4-0.40.4
Reaction time mean minus median AUC0.21.53.4-0.9-0.7-0.90.3-0.10.20.6-1.71.5-1.91.2-1.81.8
Reaction time num false alarms0.10.21.10.20.60.4-0.4-0.20.11.10.6-0.40.6-0.00.5-0.5
Reaction time num false alarms AUC0.20.41.30.50.60.6-0.4-0.20.01.10.8-0.70.9-0.20.8-0.8
Reaction time trials correct on left0.41.42.71.31.21.3-0.9-0.60.60.41.6-1.61.6-0.41.3-1.3
Reaction time trials on left0.41.32.41.31.21.3-1.0-0.70.60.51.6-1.51.6-0.41.2-1.2
Reaction time mean0.40.82.0-0.4-0.2-0.50.1-0.30.40.4-1.21.1-1.41.0-1.31.3
Reaction time mean AUC0.30.71.6-0.30.0-0.4-0.0-0.40.50.6-1.11.0-1.21.1-1.31.3
Median of all reaction times0.50.81.90.10.3-0.0-0.4-0.80.90.7-0.90.8-1.21.4-1.31.3
Reaction time omissions0.20.40.8-0.5-0.3-0.60.30.2-0.20.6-0.80.8-0.90.5-0.90.9
Reaction time false alarm rate0.10.11.3-0.00.2-0.0-0.1-0.10.01.1-0.10.2-0.10.3-0.10.1
Reaction time premature initiation rate0.60.92.4-0.5-1.2-0.61.11.2-1.3-1.30.1-0.20.4-1.50.8-0.8
Reaction time premature initiations0.41.33.60.2-0.60.10.61.0-1.1-1.11.0-1.01.3-1.91.6-1.6
Std. dev. reaction times0.20.71.5-0.7-0.7-1.00.70.4-0.40.3-1.21.0-1.20.3-1.01.0
Reaction time trials completed0.41.32.41.31.21.3-1.0-0.70.60.51.6-1.51.6-0.41.2-1.2
Reaction time trials AUC0.51.63.21.41.21.4-1.0-0.60.50.41.8-1.71.8-0.51.4-1.4
Run reversals in cocaine runway, females1.71.93.6-1.9-1.6-1.51.31.0-0.9-1.1-1.71.6-1.60.0-1.21.2
Run reversals in cocaine runway, males1.92.13.5-1.9-1.7-1.61.51.2-1.2-1.3-1.71.8-1.6-0.1-1.21.2
Latency to leave start box in cocaine runway0.91.33.1-1.1-0.2-1.40.70.5-0.40.5-1.41.8-1.40.8-1.51.5
Latency to leave start box in cocaine runway, F1.41.74.1-0.90.1-0.8-0.0-0.40.41.0-1.51.7-1.71.8-2.02.0
Latency to leave start box in cocaine runway, M0.80.82.0-0.7-0.7-1.11.21.4-1.4-0.7-0.10.40.2-1.20.5-0.5
Std. dev. time between licks in bursts0.91.72.7-1.6-1.0-1.41.10.9-0.8-0.8-1.61.6-1.60.3-1.61.6
Total sessions with >9 infusions0.20.20.4-0.6-0.4-0.50.60.6-0.6-0.5-0.20.3-0.1-0.5-0.20.2
Short access day 1 total inactive lever presses0.10.30.9-0.0-0.5-0.20.60.6-0.6-0.80.1-0.20.3-1.00.6-0.6
Short access day 10 total inactive lever presses0.10.92.40.4-0.40.60.10.3-0.3-0.81.0-1.11.2-1.31.5-1.5
Short access day 1 total infusions0.00.10.2-0.3-0.2-0.40.40.4-0.4-0.3-0.20.2-0.1-0.3-0.10.1
Short access day 10 total infusions0.00.00.1-0.3-0.2-0.10.20.2-0.2-0.20.0-0.10.1-0.20.1-0.1
Short access total infusions0.10.10.3-0.5-0.1-0.50.50.6-0.5-0.2-0.20.2-0.1-0.3-0.10.1
Short access day 1 locomotion0.50.82.2-0.8-1.1-0.81.21.2-1.2-1.5-0.40.2-0.2-1.20.2-0.2
Short access day 10 total locomotion1.25.09.6-2.2-2.7-2.12.83.1-3.1-3.1-0.60.5-0.0-3.01.1-1.1
Short access total locomotion1.01.53.1-1.1-1.3-1.31.61.8-1.7-1.7-0.50.4-0.2-1.60.4-0.4
One hour access (0.3 mA shock)0.20.30.6-0.1-0.10.6-0.3-0.10.1-0.30.7-0.70.8-0.50.7-0.7
Compulsive drug intake0.30.41.20.50.50.7-0.8-1.01.10.5-0.0-0.2-0.20.9-0.40.4
One hour access (shock baseline)0.20.41.1-0.9-0.9-0.40.60.7-0.7-1.00.0-0.10.2-0.80.4-0.4
Social response proportion0.91.13.3-1.8-1.3-1.01.00.9-0.7-1.4-1.01.2-0.9-0.2-0.60.6
Social responses7.49.719.7-4.4-4.1-3.53.53.2-3.0-3.6-3.13.2-2.7-1.3-1.41.4
Social time0.61.01.51.01.11.2-1.1-0.90.91.01.2-1.01.10.20.8-0.8
Soleus weight5.616.526.94.75.24.9-5.2-5.15.05.13.3-3.02.53.20.7-0.7
Bone: stiffness1.52.75.21.52.31.5-2.1-2.22.22.20.6-0.40.22.2-0.80.8
Tibialis anterior weight0.62.24.41.72.01.6-1.8-1.71.72.11.3-1.01.01.20.3-0.3
Time to tail flick, vehicle, before self-admin0.40.51.2-0.5-0.6-0.70.60.3-0.3-0.4-1.10.9-1.10.3-0.90.9
Time to tail flick, vehicle, after self-admin0.30.71.90.2-0.4-0.10.60.8-0.8-0.50.6-0.50.8-1.41.2-1.2
Time to tail flick, test, before self-admin0.91.12.4-0.8-0.6-1.00.60.3-0.2-0.5-1.51.3-1.60.7-1.41.4
Time to tail flick, test, after self-admin0.20.20.5-0.4-0.2-0.30.30.2-0.10.2-0.60.7-0.60.3-0.60.6
Delta time to tail flick, vehicle, before/after SA1.31.43.11.11.01.0-0.6-0.20.20.81.7-1.41.8-0.81.6-1.6
Delta time to tail flick, test, before/after SA0.60.71.80.50.00.6-0.20.1-0.2-0.01.1-1.01.2-1.01.3-1.3
Tibia length0.61.64.2-1.2-1.7-1.31.61.6-1.6-2.0-0.70.6-0.4-1.40.2-0.2
Ambulatory time before self-admin0.00.10.4-0.3-0.50.1-0.1-0.20.2-0.6-0.0-0.1-0.1-0.00.1-0.1
Ambulatory time after self-admin0.00.00.1-0.3-0.1-0.30.10.1-0.20.1-0.10.2-0.10.0-0.10.1
Bone: tissue strength1.51.63.11.21.71.2-1.7-1.71.61.80.8-0.60.51.5-0.30.3
Total heroin consumption1.31.52.4-1.2-1.4-1.51.51.3-1.2-1.3-1.41.3-1.3-0.5-0.70.7
Bone: trabecular number1.12.03.8-1.8-1.1-1.51.00.7-0.6-0.9-1.81.9-1.80.7-1.71.7
Bone: trabecular spacing2.02.96.31.70.61.6-0.8-0.30.2-0.12.3-2.42.4-1.52.5-2.5
Bone: trabecular thickness3.34.611.3-1.6-0.3-1.50.2-0.40.60.4-2.72.9-3.02.7-3.43.4
Bone: trabecular tissue density1.93.35.32.32.02.2-2.0-1.81.71.92.1-1.91.90.51.2-1.2
Water consumed over 24 hours0.40.72.60.50.80.5-0.9-1.01.11.6-0.10.2-0.31.2-0.70.7
Number of responses in last shaping day1.31.75.7-1.3-1.9-1.01.51.4-1.4-2.4-0.60.3-0.3-1.50.5-0.5